                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  Pharmacologically Induced Transgene Ablation System

<130>  UPN-W5486C1PCT

<150>  US 13/247,306
<151>  2011-09-28

<160>  818   

<170>  PatentIn version 3.5

<210>  1
<211>  579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified Gin enzyme


<220>
<221>  CDS
<222>  (1)..(579)

<400>  1
atg ctg atc ggc tac gtg cgg gtg tcc acc aac gac cag aac acc gac         48
Met Leu Ile Gly Tyr Val Arg Val Ser Thr Asn Asp Gln Asn Thr Asp           
1               5                   10                  15                

ctg cag cgg aac gcc ctg gtc tgc gcc ggc tgc gag cag atc ttc gag         96
Leu Gln Arg Asn Ala Leu Val Cys Ala Gly Cys Glu Gln Ile Phe Glu           
            20                  25                  30                    

gac aag ctg agc ggc acc cgg acc gac aga ccc gga ctg aag cgg gcc        144
Asp Lys Leu Ser Gly Thr Arg Thr Asp Arg Pro Gly Leu Lys Arg Ala           
        35                  40                  45                        

ctg aag cgg ctg cag aaa ggc gac acc ctg gtg gtc tgg aag ctg gac        192
Leu Lys Arg Leu Gln Lys Gly Asp Thr Leu Val Val Trp Lys Leu Asp           
    50                  55                  60                            

cgg ctg ggc aga tcc atg aag cac ctg atc agc ctg gtc gga gag ctg        240
Arg Leu Gly Arg Ser Met Lys His Leu Ile Ser Leu Val Gly Glu Leu           
65                  70                  75                  80            

aga gag cgg ggc atc aac ttc aga agc ctg acc gac agc atc gac acc        288
Arg Glu Arg Gly Ile Asn Phe Arg Ser Leu Thr Asp Ser Ile Asp Thr           
                85                  90                  95                

agc agc cct atg ggc cgg ttc ttc ttc tac gtg atg ggc gcc ctg gcc        336
Ser Ser Pro Met Gly Arg Phe Phe Phe Tyr Val Met Gly Ala Leu Ala           
            100                 105                 110                   

gag atg gaa aga gag ctg atc atc gag cgg aca atg gcc gga ctg gcc        384
Glu Met Glu Arg Glu Leu Ile Ile Glu Arg Thr Met Ala Gly Leu Ala           
        115                 120                 125                       

gct gcc cgg aac aag ggc aga atc ggc ggc aga ccc cct agg ctg acc        432
Ala Ala Arg Asn Lys Gly Arg Ile Gly Gly Arg Pro Pro Arg Leu Thr           
    130                 135                 140                           

aag gcc gag tgg gaa cag gct ggc aga ctg ctg gcc cag gga atc ccc        480
Lys Ala Glu Trp Glu Gln Ala Gly Arg Leu Leu Ala Gln Gly Ile Pro           
145                 150                 155                 160           

cgg aaa cag gtg gcc ctg atc tac gac gtg gcc ctg agc acc ctg tat        528
Arg Lys Gln Val Ala Leu Ile Tyr Asp Val Ala Leu Ser Thr Leu Tyr           
                165                 170                 175               

aag aag cac ccc gcc aag aga gcc cac atc gag aac gac gac cgg atc        576
Lys Lys His Pro Ala Lys Arg Ala His Ile Glu Asn Asp Asp Arg Ile           
            180                 185                 190                   

aac                                                                    579
Asn                                                                       
                                                                          


<210>  2
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Leu Ile Gly Tyr Val Arg Val Ser Thr Asn Asp Gln Asn Thr Asp 
1               5                   10                  15      


Leu Gln Arg Asn Ala Leu Val Cys Ala Gly Cys Glu Gln Ile Phe Glu 
            20                  25                  30          


Asp Lys Leu Ser Gly Thr Arg Thr Asp Arg Pro Gly Leu Lys Arg Ala 
        35                  40                  45              


Leu Lys Arg Leu Gln Lys Gly Asp Thr Leu Val Val Trp Lys Leu Asp 
    50                  55                  60                  


Arg Leu Gly Arg Ser Met Lys His Leu Ile Ser Leu Val Gly Glu Leu 
65                  70                  75                  80  


Arg Glu Arg Gly Ile Asn Phe Arg Ser Leu Thr Asp Ser Ile Asp Thr 
                85                  90                  95      


Ser Ser Pro Met Gly Arg Phe Phe Phe Tyr Val Met Gly Ala Leu Ala 
            100                 105                 110         


Glu Met Glu Arg Glu Leu Ile Ile Glu Arg Thr Met Ala Gly Leu Ala 
        115                 120                 125             


Ala Ala Arg Asn Lys Gly Arg Ile Gly Gly Arg Pro Pro Arg Leu Thr 
    130                 135                 140                 


Lys Ala Glu Trp Glu Gln Ala Gly Arg Leu Leu Ala Gln Gly Ile Pro 
145                 150                 155                 160 


Arg Lys Gln Val Ala Leu Ile Tyr Asp Val Ala Leu Ser Thr Leu Tyr 
                165                 170                 175     


Lys Lys His Pro Ala Lys Arg Ala His Ile Glu Asn Asp Asp Arg Ile 
            180                 185                 190         


Asn 
    


<210>  3
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified Gin enzyme


<220>
<221>  CDS
<222>  (1)..(171)

<400>  3
atg ggc aga ccc cct agg ctg acc aag gcc gag tgg gaa cag gct ggc         48
Met Gly Arg Pro Pro Arg Leu Thr Lys Ala Glu Trp Glu Gln Ala Gly           
1               5                   10                  15                

aga ctg ctg gcc cag gga atc ccc cgg aaa cag gtg gcc ctg atc tac         96
Arg Leu Leu Ala Gln Gly Ile Pro Arg Lys Gln Val Ala Leu Ile Tyr           
            20                  25                  30                    

gac gtg gcc ctg agc acc ctg tat aag aag cac ccc gcc aag aga gcc        144
Asp Val Ala Leu Ser Thr Leu Tyr Lys Lys His Pro Ala Lys Arg Ala           
        35                  40                  45                        

cac atc gag aac gac gac cgg atc aac                                    171
His Ile Glu Asn Asp Asp Arg Ile Asn                                       
    50                  55                                                


<210>  4
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Gly Arg Pro Pro Arg Leu Thr Lys Ala Glu Trp Glu Gln Ala Gly 
1               5                   10                  15      


Arg Leu Leu Ala Gln Gly Ile Pro Arg Lys Gln Val Ala Leu Ile Tyr 
            20                  25                  30          


Asp Val Ala Leu Ser Thr Leu Tyr Lys Lys His Pro Ala Lys Arg Ala 
        35                  40                  45              


His Ile Glu Asn Asp Asp Arg Ile Asn 
    50                  55          


<210>  5
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified enzyme from Gin and FokI


<220>
<221>  CDS
<222>  (1)..(768)

<400>  5
atg ggc aga ccc cct agg ctg acc aag gcc gag tgg gaa cag gct ggc         48
Met Gly Arg Pro Pro Arg Leu Thr Lys Ala Glu Trp Glu Gln Ala Gly           
1               5                   10                  15                

aga ctg ctg gcc cag gga atc ccc cgg aaa cag gtg gcc ctg atc tac         96
Arg Leu Leu Ala Gln Gly Ile Pro Arg Lys Gln Val Ala Leu Ile Tyr           
            20                  25                  30                    

gac gtg gcc ctg agc acc ctg tat aag aag cac ccc gcc aag aga gcc        144
Asp Val Ala Leu Ser Thr Leu Tyr Lys Lys His Pro Ala Lys Arg Ala           
        35                  40                  45                        

cac atc gag aac gac gac cgg atc aac ggt acc aag cag ctg gtg aaa        192
His Ile Glu Asn Asp Asp Arg Ile Asn Gly Thr Lys Gln Leu Val Lys           
    50                  55                  60                            

agc gag ctg gaa gag aag aag tcc gag ctg cgg cac aag ctg aaa tac        240
Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr           
65                  70                  75                  80            

gtg ccc cac gag tac atc gag ctg atc gag atc gcc cgg aac ccc acc        288
Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr           
                85                  90                  95                

cag gac aga atc ctg gaa atg aag gtc atg gaa ttt ttc atg aag gtg        336
Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val           
            100                 105                 110                   

tac ggc tac cgg ggc gag cac ctg ggc ggc agc aga aaa ccc gac ggc        384
Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly           
        115                 120                 125                       

gcc atc tac acc gtg ggc agc ccc atc gac tac ggc gtg atc gtg gac        432
Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp           
    130                 135                 140                           

acc aag gcc tac agc ggc ggc tac aac ctg ccc atc gga cag gcc gac        480
Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp           
145                 150                 155                 160           

gag atg cag aga tac gtg gaa gag aac cag acc cgg aac aag cac atc        528
Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile           
                165                 170                 175               

aac ccc aac gag tgg tgg aag gtg tac ccc agc agc gtg acc gag ttc        576
Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe           
            180                 185                 190                   

aag ttc ctg ttc gtg tcc ggc cac ttc aag ggc aac tac aag gcc cag        624
Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln           
        195                 200                 205                       

ctg acc cgg ctg aac cac atc acc aac tgc aac ggc gct gtg ctg agc        672
Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser           
    210                 215                 220                           

gtg gaa gaa ctg ctg atc ggc ggc gag atg atc aag gcc ggc acc ctg        720
Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu           
225                 230                 235                 240           

acc ctg gaa gaa gtg cgg cgg aag ttc aac aac ggc gag atc aac ttc        768
Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe           
                245                 250                 255               


<210>  6
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Gly Arg Pro Pro Arg Leu Thr Lys Ala Glu Trp Glu Gln Ala Gly 
1               5                   10                  15      


Arg Leu Leu Ala Gln Gly Ile Pro Arg Lys Gln Val Ala Leu Ile Tyr 
            20                  25                  30          


Asp Val Ala Leu Ser Thr Leu Tyr Lys Lys His Pro Ala Lys Arg Ala 
        35                  40                  45              


His Ile Glu Asn Asp Asp Arg Ile Asn Gly Thr Lys Gln Leu Val Lys 
    50                  55                  60                  


Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr 
65                  70                  75                  80  


Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr 
                85                  90                  95      


Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val 
            100                 105                 110         


Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly 
        115                 120                 125             


Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp 
    130                 135                 140                 


Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp 
145                 150                 155                 160 


Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile 
                165                 170                 175     


Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe 
            180                 185                 190         


Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln 
        195                 200                 205             


Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser 
    210                 215                 220                 


Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu 
225                 230                 235                 240 


Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
                245                 250                 255     


<210>  7
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified enzyme from SV40 and Gin


<220>
<221>  CDS
<222>  (1)..(192)

<400>  7
atg ccc aag aag aag aga aag gtg ggc aga ccc cct agg ctg acc aag         48
Met Pro Lys Lys Lys Arg Lys Val Gly Arg Pro Pro Arg Leu Thr Lys           
1               5                   10                  15                

gcc gag tgg gaa cag gct ggc aga ctg ctg gcc cag gga atc ccc cgg         96
Ala Glu Trp Glu Gln Ala Gly Arg Leu Leu Ala Gln Gly Ile Pro Arg           
            20                  25                  30                    

aaa cag gtg gcc ctg atc tac gac gtg gcc ctg agc acc ctg tat aag        144
Lys Gln Val Ala Leu Ile Tyr Asp Val Ala Leu Ser Thr Leu Tyr Lys           
        35                  40                  45                        

aag cac ccc gcc aag aga gcc cac atc gag aac gac gac cgg atc aac        192
Lys His Pro Ala Lys Arg Ala His Ile Glu Asn Asp Asp Arg Ile Asn           
    50                  55                  60                            


<210>  8
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Pro Lys Lys Lys Arg Lys Val Gly Arg Pro Pro Arg Leu Thr Lys 
1               5                   10                  15      


Ala Glu Trp Glu Gln Ala Gly Arg Leu Leu Ala Gln Gly Ile Pro Arg 
            20                  25                  30          


Lys Gln Val Ala Leu Ile Tyr Asp Val Ala Leu Ser Thr Leu Tyr Lys 
        35                  40                  45              


Lys His Pro Ala Lys Arg Ala His Ile Glu Asn Asp Asp Arg Ile Asn 
    50                  55                  60                  


<210>  9
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified enzyme from SV40, Gin and FokI


<220>
<221>  CDS
<222>  (1)..(789)

<400>  9
atg ccc aag aag aag aga aag gtg ggc aga ccc cct agg ctg acc aag         48
Met Pro Lys Lys Lys Arg Lys Val Gly Arg Pro Pro Arg Leu Thr Lys           
1               5                   10                  15                

gcc gag tgg gaa cag gct ggc aga ctg ctg gcc cag gga atc ccc cgg         96
Ala Glu Trp Glu Gln Ala Gly Arg Leu Leu Ala Gln Gly Ile Pro Arg           
            20                  25                  30                    

aaa cag gtg gcc ctg atc tac gac gtg gcc ctg agc acc ctg tat aag        144
Lys Gln Val Ala Leu Ile Tyr Asp Val Ala Leu Ser Thr Leu Tyr Lys           
        35                  40                  45                        

aag cac ccc gcc aag aga gcc cac atc gag aac gac gac cgg atc aac        192
Lys His Pro Ala Lys Arg Ala His Ile Glu Asn Asp Asp Arg Ile Asn           
    50                  55                  60                            

ggt acc aag cag ctg gtg aaa agc gag ctg gaa gag aag aag tcc gag        240
Gly Thr Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu           
65                  70                  75                  80            

ctg cgg cac aag ctg aaa tac gtg ccc cac gag tac atc gag ctg atc        288
Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile           
                85                  90                  95                

gag atc gcc cgg aac ccc acc cag gac aga atc ctg gaa atg aag gtc        336
Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val           
            100                 105                 110                   

atg gaa ttt ttc atg aag gtg tac ggc tac cgg ggc gag cac ctg ggc        384
Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly           
        115                 120                 125                       

ggc agc aga aaa ccc gac ggc gcc atc tac acc gtg ggc agc ccc atc        432
Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile           
    130                 135                 140                           

gac tac ggc gtg atc gtg gac acc aag gcc tac agc ggc ggc tac aac        480
Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn           
145                 150                 155                 160           

ctg ccc atc gga cag gcc gac gag atg cag aga tac gtg gaa gag aac        528
Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn           
                165                 170                 175               

cag acc cgg aac aag cac atc aac ccc aac gag tgg tgg aag gtg tac        576
Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr           
            180                 185                 190                   

ccc agc agc gtg acc gag ttc aag ttc ctg ttc gtg tcc ggc cac ttc        624
Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe           
        195                 200                 205                       

aag ggc aac tac aag gcc cag ctg acc cgg ctg aac cac atc acc aac        672
Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn           
    210                 215                 220                           

tgc aac ggc gct gtg ctg agc gtg gaa gaa ctg ctg atc ggc ggc gag        720
Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu           
225                 230                 235                 240           

atg atc aag gcc ggc acc ctg acc ctg gaa gaa gtg cgg cgg aag ttc        768
Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe           
                245                 250                 255               

aac aac ggc gag atc aac ttc                                            789
Asn Asn Gly Glu Ile Asn Phe                                               
            260                                                           


<210>  10
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Pro Lys Lys Lys Arg Lys Val Gly Arg Pro Pro Arg Leu Thr Lys 
1               5                   10                  15      


Ala Glu Trp Glu Gln Ala Gly Arg Leu Leu Ala Gln Gly Ile Pro Arg 
            20                  25                  30          


Lys Gln Val Ala Leu Ile Tyr Asp Val Ala Leu Ser Thr Leu Tyr Lys 
        35                  40                  45              


Lys His Pro Ala Lys Arg Ala His Ile Glu Asn Asp Asp Arg Ile Asn 
    50                  55                  60                  


Gly Thr Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu 
65                  70                  75                  80  


Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile 
                85                  90                  95      


Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val 
            100                 105                 110         


Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly 
        115                 120                 125             


Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile 
    130                 135                 140                 


Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn 
145                 150                 155                 160 


Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn 
                165                 170                 175     


Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr 
            180                 185                 190         


Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe 
        195                 200                 205             


Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn 
    210                 215                 220                 


Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu 
225                 230                 235                 240 


Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe 
                245                 250                 255     


Asn Asn Gly Glu Ile Asn Phe 
            260             


<210>  11
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified FokI enzyme


<220>
<221>  CDS
<222>  (1)..(1752)

<400>  11
atg ttt ctg agc atg gtg tcc aag atc cgg acc ttc ggc tgg gtg cag         48
Met Phe Leu Ser Met Val Ser Lys Ile Arg Thr Phe Gly Trp Val Gln           
1               5                   10                  15                

aac ccc ggc aag ttc gag aac ctg aag cgg gtg gtg cag gtg ttc gac         96
Asn Pro Gly Lys Phe Glu Asn Leu Lys Arg Val Val Gln Val Phe Asp           
            20                  25                  30                    

cgg aac agc aag gtg cac aac gaa gtg aag aac atc aag atc ccc aca        144
Arg Asn Ser Lys Val His Asn Glu Val Lys Asn Ile Lys Ile Pro Thr           
        35                  40                  45                        

ctg gtg aaa gag agc aag atc cag aaa gaa ctc gtc gcc atc atg aac        192
Leu Val Lys Glu Ser Lys Ile Gln Lys Glu Leu Val Ala Ile Met Asn           
    50                  55                  60                            

cag cac gac ctg atc tac acc tac aaa gaa ctg gtc gga acc ggc acc        240
Gln His Asp Leu Ile Tyr Thr Tyr Lys Glu Leu Val Gly Thr Gly Thr           
65                  70                  75                  80            

agc atc aga agc gag gcc ccc tgc gac gcc atc att cag gcc aca atc        288
Ser Ile Arg Ser Glu Ala Pro Cys Asp Ala Ile Ile Gln Ala Thr Ile           
                85                  90                  95                

gcc gac cag ggc aac aag aag ggc tac atc gac aac tgg tcc agc gac        336
Ala Asp Gln Gly Asn Lys Lys Gly Tyr Ile Asp Asn Trp Ser Ser Asp           
            100                 105                 110                   

ggc ttc ctg aga tgg gcc cac gcc ctg ggc ttc atc gag tac atc aac        384
Gly Phe Leu Arg Trp Ala His Ala Leu Gly Phe Ile Glu Tyr Ile Asn           
        115                 120                 125                       

aag agc gac agc ttc gtg atc acc gac gtg ggc ctg gcc tac agc aag        432
Lys Ser Asp Ser Phe Val Ile Thr Asp Val Gly Leu Ala Tyr Ser Lys           
    130                 135                 140                           

agc gcc gat ggc agc gcc att gag aaa gag atc ctg atc gag gcc atc        480
Ser Ala Asp Gly Ser Ala Ile Glu Lys Glu Ile Leu Ile Glu Ala Ile           
145                 150                 155                 160           

agc agc tac ccc cct gcc atc aga atc ctg acc ctg ctg gaa gat ggc        528
Ser Ser Tyr Pro Pro Ala Ile Arg Ile Leu Thr Leu Leu Glu Asp Gly           
                165                 170                 175               

cag cac ctg acc aag ttc gac ctg ggc aag aac ctg ggc ttc tcc ggc        576
Gln His Leu Thr Lys Phe Asp Leu Gly Lys Asn Leu Gly Phe Ser Gly           
            180                 185                 190                   

gag agc ggc ttc acc agc ctg ccc gag gga atc ctg ctg gac acc ctg        624
Glu Ser Gly Phe Thr Ser Leu Pro Glu Gly Ile Leu Leu Asp Thr Leu           
        195                 200                 205                       

gcc aac gcc atg ccc aag gac aag ggc gag atc cgg aac aac tgg gag        672
Ala Asn Ala Met Pro Lys Asp Lys Gly Glu Ile Arg Asn Asn Trp Glu           
    210                 215                 220                           

ggc agc agc gat aag tac gcc aga atg atc ggc ggc tgg ctg gac aag        720
Gly Ser Ser Asp Lys Tyr Ala Arg Met Ile Gly Gly Trp Leu Asp Lys           
225                 230                 235                 240           

ctg ggc ctg gtc aaa cag ggg aag aaa gag ttc atc att ccc acc ctg        768
Leu Gly Leu Val Lys Gln Gly Lys Lys Glu Phe Ile Ile Pro Thr Leu           
                245                 250                 255               

ggc aag ccc gac aac aaa gag ttt atc agc cac gcc ttc aag atc aca        816
Gly Lys Pro Asp Asn Lys Glu Phe Ile Ser His Ala Phe Lys Ile Thr           
            260                 265                 270                   

ggc gag ggc ctg aag gtg ctg cgg aga gcc aag ggc agc acc aag ttc        864
Gly Glu Gly Leu Lys Val Leu Arg Arg Ala Lys Gly Ser Thr Lys Phe           
        275                 280                 285                       

aca cgg gtg ccc aag cgg gtg tac tgg gag atg ctg gcc acc aac ctg        912
Thr Arg Val Pro Lys Arg Val Tyr Trp Glu Met Leu Ala Thr Asn Leu           
    290                 295                 300                           

acc gac aaa gaa tac gtg cgg acc aga cgg gcc ctg atc ctg gaa atc        960
Thr Asp Lys Glu Tyr Val Arg Thr Arg Arg Ala Leu Ile Leu Glu Ile           
305                 310                 315                 320           

ctg att aag gcc ggc agc ctg aag atc gag cag atc cag gac aac ctg       1008
Leu Ile Lys Ala Gly Ser Leu Lys Ile Glu Gln Ile Gln Asp Asn Leu           
                325                 330                 335               

aag aag ctg ggc ttt gac gaa gtg atc gag aca atc gag aac gac atc       1056
Lys Lys Leu Gly Phe Asp Glu Val Ile Glu Thr Ile Glu Asn Asp Ile           
            340                 345                 350                   

aag ggc ctg atc aac acc ggc atc ttc atc gag atc aag ggc cgg ttc       1104
Lys Gly Leu Ile Asn Thr Gly Ile Phe Ile Glu Ile Lys Gly Arg Phe           
        355                 360                 365                       

tac cag ctg aag gac cac att ctg cag ttc gtg atc ccc aac cgg gga       1152
Tyr Gln Leu Lys Asp His Ile Leu Gln Phe Val Ile Pro Asn Arg Gly           
    370                 375                 380                           

gtg ggt acc aag cag ctg gtg aaa agc gag ctg gaa gag aag aag tcc       1200
Val Gly Thr Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser           
385                 390                 395                 400           

gag ctg cgg cac aag ctg aaa tac gtg ccc cac gag tac atc gag ctg       1248
Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu           
                405                 410                 415               

atc gag atc gcc cgg aac ccc acc cag gac aga atc ctg gaa atg aag       1296
Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys           
            420                 425                 430                   

gtc atg gaa ttt ttc atg aag gtg tac ggc tac cgg ggc gag cac ctg       1344
Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu           
        435                 440                 445                       

ggc ggc agc aga aaa ccc gac ggc gcc atc tac acc gtg ggc agc ccc       1392
Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro           
    450                 455                 460                           

atc gac tac ggc gtg atc gtg gac acc aag gcc tac agc ggc ggc tac       1440
Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr           
465                 470                 475                 480           

aac ctg ccc atc gga cag gcc gac gag atg cag aga tac gtg gaa gag       1488
Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu           
                485                 490                 495               

aac cag acc cgg aac aag cac atc aac ccc aac gag tgg tgg aag gtg       1536
Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val           
            500                 505                 510                   

tac ccc agc agc gtg acc gag ttc aag ttc ctg ttc gtg tcc ggc cac       1584
Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His           
        515                 520                 525                       

ttc aag ggc aac tac aag gcc cag ctg acc cgg ctg aac cac atc acc       1632
Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr           
    530                 535                 540                           

aac tgc aac ggc gct gtg ctg agc gtg gaa gaa ctg ctg atc ggc ggc       1680
Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly           
545                 550                 555                 560           

gag atg atc aag gcc ggc acc ctg acc ctg gaa gaa gtg cgg cgg aag       1728
Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys           
                565                 570                 575               

ttc aac aac ggc gag atc aac ttc                                       1752
Phe Asn Asn Gly Glu Ile Asn Phe                                           
            580                                                           


<210>  12
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Phe Leu Ser Met Val Ser Lys Ile Arg Thr Phe Gly Trp Val Gln 
1               5                   10                  15      


Asn Pro Gly Lys Phe Glu Asn Leu Lys Arg Val Val Gln Val Phe Asp 
            20                  25                  30          


Arg Asn Ser Lys Val His Asn Glu Val Lys Asn Ile Lys Ile Pro Thr 
        35                  40                  45              


Leu Val Lys Glu Ser Lys Ile Gln Lys Glu Leu Val Ala Ile Met Asn 
    50                  55                  60                  


Gln His Asp Leu Ile Tyr Thr Tyr Lys Glu Leu Val Gly Thr Gly Thr 
65                  70                  75                  80  


Ser Ile Arg Ser Glu Ala Pro Cys Asp Ala Ile Ile Gln Ala Thr Ile 
                85                  90                  95      


Ala Asp Gln Gly Asn Lys Lys Gly Tyr Ile Asp Asn Trp Ser Ser Asp 
            100                 105                 110         


Gly Phe Leu Arg Trp Ala His Ala Leu Gly Phe Ile Glu Tyr Ile Asn 
        115                 120                 125             


Lys Ser Asp Ser Phe Val Ile Thr Asp Val Gly Leu Ala Tyr Ser Lys 
    130                 135                 140                 


Ser Ala Asp Gly Ser Ala Ile Glu Lys Glu Ile Leu Ile Glu Ala Ile 
145                 150                 155                 160 


Ser Ser Tyr Pro Pro Ala Ile Arg Ile Leu Thr Leu Leu Glu Asp Gly 
                165                 170                 175     


Gln His Leu Thr Lys Phe Asp Leu Gly Lys Asn Leu Gly Phe Ser Gly 
            180                 185                 190         


Glu Ser Gly Phe Thr Ser Leu Pro Glu Gly Ile Leu Leu Asp Thr Leu 
        195                 200                 205             


Ala Asn Ala Met Pro Lys Asp Lys Gly Glu Ile Arg Asn Asn Trp Glu 
    210                 215                 220                 


Gly Ser Ser Asp Lys Tyr Ala Arg Met Ile Gly Gly Trp Leu Asp Lys 
225                 230                 235                 240 


Leu Gly Leu Val Lys Gln Gly Lys Lys Glu Phe Ile Ile Pro Thr Leu 
                245                 250                 255     


Gly Lys Pro Asp Asn Lys Glu Phe Ile Ser His Ala Phe Lys Ile Thr 
            260                 265                 270         


Gly Glu Gly Leu Lys Val Leu Arg Arg Ala Lys Gly Ser Thr Lys Phe 
        275                 280                 285             


Thr Arg Val Pro Lys Arg Val Tyr Trp Glu Met Leu Ala Thr Asn Leu 
    290                 295                 300                 


Thr Asp Lys Glu Tyr Val Arg Thr Arg Arg Ala Leu Ile Leu Glu Ile 
305                 310                 315                 320 


Leu Ile Lys Ala Gly Ser Leu Lys Ile Glu Gln Ile Gln Asp Asn Leu 
                325                 330                 335     


Lys Lys Leu Gly Phe Asp Glu Val Ile Glu Thr Ile Glu Asn Asp Ile 
            340                 345                 350         


Lys Gly Leu Ile Asn Thr Gly Ile Phe Ile Glu Ile Lys Gly Arg Phe 
        355                 360                 365             


Tyr Gln Leu Lys Asp His Ile Leu Gln Phe Val Ile Pro Asn Arg Gly 
    370                 375                 380                 


Val Gly Thr Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser 
385                 390                 395                 400 


Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu 
                405                 410                 415     


Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys 
            420                 425                 430         


Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu 
        435                 440                 445             


Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro 
    450                 455                 460                 


Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr 
465                 470                 475                 480 


Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu 
                485                 490                 495     


Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val 
            500                 505                 510         


Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His 
        515                 520                 525             


Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr 
    530                 535                 540                 


Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly 
545                 550                 555                 560 


Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys 
                565                 570                 575     


Phe Asn Asn Gly Glu Ile Asn Phe 
            580                 


<210>  13
<211>  594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified FokI enzyme


<220>
<221>  CDS
<222>  (1)..(594)

<400>  13
atg aag cag ctg gtg aaa agc gag ctg gaa gag aag aag tcc gag ctg         48
Met Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu           
1               5                   10                  15                

cgg cac aag ctg aaa tac gtg ccc cac gag tac atc gag ctg atc gag         96
Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu           
            20                  25                  30                    

atc gcc cgg aac ccc acc cag gac aga atc ctg gaa atg aag gtc atg        144
Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met           
        35                  40                  45                        

gaa ttt ttc atg aag gtg tac ggc tac cgg ggc gag cac ctg ggc ggc        192
Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly           
    50                  55                  60                            

agc aga aaa ccc gac ggc gcc atc tac acc gtg ggc agc ccc atc gac        240
Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp           
65                  70                  75                  80            

tac ggc gtg atc gtg gac acc aag gcc tac agc ggc ggc tac aac ctg        288
Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu           
                85                  90                  95                

ccc atc gga cag gcc gac gag atg cag aga tac gtg gaa gag aac cag        336
Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln           
            100                 105                 110                   

acc cgg aac aag cac atc aac ccc aac gag tgg tgg aag gtg tac ccc        384
Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro           
        115                 120                 125                       

agc agc gtg acc gag ttc aag ttc ctg ttc gtg tcc ggc cac ttc aag        432
Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys           
    130                 135                 140                           

ggc aac tac aag gcc cag ctg acc cgg ctg aac cac atc acc aac tgc        480
Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys           
145                 150                 155                 160           

aac ggc gct gtg ctg agc gtg gaa gaa ctg ctg atc ggc ggc gag atg        528
Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met           
                165                 170                 175               

atc aag gcc ggc acc ctg acc ctg gaa gaa gtg cgg cgg aag ttc aac        576
Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn           
            180                 185                 190                   

aac ggc gag atc aac ttc                                                594
Asn Gly Glu Ile Asn Phe                                                   
        195                                                               


<210>  14
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
1               5                   10                  15      


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
            20                  25                  30          


Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
        35                  40                  45              


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly 
    50                  55                  60                  


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
65                  70                  75                  80  


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
                85                  90                  95      


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
            100                 105                 110         


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
        115                 120                 125             


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
    130                 135                 140                 


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
145                 150                 155                 160 


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
                165                 170                 175     


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
            180                 185                 190         


Asn Gly Glu Ile Asn Phe 
        195             


<210>  15
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified enzyme from SV40 and FokI


<220>
<221>  CDS
<222>  (1)..(615)

<400>  15
atg ccc aag aag aag aga aag gtg aag cag ctg gtg aaa agc gag ctg         48
Met Pro Lys Lys Lys Arg Lys Val Lys Gln Leu Val Lys Ser Glu Leu           
1               5                   10                  15                

gaa gag aag aag tcc gag ctg cgg cac aag ctg aaa tac gtg ccc cac         96
Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His           
            20                  25                  30                    

gag tac atc gag ctg atc gag atc gcc cgg aac ccc acc cag gac aga        144
Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg           
        35                  40                  45                        

atc ctg gaa atg aag gtc atg gaa ttt ttc atg aag gtg tac ggc tac        192
Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr           
    50                  55                  60                            

cgg ggc gag cac ctg ggc ggc agc aga aaa ccc gac ggc gcc atc tac        240
Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr           
65                  70                  75                  80            

acc gtg ggc agc ccc atc gac tac ggc gtg atc gtg gac acc aag gcc        288
Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala           
                85                  90                  95                

tac agc ggc ggc tac aac ctg ccc atc gga cag gcc gac gag atg cag        336
Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln           
            100                 105                 110                   

aga tac gtg gaa gag aac cag acc cgg aac aag cac atc aac ccc aac        384
Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn           
        115                 120                 125                       

gag tgg tgg aag gtg tac ccc agc agc gtg acc gag ttc aag ttc ctg        432
Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu           
    130                 135                 140                           

ttc gtg tcc ggc cac ttc aag ggc aac tac aag gcc cag ctg acc cgg        480
Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg           
145                 150                 155                 160           

ctg aac cac atc acc aac tgc aac ggc gct gtg ctg agc gtg gaa gaa        528
Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu           
                165                 170                 175               

ctg ctg atc ggc ggc gag atg atc aag gcc ggc acc ctg acc ctg gaa        576
Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu           
            180                 185                 190                   

gaa gtg cgg cgg aag ttc aac aac ggc gag atc aac ttc                    615
Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe                       
        195                 200                 205                       


<210>  16
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Pro Lys Lys Lys Arg Lys Val Lys Gln Leu Val Lys Ser Glu Leu 
1               5                   10                  15      


Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His 
            20                  25                  30          


Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg 
        35                  40                  45              


Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr 
    50                  55                  60                  


Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr 
65                  70                  75                  80  


Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala 
                85                  90                  95      


Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln 
            100                 105                 110         


Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn 
        115                 120                 125             


Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu 
    130                 135                 140                 


Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg 
145                 150                 155                 160 


Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu 
                165                 170                 175     


Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu 
            180                 185                 190         


Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe 
        195                 200                 205 


<210>  17
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified ZFHD enzyme


<220>
<221>  CDS
<222>  (1)..(366)

<400>  17
atg gag aga ccc tac gcc tgc ccc gtg gag agc tgc gac aga aga ttc         48
Met Glu Arg Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe           
1               5                   10                  15                

agc aga agc gac gag ctg acc aga cac atc aga atc cac acc ggc cag         96
Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln           
            20                  25                  30                    

aag ccc ttc cag tgc aga atc tgc atg aga aac ttc agc aga agc gac        144
Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp           
        35                  40                  45                        

cac ctg acc acc cac atc aga acc cac aca ggc ggc ggc aga aga aga        192
His Leu Thr Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg           
    50                  55                  60                            

aag aag aga acc agc atc gag acc aac atc aga gtg gcc ctg gag aaa        240
Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys           
65                  70                  75                  80            

agc ttc ctg gag aac cag aag ccc acc agc gag gag atc acc atg atc        288
Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile           
                85                  90                  95                

gcc gac cag ctg aac atg gag aag gag gtg atc aga gtg tgg ttc tgc        336
Ala Asp Gln Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys           
            100                 105                 110                   

aac aga aga cag aag gag aag aga atc aac                                366
Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn                                   
        115                 120                                           


<210>  18
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Glu Arg Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe 
1               5                   10                  15      


Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln 
            20                  25                  30          


Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp 
        35                  40                  45              


His Leu Thr Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg 
    50                  55                  60                  


Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys 
65                  70                  75                  80  


Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile 
                85                  90                  95      


Ala Asp Gln Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys 
            100                 105                 110         


Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn 
        115                 120         


<210>  19
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified enzyme from SV40 and ZFHD


<220>
<221>  CDS
<222>  (1)..(387)

<400>  19
atg ccc aag aag aag aga aag gtg gag aga ccc tac gcc tgc ccc gtg         48
Met Pro Lys Lys Lys Arg Lys Val Glu Arg Pro Tyr Ala Cys Pro Val           
1               5                   10                  15                

gag agc tgc gac aga aga ttc agc aga agc gac gag ctg acc aga cac         96
Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg His           
            20                  25                  30                    

atc aga atc cac acc ggc cag aag ccc ttc cag tgc aga atc tgc atg        144
Ile Arg Ile His Thr Gly Gln Lys Pro Phe Gln Cys Arg Ile Cys Met           
        35                  40                  45                        

aga aac ttc agc aga agc gac cac ctg acc acc cac atc aga acc cac        192
Arg Asn Phe Ser Arg Ser Asp His Leu Thr Thr His Ile Arg Thr His           
    50                  55                  60                            

aca ggc ggc ggc aga aga aga aag aag aga acc agc atc gag acc aac        240
Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn           
65                  70                  75                  80            

atc aga gtg gcc ctg gag aaa agc ttc ctg gag aac cag aag ccc acc        288
Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr           
                85                  90                  95                

agc gag gag atc acc atg atc gcc gac cag ctg aac atg gag aag gag        336
Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys Glu           
            100                 105                 110                   

gtg atc aga gtg tgg ttc tgc aac aga aga cag aag gag aag aga atc        384
Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile           
        115                 120                 125                       

aac                                                                    387
Asn                                                                       
                                                                          


<210>  20
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Pro Lys Lys Lys Arg Lys Val Glu Arg Pro Tyr Ala Cys Pro Val 
1               5                   10                  15      


Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg His 
            20                  25                  30          


Ile Arg Ile His Thr Gly Gln Lys Pro Phe Gln Cys Arg Ile Cys Met 
        35                  40                  45              


Arg Asn Phe Ser Arg Ser Asp His Leu Thr Thr His Ile Arg Thr His 
    50                  55                  60                  


Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn 
65                  70                  75                  80  


Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr 
                85                  90                  95      


Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys Glu 
            100                 105                 110         


Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile 
        115                 120                 125             


Asn 
    


<210>  21
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified enzyme from ZFHD and FokI


<220>
<221>  CDS
<222>  (1)..(963)

<400>  21
atg gag aga ccc tac gcc tgc ccc gtg gag agc tgc gac aga aga ttc         48
Met Glu Arg Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe           
1               5                   10                  15                

agc aga agc gac gag ctg acc aga cac atc aga atc cac acc ggc cag         96
Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln           
            20                  25                  30                    

aag ccc ttc cag tgc aga atc tgc atg aga aac ttc agc aga agc gac        144
Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp           
        35                  40                  45                        

cac ctg acc acc cac atc aga acc cac aca ggc ggc ggc aga aga aga        192
His Leu Thr Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg           
    50                  55                  60                            

aag aag aga acc agc atc gag acc aac atc aga gtg gcc ctg gag aaa        240
Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys           
65                  70                  75                  80            

agc ttc ctg gag aac cag aag ccc acc agc gag gag atc acc atg atc        288
Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile           
                85                  90                  95                

gcc gac cag ctg aac atg gag aag gag gtg atc aga gtg tgg ttc tgc        336
Ala Asp Gln Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys           
            100                 105                 110                   

aac aga aga cag aag gag aag aga atc aac ggt acc aag cag ctg gtg        384
Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn Gly Thr Lys Gln Leu Val           
        115                 120                 125                       

aaa agc gag ctg gaa gag aag aag tcc gag ctg cgg cac aag ctg aaa        432
Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys           
    130                 135                 140                           

tac gtg ccc cac gag tac atc gag ctg atc gag atc gcc cgg aac ccc        480
Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro           
145                 150                 155                 160           

acc cag gac aga atc ctg gaa atg aag gtc atg gaa ttt ttc atg aag        528
Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys           
                165                 170                 175               

gtg tac ggc tac cgg ggc gag cac ctg ggc ggc agc aga aaa ccc gac        576
Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp           
            180                 185                 190                   

ggc gcc atc tac acc gtg ggc agc ccc atc gac tac ggc gtg atc gtg        624
Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val           
        195                 200                 205                       

gac acc aag gcc tac agc ggc ggc tac aac ctg ccc atc gga cag gcc        672
Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala           
    210                 215                 220                           

gac gag atg cag aga tac gtg gaa gag aac cag acc cgg aac aag cac        720
Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His           
225                 230                 235                 240           

atc aac ccc aac gag tgg tgg aag gtg tac ccc agc agc gtg acc gag        768
Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu           
                245                 250                 255               

ttc aag ttc ctg ttc gtg tcc ggc cac ttc aag ggc aac tac aag gcc        816
Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala           
            260                 265                 270                   

cag ctg acc cgg ctg aac cac atc acc aac tgc aac ggc gct gtg ctg        864
Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu           
        275                 280                 285                       

agc gtg gaa gaa ctg ctg atc ggc ggc gag atg atc aag gcc ggc acc        912
Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr           
    290                 295                 300                           

ctg acc ctg gaa gaa gtg cgg cgg aag ttc aac aac ggc gag atc aac        960
Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn           
305                 310                 315                 320           

ttc                                                                    963
Phe                                                                       
                                                                          


<210>  22
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Glu Arg Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe 
1               5                   10                  15      


Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln 
            20                  25                  30          


Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp 
        35                  40                  45              


His Leu Thr Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg 
    50                  55                  60                  


Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys 
65                  70                  75                  80  


Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile 
                85                  90                  95      


Ala Asp Gln Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys 
            100                 105                 110         


Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn Gly Thr Lys Gln Leu Val 
        115                 120                 125             


Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys 
    130                 135                 140                 


Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro 
145                 150                 155                 160 


Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys 
                165                 170                 175     


Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp 
            180                 185                 190         


Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val 
        195                 200                 205             


Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala 
    210                 215                 220                 


Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His 
225                 230                 235                 240 


Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu 
                245                 250                 255     


Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala 
            260                 265                 270         


Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu 
        275                 280                 285             


Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr 
    290                 295                 300                 


Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn 
305                 310                 315                 320 


Phe 
    


<210>  23
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified enzyme from SV40, ZFHD and FokI


<220>
<221>  CDS
<222>  (1)..(984)

<400>  23
atg ccc aag aag aag aga aag gtg gag aga ccc tac gcc tgc ccc gtg         48
Met Pro Lys Lys Lys Arg Lys Val Glu Arg Pro Tyr Ala Cys Pro Val           
1               5                   10                  15                

gag agc tgc gac aga aga ttc agc aga agc gac gag ctg acc aga cac         96
Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg His           
            20                  25                  30                    

atc aga atc cac acc ggc cag aag ccc ttc cag tgc aga atc tgc atg        144
Ile Arg Ile His Thr Gly Gln Lys Pro Phe Gln Cys Arg Ile Cys Met           
        35                  40                  45                        

aga aac ttc agc aga agc gac cac ctg acc acc cac atc aga acc cac        192
Arg Asn Phe Ser Arg Ser Asp His Leu Thr Thr His Ile Arg Thr His           
    50                  55                  60                            

aca ggc ggc ggc aga aga aga aag aag aga acc agc atc gag acc aac        240
Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn           
65                  70                  75                  80            

atc aga gtg gcc ctg gag aaa agc ttc ctg gag aac cag aag ccc acc        288
Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr           
                85                  90                  95                

agc gag gag atc acc atg atc gcc gac cag ctg aac atg gag aag gag        336
Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys Glu           
            100                 105                 110                   

gtg atc aga gtg tgg ttc tgc aac aga aga cag aag gag aag aga atc        384
Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile           
        115                 120                 125                       

aac ggt acc aag cag ctg gtg aaa agc gag ctg gaa gag aag aag tcc        432
Asn Gly Thr Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser           
    130                 135                 140                           

gag ctg cgg cac aag ctg aaa tac gtg ccc cac gag tac atc gag ctg        480
Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu           
145                 150                 155                 160           

atc gag atc gcc cgg aac ccc acc cag gac aga atc ctg gaa atg aag        528
Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys           
                165                 170                 175               

gtc atg gaa ttt ttc atg aag gtg tac ggc tac cgg ggc gag cac ctg        576
Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu           
            180                 185                 190                   

ggc ggc agc aga aaa ccc gac ggc gcc atc tac acc gtg ggc agc ccc        624
Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro           
        195                 200                 205                       

atc gac tac ggc gtg atc gtg gac acc aag gcc tac agc ggc ggc tac        672
Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr           
    210                 215                 220                           

aac ctg ccc atc gga cag gcc gac gag atg cag aga tac gtg gaa gag        720
Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu           
225                 230                 235                 240           

aac cag acc cgg aac aag cac atc aac ccc aac gag tgg tgg aag gtg        768
Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val           
                245                 250                 255               

tac ccc agc agc gtg acc gag ttc aag ttc ctg ttc gtg tcc ggc cac        816
Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His           
            260                 265                 270                   

ttc aag ggc aac tac aag gcc cag ctg acc cgg ctg aac cac atc acc        864
Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr           
        275                 280                 285                       

aac tgc aac ggc gct gtg ctg agc gtg gaa gaa ctg ctg atc ggc ggc        912
Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly           
    290                 295                 300                           

gag atg atc aag gcc ggc acc ctg acc ctg gaa gaa gtg cgg cgg aag        960
Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys           
305                 310                 315                 320           

ttc aac aac ggc gag atc aac ttc                                        984
Phe Asn Asn Gly Glu Ile Asn Phe                                           
                325                                                       


<210>  24
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Pro Lys Lys Lys Arg Lys Val Glu Arg Pro Tyr Ala Cys Pro Val 
1               5                   10                  15      


Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg His 
            20                  25                  30          


Ile Arg Ile His Thr Gly Gln Lys Pro Phe Gln Cys Arg Ile Cys Met 
        35                  40                  45              


Arg Asn Phe Ser Arg Ser Asp His Leu Thr Thr His Ile Arg Thr His 
    50                  55                  60                  


Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn 
65                  70                  75                  80  


Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr 
                85                  90                  95      


Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys Glu 
            100                 105                 110         


Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile 
        115                 120                 125             


Asn Gly Thr Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser 
    130                 135                 140                 


Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu 
145                 150                 155                 160 


Ile Glu Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys 
                165                 170                 175     


Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu 
            180                 185                 190         


Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro 
        195                 200                 205             


Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr 
    210                 215                 220                 


Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu 
225                 230                 235                 240 


Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val 
                245                 250                 255     


Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His 
            260                 265                 270         


Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr 
        275                 280                 285             


Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly 
    290                 295                 300                 


Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys 
305                 310                 315                 320 


Phe Asn Asn Gly Glu Ile Asn Phe 
                325             


<210>  25
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  25
tagggataac agggtaat                                                     18


<210>  26
<211>  168
<212>  DNA
<213>  adeno-associated virus 2

<400>  26
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacg                   168


<210>  27
<211>  832
<212>  DNA
<213>  Unknown

<220>
<223>  cytomegalovirus

<400>  27
taggaagatc ttcaatattg gccattagcc atattattca ttggttatat agcataaatc       60

aatattggct attggccatt gcatacgttg tatctatatc ataatatgta catttatatt      120

ggctcatgtc caatatgacc gccatgttgg cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      780

cacagttaaa ttgctaacgc agtcagtgct tctgacacaa cagtctcgaa ct              832


<210>  28
<211>  173
<212>  DNA
<213>  Unknown

<220>
<223>  cytomegalovirus

<400>  28
actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc       60

aaaatcaacg ggactttcca aaatgtcgta ataaccccgc cccgttgacg caaatgggcg      120

gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac cgt             173


<210>  29
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from c-Myc NLS, FRAP and Homo sapiens


<220>
<221>  CDS
<222>  (1)..(900)

<400>  29
atg gac tat cct gct gcc aag agg gtc aag ttg gac tct aga atc ctc         48
Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Ile Leu           
1               5                   10                  15                

tgg cat gag atg tgg cat gaa ggc ctg gaa gag gca tct cgt ttg tac         96
Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr           
            20                  25                  30                    

ttt ggg gaa agg aac gtg aaa ggc atg ttt gag gtg ctg gag ccc ttg        144
Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu           
        35                  40                  45                        

cat gct atg atg gaa cgg ggc ccc cag act ctg aag gaa aca tcc ttt        192
His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe           
    50                  55                  60                            

aat cag gcc tat ggt cga gat tta atg gag gcc caa gag tgg tgc agg        240
Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg           
65                  70                  75                  80            

aag tac atg aaa tca ggg aat gtc aag gac ctc ctc caa gcc tgg gac        288
Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp           
                85                  90                  95                

ctc tat tat cat gtg ttc cga cga atc tca aag act aga gat gag ttt        336
Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Arg Asp Glu Phe           
            100                 105                 110                   

ccc acc atg gtg ttt cct tct ggg cag atc agc cag gcc tcg gcc ttg        384
Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu           
        115                 120                 125                       

gcc ccg gcc cct ccc caa gtc ctg ccc cag gct cca gcc cct gcc cct        432
Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro           
    130                 135                 140                           

gct cca gcc atg gta tca gct ctg gcc cag gcc cca gcc cct gtc cca        480
Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro           
145                 150                 155                 160           

gtc cta gcc cca ggc cct cct cag gct gtg gcc cca cct gcc ccc aag        528
Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys           
                165                 170                 175               

ccc acc cag gct ggg gaa gga acg ctg tca gag gcc ctg ctg cag ctg        576
Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu           
            180                 185                 190                   

cag ttt gat gat gaa gac ctg ggg gcc ttg ctt ggc aac agc aca gac        624
Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp           
        195                 200                 205                       

cca gct gtg ttc aca gac ctg gca tcc gtc gac aac tcc gag ttt cag        672
Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln           
    210                 215                 220                           

cag ctg ctg aac cag ggc ata cct gtg gcc ccc cac aca act gag ccc        720
Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro           
225                 230                 235                 240           

atg ctg atg gag tac cct gag gct ata act cgc cta gtg aca ggg gcc        768
Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala           
                245                 250                 255               

cag agg ccc ccc gac cca gct cct gct cca ctg ggg gcc ccg ggg ctc        816
Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu           
            260                 265                 270                   

ccc aat ggc ctc ctt tca gga gat gaa gac ttc tcc tcc att gcg gac        864
Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp           
        275                 280                 285                       

atg gac ttc tca gcc ctg ctg agt cag atc agc tcc                        900
Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser                           
    290                 295                 300                           


<210>  30
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Ile Leu 
1               5                   10                  15      


Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr 
            20                  25                  30          


Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val Leu Glu Pro Leu 
        35                  40                  45              


His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe 
    50                  55                  60                  


Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln Glu Trp Cys Arg 
65                  70                  75                  80  


Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu Gln Ala Trp Asp 
                85                  90                  95      


Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Thr Arg Asp Glu Phe 
            100                 105                 110         


Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu 
        115                 120                 125             


Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro 
    130                 135                 140                 


Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro 
145                 150                 155                 160 


Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys 
                165                 170                 175     


Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu 
            180                 185                 190         


Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp 
        195                 200                 205             


Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln 
    210                 215                 220                 


Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro 
225                 230                 235                 240 


Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala 
                245                 250                 255     


Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu 
            260                 265                 270         


Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp 
        275                 280                 285             


Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser 
    290                 295                 300 


<210>  31
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from insect virus

<400>  31
gagggccgcg gaagcttact aacatgcggt gacgtcgagg agaacccggg ccct             54


<210>  32
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from zinc finger homeodomain and human IL-2 
       minimal promoter

<400>  32
aatgatgggc gctcgagtaa tgatgggcgg tcgactaatg atgggcgctc gagtaatgat       60

gggcgtctag ctaatgatgg gcgctcgagt aatgatgggc ggtcgactaa tgatgggcgc      120

tcgagtaatg atgggcgtct agaac                                            145


<210>  33
<211>  1029
<212>  DNA
<213>  Bacteriophage P1


<220>
<221>  CDS
<222>  (1)..(1029)

<400>  33
atg tcc aat tta ctg acc gta cac caa aat ttg cct gca tta ccg gtc         48
Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val           
1               5                   10                  15                

gat gca acg agt gat gag gtt cgc aag aac ctg atg gac atg ttc agg         96
Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg           
            20                  25                  30                    

gat cgc cag gcg ttt tct gag cat acc tgg aaa atg ctt ctg tcc gtt        144
Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val           
        35                  40                  45                        

tgc cgg tcg tgg gcg gca tgg tgc aag ttg aat aac cgg aaa tgg ttt        192
Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe           
    50                  55                  60                            

ccc gca gaa cct gaa gat gtt cgc gat tat ctt cta tat ctt cag gcg        240
Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala           
65                  70                  75                  80            

cgc ggt ctg gca gta aaa act atc cag caa cat ttg ggc cag cta aac        288
Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn           
                85                  90                  95                

atg ctt cat cgt cgg tcc ggg ctg cca cga cca agt gac agc aat gct        336
Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala           
            100                 105                 110                   

gtt tca ctg gtt atg cgg cgg atc cga aaa gaa aac gtt gat gcc ggt        384
Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly           
        115                 120                 125                       

gaa cgt gca aaa cag gct cta gcg ttc gaa cgc act gat ttc gac cag        432
Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln           
    130                 135                 140                           

gtt cgt tca ctc atg gaa aat agc gat cgc tgc cag gat ata cgt aat        480
Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn           
145                 150                 155                 160           

ctg gca ttt ctg ggg att gct tat aac acc ctg tta cgt ata gcc gaa        528
Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu           
                165                 170                 175               

att gcc agg atc agg gtt aaa gat atc tca cgt act gac ggt ggg aga        576
Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg           
            180                 185                 190                   

atg tta atc cat att ggc aga acg aaa acg ctg gtt agc acc gca ggt        624
Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly           
        195                 200                 205                       

gta gag aag gca ctt agc ctg ggg gta act aaa ctg gtc gag cga tgg        672
Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp           
    210                 215                 220                           

att tcc gtc tct ggt gta gct gat gat ccg aat aac tac ctg ttt tgc        720
Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys           
225                 230                 235                 240           

cgg gtc aga aaa aat ggt gtt gcc gcg cca tct gcc acc agc cag cta        768
Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu           
                245                 250                 255               

tca act cgc gcc ctg gaa ggg att ttt gaa gca act cat cga ttg att        816
Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile           
            260                 265                 270                   

tac ggc gct aag gat gac tct ggt cag aga tac ctg gcc tgg tct gga        864
Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly           
        275                 280                 285                       

cac agt gcc cgt gtc gga gcc gcg cga gat atg gcc cgc gct gga gtt        912
His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val           
    290                 295                 300                           

tca ata ccg gag atc atg caa gct ggt ggc tgg acc aat gta aat att        960
Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile           
305                 310                 315                 320           

gtc atg aac tat atc cgt aac ctg gat agt gaa aca ggg gca atg gtg       1008
Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val           
                325                 330                 335               

cgc ctg ctg gaa gat ggc gat                                           1029
Arg Leu Leu Glu Asp Gly Asp                                               
            340                                                           


<210>  34
<211>  343
<212>  PRT
<213>  Bacteriophage P1

<400>  34

Met Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe 
    50                  55                  60                  


Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala 
65                  70                  75                  80  


Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn 
                85                  90                  95      


Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala 
            100                 105                 110         


Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly 
        115                 120                 125             


Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln 
    130                 135                 140                 


Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn 
145                 150                 155                 160 


Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu 
                165                 170                 175     


Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg 
            180                 185                 190         


Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly 
        195                 200                 205             


Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp 
    210                 215                 220                 


Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys 
225                 230                 235                 240 


Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu 
                245                 250                 255     


Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile 
            260                 265                 270         


Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly 
        275                 280                 285             


His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val 
    290                 295                 300                 


Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile 
305                 310                 315                 320 


Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val 
                325                 330                 335     


Arg Leu Leu Glu Asp Gly Asp 
            340             


<210>  35
<211>  705
<212>  DNA
<213>  Unknown

<220>
<223>  yeast endonuclease


<220>
<221>  CDS
<222>  (1)..(705)

<400>  35
atg aag aac att aag aaa aat cag gtc atc aac ctg ggg ccc att tcc         48
Met Lys Asn Ile Lys Lys Asn Gln Val Ile Asn Leu Gly Pro Ile Ser           
1               5                   10                  15                

aag ctg ctg aaa gag tac aag tct cag ctg atc gaa ctg aat att gag         96
Lys Leu Leu Lys Glu Tyr Lys Ser Gln Leu Ile Glu Leu Asn Ile Glu           
            20                  25                  30                    

cag ttt gaa gca ggg atc ggc ctg att ctg ggc gac gcc tac atc agg        144
Gln Phe Glu Ala Gly Ile Gly Leu Ile Leu Gly Asp Ala Tyr Ile Arg           
        35                  40                  45                        

agc aga gat gag gga aag acc tat tgc atg cag ttc gaa tgg aag aac        192
Ser Arg Asp Glu Gly Lys Thr Tyr Cys Met Gln Phe Glu Trp Lys Asn           
    50                  55                  60                            

aaa gct tac atg gac cac gtg tgc ctg ctg tat gat cag tgg gtc ctg        240
Lys Ala Tyr Met Asp His Val Cys Leu Leu Tyr Asp Gln Trp Val Leu           
65                  70                  75                  80            

tct ccc cct cac aag aaa gag cgg gtg aat cat ctg gga aac ctg gtc        288
Ser Pro Pro His Lys Lys Glu Arg Val Asn His Leu Gly Asn Leu Val           
                85                  90                  95                

att act tgg ggg gca cag acc ttc aag cat cag gcc ttc aac aag ctg        336
Ile Thr Trp Gly Ala Gln Thr Phe Lys His Gln Ala Phe Asn Lys Leu           
            100                 105                 110                   

gct aac ctg ttt att gtg aac aat aag aag ctg atc cct aac aat ctg        384
Ala Asn Leu Phe Ile Val Asn Asn Lys Lys Leu Ile Pro Asn Asn Leu           
        115                 120                 125                       

gtc gaa aac tac ctg aca cca atg agt ctg gcc tat tgg ttc atg gac        432
Val Glu Asn Tyr Leu Thr Pro Met Ser Leu Ala Tyr Trp Phe Met Asp           
    130                 135                 140                           

gat ggc gga aaa tgg gac tac aac aag aac agc ctg aac aag agc atc        480
Asp Gly Gly Lys Trp Asp Tyr Asn Lys Asn Ser Leu Asn Lys Ser Ile           
145                 150                 155                 160           

gtg ctg aac acc cag tcc ttc aca ttt gag gaa gtc gag tat ctg ctg        528
Val Leu Asn Thr Gln Ser Phe Thr Phe Glu Glu Val Glu Tyr Leu Leu           
                165                 170                 175               

aag gga ctg agg aac aag ttc cag ctg aac tgc tac gtg aag att aac        576
Lys Gly Leu Arg Asn Lys Phe Gln Leu Asn Cys Tyr Val Lys Ile Asn           
            180                 185                 190                   

aag aac aag ccc atc atc tac atc gat tct atg agt tac ctg atc ttt        624
Lys Asn Lys Pro Ile Ile Tyr Ile Asp Ser Met Ser Tyr Leu Ile Phe           
        195                 200                 205                       

tat aat ctg att aag cca tac ctg atc ccc cag atg atg tat aaa ctg        672
Tyr Asn Leu Ile Lys Pro Tyr Leu Ile Pro Gln Met Met Tyr Lys Leu           
    210                 215                 220                           

cct aac aca atc agc tcc gag act ttc ctg aag                            705
Pro Asn Thr Ile Ser Ser Glu Thr Phe Leu Lys                               
225                 230                 235                               


<210>  36
<211>  235
<212>  PRT
<213>  Unknown

<220>
<223>  Synthetic Construct

<400>  36

Met Lys Asn Ile Lys Lys Asn Gln Val Ile Asn Leu Gly Pro Ile Ser 
1               5                   10                  15      


Lys Leu Leu Lys Glu Tyr Lys Ser Gln Leu Ile Glu Leu Asn Ile Glu 
            20                  25                  30          


Gln Phe Glu Ala Gly Ile Gly Leu Ile Leu Gly Asp Ala Tyr Ile Arg 
        35                  40                  45              


Ser Arg Asp Glu Gly Lys Thr Tyr Cys Met Gln Phe Glu Trp Lys Asn 
    50                  55                  60                  


Lys Ala Tyr Met Asp His Val Cys Leu Leu Tyr Asp Gln Trp Val Leu 
65                  70                  75                  80  


Ser Pro Pro His Lys Lys Glu Arg Val Asn His Leu Gly Asn Leu Val 
                85                  90                  95      


Ile Thr Trp Gly Ala Gln Thr Phe Lys His Gln Ala Phe Asn Lys Leu 
            100                 105                 110         


Ala Asn Leu Phe Ile Val Asn Asn Lys Lys Leu Ile Pro Asn Asn Leu 
        115                 120                 125             


Val Glu Asn Tyr Leu Thr Pro Met Ser Leu Ala Tyr Trp Phe Met Asp 
    130                 135                 140                 


Asp Gly Gly Lys Trp Asp Tyr Asn Lys Asn Ser Leu Asn Lys Ser Ile 
145                 150                 155                 160 


Val Leu Asn Thr Gln Ser Phe Thr Phe Glu Glu Val Glu Tyr Leu Leu 
                165                 170                 175     


Lys Gly Leu Arg Asn Lys Phe Gln Leu Asn Cys Tyr Val Lys Ile Asn 
            180                 185                 190         


Lys Asn Lys Pro Ile Ile Tyr Ile Asp Ser Met Ser Tyr Leu Ile Phe 
        195                 200                 205             


Tyr Asn Leu Ile Lys Pro Tyr Leu Ile Pro Gln Met Met Tyr Lys Leu 
    210                 215                 220                 


Pro Asn Thr Ile Ser Ser Glu Thr Phe Leu Lys 
225                 230                 235 


<210>  37
<211>  221
<212>  DNA
<213>  Homo sapiens

<400>  37
cgggtggcat ccctgtgacc cctccccagt gcctctcctg gccctggaag ttgccactcc       60

agtgcccacc agccttgtcc taataaaatt aagttgcatc attttgtctg actaggtgtc      120

cttctataat attatggggt ggaggggggt ggtatggagc aaggggcaag ttgggaagac      180

aacctgtagg gcctgcgggg tctattcggg aaccaagctg g                          221


<210>  38
<211>  491
<212>  DNA
<213>  Unknown

<220>
<223>  encephalomyocarditis virus

<400>  38
attttccacc atattgccgt cttttggcaa tgtgagggcc cggaaacctg gccctgtctt       60

cttgacgagc attcctaggg gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa      120

tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac      180

cctttgcagg cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg      240

tgtataagat acacctgcaa aggcggcaca accccagtgc cacgttgtga gttggatagt      300

tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac aaggggctga aggatgccca      360

gaaggtaccc cattgtatgg gatctgatct ggggcctcgg tgcacatgct ttacatgtgt      420

ttagtcgagg ttaaaaaacg tctaggcccc ccgaaccacg gggacgtggt tttcctttga      480

aaaacacgat c                                                           491


<210>  39
<211>  34
<212>  DNA
<213>  Bacteriophage P1

<400>  39
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210>  40
<211>  1650
<212>  DNA
<213>  Unknown

<220>
<223>  wild-type native firefly luciferase


<220>
<221>  CDS
<222>  (1)..(1650)

<400>  40
atg gaa gat gcc aaa aac att aag aag ggc cca gcg cca ttc tac cca         48
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro           
1               5                   10                  15                

ctc gaa gac ggg acc gcc ggc gag cag ctg cac aaa gcc atg aag cgc         96
Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg           
            20                  25                  30                    

tac gcc ctg gtg ccc ggc acc atc gcc ttt acc gac gca cat atc gag        144
Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu           
        35                  40                  45                        

gtg gac att acc tac gcc gag tac ttc gag atg agc gtt cgg ctg gca        192
Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala           
    50                  55                  60                            

gaa gct atg aag cgc tat ggg ctg aat aca aac cat cgg atc gtg gtg        240
Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val           
65                  70                  75                  80            

tgc agc gag aat agc ttg cag ttc ttc atg ccc gtg ttg ggt gcc ctg        288
Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu           
                85                  90                  95                

ttc atc ggt gtg gct gtg gcc cca gct aac gac atc tac aac gag cgc        336
Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg           
            100                 105                 110                   

gag ctg ctg aac agc atg ggc atc agc cag ccc acc gtc gta ttc gtg        384
Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val           
        115                 120                 125                       

agc aag aaa ggg ctg caa aag atc ctc aac gtg caa aag aag cta ccg        432
Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro           
    130                 135                 140                           

atc ata caa aag atc atc atc atg gat agc aag acc gac tac cag ggc        480
Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly           
145                 150                 155                 160           

ttc caa agc atg tac acc ttc gtg act tcc cat ttg cca ccc ggc ttc        528
Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe           
                165                 170                 175               

aac gag tac gac ttc gtg ccc gag agc ttc gac cgg gac aaa acc atc        576
Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile           
            180                 185                 190                   

gcc ctg atc atg aac agt agt ggc agt acc gga ttg ccc aag ggc gta        624
Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val           
        195                 200                 205                       

gcc cta ccg cac cgc acc gct tgt gtc cga ttc agt cat gcc cgc gac        672
Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp           
    210                 215                 220                           

ccc atc ttc ggc aac cag atc atc ccc gac acc gct atc ctc agc gtg        720
Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val           
225                 230                 235                 240           

gtg cca ttt cac cac ggc ttc ggc atg ttc acc acg ctg ggc tac ttg        768
Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu           
                245                 250                 255               

atc tgc ggc ttt cgg gtc gtg ctc atg tac cgc ttc gag gag gag cta        816
Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu           
            260                 265                 270                   

ttc ttg cgc agc ttg caa gac tat aag att caa tct gcc ctg ctg gtg        864
Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val           
        275                 280                 285                       

ccc aca cta ttt agc ttc ttc gct aag agc act ctc atc gac aag tac        912
Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr           
    290                 295                 300                           

gac cta agc aac ttg cac gag atc gcc agc ggc ggg gcg ccg ctc agc        960
Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser           
305                 310                 315                 320           

aag gag gta ggt gag gcc gtg gcc aaa cgc ttc cac cta cca ggc atc       1008
Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile           
                325                 330                 335               

cgc cag ggc tac ggc ctg aca gaa aca acc agc gcc att ctg atc acc       1056
Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr           
            340                 345                 350                   

ccc gaa ggg gac gac aag cct ggc gca gta ggc aag gtg gtg ccc ttc       1104
Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe           
        355                 360                 365                       

ttc gag gct aag gtg gtg gac ttg gac acc ggt aag aca ctg ggt gtg       1152
Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val           
    370                 375                 380                           

aac cag cgc ggc gag ctg tgc gtc cgt ggc ccc atg atc atg agc ggc       1200
Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly           
385                 390                 395                 400           

tac gtt aac aac ccc gag gct aca aac gct ctc atc gac aag gac ggc       1248
Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly           
                405                 410                 415               

tgg ctg cac agc ggc gac atc gcc tac tgg gac gag gac gag cac ttc       1296
Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe           
            420                 425                 430                   

ttc atc gtg gac cgg ctg aag agc ctg atc aaa tac aag ggc tac cag       1344
Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln           
        435                 440                 445                       

gta gcc cca gcc gaa ctg gag agc atc ctg ctg caa cac ccc aac atc       1392
Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile           
    450                 455                 460                           

ttc gac gcc ggg gtc gcc ggc ctg ccc gac gac gat gcc ggc gag ctg       1440
Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu           
465                 470                 475                 480           

tcc gcc gca gtc gtc gtg ctg gaa cac ggt aaa acc atg acc gag aag       1488
Ser Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys           
                485                 490                 495               

gag atc gtg gac tat gtg gcc agc cag gtt aca acc gcc aag aag ctg       1536
Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu           
            500                 505                 510                   

cgc ggt ggt gtt gtg ttc gtg gac gag gtg cct aaa gga ctg acc ggc       1584
Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly           
        515                 520                 525                       

aag ttg gac gcc cgc aag atc cgc gag att ctc att aag gcc aag aag       1632
Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys           
    530                 535                 540                           

ggc ggc aag atc gcc gtg                                               1650
Gly Gly Lys Ile Ala Val                                                   
545                 550                                                   


<210>  41
<211>  550
<212>  PRT
<213>  Unknown

<220>
<223>  Synthetic Construct

<400>  41

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Ser Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val 
545                 550 


<210>  42
<211>  239
<212>  DNA
<213>  Simian virus 40

<400>  42
ggccgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa       60

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca      120

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc      180

agggggagat gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtaaaatc       239


<210>  43
<211>  1650
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  firefly luciferase


<220>
<221>  CDS
<222>  (1)..(1650)

<400>  43
atg gag gac gcc aag aac atc aag aag ggc ccc gcc ccc ttc tac ccc         48
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro           
1               5                   10                  15                

ctg gag gac ggc acc gcc gga gag cag ctg cac aag gcc atg aag aga         96
Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg           
            20                  25                  30                    

tac gcc ctg gtg ccc ggc acc atc gcc ttc acc gac gcc cac atc gag        144
Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu           
        35                  40                  45                        

gtg gac atc acc tac gcc gag tac ttc gag atg agc gtg aga ctg gcc        192
Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala           
    50                  55                  60                            

gag gcc atg aag aga tac ggc ctg aac acc aac cac aga atc gtg gtg        240
Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val           
65                  70                  75                  80            

tgc agc gag aac agc ctg cag ttc ttc atg ccc gtg ctg gga gcc ctg        288
Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu           
                85                  90                  95                

ttc atc ggc gtg gcc gtg gcc ccc gcc aac gac atc tac aac gag aga        336
Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg           
            100                 105                 110                   

gag ctg ctg aac agc atg ggc atc agc cag ccc acc gtg gtg ttc gtg        384
Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val           
        115                 120                 125                       

agc aag aag ggc ctg cag aag atc ctg aac gtg cag aag aag ctg ccc        432
Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro           
    130                 135                 140                           

atc atc cag aag atc atc atc atg gac agc aag acc gac tac cag ggc        480
Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly           
145                 150                 155                 160           

ttc cag agc atg tat acc ttc gtg acc agc cac ctg ccc ccc ggc ttc        528
Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe           
                165                 170                 175               

aac gag tac gac ttc gtg ccc gag agc ttc gac aga gac aag acc atc        576
Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile           
            180                 185                 190                   

gcc ctg atc atg aac agc agc ggc agc acc ggc ctg ccc aag ggc gtg        624
Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val           
        195                 200                 205                       

gcc ctg ccc cac aga acc gcc tgc gtg aga ttc agc cac gcc aga gac        672
Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp           
    210                 215                 220                           

ccc atc ttc ggc aac cag atc atc ccc gac acc gcc atc ctg agc gtg        720
Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val           
225                 230                 235                 240           

gtg ccc ttc cac cac ggc ttc ggc atg ttc acc acc ctg ggc tac ctg        768
Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu           
                245                 250                 255               

atc tgc ggc ttc aga gtg gtg ctg atg tat aga ttc gag gag gag ctg        816
Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu           
            260                 265                 270                   

ttc ctg aga agc ctg cag gac tac aag atc cag agc gcc ctg ctg gtg        864
Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val           
        275                 280                 285                       

ccc acc ctg ttc agc ttc ttc gcc aag agc acc ctg atc gac aag tac        912
Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr           
    290                 295                 300                           

gac ctg agc aac ctg cac gag atc gcc agc ggc gga gcc ccc ctg agc        960
Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser           
305                 310                 315                 320           

aag gag gtg ggc gag gcc gtg gcc aag aga ttc cac ctg ccc ggc atc       1008
Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile           
                325                 330                 335               

aga cag ggc tac ggc ctg acc gag acc acc agc gcc atc ctg atc acc       1056
Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr           
            340                 345                 350                   

ccc gag ggc gac gac aag ccc gga gcc gtg ggc aag gtg gtg ccc ttc       1104
Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe           
        355                 360                 365                       

ttc gag gcc aag gtg gtg gac ctg gac acc ggc aag acc ctg ggc gtg       1152
Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val           
    370                 375                 380                           

aac cag aga ggc gag ctg tgc gtg aga ggc ccc atg att atg tcc ggc       1200
Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly           
385                 390                 395                 400           

tac gtg aac aac ccc gag gcc acc aac gcc ctg atc gac aag gac ggc       1248
Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly           
                405                 410                 415               

tgg ctg cac agc ggc gac atc gcc tac tgg gac gag gac gag cac ttc       1296
Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe           
            420                 425                 430                   

ttc atc gtg gac aga ctg aag agc ctg atc aag tac aag ggc tac cag       1344
Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln           
        435                 440                 445                       

gtg gcc ccc gcc gag ctg gag agc atc ctg ctg cag cac ccc aac atc       1392
Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile           
    450                 455                 460                           

ttc gac gcc gga gtg gcc gga ctg ccc gac gac gac gcc gga gag ctg       1440
Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu           
465                 470                 475                 480           

ccc gcc gcc gtg gtg gtg ctg gag cac ggc aag acc atg acc gag aag       1488
Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys           
                485                 490                 495               

gag atc gtg gac tac gtg gcc agc cag gtg aca acc gcc aag aag ctg       1536
Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu           
            500                 505                 510                   

aga ggc ggc gtg gtg ttc gtg gac gag gtg ccc aag ggc ctg acc ggc       1584
Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly           
        515                 520                 525                       

aag ctg gac gcc aga aag atc aga gag atc ctg atc aag gcc aag aag       1632
Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys           
    530                 535                 540                           

ggc ggc aag atc gcc gtg                                               1650
Gly Gly Lys Ile Ala Val                                                   
545                 550                                                   


<210>  44
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val 
545                 550 


<210>  45
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from c-Myc NLS, zinc finger homeodomain and 
       FKBP


<220>
<221>  CDS
<222>  (1)..(411)

<400>  45
atg gac tat cct gct gcc aag agg gtc aag ttg gac tct aga gaa cgc         48
Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg           
1               5                   10                  15                

cca tat gct tgc cct gtc gag tcc tgc gat cgc cgc ttt tct cgc tcg         96
Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser           
            20                  25                  30                    

gat gag ctt acc cgc cat atc cgc atc cac aca ggc cag aag ccc ttc        144
Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe           
        35                  40                  45                        

cag tgt cga atc tgc atg cgt aac ttc agt cgt agt gac cac ctt acc        192
Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr           
    50                  55                  60                            

acc cac atc cgc acc cac aca ggc ggc ggc cgc agg agg aag aaa cgc        240
Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg           
65                  70                  75                  80            

acc agc ata gag acc aac atc cgt gtg gcc tta gag aag agt ttc ttg        288
Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu           
                85                  90                  95                

gag aat caa aag cct acc tcg gaa gag atc act atg att gct gat cag        336
Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln           
            100                 105                 110                   

ctc aat atg gaa aaa gag gtg att cgt gtt tgg ttc tgt aac cgc cgc        384
Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg           
        115                 120                 125                       

cag aaa gaa aaa aga atc aac act aga                                    411
Gln Lys Glu Lys Arg Ile Asn Thr Arg                                       
    130                 135                                               


<210>  46
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Arg 
    130                 135         


<210>  47
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from SV40 and FRAP


<220>
<221>  CDS
<222>  (1)..(897)

<400>  47
atg ccc aag aag aag aga aag gtg atc ctg tgg cac gag atg tgg cac         48
Met Pro Lys Lys Lys Arg Lys Val Ile Leu Trp His Glu Met Trp His           
1               5                   10                  15                

gag ggc ctg gag gag gcc agc aga ctg tac ttc ggc gag aga aac gtg         96
Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val           
            20                  25                  30                    

aag ggc atg ttc gag gtg ctg gag ccc ctg cac gcc atg atg gag aga        144
Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg           
        35                  40                  45                        

ggc ccc cag acc ctg aag gag acc agc ttc aac cag gct tac ggc aga        192
Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg           
    50                  55                  60                            

gac ctg atg gag gcc cag gag tgg tgc aga aag tac atg aag tcc ggc        240
Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly           
65                  70                  75                  80            

aac gtg aag gac ctg ctg cag gct tgg gac ctg tac tac cac gtg ttc        288
Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe           
                85                  90                  95                

aga aga atc agc aag cag ctg ccc cag ctg act agt gac gag ttc ccc        336
Arg Arg Ile Ser Lys Gln Leu Pro Gln Leu Thr Ser Asp Glu Phe Pro           
            100                 105                 110                   

acc atg gtg ttc ccc agc ggc cag atc agc cag gcc agc gcc ctg gcc        384
Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala           
        115                 120                 125                       

ccc gcc ccc ccc cag gtg ctg ccc cag gcc ccc gcc ccc gcc ccc gcc        432
Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala           
    130                 135                 140                           

ccc gcc atg gtg agc gcc ctg gcc cag gcc ccc gcc ccc gtg ccc gtg        480
Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val           
145                 150                 155                 160           

ctg gcc ccc ggc ccc ccc cag gcc gtg gcc ccc ccc gcc ccc aag ccc        528
Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro           
                165                 170                 175               

acc cag gcc gga gag ggc acc ctg agc gag gcc ctg ctg cag ctg cag        576
Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln           
            180                 185                 190                   

ttc gac gac gag gac ctg gga gcc ctg ctg ggc aac agc acc gac ccc        624
Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro           
        195                 200                 205                       

gcc gtg ttc acc gac ctg gcc agc gtg gac aac agc gag ttc cag cag        672
Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln           
    210                 215                 220                           

ctg ctg aac cag ggc atc ccc gtg gcc ccc cac acc acc gag ccc atg        720
Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met           
225                 230                 235                 240           

ctg atg gag tac ccc gag gcc atc acc aga ctg gtc aca gga gcc cag        768
Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln           
                245                 250                 255               

aga ccc ccc gac ccc gcc ccc gcc ccc ctg gga gcc ccc ggc ctg ccc        816
Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro           
            260                 265                 270                   

aac ggc ctg ctc agc ggc gac gag gac ttc agc agc atc gcc gac atg        864
Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met           
        275                 280                 285                       

gac ttc agc gcc ctg ctg agc cag atc agc agc                            897
Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser                               
    290                 295                                               


<210>  48
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Met Pro Lys Lys Lys Arg Lys Val Ile Leu Trp His Glu Met Trp His 
1               5                   10                  15      


Glu Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val 
            20                  25                  30          


Lys Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg 
        35                  40                  45              


Gly Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg 
    50                  55                  60                  


Asp Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly 
65                  70                  75                  80  


Asn Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe 
                85                  90                  95      


Arg Arg Ile Ser Lys Gln Leu Pro Gln Leu Thr Ser Asp Glu Phe Pro 
            100                 105                 110         


Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala 
        115                 120                 125             


Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala 
    130                 135                 140                 


Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro 
                165                 170                 175     


Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln 
            180                 185                 190         


Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro 
        195                 200                 205             


Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln 
    210                 215                 220                 


Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met 
225                 230                 235                 240 


Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln 
                245                 250                 255     


Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro 
            260                 265                 270         


Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met 
        275                 280                 285             


Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser 
    290                 295                 


<210>  49
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from ZFHD


<220>
<221>  CDS
<222>  (1)..(366)

<400>  49
atg gag aga ccc tac gcc tgc ccc gtg gag agc tgc gac aga aga ttc         48
Met Glu Arg Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe           
1               5                   10                  15                

agc aga agc gac gag ctg acc aga cac atc aga atc cac acc ggc cag         96
Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln           
            20                  25                  30                    

aag ccc ttc cag tgc aga atc tgc atg aga aac ttc agc aga agc gac        144
Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp           
        35                  40                  45                        

cac ctg acc acc cac atc aga acc cac aca ggc ggc ggc aga aga aga        192
His Leu Thr Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg           
    50                  55                  60                            

aag aag aga acc agc atc gag acc aac atc aga gtg gcc ctg gag aaa        240
Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys           
65                  70                  75                  80            

agc ttc ctg gag aac cag aag ccc acc agc gag gag atc acc atg atc        288
Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile           
                85                  90                  95                

gcc gac cag ctg aac atg gag aag gag gtg atc aga gtg tgg ttc tgc        336
Ala Asp Gln Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys           
            100                 105                 110                   

aac aga aga cag aag gag aag aga atc aac                                366
Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn                                   
        115                 120                                           


<210>  50
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Met Glu Arg Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe 
1               5                   10                  15      


Ser Arg Ser Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln 
            20                  25                  30          


Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp 
        35                  40                  45              


His Leu Thr Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg 
    50                  55                  60                  


Lys Lys Arg Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys 
65                  70                  75                  80  


Ser Phe Leu Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile 
                85                  90                  95      


Ala Asp Gln Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys 
            100                 105                 110         


Asn Arg Arg Gln Lys Glu Lys Arg Ile Asn 
        115                 120         


<210>  51
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from SV40 and ZFHD


<220>
<221>  CDS
<222>  (1)..(387)

<400>  51
atg ccc aag aag aag aga aag gtg gag aga ccc tac gcc tgc ccc gtg         48
Met Pro Lys Lys Lys Arg Lys Val Glu Arg Pro Tyr Ala Cys Pro Val           
1               5                   10                  15                

gag agc tgc gac aga aga ttc agc aga agc gac gag ctg acc aga cac         96
Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg His           
            20                  25                  30                    

atc aga atc cac acc ggc cag aag ccc ttc cag tgc aga atc tgc atg        144
Ile Arg Ile His Thr Gly Gln Lys Pro Phe Gln Cys Arg Ile Cys Met           
        35                  40                  45                        

aga aac ttc agc aga agc gac cac ctg acc acc cac atc aga acc cac        192
Arg Asn Phe Ser Arg Ser Asp His Leu Thr Thr His Ile Arg Thr His           
    50                  55                  60                            

aca ggc ggc ggc aga aga aga aag aag aga acc agc atc gag acc aac        240
Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn           
65                  70                  75                  80            

atc aga gtg gcc ctg gag aaa agc ttc ctg gag aac cag aag ccc acc        288
Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr           
                85                  90                  95                

agc gag gag atc acc atg atc gcc gac cag ctg aac atg gag aag gag        336
Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys Glu           
            100                 105                 110                   

gtg atc aga gtg tgg ttc tgc aac aga aga cag aag gag aag aga atc        384
Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile           
        115                 120                 125                       

aac                                                                    387
Asn                                                                       
                                                                          


<210>  52
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Pro Lys Lys Lys Arg Lys Val Glu Arg Pro Tyr Ala Cys Pro Val 
1               5                   10                  15      


Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser Asp Glu Leu Thr Arg His 
            20                  25                  30          


Ile Arg Ile His Thr Gly Gln Lys Pro Phe Gln Cys Arg Ile Cys Met 
        35                  40                  45              


Arg Asn Phe Ser Arg Ser Asp His Leu Thr Thr His Ile Arg Thr His 
    50                  55                  60                  


Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg Thr Ser Ile Glu Thr Asn 
65                  70                  75                  80  


Ile Arg Val Ala Leu Glu Lys Ser Phe Leu Glu Asn Gln Lys Pro Thr 
                85                  90                  95      


Ser Glu Glu Ile Thr Met Ile Ala Asp Gln Leu Asn Met Glu Lys Glu 
            100                 105                 110         


Val Ile Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Glu Lys Arg Ile 
        115                 120                 125             


Asn 
    


<210>  53
<211>  324
<212>  DNA
<213>  Unknown

<220>
<223>  wild type FKBP


<220>
<221>  CDS
<222>  (1)..(324)

<400>  53
atg gga gtg cag gtg gaa acc atc tcc cca gga gac ggg cgc acc ttc         48
Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe           
1               5                   10                  15                

ccc aag cgc ggc cag acc tgc gtg gtg cac tac acc ggg atg ctt gaa         96
Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu           
            20                  25                  30                    

gat gga aag aaa ttt gat tcc tcc cgg gac aga aac aag ccc ttt aag        144
Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys           
        35                  40                  45                        

ttt atg cta ggc aag cag gag gtg atc cga ggc tgg gaa gaa ggg gtt        192
Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val           
    50                  55                  60                            

gcc cag atg agt gtg ggt cag aga gcc aaa ctg act ata tct cca gat        240
Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp           
65                  70                  75                  80            

tat gcc tat ggt gcc act ggg cac cca ggc atc atc cca cca cat gcc        288
Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala           
                85                  90                  95                

act ctc gtc ttc gat gtg gag ctt cta aaa ctg gaa                        324
Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu                           
            100                 105                                       


<210>  54
<211>  108
<212>  PRT
<213>  Unknown

<220>
<223>  Synthetic Construct

<400>  54

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  55
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from FKBP

<400>  55
ggcgtgcagg tggagaccat cagccccggc gacggcagaa ccttccccaa gagaggccag       60

acctgcgtgg tgcactacac cggaatgctg gaggacggca agaagttcga cagcagcaga      120

gacagaaaca agcccttcaa gttcatgctg ggcaagcagg aggtgatcag aggctgggag      180

gagggcgtgg cccagatgag cgtgggccag agagccaagc tgaccatcag ccccgactac      240

gcctacggag ccaccggcca ccccggcatc atcccccccc acgccaccct ggtgttcgac      300

gtggagctgc tgaagctgga g                                                321


<210>  56
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from FKBP

<400>  56
ggcgtgcagg tcgagaccat cagccccggc gacggccgca cctttcccaa gagaggccag       60

acttgcgtgg tccactacac cggcatgctg gaggacggca agaagttcga cagcagccgc      120

gaccgcaaca agcccttcaa gttcatgctg ggcaaacagg aagtgatccg cggctgggag      180

gaaggcgtgg ctcagatgag cgtggggcag cgggccaagc tgaccatcag ccccgactat      240

gcctacggcg ccaccggcca ccccggcatc atcccccccc acgccaccct ggtgttcgac      300

gtggagctgc tgaagctgga gtga                                             324


<210>  57
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from FKBP

<400>  57
ggcgttcagg tggaaaccat cagtccaggg gatggccgaa cttttccaaa gagagggcag       60

acttgcgtcg tgcattatac tggtatgctg gaggatggga aaaagttcga ctcttccaga      120

gatcggaaca aaccattcaa attcatgctc gggaaacagg aagttatccg cggatgggag      180

gagggcgtgg cccagatgtc cgtgggccag cgcgccaagc taaccatctc cccagactac      240

gcctacggag ccaccggaca ccccggtatc atacccccac acgccaccct tgtgtttgac      300

gtggaactgc ttaagctaga g                                                321


<210>  58
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified construct from FKBP

<400>  58
ggcgtacaag tagagactat aagtcctggt gatggaagga cttttccaaa aagaggacaa       60

acatgtgtag ttcattatac gggtatgttg gaggacggca aaaagttcga cagtagtaga      120

gatcgtaata aaccattcaa attcatgttg ggtaaacaag aagtcattag gggatgggag      180

gagggagtcg ctcaaatgtc ggttggacaa cgtgctaagt taacaatcag ccctgactac      240

gcatacggag ctacaggaca tcctggtatt atacctcccc acgctacctt ggtgtttgac      300

gtcgaactgc tgaagttaga g                                                321


<210>  59
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified FokI enzyme


<220>
<221>  CDS
<222>  (1)..(1449)

<220>
<221>  misc_feature
<222>  (1)..(84)
<223>  zinc finger N1

<220>
<221>  misc_feature
<222>  (85)..(168)
<223>  zinc finger N2

<220>
<221>  misc_feature
<222>  (169)..(252)
<223>  zinc finger N3

<220>
<221>  misc_feature
<222>  (253)..(336)
<223>  zinc finger N4

<220>
<221>  misc_feature
<222>  (337)..(420)
<223>  zinc finger N5

<220>
<221>  misc_feature
<222>  (421)..(504)
<223>  zinc finger N6

<220>
<221>  misc_feature
<222>  (505)..(588)
<223>  zinc finger N7

<220>
<221>  misc_feature
<222>  (589)..(672)
<223>  zinc finger N8

<220>
<221>  misc_feature
<222>  (673)..(756)
<223>  zinc finger N9

<220>
<221>  misc_feature
<222>  (757)..(840)
<223>  zinc finger N10

<220>
<221>  misc_feature
<222>  (841)..(855)
<223>  5 amino acid linker

<220>
<221>  misc_feature
<222>  (856)..(1443)
<223>  FokI catalytic domain

<400>  59
atg ggc gag aag ccc tac aag tgc cct gag tgc ggc aag agc ttc agc         48
Met Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser           
1               5                   10                  15                

cag aga aga agc ctg ggc cac cac cag cgt acg cac ccc ggc gag aaa         96
Gln Arg Arg Ser Leu Gly His His Gln Arg Thr His Pro Gly Glu Lys           
            20                  25                  30                    

cct tat aag tgt ccc gaa tgt ggc aag tcc ttc agc aag aag aac gac        144
Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Lys Lys Asn Asp           
        35                  40                  45                        

ctg acc cgg cac cag cgg aca cac ccc ggg gaa aag cca tac aaa tgt        192
Leu Thr Arg His Gln Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys           
    50                  55                  60                            

cca gag tgt ggg aag tct ttc tcc agc cgg cgg acc tgc aga gcc cat        240
Pro Glu Cys Gly Lys Ser Phe Ser Ser Arg Arg Thr Cys Arg Ala His           
65                  70                  75                  80            

cag aga aca cat acc ggg gag aag cct ttc cag tgc cgg atc tgc atg        288
Gln Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met           
                85                  90                  95                

aga aac ttc agc gtg cgg cac aac ctg acc aga cac ctg agg acc cat        336
Arg Asn Phe Ser Val Arg His Asn Leu Thr Arg His Leu Arg Thr His           
            100                 105                 110                   

acc ggc gaa aaa ccc ttt cag tgc aga atc tgt atg cgg aac ttc tcc        384
Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser           
        115                 120                 125                       

gac cgg acc agc ctg gcc cgg cat ctg aga act cat cct ggg gaa aag        432
Asp Arg Thr Ser Leu Ala Arg His Leu Arg Thr His Pro Gly Glu Lys           
    130                 135                 140                           

ccc tat aag tgt cca gaa tgc ggg aaa tcc ttt agc gac agc ggc aac        480
Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Ser Gly Asn           
145                 150                 155                 160           

ctg cgg gtg cac cag agg act cat cca ggc gag aaa ccc tac aaa tgc        528
Leu Arg Val His Gln Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys           
                165                 170                 175               

ccc gaa tgc gga aag tca ttc tcc cac acc ggc cat ctg ctc gag cat        576
Pro Glu Cys Gly Lys Ser Phe Ser His Thr Gly His Leu Leu Glu His           
            180                 185                 190                   

cag cgg acc cac act ggg gag aaa cca ttt cag tgt cgc atc tgt atg        624
Gln Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met           
        195                 200                 205                       

agg aat ttc agc acc aac cag gcc ctg ggc gtg cac ctg aga aca cac        672
Arg Asn Phe Ser Thr Asn Gln Ala Leu Gly Val His Leu Arg Thr His           
    210                 215                 220                           

cca ggc gag aag cct tac aag tgt cca gag tgc gga aag tca ttt tcc        720
Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser           
225                 230                 235                 240           

gtg cgc cac aat ctg aca cgg cat cag cgc acc cat ccc ggc gag aag        768
Val Arg His Asn Leu Thr Arg His Gln Arg Thr His Pro Gly Glu Lys           
                245                 250                 255               

cct tac aaa tgc ccc gag tgt ggc aaa tct ttc agt gac cgg acc tct        816
Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Arg Thr Ser           
            260                 265                 270                   

ctg gcc aga cat cag agg aca cac ggc act agt ggc aag cag ctg gtg        864
Leu Ala Arg His Gln Arg Thr His Gly Thr Ser Gly Lys Gln Leu Val           
        275                 280                 285                       

aaa agc gag ctg gaa gag aag aag tcc gag ctg cgg cac aag ctg aaa        912
Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys           
    290                 295                 300                           

tac gtg ccc cac gag tac atc gag ctg atc gag atc gcc cgg aac ccc        960
Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro           
305                 310                 315                 320           

acc cag gac aga atc ctg gaa atg aag gtc atg gaa ttt ttc atg aag       1008
Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys           
                325                 330                 335               

gtg tac ggc tac cgg ggc gag cac ctg ggc ggc agc aga aaa ccc gac       1056
Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp           
            340                 345                 350                   

ggc gcc atc tac acc gtg ggc agc ccc atc gac tac ggc gtg atc gtg       1104
Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val           
        355                 360                 365                       

gac acc aag gcc tac agc ggc ggc tac aac ctg ccc atc gga cag gcc       1152
Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala           
    370                 375                 380                           

gac gag atg cag aga tac gtg gaa gag aac cag acc cgg aac aag cac       1200
Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His           
385                 390                 395                 400           

atc aac ccc aac gag tgg tgg aag gtg tac ccc agc agc gtg acc gag       1248
Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu           
                405                 410                 415               

ttc aag ttc ctg ttc gtg tcc ggc cac ttc aag ggc aac tac aag gcc       1296
Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala           
            420                 425                 430                   

cag ctg acc cgg ctg aac cac atc acc aac tgc aac ggc gct gtg ctg       1344
Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu           
        435                 440                 445                       

agc gtg gaa gaa ctg ctg atc ggc ggc gag atg atc aag gcc ggc acc       1392
Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr           
    450                 455                 460                           

ctg acc ctg gaa gaa gtg cgg cgg aag ttc aac aac ggc gag atc aac       1440
Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn           
465                 470                 475                 480           

ttc tga tag                                                           1449
Phe                                                                       
                                                                          


<210>  60
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Met Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser 
1               5                   10                  15      


Gln Arg Arg Ser Leu Gly His His Gln Arg Thr His Pro Gly Glu Lys 
            20                  25                  30          


Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Lys Lys Asn Asp 
        35                  40                  45              


Leu Thr Arg His Gln Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys 
    50                  55                  60                  


Pro Glu Cys Gly Lys Ser Phe Ser Ser Arg Arg Thr Cys Arg Ala His 
65                  70                  75                  80  


Gln Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met 
                85                  90                  95      


Arg Asn Phe Ser Val Arg His Asn Leu Thr Arg His Leu Arg Thr His 
            100                 105                 110         


Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
        115                 120                 125             


Asp Arg Thr Ser Leu Ala Arg His Leu Arg Thr His Pro Gly Glu Lys 
    130                 135                 140                 


Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Ser Gly Asn 
145                 150                 155                 160 


Leu Arg Val His Gln Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys 
                165                 170                 175     


Pro Glu Cys Gly Lys Ser Phe Ser His Thr Gly His Leu Leu Glu His 
            180                 185                 190         


Gln Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met 
        195                 200                 205             


Arg Asn Phe Ser Thr Asn Gln Ala Leu Gly Val His Leu Arg Thr His 
    210                 215                 220                 


Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser 
225                 230                 235                 240 


Val Arg His Asn Leu Thr Arg His Gln Arg Thr His Pro Gly Glu Lys 
                245                 250                 255     


Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Arg Thr Ser 
            260                 265                 270         


Leu Ala Arg His Gln Arg Thr His Gly Thr Ser Gly Lys Gln Leu Val 
        275                 280                 285             


Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys 
    290                 295                 300                 


Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Pro 
305                 310                 315                 320 


Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys 
                325                 330                 335     


Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly Ser Arg Lys Pro Asp 
            340                 345                 350         


Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val 
        355                 360                 365             


Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala 
    370                 375                 380                 


Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His 
385                 390                 395                 400 


Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu 
                405                 410                 415     


Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala 
            420                 425                 430         


Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu 
        435                 440                 445             


Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr 
    450                 455                 460                 


Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn 
465                 470                 475                 480 


Phe 
    


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  61

Gln Arg Ala Asn Leu Arg Ala 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  62

Gln Arg Ser Asn Leu Lys Val 
1               5           


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  63

Asp Arg Ser Asn Arg Lys Thr 
1               5           


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  64

Asp Ser Gly Asn Leu Arg Val 
1               5           


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  65

Gly Ala Ser Ala Leu Arg Gln 
1               5           


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  66

Gly Ala Ser Ala Leu Arg Ser 
1               5           


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  67

Gly Gly Thr Ala Leu Arg Met 
1               5           


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  68

Gly Gly Thr Ala Leu Val Met 
1               5           


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  69

Gly His Thr Ala Leu Ala Leu 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  70

Gly His Thr Ala Leu Arg His 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  71

Gly His Thr Ala Leu Arg Asn 
1               5           


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  72

Gly Pro Thr Ala Leu Val Asn 
1               5           


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  73

His Arg Thr Asn Leu Ile Ala 
1               5           


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  74

Arg Lys Asp Asn Leu Lys Asn 
1               5           


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  75

Arg Ser Ala Asn Leu Ser Val 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  76

Arg Ser Asp Asn Leu Ser Val 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  77

Arg Ser Asp Asn Leu Thr Gln 
1               5           


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  78

Thr Ser Ser Asn Arg Lys Thr 
1               5           


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  79

Thr Thr Gly Asn Leu Thr Val 
1               5           


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  80

Val Ser Ser Asn Leu Asn Val 
1               5           


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  81

Gln Asn Ala Thr Arg Ile Asn 
1               5           


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  82

Ser Pro Ala Asp Leu Thr Arg 
1               5           


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  83

Asp Lys Lys Asp Leu Thr Arg 
1               5           


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  84

Ala Ser Ala Asp Leu Thr Arg 
1               5           


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  85

Lys Gly Asn Asp Leu Thr Arg 
1               5           


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  86

Lys Asn Asn Asp Leu Thr Arg 
1               5           


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  87

Lys Arg Ile Asp Leu Gln Arg 
1               5           


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  88

Gln Asn Ala Thr Arg Lys Arg 
1               5           


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  89

Gln Ser Gly Asp Leu Thr Arg 
1               5           


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  90

Arg Lys His Asp Leu Asn Met 
1               5           


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  91

Arg Asn Ile Thr Leu Val Arg 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  92

Arg Arg Gln Thr Leu Arg Gln 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  93

Arg Ser His Asp Leu Thr Val 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  94

Arg Ser Gln Thr Leu Ala Gln 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  95

Arg Thr Asp Thr Leu Arg Asp 
1               5           


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  96

Ala Arg Ser Thr Arg Thr Asn 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  97

His Ala Ser Thr Arg His Cys 
1               5           


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  98

Thr His Leu Asp Leu Ile Arg 
1               5           


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  99

Lys Asn Trp Lys Leu Gln Ala 
1               5           


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  100

Gln Leu Ala His Leu Arg Ala 
1               5           


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  101

Gln Ser Ser His Leu Thr Thr 
1               5           


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  102

Arg Ser Ala Asn Leu Ala Arg 
1               5           


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  103

Glu Arg Ser His Leu Arg Glu 
1               5           


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  104

Asp Ser Ala His Leu Thr Arg 
1               5           


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  105

Gln Ser Ala His Arg Thr Lys 
1               5           


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  106

Arg Gly Asn His Leu Val Val 
1               5           


<210>  107
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  107

Arg Met Ala His Leu His Ala 
1               5           


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  108

Arg Asn Glu His Leu Lys Val 
1               5           


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  109

Arg Pro His His Leu Asp Ala 
1               5           


<210>  110
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  110

Arg Arg Ala His Leu Leu Asn 
1               5           


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  111

Arg Arg Ala His Leu Leu Ser 
1               5           


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  112

Arg Arg Ala His Leu Arg Gln 
1               5           


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  113

Arg Arg Thr His Leu Arg Val 
1               5           


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  114

Arg Ser Asp His Leu Lys Thr 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  115

Arg Ser Asp His Leu Ser Ala 
1               5           


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  116

Arg Ser Asp His Leu Ser Gln 
1               5           


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  117

Arg Ser Asp His Leu Thr Asn 
1               5           


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  118

Arg Ser Asp His Leu Thr Gln 
1               5           


<210>  119
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  119

Arg Ser Ser His Leu Lys Met 
1               5           


<210>  120
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  120

His Arg Thr Thr Leu Thr Asn 
1               5           


<210>  121
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  121

Gln Ser Ala His Leu Ser Thr 
1               5           


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  122

Gln Lys Ser Ser Leu Ile Ala 
1               5           


<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  123

Arg Arg Asp Glu Leu Asn Val 
1               5           


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  124

Arg Ser Asp Ser Leu Ser Val 
1               5           


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  125

His Lys Asn Ala Leu Gln Asn 
1               5           


<210>  126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  126

Asp Arg Ala Asn Leu Ser Thr 
1               5           


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  127

Gln Lys Ser Asn Leu Ile Ile 
1               5           


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  128

Gln Ser Gly Asn Leu Thr Glu 
1               5           


<210>  129
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  129

Gln Ser Ser Asn Leu Thr Val 
1               5           


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  130

Ser Lys Lys Ala Leu Thr Glu 
1               5           


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  131

Asp Ser Ala Asn Arg Thr Lys 
1               5           


<210>  132
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  132

Arg Ala Asp Asn Leu Thr Glu 
1               5           


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  133

Arg Ser Asp Asn Leu Arg Glu 
1               5           


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  134

Arg Ser Asp Asn Leu Ser Glu 
1               5           


<210>  135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  135

Arg Thr Asp Tyr Leu Val Asp 
1               5           


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  136

Asp Arg Ser Asn Arg Ile Lys 
1               5           


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  137

Thr Ser Gly Asn Leu Thr Glu 
1               5           


<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  138

Asp Arg Ser Asp Leu Ser Arg 
1               5           


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  139

Asn Arg Thr Asp Leu Ile Arg 
1               5           


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  140

Gln Asn Ser Thr Arg Ile Gly 
1               5           


<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  141

Thr Ser His Ser Leu Thr Glu 
1               5           


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  142

Ser Lys Lys His Leu Ala Glu 
1               5           


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  143

Asp Ser Ser Ser Leu Thr Arg 
1               5           


<210>  144
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  144

Asp Tyr Asp Val Arg Lys Arg 
1               5           


<210>  145
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  145

Arg Asn Asp Thr Leu Thr Glu 
1               5           


<210>  146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  146

Arg Ser Asp Thr Leu Ser Glu 
1               5           


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  147

Thr Lys Asn Ser Leu Thr Glu 
1               5           


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  148

Gln Ser Gly His Leu Thr Glu 
1               5           


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  149

Gln Ser Ser His Leu Asn Val 
1               5           


<210>  150
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  150

Gln Ser Thr His Leu Thr Gln 
1               5           


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  151

His Thr Gly His Leu Leu Glu 
1               5           


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  152

Arg Ser Asp Asn Leu Thr Glu 
1               5           


<210>  153
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  153

Arg Ser Asp Lys Leu Thr Glu 
1               5           


<210>  154
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  154

Arg Ser Gln Thr Arg Lys Thr 
1               5           


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  155

Ser Arg Arg Thr Cys Arg Ala 
1               5           


<210>  156
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  156

Asp Ser Ser Ser Arg Thr Lys 
1               5           


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  157

Gln Asn Ser Thr Leu Thr Glu 
1               5           


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  158

Ala Ser Asp Asp Leu Thr Gln 
1               5           


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  159

His Asn Tyr Ala Arg Asp Cys 
1               5           


<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  160

Arg Asn Asp Ala Leu Thr Glu 
1               5           


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  161

Arg Ser Asp Ala Leu Arg Glu 
1               5           


<210>  162
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  162

Arg Ser Asp Ala Leu Ser Ala 
1               5           


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  163

Arg Ser Asp Ala Leu Ser Asn 
1               5           


<210>  164
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  164

Arg Ser Asp Thr Leu Ser Glu 
1               5           


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  165

Thr Thr Gly Ala Leu Thr Glu 
1               5           


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  166

His Lys Pro Asn Leu His Arg 
1               5           


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  167

His Arg Pro Asn Leu Thr Arg 
1               5           


<210>  168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  168

Leu Gly Glu Asn Leu Arg Arg 
1               5           


<210>  169
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  169

Gln Ala Ser Asn Leu Ala Arg 
1               5           


<210>  170
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  170

Gln Ala Ser Asn Leu Leu Arg 
1               5           


<210>  171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  171

Gln Ala Ser Asn Leu Thr Arg 
1               5           


<210>  172
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  172

Gln Asp Gly Asn Leu Gly Arg 
1               5           


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  173

Gln Asp Gly Asn Leu Thr Arg 
1               5           


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  174

Gln Gly Ser Asn Leu Ala Arg 
1               5           


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  175

Gln His Pro Asn Leu Thr Arg 
1               5           


<210>  176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  176

Gln Lys Gly Asn Leu Leu Arg 
1               5           


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  177

Gln Lys Ser Asn Leu Ile Arg 
1               5           


<210>  178
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  178

Gln Leu Ser Asn Leu Thr Arg 
1               5           


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  179

Gln Gln Ser Asn Leu Ser Arg 
1               5           


<210>  180
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  180

Gln Gln Thr Asn Leu Thr Arg 
1               5           


<210>  181
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  181

Gln Arg Asn Asn Leu Gly Arg 
1               5           


<210>  182
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  182

Gln Arg Ser Asn Leu Ala Arg 
1               5           


<210>  183
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  183

Gln Arg Ser Asn Leu Val Arg 
1               5           


<210>  184
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  184

Gln Arg Thr Asn Leu Gln Arg 
1               5           


<210>  185
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  185

Gln Ser Gly Asn Leu Ala Arg 
1               5           


<210>  186
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  186

Gln Ser Asn Asn Leu Asn Arg 
1               5           


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  187

Gln Ser Ser Asn Leu Thr Lys 
1               5           


<210>  188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  188

Gln Ser Ser Asn Leu Thr Arg 
1               5           


<210>  189
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  189

Gln Ser Ser Asn Leu Val Arg 
1               5           


<210>  190
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  190

Gln Thr Asn Asn Leu Gly Arg 
1               5           


<210>  191
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  191

Gln Thr Asn Asn Leu Asn Arg 
1               5           


<210>  192
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  192

Gln Thr Asn Asn Leu Thr Arg 
1               5           


<210>  193
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  193

Gln Thr Val Asn Leu Asp Arg 
1               5           


<210>  194
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  194

Arg Lys Pro Asn Leu Leu Arg 
1               5           


<210>  195
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  195

Thr Thr Thr Asn Leu Arg Arg 
1               5           


<210>  196
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  196

Cys Pro Ser Asn Leu Arg Arg 
1               5           


<210>  197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  197

Asp Asp Ala Asn Leu Arg Arg 
1               5           


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  198

Asp Glu Ala Asn Leu Arg Arg 
1               5           


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  199

Asp Leu Ser Asn Leu Lys Arg 
1               5           


<210>  200
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  200

Asp Met Gly Asn Leu Gly Arg 
1               5           


<210>  201
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  201

Asp Pro Ala Asn Leu Arg Arg 
1               5           


<210>  202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  202

Asp Pro Gly Asn Leu Val Arg 
1               5           


<210>  203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  203

Asp Pro Ser Asn Leu Ile Arg 
1               5           


<210>  204
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  204

Asp Pro Ser Asn Leu Gln Arg 
1               5           


<210>  205
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  205

Asp Pro Ser Asn Leu Arg Arg 
1               5           


<210>  206
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  206

Asp Gln Gly Asn Leu Ile Arg 
1               5           


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  207

Asp Arg Ala Asn Leu Ser Arg 
1               5           


<210>  208
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  208

Asp Arg Gly Asn Leu Thr Arg 
1               5           


<210>  209
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  209

Asp Arg Ser Asn Leu Thr Arg 
1               5           


<210>  210
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  210

Glu Glu Ala Asn Leu Arg Arg 
1               5           


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  211

Glu Glu Ser Asn Leu Arg Arg 
1               5           


<210>  212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  212

Glu Glu Val Asn Leu Arg Arg 
1               5           


<210>  213
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  213

Glu Gly Gly Asn Leu Met Arg 
1               5           


<210>  214
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  214

Glu Lys Ala Asn Leu Thr Arg 
1               5           


<210>  215
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  215

Glu Gln Ala Asn Leu Arg Arg 
1               5           


<210>  216
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  216

His Ser Ser Asn Phe Asn Lys 
1               5           


<210>  217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  217

Arg Ser Asp Asn Leu Ser Glu 
1               5           


<210>  218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  218

Lys His Ser Asn Leu Ala Arg 
1               5           


<210>  219
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  219

Lys His Ser Asn Leu Thr Arg 
1               5           


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  220

Lys Lys Thr Asn Leu Thr Arg 
1               5           


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  221

Lys Ser Ser Asn Leu Arg Arg 
1               5           


<210>  222
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  222

Gln Ser Phe Asn Leu Arg Arg 
1               5           


<210>  223
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  223

Arg Glu Asp Asn Leu Gly Arg 
1               5           


<210>  224
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  224

Arg Gly Asp Asn Leu Lys Arg 
1               5           


<210>  225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  225

Arg Gly Asp Asn Leu Asn Arg 
1               5           


<210>  226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  226

Arg His Asp Gln Leu Thr Arg 
1               5           


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  227

Arg Ile Asp Asn Leu Gly Arg 
1               5           


<210>  228
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  228

Arg Lys Ser Asn Leu Ile Arg 
1               5           


<210>  229
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  229

Arg Met Ser Asn Leu Asp Arg 
1               5           


<210>  230
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  230

Arg Asn Thr Asn Leu Thr Arg 
1               5           


<210>  231
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  231

Arg Pro His Asn Leu Leu Arg 
1               5           


<210>  232
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  232

Arg Gln Asp Asn Leu Gly Arg 
1               5           


<210>  233
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  233

Arg Gln Asp Asn Leu Gln Arg 
1               5           


<210>  234
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  234

Arg Gln Met Asn Leu Asp Arg 
1               5           


<210>  235
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  235

Arg Arg Asp Asn Leu Leu Arg 
1               5           


<210>  236
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  236

Arg Arg Asp Asn Leu Asn Arg 
1               5           


<210>  237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  237

Arg Ser Ala Asn Leu Thr Arg 
1               5           


<210>  238
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  238

Arg Ser Asp His Leu Ser Arg 
1               5           


<210>  239
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  239

Arg Ser Asp Asn Leu Ala Arg 
1               5           


<210>  240
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  240

Arg Ser Asp Asn Leu Ser Arg 
1               5           


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  241

Arg Ser Asp Asn Leu Ser Thr 
1               5           


<210>  242
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  242

Arg Ser Asp Asn Leu Thr Arg 
1               5           


<210>  243
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  243

Arg Ser Asp Asn Leu Val Arg 
1               5           


<210>  244
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  244

Arg Ser Ser Asn Leu Gln Arg 
1               5           


<210>  245
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  245

Arg Thr His Asn Leu Lys Arg 
1               5           


<210>  246
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  246

Arg Thr His Asn Leu Thr Arg 
1               5           


<210>  247
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  247

Arg Val Asp Asn Leu Pro Arg 
1               5           


<210>  248
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  248

Ser Gly Ser Asn Phe Thr Arg 
1               5           


<210>  249
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  249

Thr Asn Asn Asn Leu Ala Arg 
1               5           


<210>  250
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  250

Val His Trp Asn Leu Met Arg 
1               5           


<210>  251
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  251

Ile Ser His Asn Leu Ala Arg 
1               5           


<210>  252
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  252

Ile Ser Ser Asn Leu Gln Arg 
1               5           


<210>  253
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  253

Leu Gly Asn Asn Leu Lys Arg 
1               5           


<210>  254
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  254

Leu Asn Ser Asn Leu Ala Arg 
1               5           


<210>  255
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  255

Leu Ser Thr Asn Leu Thr Arg 
1               5           


<210>  256
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  256

Leu Thr His Asn Leu Arg Arg 
1               5           


<210>  257
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  257

Gln Ser Ser Asn Leu Ala Arg 
1               5           


<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  258

Arg Ser Asp Ala Leu Ile Gln 
1               5           


<210>  259
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  259

Ser Lys Gln Ala Leu Ala Val 
1               5           


<210>  260
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  260

Thr Gly Gln Gln Leu Arg Val 
1               5           


<210>  261
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  261

Thr Lys Gln Arg Leu Val Val 
1               5           


<210>  262
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  262

Thr Arg Gln Arg Leu Arg Ile 
1               5           


<210>  263
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  263

Thr Ser Ala Asn Leu Ser Arg 
1               5           


<210>  264
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  264

Thr Ser Gly Asn Leu Val Arg 
1               5           


<210>  265
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  265

Thr Ser Gln Met Leu Val Val 
1               5           


<210>  266
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  266

Thr Ser Ser Asn Leu Ser Arg 
1               5           


<210>  267
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  267

Thr Thr Ser Asn Leu Arg Arg 
1               5           


<210>  268
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  268

Val Gly His Asn Leu Ser Arg 
1               5           


<210>  269
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  269

Val Gly Ser Asn Leu Thr Arg 
1               5           


<210>  270
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  270

Val Arg His Asn Leu Thr Arg 
1               5           


<210>  271
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  271

Asp Lys Ala Gln Leu Gly Arg 
1               5           


<210>  272
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  272

Asp Arg Ser Ala Leu Ser Arg 
1               5           


<210>  273
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  273

Asp Arg Ser Gln Leu Ala Arg 
1               5           


<210>  274
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  274

Glu Arg Gly Thr Leu Ala Arg 
1               5           


<210>  275
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  275

His Asn Gly Thr Leu Lys Arg 
1               5           


<210>  276
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  276

Lys Asn Thr Arg Leu Ser Val 
1               5           


<210>  277
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  277

Leu Lys His Ser Leu Leu Arg 
1               5           


<210>  278
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  278

Leu Asn His Thr Leu Lys Arg 
1               5           


<210>  279
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  279

Leu Arg His Ser Leu Ser Arg 
1               5           


<210>  280
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  280

Gln Asp Asn Thr Leu Arg Arg 
1               5           


<210>  281
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  281

Gln Asp Val Ser Leu Val Arg 
1               5           


<210>  282
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  282

Gln Gly Gly Thr Leu Arg Arg 
1               5           


<210>  283
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  283

Gln Gly Asn Thr Leu Thr Arg 
1               5           


<210>  284
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  284

Gln Lys Gly Thr Leu Gly Arg 
1               5           


<210>  285
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  285

Gln Asn Gly Thr Leu Thr Arg 
1               5           


<210>  286
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  286

Gln Pro Asn Thr Leu Thr Arg 
1               5           


<210>  287
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  287

Gln Arg Gly Thr Leu Asn Arg 
1               5           


<210>  288
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  288

Gln Ser Gly Asp Leu Arg Arg 
1               5           


<210>  289
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  289

Gln Ser Gly Asp Leu Thr Arg 
1               5           


<210>  290
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  290

Gln Ser Gly Ser Leu Thr Arg 
1               5           


<210>  291
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  291

Gln Ser Asn Val Leu Ser Arg 
1               5           


<210>  292
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  292

Gln Ser Thr Thr Leu Lys Arg 
1               5           


<210>  293
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  293

Gln Thr Ala Thr Leu Lys Arg 
1               5           


<210>  294
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  294

Gln Thr Asn Thr Leu Lys Arg 
1               5           


<210>  295
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  295

Arg Gly Gln Glu Leu Arg Arg 
1               5           


<210>  296
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  296

Arg Arg Gln Glu Leu His Arg 
1               5           


<210>  297
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  297

Arg Arg Gln Glu Leu Lys Arg 
1               5           


<210>  298
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  298

Arg Arg Gln Glu Leu Thr Arg 
1               5           


<210>  299
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  299

Arg Arg Val Asp Leu Leu Arg 
1               5           


<210>  300
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  300

Ser Pro Glu Gln Leu Ala Arg 
1               5           


<210>  301
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  301

Asp Cys Arg Asp Leu Ala Arg 
1               5           


<210>  302
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  302

Asp Gly Ser Thr Leu Asn Arg 
1               5           


<210>  303
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  303

Asp Gly Ser Thr Leu Arg Arg 
1               5           


<210>  304
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  304

Asp His Ser Asn Leu Ser Arg 
1               5           


<210>  305
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  305

Asp Lys Ser Cys Leu Asn Arg 
1               5           


<210>  306
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  306

Asp Lys Ser Val Leu Ala Arg 
1               5           


<210>  307
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  307

Asp Pro Ser Asn Leu Arg Arg 
1               5           


<210>  308
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  308

Asp Pro Ser Thr Leu Arg Arg 
1               5           


<210>  309
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  309

Asp Arg Arg Thr Leu Asp Arg 
1               5           


<210>  310
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  310

Asp Arg Ser Asp Leu Thr Arg 
1               5           


<210>  311
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  311

Asp Arg Ser Ser Leu Thr Arg 
1               5           


<210>  312
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  312

Asp Arg Ser Ser Arg Thr Lys 
1               5           


<210>  313
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  313

Asp Ser Pro Thr Leu Arg Arg 
1               5           


<210>  314
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  314

Asp Ser Ser Val Leu Arg Arg 
1               5           


<210>  315
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  315

Glu His Arg Gly Leu Lys Arg 
1               5           


<210>  316
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  316

Glu Arg Gly Thr Leu Ala Arg 
1               5           


<210>  317
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  317

Glu Arg Arg Gly Leu Ala Arg 
1               5           


<210>  318
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  318

Glu Arg Arg Gly Leu Asp Arg 
1               5           


<210>  319
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  319

Lys Arg Arg Asp Leu Asp Arg 
1               5           


<210>  320
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  320

Leu Lys Lys Asp Leu Leu Arg 
1               5           


<210>  321
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  321

Ser His Thr Val Leu Thr Arg 
1               5           


<210>  322
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  322

Ser Lys Lys Ser Leu Thr Arg 
1               5           


<210>  323
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  323

Ser Asn Lys Asp Leu Thr Arg 
1               5           


<210>  324
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  324

Val Arg Lys Asp Leu Thr Arg 
1               5           


<210>  325
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  325

Lys Ala Asp Thr Leu Val Arg 
1               5           


<210>  326
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  326

Lys His Asp Thr Leu His Arg 
1               5           


<210>  327
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  327

Lys Asn Asn Asp Leu Thr Arg 
1               5           


<210>  328
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  328

Arg Ala Asp Thr Leu Arg Arg 
1               5           


<210>  329
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  329

Arg Ala His Thr Leu Arg Arg 
1               5           


<210>  330
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  330

Arg Glu Asp Ser Leu Pro Arg 
1               5           


<210>  331
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  331

Arg His Ala Ala Leu Leu Ser 
1               5           


<210>  332
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  332

Arg Lys Asp Gly Leu Thr Arg 
1               5           


<210>  333
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  333

Arg Lys Gly Thr Leu Asp Arg 
1               5           


<210>  334
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  334

Arg Lys Leu Gly Leu Leu Arg 
1               5           


<210>  335
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  335

Arg Leu Asp Met Leu Ala Arg 
1               5           


<210>  336
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  336

Arg Leu Arg Asp Leu Pro Arg 
1               5           


<210>  337
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  337

Arg Asn Leu Thr Leu Ala Arg 
1               5           


<210>  338
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  338

Arg Asn Leu Thr Leu Val Arg 
1               5           


<210>  339
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  339

Arg Pro Asp Gly Leu Ala Arg 
1               5           


<210>  340
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  340

Arg Arg Asp Asp Leu Thr Arg 
1               5           


<210>  341
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  341

Arg Arg Asp Gly Leu Thr Arg 
1               5           


<210>  342
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  342

Arg Arg His Gly Leu Asp Arg 
1               5           


<210>  343
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  343

Arg Arg His Thr Leu Thr Arg 
1               5           


<210>  344
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  344

Arg Arg Leu Thr Leu Leu Arg 
1               5           


<210>  345
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  345

Arg Ser Asp Asp Leu Gln Arg 
1               5           


<210>  346
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  346

Arg Ser Asp Asp Leu Thr Arg 
1               5           


<210>  347
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  347

Arg Ser Asp Asp Leu Val Arg 
1               5           


<210>  348
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  348

Arg Ser Asp Glu Leu Asn Arg 
1               5           


<210>  349
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  349

Arg Ser Asp Glu Leu Gln Arg 
1               5           


<210>  350
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  350

Arg Ser Asp Glu Leu Ser Arg 
1               5           


<210>  351
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  351

Arg Ser Asp Glu Leu Thr Arg 
1               5           


<210>  352
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  352

Arg Ser Asp Glu Arg Lys Arg 
1               5           


<210>  353
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  353

Arg Ser Asp Ser Leu Ser Lys 
1               5           


<210>  354
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  354

Arg Ser Asp Thr Leu Lys Lys 
1               5           


<210>  355
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  355

Arg Ser Asp Val Leu Thr Arg 
1               5           


<210>  356
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  356

Arg Ser Asn Thr Leu Leu Arg 
1               5           


<210>  357
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  357

Arg Thr Asp Leu Leu Arg Arg 
1               5           


<210>  358
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  358

Arg Thr Asp Ser Leu Pro Arg 
1               5           


<210>  359
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  359

Arg Thr Asp Thr Leu Ala Arg 
1               5           


<210>  360
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  360

Arg Val Asp Asp Leu Gly Arg 
1               5           


<210>  361
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  361

Ala Arg Ser Thr Arg Thr Thr 
1               5           


<210>  362
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  362

Glu Gly Ser Gly Leu Lys Arg 
1               5           


<210>  363
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  363

Gly Ala Thr Ala Leu Lys Arg 
1               5           


<210>  364
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  364

Lys His Gln Thr Leu Gln Arg 
1               5           


<210>  365
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  365

Leu Lys His Asp Leu Arg Arg 
1               5           


<210>  366
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  366

Leu Arg Ala Ser Leu Arg Arg 
1               5           


<210>  367
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  367

Leu Arg Gln Thr Leu Ala Arg 
1               5           


<210>  368
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  368

Leu Arg Thr Ser Leu Val Arg 
1               5           


<210>  369
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  369

Met Lys Asn Thr Leu Thr Arg 
1               5           


<210>  370
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  370

Asn Gly Gln Gly Leu Arg Arg 
1               5           


<210>  371
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  371

Asn Lys Gln Ala Leu Asp Arg 
1               5           


<210>  372
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  372

Asn Arg Ser Asp Arg Thr Arg 
1               5           


<210>  373
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  373

Gln Arg Gln Ala Leu Asp Arg 
1               5           


<210>  374
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  374

Gln Arg Ser Asp Leu His Arg 
1               5           


<210>  375
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  375

Gln Arg Ser Asp Leu Thr Arg 
1               5           


<210>  376
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  376

Gln Ser Ser Asp Leu Gln Arg 
1               5           


<210>  377
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  377

Gln Ser Ser Asp Leu Arg Arg 
1               5           


<210>  378
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  378

Gln Ser Ser Asp Leu Ser Arg 
1               5           


<210>  379
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  379

Gln Ser Ser Asp Leu Thr Arg 
1               5           


<210>  380
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  380

Thr His Ser Met Leu Ala Arg 
1               5           


<210>  381
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  381

Thr Lys Pro Ile Leu Val Arg 
1               5           


<210>  382
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  382

Thr Lys Gln Ile Leu Gly Arg 
1               5           


<210>  383
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  383

Thr Lys Gln Val Leu Asp Arg 
1               5           


<210>  384
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  384

Thr Ser Gly Glu Leu Val Arg 
1               5           


<210>  385
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  385

Thr Ser Ser Gly Leu Thr Arg 
1               5           


<210>  386
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  386

Thr Thr Gln Ala Leu Arg Arg 
1               5           


<210>  387
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  387

Val Gly Ala Ser Leu Lys Arg 
1               5           


<210>  388
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  388

Val Gly Asn Ser Leu Thr Arg 
1               5           


<210>  389
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  389

Val Lys Asn Thr Leu Thr Arg 
1               5           


<210>  390
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  390

Val Arg Gln Gly Leu Thr Arg 
1               5           


<210>  391
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  391

Val Ser Asn Ser Leu Ala Arg 
1               5           


<210>  392
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  392

Val Ser Asn Thr Leu Thr Arg 
1               5           


<210>  393
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  393

Asp Lys Thr Lys Leu Asn Val 
1               5           


<210>  394
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  394

Asp Lys Thr Lys Leu Arg Val 
1               5           


<210>  395
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  395

Asp Asn Ala His Leu Ala Arg 
1               5           


<210>  396
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  396

Gln Ala Asn His Leu Ser Arg 
1               5           


<210>  397
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  397

Gln Gly Gly His Leu Lys Arg 
1               5           


<210>  398
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  398

Gln His Ser His Leu Val Arg 
1               5           


<210>  399
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  399

Gln Lys Pro His Leu Ser Arg 
1               5           


<210>  400
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  400

Gln Met Ser His Leu Lys Arg 
1               5           


<210>  401
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  401

Gln Asn Ser His Leu Arg Arg 
1               5           


<210>  402
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  402

Gln Asn Ser His Leu Arg Arg 
1               5           


<210>  403
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  403

Gln Arg Ala His Leu Glu Arg 
1               5           


<210>  404
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  404

Gln Arg Ala His Leu Ile Arg 
1               5           


<210>  405
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  405

Gln Ser Ala His Leu Lys Arg 
1               5           


<210>  406
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  406

Gln Ser Gly His Leu Ala Arg 
1               5           


<210>  407
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  407

Gln Ser Gly His Leu Gln Arg 
1               5           


<210>  408
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  408

Gln Ser Gly His Leu Ser Arg 
1               5           


<210>  409
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  409

Gln Ser Gln His Leu Val Arg 
1               5           


<210>  410
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  410

Gln Ser Thr His Leu Thr Arg 
1               5           


<210>  411
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  411

Gln Thr Thr His Leu Arg Arg 
1               5           


<210>  412
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  412

Gln Thr Thr His Leu Ser Arg 
1               5           


<210>  413
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  413

Gln Thr Thr His Leu Ser Arg 
1               5           


<210>  414
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  414

Gln Val Ser His Leu Thr Arg 
1               5           


<210>  415
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  415

Arg Met Glu Arg Leu Asp Arg 
1               5           


<210>  416
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  416

Arg Pro Ala Lys Leu Val Leu 
1               5           


<210>  417
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  417

Arg Pro Ser Lys Leu Val Leu 
1               5           


<210>  418
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  418

Arg Arg Asp His Arg Thr Thr 
1               5           


<210>  419
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  419

Arg Ser Thr His Leu Arg Val 
1               5           


<210>  420
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  420

Arg Thr Asp Arg Leu Ile Arg 
1               5           


<210>  421
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  421

Thr His Ala His Leu Thr Arg 
1               5           


<210>  422
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  422

Thr Ser Ala His Leu Ala Arg 
1               5           


<210>  423
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  423

Tyr Asn Thr His Leu Thr Arg 
1               5           


<210>  424
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  424

Ala Lys Ser Lys Leu Asp Arg 
1               5           


<210>  425
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  425

Ala Pro Ser Lys Leu Asp Arg 
1               5           


<210>  426
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  426

Asp Gly Gly His Leu Thr Arg 
1               5           


<210>  427
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  427

Asp Lys Ser His Leu Pro Arg 
1               5           


<210>  428
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  428

Asp Pro Gly His Leu Val Arg 
1               5           


<210>  429
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  429

Asp Arg Ser His Leu Ala Arg 
1               5           


<210>  430
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  430

Asp Arg Ser His Leu Ser Arg 
1               5           


<210>  431
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  431

Asp Arg Ser His Leu Thr Arg 
1               5           


<210>  432
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  432

Glu Lys Ser His Leu Lys Arg 
1               5           


<210>  433
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  433

Glu Lys Ser His Leu Thr Arg 
1               5           


<210>  434
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  434

Glu Asn Ser Lys Leu Asn Arg 
1               5           


<210>  435
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  435

Glu Ser Gly His Leu Lys Arg 
1               5           


<210>  436
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  436

Glu Ser Gly His Leu Arg Arg 
1               5           


<210>  437
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  437

Lys Asn His Ser Leu Asn Asn 
1               5           


<210>  438
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  438

Lys Asn Val Ser Leu Thr His 
1               5           


<210>  439
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  439

Leu Lys Glu His Leu Thr Arg 
1               5           


<210>  440
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  440

Gln Ser Ser His Leu Ala Arg 
1               5           


<210>  441
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  441

Ser Lys His Lys Leu Glu Arg 
1               5           


<210>  442
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  442

Ser Pro Ser Lys Leu Ala Arg 
1               5           


<210>  443
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  443

Ser Pro Ser Lys Leu Val Arg 
1               5           


<210>  444
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  444

Thr Asn Ser Lys Leu Thr Arg 
1               5           


<210>  445
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  445

Thr Pro Ser Lys Leu Asp Arg 
1               5           


<210>  446
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  446

Thr Arg Ala Lys Leu His Ile 
1               5           


<210>  447
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  447

Val Pro Ser Lys Leu Ala Arg 
1               5           


<210>  448
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  448

Val Pro Ser Lys Leu Lys Arg 
1               5           


<210>  449
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  449

Val Pro Ser Lys Leu Leu Arg 
1               5           


<210>  450
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  450

Lys Gly Asp His Leu Arg Arg 
1               5           


<210>  451
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  451

Lys Lys Asp His Leu His Arg 
1               5           


<210>  452
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  452

Lys Arg Glu Arg Leu Asp Arg 
1               5           


<210>  453
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  453

Lys Arg Glu Arg Leu Glu Arg 
1               5           


<210>  454
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  454

Lys Ser Asn His Leu His Val 
1               5           


<210>  455
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  455

Lys Thr Ser His Leu Arg Ala 
1               5           


<210>  456
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  456

Arg Gly Asp Lys Leu Ala Leu 
1               5           


<210>  457
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  457

Arg Gly Asp Lys Leu Gly Pro 
1               5           


<210>  458
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  458

Arg Gly Asn His Leu Arg Arg 
1               5           


<210>  459
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  459

Arg Ile Asp Lys Leu Gly Gly 
1               5           


<210>  460
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  460

Arg Lys His His Leu Gly Arg 
1               5           


<210>  461
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  461

Arg Lys His Arg Leu Asp Gly 
1               5           


<210>  462
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  462

Arg Asn Asp Lys Leu Val Pro 
1               5           


<210>  463
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  463

Arg Asn His Gly Leu Val Arg 
1               5           


<210>  464
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  464

Arg Asn Thr His Leu Ala Arg 
1               5           


<210>  465
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  465

Arg Gln Gly His Leu Lys Arg 
1               5           


<210>  466
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  466

Arg Arg Ala His Leu Gln Asn 
1               5           


<210>  467
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  467

Arg Arg Glu His Leu Val Arg 
1               5           


<210>  468
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  468

Arg Arg Ser His Leu Thr Arg 
1               5           


<210>  469
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  469

Arg Ser Ala His Leu Ala Arg 
1               5           


<210>  470
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  470

Arg Ser Ala His Leu Ser Arg 
1               5           


<210>  471
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  471

Arg Ser Asp His Leu Ala Arg 
1               5           


<210>  472
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  472

Arg Ser Asp His Leu Ser Lys 
1               5           


<210>  473
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  473

Arg Ser Asp His Leu Ser Arg 
1               5           


<210>  474
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  474

Arg Ser Asp His Leu Thr Arg 
1               5           


<210>  475
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  475

Arg Ser Asp Lys Leu Asn Arg 
1               5           


<210>  476
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  476

Arg Ser Asp Lys Leu Val Arg 
1               5           


<210>  477
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  477

Arg Thr Glu His Leu Ala Arg 
1               5           


<210>  478
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  478

Asp Ser Ser Lys Leu Ser Arg 
1               5           


<210>  479
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  479

Glu Ala His His Leu Ser Arg 
1               5           


<210>  480
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  480

His Gly His Arg Leu Lys Thr 
1               5           


<210>  481
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  481

Ile Pro Asn His Leu Ala Arg 
1               5           


<210>  482
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  482

Ile Arg His His Leu Lys Arg 
1               5           


<210>  483
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  483

Leu Thr Gln Gly Leu Arg Arg 
1               5           


<210>  484
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  484

Met Gly His His Leu Lys Arg 
1               5           


<210>  485
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  485

Met Lys His His Leu Ala Arg 
1               5           


<210>  486
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  486

Met Lys His His Leu Asp Ala 
1               5           


<210>  487
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  487

Met Ser Asp His Leu Ser Arg 
1               5           


<210>  488
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  488

Met Ser His His Leu Ser Arg 
1               5           


<210>  489
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  489

Gln Pro His His Leu Pro Arg 
1               5           


<210>  490
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  490

Gln Ser Ser His Leu Ala Arg 
1               5           


<210>  491
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  491

Gln Ser Ser His Leu Thr Arg 
1               5           


<210>  492
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  492

Arg Gln Ser Arg Leu Gln Arg 
1               5           


<210>  493
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  493

Arg Arg Gln Lys Leu Thr Ile 
1               5           


<210>  494
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  494

Arg Arg Ser Arg Leu Val Arg 
1               5           


<210>  495
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  495

Arg Ser Asp His Leu Ser Thr 
1               5           


<210>  496
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  496

Arg Ser Asp His Leu Thr Thr 
1               5           


<210>  497
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  497

Thr Lys Gln Lys Leu Gln Thr 
1               5           


<210>  498
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  498

Thr Lys Gln Arg Leu Glu Val 
1               5           


<210>  499
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  499

Thr Arg Gln Lys Leu Glu Thr 
1               5           


<210>  500
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  500

Thr Arg Thr Arg Leu Val Ile 
1               5           


<210>  501
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  501

Thr Ser Gly His Leu Ser Arg 
1               5           


<210>  502
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  502

Thr Ser Gly His Leu Val Arg 
1               5           


<210>  503
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  503

Thr Thr Thr Lys Leu Ala Ile 
1               5           


<210>  504
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  504

Val Asp His His Leu Arg Arg 
1               5           


<210>  505
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  505

Val Lys His Gly Leu Gly Arg 
1               5           


<210>  506
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  506

Val Lys His Gly Leu Thr Arg 
1               5           


<210>  507
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  507

Trp Pro Ser Asn Leu Thr Arg 
1               5           


<210>  508
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  508

Tyr Asn Trp His Leu Gln Arg 
1               5           


<210>  509
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  509

Gln Gly Gly Ala Leu Gln Arg 
1               5           


<210>  510
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  510

Gln Gly Thr Ser Leu Ala Arg 
1               5           


<210>  511
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  511

Gln Lys Gln Ala Leu Asp Arg 
1               5           


<210>  512
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  512

Gln Lys Gln Ala Leu Thr Arg 
1               5           


<210>  513
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  513

Gln Lys Val Ser Leu Lys Arg 
1               5           


<210>  514
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  514

Gln Met Asn Ala Leu Gln Arg 
1               5           


<210>  515
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  515

Gln Gln Gln Ala Leu Lys Arg 
1               5           


<210>  516
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  516

Gln Gln Gln Ala Leu Thr Arg 
1               5           


<210>  517
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  517

Gln Gln Gln Ala Leu Val Arg 
1               5           


<210>  518
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  518

Gln Gln Ser Ser Leu Leu Arg 
1               5           


<210>  519
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  519

Gln Arg Ala Ser Leu Thr Arg 
1               5           


<210>  520
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  520

Gln Arg Ser Ser Leu Val Arg 
1               5           


<210>  521
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  521

Gln Ser Gly Ala Leu Ala Arg 
1               5           


<210>  522
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  522

Gln Ser Gly Ala Leu Thr Arg 
1               5           


<210>  523
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  523

Gln Ser Gly Ser Leu Thr Arg 
1               5           


<210>  524
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  524

Gln Ser Gly Thr Leu Thr Arg 
1               5           


<210>  525
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  525

Gln Ser Ser Ser Leu Ile Arg 
1               5           


<210>  526
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  526

Gln Ser Ser Ser Leu Val Arg 
1               5           


<210>  527
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  527

Gln Ser Ser Thr Leu Thr Arg 
1               5           


<210>  528
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  528

Gln Ser Thr Ser Leu Gln Arg 
1               5           


<210>  529
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  529

Thr Ser Ser Ala Arg Thr Thr 
1               5           


<210>  530
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  530

Ala Pro Ser Ser Leu Arg Arg 
1               5           


<210>  531
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  531

Asp Ala Thr Gln Leu Val Arg 
1               5           


<210>  532
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  532

Asp His Ser Ser Leu Lys Arg 
1               5           


<210>  533
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  533

Asp Pro Gly Ala Leu Val Arg 
1               5           


<210>  534
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  534

Asp Pro Thr Ser Leu Asn Arg 
1               5           


<210>  535
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  535

Asp Arg Ser Ala Leu Ala Arg 
1               5           


<210>  536
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  536

Asp Arg Ser Ala Leu Ser Arg 
1               5           


<210>  537
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  537

Asp Arg Ser Ser Leu Arg Arg 
1               5           


<210>  538
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  538

Asp Arg Thr Pro Leu Asn Arg 
1               5           


<210>  539
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  539

Asp Arg Thr Pro Leu Gln Asn 
1               5           


<210>  540
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  540

Asp Arg Thr Ser Leu Ala Arg 
1               5           


<210>  541
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  541

Glu Gly Gly Ala Leu Arg Arg 
1               5           


<210>  542
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  542

Glu Ser Gly Ala Leu Arg Arg 
1               5           


<210>  543
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  543

Asn Thr Ser Leu Leu Arg Arg 
1               5           


<210>  544
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  544

Arg Ser Asp Val Leu Ser Glu 
1               5           


<210>  545
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  545

Thr Gly Ala Val Leu Arg Arg 
1               5           


<210>  546
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  546

Thr Gly Ala Val Leu Thr Arg 
1               5           


<210>  547
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  547

Thr Lys Lys Ile Leu Thr Val 
1               5           


<210>  548
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  548

Thr Lys Ser Leu Leu Ala Arg 
1               5           


<210>  549
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  549

Thr Met Ala Val Leu Arg Arg 
1               5           


<210>  550
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  550

Thr Arg Ala Val Leu Arg Arg 
1               5           


<210>  551
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  551

Thr Ser Thr Ile Leu Ala Arg 
1               5           


<210>  552
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  552

Thr Ser Thr Leu Leu Lys Arg 
1               5           


<210>  553
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  553

Thr Ser Thr Leu Leu Asn Arg 
1               5           


<210>  554
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  554

Arg Ala Ser Val Leu Asp Ile 
1               5           


<210>  555
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  555

Arg Gly Asp Ala Leu Ala Arg 
1               5           


<210>  556
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  556

Arg His Thr Ser Leu Thr Arg 
1               5           


<210>  557
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  557

Arg Lys Asp Ala Leu His Val 
1               5           


<210>  558
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  558

Arg Lys His Ile Leu Ile His 
1               5           


<210>  559
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  559

Arg Lys Thr Ala Leu Asn Arg 
1               5           


<210>  560
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  560

Arg Asn Phe Ile Leu Ala Arg 
1               5           


<210>  561
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  561

Arg Asn Phe Ile Leu Gln Arg 
1               5           


<210>  562
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  562

Arg Asn Phe Val Leu Ala Arg 
1               5           


<210>  563
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  563

Arg Asn Thr Ala Leu Gln His 
1               5           


<210>  564
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  564

Arg Asn Val Ala Leu Gly Asn 
1               5           


<210>  565
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  565

Arg Asn Val Asn Leu Val Thr 
1               5           


<210>  566
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  566

Arg Pro Asp Ala Leu Pro Arg 
1               5           


<210>  567
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  567

Arg Arg Ala Ala Leu Gly Pro 
1               5           


<210>  568
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  568

Arg Arg Glu Val Leu Glu Asn 
1               5           


<210>  569
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  569

Arg Arg Phe Ile Leu Ser Arg 
1               5           


<210>  570
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  570

Arg Arg His Ile Leu Asp Arg 
1               5           


<210>  571
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  571

Arg Ser Ala Ala Leu Ser Arg 
1               5           


<210>  572
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  572

Arg Ser Asp Ala Leu Ala Arg 
1               5           


<210>  573
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  573

Arg Ser Asp Ala Leu Arg Thr 
1               5           


<210>  574
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  574

Arg Ser Asp Ala Leu Ser Arg 
1               5           


<210>  575
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  575

Arg Ser Asp Ala Leu Thr Arg 
1               5           


<210>  576
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  576

Arg Ser Asp Glu Leu Val Arg 
1               5           


<210>  577
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  577

Arg Ser His Ile Leu Thr Asn 
1               5           


<210>  578
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  578

Arg Thr Ser Ser Leu Lys Arg 
1               5           


<210>  579
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  579

Arg Thr Val Ala Leu Asn Arg 
1               5           


<210>  580
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  580

Ser Arg Phe Thr Leu Gly Arg 
1               5           


<210>  581
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  581

Ser Arg Phe Thr Leu Gly Arg 
1               5           


<210>  582
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  582

Val Ser Ser Ser Leu Arg Arg 
1               5           


<210>  583
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  583

Ala Ala Thr Ala Leu Arg Arg 
1               5           


<210>  584
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  584

His His Asn Ser Leu Thr Arg 
1               5           


<210>  585
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  585

His Lys Ser Ser Leu Thr Arg 
1               5           


<210>  586
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  586

His Ser Ser Ser Leu Val Arg 
1               5           


<210>  587
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  587

Ile Lys Ala Ile Leu Thr Arg 
1               5           


<210>  588
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  588

Ile Asn His Ser Leu Arg Arg 
1               5           


<210>  589
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  589

Ile Arg Thr Ser Leu Lys Arg 
1               5           


<210>  590
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  590

Met Asn Ser Val Leu Lys Arg 
1               5           


<210>  591
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  591

Met Thr Ser Ser Leu Arg Arg 
1               5           


<210>  592
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  592

Gln Ala Thr Leu Leu Arg Arg 
1               5           


<210>  593
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  593

Gln Ser Ser Ala Leu Thr Arg 
1               5           


<210>  594
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  594

Thr His Thr Val Leu Ala Arg 
1               5           


<210>  595
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  595

Thr Lys Pro Val Leu Lys Ile 
1               5           


<210>  596
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  596

Thr Asn Gln Ala Leu Gly Val 
1               5           


<210>  597
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  597

Thr Asn Ser Val Leu Gly Arg 
1               5           


<210>  598
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  598

Thr Arg His Ser Leu Gly Arg 
1               5           


<210>  599
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  599

Thr Ser Gly Ala Leu Thr Arg 
1               5           


<210>  600
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  600

Thr Ser Gly Ser Leu Thr Arg 
1               5           


<210>  601
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  601

Thr Ser Gly Ser Leu Val Arg 
1               5           


<210>  602
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  602

Thr Ser Thr Leu Leu Lys Arg 
1               5           


<210>  603
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  603

Thr Ser Thr Arg Leu Asp Ile 
1               5           


<210>  604
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  604

Thr Thr Ala Leu Leu Lys Arg 
1               5           


<210>  605
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  605

Thr Thr Ser Ala Leu Thr Arg 
1               5           


<210>  606
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  606

Thr Thr Thr Val Leu Ala Arg 
1               5           


<210>  607
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  607

Val Gly Gly Ser Leu Asn Arg 
1               5           


<210>  608
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  608

Gln Gly Gly Asn Leu Ala Leu 
1               5           


<210>  609
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  609

Gln Gly Gly Asn Leu Thr Leu 
1               5           


<210>  610
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  610

Gln Gln Gly Asn Leu Gln Leu 
1               5           


<210>  611
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  611

Gln Gln Gly Asn Leu Arg Asn 
1               5           


<210>  612
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  612

Gln Arg Gly Asn Leu Asn Met 
1               5           


<210>  613
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  613

Gln Ser Gly Asn Leu His Thr 
1               5           


<210>  614
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  614

Asn Ser Asp His Leu Thr Asn 
1               5           


<210>  615
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  615

Gln Gly Tyr Asn Leu Ala Gly 
1               5           


<210>  616
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  616

Arg Ala His Asn Leu Leu Leu 
1               5           


<210>  617
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  617

Arg Glu Asp Asn Leu His Thr 
1               5           


<210>  618
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  618

Arg Gly His Asn Leu Leu Val 
1               5           


<210>  619
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  619

Arg Gly Thr Asn Leu Arg Thr 
1               5           


<210>  620
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  620

Arg His Asp Gly Leu Ala Gly 
1               5           


<210>  621
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  621

Arg Ile Asp His Leu Val Pro 
1               5           


<210>  622
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  622

Arg Lys Thr Gly Leu Leu Ile 
1               5           


<210>  623
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  623

Arg Leu Asp Gly Leu Ala Gly 
1               5           


<210>  624
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  624

Arg Pro Glu Gly Leu Ser Thr 
1               5           


<210>  625
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  625

Arg Pro Glu Ser Leu Ala Pro 
1               5           


<210>  626
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  626

Arg Pro Glu Ser Leu Arg Pro 
1               5           


<210>  627
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  627

Arg Arg Asp Gly Leu Ala Gly 
1               5           


<210>  628
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  628

Arg Arg Asp His Leu Ser Leu 
1               5           


<210>  629
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  629

Arg Arg Asp His Leu Ser Pro 
1               5           


<210>  630
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  630

Arg Arg Asp Asn Leu Pro Lys 
1               5           


<210>  631
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  631

Arg Arg Arg Asn Leu Gln Ile 
1               5           


<210>  632
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  632

Arg Ser His Asn Leu Lys Leu 
1               5           


<210>  633
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  633

Arg Ser His Asn Leu Arg Leu 
1               5           


<210>  634
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  634

Thr Ser Ser Asn Arg Lys Lys 
1               5           


<210>  635
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  635

Gln Ser Ala Asp Arg Thr Lys 
1               5           


<210>  636
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  636

Asp Lys Arg Ser Leu Pro His 
1               5           


<210>  637
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  637

Ala Ser Ser Thr Arg Thr Lys 
1               5           


<210>  638
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  638

His Ser Ser Asp Leu Thr Arg 
1               5           


<210>  639
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  639

Lys Asn Asn Asp Leu Leu Lys 
1               5           


<210>  640
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  640

Asn Arg Ser Asp Leu Ser Arg 
1               5           


<210>  641
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  641

Gln Ser Ser Asp Leu Ser Lys 
1               5           


<210>  642
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  642

Arg Ala Asp Gly Leu Gln Leu 
1               5           


<210>  643
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  643

Arg Gly Asp Ser Leu Lys Lys 
1               5           


<210>  644
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  644

Arg Met Asp Ser Leu Gly Gly 
1               5           


<210>  645
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  645

Arg Arg Asp Gly Leu Ser Gly 
1               5           


<210>  646
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  646

Arg Ser Asp Glu Leu Arg Thr 
1               5           


<210>  647
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  647

Arg Ser Asp Gly Leu Arg Gly 
1               5           


<210>  648
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  648

Arg Ser Asp Thr Leu Pro Ala 
1               5           


<210>  649
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  649

Arg Ser Asp Thr Leu Pro Leu 
1               5           


<210>  650
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  650

Arg Ser Ser Asp Leu Ser Arg 
1               5           


<210>  651
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  651

Arg Thr Asp Ser Leu Gln Pro 
1               5           


<210>  652
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  652

Asn Asn Arg Asp Arg Thr Lys 
1               5           


<210>  653
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  653

Gln Arg Asn Thr Leu Lys Gly 
1               5           


<210>  654
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  654

Ser Lys Pro Asn Leu Lys Met 
1               5           


<210>  655
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  655

Gln Ala Gly His Leu Ala Ser 
1               5           


<210>  656
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  656

Gln Arg Glu His Leu Thr Thr 
1               5           


<210>  657
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  657

Gln Ser Gly His Leu Thr Lys 
1               5           


<210>  658
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  658

Ala Asn Arg Thr Leu Val His 
1               5           


<210>  659
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  659

Gln Ala Arg Ser Leu Arg Ala 
1               5           


<210>  660
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  660

Gln Gly Arg Ser Leu Arg Ala 
1               5           


<210>  661
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  661

Gln Asn Arg Ser Leu Ala His 
1               5           


<210>  662
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  662

Gln Gln Arg Ser Leu Lys Asn 
1               5           


<210>  663
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  663

Gln Arg Arg Ser Leu Gly His 
1               5           


<210>  664
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  664

Arg Ala Arg Asn Leu Thr Leu 
1               5           


<210>  665
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  665

Arg Gly Arg Asn Leu Glu Met 
1               5           


<210>  666
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  666

Arg Lys Arg Asn Leu Ile Met 
1               5           


<210>  667
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  667

Arg Met Arg Asn Leu Ile Ile 
1               5           


<210>  668
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  668

Arg Asn Arg Asn Leu Val Leu 
1               5           


<210>  669
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  669

Arg Arg Arg Asn Leu His Leu 
1               5           


<210>  670
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  670

Arg Arg Arg Asn Leu Thr Leu 
1               5           


<210>  671
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  671

Arg Ser Arg Asn Leu Asp Ile 
1               5           


<210>  672
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  672

Arg Ser Arg Asn Leu Leu Leu 
1               5           


<210>  673
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  673

Arg Ser Arg Asn Leu Thr Leu 
1               5           


<210>  674
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  674

Arg Met Asp His Leu Ala Gly 
1               5           


<210>  675
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  675

Arg Asn Ala His Arg Ile Asn 
1               5           


<210>  676
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  676

Arg Arg Asp His Leu Ser Leu 
1               5           


<210>  677
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  677

Arg Arg Glu His Leu Thr Ile 
1               5           


<210>  678
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  678

Arg Ser Asp His Leu Arg Glu 
1               5           


<210>  679
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  679

Arg Ser Asp His Leu Ser Leu 
1               5           


<210>  680
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  680

Arg Ser Asp His Leu Ser Thr 
1               5           


<210>  681
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  681

Arg Ser Asp His Leu Thr Thr 
1               5           


<210>  682
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  682

Arg Thr Glu Ser Leu His Ile 
1               5           


<210>  683
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  683

Lys Arg Gln His Leu Glu Tyr 
1               5           


<210>  684
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  684

Gln Ala His Gly Leu Thr Ala 
1               5           


<210>  685
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  685

Gln Ala His Gly Leu Thr Gly 
1               5           


<210>  686
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  686

Gln Pro Gly His Leu Thr Ala 
1               5           


<210>  687
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  687

Gln Pro His Gly Leu Ala His 
1               5           


<210>  688
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  688

Gln Pro His Gly Leu Gly Ala 
1               5           


<210>  689
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  689

Gln Pro His Gly Leu Arg Ala 
1               5           


<210>  690
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  690

Gln Pro His Gly Leu Arg His 
1               5           


<210>  691
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  691

Gln Gln His Gly Leu Arg His 
1               5           


<210>  692
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  692

Gln Arg His Gly Leu Ser Ser 
1               5           


<210>  693
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  693

Arg His Gln His Leu Lys Leu 
1               5           


<210>  694
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  694

Arg Lys Gln His Leu Gln Leu 
1               5           


<210>  695
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  695

Arg Lys Gln His Leu Thr Leu 
1               5           


<210>  696
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  696

Arg Lys Gln His Leu Val Leu 
1               5           


<210>  697
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  697

Arg Arg Gln Ala Leu Glu Tyr 
1               5           


<210>  698
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  698

Arg Arg Gln His Leu Gln Tyr 
1               5           


<210>  699
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  699

Gln Gln Thr Gly Leu Asn Val 
1               5           


<210>  700
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  700

Gln Arg Asn Ala Leu Arg Gly 
1               5           


<210>  701
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  701

Arg Ala Asn His Leu Thr Ile 
1               5           


<210>  702
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  702

Arg Ala Asp Ala Leu Met Val 
1               5           


<210>  703
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  703

Arg Ser Asp Ser Leu Ser Ala 
1               5           


<210>  704
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  704

His Ser Asn Ala Arg Lys Thr 
1               5           


<210>  705
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recognition helices for each of the zinc finger triplet binding 
       sites

<400>  705

Gln Arg Asn Ala Leu Ser Gly 
1               5           


<210>  706
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  706

Cys Arg Cys Asn Glu Cys Gly Lys Ser Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  707
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  707

Phe Ala Cys Asp Ile Cys Gly Arg Lys Phe Ala Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Thr Lys Ile His 
            20              


<210>  708
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  708

Phe Ala Cys Glu Val Cys Gly Val Arg Phe Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Met Arg Lys His 
            20              


<210>  709
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  709

Phe Ala Cys Ser Trp Gln Asp Cys Asn Lys Lys Phe Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Tyr Arg Thr His 
            20                  25  


<210>  710
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  710

Phe Glu Cys Lys Asp Cys Gly Lys Ala Phe Ile Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  711
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  711

Phe His Cys Gly Tyr Cys Glu Lys Ser Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Ile Arg Thr His 
            20              


<210>  712
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  712

Phe Lys Cys Pro Val Cys Gly Lys Ala Phe Arg Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  713
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  713

Phe Leu Cys Gln Tyr Cys Ala Gln Arg Phe Gly Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Met Lys Lys Ser His 
            20                  


<210>  714
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  714

Phe Gln Cys Lys Thr Cys Gln Arg Lys Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Thr Arg Thr His 
            20              


<210>  715
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  715

Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Ile Lys Leu His 
            20              


<210>  716
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  716

Phe Ser Cys Ser Trp Lys Gly Cys Glu Arg Arg Phe Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Arg Arg Thr His 
            20                  25  


<210>  717
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  717

Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Ile Arg Thr His 
            20                  25              


<210>  718
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  718

His Lys Cys Leu Glu Cys Gly Lys Cys Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  719
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  719

Met Ala Glu Arg Pro Phe Gln Cys Arg Ile Cys Met Arg Lys Phe Ala 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Thr Lys Ile His 
            20                  25              


<210>  720
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  720

Pro Gly Glu Lys Lys Phe Ala Cys Pro Glu Cys Pro Lys Arg Phe Met 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Ile Lys Thr His 
            20                  25              


<210>  721
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  721

Pro Gly Glu Lys Pro Phe Glu Cys Lys Asp Cys Gly Lys Ala Phe Ile 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Arg Thr His 
            20                  25              


<210>  722
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  722

Pro Gly Glu Lys Pro Phe Lys Cys Pro Val Cys Gly Lys Ala Phe Arg 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Arg Thr His 
            20                  25              


<210>  723
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (19)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  723

Pro Gly Glu Lys Pro Phe Met Cys Thr Trp Ser Tyr Cys Gly Lys Arg 
1               5                   10                  15      


Phe Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Arg Thr His 
            20                  25                  30  


<210>  724
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  724

Pro Gly Glu Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg Lys Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Thr Arg Thr His 
            20                  25              


<210>  725
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  725

Pro Gly Glu Lys Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Ile Lys Leu His 
            20                  25              


<210>  726
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (19)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  726

Pro Gly Glu Lys Pro His Ile Cys His Ile Gln Gly Cys Gly Lys Val 
1               5                   10                  15      


Tyr Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Leu Arg Trp His 
            20                  25                  30  


<210>  727
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  727

Pro Gly Glu Lys Pro Tyr Glu Cys Asp His Cys Gly Lys Ala Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Arg Arg Ile His 
            20                  25              


<210>  728
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  728

Pro Gly Glu Lys Pro Tyr Glu Cys Asp His Cys Gly Lys Ser Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Arg Thr His 
            20                  25              


<210>  729
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  729

Pro Gly Glu Lys Pro Tyr Glu Cys Glu Lys Cys Gly Lys Ala Phe Asn 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Lys Ser His 
            20                  25              


<210>  730
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  730

Pro Gly Glu Lys Pro Tyr Glu Cys His Asp Cys Gly Lys Ser Phe Arg 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Arg Arg Ile His 
            20                  25              


<210>  731
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  731

Pro Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Arg Ile His 
            20                  25              


<210>  732
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  732

Pro Gly Glu Lys Pro Tyr Glu Cys Asn Tyr Cys Gly Lys Thr Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Arg Ile His 
            20                  25              


<210>  733
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  733

Pro Gly Glu Lys Pro Tyr Gly Cys His Leu Cys Gly Lys Ala Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Glu Met Ile His 
            20                  25              


<210>  734
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  734

Pro Gly Glu Lys Pro Tyr Ile Cys Arg Lys Cys Gly Arg Gly Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Arg Thr His 
            20                  25              


<210>  735
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  735

Pro Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Ile Val His 
            20                  25              


<210>  736
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  736

Pro Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Arg 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Ile Ile His 
            20                  25              


<210>  737
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  737

Pro Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Thr 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Lys Ile His 
            20                  25              


<210>  738
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  738

Pro Gly Glu Lys Pro Tyr Lys Cys Gly Gln Cys Gly Lys Phe Tyr Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Lys Ile His 
            20                  25              


<210>  739
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  739

Pro Gly Glu Lys Pro Tyr Lys Cys His Gln Cys Gly Lys Ala Phe Ile 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Glu Arg Thr His 
            20                  25              


<210>  740
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  740

Pro Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Asn 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His His Arg Ile His 
            20                  25              


<210>  741
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  741

Pro Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Gln Ala Phe Arg 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His His Lys Leu His 
            20                  25              


<210>  742
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  742

Pro Gly Glu Lys Pro Tyr Lys Cys Lys Gln Cys Gly Lys Ala Phe Gly 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gly Arg Thr His 
            20                  25              


<210>  743
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  743

Pro Gly Glu Lys Pro Tyr Lys Cys Met Glu Cys Gly Lys Ala Phe Asn 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Arg Ile His 
            20                  25              


<210>  744
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  744

Pro Gly Glu Lys Pro Tyr Lys Cys Pro Asp Cys Gly Lys Ser Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Arg Thr His 
            20                  25              


<210>  745
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  745

Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Arg Thr His 
            20                  25              


<210>  746
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  746

Pro Gly Glu Lys Pro Tyr Met Cys Ser Glu Cys Gly Arg Gly Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Arg Thr His 
            20                  25              


<210>  747
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  747

Pro Gly Glu Lys Pro Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe Arg 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Arg Ile His 
            20                  25              


<210>  748
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  748

Pro Gly Glu Lys Pro Tyr Arg Cys Lys Tyr Cys Asp Arg Ser Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Val Arg Asn Ile His 
            20                  25                  


<210>  749
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  749

Pro Gly Glu Lys Pro Tyr Thr Cys Lys Gln Cys Gly Lys Ala Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Glu Thr Thr His 
            20                  25              


<210>  750
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  750

Pro Gly Glu Lys Pro Tyr Thr Cys Ser Asp Cys Gly Lys Ala Phe Arg 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Arg Arg Thr His 
            20                  25              


<210>  751
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (19)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  751

Pro Gly Glu Lys Pro Tyr Val Cys Asp Val Glu Gly Cys Thr Trp Lys 
1               5                   10                  15      


Phe Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Lys Arg His 
            20                  25                  30  


<210>  752
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  752

Pro Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys Gly Arg Gly Phe Arg 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Arg Thr His 
            20                  25              


<210>  753
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  753

Pro Gly Glu Lys Pro Tyr Val Cys Ser Lys Cys Gly Lys Ala Phe Thr 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Gln Lys Ile His 
            20                  25              


<210>  754
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (19)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  754

Pro Gly Glu Arg Pro Phe Met Cys Thr Trp Ser Tyr Cys Gly Lys Arg 
1               5                   10                  15      


Phe Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Lys Arg Thr His 
            20                  25                  30  


<210>  755
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  755

Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Lys Lys Phe Ala 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Thr Lys Ile His 
            20                  25              


<210>  756
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  756

Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile Cys Gly Lys Lys Phe Ala 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Thr Lys Ile His 
            20                  25              


<210>  757
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  757

Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Ile Arg Thr His 
            20                  25              


<210>  758
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (18)..(24)
<223>  Xaa can be any naturally occurring amino acid

<400>  758

Thr Gly Ser Gln Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe 
1               5                   10                  15      


Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Ile Arg Thr His 
            20                  25                  


<210>  759
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  759

Val Pro Glu Arg Pro Phe Gln Cys Gln Ile Cys Met Arg Asn Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Ile Arg Thr His 
            20                  25              


<210>  760
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  760

Tyr Ala Cys His Leu Cys Ala Lys Ala Phe Ile Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Glu Lys Thr His 
            20              


<210>  761
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  761

Tyr Ala Cys His Leu Cys Gly Lys Ala Phe Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Glu Lys Thr His 
            20              


<210>  762
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  762

Tyr Glu Cys Asp His Cys Gly Lys Ala Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Arg Arg Ile His 
            20              


<210>  763
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  763

Tyr Glu Cys Asp His Cys Gly Lys Ser Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Lys Arg Thr His 
            20              


<210>  764
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  764

Tyr Glu Cys Asp Val Cys Gly Lys Thr Phe Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  765
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  765

Tyr Glu Cys Glu Lys Cys Gly Lys Ala Phe Asn Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Lys Lys Ser His 
            20              


<210>  766
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  766

Tyr Glu Cys His Asp Cys Gly Lys Ser Phe Arg Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Arg Arg Ile His 
            20              


<210>  767
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  767

Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Ile His 
            20              


<210>  768
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  768

Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Ala Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Ile His 
            20              


<210>  769
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  769

Tyr Glu Cys Asn Glu Cys Gly Lys Phe Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Arg Arg Ser His 
            20              


<210>  770
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  770

Tyr Glu Cys Asn Thr Cys Arg Lys Thr Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  771
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  771

Tyr Glu Cys Gln Asp Cys Gly Arg Ala Phe Asn Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Lys Arg Thr His 
            20              


<210>  772
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  772

Tyr Glu Cys Val Gln Cys Gly Lys Gly Phe Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Val His 
            20              


<210>  773
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  773

Tyr Glu Cys Val Gln Cys Gly Lys Ser Tyr Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Arg His 
            20              


<210>  774
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  774

Tyr Gly Cys His Leu Cys Gly Lys Ala Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Glu Met Ile His 
            20              


<210>  775
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  775

Tyr His Cys Asp Trp Asp Gly Cys Gly Trp Lys Phe Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Tyr Arg Lys His 
            20                  25  


<210>  776
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  776

Tyr Ile Cys Arg Lys Cys Gly Arg Gly Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  777
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  777

Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Lys Arg Ile His 
            20              


<210>  778
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  778

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Lys Ile Val His 
            20              


<210>  779
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  779

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Arg Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Lys Ile Ile His 
            20              


<210>  780
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  780

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Lys Lys Ile His 
            20              


<210>  781
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  781

Tyr Lys Cys Gly Gln Cys Gly Lys Phe Tyr Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Lys Ile His 
            20              


<210>  782
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  782

Tyr Lys Cys His Gln Cys Gly Lys Ala Phe Ile Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Glu Arg Thr His 
            20              


<210>  783
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  783

Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Asn Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His His Arg Ile His 
            20              


<210>  784
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  784

Tyr Lys Cys Lys Glu Cys Gly Gln Ala Phe Arg Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His His Lys Leu His 
            20              


<210>  785
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  785

Tyr Lys Cys Lys Gln Cys Gly Lys Ala Phe Gly Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gly Arg Thr His 
            20              


<210>  786
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  786

Tyr Lys Cys Met Glu Cys Gly Lys Ala Phe Asn Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Ile His 
            20              


<210>  787
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  787

Tyr Lys Cys Pro Asp Cys Gly Lys Ser Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  788
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  788

Tyr Met Cys Ser Glu Cys Gly Arg Gly Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  789
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  789

Tyr Gln Cys Asn Ile Cys Gly Lys Cys Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  790
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  790

Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe Arg Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Lys Arg Ile His 
            20              


<210>  791
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  791

Tyr Arg Cys Lys Tyr Cys Asp Arg Ser Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Val Arg Asn Ile His 
            20                  


<210>  792
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  792

Tyr Arg Cys Ser Trp Glu Gly Cys Glu Trp Arg Phe Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Phe Arg Lys His 
            20                  25  


<210>  793
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  793

Tyr Ser Cys Gly Ile Cys Gly Lys Ser Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Cys Ile Leu His 
            20              


<210>  794
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  794

Tyr Thr Cys Lys Gln Cys Gly Lys Ala Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Glu Thr Thr His 
            20              


<210>  795
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  795

Tyr Thr Cys Ser Asp Cys Gly Lys Ala Phe Arg Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Arg Arg Thr His 
            20              


<210>  796
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  796

Tyr Thr Cys Ser Tyr Cys Gly Lys Ser Phe Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Thr Arg Ile His 
            20              


<210>  797
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (14)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  797

Tyr Val Cys Asp Val Glu Gly Cys Thr Trp Lys Phe Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa His Lys Lys Arg His 
            20                  25  


<210>  798
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  798

Tyr Val Cys Arg Glu Cys Gly Arg Gly Phe Arg Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Lys Arg Thr His 
            20              


<210>  799
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  799

Tyr Val Cys Arg Glu Cys Arg Arg Gly Phe Ser Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Arg Thr His 
            20              


<210>  800
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the conserved regions of the zinc finger protein with insert for 
       recognition helix


<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  800

Tyr Val Cys Ser Lys Cys Gly Lys Ala Phe Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa His Gln Lys Ile His 
            20              


<210>  801
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ablation recognition site

<400>  801
ggtcgatgtt cgcaacgtcg atcgtacgtg ca                                     32


<210>  802
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ablation recognition site

<400>  802
ggtcggcgac gcgaatcgtc gattggcgta c                                      31


<210>  803
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ablation recognition site

<400>  803
actattcgca cgccgtacga tagtcggcgc ga                                     32


<210>  804
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ablation recognition site

<400>  804
ggtcggcgac gcgtatcgat tggcgtac                                          28


<210>  805
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker spacer

<400>  805

Gly Thr Ser Gly Lys 
1               5   


<210>  806
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a 32 bp sequence for ablation recognition site

<400>  806
ggtcgatgtt cgcaacgtcg atcgtacgtg ca                                     32


<210>  807
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  a conserved sequence for zinc finger module


<220>
<221>  misc_feature
<222>  (17)..(23)
<223>  Xaa can be any naturally occurring amino acid

<400>  807

Thr Gly Glu Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Leu Arg Thr His 
            20                  25              


<210>  808
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified FokI_Cat enzyme


<220>
<221>  CDS
<222>  (1)..(1443)

<220>
<221>  misc_feature
<222>  (1)..(594)
<223>  FokI catalytic domain

<220>
<221>  misc_feature
<222>  (595)..(606)
<223>  4 amino acid linker

<220>
<221>  misc_feature
<222>  (607)..(687)
<223>  zinc finger N1

<220>
<221>  misc_feature
<222>  (688)..(771)
<223>  zinc finger N2

<220>
<221>  misc_feature
<222>  (772)..(855)
<223>  zinc finger N3

<220>
<221>  misc_feature
<222>  (856)..(939)
<223>  zinc finger N4

<220>
<221>  misc_feature
<222>  (940)..(1023)
<223>  zinc finger N5

<220>
<221>  misc_feature
<222>  (1024)..(1107)
<223>  zinc finger N6

<220>
<221>  misc_feature
<222>  (1108)..(1191)
<223>  zinc finger N7

<220>
<221>  misc_feature
<222>  (1192)..(1275)
<223>  zinc finger N8

<220>
<221>  misc_feature
<222>  (1276)..(1359)
<223>  zinc finger N9

<220>
<221>  misc_feature
<222>  (1360)..(1443)
<223>  zinc finger N10

<400>  808
atg aag cag ctg gtg aaa agc gag ctg gaa gag aag aag tcc gag ctg         48
Met Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu           
1               5                   10                  15                

cgg cac aag ctg aaa tac gtg ccc cac gag tac atc gag ctg atc gag         96
Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu           
            20                  25                  30                    

atc gcc cgg aac ccc acc cag gac aga atc ctg gaa atg aag gtc atg        144
Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met           
        35                  40                  45                        

gaa ttt ttc atg aag gtg tac ggc tac cgg ggc gag cac ctg ggc ggc        192
Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly           
    50                  55                  60                            

agc aga aaa ccc gac ggc gcc atc tac acc gtg ggc agc ccc atc gac        240
Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp           
65                  70                  75                  80            

tac ggc gtg atc gtg gac acc aag gcc tac agc ggc ggc tac aac ctg        288
Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu           
                85                  90                  95                

ccc atc gga cag gcc gac gag atg cag aga tac gtg gaa gag aac cag        336
Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln           
            100                 105                 110                   

acc cgg aac aag cac atc aac ccc aac gag tgg tgg aag gtg tac ccc        384
Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro           
        115                 120                 125                       

agc agc gtg acc gag ttc aag ttc ctg ttc gtg tcc ggc cac ttc aag        432
Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys           
    130                 135                 140                           

ggc aac tac aag gcc cag ctg acc cgg ctg aac cac atc acc aac tgc        480
Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys           
145                 150                 155                 160           

aac ggc gct gtg ctg agc gtg gaa gaa ctg ctg atc ggc ggc gag atg        528
Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met           
                165                 170                 175               

atc aag gcc ggc acc ctg acc ctg gaa gaa gtg cgg cgg aag ttc aac        576
Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn           
            180                 185                 190                   

aac ggc gag atc aac ttc ggc act agt ggc ggc gag aag ccc tac aag        624
Asn Gly Glu Ile Asn Phe Gly Thr Ser Gly Gly Glu Lys Pro Tyr Lys           
        195                 200                 205                       

tgc cct gag tgc ggc aag agc ttc agc cag aga aga agc ctg ggc cac        672
Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Arg Arg Ser Leu Gly His           
    210                 215                 220                           

cac cag cgt acg cac ccc ggc gag aaa cct tat aag tgt ccc gaa tgt        720
His Gln Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys           
225                 230                 235                 240           

ggc aag tcc ttc agc aag aag aac gac ctg acc cgg cac cag cgg aca        768
Gly Lys Ser Phe Ser Lys Lys Asn Asp Leu Thr Arg His Gln Arg Thr           
                245                 250                 255               

cac ccc ggg gaa aag cca tac aaa tgt cca gag tgt ggg aag tct ttc        816
His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe           
            260                 265                 270                   

tcc agc cgg cgg acc tgc aga gcc cat cag aga aca cat acc ggg gag        864
Ser Ser Arg Arg Thr Cys Arg Ala His Gln Arg Thr His Thr Gly Glu           
        275                 280                 285                       

aag cct ttc cag tgc cgg atc tgc atg aga aac ttc agc gtg cgg cac        912
Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Val Arg His           
    290                 295                 300                           

aac ctg acc aga cac ctg agg acc cat acc ggc gaa aaa ccc ttt cag        960
Asn Leu Thr Arg His Leu Arg Thr His Thr Gly Glu Lys Pro Phe Gln           
305                 310                 315                 320           

tgc aga atc tgt atg cgg aac ttc tcc gac cgg acc agc ctg gcc cgg       1008
Cys Arg Ile Cys Met Arg Asn Phe Ser Asp Arg Thr Ser Leu Ala Arg           
                325                 330                 335               

cat ctg aga act cat cct ggg gaa aag ccc tat aag tgt cca gaa tgc       1056
His Leu Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys           
            340                 345                 350                   

ggg aaa tcc ttt agc gac agc ggc aac ctg cgg gtg cac cag agg act       1104
Gly Lys Ser Phe Ser Asp Ser Gly Asn Leu Arg Val His Gln Arg Thr           
        355                 360                 365                       

cat cca ggc gag aaa ccc tac aaa tgc ccc gaa tgc gga aag tca ttc       1152
His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe           
    370                 375                 380                           

tcc cac acc ggc cat ctg ctc gag cat cag cgg acc cac act ggg gag       1200
Ser His Thr Gly His Leu Leu Glu His Gln Arg Thr His Thr Gly Glu           
385                 390                 395                 400           

aaa cca ttt cag tgt cgc atc tgt atg agg aat ttc agc acc aac cag       1248
Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Thr Asn Gln           
                405                 410                 415               

gcc ctg ggc gtg cac ctg aga aca cac cca ggc gag aag cct tac aag       1296
Ala Leu Gly Val His Leu Arg Thr His Pro Gly Glu Lys Pro Tyr Lys           
            420                 425                 430                   

tgt cca gag tgc gga aag tca ttt tcc gtg cgc cac aat ctg aca cgg       1344
Cys Pro Glu Cys Gly Lys Ser Phe Ser Val Arg His Asn Leu Thr Arg           
        435                 440                 445                       

cat cag cgc acc cat ccc ggc gag aag cct tac aaa tgc ccc gag tgt       1392
His Gln Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys           
    450                 455                 460                           

ggc aaa tct ttc agt gac cgg acc tct ctg gcc aga cat cag agg aca       1440
Gly Lys Ser Phe Ser Asp Arg Thr Ser Leu Ala Arg His Gln Arg Thr           
465                 470                 475                 480           

cac                                                                   1443
His                                                                       
                                                                          


<210>  809
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  809

Met Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
1               5                   10                  15      


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
            20                  25                  30          


Ile Ala Arg Asn Pro Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
        35                  40                  45              


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Glu His Leu Gly Gly 
    50                  55                  60                  


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
65                  70                  75                  80  


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
                85                  90                  95      


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
            100                 105                 110         


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
        115                 120                 125             


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
    130                 135                 140                 


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
145                 150                 155                 160 


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
                165                 170                 175     


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
            180                 185                 190         


Asn Gly Glu Ile Asn Phe Gly Thr Ser Gly Gly Glu Lys Pro Tyr Lys 
        195                 200                 205             


Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Arg Arg Ser Leu Gly His 
    210                 215                 220                 


His Gln Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys 
225                 230                 235                 240 


Gly Lys Ser Phe Ser Lys Lys Asn Asp Leu Thr Arg His Gln Arg Thr 
                245                 250                 255     


His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe 
            260                 265                 270         


Ser Ser Arg Arg Thr Cys Arg Ala His Gln Arg Thr His Thr Gly Glu 
        275                 280                 285             


Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Val Arg His 
    290                 295                 300                 


Asn Leu Thr Arg His Leu Arg Thr His Thr Gly Glu Lys Pro Phe Gln 
305                 310                 315                 320 


Cys Arg Ile Cys Met Arg Asn Phe Ser Asp Arg Thr Ser Leu Ala Arg 
                325                 330                 335     


His Leu Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys 
            340                 345                 350         


Gly Lys Ser Phe Ser Asp Ser Gly Asn Leu Arg Val His Gln Arg Thr 
        355                 360                 365             


His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe 
    370                 375                 380                 


Ser His Thr Gly His Leu Leu Glu His Gln Arg Thr His Thr Gly Glu 
385                 390                 395                 400 


Lys Pro Phe Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Thr Asn Gln 
                405                 410                 415     


Ala Leu Gly Val His Leu Arg Thr His Pro Gly Glu Lys Pro Tyr Lys 
            420                 425                 430         


Cys Pro Glu Cys Gly Lys Ser Phe Ser Val Arg His Asn Leu Thr Arg 
        435                 440                 445             


His Gln Arg Thr His Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys 
    450                 455                 460                 


Gly Lys Ser Phe Ser Asp Arg Thr Ser Leu Ala Arg His Gln Arg Thr 
465                 470                 475                 480 


His 
    


<210>  810
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid reporter gene expression


<220>
<221>  misc_feature
<222>  (1)..(832)
<223>  CMV I.E. enhancer and promoter

<220>
<221>  misc_feature
<222>  (833)..(1029)
<223>  Promega intron

<220>
<221>  misc_feature
<222>  (1077)..(1082)
<223>  Kozak sequence

<220>
<221>  misc_feature
<222>  (1083)..(2732)
<223>  Luciferase

<220>
<221>  misc_feature
<222>  (2752)..(2991)
<223>  SV40 polyA

<400>  810
taggaagatc ttcaatattg gccattagcc atattattca ttggttatat agcataaatc       60

aatattggct attggccatt gcatacgttg tatctatatc ataatatgta catttatatt      120

ggctcatgtc caatatgacc gccatgttgg cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      780

cacagttaaa ttgctaacgc agtcagtgct tctgacacaa cagtctcgaa cttaagctgc      840

agaagttggt cgtgaggcac tgggcaggta agtatcaagg ttacaagaca ggtttaagga      900

gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg ataggcacct      960

attggtctta ctgacatcca ctttgccttt ctctccacag gtgtccactc ccagttcaat     1020

tacagctctt aaggctagag tacttaatac gactcactat aggctagcgc gatcgcgcca     1080

ccatggaaga tgccaaaaac attaagaagg gcccagcgcc attctaccca ctcgaagacg     1140

ggaccgccgg cgagcagctg cacaaagcca tgaagcgcta cgccctggtg cccggcacca     1200

tcgcctttac cgacgcacat atcgaggtgg acattaccta cgccgagtac ttcgagatga     1260

gcgttcggct ggcagaagct atgaagcgct atgggctgaa tacaaaccat cggatcgtgg     1320

tgtgcagcga gaatagcttg cagttcttca tgcccgtgtt gggtgccctg ttcatcggtg     1380

tggctgtggc cccagctaac gacatctaca acgagcgcga gctgctgaac agcatgggca     1440

tcagccagcc caccgtcgta ttcgtgagca agaaagggct gcaaaagatc ctcaacgtgc     1500

aaaagaagct accgatcata caaaagatca tcatcatgga tagcaagacc gactaccagg     1560

gcttccaaag catgtacacc ttcgtgactt cccatttgcc acccggcttc aacgagtacg     1620

acttcgtgcc cgagagcttc gaccgggaca aaaccatcgc cctgatcatg aacagtagtg     1680

gcagtaccgg attgcccaag ggcgtagccc taccgcaccg caccgcttgt gtccgattca     1740

gtcatgcccg cgaccccatc ttcggcaacc agatcatccc cgacaccgct atcctcagcg     1800

tggtgccatt tcaccacggc ttcggcatgt tcaccacgct gggctacttg atctgcggct     1860

ttcgggtcgt gctcatgtac cgcttcgagg aggagctatt cttgcgcagc ttgcaagact     1920

ataagattca atctgccctg ctggtgccca cactatttag cttcttcgct aagagcactc     1980

tcatcgacaa gtacgaccta agcaacttgc acgagatcgc cagcggcggg gcgccgctca     2040

gcaaggaggt aggtgaggcc gtggccaaac gcttccacct accaggcatc cgccagggct     2100

acggcctgac agaaacaacc agcgccattc tgatcacccc cgaaggggac gacaagcctg     2160

gcgcagtagg caaggtggtg cccttcttcg aggctaaggt ggtggacttg gacaccggta     2220

agacactggg tgtgaaccag cgcggcgagc tgtgcgtccg tggccccatg atcatgagcg     2280

gctacgttaa caaccccgag gctacaaacg ctctcatcga caaggacggc tggctgcaca     2340

gcggcgacat cgcctactgg gacgaggacg agcacttctt catcgtggac cggctgaaga     2400

gcctgatcaa atacaagggc taccaggtag ccccagccga actggagagc atcctgctgc     2460

aacaccccaa catcttcgac gccggggtcg ccggcctgcc cgacgacgat gccggcgagc     2520

tgcccgccgc agtcgtcgtg ctggaacacg gtaaaaccat gaccgagaag gagatcgtgg     2580

actatgtggc cagccaggtt acaaccgcca agaagctgcg cggtggtgtt gtgttcgtgg     2640

acgaggtgcc taaaggactg accggcaagt tggacgcccg caagatccgc gagattctca     2700

ttaaggccaa gaagggcggc aagatcgccg tgtaataagc atgcaagctt gcggccgctt     2760

cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga     2820

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     2880

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag     2940

atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat c              2991


<210>  811
<211>  3061
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid reporter gene expression


<220>
<221>  misc_feature
<222>  (1)..(832)
<223>  CMV I.E. enhancer and promoter

<220>
<221>  misc_feature
<222>  (833)..(1029)
<223>  Promega intron

<220>
<221>  misc_feature
<222>  (1069)..(1100)
<223>  32 bp sequence in direct orientation

<220>
<221>  misc_feature
<222>  (1101)..(1106)
<223>  spacer

<220>
<221>  misc_feature
<222>  (1107)..(1138)
<223>  32 pb sequence in inverted orientation

<220>
<221>  misc_feature
<222>  (1147)..(1152)
<223>  Kozak sequence

<220>
<221>  misc_feature
<222>  (1153)..(2802)
<223>  Luciferase

<220>
<221>  misc_feature
<222>  (2822)..(3061)
<223>  SV40 polyA

<400>  811
taggaagatc ttcaatattg gccattagcc atattattca ttggttatat agcataaatc       60

aatattggct attggccatt gcatacgttg tatctatatc ataatatgta catttatatt      120

ggctcatgtc caatatgacc gccatgttgg cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      780

cacagttaaa ttgctaacgc agtcagtgct tctgacacaa cagtctcgaa cttaagctgc      840

agaagttggt cgtgaggcac tgggcaggta agtatcaagg ttacaagaca ggtttaagga      900

gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg ataggcacct      960

attggtctta ctgacatcca ctttgccttt ctctccacag gtgtccactc ccagttcaat     1020

tacagctctt aaggctagag tacttaatac gactcactat aggctagcgg tcgatgttcg     1080

caacgtcgat cgtacgtgca acgcgttgca cgtacgatcg acgttgcgaa catcgaccgc     1140

gatcgcgcca ccatggaaga tgccaaaaac attaagaagg gcccagcgcc attctaccca     1200

ctcgaagacg ggaccgccgg cgagcagctg cacaaagcca tgaagcgcta cgccctggtg     1260

cccggcacca tcgcctttac cgacgcacat atcgaggtgg acattaccta cgccgagtac     1320

ttcgagatga gcgttcggct ggcagaagct atgaagcgct atgggctgaa tacaaaccat     1380

cggatcgtgg tgtgcagcga gaatagcttg cagttcttca tgcccgtgtt gggtgccctg     1440

ttcatcggtg tggctgtggc cccagctaac gacatctaca acgagcgcga gctgctgaac     1500

agcatgggca tcagccagcc caccgtcgta ttcgtgagca agaaagggct gcaaaagatc     1560

ctcaacgtgc aaaagaagct accgatcata caaaagatca tcatcatgga tagcaagacc     1620

gactaccagg gcttccaaag catgtacacc ttcgtgactt cccatttgcc acccggcttc     1680

aacgagtacg acttcgtgcc cgagagcttc gaccgggaca aaaccatcgc cctgatcatg     1740

aacagtagtg gcagtaccgg attgcccaag ggcgtagccc taccgcaccg caccgcttgt     1800

gtccgattca gtcatgcccg cgaccccatc ttcggcaacc agatcatccc cgacaccgct     1860

atcctcagcg tggtgccatt tcaccacggc ttcggcatgt tcaccacgct gggctacttg     1920

atctgcggct ttcgggtcgt gctcatgtac cgcttcgagg aggagctatt cttgcgcagc     1980

ttgcaagact ataagattca atctgccctg ctggtgccca cactatttag cttcttcgct     2040

aagagcactc tcatcgacaa gtacgaccta agcaacttgc acgagatcgc cagcggcggg     2100

gcgccgctca gcaaggaggt aggtgaggcc gtggccaaac gcttccacct accaggcatc     2160

cgccagggct acggcctgac agaaacaacc agcgccattc tgatcacccc cgaaggggac     2220

gacaagcctg gcgcagtagg caaggtggtg cccttcttcg aggctaaggt ggtggacttg     2280

gacaccggta agacactggg tgtgaaccag cgcggcgagc tgtgcgtccg tggccccatg     2340

atcatgagcg gctacgttaa caaccccgag gctacaaacg ctctcatcga caaggacggc     2400

tggctgcaca gcggcgacat cgcctactgg gacgaggacg agcacttctt catcgtggac     2460

cggctgaaga gcctgatcaa atacaagggc taccaggtag ccccagccga actggagagc     2520

atcctgctgc aacaccccaa catcttcgac gccggggtcg ccggcctgcc cgacgacgat     2580

gccggcgagc tgcccgccgc agtcgtcgtg ctggaacacg gtaaaaccat gaccgagaag     2640

gagatcgtgg actatgtggc cagccaggtt acaaccgcca agaagctgcg cggtggtgtt     2700

gtgttcgtgg acgaggtgcc taaaggactg accggcaagt tggacgcccg caagatccgc     2760

gagattctca ttaaggccaa gaagggcggc aagatcgccg tgtaataagc atgcaagctt     2820

gcggccgctt cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag     2880

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac     2940

cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt     3000

tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat     3060

c                                                                     3061


<210>  812
<211>  3131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid reporter gene expression


<220>
<221>  misc_feature
<222>  (1)..(832)
<223>  CMV I.E. enhancer and promoter

<220>
<221>  misc_feature
<222>  (833)..(1029)
<223>  Promega intron

<220>
<221>  misc_feature
<222>  (1069)..(1100)
<223>  32 bp sequence in direct orientation

<220>
<221>  misc_feature
<222>  (1101)..(1106)
<223>  spacer

<220>
<221>  misc_feature
<222>  (1107)..(1138)
<223>  32 bp sequence in inverted orientation

<220>
<221>  misc_feature
<222>  (1147)..(1152)
<223>  Kozak sequence

<220>
<221>  misc_feature
<222>  (1153)..(2802)
<223>  Luciferase

<220>
<221>  misc_feature
<222>  (2815)..(2846)
<223>  32 bp sequence in direct orientation

<220>
<221>  misc_feature
<222>  (2847)..(2852)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2853)..(2884)
<223>  32 bp sequence in inverted orientation

<220>
<221>  misc_feature
<222>  (2893)..(3131)
<223>  SV40 polyA

<400>  812
taggaagatc ttcaatattg gccattagcc atattattca ttggttatat agcataaatc       60

aatattggct attggccatt gcatacgttg tatctatatc ataatatgta catttatatt      120

ggctcatgtc caatatgacc gccatgttgg cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      780

cacagttaaa ttgctaacgc agtcagtgct tctgacacaa cagtctcgaa cttaagctgc      840

agaagttggt cgtgaggcac tgggcaggta agtatcaagg ttacaagaca ggtttaagga      900

gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg ataggcacct      960

attggtctta ctgacatcca ctttgccttt ctctccacag gtgtccactc ccagttcaat     1020

tacagctctt aaggctagag tacttaatac gactcactat aggctagcgg tcgatgttcg     1080

caacgtcgat cgtacgtgca acgcgttgca cgtacgatcg acgttgcgaa catcgaccgc     1140

gatcgcgcca ccatggaaga tgccaaaaac attaagaagg gcccagcgcc attctaccca     1200

ctcgaagacg ggaccgccgg cgagcagctg cacaaagcca tgaagcgcta cgccctggtg     1260

cccggcacca tcgcctttac cgacgcacat atcgaggtgg acattaccta cgccgagtac     1320

ttcgagatga gcgttcggct ggcagaagct atgaagcgct atgggctgaa tacaaaccat     1380

cggatcgtgg tgtgcagcga gaatagcttg cagttcttca tgcccgtgtt gggtgccctg     1440

ttcatcggtg tggctgtggc cccagctaac gacatctaca acgagcgcga gctgctgaac     1500

agcatgggca tcagccagcc caccgtcgta ttcgtgagca agaaagggct gcaaaagatc     1560

ctcaacgtgc aaaagaagct accgatcata caaaagatca tcatcatgga tagcaagacc     1620

gactaccagg gcttccaaag catgtacacc ttcgtgactt cccatttgcc acccggcttc     1680

aacgagtacg acttcgtgcc cgagagcttc gaccgggaca aaaccatcgc cctgatcatg     1740

aacagtagtg gcagtaccgg attgcccaag ggcgtagccc taccgcaccg caccgcttgt     1800

gtccgattca gtcatgcccg cgaccccatc ttcggcaacc agatcatccc cgacaccgct     1860

atcctcagcg tggtgccatt tcaccacggc ttcggcatgt tcaccacgct gggctacttg     1920

atctgcggct ttcgggtcgt gctcatgtac cgcttcgagg aggagctatt cttgcgcagc     1980

ttgcaagact ataagattca atctgccctg ctggtgccca cactatttag cttcttcgct     2040

aagagcactc tcatcgacaa gtacgaccta agcaacttgc acgagatcgc cagcggcggg     2100

gcgccgctca gcaaggaggt aggtgaggcc gtggccaaac gcttccacct accaggcatc     2160

cgccagggct acggcctgac agaaacaacc agcgccattc tgatcacccc cgaaggggac     2220

gacaagcctg gcgcagtagg caaggtggtg cccttcttcg aggctaaggt ggtggacttg     2280

gacaccggta agacactggg tgtgaaccag cgcggcgagc tgtgcgtccg tggccccatg     2340

atcatgagcg gctacgttaa caaccccgag gctacaaacg ctctcatcga caaggacggc     2400

tggctgcaca gcggcgacat cgcctactgg gacgaggacg agcacttctt catcgtggac     2460

cggctgaaga gcctgatcaa atacaagggc taccaggtag ccccagccga actggagagc     2520

atcctgctgc aacaccccaa catcttcgac gccggggtcg ccggcctgcc cgacgacgat     2580

gccggcgagc tgcccgccgc agtcgtcgtg ctggaacacg gtaaaaccat gaccgagaag     2640

gagatcgtgg actatgtggc cagccaggtt acaaccgcca agaagctgcg cggtggtgtt     2700

gtgttcgtgg acgaggtgcc taaaggactg accggcaagt tggacgcccg caagatccgc     2760

gagattctca ttaaggccaa gaagggcggc aagatcgccg tgtaataagc atgcggtcga     2820

tgttcgcaac gtcgatcgta cgtgcaacgc gttgcacgta cgatcgacgt tgcgaacatc     2880

gaccaagctt gcggccgctt cgagcagaca tgataagata cattgatgag tttggacaaa     2940

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     3000

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     3060

tgtttcaggt tcagggggag atgtgggagg ttttttaaag caagtaaaac ctctacaaat     3120

gtggtaaaat c                                                          3131


<210>  813
<211>  3029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid reporter gene expression


<220>
<221>  misc_feature
<222>  (1)..(832)
<223>  CMV I.E. enhancer and promoter

<220>
<221>  misc_feature
<222>  (833)..(1029)
<223>  Promega intron

<220>
<221>  misc_feature
<222>  (1069)..(1100)
<223>  32 bp sequence in direct orientation

<220>
<221>  misc_feature
<222>  (1115)..(1120)
<223>  Kozak sequence

<220>
<221>  misc_feature
<222>  (1121)..(2770)
<223>  Luciferase

<220>
<221>  misc_feature
<222>  (2791)..(3029)
<223>  SV40 polyA

<400>  813
taggaagatc ttcaatattg gccattagcc atattattca ttggttatat agcataaatc       60

aatattggct attggccatt gcatacgttg tatctatatc ataatatgta catttatatt      120

ggctcatgtc caatatgacc gccatgttgg cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      780

cacagttaaa ttgctaacgc agtcagtgct tctgacacaa cagtctcgaa cttaagctgc      840

agaagttggt cgtgaggcac tgggcaggta agtatcaagg ttacaagaca ggtttaagga      900

gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg ataggcacct      960

attggtctta ctgacatcca ctttgccttt ctctccacag gtgtccactc ccagttcaat     1020

tacagctctt aaggctagag tacttaatac gactcactat aggctagcgg tcgatgttcg     1080

caacgtcgat cgtacgtgca acgcgtgcga tcgcgccacc atggaagatg ccaaaaacat     1140

taagaagggc ccagcgccat tctacccact cgaagacggg accgccggcg agcagctgca     1200

caaagccatg aagcgctacg ccctggtgcc cggcaccatc gcctttaccg acgcacatat     1260

cgaggtggac attacctacg ccgagtactt cgagatgagc gttcggctgg cagaagctat     1320

gaagcgctat gggctgaata caaaccatcg gatcgtggtg tgcagcgaga atagcttgca     1380

gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg gctgtggccc cagctaacga     1440

catctacaac gagcgcgagc tgctgaacag catgggcatc agccagccca ccgtcgtatt     1500

cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa aagaagctac cgatcataca     1560

aaagatcatc atcatggata gcaagaccga ctaccagggc ttccaaagca tgtacacctt     1620

cgtgacttcc catttgccac ccggcttcaa cgagtacgac ttcgtgcccg agagcttcga     1680

ccgggacaaa accatcgccc tgatcatgaa cagtagtggc agtaccggat tgcccaaggg     1740

cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt catgcccgcg accccatctt     1800

cggcaaccag atcatccccg acaccgctat cctcagcgtg gtgccatttc accacggctt     1860

cggcatgttc accacgctgg gctacttgat ctgcggcttt cgggtcgtgc tcatgtaccg     1920

cttcgaggag gagctattct tgcgcagctt gcaagactat aagattcaat ctgccctgct     1980

ggtgcccaca ctatttagct tcttcgctaa gagcactctc atcgacaagt acgacctaag     2040

caacttgcac gagatcgcca gcggcggggc gccgctcagc aaggaggtag gtgaggccgt     2100

ggccaaacgc ttccacctac caggcatccg ccagggctac ggcctgacag aaacaaccag     2160

cgccattctg atcacccccg aaggggacga caagcctggc gcagtaggca aggtggtgcc     2220

cttcttcgag gctaaggtgg tggacttgga caccggtaag acactgggtg tgaaccagcg     2280

cggcgagctg tgcgtccgtg gccccatgat catgagcggc tacgttaaca accccgaggc     2340

tacaaacgct ctcatcgaca aggacggctg gctgcacagc ggcgacatcg cctactggga     2400

cgaggacgag cacttcttca tcgtggaccg gctgaagagc ctgatcaaat acaagggcta     2460

ccaggtagcc ccagccgaac tggagagcat cctgctgcaa caccccaaca tcttcgacgc     2520

cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg cccgccgcag tcgtcgtgct     2580

ggaacacggt aaaaccatga ccgagaagga gatcgtggac tatgtggcca gccaggttac     2640

aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac gaggtgccta aaggactgac     2700

cggcaagttg gacgcccgca agatccgcga gattctcatt aaggccaaga agggcggcaa     2760

gatcgccgtg taataagcat gcaagcttgc ggccgcttcg agcagacatg ataagataca     2820

ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa     2880

tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca     2940

acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt ttttaaagca     3000

agtaaaacct ctacaaatgt ggtaaaatc                                       3029


<210>  814
<211>  3067
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid reporter gene expression


<220>
<221>  misc_feature
<222>  (1)..(832)
<223>  CMV I.E. enhancer and promoter

<220>
<221>  misc_feature
<222>  (833)..(1029)
<223>  Promega intron

<220>
<221>  misc_feature
<222>  (1069)..(1100)
<223>  32 bp sequence in direct orientation

<220>
<221>  misc_feature
<222>  (1115)..(1120)
<223>  Kozak sequence

<220>
<221>  misc_feature
<222>  (1121)..(2770)
<223>  Luciferase

<220>
<221>  misc_feature
<222>  (2783)..(2814)
<223>  32 bp sequence in direct orientation

<220>
<221>  misc_feature
<222>  (2829)..(3067)
<223>  SV40 polyA

<400>  814
taggaagatc ttcaatattg gccattagcc atattattca ttggttatat agcataaatc       60

aatattggct attggccatt gcatacgttg tatctatatc ataatatgta catttatatt      120

ggctcatgtc caatatgacc gccatgttgg cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      780

cacagttaaa ttgctaacgc agtcagtgct tctgacacaa cagtctcgaa cttaagctgc      840

agaagttggt cgtgaggcac tgggcaggta agtatcaagg ttacaagaca ggtttaagga      900

gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg ataggcacct      960

attggtctta ctgacatcca ctttgccttt ctctccacag gtgtccactc ccagttcaat     1020

tacagctctt aaggctagag tacttaatac gactcactat aggctagcgg tcgatgttcg     1080

caacgtcgat cgtacgtgca acgcgtgcga tcgcgccacc atggaagatg ccaaaaacat     1140

taagaagggc ccagcgccat tctacccact cgaagacggg accgccggcg agcagctgca     1200

caaagccatg aagcgctacg ccctggtgcc cggcaccatc gcctttaccg acgcacatat     1260

cgaggtggac attacctacg ccgagtactt cgagatgagc gttcggctgg cagaagctat     1320

gaagcgctat gggctgaata caaaccatcg gatcgtggtg tgcagcgaga atagcttgca     1380

gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg gctgtggccc cagctaacga     1440

catctacaac gagcgcgagc tgctgaacag catgggcatc agccagccca ccgtcgtatt     1500

cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa aagaagctac cgatcataca     1560

aaagatcatc atcatggata gcaagaccga ctaccagggc ttccaaagca tgtacacctt     1620

cgtgacttcc catttgccac ccggcttcaa cgagtacgac ttcgtgcccg agagcttcga     1680

ccgggacaaa accatcgccc tgatcatgaa cagtagtggc agtaccggat tgcccaaggg     1740

cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt catgcccgcg accccatctt     1800

cggcaaccag atcatccccg acaccgctat cctcagcgtg gtgccatttc accacggctt     1860

cggcatgttc accacgctgg gctacttgat ctgcggcttt cgggtcgtgc tcatgtaccg     1920

cttcgaggag gagctattct tgcgcagctt gcaagactat aagattcaat ctgccctgct     1980

ggtgcccaca ctatttagct tcttcgctaa gagcactctc atcgacaagt acgacctaag     2040

caacttgcac gagatcgcca gcggcggggc gccgctcagc aaggaggtag gtgaggccgt     2100

ggccaaacgc ttccacctac caggcatccg ccagggctac ggcctgacag aaacaaccag     2160

cgccattctg atcacccccg aaggggacga caagcctggc gcagtaggca aggtggtgcc     2220

cttcttcgag gctaaggtgg tggacttgga caccggtaag acactgggtg tgaaccagcg     2280

cggcgagctg tgcgtccgtg gccccatgat catgagcggc tacgttaaca accccgaggc     2340

tacaaacgct ctcatcgaca aggacggctg gctgcacagc ggcgacatcg cctactggga     2400

cgaggacgag cacttcttca tcgtggaccg gctgaagagc ctgatcaaat acaagggcta     2460

ccaggtagcc ccagccgaac tggagagcat cctgctgcaa caccccaaca tcttcgacgc     2520

cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg cccgccgcag tcgtcgtgct     2580

ggaacacggt aaaaccatga ccgagaagga gatcgtggac tatgtggcca gccaggttac     2640

aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac gaggtgccta aaggactgac     2700

cggcaagttg gacgcccgca agatccgcga gattctcatt aaggccaaga agggcggcaa     2760

gatcgccgtg taataagcat gcggtcgatg ttcgcaacgt cgatcgtacg tgcaacgcgt     2820

aagcttgcgg ccgcttcgag cagacatgat aagatacatt gatgagtttg gacaaaccac     2880

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt     2940

tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt     3000

tcaggttcag ggggagatgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg     3060

taaaatc                                                               3067


<210>  815
<211>  3067
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid reporter gene expression


<220>
<221>  misc_feature
<222>  (1)..(832)
<223>  CMV I.E. enhancer and promoter

<220>
<221>  misc_feature
<222>  (833)..(1029)
<223>  Promega intron

<220>
<221>  misc_feature
<222>  (1069)..(1100)
<223>  32 bp sequence in direct orientation

<220>
<221>  misc_feature
<222>  (1115)..(1120)
<223>  Kozak sequence

<220>
<221>  misc_feature
<222>  (1121)..(2770)
<223>  Luciferase

<220>
<221>  misc_feature
<222>  (2789)..(2820)
<223>  32 bp sequence in direct orientation

<220>
<221>  misc_feature
<222>  (2829)..(3067)
<223>  SV40 polyA

<400>  815
taggaagatc ttcaatattg gccattagcc atattattca ttggttatat agcataaatc       60

aatattggct attggccatt gcatacgttg tatctatatc ataatatgta catttatatt      120

ggctcatgtc caatatgacc gccatgttgg cattgattat tgactagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      540

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      600

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      660

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      720

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      780

cacagttaaa ttgctaacgc agtcagtgct tctgacacaa cagtctcgaa cttaagctgc      840

agaagttggt cgtgaggcac tgggcaggta agtatcaagg ttacaagaca ggtttaagga      900

gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg ataggcacct      960

attggtctta ctgacatcca ctttgccttt ctctccacag gtgtccactc ccagttcaat     1020

tacagctctt aaggctagag tacttaatac gactcactat aggctagcgg tcgatgttcg     1080

caacgtcgat cgtacgtgca acgcgtgcga tcgcgccacc atggaagatg ccaaaaacat     1140

taagaagggc ccagcgccat tctacccact cgaagacggg accgccggcg agcagctgca     1200

caaagccatg aagcgctacg ccctggtgcc cggcaccatc gcctttaccg acgcacatat     1260

cgaggtggac attacctacg ccgagtactt cgagatgagc gttcggctgg cagaagctat     1320

gaagcgctat gggctgaata caaaccatcg gatcgtggtg tgcagcgaga atagcttgca     1380

gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg gctgtggccc cagctaacga     1440

catctacaac gagcgcgagc tgctgaacag catgggcatc agccagccca ccgtcgtatt     1500

cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa aagaagctac cgatcataca     1560

aaagatcatc atcatggata gcaagaccga ctaccagggc ttccaaagca tgtacacctt     1620

cgtgacttcc catttgccac ccggcttcaa cgagtacgac ttcgtgcccg agagcttcga     1680

ccgggacaaa accatcgccc tgatcatgaa cagtagtggc agtaccggat tgcccaaggg     1740

cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt catgcccgcg accccatctt     1800

cggcaaccag atcatccccg acaccgctat cctcagcgtg gtgccatttc accacggctt     1860

cggcatgttc accacgctgg gctacttgat ctgcggcttt cgggtcgtgc tcatgtaccg     1920

cttcgaggag gagctattct tgcgcagctt gcaagactat aagattcaat ctgccctgct     1980

ggtgcccaca ctatttagct tcttcgctaa gagcactctc atcgacaagt acgacctaag     2040

caacttgcac gagatcgcca gcggcggggc gccgctcagc aaggaggtag gtgaggccgt     2100

ggccaaacgc ttccacctac caggcatccg ccagggctac ggcctgacag aaacaaccag     2160

cgccattctg atcacccccg aaggggacga caagcctggc gcagtaggca aggtggtgcc     2220

cttcttcgag gctaaggtgg tggacttgga caccggtaag acactgggtg tgaaccagcg     2280

cggcgagctg tgcgtccgtg gccccatgat catgagcggc tacgttaaca accccgaggc     2340

tacaaacgct ctcatcgaca aggacggctg gctgcacagc ggcgacatcg cctactggga     2400

cgaggacgag cacttcttca tcgtggaccg gctgaagagc ctgatcaaat acaagggcta     2460

ccaggtagcc ccagccgaac tggagagcat cctgctgcaa caccccaaca tcttcgacgc     2520

cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg cccgccgcag tcgtcgtgct     2580

ggaacacggt aaaaccatga ccgagaagga gatcgtggac tatgtggcca gccaggttac     2640

aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac gaggtgccta aaggactgac     2700

cggcaagttg gacgcccgca agatccgcga gattctcatt aaggccaaga agggcggcaa     2760

gatcgccgtg taataagcat gcacgcgttg cacgtacgat cgacgttgcg aacatcgacc     2820

aagcttgcgg ccgcttcgag cagacatgat aagatacatt gatgagtttg gacaaaccac     2880

aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt     2940

tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt     3000

tcaggttcag ggggagatgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg     3060

taaaatc                                                               3067


<210>  816
<211>  550
<212>  PRT
<213>  Renilla reniformis

<400>  816

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val 
545                 550 


<210>  817
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ablation recognition site

<400>  817
ggtcggcgac gcgtaatcgt cgattggcgt ac                                     32


<210>  818
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified FokI enzyme

<400>  818

Met Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe 
1               5                   10                  15      


Ser Gln Arg Arg Ser Leu Gly His His Gln Arg Thr His 
            20                  25                  


