                         SEQUENCE LISTING

<110>  Dharmacon, Inc.
 
<120>  Optimization of Vectors for Effective Delivery and Expression of 
       Genetic Content

<130>  DHARMA 0077-PCT

<150>  US 61/543,596
<151>  2011-10-05

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  581
<212>  DNA
<213>  human cytomegalovirus

<400>  1
aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat       60

aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa      120

taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg      180

agtatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc      240

cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct      300

tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga      360

tgcggttttg gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa      420

gtctccaccc cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc      480

caaaatgtcg taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg      540

aggtctatat aagcagagct cgtttagtga accgtcagat c                          581


<210>  2
<211>  537
<212>  DNA
<213>  mouse cytomegalovirus

<400>  2
tggcacgtat actgagtcat tagggacttt ccaatgggtt ttgcccagta cataaggtca       60

ataggggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact      120

ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc      180

attattggca cgtacataag gtcaataggg gtgagtcatt gggtttttcc agccaattta      240

attaaaacgc catgtacttt cccaccattg acgtcaatgg gctattgaaa ctaatgcaac      300

gtgaccttta aacggtactt tcccatagct gattaatggg aaagtaccgt tctcagagcc      360

aatacacgtc aatgggaagt gaaagggcag ccaaaacgta acaccgcccc ggttttcccc      420

tggaaattcc atattggcac gcattctatt ggctgagctg cgttctacgt gggtataaga      480

ggcgcgacca gcgtcggtac cgtcgcagtc ttcggtctga ccaccgtaga acgcaga         537


<210>  3
<211>  1118
<212>  DNA
<213>  Homo sapiens

<400>  3
tccccgagaa gttgggggga ggggtcggca attgaaccgg tgcctagaga aggtggcgcg       60

gggtaaactg ggaaagtgat gtcgtgtact ggctccgcct ttttcccgag ggtgggggag      120

aaccgtatat aagtgcagta gtcgccgtga acgttctttt tcgcaacggg tttgccgcca      180

gaacacaggt aagtgccgtg tgtggttccc gcgggcctgg cctctttacg ggttatggcc      240

cttgcgtgcc ttgaattact tccacctggc tccagtacgt gattcttgat cccgagctgg      300

agccaggggc gggccttgcg ctttaggagc cccttcgcct cgtgcttgag ttgaggcctg      360

gcctgggcgc tggggccgcc gcgtgcgaat ctggtggcac cttcgcgcct gtctcgctgc      420

tttcgataag tctctagcca tttaaaattt ttgatgacct gctgcgacgc tttttttctg      480

gcaagatagt cttgtaaatg cgggccagga tctgcacact ggtatttcgg tttttggggc      540

cgcgggcggc gacggggccc gtgcgtccca gcgcacatgt tcggcgaggc ggggcctgcg      600

agcgcggcca ccgagaatcg gacgggggta gtctcaagct ggccggcctg ctctggtgcc      660

tggcctcgcg ccgccgtgta tcgccccgcc ctgggcggca aggctggccc ggtcggcacc      720

agttgcgtga gcggaaagat ggccgcttcc cggccctgct ccagggggct caaaatggag      780

gacgcggcgc tcgggagagc gggcgggtga gtcacccaca caaaggaaag gggcctttcc      840

gtcctcagcc gtcgcttcat gtgactccac ggagtaccgg gcgccgtcca ggcacctcga      900

ttagttctgg agcttttgga gtacgtcgtc tttaggttgg ggggaggggt tttatgcgat      960

ggagtttccc cacactgagt gggtggagac tgaagttagg ccagcttggc acttgatgta     1020

attctccttg gaatttgccc tttttgagtt tggatcttgg ttcattctca agcctcagac     1080

agtggttcaa agtttttttc ttccatttca ggtgtcgt                             1118


<210>  4
<211>  1348
<212>  DNA
<213>  Mus musculus

<400>  4
agagtaattc atacaaaagg agggatcgcc ttcgcctggg gaagtcccag ggaccgtcgc       60

taaattctca taacccataa tcccggtacc cgccccacca cagtgcgagg agcatgcgct      120

cagggctgag cgcggggaga gcagagcaca caagctcata gaccctggtc gtggggggag      180

gggcgcactg agcggggggg gggggggtga tgggggggag gaccggggag ctggcgcggg      240

gcaaactggg aaagcggtgt cgtgtgctgg ctccgccctc ttcccgaggg tgggggagaa      300

cggtatataa gtgcggcagt cgccttggac gttctttttc gcaacgggtt tgccgtcaga      360

acgcaggtga ggggcgggtg tggcttccgc gggccgccga gctggaggtc ctgctccgag      420

cgggccgggc cccgctgtcg tcggcgggga ttagctgcga gcattcccgc ttcgagttgc      480

gggcggcgcg ggaggcagag tgcgaggcct agcggcaacc ccgtagcctc gcctcgtgtc      540

cggcttgagg cctagcgtgg tgtccgcgcc gccgccgcgt gctactccgg ccgcactctg      600

gtcttttttt ttttgttgtt gttgttgccc tgctgccttc gattgccgtt cagcaatagg      660

ggctaacaaa gggagggtgc ggggcttgct cgcccggagc ccggagaggt catggttggg      720

gaggaatgga gggacaggag tggcggctgg ggcccgcccg ccttcggagc acatgtccga      780

cgccacctgg atggggcgag gcctggggtt tttcccgaag caaccaggct ggggttagcg      840

tgccgaggcc atgtggcccc agcacccggc acgatctggc ttggcggcgc cgcgttgccc      900

tgcctcccta actagggtga ggccatcccg tccggcacca gttgcgtgcg tggaaagatg      960

gccgctcccg ggccctgttg caaggagctc aaaatggagg acgcggcagc ccggtggagc     1020

gggcgggtga gtcacccaca caaaggaaga gggcctggtc cctcaccggc tgctgcttcc     1080

tgtgaccccg tggtcctatc ggccgcaata gtcacctcgg gcttttgagc acggctagtc     1140

gcggcggggg gaggggatgt aatggcgttg gagtttgttc acatttggtg ggtggagact     1200

agtcaggcca gcctggcgct ggaagtcatt tttggaattt gtccccttga gttttgagcg     1260

gagctaattc tcgggcttct tagcggttca aaggtatctt ttaaaccctt ttttaggtgt     1320

tgtgaaaacc accgctaatt caaagcaa                                        1348


<210>  5
<211>  1737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  a combination of the cytomegalovirus early enhancer element and 
       chicken beta-actin promoter

<400>  5
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggactatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg ggtcgaggtg agccccacgt tctgcttcac tctccccatc      420

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg      480

atgggggcgg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg      540

cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc      600

ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg      660

agtcgctgcg ttgccttcgc cccgtgcccc gctccgcgcc gcctcgcgcc gcccgccccg      720

gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt ctcctccggg      780

ctgtaattag cgcttggttt aatgacggct cgtttctttt ctgtggctgc gtgaaagcct      840

taaagggctc cgggagggcc ctttgtgcgg gggggagcgg ctcggggggt gcgtgcgtgt      900

gtgtgtgcgt ggggagcgcc gcgtgcggcc cgcgctgccc ggcggctgtg agcgctgcgg      960

gcgcggcgcg gggctttgtg cgctccgcgt gtgcgcgagg ggagcgcggc cgggggcggt     1020

gccccgcggt gcgggggggc tgcgagggga acaaaggctg cgtgcggggt gtgtgcgtgg     1080

gggggtgagc agggggtgtg ggcgcggcgg tcgggctgta acccccccct gcacccccct     1140

ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc tccgtgcggg gcgtggcgcg     1200

gggctcgccg tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg ggcggggccg     1260

cctcgggccg gggagggctc gggggagggg cgcggcggcc ccggagcgcc ggcggctgtc     1320

gaggcgcggc gagccgcagc cattgccttt tatggtaatc gtgcgagagg gcgcagggac     1380

ttcctttgtc ccaaatctgg cggagccgaa atctgggagg cgccgccgca ccccctctag     1440

cgggcgcggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga gggccttcgt     1500

gcgtcgccgc gccgccgtcc ccttctccat ctccagcctc ggggctgccg cagggggacg     1560

gctgccttcg ggggggacgg ggcagggcgg ggttcggctt ctggcgtgtg accggcggct     1620

ctagagcctc tgctaaccat gttcatgcct tcttcttttt cctacagctc ctgggcaacg     1680

tgctggttgt tgtgctgtct catcattttg gcaaagaatt acccgccgcc accatgg        1737


<210>  6
<211>  524
<212>  DNA
<213>  Mus musculus

<400>  6
caattctacc gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca       60

gccccgctgg gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc      120

accggtaggc gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct      180

cccctagtca ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg      240

gaagtagcac gtctcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg      300

gtaggccttt ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagagg      360

ctgggaaggg gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg ggcgggcgcc      420

cgaaggtcct ccggaggccc ggcattctgc acgcttcaaa agcgcacgtc tgccgcgctg      480

ttctcctctt cctcatctcc gggcctttcg acctgcagcc caag                       524


<210>  7
<211>  1212
<212>  DNA
<213>  Homo sapiens

<400>  7
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag      120

cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag      180

gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg      240

aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat      300

gattatataa ggacgcgccg ggtgtggcac agctagttcc gtcgcagccg ggatttgggt      360

cgcggttctt gtttgtggat cgctgtgatc gtcacttggt gagtagcggg ctgctgggct      420

ggccggggct ttcgtggccg ccgggccgct cggtgggacg gaagcgtgtg gagagaccgc      480

caagggctgt agtctgggtc cgcgagcaag gttgccctga actgggggtt ggggggagcg      540

cagcaaaatg gcggctgttc ccgagtcttg aatggaagac gcttgtgagg cgggctgtga      600

ggtcgttgaa acaaggtggg gggcatggtg ggcggcaaga acccaaggtc ttgaggcctt      660

cgctaatgcg ggaaagctct tattcgggtg agatgggctg gggcaccatc tggggaccct      720

gacgtgaagt ttgtcactga ctggagaact cggtttgtcg tctgttgcgg gggcggcagt      780

tatggcggtg ccgttgggca gtgcacccgt acctttggga gcgcgcgccc tcgtcgtgtc      840

gtgacgtcac ccgttctgtt ggcttataat gcagggtggg gccacctgcc ggtaggtgtg      900

cggtaggctt ttctccgtcg caggacgcag ggttcgggcc tagggtaggc tctcctgaat      960

cgacaggcgc cggacctctg gtgaggggag ggataagtga ggcgtcagtt tctttggtcg     1020

gttttatgta cctatcttct taagtagctg aagctccggt tttgaactat gcgctcgggg     1080

ttggcgagtg tgttttgtga agttttttag gcaccttttg aaatgtaatc atttgggtca     1140

atatgtaatt ttcagtgtta gactagtaaa ttgtccgcta aattctggcc gtttttggct     1200

tttttgttag ac                                                         1212


