                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
 
<120>  METHODS FOR TREATING CANCER IN PATIENTS HAVING IGF-1R INHIBITOR 
       RESISTANCE

<130>  11826-US-PCT

<150>  USSN 61/546756
<151>  2011-10-13

<150>  USSN 61/566773
<151>  2011-12-05

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  4017
<212>  DNA
<213>  homo sapiens

<400>  1
atggcgagcc cgccgcggca cgggccgccc gggccggcga gcggagacgg ccccaacctc       60

aacaacaaca acaacaacaa caaccacagc gtgcgcaagt gcggctacct gcgcaagcag      120

aagcatggcc acaagcgctt cttcgtgctg cgcggacccg gcgcgggcgg cgacgaggcg      180

acggcgggcg gggggtcggc gccgcaaccg ccgcggctcg agtactacga gagcgagaaa      240

aagtggcgga gcaaggcagg cgcgccgaaa cgggtgatcg ctctcgactg ctgcctgaac      300

atcaacaagc gcgccgacgc caagcacaag tacctgatcg ccctctacac caaggacgag      360

tacttcgccg tggccgccga gaacgagcag gagcaggagg gctggtaccg cgcgctcacc      420

gacctggtca gcgagggccg cgcggccgcc ggagacgcgc cccccgccgc cgcgcccgcc      480

gcgtcctgca gcgcctccct gcccggcgcc ctgggcggct ctgccggcgc cgccggggcc      540

gaggacagct acgggctggt ggctcccgcc acggccgcct accgtgaggt gtggcaggtg      600

aacctgaagc ccaagggtct gggccagagc aagaacctga cgggggtgta ccgtctgtgc      660

ctgtctgcgc gcaccatcgg cttcgtgaag ctcaactgcg agcagccgtc ggtgacgctg      720

cagctcatga acatccgccg ctgcggccac tcggacagct tcttcttcat cgaggtgggc      780

cgctcggccg tcacaggccc cggcgagctg tggatgcagg cggacgactc ggtggtggcg      840

cagaacatcc acgagaccat cctggaggcc atgaaggcgc tcaaggagct cttcgagttc      900

cggccgcgca gtaagagcca atcgtcgggg tcgtcggcca cgcaccccat cagcgtcccc      960

ggcgcgcgcc gccaccacca cctggtcaac ctgcccccca gccagacggg cctggtgcgc     1020

cgctcgcgca ccgacagcct ggccgccacc ccgccggcgg ccaagtgcag ctcgtgccgg     1080

gtgcgcaccg ccagcgaggg cgacggcggc gcggcggcgg gagcggcggc cgcgggcgcc     1140

aggccggtgt cggtggctgg gagccccctg agccccgggc cggtgcgcgc gcccctgagc     1200

cgctcgcaca ccctgagcgg cggctgcggc ggccgcggga gcaaggtggc gctgctgccg     1260

gcagggggcg cgctgcaaca cagccgctcc atgtccatgc ccgtggcgca ctcgccgccc     1320

gccgccacca gccccggctc cctgtcgtcc agcagcggcc acggctcggg ctcctacccg     1380

ccgccgcccg gcccgcaccc gcctctgccg catccgctgc accacggccc cggccagcgg     1440

ccctccagcg gcagcgcctc cgcctcgggc tcccccagcg accccggctt catgtccctg     1500

gacgagtacg gctccagccc aggcgacctg cgcgccttct gcagccaccg aagcaacacg     1560

cccgagtcca tcgcggagac gcccccggcc cgagacggcg gcggcggcgg tgagttctac     1620

gggtacatga ccatggacag gcccctgagc cactgtggcc gctcctaccg ccgggtctcg     1680

ggggacgcgg cccaggacct ggaccgaggg ctgcgcaaga ggacctactc cctgaccacg     1740

ccagcccggc agcggccggt gccccagccc tcctctgcct cgctggatga atacaccctg     1800

atgcgggcca ccttctcggg cagcgcgggc cgcctctgcc cgtcctgccc cgcgtcctct     1860

cccaaggtgg cctaccaccc ctacccagag gactacggag acatcgagat cggctcccac     1920

aggagctcca gcagcaacct gggggcagac gacggctaca tgcccatgac gcccggcgcg     1980

gccctcgcgg gcagtgggag cggcagctgc aggagcgacg actacatgcc catgagcccc     2040

gccagcgtgt ccgcccccaa gcagatcttg cagcccaggg ccgccgccgc cgccgccgcc     2100

gccgtgcctt ctgcggggcc tgcggggcca gcacccacct ctgcggcggg caggacattc     2160

ccggcgagcg ggggcggcta caaggccagc tcgcccgccg agagctcccc cgaggacagt     2220

gggtacatgc gcatgtggtg cggttccaag ctgtccatgg agcatgcaga tggcaagctg     2280

ctgcccaacg gggactacct caacgtgtcc cccagcgacg cggtcaccac gggcaccccg     2340

cccgacttct tctccgcagc cctgcacccc ggcggggagc cgctcagggg cgttcccggc     2400

tgctgctaca gctccttgcc ccgctcctac aaggccccct acacctgtgg cggggacagc     2460

gaccagtacg tgctcatgag ctcccccgtg gggcgcatcc tggaggagga gcgtctggag     2520

cctcaggcca cgccagggcc cagccaggcg gccagcgcct tcggggccgg ccccacgcag     2580

ccccctcacc ctgtagtgcc ttcgcccgtg cggcctagcg gcggccgccc ggagggcttc     2640

ttgggccagc gcggccgggc ggtgaggccc acgcgcctgt ccctggaggg gctgcccagc     2700

ctgcccagca tgcacgagta cccactgcca ccggagccca agagccccgg cgagtacatc     2760

aacatcgact ttggcgagcc cggggcccgc ctgtcgccgc ccgcgcctcc cctgctggcg     2820

tcggcggcct cgtcctcctc gctcttgtcc gccagcagcc cggcctcgtc gctgggctca     2880

ggcaccccgg gcaccagcag cgacagccgg cagcggtctc cgctctccga ctacatgaac     2940

ctcgacttca gctcccccaa gtctcctaag ccgggcgccc cgagcggcca ccccgtgggc     3000

tccttggacg gcctcctgtc ccccgaggcc tcctccccgt atccgccgtt gcccccgcgt     3060

ccgtccgcgt ccccgtcgtc gtctctgcag ccgccgccac cgccgccggc cccgggggag     3120

ctgtaccgcc tgccccccgc ctcggccgtt gccaccgccc agggcccggg cgccgcctca     3180

tcgttgtcct cggacaccgg ggacaatggt gactacaccg agatggcttt tggtgtggcc     3240

gccaccccgc cgcaacctat cgcggccccc ccgaagccag aagctgcccg cgtggccagc     3300

ccgacgtcgg gcgtgaagag gctgagcctc atggagcagg tgtcgggagt cgaggccttc     3360

ctgcaggcca gccagccccc ggacccccac cgcggcgcca aggtcatccg cgcagacccg     3420

caggggggcc gccgccgcca cagttccgag accttctcct ccaccacgac ggtcaccccc     3480

gtgtccccgt ccttcgccca caaccccaag cgccacaact cggcctccgt ggaaaatgtc     3540

tctctcagga aaagcagcga gggcggcgtg ggtgtcggcc ctggaggggg cgacgagccg     3600

cccacctccc cacgacagtt gcagccggcg ccccctttgg caccgcaggg ccggccgtgg     3660

accccgggtc agcccggggg cttggtcggt tgtcctggga gcggtggatc gcccatgcgc     3720

agagagacct ctgccggctt ccagaatggt ctcaactaca tcgccatcga cgtgagggag     3780

gagcccgggc tgccacccca gccgcagccg ccgccgccgc cgcttcctca gccgggagac     3840

aagagctcct ggggccggac ccgaagcctc gggggtctca tcagcgctgt gggcgtcggc     3900

agcaccggcg gcgggtgcgg ggggccgggt cccggtgccc tgccccctgc caacacctac     3960

gccagcattg acttcttgtc ccaccacttg aaggaggcca ccatcgtgaa agagtga        4017


<210>  2
<211>  1338
<212>  PRT
<213>  homo sapiens

<400>  2

Met Ala Ser Pro Pro Arg His Gly Pro Pro Gly Pro Ala Ser Gly Asp 
1               5                   10                  15      


Gly Pro Asn Leu Asn Asn Asn Asn Asn Asn Asn Asn His Ser Val Arg 
            20                  25                  30          


Lys Cys Gly Tyr Leu Arg Lys Gln Lys His Gly His Lys Arg Phe Phe 
        35                  40                  45              


Val Leu Arg Gly Pro Gly Ala Gly Gly Asp Glu Ala Thr Ala Gly Gly 
    50                  55                  60                  


Gly Ser Ala Pro Gln Pro Pro Arg Leu Glu Tyr Tyr Glu Ser Glu Lys 
65                  70                  75                  80  


Lys Trp Arg Ser Lys Ala Gly Ala Pro Lys Arg Val Ile Ala Leu Asp 
                85                  90                  95      


Cys Cys Leu Asn Ile Asn Lys Arg Ala Asp Ala Lys His Lys Tyr Leu 
            100                 105                 110         


Ile Ala Leu Tyr Thr Lys Asp Glu Tyr Phe Ala Val Ala Ala Glu Asn 
        115                 120                 125             


Glu Gln Glu Gln Glu Gly Trp Tyr Arg Ala Leu Thr Asp Leu Val Ser 
    130                 135                 140                 


Glu Gly Arg Ala Ala Ala Gly Asp Ala Pro Pro Ala Ala Ala Pro Ala 
145                 150                 155                 160 


Ala Ser Cys Ser Ala Ser Leu Pro Gly Ala Leu Gly Gly Ser Ala Gly 
                165                 170                 175     


Ala Ala Gly Ala Glu Asp Ser Tyr Gly Leu Val Ala Pro Ala Thr Ala 
            180                 185                 190         


Ala Tyr Arg Glu Val Trp Gln Val Asn Leu Lys Pro Lys Gly Leu Gly 
        195                 200                 205             


Gln Ser Lys Asn Leu Thr Gly Val Tyr Arg Leu Cys Leu Ser Ala Arg 
    210                 215                 220                 


Thr Ile Gly Phe Val Lys Leu Asn Cys Glu Gln Pro Ser Val Thr Leu 
225                 230                 235                 240 


Gln Leu Met Asn Ile Arg Arg Cys Gly His Ser Asp Ser Phe Phe Phe 
                245                 250                 255     


Ile Glu Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Leu Trp Met 
            260                 265                 270         


Gln Ala Asp Asp Ser Val Val Ala Gln Asn Ile His Glu Thr Ile Leu 
        275                 280                 285             


Glu Ala Met Lys Ala Leu Lys Glu Leu Phe Glu Phe Arg Pro Arg Ser 
    290                 295                 300                 


Lys Ser Gln Ser Ser Gly Ser Ser Ala Thr His Pro Ile Ser Val Pro 
305                 310                 315                 320 


Gly Ala Arg Arg His His His Leu Val Asn Leu Pro Pro Ser Gln Thr 
                325                 330                 335     


Gly Leu Val Arg Arg Ser Arg Thr Asp Ser Leu Ala Ala Thr Pro Pro 
            340                 345                 350         


Ala Ala Lys Cys Ser Ser Cys Arg Val Arg Thr Ala Ser Glu Gly Asp 
        355                 360                 365             


Gly Gly Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Arg Pro Val Ser 
    370                 375                 380                 


Val Ala Gly Ser Pro Leu Ser Pro Gly Pro Val Arg Ala Pro Leu Ser 
385                 390                 395                 400 


Arg Ser His Thr Leu Ser Gly Gly Cys Gly Gly Arg Gly Ser Lys Val 
                405                 410                 415     


Ala Leu Leu Pro Ala Gly Gly Ala Leu Gln His Ser Arg Ser Met Ser 
            420                 425                 430         


Met Pro Val Ala His Ser Pro Pro Ala Ala Thr Ser Pro Gly Ser Leu 
        435                 440                 445             


Ser Ser Ser Ser Gly His Gly Ser Gly Ser Tyr Pro Pro Pro Pro Gly 
    450                 455                 460                 


Pro His Pro Pro Leu Pro His Pro Leu His His Gly Pro Gly Gln Arg 
465                 470                 475                 480 


Pro Ser Ser Gly Ser Ala Ser Ala Ser Gly Ser Pro Ser Asp Pro Gly 
                485                 490                 495     


Phe Met Ser Leu Asp Glu Tyr Gly Ser Ser Pro Gly Asp Leu Arg Ala 
            500                 505                 510         


Phe Cys Ser His Arg Ser Asn Thr Pro Glu Ser Ile Ala Glu Thr Pro 
        515                 520                 525             


Pro Ala Arg Asp Gly Gly Gly Gly Gly Glu Phe Tyr Gly Tyr Met Thr 
    530                 535                 540                 


Met Asp Arg Pro Leu Ser His Cys Gly Arg Ser Tyr Arg Arg Val Ser 
545                 550                 555                 560 


Gly Asp Ala Ala Gln Asp Leu Asp Arg Gly Leu Arg Lys Arg Thr Tyr 
                565                 570                 575     


Ser Leu Thr Thr Pro Ala Arg Gln Arg Pro Val Pro Gln Pro Ser Ser 
            580                 585                 590         


Ala Ser Leu Asp Glu Tyr Thr Leu Met Arg Ala Thr Phe Ser Gly Ser 
        595                 600                 605             


Ala Gly Arg Leu Cys Pro Ser Cys Pro Ala Ser Ser Pro Lys Val Ala 
    610                 615                 620                 


Tyr His Pro Tyr Pro Glu Asp Tyr Gly Asp Ile Glu Ile Gly Ser His 
625                 630                 635                 640 


Arg Ser Ser Ser Ser Asn Leu Gly Ala Asp Asp Gly Tyr Met Pro Met 
                645                 650                 655     


Thr Pro Gly Ala Ala Leu Ala Gly Ser Gly Ser Gly Ser Cys Arg Ser 
            660                 665                 670         


Asp Asp Tyr Met Pro Met Ser Pro Ala Ser Val Ser Ala Pro Lys Gln 
        675                 680                 685             


Ile Leu Gln Pro Arg Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Ser 
    690                 695                 700                 


Ala Gly Pro Ala Gly Pro Ala Pro Thr Ser Ala Ala Gly Arg Thr Phe 
705                 710                 715                 720 


Pro Ala Ser Gly Gly Gly Tyr Lys Ala Ser Ser Pro Ala Glu Ser Ser 
                725                 730                 735     


Pro Glu Asp Ser Gly Tyr Met Arg Met Trp Cys Gly Ser Lys Leu Ser 
            740                 745                 750         


Met Glu His Ala Asp Gly Lys Leu Leu Pro Asn Gly Asp Tyr Leu Asn 
        755                 760                 765             


Val Ser Pro Ser Asp Ala Val Thr Thr Gly Thr Pro Pro Asp Phe Phe 
    770                 775                 780                 


Ser Ala Ala Leu His Pro Gly Gly Glu Pro Leu Arg Gly Val Pro Gly 
785                 790                 795                 800 


Cys Cys Tyr Ser Ser Leu Pro Arg Ser Tyr Lys Ala Pro Tyr Thr Cys 
                805                 810                 815     


Gly Gly Asp Ser Asp Gln Tyr Val Leu Met Ser Ser Pro Val Gly Arg 
            820                 825                 830         


Ile Leu Glu Glu Glu Arg Leu Glu Pro Gln Ala Thr Pro Gly Pro Ser 
        835                 840                 845             


Gln Ala Ala Ser Ala Phe Gly Ala Gly Pro Thr Gln Pro Pro His Pro 
    850                 855                 860                 


Val Val Pro Ser Pro Val Arg Pro Ser Gly Gly Arg Pro Glu Gly Phe 
865                 870                 875                 880 


Leu Gly Gln Arg Gly Arg Ala Val Arg Pro Thr Arg Leu Ser Leu Glu 
                885                 890                 895     


Gly Leu Pro Ser Leu Pro Ser Met His Glu Tyr Pro Leu Pro Pro Glu 
            900                 905                 910         


Pro Lys Ser Pro Gly Glu Tyr Ile Asn Ile Asp Phe Gly Glu Pro Gly 
        915                 920                 925             


Ala Arg Leu Ser Pro Pro Ala Pro Pro Leu Leu Ala Ser Ala Ala Ser 
    930                 935                 940                 


Ser Ser Ser Leu Leu Ser Ala Ser Ser Pro Ala Ser Ser Leu Gly Ser 
945                 950                 955                 960 


Gly Thr Pro Gly Thr Ser Ser Asp Ser Arg Gln Arg Ser Pro Leu Ser 
                965                 970                 975     


Asp Tyr Met Asn Leu Asp Phe Ser Ser Pro Lys Ser Pro Lys Pro Gly 
            980                 985                 990         


Ala Pro Ser Gly His Pro Val Gly  Ser Leu Asp Gly Leu  Leu Ser Pro 
        995                 1000                 1005             


Glu Ala  Ser Ser Pro Tyr Pro  Pro Leu Pro Pro Arg  Pro Ser Ala 
    1010                 1015                 1020             


Ser Pro  Ser Ser Ser Leu Gln  Pro Pro Pro Pro Pro  Pro Ala Pro 
    1025                 1030                 1035             


Gly Glu  Leu Tyr Arg Leu Pro  Pro Ala Ser Ala Val  Ala Thr Ala 
    1040                 1045                 1050             


Gln Gly  Pro Gly Ala Ala Ser  Ser Leu Ser Ser Asp  Thr Gly Asp 
    1055                 1060                 1065             


Asn Gly  Asp Tyr Thr Glu Met  Ala Phe Gly Val Ala  Ala Thr Pro 
    1070                 1075                 1080             


Pro Gln  Pro Ile Ala Ala Pro  Pro Lys Pro Glu Ala  Ala Arg Val 
    1085                 1090                 1095             


Ala Ser  Pro Thr Ser Gly Val  Lys Arg Leu Ser Leu  Met Glu Gln 
    1100                 1105                 1110             


Val Ser  Gly Val Glu Ala Phe  Leu Gln Ala Ser Gln  Pro Pro Asp 
    1115                 1120                 1125             


Pro His  Arg Gly Ala Lys Val  Ile Arg Ala Asp Pro  Gln Gly Gly 
    1130                 1135                 1140             


Arg Arg  Arg His Ser Ser Glu  Thr Phe Ser Ser Thr  Thr Thr Val 
    1145                 1150                 1155             


Thr Pro  Val Ser Pro Ser Phe  Ala His Asn Pro Lys  Arg His Asn 
    1160                 1165                 1170             


Ser Ala  Ser Val Glu Asn Val  Ser Leu Arg Lys Ser  Ser Glu Gly 
    1175                 1180                 1185             


Gly Val  Gly Val Gly Pro Gly  Gly Gly Asp Glu Pro  Pro Thr Ser 
    1190                 1195                 1200             


Pro Arg  Gln Leu Gln Pro Ala  Pro Pro Leu Ala Pro  Gln Gly Arg 
    1205                 1210                 1215             


Pro Trp  Thr Pro Gly Gln Pro  Gly Gly Leu Val Gly  Cys Pro Gly 
    1220                 1225                 1230             


Ser Gly  Gly Ser Pro Met Arg  Arg Glu Thr Ser Ala  Gly Phe Gln 
    1235                 1240                 1245             


Asn Gly  Leu Asn Tyr Ile Ala  Ile Asp Val Arg Glu  Glu Pro Gly 
    1250                 1255                 1260             


Leu Pro  Pro Gln Pro Gln Pro  Pro Pro Pro Pro Leu  Pro Gln Pro 
    1265                 1270                 1275             


Gly Asp  Lys Ser Ser Trp Gly  Arg Thr Arg Ser Leu  Gly Gly Leu 
    1280                 1285                 1290             


Ile Ser  Ala Val Gly Val Gly  Ser Thr Gly Gly Gly  Cys Gly Gly 
    1295                 1300                 1305             


Pro Gly  Pro Gly Ala Leu Pro  Pro Ala Asn Thr Tyr  Ala Ser Ile 
    1310                 1315                 1320             


Asp Phe  Leu Ser His His Leu  Lys Glu Ala Thr Ile  Val Lys Glu 
    1325                 1330                 1335             


<210>  3
<211>  723
<212>  DNA
<213>  homo sapiens

<400>  3
atgacccccc acaggctgct gccaccgctg ctgctgctgc tagctctgct gctcgctgcc       60

agcccaggag gcgccttggc gcggtgccca ggctgcgggc aaggggtgca ggcgggttgt      120

ccagggggct gcgtggagga ggaggatggg gggtcgccag ccgagggctg cgcggaagct      180

gagggctgtc tcaggaggga ggggcaggag tgcggggtct acacccctaa ctgcgcccca      240

ggactgcagt gccatccgcc caaggacgac gaggcgcctt tgcgggcgct gctgctcggc      300

cgaggccgct gccttccggc ccgcgcgcct gctgttgcag aggagaatcc taaggagagt      360

aaaccccaag caggcactgc ccgcccacag gatgtgaacc gcagagacca acagaggaat      420

ccaggcacct ctaccacgcc ctcccagccc aattctgcgg gtgtccaaga cactgagatg      480

ggcccatgcc gtagacatct ggactcagtg ctgcagcaac tccagactga ggtctaccga      540

ggggctcaaa cactctacgt gcccaattgt gaccatcgag gcttctaccg gaagcggcag      600

tgccgctcct cccaggggca gcgccgaggt ccctgctggt gtgtggatcg gatgggcaag      660

tccctgccag ggtctccaga tggcaatgga agctcctcct gccccactgg gagtagcggc      720

taa                                                                    723


<210>  4
<211>  240
<212>  PRT
<213>  homo sapiens

<400>  4

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210>  5
<211>  4149
<212>  DNA
<213>  homo sapiens

<400>  5
atggccaccg ggggccggcg gggggcggcg gccgcgccgc tgctggtggc ggtggccgcg       60

ctgctactgg gcgccgcggg ccacctgtac cccggagagg tgtgtcccgg catggatatc      120

cggaacaacc tcactaggtt gcatgagctg gagaattgct ctgtcatcga aggacacttg      180

cagatactct tgatgttcaa aacgaggccc gaagatttcc gagacctcag tttccccaaa      240

ctcatcatga tcactgatta cttgctgctc ttccgggtct atgggctcga gagcctgaag      300

gacctgttcc ccaacctcac ggtcatccgg ggatcacgac tgttctttaa ctacgcgctg      360

gtcatcttcg agatggttca cctcaaggaa ctcggcctct acaacctgat gaacatcacc      420

cggggttctg tccgcatcga gaagaacaat gagctctgtt acttggccac tatcgactgg      480

tcccgtatcc tggattccgt ggaggataat tacatcgtgt tgaacaaaga tgacaacgag      540

gagtgtggag acatctgtcc gggtaccgcg aagggcaaga ccaactgccc cgccaccgtc      600

atcaacgggc agtttgtcga acgatgttgg actcatagtc actgccagaa agtttgcccg      660

accatctgta agtcacacgg ctgcaccgcc gaaggcctct gttgccacag cgagtgcctg      720

ggcaactgtt ctcagcccga cgaccccacc aagtgcgtgg cctgccgcaa cttctacctg      780

gacggcaggt gtgtggagac ctgcccgccc ccgtactacc acttccagga ctggcgctgt      840

gtgaacttca gcttctgcca ggacctgcac cacaaatgca agaactcgcg gaggcagggc      900

tgccaccagt acgtcattca caacaacaag tgcatccctg agtgtccctc cgggtacacg      960

atgaattcca gcaacttgct gtgcacccca tgcctgggtc cctgtcccaa ggtgtgccac     1020

ctcctagaag gcgagaagac catcgactcg gtgacgtctg cccaggagct ccgaggatgc     1080

accgtcatca acgggagtct gatcatcaac attcgaggag gcaacaatct ggcagctgag     1140

ctagaagcca acctcggcct cattgaagaa atttcagggt atctaaaaat ccgccgatcc     1200

tacgctctgg tgtcactttc cttcttccgg aagttacgtc tgattcgagg agagaccttg     1260

gaaattggga actactcctt ctatgccttg gacaaccaga acctaaggca gctctgggac     1320

tggagcaaac acaacctcac catcactcag gggaaactct tcttccacta taaccccaaa     1380

ctctgcttgt cagaaatcca caagatggaa gaagtttcag gaaccaaggg gcgccaggag     1440

agaaacgaca ttgccctgaa gaccaatggg gaccaggcat cctgtgaaaa tgagttactt     1500

aaattttctt acattcggac atcttttgac aagatcttgc tgagatggga gccgtactgg     1560

ccccccgact tccgagacct cttggggttc atgctgttct acaaagaggc cccttatcag     1620

aatgtgacgg agttcgacgg gcaggatgcg tgtggttcca acagttggac ggtggtagac     1680

attgacccac ccctgaggtc caacgacccc aaatcacaga accacccagg gtggctgatg     1740

cggggtctca agccctggac ccagtatgcc atctttgtga agaccctggt caccttttcg     1800

gatgaacgcc ggacctatgg ggccaagagt gacatcattt atgtccagac agatgccacc     1860

aacccctctg tgcccctgga tccaatctca gtgtctaact catcatccca gattattctg     1920

aagtggaaac caccctccga ccccaatggc aacatcaccc actacctggt tttctgggag     1980

aggcaggcgg aagacagtga gctgttcgag ctggattatt gcctcaaagg gctgaagctg     2040

ccctcgagga cctggtctcc accattcgag tctgaagatt ctcagaagca caaccagagt     2100

gagtatgagg attcggccgg cgaatgctgc tcctgtccaa agacagactc tcagatcctg     2160

aaggagctgg aggagtcctc gtttaggaag acgtttgagg attacctgca caacgtggtt     2220

ttcgtcccca gaaaaacctc ttcaggcact ggtgccgagg accctaggcc atctcggaaa     2280

cgcaggtccc ttggcgatgt tgggaatgtg acggtggccg tgcccacggt ggcagctttc     2340

cccaacactt cctcgaccag cgtgcccacg agtccggagg agcacaggcc ttttgagaag     2400

gtggtgaaca aggagtcgct ggtcatctcc ggcttgcgac acttcacggg ctatcgcatc     2460

gagctgcagg cttgcaacca ggacacccct gaggaacggt gcagtgtggc agcctacgtc     2520

agtgcgagga ccatgcctga agccaaggct gatgacattg ttggccctgt gacgcatgaa     2580

atctttgaga acaacgtcgt ccacttgatg tggcaggagc cgaaggagcc caatggtctg     2640

atcgtgctgt atgaagtgag ttatcggcga tatggtgatg aggagctgca tctctgcgtc     2700

tcccgcaagc acttcgctct ggaacggggc tgcaggctgc gtgggctgtc accggggaac     2760

tacagcgtgc gaatccgggc cacctccctt gcgggcaacg gctcttggac ggaacccacc     2820

tatttctacg tgacagacta tttagacgtc ccgtcaaata ttgcaaaaat tatcatcggc     2880

cccctcatct ttgtctttct cttcagtgtt gtgattggaa gtatttatct attcctgaga     2940

aagaggcagc cagatgggcc gctgggaccg ctttacgctt cttcaaaccc tgagtatctc     3000

agtgccagtg atgtgtttcc atgctctgtg tacgtgccgg acgagtggga ggtgtctcga     3060

gagaagatca ccctccttcg agagctgggg cagggctcct tcggcatggt gtatgagggc     3120

aatgccaggg acatcatcaa gggtgaggca gagacccgcg tggcggtgaa gacggtcaac     3180

gagtcagcca gtctccgaga gcggattgag ttcctcaatg aggcctcggt catgaagggc     3240

ttcacctgcc atcacgtggt gcgcctcctg ggagtggtgt ccaagggcca gcccacgctg     3300

gtggtgatgg agctgatggc tcacggagac ctgaagagct acctccgttc tctgcggcca     3360

gaggctgaga ataatcctgg ccgccctccc cctacccttc aagagatgat tcagatggcg     3420

gcagagattg ctgacgggat ggcctacctg aacgccaaga agtttgtgca tcgggacctg     3480

gcagcgagaa actgcatggt cgcccatgat tttactgtca aaattggaga ctttggaatg     3540

accagagaca tctatgaaac ggattactac cggaaagggg gcaagggtct gctccctgta     3600

cggtggatgg caccggagtc cctgaaggat ggggtcttca ccacttcttc tgacatgtgg     3660

tcctttggcg tggtcctttg ggaaatcacc agcttggcag aacagcctta ccaaggcctg     3720

tctaatgaac aggtgttgaa atttgtcatg gatggagggt atctggatca acccgacaac     3780

tgtccagaga gagtcactga cctcatgcgc atgtgctggc aattcaaccc caagatgagg     3840

ccaaccttcc tggagattgt caacctgctc aaggacgacc tgcaccccag ctttccagag     3900

gtgtcgttct tccacagcga ggagaacaag gctcccgaga gtgaggagct ggagatggag     3960

tttgaggaca tggagaatgt gcccctggac cgttcctcgc actgtcagag ggaggaggcg     4020

gggggccggg atggagggtc ctcgctgggt ttcaagcgga gctacgagga acacatccct     4080

tacacacaca tgaacggagg caagaaaaac gggcggattc tgaccttgcc tcggtccaat     4140

ccttcctaa                                                             4149


<210>  6
<211>  1382
<212>  PRT
<213>  homo sapiens

<400>  6

Met Ala Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His 
        35                  40                  45              


Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu 
    50                  55                  60                  


Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys 
65                  70                  75                  80  


Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu 
                85                  90                  95      


Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser 
            100                 105                 110         


Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu 
        115                 120                 125             


Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val 
    130                 135                 140                 


Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp 
145                 150                 155                 160 


Ser Arg Ile Leu Asp Ser Val Glu Asp Asn Tyr Ile Val Leu Asn Lys 
                165                 170                 175     


Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly 
            180                 185                 190         


Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg 
        195                 200                 205             


Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys 
    210                 215                 220                 


Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu 
225                 230                 235                 240 


Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg 
                245                 250                 255     


Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr 
            260                 265                 270         


Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp 
        275                 280                 285             


Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr 
    290                 295                 300                 


Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr 
305                 310                 315                 320 


Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro 
                325                 330                 335     


Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr 
            340                 345                 350         


Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile 
        355                 360                 365             


Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn 
    370                 375                 380                 


Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser 
385                 390                 395                 400 


Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg 
                405                 410                 415     


Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn 
            420                 425                 430         


Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Ile 
        435                 440                 445             


Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser 
    450                 455                 460                 


Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu 
465                 470                 475                 480 


Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Gln Ala Ser Cys Glu 
                485                 490                 495     


Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile 
            500                 505                 510         


Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu 
        515                 520                 525             


Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu 
    530                 535                 540                 


Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp 
545                 550                 555                 560 


Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro 
                565                 570                 575     


Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe 
            580                 585                 590         


Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala 
        595                 600                 605             


Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val 
    610                 615                 620                 


Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu 
625                 630                 635                 640 


Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu 
                645                 650                 655     


Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp 
            660                 665                 670         


Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro 
        675                 680                 685             


Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu 
705                 710                 715                 720 


Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu 
                725                 730                 735     


His Asn Val Val Phe Val Pro Arg Lys Thr Ser Ser Gly Thr Gly Ala 
            740                 745                 750         


Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu Gly Asp Val Gly 
        755                 760                 765             


Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe Pro Asn Thr Ser 
    770                 775                 780                 


Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg Pro Phe Glu Lys 
785                 790                 795                 800 


Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu Arg His Phe Thr 
                805                 810                 815     


Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp Thr Pro Glu Glu 
            820                 825                 830         


Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr Met Pro Glu Ala 
        835                 840                 845             


Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu Ile Phe Glu Asn 
    850                 855                 860                 


Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu Pro Asn Gly Leu 
865                 870                 875                 880 


Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly Asp Glu Glu Leu 
                885                 890                 895     


His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu Arg Gly Cys Arg 
            900                 905                 910         


Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile Arg Ala Thr 
        915                 920                 925             


Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr Tyr Phe Tyr Val 
    930                 935                 940                 


Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys Ile Ile Ile Gly 
945                 950                 955                 960 


Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile Gly Ser Ile Tyr 
                965                 970                 975     


Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly Pro Leu Gly Pro Leu Tyr 
            980                 985                 990         


Ala Ser Ser Asn Pro Glu Tyr Leu  Ser Ala Ser Asp Val  Phe Pro Cys 
        995                 1000                 1005             


Ser Val  Tyr Val Pro Asp Glu  Trp Glu Val Ser Arg  Glu Lys Ile 
    1010                 1015                 1020             


Thr Leu  Leu Arg Glu Leu Gly  Gln Gly Ser Phe Gly  Met Val Tyr 
    1025                 1030                 1035             


Glu Gly  Asn Ala Arg Asp Ile  Ile Lys Gly Glu Ala  Glu Thr Arg 
    1040                 1045                 1050             


Val Ala  Val Lys Thr Val Asn  Glu Ser Ala Ser Leu  Arg Glu Arg 
    1055                 1060                 1065             


Ile Glu  Phe Leu Asn Glu Ala  Ser Val Met Lys Gly  Phe Thr Cys 
    1070                 1075                 1080             


His His  Val Val Arg Leu Leu  Gly Val Val Ser Lys  Gly Gln Pro 
    1085                 1090                 1095             


Thr Leu  Val Val Met Glu Leu  Met Ala His Gly Asp  Leu Lys Ser 
    1100                 1105                 1110             


Tyr Leu  Arg Ser Leu Arg Pro  Glu Ala Glu Asn Asn  Pro Gly Arg 
    1115                 1120                 1125             


Pro Pro  Pro Thr Leu Gln Glu  Met Ile Gln Met Ala  Ala Glu Ile 
    1130                 1135                 1140             


Ala Asp  Gly Met Ala Tyr Leu  Asn Ala Lys Lys Phe  Val His Arg 
    1145                 1150                 1155             


Asp Leu  Ala Ala Arg Asn Cys  Met Val Ala His Asp  Phe Thr Val 
    1160                 1165                 1170             


Lys Ile  Gly Asp Phe Gly Met  Thr Arg Asp Ile Tyr  Glu Thr Asp 
    1175                 1180                 1185             


Tyr Tyr  Arg Lys Gly Gly Lys  Gly Leu Leu Pro Val  Arg Trp Met 
    1190                 1195                 1200             


Ala Pro  Glu Ser Leu Lys Asp  Gly Val Phe Thr Thr  Ser Ser Asp 
    1205                 1210                 1215             


Met Trp  Ser Phe Gly Val Val  Leu Trp Glu Ile Thr  Ser Leu Ala 
    1220                 1225                 1230             


Glu Gln  Pro Tyr Gln Gly Leu  Ser Asn Glu Gln Val  Leu Lys Phe 
    1235                 1240                 1245             


Val Met  Asp Gly Gly Tyr Leu  Asp Gln Pro Asp Asn  Cys Pro Glu 
    1250                 1255                 1260             


Arg Val  Thr Asp Leu Met Arg  Met Cys Trp Gln Phe  Asn Pro Lys 
    1265                 1270                 1275             


Met Arg  Pro Thr Phe Leu Glu  Ile Val Asn Leu Leu  Lys Asp Asp 
    1280                 1285                 1290             


Leu His  Pro Ser Phe Pro Glu  Val Ser Phe Phe His  Ser Glu Glu 
    1295                 1300                 1305             


Asn Lys  Ala Pro Glu Ser Glu  Glu Leu Glu Met Glu  Phe Glu Asp 
    1310                 1315                 1320             


Met Glu  Asn Val Pro Leu Asp  Arg Ser Ser His Cys  Gln Arg Glu 
    1325                 1330                 1335             


Glu Ala  Gly Gly Arg Asp Gly  Gly Ser Ser Leu Gly  Phe Lys Arg 
    1340                 1345                 1350             


Ser Tyr  Glu Glu His Ile Pro  Tyr Thr His Met Asn  Gly Gly Lys 
    1355                 1360                 1365             


Lys Asn  Gly Arg Ile Leu Thr  Leu Pro Arg Ser Asn  Pro Ser 
    1370                 1375                 1380         


<210>  7
<211>  4104
<212>  DNA
<213>  homo sapiens

<400>  7
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttca tccatctgat catcgctctg     2820

cccgtcgctg tcctgttgat cgtgggaggg ttggtgatta tgctgtacgt cttccataga     2880

aagagaaata acagcaggct ggggaatgga gtgctgtatg cctctgtgaa cccggagtac     2940

ttcagcgctg ctgatgtgta cgttcctgat gagtgggagg tggctcggga gaagatcacc     3000

atgagccggg aacttgggca ggggtcgttt gggatggtct atgaaggagt tgccaagggt     3060

gtggtgaaag atgaacctga aaccagagtg gccattaaaa cagtgaacga ggccgcaagc     3120

atgcgtgaga ggattgagtt tctcaacgaa gcttctgtga tgaaggagtt caattgtcac     3180

catgtggtgc gattgctggg tgtggtgtcc caaggccagc caacactggt catcatggaa     3240

ctgatgacac ggggcgatct caaaagttat ctccggtctc tgaggccaga aatggagaat     3300

aatccagtcc tagcacctcc aagcctgagc aagatgattc agatggccgg agagattgca     3360

gacggcatgg catacctcaa cgccaataag ttcgtccaca gagaccttgc tgcccggaat     3420

tgcatggtag ccgaagattt cacagtcaaa atcggagatt ttggtatgac gcgagatatc     3480

tatgagacag actattaccg gaaaggaggg aaagggctgc tgcccgtgcg ctggatgtct     3540

cctgagtccc tcaaggatgg agtcttcacc acttactcgg acgtctggtc cttcggggtc     3600

gtcctctggg agatcgccac actggccgag cagccctacc agggcttgtc caacgagcaa     3660

gtccttcgct tcgtcatgga gggcggcctt ctggacaagc cagacaactg tcctgacatg     3720

ctgtttgaac tgatgcgcat gtgctggcag tataacccca agatgaggcc ttccttcctg     3780

gagatcatca gcagcatcaa agaggagatg gagcctggct tccgggaggt ctccttctac     3840

tacagcgagg agaacaagct gcccgagccg gaggagctgg acctggagcc agagaacatg     3900

gagagcgtcc ccctggaccc ctcggcctcc tcgtcctccc tgccactgcc cgacagacac     3960

tcaggacaca aggccgagaa cggccccggc cctggggtgc tggtcctccg cgccagcttc     4020

gacgagagac agccttacgc ccacatgaac gggggccgca agaacgagcg ggccttgccg     4080

ctgccccagt cttcgacctg ctga                                            4104


<210>  8
<211>  1367
<212>  PRT
<213>  homo sapiens

<400>  8

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val 
    930                 935                 940                 


Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg 
945                 950                 955                 960 


Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val 
                965                 970                 975     


Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp 
            980                 985                 990         


Glu Val Ala Arg Glu Lys Ile Thr  Met Ser Arg Glu Leu  Gly Gln Gly 
        995                 1000                 1005             


Ser Phe  Gly Met Val Tyr Glu  Gly Val Ala Lys Gly  Val Val Lys 
    1010                 1015                 1020             


Asp Glu  Pro Glu Thr Arg Val  Ala Ile Lys Thr Val  Asn Glu Ala 
    1025                 1030                 1035             


Ala Ser  Met Arg Glu Arg Ile  Glu Phe Leu Asn Glu  Ala Ser Val 
    1040                 1045                 1050             


Met Lys  Glu Phe Asn Cys His  His Val Val Arg Leu  Leu Gly Val 
    1055                 1060                 1065             


Val Ser  Gln Gly Gln Pro Thr  Leu Val Ile Met Glu  Leu Met Thr 
    1070                 1075                 1080             


Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg Ser Leu Arg  Pro Glu Met 
    1085                 1090                 1095             


Glu Asn  Asn Pro Val Leu Ala  Pro Pro Ser Leu Ser  Lys Met Ile 
    1100                 1105                 1110             


Gln Met  Ala Gly Glu Ile Ala  Asp Gly Met Ala Tyr  Leu Asn Ala 
    1115                 1120                 1125             


Asn Lys  Phe Val His Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val 
    1130                 1135                 1140             


Ala Glu  Asp Phe Thr Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg 
    1145                 1150                 1155             


Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu 
    1160                 1165                 1170             


Leu Pro  Val Arg Trp Met Ser  Pro Glu Ser Leu Lys  Asp Gly Val 
    1175                 1180                 1185             


Phe Thr  Thr Tyr Ser Asp Val  Trp Ser Phe Gly Val  Val Leu Trp 
    1190                 1195                 1200             


Glu Ile  Ala Thr Leu Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn 
    1205                 1210                 1215             


Glu Gln  Val Leu Arg Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys 
    1220                 1225                 1230             


Pro Asp  Asn Cys Pro Asp Met  Leu Phe Glu Leu Met  Arg Met Cys 
    1235                 1240                 1245             


Trp Gln  Tyr Asn Pro Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile 
    1250                 1255                 1260             


Ser Ser  Ile Lys Glu Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser 
    1265                 1270                 1275             


Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu 
    1280                 1285                 1290             


Asp Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 
    1295                 1300                 1305             


Ala Ser  Ser Ser Ser Leu Pro  Leu Pro Asp Arg His  Ser Gly His 
    1310                 1315                 1320             


Lys Ala  Glu Asn Gly Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala 
    1325                 1330                 1335             


Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg 
    1340                 1345                 1350             


Lys Asn  Glu Arg Ala Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 
    1355                 1360                 1365         


<210>  9
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Forward oligonucleotide primer

<400>  9
tttcgtcccc aggccatc                                                     18


<210>  10
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse oligonucleotide primer

<400>  10
gcccgtgaag tgtcgc                                                       16


<210>  11
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide probe

<400>  11
ttgagaaggt ggtgaaca                                                     18


