                         SEQUENCE LISTING

<110>  The United States of America, as Represented by the Secretary, Department of 
       Health and Human Services
       Dimitrov, Dimiter S.
       Chen, Weizao
       Feng, Yang
 
<120>  MONOSPECIFIC AND BISPECIFIC HUMAN MONOCLONAL ANTIBODIES TARGETING
        INSULIN-LIKE GROWTH FACTOR II (IGF-II)

<130>  4239-87577-02

<150>  US 61/548,164
<151>  2011-10-17

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Gln Trp Leu Ala Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Asp Leu Leu Ile 
        35                  40                  45              


Asn Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ser Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105             


<210>  3
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  4
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  5
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X can be D or G

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X can be K or R

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  X can be S or R

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  X can be S or R

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  X can be Y or H

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Phe Asp Phe Xaa Tyr Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Ser Gly Gly Thr Lys Met Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Xaa Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Ala Thr Cys Xaa Gly Gly Xaa Cys Tyr Ser Phe Tyr 
            100                 105                 110         


Xaa Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  6
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Phe Asp Phe Asp Tyr Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Ser Gly Gly Thr Lys Met Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Ala Thr Cys Arg Gly Gly Arg Cys Tyr Ser Phe Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Gly Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys 
        355         


<210>  7
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Gln Trp Leu Ala Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Arg Ala Pro Asp Leu Leu Ile Asn Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Leu Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
            260                 265                 270         


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
        275                 280                 285             


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
    290                 295                 300                 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
305                 310                 315                 320 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
                325                 330                 335     


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
            340                 345                 350         


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
        355                 360                 365             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    370                 375                 380                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
385                 390                 395                 400 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                405                 410                 415     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            420                 425                 430         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        435                 440                 445             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    450                 455                 460                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
465                 470                 475                 480 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                485                 490                 495     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            500                 505                 510         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        515                 520                 525             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    530                 535                 540                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
545                 550                 555                 560 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                565                 570                 575     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585                 590 


<210>  8
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Phe Asp Phe Asp Tyr Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Ser Gly Gly Thr Lys Met Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Ala Thr Cys Arg Gly Gly Arg Cys Tyr Ser Phe Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    130                 135                 140                 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
145                 150                 155                 160 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
                165                 170                 175     


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
            180                 185                 190         


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
        195                 200                 205             


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
    210                 215                 220                 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
225                 230                 235                 240 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                245                 250 


<210>  9
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  9
caagtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatgtg      300

cagtggctgg catacggtat ggacgtctgg ggccaaggga ccacggtcac cgtgagctca      360

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  10
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  10
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagt agctatttaa attggtatca gcagaagcca      120

gggagagccc ctgacctcct gatcaatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggaccgac ttcactctca ccatcagcag tctccaacct      240

gaagattttg caacttactt ctgtcaacag agttacagtc ttccgttcac tttcggcgga      300

gggaccaagg tggagatcaa aggaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  11
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  11
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctcttcttt cgatttcgat tattatgaaa tgagctgggt ccgccaggct      120

ccaggacaac ggcttgagtg ggttgcatac attagtaaga gtggcggtac caaaatgtat      180

gcagactcgg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acagccatgt attactgtgc gaaagatcgg      300

gcaacttgta gtggtggtag ctgctactcc ttttactacg gtatggacgt ctggggccaa      360

ggcaccctgg tcaccgtctc ctca                                             384


<210>  12
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  12
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctcttcttt cgatttcgat tattatgaaa tgagctgggt ccgccaggct      120

ccaggacaac ggcttgagtg ggttgcatac attagtaaga gtggcggtac caaaatgtat      180

gcagactcgg tgaagggccg attcaccatc tccagagaca attccaggaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acagccatgt attactgtgc gaaagatcgg      300

gcaacttgta gaggtggtag ctgctactcc ttttaccacg gtatggacgt ctggggccaa      360

ggcaccctgg tcaccgtctc ctca                                             384


<210>  13
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  13
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctcttcttt cgatttcgat tattatgaaa tgagctgggt ccgccaggct      120

ccaggacaac ggcttgagtg ggttgcatac attagtaaga gtggcggtac caaaatgtat      180

gcagactcgg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acagccatgt attactgtgc gaaagatcgg      300

gcaacttgta gaggtggtcg ctgctactcc ttttactacg gtatggacgt ctggggccaa      360

ggcaccctgg tcaccgtctc ctca                                             384


<210>  14
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  14
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctcttcttt cgatttcggt tattatgaaa tgagctgggt ccgccaggct      120

ccaggacaac ggcttgagtg ggttgcatac attagtaaga gtggcggtac caaaatgtat      180

gcagactcgg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acagccatgt attactgtgc gaaagatcgg      300

gcaacttgta gtggtggtag atgctactcc ttttactacg gtatggacgt ctggggccaa      360

ggcaccctgg tcaccgtctc ctca                                             384


<210>  15
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  15
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctcttcttt cgatttcgat tattatgaaa tgagctgggt ccgccaggcc      120

ccaggacaac ggcttgagtg ggttgcatac attagtaaga gtggcggtac caaaatgtat      180

gcagactcgg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acagccatgt attactgtgc gaaagatcgg      300

gcaacttgta gtggtggtag gtgctactcc ttttactacg gtatggacgt ctggggccaa      360

ggcaccctgg tcaccgtctc ctca                                             384


<210>  16
<211>  1071
<212>  DNA
<213>  Homo sapiens

<400>  16
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctcttcttt cgatttcgat tattatgaaa tgagctgggt ccgccaggct      120

ccaggacaac ggcttgagtg ggttgcatac attagtaaga gtggcggtac caaaatgtat      180

gcagactcgg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acagccatgt attactgtgc gaaagatcgg      300

gcaacttgta gaggtggtcg ctgctactcc ttttactacg gtatggacgt ctggggccaa      360

ggcaccctgg tcaccgtctc ctcagggccc gacaaaactc acacatgccc accgtgccca      420

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      480

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      540

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      600

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      660

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc      720

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc      780

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa      840

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      900

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc      960

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1020

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1071


<210>  17
<211>  1770
<212>  DNA
<213>  Homo sapiens

<400>  17
caagtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatgtg      300

cagtggctgg catacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca      360

ggtggaggcg gttcaggcgg aggtggctct ggcggtggcg gatcagacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      480

agtcagagca ttagtagcta tttaaattgg tatcagcaga agccagggag agcccctgac      540

ctcctgatca atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagtggcagt      600

ggatctggga ccgacttcac tctcaccatc agcagtctcc aacctgaaga ttttgcaact      660

tacttctgtc aacagagtta cagtcttccg ttcactttcg gcggagggac caaggtggag      720

atcaaacgag gtggaggcgg ttcaggcgga ggtggctctg gcggtggcgg atcgagctca      780

gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      840

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      900

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      960

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc     1020

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc     1080

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga     1140

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1200

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1260

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1320

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1380

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1440

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1500

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1560

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1620

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1680

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1740

cagaagagcc tctccctgtc tccgggtaaa                                      1770


<210>  18
<211>  750
<212>  DNA
<213>  Homo sapiens

<400>  18
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctcttcttt cgatttcgat tattatgaaa tgagctgggt ccgccaggct      120

ccaggacaac ggcttgagtg ggttgcatac attagtaaga gtggcggtac caaaatgtat      180

gcagactcgg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acagccatgt attactgtgc gaaagatcgg      300

gcaacttgta gaggtggtcg ctgctactcc ttttactacg gtatggacgt ctggggccaa      360

ggcaccctgg tcaccgtctc ctcaggtgga ggcggttcag gcggaggtgg ctctggcggt      420

ggcggatcac gaactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag      480

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc      540

aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca      600

gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca      660

gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc      720

gtcacaaaga gcttcaacag gggagagtgt                                       750


<210>  19
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, sense

<400>  19
tggtttcgct accgtggccc aggcggccca ggtgcagctg gtg                         43


<210>  20
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, antisense

<400>  20
gtcgccgtgg tggtggtggt ggtggccggc ctggccactt g                           41


<210>  21
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, sense

<400>  21
tggtttcgct accgtggccc agccggccca ggtgcagctg gtg                         43


<210>  22
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, antisense

<400>  22
gtgagttttg tcgggccctg aggagacggt gac                                    33


<210>  23
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, sense

<400>  23
gtgttctaga gccgccacca tggaatggag ctgggtcttt ctcttc                      46


<210>  24
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, antisense

<400>  24
ggagtggaca cctgtagtta ctgacaggaa gaagagaaag ac                          42


<210>  25
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, sense

<400>  25
actacaggtg tccactccca agtgcagctg gtgcag                                 36


<210>  26
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, antisense

<400>  26
ccttggagct cgatccgcca ccgccagagc cacctccgcc tgaaccgcct ccacctcgtt       60

tgatctccac c                                                            71


<210>  27
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, sense

<400>  27
cttacagatg ccagatgtca ggtgcagctg gtgcag                                 36


<210>  28
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, antisense

<400>  28
agagccacct ccgcctgaac cgcctccacc tgaggagacg gtgaccag                    48


<210>  29
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, sense

<400>  29
gtgtaagctt accatgggtg tgcccactca ggtcctgggg ttgctg                      46


<210>  30
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, antisense

<400>  30
acatctggca tctgtaagcc acagcagcag caaccccagg ac                          42


<210>  31
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, sense

<400>  31
tcaggcggag gtggctctgg cggtggcgga tcacgaactg tggctgcacc a                51


<210>  32
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer, antisense

<400>  32
gtgtgaattc attaacactc tcccctgttg aa                                     32


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  33

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  34
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  35
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  36
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Pro Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


