                         SEQUENCE LISTING

<110>  Yeda Research And Development Co. Ltd.
       Shaul, Yosef
       Tsvetkov, Peter
       Adler, Julia
 
<120>  METHODS OF TREATING CANCER

<130>  54655

<150>  US 61/551,970
<151>  2011-10-27

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Psmd1 targeting siRNA sense strand sequence

<400>  1
ctcatattgg gaatgctta                                                    19


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Psmd1 targeting siRNA anti-sense strand sequence

<400>  2
taagcattcc caatatgag                                                    19


<210>  3
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSDM1-shRNAmir stem and loop sequence

<400>  3
tgctgttgac agtgagcgag ctcatattgg gaatgcttat tagtgaagcc acagatgtaa       60

taagcattcc caatatgagc ctgcctactg cctcgga                                97


<210>  4
<211>  2990
<212>  DNA
<213>  Homo sapiens

<400>  4
tgcgcgcgca gcgggccggc agtggcggcg gagatggagg agggaggccg ggacaaggcg       60

ccggtgcagc cccagcagtc tccagcggcg gcccccggcg gcacggacga gaagccgagc      120

ggcaaggagc ggcgggatgc cggggacaag gacaaagaac aggagctgtc tgaagaggat      180

aaacagcttc aagatgaact ggagatgctc gtggaacgac taggggagaa ggatacatcc      240

ctgtatcgac cagcgctgga ggaattgcga aggcagattc gttcttctac aacttccatg      300

acttcagtgc ccaagcctct caaatttctg cgtccacact atggcaaact gaaggaaatc      360

tatgagaaca tggcccctgg ggagaataag cgttttgctg ctgacatcat ctccgttttg      420

gccatgacca tgagtgggga gcgtgagtgc ctcaagtatc ggctagtggg ctcccaggag      480

gaattggcat catggggtca tgagtatgtc aggcatctgg caggagaagt ggctaaggag      540

tggcaggagc tggatgacgc agagaaggtc cagcgggagc ctctgctcac tctggtgaag      600

gaaatcgtcc cctataacat ggcccacaat gcagagcatg aggcttgcga cctgcttatg      660

gaaattgagc aggtggacat gctggagaag gacattgatg aaaatgcata tgcaaaggtc      720

tgcctttatc tcaccagttg tgtgaattac gtgcctgagc ctgagaactc agccctactg      780

cgttgtgccc tgggtgtgtt ccgaaagttt agccgcttcc ctgaagctct gagattggca      840

ttgatgctca atgacatgga gttggtagaa gacatcttca cctcctgcaa ggatgtggta      900

gtacagaaac agatggcatt catgctaggc cggcatgggg tgttcctgga gctgagtgaa      960

gatgtcgagg agtatgagga cctgacagag atcatgtcca atgtacagct caacagcaac     1020

ttcttggcct tagctcggga gctggacatc atggagccca aggtgcctga tgacatctac     1080

aaaacccacc tagagaacaa caggtttggg ggcagtggct ctcaggtgga ctctgcccgc     1140

atgaacctgg cctcctcttt tgtgaatggc tttgtgaatg cagcttttgg ccaagacaag     1200

ctgctaacag atgatggcaa caaatggctt tacaagaaca aggaccacgg aatgttgagt     1260

gcagctgcat ctcttgggat gattctgctg tgggatgtgg atggtggcct cacccagatt     1320

gacaagtacc tgtactcctc tgaggactac attaagtcag gagctcttct tgcctgtggc     1380

atagtgaact ctggggtccg gaatgagtgt gaccctgctc tggcactgct ctcagactat     1440

gttctccaca acagcaacac catgagactt ggttccatct ttgggctagg cttggcttat     1500

gctggctcaa atcgtgaaga tgtcctaaca ctgctgctgc ctgtgatggg agattcaaag     1560

tccagcatgg aggtggcagg tgtcacagct ttagcctgtg gaatgatagc agtagggtcc     1620

tgcaatggag atgtaacttc cactatcctt cagaccatca tggagaagtc agagactgag     1680

ctcaaggata cttatgctcg ttggcttcct cttggactgg gtctcaacca cctggggaag     1740

ggtgaggcca tcgaggcaat cctggctgca ctggaggttg tgtcagagcc attccgcagt     1800

tttgccaaca cactggtgga tgtgtgtgca tatgcaggct ctgggaatgt gctgaaggtg     1860

cagcagctgc tccacatttg tagcgaacac tttgactcca aagagaagga ggaagacaaa     1920

gacaagaagg aaaagaaaga caaggacaag aaggaagccc ctgctgacat gggagcacat     1980

cagggagtgg ctgttctggg gattgccctt attgctatgg gggaggagat tggtgcagag     2040

atggcattac gaacctttgg ccacttgctg agatatgggg agcctacact ccggagggct     2100

gtacctttag cactggccct catctctgtt tcaaatccac gactcaacat cctggatacc     2160

ctaagcaaat tctctcatga tgctgatcca gaagtttcct ataactccat ttttgccatg     2220

ggcatggtgg gcagtggtac caataatgcc cgtctggctg caatgctgcg ccagttagct     2280

caatatcatg ccaaggaccc aaacaacctc ttcatggtgc gcttggcaca gggcctgaca     2340

catttaggga agggcaccct taccctctgc ccctaccaca gcgaccggca gcttatgagc     2400

caggtggccg tggctggact gctcactgtg cttgtctctt tcctggatgt tcgaaacatt     2460

attctaggca aatcacacta tgtattgtat gggctggtgg ctgccatgca gccccgaatg     2520

ctggttacgt ttgatgagga gctgcggcca ttgccagtgt ctgtccgtgt gggccaggca     2580

gtggatgtgg tgggccaggc tggcaagccg aagactatca cagggttcca gacgcataca     2640

accccagtgt tgttggccca cggggaacgg gcagaattgg ccactgagga gtttcttcct     2700

gttaccccca ttctggaagg ttttgttatc cttcggaaga accccaatta tgatctctaa     2760

gtgaccacca ggggctctga actgcagctg atgttatcag caggccatgc atcctgctgc     2820

caagggtgga cacggctgca gacttctggg ggaattgtcg cctcctgctc ttttgttact     2880

gagtgagata aggttgttca ataaagactt ttatccccaa ggaaaaaaaa aaaaaaaaaa     2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                2990


<210>  5
<211>  2174
<212>  DNA
<213>  Homo sapiens

<400>  5
agaaggccca gcgccgggaa ggggtttgca gctgctccgt catcgtgcgg cccgacgcta       60

tctcgcgctc gtgtgcaggc ccggctcggc tcctggtccc cggtgcgagg gttaacgcga      120

ggccccggcc tcggtccccg gactaggccg tgaccccggg tgccatgaag caggagggct      180

cggcgcggcg ccgcggcgcg gacaaggcga aaccgccgcc cggcggagga gaacaagaac      240

ccccaccgcc gccggccccc caggatgtgg agatgaaaga ggaggcagcg acgggtggcg      300

ggtcgacggg ggaggcagac ggcaagacgg cggcggcagc ggctgagcac tcccagcgag      360

agctggacac agtcaccttg gaggacatca aggagcacgt gaaacagcta gagaaagcgg      420

tttcaggcaa ggagccgaga ttcgtgctgc gggccctgcg gatgctgcct tccacatcac      480

gccgcctcaa ccactatgtt ctgtataagg ctgtgcaggg cttcttcact tcaaataatg      540

ccactcgaga ctttttgctc cccttcctgg aagagcccat ggacacagag gctgatttac      600

agttccgtcc ccgcacggga aaagctgcgt cgacacccct cctgcctgaa gtggaagcct      660

atctccaact cctcgtggtc atcttcatga tgaacagcaa gcgctacaaa gaggcacaga      720

agatctctga tgatctgatg cagaagatca gtactcagaa ccgccgggcc ctagaccttg      780

tagccgcaaa gtgttactat tatcacgccc gggtctatga gttcctggac aagctggatg      840

tggtgcgcag cttcttgcat gctcggctcc ggacagctac gcttcggcat gacgcagacg      900

ggcaggccac cctgttgaac ctcctgctgc ggaattacct acactacagc ttgtacgacc      960

aggctgagaa gctggtgtcc aagtctgtgt tcccagagca ggccaacaac aatgagtggg     1020

ccaggtacct ctactacaca gggcgaatca aagccatcca gctggagtac tcagaggccc     1080

ggagaacgat gaccaacgcc cttcgcaagg cccctcagca cacagctgtc ggcttcaaac     1140

agacggtgca caagcttctc atcgtggtgg agctgttgct gggggagatc cctgaccggc     1200

tgcagttccg ccagccctcc ctcaagcgct cactcatgcc ctatttcctt ctgactcaag     1260

ctgtcaggac aggaaaccta gccaagttca accaggtcct ggatcagttt ggggagaagt     1320

ttcaagcaga tgggacctac accctaatta tccggctgcg gcacaacgtg attaagacag     1380

gtgtacgcat gatcagcctc tcctattccc gaatctcctt ggctgacatc gcccagaagc     1440

tgcagttgga tagccccgaa gatgcagagt tcattgttgc caaggccatc cgggatggtg     1500

tcattgaggc cagcatcaac cacgagaagg gctatgtcca atccaaggag atgattgaca     1560

tctattccac ccgagagccc cagctagcct tccaccagcg catctccttc tgcctagata     1620

tccacaacat gtctgtcaag gccatgaggt ttcctcccaa atcgtacaac aaggacttgg     1680

agtctgcaga ggaacggcgt gagcgagaac agcaggactt ggagtttgcc aaggagatgg     1740

cagaagatga tgatgacagc ttcccttgag ctggggggct ggggaggggt agggggaatg     1800

gggacaggct ctttccccct tgggggtccc ctgcccaggg cactgtcccc attttcccac     1860

acacagctca tatgctgcat tcgtgcaggg ggtgggggtg ctgggagcca gccaccctga     1920

cctcccccag ggctcctccc cagccggtga cttactgtac agcaggcagg agggtgggca     1980

ggcaacctcc ccgggcaggg tcctggccag cagtgtggga gcaggagggg aaggatagtt     2040

ctgtgtactc ctttagggag tgggggacta gaactgggat gtcttggctt gtatgttttt     2100

tgaagcttcg attatgattt ttaaacaata aaaagttctc cacagtgaaa aaaaaaaaaa     2160

aaaaaaaaaa aaaa                                                       2174


<210>  6
<211>  1332
<212>  DNA
<213>  Homo sapiens

<400>  6
aattggagga gttgttgtta ggccgtcccg gagacccggt cgggagggag gaaggtggca       60

agatggtgtt ggaaagcact atggtgtgtg tggacaacag tgagtatatg cggaatggag      120

acttcttacc caccaggctg caggcccagc aggatgctgt caacatagtt tgtcattcaa      180

agacccgcag caaccctgag aacaacgtgg gccttatcac actggctaat gactgtgaag      240

tgctgaccac actcacccca gacactggcc gtatcctgtc caagctacat actgtccaac      300

ccaagggcaa gatcaccttc tgcacgggca tccgcgtggc ccatctggct ctgaagcacc      360

gacaaggcaa gaatcacaag atgcgcatca ttgcctttgt gggaagccca gtggaggaca      420

atgagaagga tctggtgaaa ctggctaaac gcctcaagaa ggagaaagta aatgttgaca      480

ttatcaattt tggggaagag gaggtgaaca cagaaaagct gacagccttt gtaaacacgt      540

tgaatggcaa agatggaacc ggttctcatc tggtgacagt gcctcctggg cccagtttgg      600

ctgatgctct catcagttct ccgattttgg ctggtgaagg tggtgccatg ctgggtcttg      660

gtgccagtga ctttgaattt ggagtagatc ccagtgctga tcctgagctg gccttggccc      720

ttcgtgtatc tatggaagag cagcggcagc ggcaggagga ggaggcccgg cgggcagctg      780

cagcttctgc tgctgaggcc gggattgcta cgactgggac tgaagactca gacgatgccc      840

tgctgaagat gaccatcagc cagcaagagt ttggccgcac tgggcttcct gacctaagca      900

gtatgactga ggaagagcag attgcttatg ccatgcagat gtccctgcag ggagcagagt      960

ttggccaggc ggaatcagca gacattgatg ccagctcagc tatggacaca tctgagccag     1020

ccaaggagga ggatgattac gacgtgatgc aggaccccga gttccttcag agtgtcctag     1080

agaacctccc aggtgtggat cccaacaatg aagccattcg aaatgctatg ggctccctgg     1140

cctcccaggc caccaaggac ggcaagaagg acaagaagga ggaagacaag aagtgagact     1200

ggagggaaag ggtagctgag tctgcttagg ggactgcatg ggaagcacgg aatatagggt     1260

tagatgtgtg ttatctgtaa ccattacagc ctaaataaag cttggcaact ttttttcctt     1320

ttttgcttca aa                                                         1332


<210>  7
<211>  1308
<212>  DNA
<213>  Homo sapiens

<400>  7
gtcagccgct gtccccttag ccgcgatgcc gctggagaac ctggaggagg agggtctgcc       60

caagaacccc gacttgcgta tcgcgcagct gcgcttcctg ctcagcctgc ccgagcaccg      120

cggagacgct gccgtgcgcg acgagctgat ggcggccgtc cgcgataaca acatggctcc      180

ttactatgaa gccttgtgca aatccctcga ctggcagata gacgtggacc tactcaataa      240

aatgaagaag gcaaatgaag atgagttgaa gcgtttggat gaggagctgg aagatgcaga      300

gaagaatcta ggagagagcg aaattcgcga tgcaatgatg gcaaaggccg agtacctctg      360

ccggataggt gacaaagagg gagctctgac agcctttcgc aagacatatg acaaaactgt      420

ggccctgggt caccgattgg atattgtatt ctatctcctt aggattggct tattttatat      480

ggataatgat ctcatcacac gaaacacaga aaaggccaaa agcttaatag aagaaggagg      540

agactgggac aggagaaacc gcctaaaagt gtatcagggt ctttattgtg tggctattcg      600

tgatttcaaa caggcagctg aactcttcct tgacactgtt tcaacattta catcctatga      660

actcatggat tataaaacat ttgtgactta tactgtctat gtcagtatga ttgccttaga      720

aagaccagat ctcagggaaa aggtcattaa aggagcagag attcttgaag tgttgcacag      780

tcttccagca gttcggcagt atctgttttc actctatgaa tgccgttact ctgttttctt      840

ccaatcatta gcggttgtgg aacaggaaat gaaaaaggac tggctttttg cccctcatta      900

tcgatactat gtaagagaaa tgagaattca tgcatacagt cagctgctgg aatcatatag      960

gtcattaacc cttggctata tggcagaagc gtttggtgtt ggtgtggaat tcattgatca     1020

ggaactgtcc aggtttattg ctgccgggag actacactgc aaaatagata aagtgaatga     1080

aatagtagaa accaacagac ctgatagcaa gaactggcag taccaagaaa ctatcaagaa     1140

aggagatctg ctactaaaca gagttcaaaa actttccaga gtaattaata tgtaaagcca     1200

tgtaactaac aaaggatttg ctttagagat aattatttgg aatttttata gcttacttca     1260

caatgtgccc aggtcagctg tataaaataa atactgcatt gttgtttc                  1308


<210>  8
<211>  1686
<212>  DNA
<213>  Homo sapiens

<400>  8
gggagcggaa gaaggaggcc gcgcgagggc tgacgaaccg gaagaagagg aactgggcct       60

gaaagggtac cggtgaccgc tactgctgcc ggtgtttgcg tgtggcaggg agccaggcct      120

ggcgagcggg gtgtgtcgcg atgccggagc tggcagtgca gaaggtggtg gtccaccccc      180

tggtgctgct cagtgtggtg gatcatttca accgaatcgg caaggttgga aaccagaagc      240

gtgttgttgg tgtgcttttg gggtcatggc aaaagaaagt acttgatgta tcgaacagtt      300

ttgcagttcc ttttgatgaa gatgacaaag acgattctgt atggttttta gaccatgatt      360

atttggaaaa catgtatgga atgtttaaga aagtcaatgc cagggaaaga atagttggct      420

ggtaccacac aggccctaaa ctacacaaga atgacattgc catcaacgaa ctcatgaaaa      480

gatactgtcc taattccgta ttggtcatca ttgatgtgaa gccgaaggac ctagggctgc      540

ctacagaagc gtacatttca gtggaagaag tccatgatga tggaactcca acctcgaaaa      600

catttgaaca cgtgaccagt gaaattggag cagaggaagc tgaggaagtt ggagttgaac      660

acttgttacg agatatcaaa gacacgacgg tgggcactct gtcccagcgg atcacaaacc      720

aggtccatgg tttgaaggga ctgaactcca agcttctgga tatcaggagc tacctggaaa      780

aagtcgccac aggcaagctg cccatcaacc accagatcat ctaccagctg caggacgtct      840

tcaacctgct gccagatgtc agcctgcagg agttcgtcaa ggccttttac ctgaagacca      900

atgaccagat ggtggtagtg tacttggcct cgctgatccg ttccgtggtc gccctgcaca      960

acctcatcaa caacaagatt gccaaccggg atgcagagaa gaaagaaggg caggagaaag     1020

aagagagcaa aaaggatagg aaagaggaca aggagaaaga taaagataag gaaaagagtg     1080

atgtaaagaa agaggagaaa aaggagaaaa agtaaaacat gtattaaata gcttttttaa     1140

tttgtaaatt aaaatcttac aaactaaatc agtgtgctgc tagagggttc tttttcactt     1200

gacatgctta ttagaaagct gacccaacaa gagctctctg cctccggtca ctcttgctgt     1260

ggtgctacgt ggaagtgaat ggagactgat ctcaaatctg aactgcagct ttcgctgctg     1320

tgagttgggg atatgatagt cagctcaggc ttcagattgt atgagaaaaa tgaagagaag     1380

tcaacaaata ttttggtact cttcattcat ttatctctaa aaccaggagt tgaattttcc     1440

tcatcttgaa agactcttgg ggtctgtttc tggtatttta caaaattgct aagtggaatg     1500

catgaattgc attatgttct ctggtaacac gtagagttca gacccttctg aactctgttg     1560

ataataccac accatgttct ggacccatag ctctggcatc ctcaggggtt gtgatccagc     1620

tccatatatt gtttaccttc aaagatacaa ttaaatggct tgatttttaa aaaaaaaaaa     1680

aaaaaa                                                                1686


<210>  9
<211>  1556
<212>  DNA
<213>  Homo sapiens

<400>  9
ccaacttccg gtcaccatct tgagtgacga cagaggcgga gctccaactg acatgttcat       60

taagggcagg gctccgaggg cgccacctcg agagcgacgg cgggctaccc ggggcgggct      120

gaggcaggtt gtagccccgc cccgggcctt gggctccacc tctcggcccc acttccgccg      180

ggcaagcgtt tgtaggcggc gctgccgtaa atcaggcggt ctgcttgccg catcacgcaa      240

gatggcggcc gcggcggtga acggggcggc aggcttctcg agctccgggc ccgcggcaac      300

ctcgggcgct gttctgcagg ccgcgaccgg catgtacgag caactcaagg gcgagtggaa      360

ccgtaaaagc cccaatctta gcaagtgcgg ggaagagctg ggtcgactca agctagttct      420

tctggagctc aacttcttgc caaccacagg gaccaagctg accaaacagc agctaattct      480

ggcccgtgac atactggaga tcggggccca atggagcatc ctacgcaagg acatcccctc      540

cttcgagcgc tacatggccc agctcaaatg ctactacttt gattacaagg agcagctccc      600

cgagtcagcc tatatgcacc agctcttggg cctcaacctc ctcttcctgc tgtcccagaa      660

ccgggtggct gagttccaca cggagttgga gcggctgcct gccaaggaca tacagaccaa      720

tgtctacatc aagcacccag tgtccctgga gcaatacctg atggagggca gctacaacaa      780

agtgttcctg gccaagggta acatccccgc cgagagctac accttcttca ttgacatcct      840

gctcgacact atcagggatg agatcgctgg gtgcatcgag aaggcctacg agaaaatcct      900

tttcactgag gccacccgga tcctcttctt caacacaccc aaaaagatga cagactacgc      960

caagaagcga gggtgggtcc tgggccccaa caactactac agttttgcca gccagcagca     1020

gaagccggaa gacaccacca ttccctccac agaactggcc aaacaggtca tcgagtatgc     1080

ccggcagctg gagatgatcg tctgagcccc ccgggcactg ggtggggcag ggcacgagtt     1140

atttaaaaca gttacactgc agggtttcgc ccaataaagg tggactgaca ttccctcttc     1200

caggcccttg tctccccagt tgggacggca gagagacaag ttcttatatc tgaagaactt     1260

ggaggttttg gggcattcag gagttggaga tagcctccaa ctgggtcagc ctctgtctgg     1320

tgggcattgc tcagggtctc aaacatggac gcccactgtg gggccccagc agcactgtgg     1380

cctgcaggag ggcatggccc caggtagggg gactgttcta gccagctgtg gacacatagg     1440

aatgctggac cagggtacca gattttttca acaaaggggg tgaagtgtcc tactaaaaag     1500

aataaatgtt ggcagtgaat taaacaattt ttcaaatgaa aaaaaaaaaa aaaaaa         1556


<210>  10
<211>  1814
<212>  DNA
<213>  Homo sapiens

<400>  10
ctgagcgggt gcgcgggcaa cttccggtgt gggtgacgag tggtggccga agcaggggga       60

cagcaaggga cgctcaggcg gggaccatgg cggacggcgg ctcggagcgg gctgacgggc      120

gcatcgtcaa gatggaggtg gactacagcg ccacggtgga tcagcgccta cccgagtgtg      180

cgaagctagc caaggaagga agacttcaag aagtcattga aacccttctc tctctggaaa      240

agcagactcg tactgcttcc gatatggtat cgacatcccg tatcttagtt gcagtagtga      300

agatgtgcta tgaggctaaa gaatgggatt tacttaatga aaatattatg cttttgtcca      360

aaaggcggag tcagttaaaa caagctgttg ccaaaatggt tcaacagtgc tgtacttatg      420

ttgaggaaat cacagacctt cctatcaaac ttcgattaat tgatactcta cgaatggtta      480

ccgaaggcaa gatttatgtt gaaattgagc gtgcgcgact gactaaaaca ttagcaacta      540

taaaagaaca aaatggtgat gtgaaagagg cagcctccat tttacaggag ttacaggtgg      600

aaacctacgg gtcaatggaa aagaaagagc gagtggaatt tattttggag caaatgaggc      660

tctgcctagc tgtgaaggat tacattcgaa cacaaatcat cagcaagaaa attaacacca      720

aatttttcca ggaagaaaat acagagaaat taaagttgaa gtactataat ttaatgattc      780

agctggatca acatgaggga tcctatttgt ctatttgtaa gcactacaga gcaatatatg      840

atactccctg tatacaggca gaaagtgaaa aatggcagca ggctctgaag agtgttgtac      900

tctatgttat cctggctcct tttgacaatg aacagtcaga tttggttcac cgaataagtg      960

gtgacaagaa gttagaagaa attcccaaat acaaggatct tttaaagctt tttaccacaa     1020

tggagttgat gcgttggtcc acacttgttg aggactatgg aatggaatta agaaaaggtt     1080

cccttgagag tcctgcaacg gatgtttttg gttctacaga ggaaggtgaa aaaaggtgga     1140

aagacttgaa gaacagagtt gttgaacata atattagaat aatggccaag tattatactc     1200

ggataacaat gaaaaggatg gcacagcttc tggatctatc tgttgatgag tccgaagcct     1260

ttctctcaaa tctagtagtt aacaagacca tctttgctaa agtagacaga ttagcaggaa     1320

ttatcaactt ccagagaccc aaggatccaa ataatttatt aaatgactgg tctcagaaac     1380

tgaactcatt aatgtctctg gttaacaaaa ctacgcatct catagccaaa gaggagatga     1440

tacataatct acaataaggg tcttagtgct ttagaaaaaa gttaaaattg gaagtcatta     1500

aaaaaagact gttataatgg tgtatatgtt ggggtttttt ttctaagctt ctttgtctta     1560

aattttaaaa tagtgaatat gtttgagact ccctttgacc tttcagttcc ccaagttcat     1620

tgttaacttt gcatttgcaa ttggtgcaaa aatacagatt tctgtcgtct gaatacacaa     1680

aaagttgtgt cataacttac ccagatatgt ttttctatca tttgaaacct ttttagctac     1740

tgtttgtttt cattcaacta acaaacatat tccaataata aaagcagtat atacataaaa     1800

aaaaaaaaaa aaaa                                                       1814


<210>  11
<211>  3236
<212>  DNA
<213>  Homo sapiens

<400>  11
ggggtcctgg cgagaagcga gccggcggcc tgaggaggcg actgactgag cagcgcaccc       60

ggggagcaag gaggcgcggt gaactgagcg gcccctgagc tgacagatac actgcgcagc      120

tggaacggcg agcgagccga cgggcgagtg aggggcgcag ccatgatcac ctcggccgct      180

ggaattattt ctcttctgga tgaagatgaa ccacagctta aggaatttgc actacacaaa      240

ttgaatgcag ttgttaatga cttctgggca gaaatttccg agtccgtaga caaaatagag      300

gttttatacg aagatgaagg tttccggagt cggcagtttg cagccttagt ggcatctaaa      360

gtattttatc acctgggggc ttttgaggag tctctgaatt atgctcttgg agcaggggac      420

ctcttcaatg tcaatgataa ctctgaatat gtggaaacta ttatagcaaa atgcattgat      480

cactacacca aacaatgtgt ggaaaatgca gatttgcctg aaggagaaaa aaaaccaatt      540

gaccagagat tggaaggcat cgtaaataaa atgttccagc gatgtctaga tgatcacaag      600

tataaacagg ctattggcat tgctctggag acacgaagac tggacgtctt tgaaaagacc      660

atactggagt cgaatgatgt cccaggaatg ttagcttata gccttaagct ctgcatgtct      720

ttaatgcaga ataaacagtt tcggaataaa gtactaagag ttctagttaa aatctacatg      780

aacttggaga aacctgattt catcaatgtt tgtcagtgct taattttctt agatgatcct      840

caggctgtga gtgatatctt agagaaactg gtaaaggaag acaacctcct gatggcatat      900

cagatttgtt ttgatttgta tgaaagtgct agccagcagt ttttgtcatc tgtaatccag      960

aatcttcgaa ctgttggcac ccctattgct tctgtgcctg gatccactaa tacgggtact     1020

gttccgggat cagagaaaga cagtgactcg atggaaacag aagaaaagac aagcagtgca     1080

tttgtaggaa agacaccaga agccagtcca gagcctaagg accagacttt gaaaatgatt     1140

aaaattttaa gtggtgaaat ggctattgag ttacatctgc agttcttaat acgaaacaat     1200

aatacagacc tcatgattct aaaaaacaca aaggatgcag tacggaattc tgtatgtcat     1260

actgcaaccg ttatagcaaa ctcttttatg cactgtggga caaccagtga ccagtttctt     1320

agagataatt tggaatggtt agccagagcc actaactggg caaaatttac tgctacagcc     1380

agtttgggtg taattcataa gggtcatgaa aaagaagcat tacagttaat ggcaacatac     1440

cttcccaagg atacttctcc aggatcagcc tatcaggaag gtggaggtct ctatgcacta     1500

ggtcttattc atgccaatca tggtggtgat ataattgact atctgcttaa tcagcttaag     1560

aacgccagca atgatatcgt tagacacggt ggcagtctgg gccttggttt ggcagccatg     1620

ggaactgcac gtcaagatgt ttatgatttg ctaaaaacaa acctttatca ggatgatgca     1680

gtaacagggg aagcagctgg cctggcccta ggtttggtta tgttgggctc taaaaatgct     1740

caggctattg aggacatggt tggttatgca caagaaactc aacatgagaa gattctgcgt     1800

ggtcttgcag ttggcatagc tttagtaatg tatgggagga tggaagaggc tgatgctctc     1860

attgaatctc tctgtcgtga caaggaccca attcttcgaa ggtctggaat gtatactgta     1920

gccatggctt attgtggctc tggtaacaac aaagcaattc gacgcctgct acatgttgct     1980

gtaagtgatg ttaatgatga tgtcaggagg gcagcagtag aatcacttgg gttcattcta     2040

ttcagaaccc ctgaacagtg cccaagtgtt gtctctttgt tgtcagagag ttacaaccct     2100

catgtgcgct acggagctgc aatggccttg gggatatgct gtgctggtac aggaaacaag     2160

gaagccatta atttgctaga accaatgaca aacgaccccg tgaactacgt gaggcaaggg     2220

gcactcatag cttcagctct catcatgatc cagcagactg aaatcacttg tccaaaggtg     2280

aatcagttca gacagctgta ttccaaagtc atcaatgata agcatgatga tgtcatggcc     2340

aagtttggcg ctattctggc ccagggcata ctggatgcag gtggtcataa tgtcacaatc     2400

tccttgcagt ccaggactgg gcatactcat atgccttctg tggttggcgt ccttgtattt     2460

acccagtttt ggttctggtt tcctctttca cacttcctgt cattggctta tacccctacc     2520

tgtgtcattg gccttaacaa ggacttaaag gtttctactg ctgtattatc tataactgcc     2580

aaggctaaaa agaaggaaaa agaaaaggaa aaaaaggagg aggagaaaat ggaagtggat     2640

gaggcagaga aaaaggagga aaaagagaag aaaaaagaac ctgagccaaa cttccagtta     2700

ttggataacc cagcccgagt tatgcctgcc cagcttaagg tcctaaccat gccggagacc     2760

tgtagatacc agcctttcaa accactctct attggaggca tcatcattct gaaggatacc     2820

agtgaagaca ttgaggagct ggtggaacct gtggcagcac atggcccaaa aatcgaggag     2880

gaggaacaag agccagaacc cccagaacca tttgagtata ttgatgatta agggccagag     2940

gatctcactt gcttatctga agaagattgt ccaggctcat attgggaatg cttatgagga     3000

aattcatgcc gagacctgct attcaatgca tgtatcgttg cctctgcact gacctgaaga     3060

accctgtctc caagtctttg gttgaagaga agatatatga ctgttgagtg tgctctttca     3120

cagaacttgg ttttcaaata aatataagat ctccagatgg acaagacatt tgtttttcag     3180

cctgggtttt taataaatgt atctaatcct ccccacacca tgaaatgcct aaaaaa         3236


<210>  12
<211>  3329
<212>  DNA
<213>  Homo sapiens

<400>  12
ggggtcctgg cgagaagcga gccggcggcc tgaggaggcg actgactgag cagcgcaccc       60

ggggagcaag gaggcgcggt gaactgagcg gcccctgagc tgacagatac actgcgcagc      120

tggaacggcg agcgagccga cgggcgagtg aggggcgcag ccatgatcac ctcggccgct      180

ggaattattt ctcttctgga tgaagatgaa ccacagctta aggaatttgc actacacaaa      240

ttgaatgcag ttgttaatga cttctgggca gaaatttccg agtccgtaga caaaatagag      300

gttttatacg aagatgaagg tttccggagt cggcagtttg cagccttagt ggcatctaaa      360

gtattttatc acctgggggc ttttgaggag tctctgaatt atgctcttgg agcaggggac      420

ctcttcaatg tcaatgataa ctctgaatat gtggaaacta ttatagcaaa atgcattgat      480

cactacacca aacaatgtgt ggaaaatgca gatttgcctg aaggagaaaa aaaaccaatt      540

gaccagagat tggaaggcat cgtaaataaa atgttccagc gatgtctaga tgatcacaag      600

tataaacagg ctattggcat tgctctggag acacgaagac tggacgtctt tgaaaagacc      660

atactggagt cgaatgatgt cccaggaatg ttagcttata gccttaagct ctgcatgtct      720

ttaatgcaga ataaacagtt tcggaataaa gtactaagag ttctagttaa aatctacatg      780

aacttggaga aacctgattt catcaatgtt tgtcagtgct taattttctt agatgatcct      840

caggctgtga gtgatatctt agagaaactg gtaaaggaag acaacctcct gatggcatat      900

cagatttgtt ttgatttgta tgaaagtgct agccagcagt ttttgtcatc tgtaatccag      960

aatcttcgaa ctgttggcac ccctattgct tctgtgcctg gatccactaa tacgggtact     1020

gttccgggat cagagaaaga cagtgactcg atggaaacag aagaaaagac aagcagtgca     1080

tttgtaggaa agacaccaga agccagtcca gagcctaagg accagacttt gaaaatgatt     1140

aaaattttaa gtggtgaaat ggctattgag ttacatctgc agttcttaat acgaaacaat     1200

aatacagacc tcatgattct aaaaaacaca aaggatgcag tacggaattc tgtatgtcat     1260

actgcaaccg ttatagcaaa ctcttttatg cactgtggga caaccagtga ccagtttctt     1320

agagataatt tggaatggtt agccagagcc actaactggg caaaatttac tgctacagcc     1380

agtttgggtg taattcataa gggtcatgaa aaagaagcat tacagttaat ggcaacatac     1440

cttcccaagg atacttctcc aggatcagcc tatcaggaag gtggaggtct ctatgcacta     1500

ggtcttattc atgccaatca tggtggtgat ataattgact atctgcttaa tcagcttaag     1560

aacgccagca atgatatcgt tagacacggt ggcagtctgg gccttggttt ggcagccatg     1620

ggaactgcac gtcaagatgt ttatgatttg ctaaaaacaa acctttatca ggatgatgca     1680

gtaacagggg aagcagctgg cctggcccta ggtttggtta tgttgggctc taaaaatgct     1740

caggctattg aggacatggt tggttatgca caagaaactc aacatgagaa gattctgcgt     1800

ggtcttgcag ttggcatagc tttagtaatg tatgggagga tggaagaggc tgatgctctc     1860

attgaatctc tctgtcgtga caaggaccca attcttcgaa ggtctggaat gtatactgta     1920

gccatggctt attgtggctc tggtaacaac aaagcaattc gacgcctgct acatgttgct     1980

gtaagtgatg ttaatgatga tgtcaggagg gcagcagtag aatcacttgg gttcattcta     2040

ttcagaaccc ctgaacagtg cccaagtgtt gtctctttgt tgtcagagag ttacaaccct     2100

catgtgcgct acggagctgc aatggccttg gggatatgct gtgctggtac aggaaacaag     2160

gaagccatta atttgctaga accaatgaca aacgaccccg tgaactacgt gaggcaaggg     2220

gcactcatag cttcagctct catcatgatc cagcagactg aaatcacttg tccaaaggtg     2280

aatcagttca gacagctgta ttccaaagtc atcaatgata agcatgatga tgtcatggcc     2340

aagtttggcg ctattctggc ccagggcata ctggatgcag gtggtcataa tgtcacaatc     2400

tccttgcagt ccaggactgg gcatactcat atgccttctg tggttggcgt ccttgtattt     2460

acccagtttt ggttctggtt tcctctttca cacttcctgt cattggctta tacccctacc     2520

tgtgtcattg gccttaacaa ggacttaaag atgccgaaag ttcagtataa atcgaactgt     2580

aaaccatcca catttgcata tcctgcccct ctggaagtac caaaagaaaa agaaaaggaa     2640

aaggtttcta ctgctgtatt atctataact gccaaggcta aaaagaagga aaaagaaaag     2700

gaaaaaaagg aggaggagaa aatggaagtg gatgaggcag agaaaaagga ggaaaaagag     2760

aagaaaaaag aacctgagcc aaacttccag ttattggata acccagcccg agttatgcct     2820

gcccagctta aggtcctaac catgccggag acctgtagat accagccttt caaaccactc     2880

tctattggag gcatcatcat tctgaaggat accagtgaag acattgagga gctggtggaa     2940

cctgtggcag cacatggccc aaaaatcgag gaggaggaac aagagccaga acccccagaa     3000

ccatttgagt atattgatga ttaagggcca gaggatctca cttgcttatc tgaagaagat     3060

tgtccaggct catattggga atgcttatga ggaaattcat gccgagacct gctattcaat     3120

gcatgtatcg ttgcctctgc actgacctga agaaccctgt ctccaagtct ttggttgaag     3180

agaagatata tgactgttga gtgtgctctt tcacagaact tggttttcaa ataaatataa     3240

gatctccaga tggacaagac atttgttttt cagcctgggt ttttaataaa tgtatctaat     3300

cctccccaca ccatgaaatg cctaaaaaa                                       3329


<210>  13
<211>  3914
<212>  DNA
<213>  Homo sapiens

<400>  13
tttccgggtg tgtgtttccg gcgtcggcgg ccgcggccgg ggacggtgtg agagcggtaa       60

gatggcggcg gcggcggtgg tggagttcca gagagcccag tctctactca gcaccgaccg      120

ggaggcctcc atcgacatcc tccactccat cgtgaagcgt gacattcagg aaaacgatga      180

agaggcagtg caagtcaaag agcagagcat cctggaactg ggatctctcc tggcaaagac      240

tggacaagct gcagagcttg gaggactcct gaagtatgta cgacccttct tgaattccat      300

cagcaaggct aaagcagctc gcctggtccg atctcttctt gatctgtttc ttgatatgga      360

agcagctaca gggcaggagg tcgagctgtg tttagagtgc atcgaatggg ccaagtcaga      420

gaaaagaact ttcttacgcc aagctttgga ggcaagactg gtgtctttgt actttgatac      480

caagaggtac caggaagcat tgcatttggg ttctcagctg ctgcgggagt tgaaaaagat      540

ggacgacaaa gctcttttgg tggaagtaca gcttttagaa agcaaaacat accatgccct      600

gagcaacctg ccgaaagccc gagctgcctt aacttctgct cgaaccacag caaatgccat      660

ctactgcccc cctaaattgc aggccacctt ggacatgcag tcgggtatta tccatgcagc      720

agaagagaag gactggaaaa ctgcgtactc atacttctat gaggcatttg agggttatga      780

ctccatcgac agccccaagg ccatcacatc tctgaagtac atgttgctgt gcaaaatcat      840

gctcaacacc ccagaagatg tccaggcttt ggtgagcggg aagcttgcac ttcggtatgc      900

agggaggcag acagaagcat taaaatgcgt ggctcaggct agcaagaaca gatcactggc      960

agattttgaa aaggctctga cagattaccg ggcagagctc cgggatgacc caatcatcag     1020

cacacacttg gccaagttgt atgataactt actagaacag aatctgatcc gagtcattga     1080

gcctttttcc agagtacaga ttgaacacat atctagtctc atcaaactct ccaaggccga     1140

cgtggaaagg aaattatcac agatgattct tgacaagaaa tttcatggga ttttggacca     1200

gggggagggt gtcctgatta ttttcgatga acccccagta gataaaactt acgaagctgc     1260

tctggaaaca attcagaaca tgagcaaagt agtggattcc ctctacaaca aagccaagaa     1320

actgacatag agttggatct gtagcggtcc tttggagagt gtgtgtggcg ggagagtgaa     1380

accttggggg aaaatgctag gagattcttt tttctttttg ttctactttt cgctcggaaa     1440

gtttttaaat cctcatttgg tgcatctgta ttccagccaa taggtgtgcc agttttcatg     1500

taatctttac tggcccaact tgggagtggg gaaattgctt aaaaaaaaag aaaaagaaaa     1560

aaaaaaagat tattctaaat aaaaggaaaa aggcttacac tacctaaagc tgtgctctct     1620

gcctcctggg agagggccgc aaagccaggc accccgccaa ccactggggg tcctaatcca     1680

cctgctgggc atcacctctc ctcctcctca gaattgggtg tttgctgacc atcaaaagca     1740

atgacttttt attctgtttg tactgaacca aaacaaacaa ctgtgtatag actgctgttt     1800

tcttttttat ttgaaatgag gcattttggt gttctttccc ctaccatacg gcctgtctgc     1860

ccttccctcc ccacattggc tccagcagag tagccgaagg tcctgccgcc gccgccacca     1920

ccaccaccac tgcagcaaca acagcagcag cagcagcagc gcctgcatag ctccactctg     1980

acctgtgaag gaatggggat gaggccagga gctagtgtct accacggcca cacagggagc     2040

agtgtgggcc cttagccccc aaggggcctg ctatgcatgt ggcttttttt ttttttttaa     2100

acacagtaaa ctagattagt cgtcagtgtt ttaattgccc ctcttctcct ctcctgcatt     2160

cctctcctct cttctttcct ctctgtccct tctctttccc ctctcaacca ggagaccatc     2220

atgtctctct gccttcctcc tctcccctcc aggggagtca ggctgtctgt gaaagccatg     2280

agcttctctc cctctcccac tcctcctctc ctactttcag atggatttat tcctttttta     2340

aacaatgaac atcggaaatg agactgtggg gtgtggtttc tctctctctt ttttttttaa     2400

ttttctttgt tgggtttttg agcaacctca tgtccccttc ccagggagct ttttaattta     2460

cctcttagaa ctcaagtgga tgggaagtag agcactatgt gtcagtatgc tttgttttct     2520

gacacgatta cacagcgagg ctttaatgcc atttgggtag gtgagcttct gcacttctgt     2580

tgtgctgaac tgtattttct tctctcatct cctctttgtc tttttctctt ttcctctcct     2640

tcctgccttc ttctgctggc ctccttttct ctttctttac cttccttgga ttatccttcc     2700

aggttttcat aataaattta tattttgtaa aaggattttg ttgtaccagg ttttgcatcc     2760

tcactgaatc tgactggctt ttattttcct ctccaaaatc aggtttttgt tctcaacatc     2820

tttccccatc atgtctagtc actgttttgg ttttggcacc atcagtatca aatgtacaaa     2880

cggttcttgc taaccaacac caggtatatc tgatgttcag atgagttcca ataaaaataa     2940

tttttttttt tttcaaaagg tgtctttttc ttgagtgctg gagggcttcc aagcaagtcc     3000

agacagctct gtgtggcccc acactagtct agctctcatc tggccaaagc tgttatctca     3060

tttgtgtaat gggagtcctt aaggtaaatt tggggtccaa acttggaggg ctttgggggc     3120

aagaaagttg gtgtgtgagt tctgaggttg gaaatgagtt caggtgtctt cttccagggc     3180

agcatggtcc agtgagcaca tgtaagtttg ggcagtagat cctctgagcc tactttctct     3240

tctactcagt gaggatgctg cttccttggc aggtgattgt gatgtgaagc ttagtaagtc     3300

atagacgtgc aggtgtctgg agagtcctga catgcagttg tggtttcgtt tccttttgga     3360

atcttcaaag gcagcgattt tcatattgcc tcacaccctg gcgggggcgg ggggctctgg     3420

gaccactggg ggacctgcta aatcctcttc agtctgagca gttcagccat tgtcagtttt     3480

agtattgtgt ctctgtattt cacttgcaga aagagctttg cttctataaa ggactttaaa     3540

aagtactcca aagagatcta gttttggagt agaggggaga tgttttctca aacttagggc     3600

agtcctgaga tgctcaggca gtagcccttt tctcagttcc ctttgcgggt cttggtcaga     3660

tgatgccctc tagacccgtg ctgtccaata tgtagccgct agccatgtgc agctgtcagg     3720

cccttgcaac gtggctggtt cgagctgtga tacactgcaa gtgtaaacac aaaccagact     3780

tcgaaggctt agtatgataa caaaagaaaa ggagtgtaaa atatgtcaat aactttttta     3840

tatatgtgtt gaaatatttt gggtattggg ttaaataaaa tatattatta aaattcaaaa     3900

aaaaaaaaaa aaaa                                                       3914


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Psmd6 targeting shRNA anti-sense strand sequence

<400>  14
aataaacctg gacagttcct g                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Psmd6 targeting shRNA anti-sense strand sequence

<400>  15
aatgacctat atgattccag c                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Psmd11 targeting shRNA anti-sense strand sequence

<400>  16
ataatacccg actgcatgtc c                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Psmd11 targeting shRNA anti-sense strand sequence

<400>  17
ataatttcct ttccacgtcg g                                                 21


<210>  18
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PSMD6 targeting shRNA sequence

<400>  18
ccggcaggaa ctgtccaggt ttattctcga gaataaacct ggacagttcc tgttttttg        59


<210>  19
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PSMD6 targeting shRNA sequence

<400>  19
ccgggctgga atcatatagg tcattctcga gaatgaccta tatgattcca gcttttttg        59


<210>  20
<211>  58
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PSMD11 targeting shRNA sequence

<400>  20
ccggggacat gcagtcgggt attatctcga gataataccc gactgcatgt cctttttg         58


<210>  21
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PSMD11 targeting shRNA sequence

<400>  21
ccggccgacg tggaaaggaa attatctcga gataatttcc tttccacgtc ggttttt          57


