                         SEQUENCE LISTING

<110>  New York University
       Johns Hopkins University
       Cardozo, Timothy J.
       Bosch, Jurgen
       Nemetski, Sondra M.
 
<120>  SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME 
       INHIBITORS

<130>  29527.1031

<150>  61/551,269
<151>  2011-10-25

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  PRT
<213>  artificial

<220>
<223>  Adolase consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(17)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (54)..(56)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (105)..(107)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (120)..(120)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (161)..(162)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (174)..(175)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (183)..(183)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (189)..(189)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (203)..(203)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (205)..(205)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (211)..(211)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (218)..(219)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (225)..(227)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (229)..(229)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (246)..(246)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (248)..(249)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (252)..(252)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (254)..(254)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (256)..(256)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (259)..(259)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (265)..(265)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (271)..(271)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (286)..(286)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (289)..(289)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (294)..(294)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (296)..(296)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (318)..(318)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (321)..(321)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (327)..(328)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (331)..(332)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (336)..(336)
<223>  X is any amino acid

<220>
<221>  misc_feature
<222>  (356)..(357)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (361)..(361)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (363)..(369)
<223>  X is any amino acid

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Leu Pro Xaa 
1               5                   10                  15      


Xaa Val Ala Xaa Glu Xaa Ala Xaa Thr Ala Xaa Lys Leu Val Xaa Xaa 
            20                  25                  30          


Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr Gln Thr Ile Lys Lys 
        35                  40                  45              


Arg Phe Asp Asn Ile Xaa Xaa Xaa Asn Thr Xaa Glu Asn Arg Ala Xaa 
    50                  55                  60                  


Tyr Arg Asp Leu Leu Phe Gly Thr Lys Gly Leu Gly Lys Phe Ile Ser 
65                  70                  75                  80  


Gly Ala Ile Leu Phe Glu Glu Thr Leu Phe Gln Lys Asn Glu Ala Gly 
                85                  90                  95      


Val Pro Xaa Val Asn Leu Leu His Xaa Xaa Xaa Ile Ile Pro Gly Ile 
            100                 105                 110         


Lys Val Asp Lys Gly Leu Val Xaa Ile Pro Cys Thr Asp Xaa Glu Lys 
        115                 120                 125             


Ser Thr Gln Gly Leu Asp Gly Leu Ala Glu Arg Cys Lys Glu Tyr Tyr 
    130                 135                 140                 


Lys Ala Gly Ala Arg Phe Ala Lys Trp Arg Xaa Val Leu Val Ile Asp 
145                 150                 155                 160 


Xaa Xaa Lys Gly Lys Pro Thr Asp Leu Ser Ile Xaa Glu Xaa Xaa Trp 
                165                 170                 175     


Gly Leu Ala Arg Tyr Ala Xaa Ile Cys Gln Gln Asn Xaa Leu Val Pro 
            180                 185                 190         


Ile Val Glu Pro Glu Ile Leu Ala Asp Gly Xaa His Xaa Ile Glu Val 
        195                 200                 205             


Cys Ala Xaa Val Thr Gln Lys Val Leu Xaa Xaa Val Phe Lys Ala Leu 
    210                 215                 220                 


Xaa Xaa Xaa Gly Xaa Leu Leu Glu Gly Ala Leu Leu Lys Pro Asn Met 
225                 230                 235                 240 


Val Thr Ala Gly Tyr Xaa Cys Xaa Xaa Lys Thr Xaa Thr Xaa Asp Xaa 
                245                 250                 255     


Gly Phe Xaa Thr Val Arg Thr Leu Xaa Arg Thr Val Pro Pro Xaa Leu 
            260                 265                 270         


Pro Gly Val Val Phe Leu Ser Gly Gly Gln Ser Glu Glu Xaa Ala Ser 
        275                 280                 285             


Xaa Asn Leu Asn Ser Xaa Asn Xaa Leu Gly Pro His Pro Trp Ala Leu 
    290                 295                 300                 


Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser Val Leu Xaa Thr Trp 
305                 310                 315                 320 


Xaa Gly Lys Lys Glu Asn Xaa Xaa Lys Ala Xaa Xaa Val Leu Leu Xaa 
                325                 330                 335     


Arg Ala Glu Ala Asn Ser Leu Ala Thr Tyr Gly Lys Tyr Lys Gly Gly 
            340                 345                 350         


Ala Gly Gly Xaa Xaa Ala Gly Ala Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa 
    


<210>  2
<211>  365
<212>  PRT
<213>  Plasmodium berghei

<400>  2

Cys Ala Glu Tyr Lys Asn Ala Pro Met Lys Leu Pro Lys Glu Val Ala 
1               5                   10                  15      


Gln Glu Leu Ala Glu Thr Ala Lys Lys Leu Val Ala Ala Gly Lys Gly 
            20                  25                  30          


Ile Leu Ala Ala Asp Glu Ser Thr Gln Thr Ile Lys Lys Arg Phe Asp 
        35                  40                  45              


Asn Ile Lys Ile Glu Asn Thr Val Glu Asn Arg Ala Ser Tyr Arg Asp 
    50                  55                  60                  


Leu Leu Phe Gly Thr Lys Gly Leu Gly Lys Phe Ile Ser Gly Ala Ile 
65                  70                  75                  80  


Leu Phe Glu Glu Thr Leu Phe Gln Lys Asn Glu Ala Gly Val Pro Leu 
                85                  90                  95      


Val Asn Leu Leu His Asp Glu Gly Ile Ile Pro Gly Ile Lys Val Asp 
            100                 105                 110         


Lys Gly Leu Val Ser Ile Pro Cys Thr Asp Asp Glu Lys Ser Thr Gln 
        115                 120                 125             


Gly Leu Asp Gly Leu Ala Glu Arg Cys Lys Glu Tyr Tyr Lys Ala Gly 
    130                 135                 140                 


Ala Arg Phe Ala Lys Trp Arg Ala Val Leu Val Ile Asp Pro Ala Lys 
145                 150                 155                 160 


Gly Lys Pro Thr Asp Leu Ser Ile Gln Glu Val Ser Trp Gly Leu Ala 
                165                 170                 175     


Arg Tyr Ala Ser Ile Cys Gln Gln Asn Lys Leu Val Pro Ile Val Glu 
            180                 185                 190         


Pro Glu Ile Leu Ala Asp Gly Ala His Thr Ile Glu Val Cys Ala Thr 
        195                 200                 205             


Val Thr Gln Lys Val Leu Ala Ser Val Phe Lys Ala Leu His Asp Asn 
    210                 215                 220                 


Gly Val Leu Leu Glu Gly Ala Leu Leu Lys Pro Asn Met Val Thr Ala 
225                 230                 235                 240 


Gly Tyr Asp Cys Thr Glu Lys Thr Lys Thr Asp Asp Ile Gly Phe Phe 
                245                 250                 255     


Thr Val Arg Thr Leu Arg Arg Thr Val Pro Pro Ala Leu Pro Gly Val 
            260                 265                 270         


Val Phe Leu Ser Gly Gly Gln Ser Glu Glu Asp Ala Ser Ile Asn Leu 
        275                 280                 285             


Asn Ser Ile Asn Val Leu Gly Pro His Pro Trp Ala Leu Thr Phe Ser 
    290                 295                 300                 


Tyr Gly Arg Ala Leu Gln Ala Ser Val Leu Asn Thr Trp Gln Gly Lys 
305                 310                 315                 320 


Lys Glu Asn Val Ala Lys Ala Arg Ala Val Leu Leu Gln Arg Ala Glu 
                325                 330                 335     


Ala Asn Ser Leu Ala Thr Tyr Gly Lys Tyr Lys Gly Gly Ala Gly Gly 
            340                 345                 350         


Ser Thr Ala Gly Ala Leu Tyr Glu Lys Lys Tyr Val Tyr 
        355                 360                 365 


<210>  3
<211>  366
<212>  PRT
<213>  Plasmodium chabaudi

<400>  3

Cys Val Glu Tyr Lys Asn Ala Pro Met Lys Leu Pro Lys Glu Val Ala 
1               5                   10                  15      


His Glu Leu Ala Glu Thr Ala Lys Lys Leu Val Ala Pro Gly Lys Gly 
            20                  25                  30          


Ile Leu Ala Ala Asp Glu Ser Thr Gln Thr Ile Lys Lys Arg Phe Asp 
        35                  40                  45              


Asn Ile Lys Ile Glu Asn Thr Val Glu Asn Arg Ala Asn Tyr Arg Asp 
    50                  55                  60                  


Leu Leu Phe Gly Thr Lys Gly Leu Gly Lys Phe Ile Ser Gly Ala Ile 
65                  70                  75                  80  


Leu Phe Glu Glu Thr Leu Phe Gln Lys Asn Glu Ala Gly Val Pro Leu 
                85                  90                  95      


Val Asn Leu Leu His Asp Glu Asp Ile Ile Pro Gly Ile Lys Val Asp 
            100                 105                 110         


Lys Gly Leu Val Ser Ile Pro Cys Thr Asp Asp Glu Lys Ser Thr Gln 
        115                 120                 125             


Gly Leu Asp Gly Leu Ala Glu Arg Cys Lys Glu Tyr Tyr Lys Ala Gly 
    130                 135                 140                 


Ala Arg Phe Ala Lys Trp Arg Ala Val Leu Val Ile Asp Pro Val Lys 
145                 150                 155                 160 


Gly Lys Pro Thr Asp Leu Ser Ile His Glu Val Ser Trp Gly Leu Ala 
                165                 170                 175     


Arg Tyr Ala Ala Ile Cys Gln Gln Asn Lys Leu Val Pro Ile Val Glu 
            180                 185                 190         


Pro Glu Ile Leu Ala Asp Gly Gly His Thr Ile Glu Val Cys Ala Thr 
        195                 200                 205             


Val Thr Gln Lys Val Leu Ala Ser Val Phe Lys Ala Leu His Asp Asn 
    210                 215                 220                 


Gly Val Leu Leu Glu Gly Ala Leu Leu Lys Pro Asn Met Val Thr Ala 
225                 230                 235                 240 


Gly Tyr Asp Cys Thr Glu Lys Thr Lys Thr Asp Asp Ile Gly Phe Phe 
                245                 250                 255     


Thr Val Arg Thr Leu Arg Arg Thr Val Pro Pro Ala Leu Pro Gly Val 
            260                 265                 270         


Val Phe Leu Ser Gly Gly Gln Ser Glu Glu Asp Ala Ser Val Asn Leu 
        275                 280                 285             


Asn Ser Ile Asn Val Leu Gly Pro His Pro Trp Ala Leu Thr Phe Ser 
    290                 295                 300                 


Tyr Gly Arg Ala Leu Gln Ala Ser Val Leu Ser Thr Trp Gln Gly Lys 
305                 310                 315                 320 


Lys Glu Asn Val Ala Lys Ala Arg Glu Val Leu Leu Gln Arg Ala Glu 
                325                 330                 335     


Ala Asn Ser Leu Ala Thr Tyr Gly Lys Tyr Lys Gly Gly Ala Gly Gly 
            340                 345                 350         


Ser Thr Ala Gly Ala Ser Leu Tyr Glu Lys Lys Tyr Val Tyr 
        355                 360                 365     


<210>  4
<211>  369
<212>  PRT
<213>  Plasmodium falciparum

<400>  4

Met Ala His Cys Thr Glu Tyr Met Asn Ala Pro Lys Lys Leu Pro Ala 
1               5                   10                  15      


Asp Val Ala Glu Glu Leu Ala Thr Thr Ala Gln Lys Leu Val Gln Ala 
            20                  25                  30          


Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr Gln Thr Ile Lys Lys 
        35                  40                  45              


Arg Phe Asp Asn Ile Lys Leu Glu Asn Thr Ile Glu Asn Arg Ala Ser 
    50                  55                  60                  


Tyr Arg Asp Leu Leu Phe Gly Thr Lys Gly Leu Gly Lys Phe Ile Ser 
65                  70                  75                  80  


Gly Ala Ile Leu Phe Glu Glu Thr Leu Phe Gln Lys Asn Glu Ala Gly 
                85                  90                  95      


Val Pro Met Val Asn Leu Leu His Asn Glu Asn Ile Ile Pro Gly Ile 
            100                 105                 110         


Lys Val Asp Lys Gly Leu Val Asn Ile Pro Cys Thr Asp Glu Glu Lys 
        115                 120                 125             


Ser Thr Gln Gly Leu Asp Gly Leu Ala Glu Arg Cys Lys Glu Tyr Tyr 
    130                 135                 140                 


Lys Ala Gly Ala Arg Phe Ala Lys Trp Arg Thr Val Leu Val Ile Asp 
145                 150                 155                 160 


Thr Ala Lys Gly Lys Pro Thr Asp Leu Ser Ile His Glu Thr Ala Trp 
                165                 170                 175     


Gly Leu Ala Arg Tyr Ala Ser Ile Cys Gln Gln Asn Arg Leu Val Pro 
            180                 185                 190         


Ile Val Glu Pro Glu Ile Leu Ala Asp Gly Pro His Ser Ile Glu Val 
        195                 200                 205             


Cys Ala Val Val Thr Gln Lys Val Leu Ser Cys Val Phe Lys Ala Leu 
    210                 215                 220                 


Gln Glu Asn Gly Val Leu Leu Glu Gly Ala Leu Leu Lys Pro Asn Met 
225                 230                 235                 240 


Val Thr Ala Gly Tyr Glu Cys Thr Ala Lys Thr Thr Thr Gln Asp Val 
                245                 250                 255     


Gly Phe Leu Thr Val Arg Thr Leu Arg Arg Thr Val Pro Pro Ala Leu 
            260                 265                 270         


Pro Gly Val Val Phe Leu Ser Gly Gly Gln Ser Glu Glu Glu Ala Ser 
        275                 280                 285             


Val Asn Leu Asn Ser Ile Asn Ala Leu Gly Pro His Pro Trp Ala Leu 
    290                 295                 300                 


Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser Val Leu Asn Thr Trp 
305                 310                 315                 320 


Gln Gly Lys Lys Glu Asn Val Ala Lys Ala Arg Glu Val Leu Leu Gln 
                325                 330                 335     


Arg Ala Glu Ala Asn Ser Leu Ala Thr Tyr Gly Lys Tyr Lys Gly Gly 
            340                 345                 350         


Ala Gly Gly Glu Asn Ala Gly Ala Ser Leu Tyr Glu Lys Lys Tyr Val 
        355                 360                 365             


Tyr 
    


<210>  5
<211>  389
<212>  PRT
<213>  Plasmodium knowlesi

<400>  5

Met Ser Ala Pro Tyr Pro Arg Met Val Ile Pro Phe Ser Cys Gln Asn 
1               5                   10                  15      


Ser Cys Asp Val Tyr Ala Thr Val Ser Glu Tyr Lys Asn Ala Pro Leu 
            20                  25                  30          


Lys Leu Pro Ala Asp Val Ala Glu Glu Ile Ala Thr Thr Ala Lys Lys 
        35                  40                  45              


Leu Val Gln Ala Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr Gln 
    50                  55                  60                  


Thr Ile Lys Lys Arg Phe Asp Asn Ile Asn Val Glu Asn Thr Val Glu 
65                  70                  75                  80  


Asn Arg Ala Ala Tyr Arg Asp Leu Leu Phe Gly Thr Lys Gly Leu Gly 
                85                  90                  95      


Lys Phe Ile Ser Gly Ala Ile Leu Phe Glu Glu Thr Leu Phe Gln Lys 
            100                 105                 110         


Asn Glu Ala Gly Val Pro Leu Val Asn Leu Leu His Asp Glu Gly Ile 
        115                 120                 125             


Ile Pro Gly Ile Lys Val Asp Lys Gly Leu Val Thr Ile Pro Cys Thr 
    130                 135                 140                 


Asp Asp Glu Lys Ser Thr Gln Gly Leu Asp Gly Leu Ala Glu Arg Cys 
145                 150                 155                 160 


Lys Glu Tyr Tyr Lys Ala Gly Ala Arg Phe Ala Lys Trp Arg Ala Val 
                165                 170                 175     


Leu Val Ile Asp Pro Val Lys Gly Lys Pro Thr Asp Leu Ser Ile Gln 
            180                 185                 190         


Glu Thr Ala Trp Gly Leu Ala Arg Tyr Ala Ser Ile Cys Gln Gln Asn 
        195                 200                 205             


Lys Leu Val Pro Ile Val Glu Pro Glu Ile Leu Ala Asp Gly Ser His 
    210                 215                 220                 


Thr Ile Glu Val Cys Ala Thr Val Thr Gln Lys Val Leu Ala Cys Val 
225                 230                 235                 240 


Phe Lys Ala Leu His Asp Gln Gly Ile Leu Leu Glu Gly Ala Leu Leu 
                245                 250                 255     


Lys Pro Asn Met Val Thr Ala Gly Tyr Asp Cys Thr Val Lys Thr Lys 
            260                 265                 270         


Thr Gln Asp Ile Gly Phe Leu Thr Val Arg Thr Leu Ser Arg Thr Val 
        275                 280                 285             


Pro Pro Ala Leu Pro Gly Val Val Phe Leu Ser Gly Gly Gln Ser Glu 
    290                 295                 300                 


Glu Glu Ala Ser Val Asn Leu Asn Ser Met Asn Val Leu Gly Pro His 
305                 310                 315                 320 


Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser Val 
                325                 330                 335     


Leu Asn Thr Trp Lys Gly Lys Lys Glu Asn Val Ala Lys Ala Arg Glu 
            340                 345                 350         


Val Leu Leu Lys Arg Ala Glu Ala Asn Ser Leu Ala Thr Tyr Gly Lys 
        355                 360                 365             


Tyr Lys Gly Gly Ala Gly Gly Ala Asp Ala Gly Ala Ser Leu Tyr Glu 
    370                 375                 380                 


Lys Lys Tyr Val Tyr 
385                 


<210>  6
<211>  351
<212>  PRT
<213>  Plasmodium vinckei

<400>  6

Met Lys Leu Pro Lys Glu Val Ala Gln Glu Leu Ala Asp Thr Ala Lys 
1               5                   10                  15      


Lys Leu Val Ala Pro Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr 
            20                  25                  30          


Gln Thr Ile Lys Lys Arg Phe Asp Asn Ile Lys Ile Asp Asn Thr Val 
        35                  40                  45              


Glu Asn Arg Ala Ser Tyr Arg Asp Leu Leu Phe Gly Thr Lys Gly Leu 
    50                  55                  60                  


Gly Lys Phe Ile Ser Gly Ala Ile Leu Phe Glu Glu Thr Leu Phe Gln 
65                  70                  75                  80  


Lys Asn Glu Ala Gly Val Pro Leu Val Asn Leu Leu His Asp Gln Asn 
                85                  90                  95      


Ile Ile Pro Gly Ile Lys Val Asp Lys Gly Leu Val Ala Ile Pro Cys 
            100                 105                 110         


Thr Asp Asp Glu Lys Ser Thr Gln Gly Leu Asp Gly Leu Ala Glu Arg 
        115                 120                 125             


Cys Lys Glu Tyr Tyr Lys Ala Gly Ala Arg Phe Ala Lys Trp Arg Ala 
    130                 135                 140                 


Val Leu Val Ile Asp Pro Ala Lys Gly Lys Pro Thr Asp Leu Ser Ile 
145                 150                 155                 160 


Gln Glu Val Ser Trp Gly Leu Ala Arg Tyr Ala Ala Ile Cys Gln Gln 
                165                 170                 175     


Asn Lys Leu Val Pro Ile Val Glu Pro Glu Ile Leu Ala Asp Gly Ala 
            180                 185                 190         


His Thr Ile Glu Val Cys Ala Ala Val Thr Gln Lys Val Leu Ala Ser 
        195                 200                 205             


Val Phe Lys Ala Leu His Asp Asn Gly Val Leu Leu Glu Gly Ala Leu 
    210                 215                 220                 


Leu Lys Pro Asn Met Val Thr Ala Gly Tyr Asp Cys Pro Glu Lys Thr 
225                 230                 235                 240 


Lys Thr Glu Asp Ile Gly Phe Phe Thr Val Arg Thr Leu Ser Arg Thr 
                245                 250                 255     


Val Pro Pro Ala Leu Pro Gly Val Val Phe Leu Ser Gly Gly Gln Ser 
            260                 265                 270         


Glu Glu Asp Ala Ser Val Asn Leu Asn Ser Met Asn Val Leu Gly Pro 
        275                 280                 285             


His Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser 
    290                 295                 300                 


Val Leu Ser Thr Trp Gln Gly Lys Lys Glu Asn Ala Ala Lys Ala Gln 
305                 310                 315                 320 


Glu Val Leu Leu Gln Arg Ala Glu Ala Asn Ser Leu Ala Thr Tyr Gly 
                325                 330                 335     


Lys Tyr Lys Gly Gly Ala Gly Gly Ser Thr Ala Gly Ala Ser Leu 
            340                 345                 350     


<210>  7
<211>  369
<212>  PRT
<213>  Plasmodium vivax

<400>  7

Met Ala Thr Gly Ser Glu Tyr Lys Asn Ala Pro Leu Lys Leu Pro Ala 
1               5                   10                  15      


Glu Val Ala Glu Glu Ile Ala Thr Thr Ala Lys Lys Leu Val Glu Ala 
            20                  25                  30          


Gly Lys Gly Ile Leu Ala Ala Asp Glu Ser Thr Gln Thr Ile Lys Lys 
        35                  40                  45              


Arg Phe Asp Asn Ile Asn Val Glu Asn Thr Ile Glu Asn Arg Ala Ser 
    50                  55                  60                  


Tyr Arg Asp Leu Leu Phe Gly Thr Lys Gly Leu Gly Lys Phe Ile Ser 
65                  70                  75                  80  


Gly Ala Ile Leu Phe Glu Glu Thr Leu Phe Gln Lys Asn Glu Ala Gly 
                85                  90                  95      


Val Pro Leu Val Asn Leu Leu His Asp Glu Gly Ile Ile Pro Gly Ile 
            100                 105                 110         


Lys Val Asp Lys Gly Leu Val Thr Ile Pro Cys Thr Asp Asp Glu Lys 
        115                 120                 125             


Ser Thr Gln Gly Leu Asp Gly Leu Ala Glu Arg Cys Lys Glu Tyr Tyr 
    130                 135                 140                 


Lys Ala Gly Ala Arg Phe Ala Lys Trp Arg Ala Val Leu Val Ile Asp 
145                 150                 155                 160 


Pro Val Lys Gly Lys Pro Thr Asp Leu Ser Ile Gln Glu Thr Ala Trp 
                165                 170                 175     


Gly Leu Ala Arg Tyr Ala Ser Ile Cys Gln Gln Asn Lys Leu Val Pro 
            180                 185                 190         


Ile Val Glu Pro Glu Ile Leu Ala Asp Gly Ser His Thr Ile Glu Val 
        195                 200                 205             


Cys Ala Thr Val Thr Gln Lys Val Leu Ala Ser Val Phe Lys Ala Leu 
    210                 215                 220                 


His Asp Gln Gly Val Leu Leu Glu Gly Ala Leu Leu Lys Pro Asn Met 
225                 230                 235                 240 


Val Thr Ala Gly Tyr Asp Cys Ala Val Lys Thr Asn Thr Gln Asp Ile 
                245                 250                 255     


Gly Phe Leu Thr Val Arg Thr Leu Ser Arg Thr Val Pro Pro Ser Leu 
            260                 265                 270         


Pro Gly Val Val Phe Leu Ser Gly Gly Gln Ser Glu Glu Glu Ala Ser 
        275                 280                 285             


Val Asn Leu Asn Ser Ile Asn Ala Leu Gly Pro His Pro Trp Ala Leu 
    290                 295                 300                 


Thr Phe Ser Tyr Gly Arg Ala Leu Gln Ala Ser Val Leu Asn Thr Trp 
305                 310                 315                 320 


Lys Gly Lys Lys Glu Asn Val Glu Lys Ala Arg Glu Val Leu Leu Lys 
                325                 330                 335     


Arg Ala Glu Ala Asn Ser Leu Ala Thr Tyr Gly Lys Tyr Lys Gly Gly 
            340                 345                 350         


Ala Gly Gly Ala Asp Ala Gly Ala Ser Leu Tyr Glu Lys Lys Tyr Val 
        355                 360                 365             


Tyr 
    


<210>  8
<211>  409
<212>  PRT
<213>  Plasmodium yoelii

<400>  8

Met Tyr Arg Thr Cys Ser Leu Asn Glu Ser Lys Cys Asp Asp Lys Ile 
1               5                   10                  15      


Tyr Ile Asp Leu Tyr Phe Ala Asn Leu Tyr Ile Tyr Asn Arg Lys Phe 
            20                  25                  30          


Gln Arg Leu Leu Lys Cys Ile Leu Thr Val Gly Cys Val Glu Tyr Lys 
        35                  40                  45              


Asn Ala Pro Met Lys Leu Pro Lys Glu Val Ala Gln Glu Leu Ala Glu 
    50                  55                  60                  


Thr Ala Lys Lys Leu Val Ala Ala Gly Lys Gly Ile Leu Ala Ala Asp 
65                  70                  75                  80  


Glu Ser Thr Gln Thr Ile Lys Lys Arg Phe Asp Asn Ile Lys Ile Glu 
                85                  90                  95      


Asn Thr Val Glu Asn Arg Ala Ser Tyr Arg Asp Leu Leu Phe Gly Thr 
            100                 105                 110         


Lys Gly Leu Gly Lys Phe Ile Ser Gly Ala Ile Leu Phe Glu Glu Thr 
        115                 120                 125             


Leu Phe Gln Lys Asn Glu Ala Gly Val Pro Leu Val Asn Leu Leu His 
    130                 135                 140                 


Asp Glu Gly Ile Ile Pro Gly Ile Lys Val Asp Lys Gly Leu Val Ser 
145                 150                 155                 160 


Ile Pro Cys Thr Asp Asp Glu Lys Ser Thr Gln Gly Leu Asp Gly Leu 
                165                 170                 175     


Ala Glu Arg Cys Lys Glu Tyr Tyr Lys Ala Gly Ala Arg Phe Ala Lys 
            180                 185                 190         


Trp Arg Ala Val Leu Val Ile Asp Pro Ala Lys Gly Lys Pro Thr Asp 
        195                 200                 205             


Leu Ser Ile Gln Glu Val Ser Trp Gly Leu Ala Arg Tyr Ala Ser Ile 
    210                 215                 220                 


Cys Gln Gln Asn Lys Leu Val Pro Ile Val Glu Pro Glu Ile Leu Ala 
225                 230                 235                 240 


Asp Gly Ala His Thr Ile Glu Val Cys Ala Thr Val Thr Gln Lys Val 
                245                 250                 255     


Leu Ala Ser Val Phe Lys Ala Leu His Asp Asn Gly Val Leu Leu Glu 
            260                 265                 270         


Gly Ala Leu Leu Lys Pro Asn Met Val Thr Ala Gly Tyr Asp Cys Thr 
        275                 280                 285             


Glu Lys Thr Lys Thr Asp Asp Ile Gly Phe Phe Thr Val Arg Thr Leu 
    290                 295                 300                 


Arg Arg Thr Val Pro Pro Ala Leu Pro Gly Val Val Phe Leu Ser Gly 
305                 310                 315                 320 


Gly Gln Ser Glu Glu Asp Ala Ser Ile Asn Leu Asn Ser Ile Asn Val 
                325                 330                 335     


Leu Gly Pro His Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg Ala Leu 
            340                 345                 350         


Gln Ala Ser Val Leu Asn Thr Trp Gln Gly Lys Lys Glu Asn Val Ala 
        355                 360                 365             


Lys Ala Arg Glu Val Leu Leu Gln Arg Ala Glu Ala Asn Ser Leu Ala 
    370                 375                 380                 


Thr Tyr Gly Lys Tyr Lys Gly Gly Ala Gly Gly Ser Thr Ala Gly Ala 
385                 390                 395                 400 


Ser Leu Tyr Glu Lys Lys Tyr Val Tyr 
                405                 


<210>  9
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  9

Phe Gln Gln Met Trp Ile Thr Lys Glu Glu Tyr Asp Glu Ser Gly 
1               5                   10                  15  


<210>  10
<211>  58
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  10
gatctttcaa caaatgtgga tcacaaaaga ggaatacgat gaatcaggat aagagctc         58


<210>  11
<211>  57
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  11
attgagctct tatcctgatt catcgtattc ctcttttgtg attgccattt gttgaaa          57


<210>  12
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  12

Phe Gln Gln Met Trp Ile Thr Lys Glu Glu Ala Asp Glu Ser Gly 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  13

Phe Gln Gln Met Ala Ile Thr Lys Glu Glu Tyr Asp Glu Ser Gly 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  14

Phe Gln Gln Met Ala Ile Thr Lys Glu Glu Ala Asp Glu Ser Gly 
1               5                   10                  15  


<210>  15
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  15

Ala Ala Ala Trp Ile Thr Lys Glu Glu Tyr Asp Glu 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  16

Ala Ala Ala Trp Ile Thr Lys Gln Gln Tyr Asp Glu 
1               5                   10          


<210>  17
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  17

Trp Ile Thr Lys Glu Glu Tyr Asn Gln 
1               5                   


<210>  18
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
atcgatggat ccggaggtaa ctactatgta tgaaggt                                37


<210>  19
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  19
gctactcgag gcggccgctt atctgtggac aatacttggt cctga                       45


<210>  20
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
atcgatctcg aggcatggga gaagaagatg ttcaagct                               38


<210>  21
<211>  38
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
tcgatcgcgg ccgcttagaa gcattttctg tggacaat                               38


<210>  22
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  22

Trp Ile Thr Lys Glu Glu Tyr Asp Glu 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  23

Glu Asp Trp Tyr Ile Lys Thr Glu Glu 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum derived actin peptide

<400>  24

Asn Ile Thr Lys Gln Gln Asn Asp Glu 
1               5                   


<210>  25
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum TRAP peptide

<400>  25

Glu Thr Leu Gly Glu Glu Asp Lys Asp Leu Asp Glu Pro Glu Gln Phe 
1               5                   10                  15      


Arg Leu Pro Glu Glu Asn Glu Trp Asn 
            20                  25  


<210>  26
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum TRAP peptide

<400>  26

Glu Glu Asn Glu Trp Asn 
1               5       


<210>  27
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium berghei TRAP peptide

<400>  27

Val Met Ala Asp Asp Glu Lys Gly Ile Val Glu Asp Glu Gly Phe Lys 
1               5                   10                  15      


Leu Pro Glu Asp Asn Asp Trp Asn 
            20                  


<210>  28
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium berghei TRAP peptide

<400>  28

Glu Asp Asn Asp Trp Asn 
1               5       


<210>  29
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum TRAP peptide

<400>  29

Pro Glu Gln Phe Arg Leu Pro Glu Glu Asn Glu Trp Asn 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium vivax TRAP peptide

<400>  30

Ala Asp Gln Phe Lys Leu Pro Glu Asp Asn Asp Trp Asn 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum MTRAP peptide

<400>  31

Lys Asp Asn Lys Ala Met Asp Glu Glu Glu Phe Trp Ala 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium vivax MTRAP peptide

<400>  32

Glu Asn Ser Lys Ser Met Tyr Glu Asp Glu Phe Trp Ala 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum CTRP peptide

<400>  33

Asp Phe Glu Val Val Asp Ala Asp Asp Pro Met Trp Asn 
1               5                   10              


<210>  34
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium vivax CTRP peptide

<400>  34

Asp Phe Glu Val Ile Asp Ala Asn Asp Pro Met Trp Asn 
1               5                   10              


<210>  35
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium falciparum TLP peptide

<400>  35

Glu Gln Asn Ile Glu Ile Met Asn Asp Thr Gln Trp Lys 
1               5                   10              


<210>  36
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Plasmodium vivax TLP peptide

<400>  36

Gln Asn Ile Glu Val Lys Pro Asp Glu Thr Ser Trp Gln 
1               5                   10              


<210>  37
<211>  559
<212>  PRT
<213>  Plasmodium falciparum

<400>  37

Met Asn His Leu Gly Asn Val Lys Tyr Leu Val Ile Val Phe Leu Ile 
1               5                   10                  15      


Phe Phe Asp Leu Phe Leu Val Asn Gly Arg Asp Val Gln Asn Asn Ile 
            20                  25                  30          


Val Asp Glu Ile Lys Tyr Ser Glu Glu Val Cys Asn Asp Gln Val Asp 
        35                  40                  45              


Leu Tyr Leu Leu Met Asp Cys Ser Gly Ser Ile Arg Arg His Asn Trp 
    50                  55                  60                  


Val Asn His Ala Val Pro Leu Ala Met Lys Leu Ile Gln Gln Leu Asn 
65                  70                  75                  80  


Leu Asn Asp Asn Ala Ile His Leu Tyr Val Asn Val Phe Ser Asn Asn 
                85                  90                  95      


Ala Lys Glu Ile Ile Arg Leu His Ser Asp Ala Ser Lys Asn Lys Glu 
            100                 105                 110         


Lys Ala Leu Ile Ile Ile Arg Ser Leu Leu Ser Thr Asn Leu Pro Tyr 
        115                 120                 125             


Gly Arg Thr Asn Leu Thr Asp Ala Leu Leu Gln Val Arg Lys His Leu 
    130                 135                 140                 


Asn Asp Arg Ile Asn Arg Glu Asn Ala Asn Gln Leu Val Val Ile Leu 
145                 150                 155                 160 


Thr Asp Gly Ile Pro Asp Ser Ile Gln Asp Ser Leu Lys Glu Ser Arg 
                165                 170                 175     


Lys Leu Ser Asp Arg Gly Val Lys Ile Ala Val Phe Gly Ile Gly Gln 
            180                 185                 190         


Gly Ile Asn Val Ala Phe Asn Arg Phe Leu Val Gly Cys His Pro Ser 
        195                 200                 205             


Asp Gly Lys Cys Asn Leu Tyr Ala Asp Ser Ala Trp Glu Asn Val Lys 
    210                 215                 220                 


Asn Val Ile Gly Pro Phe Met Lys Ala Val Cys Val Glu Val Glu Lys 
225                 230                 235                 240 


Thr Ala Ser Cys Gly Val Trp Asp Glu Trp Ser Pro Cys Ser Val Thr 
                245                 250                 255     


Cys Gly Lys Gly Thr Arg Ser Arg Lys Arg Glu Ile Leu His Glu Gly 
            260                 265                 270         


Cys Thr Ser Glu Ile Gln Glu Gln Cys Glu Glu Glu Arg Cys Pro Pro 
        275                 280                 285             


Lys Trp Glu Pro Leu Asp Val Pro Asp Glu Pro Glu Asp Asp Gln Pro 
    290                 295                 300                 


Arg Pro Arg Gly Asp Asn Ser Ser Val Gln Lys Pro Glu Glu Asn Ile 
305                 310                 315                 320 


Ile Asp Asn Asn Pro Gln Glu Pro Ser Pro Asn Pro Glu Glu Gly Lys 
                325                 330                 335     


Asp Glu Asn Pro Asn Gly Phe Asp Leu Asp Glu Asn Pro Glu Asn Pro 
            340                 345                 350         


Pro Asn Pro Asp Ile Pro Glu Gln Lys Pro Asn Ile Pro Glu Asp Ser 
        355                 360                 365             


Glu Lys Glu Val Pro Ser Asp Val Pro Lys Asn Pro Glu Asp Asp Arg 
    370                 375                 380                 


Glu Glu Asn Phe Asp Ile Pro Lys Lys Pro Glu Asn Lys His Asp Asn 
385                 390                 395                 400 


Gln Asn Asn Leu Pro Asn Asp Lys Ser Asp Arg Asn Ile Pro Tyr Ser 
                405                 410                 415     


Pro Leu Pro Pro Lys Val Leu Asp Asn Glu Arg Lys Gln Ser Asp Pro 
            420                 425                 430         


Gln Ser Gln Asp Asn Asn Gly Asn Arg His Val Pro Asn Ser Glu Asp 
        435                 440                 445             


Arg Glu Thr Arg Pro His Gly Arg Asn Asn Glu Asn Arg Ser Tyr Asn 
    450                 455                 460                 


Arg Lys Tyr Asn Asp Thr Pro Lys His Pro Glu Arg Glu Glu His Glu 
465                 470                 475                 480 


Lys Pro Asp Asn Asn Lys Lys Lys Gly Glu Ser Asp Asn Lys Tyr Lys 
                485                 490                 495     


Ile Ala Gly Gly Ile Ala Gly Gly Leu Ala Leu Leu Ala Cys Ala Gly 
            500                 505                 510         


Leu Ala Tyr Lys Phe Val Val Pro Gly Ala Ala Thr Pro Tyr Ala Gly 
        515                 520                 525             


Glu Pro Ala Pro Phe Asp Glu Thr Leu Gly Glu Glu Asp Lys Asp Leu 
    530                 535                 540                 


Asp Glu Pro Glu Gln Phe Arg Leu Pro Glu Glu Asn Glu Trp Asn 
545                 550                 555                 


<210>  38
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  TRAP consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  X is D, E, or N

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(15)
<223>  X is any amino acid

<400>  38

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa Xaa 
1               5                   10                  15  


