
                                SEQUENCE LISTING

<110> Smith, Peter G
      Blakemore, Stephen J.
      Li, Bin
      Mulligan, George J.
      Schu, Matthew C.
      Millennium Pharmaceuticals, Inc.

<120> BIOMARKERS OF RESPONSE TO NAE INHIBITORS
  

<130> MPI11-009P1RNWO2M

<150> US 61/552,686       
<151> 2011-10-28  

<160> 26

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 6046
<212> DNA
<213> Homo Sapiens

<400> 1
tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc 60
cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg 120
ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt 180
gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc 240
ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg 300
ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag 360
gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg 420
gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct 480
ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga 540
tggagttcaa ttgcgagatg aagtggaaag ggaaggacct ctttgatttg gtgtgccgga 600
ctctggggct ccgagaaacc tggttctttg gactgcagta cacaatcaag gacacagtgg 660
cctggctcaa aatggacaag aaggtactgg atcatgatgt ttcaaaggaa gaaccagtca 720
cctttcactt cttggccaaa ttttatcctg agaatgctga agaggagctg gttcaggaga 780
tcacacaaca tttattcttc ttacaggtaa agaagcagat tttagatgaa aagatctact 840
gccctcctga ggcttctgtg ctcctggctt cttacgccgt ccaggccaag tatggtgact 900
acgaccccag tgttcacaag cggggatttt tggcccaaga ggaattgctt ccaaaaaggg 960
taataaatct gtatcagatg actccggaaa tgtgggagga gagaattact gcttggtacg 1020
cagagcaccg aggccgagcc agggatgaag ctgaaatgga atatctgaag atagctcagg 1080
acctggagat gtacggtgtg aactactttg caatccggaa taaaaagggc acagagctgc 1140
tgcttggagt ggatgccctg gggcttcaca tttatgaccc tgagaacaga ctgaccccca 1200
agatctcctt cccgtggaat gaaatccgaa acatctcgta cagtgacaag gagtttacta 1260
ttaaaccact ggataagaaa attgatgtct tcaagtttaa ctcctcaaag cttcgtgtta 1320
ataagctgat tctccagcta tgtatcggga accatgatct atttatgagg agaaggaaag 1380
ccgattcttt ggaagttcag cagatgaaag cccaggccag ggaggagaag gctagaaagc 1440
agatggagcg gcagcgcctc gctcgagaga agcagatgag ggaggaggct gaacgcacga 1500
gggatgagtt ggagaggagg ctgctgcaga tgaaagaaga agcaacaatg gccaacgaag 1560
cactgatgcg gtctgaggag acagctgacc tgttggctga aaaggcccag atcaccgagg 1620
aggaggcaaa acttctggcc cagaaggccg cagaggctga gcaggaaatg cagcgcatca 1680
aggccacagc gattcgcacg gaggaggaga agcgcctgat ggagcagaag gtgctggaag 1740
ccgaggtgct ggcactgaag atggctgagg agtcagagag gagggccaaa gaggcagatc 1800
agctgaagca ggacctgcag gaagcacgcg aggcggagcg aagagccaag cagaagctcc 1860
tggagattgc caccaagccc acgtacccgc ccatgaaccc aattccagca ccgttgcctc 1920
ctgacatacc aagcttcaac ctcattggtg acagcctgtc tttcgacttc aaagatactg 1980
acatgaagcg gctttccatg gagatagaga aagaaaaagt ggaatacatg gaaaagagca 2040
agcatctgca ggagcagctc aatgaactca agacagaaat cgaggccttg aaactgaaag 2100
agagggagac agctctggat attctgcaca atgagaactc cgacaggggt ggcagcagca 2160
agcacaatac cattaaaaag ctcaccttgc agagcgccaa gtcccgagtg gccttctttg 2220
aagagctcta gcaggtgacc cagccacccc aggacctgcc acttctcctg ctaccgggac 2280
cgcgggatgg accagatatc aagagagcca tccataggga gctggctggg ggtttccgtg 2340
ggagctccag aactttcccc agctgagtga agagcccagc ccctcttatg tgcaattgcc 2400
ttgaactacg accctgtaga gatttctctc atggcgttct agttctctga cctgagtctt 2460
tgttttaaga agtatttgtc ttcctttgtc taatgtggga ttcctgactc ccttcgtcca 2520
aggcaccggt gtgtgtgtgt cttgcactcc agagctgacc tccaccgccc agcctgggaa 2580
gtcattgtag ggagtgagac actgaagccc tgagaagcca gtgccatcat ccccaccccg 2640
cccagggttc cggaacattc attcccccac cggtgaggac ctggcatgca gcgaagcagc 2700
ccagcccggc ggatcccagg ccagcacgcc tgccggcttc tcatcgtcag ggagcccgcc 2760
cagagctcgt gacgagcaag tgctgggtcc ccgccaggca ccccgaggcg gcgctctggc 2820
tggcagctgg tggggaatag gcagggcagc tgtggctggg gagagacttt aggcagaagc 2880
tgtgatgcag gctgactgcc agccgagggg ctgggtagtg ccgtgcggga gctgatggta 2940
cagggcactc gctgtccccc tccggccacc ctagaccagg gtccgagagg caggcaggag 3000
ccactcatgt cttccccatt gcccgacgcc catagacgct ccttcctgtg tggggctggg 3060
gtactccctg gtcgtactgc agtcagcacc cgtaacccgg ctatgaccag ggatctgtaa 3120
gccctgtggc tccacaggtg ctgcttctca ctggcccaga ctctgagctc caccggccca 3180
gtctgcacgg cccatctgct tcaccttccc tcccagccac gtgccagtgg ccacagccca 3240
cttcccaacc cactgttgta cccaggcctc actttgctgt tgcccttgtc cctcttcggg 3300
ccctgaattt tctgttccct gggggccagc cagggccctt tgtgcccctc ccagcacagg 3360
cctgatgcag gtgtccactc acaggtggcg ctcacctagg ctgtcacagg acccacctcc 3420
atgccaggca acagagggcc acagaaccac ccccacggct cactccttgg tctggggcca 3480
ccttcttgcc ctttcttttt tttttttttt ttttttttcc gagatggagt ctctctctgt 3540
cacccaggtg ggagtgtggt ggcacaatct cggctcactg caacctccac ctcctgagtt 3600
caagcaattc tcctgcctca gcctcccaag tagctgggac tacaggcatg caccaccaca 3660
cttggccaat gttctgtatt tttaataggg acggggtttt gccatgttag ctaggctggt 3720
ctcaaactca cacctgggat tacaggcatg agccactgca cccagcccct tcttgccctt 3780
tcttttctcc atggctgatg ctgctgtggc cagccagggc ccttgagatc cttccagttt 3840
ggctgttatg caaagcaggt gatttgtctt aatcagataa aagatagagg ctatgggggc 3900
ctcaagattt ttggagagca gaggtggtct ctggcaattc catctggttt tgagaaactt 3960
agcagctcac agagcacaga gatcctgcct tcttcctact atcaggctga cctaatgggg 4020
ttgggctgct cggcaactgc ttgggtcacc ttgccccaag gaaaccagcc ctgggtgcca 4080
cccagccact tagggtctac agggtgggac tccagaccta gagcgtaagt atggatgttg 4140
tggccctgtg tcttcctagt gtgacccagc caggagcgga agcttcaggc gtttgtaaag 4200
tgaggtctgg ctctgcctcc tccgtttttt ttttttttct gtttctgttt ctgttttttt 4260
tttgagatgg agtctcgctc tgtcgcccag gctggagtgc agtgtcacga tctcagctca 4320
ctgcaacctc cgcctcccag gtacaagaga ttctcctgcc tcagcctccc gagtagctgg 4380
gactacaggc gtgtgccacc atgcctggct aatttttgta tttttagtag agatggggtt 4440
tcgccatgtt agccagactg gtctcgaact cctgacctca ggtgatcctc ccaccccggc 4500
ttcccaaagt tctgggatta taggcgtgag ccaccatgcc cggtctcttc tcagtcttga 4560
agcccatccc tggatttcca ccaggagtta ctttcctcct gacctgtaaa tttgttcttt 4620
aacaatggct gcaggtggga gcatatggtg gtttataaaa acgctgtcgg gctttgtttc 4680
cttctttagc tgccgtgtct acttctgaag tctgggaagt gccaagccac gcggcctcaa 4740
gggagctggc tggtgtttga gctgtggcag aagcacctgg ggctccaggg agcaggctgg 4800
gaactgcagg accttgctca gccaggagca cttccccctc cttgaggcag gaatactgag 4860
gtgcctcccc acagatggag aaggtggaga ggaggatggg cctcaggagc atctcaagcc 4920
ccagtagcag gagaaagaaa gaaagagatg cctggttttc acagactggt tcctgtggct 4980
gggatgactg catccttttt tttttttttt tgagacggag tttttgcctt tgtcgcccag 5040
gctggagtgc aatggcgtga tctcggctca ccgcaacctc cgcctcccgg attcaagcaa 5100
ttctcctgcc tcagcctccc gagtagctgg gattacaggc acgcacctcc acgtccggct 5160
aattttgtat ttttagtgga gacggggttt ctccatgtcg gtcaggctgg tctcgaactc 5220
ccgacctcag gtgatctgcc cacctcggcc tcccaaagtg ctgggattac aggcatgagc 5280
caccgcgctt ggccagactg cgtccttttt aagcgaacat tttagggcct gggagtttgt 5340
caagtaagga agtctcaagc ccaaagagca gcgtcctgac catggtggtt tcattacgag 5400
cccttctgct ggctctcagg cagaagcccc acagcaccgg gaccattcat gaggtcactg 5460
cccagctcat gatgtccgtg aggctgtcct tttggccagt agccgtgtgc agctgtgtgg 5520
cacagatggc ttcgttcatc ctgatcaagg ccccacctca gccacagcag tccccccaac 5580
ctgtgttgtc caccctatta ttcatgtacc tgccaggccc tgctagatag caccccgtgg 5640
cattacataa cacttcatga gtggctgtgt cttgtaattt tggggacagg tttctctctt 5700
tccctctctt ttttttgtca aaagcccaga gactgacaac cagctgcagt gtctaagtgt 5760
tcctcactga cagggtgggg cctcaccacc cctggaggga gcagcgttgg cagggagaca 5820
gcctggccca gtgaccctgg gcccaagcca gcccctccag ggctttcagg gaagcgccat 5880
ccattttcaa agatgtcaaa cgtcacttct tcctgtaggg cccgagtcct gcctcctatc 5940
agggccagat catagaaggc tattttctat tctggggaac gattataact taaatgattg 6000
ttttaataaa aattctaagc tggaaaataa aaaaaaaaaa aaaaaa                6046



<210> 2
<211> 1788
<212> DNA
<213> homo sapiens

<400> 2
atggccgggg ccatcgcttc ccgcatgagc ttcagctctc tcaagaggaa gcaacccaag 60
acgttcaccg tgaggatcgt caccatggac gccgagatgg agttcaattg cgagatgaag 120
tggaaaggga aggacctctt tgatttggtg tgccggactc tggggctccg agaaacctgg 180
ttctttggac tgcagtacac aatcaaggac acagtggcct ggctcaaaat ggacaagaag 240
gtactggatc atgatgtttc aaaggaagaa ccagtcacct ttcacttctt ggccaaattt 300
tatcctgaga atgctgaaga ggagctggtt caggagatca cacaacattt attcttctta 360
caggtaaaga agcagatttt agatgaaaag atctactgcc ctcctgaggc ttctgtgctc 420
ctggcttctt acgccgtcca ggccaagtat ggtgactacg accccagtgt tcacaagcgg 480
ggatttttgg cccaagagga attgcttcca aaaagggtaa taaatctgta tcagatgact 540
ccggaaatgt gggaggagag aattactgct tggtacgcag agcaccgagg ccgagccagg 600
gatgaagctg aaatggaata tctgaagata gctcaggacc tggagatgta cggtgtgaac 660
tactttgcaa tccggaataa aaagggcaca gagctgctgc ttggagtgga tgccctgggg 720
cttcacattt atgaccctga gaacagactg acccccaaga tctccttccc gtggaatgaa 780
atccgaaaca tctcgtacag tgacaaggag tttactatta aaccactgga taagaaaatt 840
gatgtcttca agtttaactc ctcaaagctt cgtgttaata agctgattct ccagctatgt 900
atcgggaacc atgatctatt tatgaggaga aggaaagccg attctttgga agttcagcag 960
atgaaagccc aggccaggga ggagaaggct agaaagcaga tggagcggca gcgcctcgct 1020
cgagagaagc agatgaggga ggaggctgaa cgcacgaggg atgagttgga gaggaggctg 1080
ctgcagatga aagaagaagc aacaatggcc aacgaagcac tgatgcggtc tgaggagaca 1140
gctgacctgt tggctgaaaa ggcccagatc accgaggagg aggcaaaact tctggcccag 1200
aaggccgcag aggctgagca ggaaatgcag cgcatcaagg ccacagcgat tcgcacggag 1260
gaggagaagc gcctgatgga gcagaaggtg ctggaagccg aggtgctggc actgaagatg 1320
gctgaggagt cagagaggag ggccaaagag gcagatcagc tgaagcagga cctgcaggaa 1380
gcacgcgagg cggagcgaag agccaagcag aagctcctgg agattgccac caagcccacg 1440
tacccgccca tgaacccaat tccagcaccg ttgcctcctg acataccaag cttcaacctc 1500
attggtgaca gcctgtcttt cgacttcaaa gatactgaca tgaagcggct ttccatggag 1560
atagagaaag aaaaagtgga atacatggaa aagagcaagc atctgcagga gcagctcaat 1620
gaactcaaga cagaaatcga ggccttgaaa ctgaaagaga gggagacagc tctggatatt 1680
ctgcacaatg agaactccga caggggtggc agcagcaagc acaataccat taaaaagctc 1740
accttgcaga gcgccaagtc ccgagtggcc ttctttgaag agctctag              1788

<210> 3
<211> 595
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg
 1               5                  10                  15      
Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu
            20                  25                  30          
Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp
        35                  40                  45              
Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu
    50                  55                  60                  
Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys
65                  70                  75                  80  
Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe
                85                  90                  95      
Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu
            100                 105                 110         
Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp
        115                 120                 125             
Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr
    130                 135                 140                 
Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg
145                 150                 155                 160 
Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu
                165                 170                 175     
Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr
            180                 185                 190         
Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu
        195                 200                 205             
Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile
    210                 215                 220                 
Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly
225                 230                 235                 240 
Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe
                245                 250                 255     
Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr
            260                 265                 270         
Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser
        275                 280                 285             
Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His
    290                 295                 300                 
Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln
305                 310                 315                 320 
Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg
                325                 330                 335     
Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr
            340                 345                 350         
Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr
        355                 360                 365             
Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu
    370                 375                 380                 
Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln
385                 390                 395                 400 
Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala
                405                 410                 415     
Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu
            420                 425                 430         
Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala
        435                 440                 445             
Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala
    450                 455                 460                 
Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr
465                 470                 475                 480 
Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro
                485                 490                 495     
Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr
            500                 505                 510         
Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr
        515                 520                 525             
Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr
    530                 535                 540                 
Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile
545                 550                 555                 560 
Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr
                565                 570                 575     
Ile Lys Lys Leu Thr Leu Gln Ser Ala Lys Ser Arg Val Ala Phe Phe
            580                 585                 590         
Glu Glu Leu
        595 


<210> 4
<211> 8789
<212> DNA
<213> Homo sapiens

<400> 4
atgctcagtg gcttctcgac aagttggcag caacaacacg gccctggtcg tcgtcgccgc 60
tgcggtaacg gagcggtttg ggtggcggag cctgcgttcg cgccttcccg ctctcctcgg 120
gaggcccttc ctgctctccc ctaggctccg cggccgccca gggggtggga gcgggtgagg 180
ggagccaggc gcccagcgag agaggccccc cgccgcaggg cggcccggga gctcgaggcg 240
gtccggcccg cgcgggcagc ggcgcggcgc tgaggagggg cggcctggcc gggacgcctc 300
ggggcggggg ccgaggagct ctccgggccg ccggggaaag ctacgggccc ggtgcgtccg 360
cggaccagca gcgcgggaga gcggactccc ctcgccaccg cccgagccca ggttatcctg 420
aatacatgtc taacaatttt ccttgcaacg ttagctgttg tttttcactg tttccaaagg 480
atcaaaattg cttcagaaat tggagacata tttgatttaa aaggaaaaac ttgaacaaat 540
ggacaatatg tctattacga atacaccaac aagtaatgat gcctgtctga gcattgtgca 600
tagtttgatg tgccatagac aaggtggaga gagtgaaaca tttgcaaaaa gagcaattga 660
aagtttggta aagaagctga aggagaaaaa agatgaattg gattctttaa taacagctat 720
aactacaaat ggagctcatc ctagtaaatg tgttaccata cagagaacat tggatgggag 780
gcttcaggtg gctggtcgga aaggatttcc tcatgtgatc tatgcccgtc tctggaggtg 840
gcctgatctt cacaaaaatg aactaaaaca tgttaaatat tgtcagtatg cgtttgactt 900
aaaatgtgat agtgtctgtg tgaatccata tcactacgaa cgagttgtat cacctggaat 960
tgatctctca ggattaacac tgcagagtaa tgctccatca agtatgatgg tgaaggatga 1020
atatgtgcat gactttgagg gacagccatc gttgtccact gaaggacatt caattcaaac 1080
catccagcat ccaccaagta atcgtgcatc gacagagaca tacagcaccc cagctctgtt 1140
agccccatct gagtctaatg ctaccagcac tgccaacttt cccaacattc ctgtggcttc 1200
cacaagtcag cctgccagta tactgggggg cagccatagt gaaggactgt tgcagatagc 1260
atcagggcct cagccaggac agcagcagaa tggatttact ggtcagccag ctacttacca 1320
tcataacagc actaccacct ggactggaag taggactgca ccatacacac ctaatttgcc 1380
tcaccaccaa aacggccatc ttcagcacca cccgcctatg ccgccccatc ccggacatta 1440
ctggcctgtt cacaatgagc ttgcattcca gcctcccatt tccaatcatc ctgctcctga 1500
gtattggtgt tccattgctt actttgaaat ggatgttcag gtaggagaga catttaaggt 1560
tccttcaagc tgccctattg ttactgttga tggatacgtg gacccttctg gaggagatcg 1620
cttttgtttg ggtcaactct ccaatgtcca caggacagaa gccattgaga gagcaaggtt 1680
gcacataggc aaaggtgtgc agttggaatg taaaggtgaa ggtgatgttt gggtcaggtg 1740
ccttagtgac cacgcggtct ttgtacagag ttactactta gacagagaag ctgggcgtgc 1800
acctggagat gctgttcata agatctaccc aagtgcatat ataaaggtct ttgatttgcg 1860
tcagtgtcat cgacagatgc agcagcaggc ggctactgca caagctgcag cagctgccca 1920
ggcagcagcc gtggcaggaa acatccctgg cccaggatca gtaggtggaa tagctccagc 1980
tatcagtctg tcagctgctg ctggaattgg tgttgatgac cttcgtcgct tatgcatact 2040
caggatgagt tttgtgaaag gctggggacc ggattaccca agacagagca tcaaagaaac 2100
accttgctgg attgaaattc acttacaccg ggccctccag ctcctagacg aagtacttca 2160
taccatgccg attgcagacc cacaaccttt agactgaggt cttttaccgt tggggccctt 2220
aaccttatca ggatggtgga ctacaaaata caatcctgtt tataatctga agatatattt 2280
cacttttgtt ctgctttatc ttttcataaa gggttgaaaa tgtgtttgct gccttgctcc 2340
tagcagacag aaactggatt aaaacaattt tttttttcct cttcagaact tgtcaggcat 2400
ggctcagagc ttgaagatta ggagaaacac attcttatta attcttcacc tgttatgtat 2460
gaaggaatca ttccagtgct agaaaattta gccctttaaa acgtcttaga gccttttatc 2520
tgcagaacat cgatatgtat atcattctac agaataatcc agtattgctg attttaaagg 2580
cagagaagtt ctcaaagtta attcacctat gttattttgt gtacaagttg ttattgttga 2640
acatacttca aaaataatgt gccatgtggg tgagttaatt ttaccaagag taactttact 2700
ctgtgtttaa aaagtaagtt aataatgtat tgtaatcttt catccaaaat attttttgca 2760
agttatatta gtgaagatgg tttcaattca gattgtcttg caacttcagt tttatttttg 2820
ccaaggcaaa aaactcttaa tctgtgtgta tattgagaat cccttaaaat taccagacaa 2880
aaaaatttaa aattacgttt gttattccta gtggatgact gttgatgaag tatacttttc 2940
ccctgttaaa cagtagttgt attcttctgt atttctaggc acaaggttgg ttgctaagaa 3000
gcctataaga ggaatttctt ttccttcatt catagggaaa ggttttgtat tttttaaaac 3060
actaaaagca gcgtcactct acctaatgtc tcactgttct gcaaaggtgg caatgcttaa 3120
actaaataat gaataaactg aatattttgg aaactgctaa attctatgtt aaatactgtg 3180
cagaataatg gaaacattac agttcataat aggtagtttg gatatttttg tacttgattt 3240
gatgtgactt tttttggtat aatgtttaaa tcatgtatgt tatgatattg tttaaaattc 3300
agtttttgta tcttggggca agactgcaaa cttttttata tcttttggtt attctaagcc 3360
ctttgccatc aatgatcata tcaattggca gtgactttgt atagagaatt taagtagaaa 3420
agttgcagat gtattgactg taccacagac acaatatgta tgctttttac ctagctggta 3480
gcataaataa aactgaatct caacatacaa agttgaattc taggtttgat ttttaagatt 3540
ttttttttct tttgcacttt tgagtccaat ctcagtgatg aggtaccttc tactaaatga 3600
caggcaacag ccagttctat tgggcagctt tgtttttttc cctcacactc taccgggact 3660
tccccatgga cattgtgtat catgtgtaga gttggttttt ttttttttta atttttattt 3720
tactatagca gaaatagacc tgattatcta caagatgata aatagattgt ctacaggata 3780
aatagtatga aataaaatca aggattatct ttcagatgtg tttacttttg cctggagaac 3840
ttttagctat agaaacactt gtgtgatgat agtcctcctt atatcacctg gaatgaacac 3900
agcttctact gccttgctca gaaggtcttt taaatagacc atcctagaaa ccactgagtt 3960
tgcttatttc tgtgatttaa acatagatct tgatccaagc tacatgactt ttgtctttaa 4020
ataacttatc taccacctca tttgtactct tgattactta caaattcttt cagtaaacac 4080
ctaattttct tctgtaaaag tttggtgatt taagttttat tggcagtttt ataaaaagac 4140
atcttctcta gaaattgcta actttaggtc cattttactg tgaatgagga ataggagtga 4200
gttttagaat aacagatttt taaaaatcca gatgatttga ttaaaacctt aatcatacat 4260
tgacataatt cattgcttct tttttttgag atatggagtc ttgctgtgtt gcccaggcag 4320
gagtgcagtg gtatgatctc agctcactgc aacctctgcc tcccgggttc aactgattct 4380
cctgcctcag cctccctggt agctaggatt acaggtgccc gccaccatgc ctggctaact 4440
tttgtagttt tagtagagac ggggttttgc ctgttggcca ggctggtctt gaactcctga 4500
cctcaagtga tccatccacc ttggcctccc aaagtgctgg gattacgggc gtgagccact 4560
gtccctggcc tcattgttcc cttttctact ttaaggaaag ttttcatgtt taatcatctg 4620
gggaaagtat gtgaaaaata tttgttaaga agtatctctt tggagccaag ccacctgtct 4680
tggtttcttt ctactaagag ccataaagta tagaaatact tctagttgtt aagtgcttat 4740
atttgtacct agatttagtc acacgctttt gagaaaacat ctagtatgtt atgatcagct 4800
attcctgaga gcttggttgt taatctatat ttctatttct tagtggtagt catctttgat 4860
gaataagact aaagattctc acaggtttaa aattttatgt ctactttaag ggtaaaatta 4920
tgaggttatg gttctgggtg ggttttctct agctaattca tatctcaaag agtctcaaaa 4980
tgttgaattt cagtgcaagc tgaatgagag atgagccatg tacacccacc gtaagacctc 5040
attccatgtt tgtccagtgc ctttcagtgc attatcaaag ggaatccttc atggtgttgc 5100
ctttattttc cggggagtag atcgtgggat atagtctatc tcatttttaa tagtttaccg 5160
cccctggtat acaaagataa tgacaataaa tcactgccat ataaccttgc tttttccaga 5220
aacatggctg ttttgtattg ctgtaaccac taaataggtt gcctatacca ttcctcctgt 5280
gaacagtgca gatttacagg ttgcatggtc tggcttaagg agagccatac ttgagacatg 5340
tgagtaaact gaactcatat tagctgtgct gcatttcaga cttaaaatcc atttttgtgg 5400
ggcagggtgt ggtgtgtaaa ggggggtgtt tgtaatacaa gttgaaggca aaataaaatg 5460
tcctgtctcc cagatgatat acatcttatt atttttaaag tttattgcta attgtaggaa 5520
ggtgagttgc aggtatcttt gactatggtc atctggggaa ggaaaatttt acattttact 5580
attaatgctc cttaagtgtc tatggaggtt aaagaataaa atggtaaatg tttctgtgcc 5640
tggtttgatg gtaactggtt aatagttact caccatttta tgcagagtca cattagttca 5700
caccctttct gagagccttt tgggagaagc agttttattc tctgagtgga acagagttct 5760
ttttgttgat aatttctagt ttgctccctt cgttattgcc aactttactg gcattttatt 5820
taatgatagc agattgggaa aatggcaaat ttaggttacg gaggtaaatg agtatatgaa 5880
agcaattacc tctaaagcca gttaacaatt attttgtagg tggggtacac tcagcttaaa 5940
gtaatgcatt tttttttccc gtaaaggcag aatccatctt gttgcagata gctatctaaa 6000
taatctcata tcctcttttg caaagactac agagaatagg ctatgacaat cttgttcaag 6060
cctttccatt tttttccctg ataactaagt aatttctttg aacataccaa gaagtatgta 6120
aaaagtccat ggccttattc atccacaaag tggcatccta ggcccagcct tatccctagc 6180
agttgtccca gtgctgctag gttgcttatc ttgtttatct ggaatcactg tggagtgaaa 6240
ttttccacat catccagaat tgccttattt aagaagtaaa acgttttaat ttttagcctt 6300
tttttggtgg agttatttaa tatgtatatc agaggatata ctagatggta acatttcttt 6360
ctgtgcttgg ctatctttgt ggacttcagg ggcttctaaa acagacagga ctgtgttgcc 6420
tttactaaat ggtctgagac agctatggtt ttgaattttt agtttttttt ttttaaccca 6480
cttcccctcc tggtctcttc cctctctgat aattaccatt catatgtgag tgttagtgtg 6540
cctcctttta gcattttctt cttctctttc tgattcttca tttctgactg cctaggcaag 6600
gaaaccagat aaccaaactt actagaacgt tctttaaaac acaagtacaa actctgggac 6660
aggacccaag acactttcct gtgaagtgct gaaaaagacc tcattgtatt ggcatttgat 6720
atcagtttga tgtagcttag agtgcttcct gattcttgct gagtttcagg tagttgagat 6780
agagagaagt gagtcatatt catattttcc cccttagaat aatattttga aaggtttcat 6840
tgcttccact tgaatgctgc tcttacaaaa actggggtta caagggttac taaattagca 6900
tcagtagcca gaggcaatac cgttgtctgg aggacaccag caaacaacac acaacaaagc 6960
aaaacaaacc ttgggaaact aaggccattt gttttgtttt ggtgtcccct ttgaagccct 7020
gccttctggc cttactcctg tacagatatt tttgacctat aggtgccttt atgagaattg 7080
agggtctgac atcctgcccc aaggagtagc taaagtaatt gctagtgttt tcagggattt 7140
taacatcaga ctggaatgaa tgaatgaaac tttttgtcct ttttttttct gttttttttt 7200
ttctaatgta gtaaggacta aggaaaacct ttggtgaaga caatcatttc tctctgttga 7260
tgtggatact tttcacaccg tttatttaaa tgctttctca ataggtccag agccagtgtt 7320
cttgttcaac ctgaaagtaa tggctctggg ttgggccaga cagttgcact ctctagtttg 7380
ccctctgcca caaatttgat gtgtgacctt tgggcaagtc atttatcttc tctgggcctt 7440
agttgcctca tctgtaaaat gagggagttg gagtagatta attattccag ctctgaaatt 7500
ctaagtgacc ttggctacct tgcagcagtt ttggatttct tccttatctt tgttctgctg 7560
tttgaggggg ctttttactt atttccatgt tattcaaagg agactaggct tgatatttta 7620
ttactgttct tttatggaca aaaggttaca tagtatgccc ttaagactta attttaacca 7680
aaggcctagc accaccttag gggctgcaat aaacacttaa cgcgcgtgcg cacgcgcgcg 7740
cgcacacaca cacacacaca cacacacaca cacaggtcag agtttaaggc tttcgagtca 7800
tgacattcta gcttttgaat tgcgtgcaca cacacacgca cgcacacact ctggtcagag 7860
tttattaagg ctttcgagtc atgacattat agcttttgag ttggtgtgtg tgacaccacc 7920
ctcctaagtg gtgtgtgctt gtaatttttt ttttcagtga aaatggattg aaaacctgtt 7980
gttaatgctt agtgatatta tgctcaaaac aaggaaattc ccttgaaccg tgtcaattaa 8040
actggtttat atgactcaag aaaacaatac cagtagatga ttattaactt tattcttggc 8100
tctttttagg tccattttga ttaagtgact tttggctgga tcattcagag ctctcttcta 8160
gcctaccctt ggatgagtac aattaatgaa attcatattt tcaaggacct gggagccttc 8220
cttggggctg ggttgagggt ggggggttgg ggagtcctgg tagaggccag ctttgtggta 8280
gctggagagg aagggatgaa accagctgct gttgcaaagg ctgcttgtca ttgatagaag 8340
gactcacggg cttggattga ttaagactaa acatggagtt ggcaaacttt cttcaagtat 8400
tgagttctgt tcaatgcatt ggacatgtga tttaagggaa aagtgtgaat gcttatagat 8460
gatgaaaacc tggtgggctg cagagcccag tttagaagaa gtgagttggg ggttggggac 8520
agatttggtg gtggtatttc ccaactgttt cctcccctaa attcagagga atgcagctat 8580
gccagaagcc agagaagagc cactcgtagc ttctgctttg gggacaactg gtcagttgaa 8640
agtcccagga gttcctttgt ggctttctgt atacttttgc ctggttaaag tctgtggcta 8700
aaaaatagtc gaacctttct tgagaactct gtaacaaagt atgtttttga ttaaaagaga 8760
aagccaacta aaaaaaaaaa aaaaaaaaa                                   8789



<210> 5
<211> 1659
<212> DNA
<213> Homo sapiens

<400> 5
atggacaata tgtctattac gaatacacca acaagtaatg atgcctgtct gagcattgtg 60
catagtttga tgtgccatag acaaggtgga gagagtgaaa catttgcaaa aagagcaatt 120
gaaagtttgg taaagaagct gaaggagaaa aaagatgaat tggattcttt aataacagct 180
ataactacaa atggagctca tcctagtaaa tgtgttacca tacagagaac attggatggg 240
aggcttcagg tggctggtcg gaaaggattt cctcatgtga tctatgcccg tctctggagg 300
tggcctgatc ttcacaaaaa tgaactaaaa catgttaaat attgtcagta tgcgtttgac 360
ttaaaatgtg atagtgtctg tgtgaatcca tatcactacg aacgagttgt atcacctgga 420
attgatctct caggattaac actgcagagt aatgctccat caagtatgat ggtgaaggat 480
gaatatgtgc atgactttga gggacagcca tcgttgtcca ctgaaggaca ttcaattcaa 540
accatccagc atccaccaag taatcgtgca tcgacagaga catacagcac cccagctctg 600
ttagccccat ctgagtctaa tgctaccagc actgccaact ttcccaacat tcctgtggct 660
tccacaagtc agcctgccag tatactgggg ggcagccata gtgaaggact gttgcagata 720
gcatcagggc ctcagccagg acagcagcag aatggattta ctggtcagcc agctacttac 780
catcataaca gcactaccac ctggactgga agtaggactg caccatacac acctaatttg 840
cctcaccacc aaaacggcca tcttcagcac cacccgccta tgccgcccca tcccggacat 900
tactggcctg ttcacaatga gcttgcattc cagcctccca tttccaatca tcctgctcct 960
gagtattggt gttccattgc ttactttgaa atggatgttc aggtaggaga gacatttaag 1020
gttccttcaa gctgccctat tgttactgtt gatggatacg tggacccttc tggaggagat 1080
cgcttttgtt tgggtcaact ctccaatgtc cacaggacag aagccattga gagagcaagg 1140
ttgcacatag gcaaaggtgt gcagttggaa tgtaaaggtg aaggtgatgt ttgggtcagg 1200
tgccttagtg accacgcggt ctttgtacag agttactact tagacagaga agctgggcgt 1260
gcacctggag atgctgttca taagatctac ccaagtgcat atataaaggt ctttgatttg 1320
cgtcagtgtc atcgacagat gcagcagcag gcggctactg cacaagctgc agcagctgcc 1380
caggcagcag ccgtggcagg aaacatccct ggcccaggat cagtaggtgg aatagctcca 1440
gctatcagtc tgtcagctgc tgctggaatt ggtgttgatg accttcgtcg cttatgcata 1500
ctcaggatga gttttgtgaa aggctgggga ccggattacc caagacagag catcaaagaa 1560
acaccttgct ggattgaaat tcacttacac cgggccctcc agctcctaga cgaagtactt 1620
cataccatgc cgattgcaga cccacaacct ttagactga                        1659

<210> 6
<211> 552
<212> PRT
<213> Homo sapiens

<400> 6
Met Asp Asn Met Ser Ile Thr Asn Thr Pro Thr Ser Asn Asp Ala Cys
 1               5                  10                  15      
Leu Ser Ile Val His Ser Leu Met Cys His Arg Gln Gly Gly Glu Ser
            20                  25                  30          
Glu Thr Phe Ala Lys Arg Ala Ile Glu Ser Leu Val Lys Lys Leu Lys
        35                  40                  45              
Glu Lys Lys Asp Glu Leu Asp Ser Leu Ile Thr Ala Ile Thr Thr Asn
    50                  55                  60                  
Gly Ala His Pro Ser Lys Cys Val Thr Ile Gln Arg Thr Leu Asp Gly
65                  70                  75                  80  
Arg Leu Gln Val Ala Gly Arg Lys Gly Phe Pro His Val Ile Tyr Ala
                85                  90                  95      
Arg Leu Trp Arg Trp Pro Asp Leu His Lys Asn Glu Leu Lys His Val
            100                 105                 110         
Lys Tyr Cys Gln Tyr Ala Phe Asp Leu Lys Cys Asp Ser Val Cys Val
        115                 120                 125             
Asn Pro Tyr His Tyr Glu Arg Val Val Ser Pro Gly Ile Asp Leu Ser
    130                 135                 140                 
Gly Leu Thr Leu Gln Ser Asn Ala Pro Ser Ser Met Met Val Lys Asp
145                 150                 155                 160 
Glu Tyr Val His Asp Phe Glu Gly Gln Pro Ser Leu Ser Thr Glu Gly
                165                 170                 175     
His Ser Ile Gln Thr Ile Gln His Pro Pro Ser Asn Arg Ala Ser Thr
            180                 185                 190         
Glu Thr Tyr Ser Thr Pro Ala Leu Leu Ala Pro Ser Glu Ser Asn Ala
        195                 200                 205             
Thr Ser Thr Ala Asn Phe Pro Asn Ile Pro Val Ala Ser Thr Ser Gln
    210                 215                 220                 
Pro Ala Ser Ile Leu Gly Gly Ser His Ser Glu Gly Leu Leu Gln Ile
225                 230                 235                 240 
Ala Ser Gly Pro Gln Pro Gly Gln Gln Gln Asn Gly Phe Thr Gly Gln
                245                 250                 255     
Pro Ala Thr Tyr His His Asn Ser Thr Thr Thr Trp Thr Gly Ser Arg
            260                 265                 270         
Thr Ala Pro Tyr Thr Pro Asn Leu Pro His His Gln Asn Gly His Leu
        275                 280                 285             
Gln His His Pro Pro Met Pro Pro His Pro Gly His Tyr Trp Pro Val
    290                 295                 300                 
His Asn Glu Leu Ala Phe Gln Pro Pro Ile Ser Asn His Pro Ala Pro
305                 310                 315                 320 
Glu Tyr Trp Cys Ser Ile Ala Tyr Phe Glu Met Asp Val Gln Val Gly
                325                 330                 335     
Glu Thr Phe Lys Val Pro Ser Ser Cys Pro Ile Val Thr Val Asp Gly
            340                 345                 350         
Tyr Val Asp Pro Ser Gly Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser
        355                 360                 365             
Asn Val His Arg Thr Glu Ala Ile Glu Arg Ala Arg Leu His Ile Gly
    370                 375                 380                 
Lys Gly Val Gln Leu Glu Cys Lys Gly Glu Gly Asp Val Trp Val Arg
385                 390                 395                 400 
Cys Leu Ser Asp His Ala Val Phe Val Gln Ser Tyr Tyr Leu Asp Arg
                405                 410                 415     
Glu Ala Gly Arg Ala Pro Gly Asp Ala Val His Lys Ile Tyr Pro Ser
            420                 425                 430         
Ala Tyr Ile Lys Val Phe Asp Leu Arg Gln Cys His Arg Gln Met Gln
        435                 440                 445             
Gln Gln Ala Ala Thr Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala
    450                 455                 460                 
Val Ala Gly Asn Ile Pro Gly Pro Gly Ser Val Gly Gly Ile Ala Pro
465                 470                 475                 480 
Ala Ile Ser Leu Ser Ala Ala Ala Gly Ile Gly Val Asp Asp Leu Arg
                485                 490                 495     
Arg Leu Cys Ile Leu Arg Met Ser Phe Val Lys Gly Trp Gly Pro Asp
            500                 505                 510         
Tyr Pro Arg Gln Ser Ile Lys Glu Thr Pro Cys Trp Ile Glu Ile His
        515                 520                 525             
Leu His Arg Ala Leu Gln Leu Leu Asp Glu Val Leu His Thr Met Pro
    530                 535                 540                 
Ile Ala Asp Pro Gln Pro Leu Asp
545                 550         


<210> 7
<211> 5778
<212> DNA
<213> Homo sapiens

<400> 7
gtgacacaat tacaacaact ttgtgctggt gccggggaag tttgtgtctc caacgaatcc 60
cctcagtgct ccccagcccc gcgcgctccg gccgttcccg ccgtccccgc ctgtggctgc 120
cccctgccca accccgcgat gtgaccctac agccgaaagc cgccgctgcc gacccggggg 180
ctccgcagcc cctgccgccg ccgccgccgc cttcaccgcc gccgcgttgg gatttttcgt 240
cgccgccgcc cgcggcggag gaggaggcgg cgataaagtt ggtgtgctgg tcccgcgcgc 300
agattggggg cgtcactgcg ggccccggtc cgaggggggg tgtcggcgtt ggagttgtga 360
attcgctgcg tttccatgaa atcctgcgga gtgtcgctcg ctaccgccgc cgctgccgcc 420
gccgctttcg gtgatgagga aaagaaaatg gcggcgggaa aagcgagcgg cgagagcgag 480
gaggcgtccc ccagcctgac agccgaggag agggaggcgc tcggcggact ggacagccgc 540
ctctttgggt tcgtgagatt tcatgaagat ggcgccagga cgaaggccct actgggcaag 600
gctgttcgct gctatgaatc tctaatctta aaagctgaag gaaaagtgga gtctgatttc 660
ttttgtcaat taggtcactt caacctctta ttggaagatt atccaaaagc attatctgca 720
taccagaggt actacagttt acagtctgac tactggaaga atgctgcctt tttatatggt 780
cttggtttgg tctacttcca ttataatgca tttcagtggg caattaaagc atttcaggag 840
gtgctttatg ttgatcccag cttttgtcga gccaaggaaa ttcatttacg acttgggctt 900
atgttcaaag tgaacacaga ctatgagtct agtttaaagc attttcagtt agctttggtt 960
gactgtaatc cctgcacttt gtccaatgct gaaattcaat ttcacattgc ccacttatat 1020
gaaacccaga ggaaatatca ttctgcaaaa gaagcttatg aacaactttt gcagacagag 1080
aatctttctg cacaagtaaa agcaactgtc ttacaacagt taggttggat gcatcacact 1140
gtagatctcc tgggagataa agccaccaag gaaagctatg ctattcagta tctccaaaag 1200
tccttggaag cagatcctaa ttctggccag tcctggtatt tcctcggaag gtgctattca 1260
agtattggga aagttcagga tgcctttata tcttacaggc agtctattga taaatcagaa 1320
gcaagtgcag atacatggtg ttcaataggt gtgctatatc agcagcaaaa tcagcccatg 1380
gatgctttac aggcctatat ttgtgctgta caattggacc atggccatgc tgcagcctgg 1440
atggacctag gcactctcta tgaatcctgc aaccagcctc aggatgccat taaatgctac 1500
ttaaatgcaa ctagaagcaa aagttgtagt aatacctctg cacttgcagc acgaattaag 1560
tatttacagg ctcagttgtg taaccttcca caaggtagtc tacagaataa aactaaatta 1620
cttcctagta ttgaggaggc gtggagccta ccaattcccg cagagcttac ctccaggcag 1680
ggtgccatga acacagcaca gcagaatact tctgacaatt ggagtggtgg acatgctgtg 1740
tcacatcctc cagtacagca acaagctcat tcatggtgtt tgacaccaca gaaattacag 1800
catttggaac agctccgcgc aaatagaaat aatttaaatc cagcacagaa actgatgctg 1860
gaacagctgg aaagtcagtt tgtcttaatg caacaacacc aaatgagacc aacaggagtt 1920
gcacaggtac gatctactgg aattcctaat gggccaacag ctgactcatc actgcctaca 1980
aactcagtct ctggccagca gccacagctt gctctgacca gagtgcctag cgtctctcag 2040
cctggagtcc gtcctgcctg ccctgggcag cctttggcca atggaccctt ttctgcaggc 2100
catgttccct gtagcacatc aagaacgctg ggaagtacag acactatttt gataggcaat 2160
aatcatataa caggaagtgg aagtaatgga aacgtgcctt acctgcagcg aaacgcactc 2220
actctacctc ataaccgcac aaacctgacc agcagcgcag aggagccgtg gaaaaaccaa 2280
ctatctaact ccactcaggg gcttcacaaa ggtcagagtt cacattcggc aggtcctaat 2340
ggtgaacgac ctctctcttc cactgggcct tcccagcatc tccaggcagc tggctctggt 2400
attcagaatc agaacggaca tcccaccctg cctagcaatt cagtaacaca gggggctgct 2460
ctcaatcacc tctcctctca cactgctacc tcaggtggac aacaaggcat taccttaacc 2520
aaagagagca agccttcagg aaacatattg acggtgcctg aaacaagcag gcacactgga 2580
gagacaccta acagcactgc cagtgtcgag ggacttccta atcatgtcca tcagatgacg 2640
gcagatgctg tttgcagtcc tagccatgga gattctaagt caccaggttt actaagttca 2700
gacaatcctc agctctctgc cttgttgatg ggaaaagcca ataacaatgt gggtactgga 2760
acctgtgaca aagtcaataa catccaccca gctgttcata caaagactga taactctgtt 2820
gcctcttcac catcttcagc catttcaaca gcaacacctt ctccaaaatc cactgagcag 2880
acaaccacaa acagtgttac cagccttaac agccctcaca gtgggctaca cacaattaat 2940
ggagaaggga tggaagaatc tcagagcccc atgaaaacag atctgcttct ggttaaccac 3000
aaacctagtc cacagatcat accatcaatg tctgtgtcca tataccccag ctcagcagaa 3060
gttctgaagg catgcaggaa tctaggtaaa aatggcttat ctaacagtag cattttgttg 3120
gataaatgtc cacctccaag accaccatct tcaccatacc ctcccttgcc aaaggacaag 3180
ttgaatccac ctacacctag tatttacttg gaaaataaac gtgatgcttt ctttcctcca 3240
ttacatcaat tttgtacaaa tccgaacaac cctgttacag taatacgtgg ccttgctgga 3300
gctcttaagt tagacctggg acttttctct actaaaactt tggtggaagc taacaatgaa 3360
catatggtag aagtgaggac acagttgttg cagccagcag atgaaaactg ggatcccact 3420
ggaacaaaga aaatctggca ttgtgaaagt aatagatctc atactacaat tgctaaatat 3480
gcacagtacc aggcctcctc attccaggaa tcattgagag aagaaaatga aaaaagaagt 3540
catcataaag accactcaga tagtgaatct acatcgtcag ataattctgg gaggaggagg 3600
aaaggaccct ttaaaaccat aaagtttggg accaatattg acctatctga tgacaaaaag 3660
tggaagttgc agctacatga gctgactaaa cttcctgctt ttgtgcgtgt cgtatcagca 3720
ggaaatcttc taagccatgt tggtcatacc atattgggca tgaacacagt tcaactatac 3780
atgaaagttc cagggagcag aacaccaggt catcaggaaa ataacaactt ctgttcagtt 3840
aacataaata ttggcccagg tgactgtgaa tggtttgttg ttcctgaagg ttactggggt 3900
gttctgaatg acttctgtga aaaaaataat ttgaatttcc taatgggttc ttggtggccc 3960
aatcttgaag atctttatga agcaaatgtt ccagtgtata ggtttattca gcgacctgga 4020
gatttggtct ggataaatgc aggcactgtt cattgggttc aggctattgg ctggtgcaac 4080
aacattgctt ggaatgttgg tccacttaca gcctgccagt ataaattggc agtggaacgg 4140
tacgaatgga acaaattgca aagtgtgaag tcaatagtac ccatggttca tctttcctgg 4200
aatatggcac gaaatatcaa ggtctcagat ccaaagcttt ttgaaatgat taagtattgt 4260
cttctaagaa ctctgaagca atgtcagaca ttgagggaag ctctcattgc tgcaggaaaa 4320
gagattatat ggcatgggcg gacaaaagaa gaaccagctc attactgtag catttgtgaa 4380
gtggaggttt ttgatctgct ttttgtcact aatgagagta attcacgaaa gacctacata 4440
gtacattgcc aagattgtgc acgaaaaaca agcggaaact tggaaaactt tgtggtgcta 4500
gaacagtaca aaatggagga cctgatgcaa gtctatgacc aatttacatt agctcctcca 4560
ttaccatccg cctcatcttg atattgttcc atggacatta aatgagacct tttctgctat 4620
tcaggaaata acccagttct gcaccactgg tttttgtagc tatctcgtaa ggctgctggc 4680
tgaaaactgt gtctatgcaa ccttccaagt gcggagtgtc aaccaactgg acgggagaga 4740
gtactgctcc tactccagga ctctcacaaa gctgatgagc tgtacttcag aaaaaaataa 4800
taatttccat gttttgtata tatctgacaa aactggcaac atcttacaga ctactgactt 4860
gaagacaacc tcttttatat ttctctattt ctgggctgat gaatttgttt tcatctgtct 4920
tttccccctt cagaattttc cttggaaaaa aaatactagc ctagctggtc atttctttgt 4980
aaggtagtta gcaattttaa gtctttcttt ggtcaacttt tttttaatgt gaaaagttag 5040
gtaagacact tttttactgc ttttatgttt ttctgtcttg ttttgagacc atgatggtta 5100
cacttttggt tcctaaataa aatttaaaaa attaacagcc aagtcacaaa ggtaatggat 5160
tgcacataga ctaaggaata aacttcagat ttgtgatttt tgtttctaat cttgatgtaa 5220
atttacacta tttataaata catatttatt gcttgaaaat atttgtgaat ggaatgctgt 5280
tattttttcc agatttacct gccattgaaa ttttaaggag ttctgtaatt tcaaacacta 5340
ctcctattac attttctatg tgtaaataaa actgcttagc attgtacaga aacttttatt 5400
aaaattgttt aatgtttaaa gagttttcta ttgtttgagt tttaaaaaag actttatgta 5460
cagtgcccag tttttgttca tttttgaaat ctgattatat atattttata tatacttatg 5520
tatgtatata taatatatat agaaatctgg atatatatgt ataaatcttt agaacttaaa 5580
tttttctcgt tttaagtttc acatctatgg tagatttttg aggtgtctac tgtaaagtat 5640
tgcttacaaa aagtatgatt atttttaaag aaatatatat ggtatgtatc ctcaagacct 5700
aaaatgtcag actggtttat tgttaagttg caattactgc aatgacagac caataaacaa 5760
ttgctgccaa aaaaaaaa                                               5778



<210> 8
<211> 4206
<212> DNA
<213> Homo sapiens

<400> 8
atgaaatcct gcggagtgtc gctcgctacc gccgccgctg ccgccgccgc tttcggtgat 60
gaggaaaaga aaatggcggc gggaaaagcg agcggcgaga gcgaggaggc gtcccccagc 120
ctgacagccg aggagaggga ggcgctcggc ggactggaca gccgcctctt tgggttcgtg 180
agatttcatg aagatggcgc caggacgaag gccctactgg gcaaggctgt tcgctgctat 240
gaatctctaa tcttaaaagc tgaaggaaaa gtggagtctg atttcttttg tcaattaggt 300
cacttcaacc tcttattgga agattatcca aaagcattat ctgcatacca gaggtactac 360
agtttacagt ctgactactg gaagaatgct gcctttttat atggtcttgg tttggtctac 420
ttccattata atgcatttca gtgggcaatt aaagcatttc aggaggtgct ttatgttgat 480
cccagctttt gtcgagccaa ggaaattcat ttacgacttg ggcttatgtt caaagtgaac 540
acagactatg agtctagttt aaagcatttt cagttagctt tggttgactg taatccctgc 600
actttgtcca atgctgaaat tcaatttcac attgcccact tatatgaaac ccagaggaaa 660
tatcattctg caaaagaagc ttatgaacaa cttttgcaga cagagaatct ttctgcacaa 720
gtaaaagcaa ctgtcttaca acagttaggt tggatgcatc acactgtaga tctcctggga 780
gataaagcca ccaaggaaag ctatgctatt cagtatctcc aaaagtcctt ggaagcagat 840
cctaattctg gccagtcctg gtatttcctc ggaaggtgct attcaagtat tgggaaagtt 900
caggatgcct ttatatctta caggcagtct attgataaat cagaagcaag tgcagataca 960
tggtgttcaa taggtgtgct atatcagcag caaaatcagc ccatggatgc tttacaggcc 1020
tatatttgtg ctgtacaatt ggaccatggc catgctgcag cctggatgga cctaggcact 1080
ctctatgaat cctgcaacca gcctcaggat gccattaaat gctacttaaa tgcaactaga 1140
agcaaaagtt gtagtaatac ctctgcactt gcagcacgaa ttaagtattt acaggctcag 1200
ttgtgtaacc ttccacaagg tagtctacag aataaaacta aattacttcc tagtattgag 1260
gaggcgtgga gcctaccaat tcccgcagag cttacctcca ggcagggtgc catgaacaca 1320
gcacagcaga atacttctga caattggagt ggtggacatg ctgtgtcaca tcctccagta 1380
cagcaacaag ctcattcatg gtgtttgaca ccacagaaat tacagcattt ggaacagctc 1440
cgcgcaaata gaaataattt aaatccagca cagaaactga tgctggaaca gctggaaagt 1500
cagtttgtct taatgcaaca acaccaaatg agaccaacag gagttgcaca ggtacgatct 1560
actggaattc ctaatgggcc aacagctgac tcatcactgc ctacaaactc agtctctggc 1620
cagcagccac agcttgctct gaccagagtg cctagcgtct ctcagcctgg agtccgtcct 1680
gcctgccctg ggcagccttt ggccaatgga cccttttctg caggccatgt tccctgtagc 1740
acatcaagaa cgctgggaag tacagacact attttgatag gcaataatca tataacagga 1800
agtggaagta atggaaacgt gccttacctg cagcgaaacg cactcactct acctcataac 1860
cgcacaaacc tgaccagcag cgcagaggag ccgtggaaaa accaactatc taactccact 1920
caggggcttc acaaaggtca gagttcacat tcggcaggtc ctaatggtga acgacctctc 1980
tcttccactg ggccttccca gcatctccag gcagctggct ctggtattca gaatcagaac 2040
ggacatccca ccctgcctag caattcagta acacaggggg ctgctctcaa tcacctctcc 2100
tctcacactg ctacctcagg tggacaacaa ggcattacct taaccaaaga gagcaagcct 2160
tcaggaaaca tattgacggt gcctgaaaca agcaggcaca ctggagagac acctaacagc 2220
actgccagtg tcgagggact tcctaatcat gtccatcaga tgacggcaga tgctgtttgc 2280
agtcctagcc atggagattc taagtcacca ggtttactaa gttcagacaa tcctcagctc 2340
tctgccttgt tgatgggaaa agccaataac aatgtgggta ctggaacctg tgacaaagtc 2400
aataacatcc acccagctgt tcatacaaag actgataact ctgttgcctc ttcaccatct 2460
tcagccattt caacagcaac accttctcca aaatccactg agcagacaac cacaaacagt 2520
gttaccagcc ttaacagccc tcacagtggg ctacacacaa ttaatggaga agggatggaa 2580
gaatctcaga gccccatgaa aacagatctg cttctggtta accacaaacc tagtccacag 2640
atcataccat caatgtctgt gtccatatac cccagctcag cagaagttct gaaggcatgc 2700
aggaatctag gtaaaaatgg cttatctaac agtagcattt tgttggataa atgtccacct 2760
ccaagaccac catcttcacc ataccctccc ttgccaaagg acaagttgaa tccacctaca 2820
cctagtattt acttggaaaa taaacgtgat gctttctttc ctccattaca tcaattttgt 2880
acaaatccga acaaccctgt tacagtaata cgtggccttg ctggagctct taagttagac 2940
ctgggacttt tctctactaa aactttggtg gaagctaaca atgaacatat ggtagaagtg 3000
aggacacagt tgttgcagcc agcagatgaa aactgggatc ccactggaac aaagaaaatc 3060
tggcattgtg aaagtaatag atctcatact acaattgcta aatatgcaca gtaccaggcc 3120
tcctcattcc aggaatcatt gagagaagaa aatgaaaaaa gaagtcatca taaagaccac 3180
tcagatagtg aatctacatc gtcagataat tctgggagga ggaggaaagg accctttaaa 3240
accataaagt ttgggaccaa tattgaccta tctgatgaca aaaagtggaa gttgcagcta 3300
catgagctga ctaaacttcc tgcttttgtg cgtgtcgtat cagcaggaaa tcttctaagc 3360
catgttggtc ataccatatt gggcatgaac acagttcaac tatacatgaa agttccaggg 3420
agcagaacac caggtcatca ggaaaataac aacttctgtt cagttaacat aaatattggc 3480
ccaggtgact gtgaatggtt tgttgttcct gaaggttact ggggtgttct gaatgacttc 3540
tgtgaaaaaa ataatttgaa tttcctaatg ggttcttggt ggcccaatct tgaagatctt 3600
tatgaagcaa atgttccagt gtataggttt attcagcgac ctggagattt ggtctggata 3660
aatgcaggca ctgttcattg ggttcaggct attggctggt gcaacaacat tgcttggaat 3720
gttggtccac ttacagcctg ccagtataaa ttggcagtgg aacggtacga atggaacaaa 3780
ttgcaaagtg tgaagtcaat agtacccatg gttcatcttt cctggaatat ggcacgaaat 3840
atcaaggtct cagatccaaa gctttttgaa atgattaagt attgtcttct aagaactctg 3900
aagcaatgtc agacattgag ggaagctctc attgctgcag gaaaagagat tatatggcat 3960
gggcggacaa aagaagaacc agctcattac tgtagcattt gtgaagtgga ggtttttgat 4020
ctgctttttg tcactaatga gagtaattca cgaaagacct acatagtaca ttgccaagat 4080
tgtgcacgaa aaacaagcgg aaacttggaa aactttgtgg tgctagaaca gtacaaaatg 4140
gaggacctga tgcaagtcta tgaccaattt acattagctc ctccattacc atccgcctca 4200
tcttga                                                            4206

<210> 9
<211> 4206
<212> DNA
<213> Homo sapiens

<400> 9
atgaaatcct gcggagtgtc gctcgctacc gccgccgctg ccgccgccgc tttcggtgat 60
gaggaaaaga aaatggcggc gggaaaagcg agcggcgaga gcgaggaggc gtcccccagc 120
ctgacagccg aggagaggga ggcgctcggc ggactggaca gccgcctctt tgggttcgtg 180
agatttcatg aagatggcgc caggacgaag gccctactgg gcaaggctgt tcgctgctat 240
gaatctctaa tcttaaaagc tgaaggaaaa gtggagtctg atttcttttg tcaattaggt 300
cacttcaacc tcttattgga agattatcca aaagcattat ctgcatacca gaggtactac 360
agtttacagt ctgactactg gaagaatgct gcctttttat atggtcttgg tttggtctac 420
ttccattata atgcatttca gtgggcaatt aaagcatttc aggaggtgct ttatgttgat 480
cccagctttt gtcgagccaa ggaaattcat ttacgagttg ggcttatgtt caaagtgaac 540
acagactatg agtctagttt aaagcatttt cagttagctt tggttgactg taatccctgc 600
actttgtcca atgctgaaat tcaatttcac attgcccact tatatgaaac ccagaggaaa 660
tatcattctg caaaagaagc ttatgaacaa cttttgcaga cagagaatct ttctgcacaa 720
gtaaaagcaa ctgtcttaca acagttaggt tggatgcatc acactgtaga tctcctggga 780
gataaagcca ccaaggaaag ctatgctatt cagtatctcc aaaagtcctt ggaagcagat 840
cctaattctg gccagtcctg gtatttcctc ggaaggtgct attcaagtat tgggaaagtt 900
caggatgcct ttatatctta caggcagtct attgataaat cagaagcaag tgcagataca 960
tggtgttcaa taggtgtgct atatcagcag caaaatcagc ccatggatgc tttacaggcc 1020
tatatttgtg ctgtacaatt ggaccatggc catgctgcag cctggatgga cctaggcact 1080
ctctatgaat cctgcaacca gcctcaggat gccattaaat gctacttaaa tgcaactaga 1140
agcaaaagtt gtagtaatac ctctgcactt gcagcacgaa ttaagtattt acaggctcag 1200
ttgtgtaacc ttccacaagg tagtctacag aataaaacta aattacttcc tagtattgag 1260
gaggcgtgga gcctaccaat tcccgcagag cttacctcca ggcagggtgc catgaacaca 1320
gcacagcaga atacttctga caattggagt ggtggacatg ctgtgtcaca tcctccagta 1380
cagcaacaag ctcattcatg gtgtttgaca ccacagaaat tacagcattt ggaacagctc 1440
cgcgcaaata gaaataattt aaatccagca cagaaactga tgctggaaca gctggaaagt 1500
cagtttgtct taatgcaaca acaccaaatg agaccaacag gagttgcaca ggtacgatct 1560
actggaattc ctaatgggcc aacagctgac tcatcactgc ctacaaactc agtctctggc 1620
cagcagccac agcttgctct gaccagagtg cctagcgtct ctcagcctgg agtccgtcct 1680
gcctgccctg ggcagccttt ggccaatgga cccttttctg caggccatgt tccctgtagc 1740
acatcaagaa cgcggggaag tacagacact attttgatag gcaataatca tataacagga 1800
aatggaagta atggaaacgt gccttacctg cagcgaaacg cactcactct acctcataac 1860
cgcacaaacc tgaccagcag cgcaaaggag ccgtggaaaa accaactatc taactccact 1920
caggggcttc acaaaggtca gagttcacat tcggcaggtc ctaatggtga acgacctctc 1980
tcttccactg ggccttccca gcatctccag gcagctggct ctggtattca gaatcagaac 2040
ggacatccca ccctgcctag caattcagta acacaggggg ctgctctcaa tcacctctcc 2100
tctcacactg ctacctcagg tggacaacaa ggcattacct taaccaaaga gagcaagcct 2160
tcaggaaaca tattgacggt gcctgaaaca agcaggcaca ctggagagac acctaacagc 2220
actgccagtg tcgagggact tcctaatcat gtccatcaga tgacggcaga tgctgtttgc 2280
agtcctagcc atggagattc taagtcacca ggtttactaa gttcagacaa tcctcagctc 2340
tctgccttgt tgatgggaaa agccaataac aatgtgggta ctggaacctg tgacaaagtc 2400
aataacatcc acccagctgt tcatacaaag actgataact ctgttgcctc ttcaccatct 2460
tcagccattt caacagcaac accttctcca aaatccactg agcagacaac cacaaacagt 2520
gttaccagcc ttaacagccc tcacagtggg ctacacacaa ttaatggaga agggatggaa 2580
gaatctcaga gccccatgaa aacagatctg cttctggtta accacaaacc tagtccacag 2640
atcataccat caatgtctgt gtccatatac cccagctcag cagaagttct gaaggcatgc 2700
aggaatctag gtaaaaatgg cttatctaac agtagcattt tgttggataa atgtccacct 2760
ccaagaccac catcttcacc ataccctccc ttgccaaagg acaagttgaa tccacctaca 2820
cctagtattt acttggaaaa taaacgtgat gctttctttc ctccattaca tcaattttgt 2880
acaaatccga acaaccctgt tacagtaata cgtggccttg ctggagctct taagttagac 2940
ctgggacttt tctctactaa aactttggtg gaagctaaca atgaacatat ggtagaagtg 3000
aggacacagt tgttgcagcc agcagatgaa aactgggatc ccactggaac aaagaaaatc 3060
tggcattgtg aaagtaatag atctcatact acaattgcta aatatgcaca gtaccaggcc 3120
tcctcattcc aggaatcatt gagagaagaa aatgaaaaaa gaagtcatca taaagaccac 3180
tcagatagtg aatctacatc gtcagataat tctgggagga ggaggaaagg accctttaaa 3240
accataaagt ttgggaccaa tattgaccta tctgatgaca aaaagtggaa gttgcagcta 3300
catgagctga ctaaacttcc tgcttttgtg cgtgtcgtat cagcaggaaa tcttctaagc 3360
catgttggtc ataccatatt gggcatgaac acagttcaac tatacatgaa agttccaggg 3420
agcagaacac caggtcatca ggaaaataac aacttctgtt cagttaacat aaatattggc 3480
ccaggtgact gtgaatggtt tgttgttcct gaaggttact ggggtgtttt gaatgacttc 3540
tgtgaaaaaa ataatttgaa tttcctaatg ggttcttggt ggcccaatct tgaagatctt 3600
tatgaagcaa atgttccagt gtataggttt attcagcgac ctggagattt ggtctggata 3660
aatgcaggca ctgttcattg ggttcaggct attggctggt gcaacaacat tgcttggaat 3720
gttggtccac ttacagcctg ccagtataaa ttggcagtgg aacggtacga atggaacaaa 3780
ttgcaaagtg tgaagtcaat agtacccatg gttcatcttt cctggaatat ggcacgaaat 3840
atcaaggtct cagatccaaa gctttttgaa atgattaagt attgtcttct aagaactctg 3900
aagcaatgtc agacattgag ggaagctctc attgctgcag gaaaagagat tatatggcat 3960
gggcggacaa aagaagaacc agctcattac tgtagcattt gtgaagtgga ggtttttgat 4020
ctgctttttg tcactaatga gagtaattca cgaaagacct acatagtaca ttgccaagat 4080
tgtgcacgaa aaacaagcgg aaacttggaa aactttgtgg tgctagaaca gtacaaaatg 4140
gaggacctga tgcaagtcta tgaccaattt acattagctc ctccattacc atccgcctca 4200
tcttga                                                            4206

<210> 10
<211> 1401
<212> PRT
<213> Homo sapiens

<400> 10
Met Lys Ser Cys Gly Val Ser Leu Ala Thr Ala Ala Ala Ala Ala Ala
 1               5                  10                  15      
Ala Phe Gly Asp Glu Glu Lys Lys Met Ala Ala Gly Lys Ala Ser Gly
            20                  25                  30          
Glu Ser Glu Glu Ala Ser Pro Ser Leu Thr Ala Glu Glu Arg Glu Ala
        35                  40                  45              
Leu Gly Gly Leu Asp Ser Arg Leu Phe Gly Phe Val Arg Phe His Glu
    50                  55                  60                  
Asp Gly Ala Arg Thr Lys Ala Leu Leu Gly Lys Ala Val Arg Cys Tyr
65                  70                  75                  80  
Glu Ser Leu Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe
                85                  90                  95      
Cys Gln Leu Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Pro Lys Ala
            100                 105                 110         
Leu Ser Ala Tyr Gln Arg Tyr Tyr Ser Leu Gln Ser Asp Tyr Trp Lys
        115                 120                 125             
Asn Ala Ala Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe His Tyr Asn
    130                 135                 140                 
Ala Phe Gln Trp Ala Ile Lys Ala Phe Gln Glu Val Leu Tyr Val Asp
145                 150                 155                 160 
Pro Ser Phe Cys Arg Ala Lys Glu Ile His Leu Arg Leu Gly Leu Met
                165                 170                 175     
Phe Lys Val Asn Thr Asp Tyr Glu Ser Ser Leu Lys His Phe Gln Leu
            180                 185                 190         
Ala Leu Val Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln
        195                 200                 205             
Phe His Ile Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala
    210                 215                 220                 
Lys Glu Ala Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Ser Ala Gln
225                 230                 235                 240 
Val Lys Ala Thr Val Leu Gln Gln Leu Gly Trp Met His His Thr Val
                245                 250                 255     
Asp Leu Leu Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr
            260                 265                 270         
Leu Gln Lys Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr
        275                 280                 285             
Phe Leu Gly Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe
    290                 295                 300                 
Ile Ser Tyr Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr
305                 310                 315                 320 
Trp Cys Ser Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp
                325                 330                 335     
Ala Leu Gln Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala
            340                 345                 350         
Ala Ala Trp Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro
        355                 360                 365             
Gln Asp Ala Ile Lys Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys
    370                 375                 380                 
Ser Asn Thr Ser Ala Leu Ala Ala Arg Ile Lys Tyr Leu Gln Ala Gln
385                 390                 395                 400 
Leu Cys Asn Leu Pro Gln Gly Ser Leu Gln Asn Lys Thr Lys Leu Leu
                405                 410                 415     
Pro Ser Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr
            420                 425                 430         
Ser Arg Gln Gly Ala Met Asn Thr Ala Gln Gln Asn Thr Ser Asp Asn
        435                 440                 445             
Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala
    450                 455                 460                 
His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu
465                 470                 475                 480 
Arg Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu
                485                 490                 495     
Gln Leu Glu Ser Gln Phe Val Leu Met Gln Gln His Gln Met Arg Pro
            500                 505                 510         
Thr Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr
        515                 520                 525             
Ala Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln
    530                 535                 540                 
Leu Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro
545                 550                 555                 560 
Ala Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His
                565                 570                 575     
Val Pro Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu
            580                 585                 590         
Ile Gly Asn Asn His Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro
        595                 600                 605             
Tyr Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu
    610                 615                 620                 
Thr Ser Ser Ala Glu Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr
625                 630                 635                 640 
Gln Gly Leu His Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly
                645                 650                 655     
Glu Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala
            660                 665                 670         
Gly Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn
        675                 680                 685             
Ser Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala
    690                 695                 700                 
Thr Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro
705                 710                 715                 720 
Ser Gly Asn Ile Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu
                725                 730                 735     
Thr Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His
            740                 745                 750         
Gln Met Thr Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys
        755                 760                 765             
Ser Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu
    770                 775                 780                 
Met Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val
785                 790                 795                 800 
Asn Asn Ile His Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala
                805                 810                 815     
Ser Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser
            820                 825                 830         
Thr Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His
        835                 840                 845             
Ser Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser
    850                 855                 860                 
Pro Met Lys Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln
865                 870                 875                 880 
Ile Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val
                885                 890                 895     
Leu Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser
            900                 905                 910         
Ile Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr
        915                 920                 925             
Pro Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr
    930                 935                 940                 
Leu Glu Asn Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys
945                 950                 955                 960 
Thr Asn Pro Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala
                965                 970                 975     
Leu Lys Leu Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala
            980                 985                 990         
Asn Asn Glu His Met Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala
        995                 1000                1005            
Asp Glu Asn Trp Asp Pro Thr Gly Thr Lys Lys Ile Trp His Cys Glu
    1010                1015                1020                
Ser Asn Arg Ser His Thr Thr Ile Ala Lys Tyr Ala Gln Tyr Gln Ala
1025                1030                1035               1040 
Ser Ser Phe Gln Glu Ser Leu Arg Glu Glu Asn Glu Lys Arg Ser His
                1045                1050                1055    
His Lys Asp His Ser Asp Ser Glu Ser Thr Ser Ser Asp Asn Ser Gly
            1060                1065                1070        
Arg Arg Arg Lys Gly Pro Phe Lys Thr Ile Lys Phe Gly Thr Asn Ile
        1075                1080                1085            
Asp Leu Ser Asp Asp Lys Lys Trp Lys Leu Gln Leu His Glu Leu Thr
    1090                1095                1100                
Lys Leu Pro Ala Phe Val Arg Val Val Ser Ala Gly Asn Leu Leu Ser
1105                1110                1115               1120 
His Val Gly His Thr Ile Leu Gly Met Asn Thr Val Gln Leu Tyr Met
                1125                1130                1135    
Lys Val Pro Gly Ser Arg Thr Pro Gly His Gln Glu Asn Asn Asn Phe
            1140                1145                1150        
Cys Ser Val Asn Ile Asn Ile Gly Pro Gly Asp Cys Glu Trp Phe Val
        1155                1160                1165            
Val Pro Glu Gly Tyr Trp Gly Val Leu Asn Asp Phe Cys Glu Lys Asn
    1170                1175                1180                
Asn Leu Asn Phe Leu Met Gly Ser Trp Trp Pro Asn Leu Glu Asp Leu
1185                1190                1195               1200 
Tyr Glu Ala Asn Val Pro Val Tyr Arg Phe Ile Gln Arg Pro Gly Asp
                1205                1210                1215    
Leu Val Trp Ile Asn Ala Gly Thr Val His Trp Val Gln Ala Ile Gly
            1220                1225                1230        
Trp Cys Asn Asn Ile Ala Trp Asn Val Gly Pro Leu Thr Ala Cys Gln
        1235                1240                1245            
Tyr Lys Leu Ala Val Glu Arg Tyr Glu Trp Asn Lys Leu Gln Ser Val
    1250                1255                1260                
Lys Ser Ile Val Pro Met Val His Leu Ser Trp Asn Met Ala Arg Asn
1265                1270                1275               1280 
Ile Lys Val Ser Asp Pro Lys Leu Phe Glu Met Ile Lys Tyr Cys Leu
                1285                1290                1295    
Leu Arg Thr Leu Lys Gln Cys Gln Thr Leu Arg Glu Ala Leu Ile Ala
            1300                1305                1310        
Ala Gly Lys Glu Ile Ile Trp His Gly Arg Thr Lys Glu Glu Pro Ala
        1315                1320                1325            
His Tyr Cys Ser Ile Cys Glu Val Glu Val Phe Asp Leu Leu Phe Val
    1330                1335                1340                
Thr Asn Glu Ser Asn Ser Arg Lys Thr Tyr Ile Val His Cys Gln Asp
1345                1350                1355               1360 
Cys Ala Arg Lys Thr Ser Gly Asn Leu Glu Asn Phe Val Val Leu Glu
                1365                1370                1375    
Gln Tyr Lys Met Glu Asp Leu Met Gln Val Tyr Asp Gln Phe Thr Leu
            1380                1385                1390        
Ala Pro Pro Leu Pro Ser Ala Ser Ser
        1395                1400    


<210> 11
<211> 1401
<212> PRT
<213> Homo sapiens

<400> 11
Met Lys Ser Cys Gly Val Ser Leu Ala Thr Ala Ala Ala Ala Ala Ala
 1               5                  10                  15      
Ala Phe Gly Asp Glu Glu Lys Lys Met Ala Ala Gly Lys Ala Ser Gly
            20                  25                  30          
Glu Ser Glu Glu Ala Ser Pro Ser Leu Thr Ala Glu Glu Arg Glu Ala
        35                  40                  45              
Leu Gly Gly Leu Asp Ser Arg Leu Phe Gly Phe Val Arg Phe His Glu
    50                  55                  60                  
Asp Gly Ala Arg Thr Lys Ala Leu Leu Gly Lys Ala Val Arg Cys Tyr
65                  70                  75                  80  
Glu Ser Leu Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe
                85                  90                  95      
Cys Gln Leu Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Pro Lys Ala
            100                 105                 110         
Leu Ser Ala Tyr Gln Arg Tyr Tyr Ser Leu Gln Ser Asp Tyr Trp Lys
        115                 120                 125             
Asn Ala Ala Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe His Tyr Asn
    130                 135                 140                 
Ala Phe Gln Trp Ala Ile Lys Ala Phe Gln Glu Val Leu Tyr Val Asp
145                 150                 155                 160 
Pro Ser Phe Cys Arg Ala Lys Glu Ile His Leu Arg Val Gly Leu Met
                165                 170                 175     
Phe Lys Val Asn Thr Asp Tyr Glu Ser Ser Leu Lys His Phe Gln Leu
            180                 185                 190         
Ala Leu Val Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln
        195                 200                 205             
Phe His Ile Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala
    210                 215                 220                 
Lys Glu Ala Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Ser Ala Gln
225                 230                 235                 240 
Val Lys Ala Thr Val Leu Gln Gln Leu Gly Trp Met His His Thr Val
                245                 250                 255     
Asp Leu Leu Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr
            260                 265                 270         
Leu Gln Lys Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr
        275                 280                 285             
Phe Leu Gly Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe
    290                 295                 300                 
Ile Ser Tyr Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr
305                 310                 315                 320 
Trp Cys Ser Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp
                325                 330                 335     
Ala Leu Gln Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala
            340                 345                 350         
Ala Ala Trp Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro
        355                 360                 365             
Gln Asp Ala Ile Lys Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys
    370                 375                 380                 
Ser Asn Thr Ser Ala Leu Ala Ala Arg Ile Lys Tyr Leu Gln Ala Gln
385                 390                 395                 400 
Leu Cys Asn Leu Pro Gln Gly Ser Leu Gln Asn Lys Thr Lys Leu Leu
                405                 410                 415     
Pro Ser Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr
            420                 425                 430         
Ser Arg Gln Gly Ala Met Asn Thr Ala Gln Gln Asn Thr Ser Asp Asn
        435                 440                 445             
Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala
    450                 455                 460                 
His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu
465                 470                 475                 480 
Arg Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu
                485                 490                 495     
Gln Leu Glu Ser Gln Phe Val Leu Met Gln Gln His Gln Met Arg Pro
            500                 505                 510         
Thr Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr
        515                 520                 525             
Ala Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln
    530                 535                 540                 
Leu Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro
545                 550                 555                 560 
Ala Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His
                565                 570                 575     
Val Pro Cys Ser Thr Ser Arg Thr Arg Gly Ser Thr Asp Thr Ile Leu
            580                 585                 590         
Ile Gly Asn Asn His Ile Thr Gly Asn Gly Ser Asn Gly Asn Val Pro
        595                 600                 605             
Tyr Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu
    610                 615                 620                 
Thr Ser Ser Ala Lys Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr
625                 630                 635                 640 
Gln Gly Leu His Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly
                645                 650                 655     
Glu Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala
            660                 665                 670         
Gly Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn
        675                 680                 685             
Ser Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala
    690                 695                 700                 
Thr Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro
705                 710                 715                 720 
Ser Gly Asn Ile Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu
                725                 730                 735     
Thr Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His
            740                 745                 750         
Gln Met Thr Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys
        755                 760                 765             
Ser Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu
    770                 775                 780                 
Met Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val
785                 790                 795                 800 
Asn Asn Ile His Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala
                805                 810                 815     
Ser Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser
            820                 825                 830         
Thr Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His
        835                 840                 845             
Ser Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser
    850                 855                 860                 
Pro Met Lys Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln
865                 870                 875                 880 
Ile Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val
                885                 890                 895     
Leu Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser
            900                 905                 910         
Ile Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr
        915                 920                 925             
Pro Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr
    930                 935                 940                 
Leu Glu Asn Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys
945                 950                 955                 960 
Thr Asn Pro Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala
                965                 970                 975     
Leu Lys Leu Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala
            980                 985                 990         
Asn Asn Glu His Met Val Glu Val Arg Thr Gln Leu Leu Gln Pro Ala
        995                 1000                1005            
Asp Glu Asn Trp Asp Pro Thr Gly Thr Lys Lys Ile Trp His Cys Glu
    1010                1015                1020                
Ser Asn Arg Ser His Thr Thr Ile Ala Lys Tyr Ala Gln Tyr Gln Ala
1025                1030                1035               1040 
Ser Ser Phe Gln Glu Ser Leu Arg Glu Glu Asn Glu Lys Arg Ser His
                1045                1050                1055    
His Lys Asp His Ser Asp Ser Glu Ser Thr Ser Ser Asp Asn Ser Gly
            1060                1065                1070        
Arg Arg Arg Lys Gly Pro Phe Lys Thr Ile Lys Phe Gly Thr Asn Ile
        1075                1080                1085            
Asp Leu Ser Asp Asp Lys Lys Trp Lys Leu Gln Leu His Glu Leu Thr
    1090                1095                1100                
Lys Leu Pro Ala Phe Val Arg Val Val Ser Ala Gly Asn Leu Leu Ser
1105                1110                1115               1120 
His Val Gly His Thr Ile Leu Gly Met Asn Thr Val Gln Leu Tyr Met
                1125                1130                1135    
Lys Val Pro Gly Ser Arg Thr Pro Gly His Gln Glu Asn Asn Asn Phe
            1140                1145                1150        
Cys Ser Val Asn Ile Asn Ile Gly Pro Gly Asp Cys Glu Trp Phe Val
        1155                1160                1165            
Val Pro Glu Gly Tyr Trp Gly Val Leu Asn Asp Phe Cys Glu Lys Asn
    1170                1175                1180                
Asn Leu Asn Phe Leu Met Gly Ser Trp Trp Pro Asn Leu Glu Asp Leu
1185                1190                1195               1200 
Tyr Glu Ala Asn Val Pro Val Tyr Arg Phe Ile Gln Arg Pro Gly Asp
                1205                1210                1215    
Leu Val Trp Ile Asn Ala Gly Thr Val His Trp Val Gln Ala Ile Gly
            1220                1225                1230        
Trp Cys Asn Asn Ile Ala Trp Asn Val Gly Pro Leu Thr Ala Cys Gln
        1235                1240                1245            
Tyr Lys Leu Ala Val Glu Arg Tyr Glu Trp Asn Lys Leu Gln Ser Val
    1250                1255                1260                
Lys Ser Ile Val Pro Met Val His Leu Ser Trp Asn Met Ala Arg Asn
1265                1270                1275               1280 
Ile Lys Val Ser Asp Pro Lys Leu Phe Glu Met Ile Lys Tyr Cys Leu
                1285                1290                1295    
Leu Arg Thr Leu Lys Gln Cys Gln Thr Leu Arg Glu Ala Leu Ile Ala
            1300                1305                1310        
Ala Gly Lys Glu Ile Ile Trp His Gly Arg Thr Lys Glu Glu Pro Ala
        1315                1320                1325            
His Tyr Cys Ser Ile Cys Glu Val Glu Val Phe Asp Leu Leu Phe Val
    1330                1335                1340                
Thr Asn Glu Ser Asn Ser Arg Lys Thr Tyr Ile Val His Cys Gln Asp
1345                1350                1355               1360 
Cys Ala Arg Lys Thr Ser Gly Asn Leu Glu Asn Phe Val Val Leu Glu
                1365                1370                1375    
Gln Tyr Lys Met Glu Asp Leu Met Gln Val Tyr Asp Gln Phe Thr Leu
            1380                1385                1390        
Ala Pro Pro Leu Pro Ser Ala Ser Ser
        1395                1400    


<210> 12
<211> 3896
<212> DNA
<213> Homo sapiens

<400> 12
ccttccgcag ctgccgcttc agtccgaagg aggaagggaa ccaacccact ttctcggcgc 60
cgcggctctt ttctaaaagt aatgtgaaaa cctttgcatc ttctgatagt ctagccaagg 120
tccaagaagt agcaagctgg cttttggaaa tgaatcagga actgctctct gtgggcagca 180
aaagacgacg aactggaggc tctctgagag gtaacccttc ctcaagccag gtagatgaag 240
aacagatgaa tcgtgtggta gaggaggaac agcaacagca actcagacaa caagaggagg 300
agcacactgc aaggaatggt gaagttgttg gagtagaacc tagacctgga ggccaaaatg 360
attcccagca aggacagttg gaagaaaaca ataatagatt tatttcggta gatgaggact 420
cctcaggaaa ccaagaagaa caagaggaag atgaagaaca tgctggtgaa caagatgagg 480
aggatgagga ggaggaggag atggaccagg agagtgacga ttttgatcag tctgatgata 540
gtagcagaga agatgaacat acacatacta acagtgtcac gaactccagt agtattgtgg 600
acctgcccgt tcaccaactc tcctccccat tctatacaaa aacaacaaaa atgaaaagaa 660
agttggacca tggttctgag gtccgctctt tttctttggg aaagaaacca tgcaaagtct 720
cagaatatac aagtaccact gggcttgtac catgttcagc aacaccaaca acttttgggg 780
acctcagagc agccaatggc caagggcaac aacgacgccg aattacatct gtccagccac 840
ctacaggcct ccaggaatgg ctaaaaatgt ttcagagctg gagtggacca gagaaattgc 900
ttgctttaga tgaactcatt gatagttgtg aaccaacaca agtaaaacat atgatgcaag 960
tgatagaacc ccagtttcaa cgagacttca tttcattgct ccctaaagag ttggcactct 1020
atgtgctttc attcctggaa cccaaagacc tgctacaagc agctcagaca tgtcgctact 1080
ggagaatttt ggctgaagac aaccttctct ggagagagaa atgcaaagaa gaggggattg 1140
atgaaccatt gcacatcaag agaagaaaag taataaaacc aggtttcata cacagtccat 1200
ggaaaagtgc atacatcaga cagcacagaa ttgatactaa ctggaggcga ggagaactca 1260
aatctcctaa ggtgctgaaa ggacatgatg atcatgtgat cacatgctta cagttttgtg 1320
gtaaccgaat agttagtggt tctgatgaca acactttaaa agtttggtca gcagtcacag 1380
gcaaatgtct gagaacatta gtgggacata caggtggagt atggtcatca caaatgagag 1440
acaacatcat cattagtgga tctacagatc ggacactcaa agtgtggaat gcagagactg 1500
gagaatgtat acacacctta tatgggcata cttccactgt gcgttgtatg catcttcatg 1560
aaaaaagagt tgttagcggt tctcgagatg ccactcttag ggtttgggat attgagacag 1620
gccagtgttt acatgttttg atgggtcatg ttgcagcagt ccgctgtgtt caatatgatg 1680
gcaggagggt tgttagtgga gcatatgatt ttatggtaaa ggtgtgggat ccagagactg 1740
aaacctgtct acacacgttg caggggcata ctaatagagt ctattcatta cagtttgatg 1800
gtatccatgt ggtgagtgga tctcttgata catcaatccg tgtttgggat gtggagacag 1860
ggaattgcat tcacacgtta acagggcacc agtcgttaac aagtggaatg gaactcaaag 1920
acaatattct tgtctctggg aatgcagatt ctacagttaa aatctgggat atcaaaacag 1980
gacagtgttt acaaacattg caaggtccca acaagcatca gagtgctgtg acctgtttac 2040
agttcaacaa gaactttgta attaccagct cagatgatgg aactgtaaaa ctatgggact 2100
tgaaaacggg tgaatttatt cgaaacctag tcacattgga gagtgggggg agtgggggag 2160
ttgtgtggcg gatcagagcc tcaaacacaa agctggtgtg tgcagttggg agtcggaatg 2220
ggactgaaga aaccaagctg ctggtgctgg actttgatgt ggacatgaag tgaagagcag 2280
aaaagatgaa tttgtccaat tgtgtagacg atatactccc tgcccttccc cctgcaaaaa 2340
gaaaaaaaga aaagaaaaag aaaaaaatcc cttgttctca gtggtgcagg atgttggctt 2400
ggggcaacag attgaaaaga cctacagact aagaaggaaa agaagaagag atgacaaacc 2460
ataactgaca agagaggcgt ctgctgtctc atcacataaa aggcttcact tttgactgag 2520
ggcagctttg caaaatgaga ctttctaaat caaaccaggt gcaattattt ctttattttc 2580
ttctccagtg gtcattgggc agtgttaatg ctgaaacatc attacagatt ctgctagcct 2640
gttcttttac cactgacagc tagacaccta gaaaggaact gcaataatat caaaacaagt 2700
actggttgac tttctaatta gagagcatct gcaacaaaaa gtcatttttc tggagtggaa 2760
aagcttaaaa aaattactgt gaattgtttt tgtacagtta tcatgaaaag cttttttttt 2820
tttttttttg ccaaccattg ccaatgtcaa tcaatcacag tattagcctc tgttaatcta 2880
tttactgttg cttccatata cattcttcaa tgcatatgtt gctcaaaggt ggcaagttgt 2940
cctgggttct gtgagtcctg agatggattt aattcttgat gctggtgcta gaagtaggtc 3000
ttcaaatatg ggattgttgt cccaaccctg tactgtactc ccagtggcca aacttattta 3060
tgctgctaaa tgaaagaaag aaaaaagcaa attatttttt tttatttttt ttctgctgtg 3120
acgttttagt cccagactga attccaaatt tgctctagtt tggttatgga aaaaagactt 3180
tttgccactg aaacttgagc catctgtgcc tctaagaggc tgagaatgga agagtttcag 3240
ataataaaga gtgaagtttg cctgcaagta aagaattgag agtgtgtgca aagcttattt 3300
tcttttatct gggcaaaaat taaaacacat tccttggaac agagctatta cttgcctgtt 3360
ctgtggagaa acttttcttt ttgagggctg tggtgaatgg atgaacgtac atcgtaaaac 3420
tgacaaaata ttttaaaaat atataaaaca caaaattaaa ataaagttgc tggtcagtct 3480
tagtgtttta cagtatttgg gaaaacaact gttacagttt tattgctctg agtaactgac 3540
aaagcagaaa ctattcagtt tttgtagtaa aggcgtcaca tgcaaacaaa caaaatgaat 3600
gaaacagtca aatggtttgc ctcattctcc aagagccaca actcaagctg aactgtgaaa 3660
gtggtttaac actgtatcct aggcgatctt ttttcctcct tctgtttatt tttttgtttg 3720
ttttatttat agtctgattt aaaacaatca gattcaagtt ggttaatttt agttatgtaa 3780
caacctgaca tgatggagga aaacaacctt taaagggatt gtgtctatgg tttgattcac 3840
ttagaaattt tattttctta taacttaagt gcaataaaat gtgttttttc atgtta     3896

<210> 13
<211> 2124
<212> DNA
<213> Homo sapiens

<400> 13
atgaatcagg aactgctctc tgtgggcagc aaaagacgac gaactggagg ctctctgaga 60
ggtaaccctt cctcaagcca ggtagatgaa gaacagatga atcgtgtggt agaggaggaa 120
cagcaacagc aactcagaca acaagaggag gagcacactg caaggaatgg tgaagttgtt 180
ggagtagaac ctagacctgg aggccaaaat gattcccagc aaggacagtt ggaagaaaac 240
aataatagat ttatttcggt agatgaggac tcctcaggaa accaagaaga acaagaggaa 300
gatgaagaac atgctggtga acaagatgag gaggatgagg aggaggagga gatggaccag 360
gagagtgacg attttgatca gtctgatgat agtagcagag aagatgaaca tacacatact 420
aacagtgtca cgaactccag tagtattgtg gacctgcccg ttcaccaact ctcctcccca 480
ttctatacaa aaacaacaaa aatgaaaaga aagttggacc atggttctga ggtccgctct 540
ttttctttgg gaaagaaacc atgcaaagtc tcagaatata caagtaccac tgggcttgta 600
ccatgttcag caacaccaac aacttttggg gacctcagag cagccaatgg ccaagggcaa 660
caacgacgcc gaattacatc tgtccagcca cctacaggcc tccaggaatg gctaaaaatg 720
tttcagagct ggagtggacc agagaaattg cttgctttag atgaactcat tgatagttgt 780
gaaccaacac aagtaaaaca tatgatgcaa gtgatagaac cccagtttca acgagacttc 840
atttcattgc tccctaaaga gttggcactc tatgtgcttt cattcctgga acccaaagac 900
ctgctacaag cagctcagac atgtcgctac tggagaattt tggctgaaga caaccttctc 960
tggagagaga aatgcaaaga agaggggatt gatgaaccat tgcacatcaa gagaagaaaa 1020
gtaataaaac caggtttcat acacagtcca tggaaaagtg catacatcag acagcacaga 1080
attgatacta actggaggcg aggagaactc aaatctccta aggtgctgaa aggacatgat 1140
gatcatgtga tcacatgctt acagttttgt ggtaaccgaa tagttagtgg ttctgatgac 1200
aacactttaa aagtttggtc agcagtcaca ggcaaatgtc tgagaacatt agtgggacat 1260
acaggtggag tatggtcatc acaaatgaga gacaacatca tcattagtgg atctacagat 1320
cggacactca aagtgtggaa tgcagagact ggagaatgta tacacacctt atatgggcat 1380
acttccactg tgcgttgtat gcatcttcat gaaaaaagag ttgttagcgg ttctcgagat 1440
gccactctta gggtttggga tattgagaca ggccagtgtt tacatgtttt gatgggtcat 1500
gttgcagcag tccgctgtgt tcaatatgat ggcaggaggg ttgttagtgg agcatatgat 1560
tttatggtaa aggtgtggga tccagagact gaaacctgtc tacacacgtt gcaggggcat 1620
actaatagag tctattcatt acagtttgat ggtatccatg tggtgagtgg atctcttgat 1680
acatcaatcc gtgtttggga tgtggagaca gggaattgca ttcacacgtt aacagggcac 1740
cagtcgttaa caagtggaat ggaactcaaa gacaatattc ttgtctctgg gaatgcagat 1800
tctacagtta aaatctggga tatcaaaaca ggacagtgtt tacaaacatt gcaaggtccc 1860
aacaagcatc agagtgctgt gacctgttta cagttcaaca agaactttgt aattaccagc 1920
tcagatgatg gaactgtaaa actatgggac ttgaaaacgg gtgaatttat tcgaaaccta 1980
gtcacattgg agagtggggg gagtggggga gttgtgtggc ggatcagagc ctcaaacaca 2040
aagctggtgt gtgcagttgg gagtcggaat gggactgaag aaaccaagct gctggtgctg 2100
gactttgatg tggacatgaa gtga                                        2124

<210> 14
<211> 707
<212> PRT
<213> Homo sapiens

<400> 14
Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly
 1               5                  10                  15      
Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln
            20                  25                  30          
Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln
        35                  40                  45              
Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro
    50                  55                  60                  
Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn
65                  70                  75                  80  
Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu
                85                  90                  95      
Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp
            100                 105                 110         
Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser
        115                 120                 125             
Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr
    130                 135                 140                 
Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro
145                 150                 155                 160 
Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser
                165                 170                 175     
Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu
            180                 185                 190         
Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr
        195                 200                 205             
Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg
    210                 215                 220                 
Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met
225                 230                 235                 240 
Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu
                245                 250                 255     
Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile
            260                 265                 270         
Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu
        275                 280                 285             
Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala
    290                 295                 300                 
Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu
305                 310                 315                 320 
Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile
                325                 330                 335     
Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys
            340                 345                 350         
Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly
        355                 360                 365             
Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile
    370                 375                 380                 
Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp
385                 390                 395                 400 
Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr
                405                 410                 415     
Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn
            420                 425                 430         
Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala
        435                 440                 445             
Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val
    450                 455                 460                 
Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp
465                 470                 475                 480 
Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val
                485                 490                 495     
Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg
            500                 505                 510         
Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro
        515                 520                 525             
Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val
    530                 535                 540                 
Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp
545                 550                 555                 560 
Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr
                565                 570                 575     
Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn
            580                 585                 590         
Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile
        595                 600                 605             
Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln
    610                 615                 620                 
Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser
625                 630                 635                 640 
Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe
                645                 650                 655     
Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val
            660                 665                 670         
Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser
        675                 680                 685             
Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val
    690                 695                 700                 
Asp Met Lys
705         


<210> 15
<211> 2591
<212> DNA
<213> Homo sapiens

<400> 15
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt 60
ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt 120
gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca 180
gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc 240
tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc 300
ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg 360
gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt 420
ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct 480
gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt 540
cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat 600
gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc 660
cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt 720
gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca 780
tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg 840
acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca 900
ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac 960
catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg 1020
tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg 1080
ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag 1140
ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcagatccg 1200
tgggcgtgag cgcttcgaga tgttccgaga gctgaatgag gccttggaac tcaaggatgc 1260
ccaggctggg aaggagccag gggggagcag ggctcactcc agccacctga agtccaaaaa 1320
gggtcagtct acctcccgcc ataaaaaact catgttcaag acagaagggc ctgactcaga 1380
ctgacattct ccacttcttg ttccccactg acagcctccc acccccatct ctccctcccc 1440
tgccattttg ggttttgggt ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac 1500
ccaggacttc catttgcttt gtcccggggc tccactgaac aagttggcct gcactggtgt 1560
tttgttgtgg ggaggaggat ggggagtagg acataccagc ttagatttta aggtttttac 1620
tgtgagggat gtttgggaga tgtaagaaat gttcttgcag ttaagggtta gtttacaatc 1680
agccacattc taggtagggg cccacttcac cgtactaacc agggaagctg tccctcactg 1740
ttgaattttc tctaacttca aggcccatat ctgtgaaatg ctggcatttg cacctacctc 1800
acagagtgca ttgtgagggt taatgaaata atgtacatct ggccttgaaa ccacctttta 1860
ttacatgggg tctagaactt gacccccttg agggtgcttg ttccctctcc ctgttggtcg 1920
gtgggttggt agtttctaca gttgggcagc tggttaggta gagggagttg tcaagtctct 1980
gctggcccag ccaaaccctg tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa 2040
tctcacccca tcccacaccc tggaggattt catctcttgt atatgatgat ctggatccac 2100
caagacttgt tttatgctca gggtcaattt cttttttctt tttttttttt ttttttcttt 2160
ttctttgaga ctgggtctcg ctttgttgcc caggctggag tggagtggcg tgatcttggc 2220
ttactgcagc ctttgcctcc ccggctcgag cagtcctgcc tcagcctccg gagtagctgg 2280
gaccacaggt tcatgccacc atggccagcc aacttttgca tgttttgtag agatggggtc 2340
tcacagtgtt gcccaggctg gtctcaaact cctgggctca ggcgatccac ctgtctcagc 2400
ctcccagagt gctgggatta caattgtgag ccaccacgtc cagctggaag ggtcaacatc 2460
ttttacattc tgcaagcaca tctgcatttt caccccaccc ttcccctcct tctccctttt 2520
tatatcccat ttttatatcg atctcttatt ttacaataaa actttgctgc cacctgtgtg 2580
tctgaggggt g                                                      2591

<210> 16
<211> 1182
<212> DNA
<213> Homo sapiens

<400> 16
atggaggagc cgcagtcaga tcctagcgtc gagccccctc tgagtcagga aacattttca 60
gacctatgga aactacttcc tgaaaacaac gttctgtccc ccttgccgtc ccaagcaatg 120
gatgatttga tgctgtcccc ggacgatatt gaacaatggt tcactgaaga cccaggtcca 180
gatgaagctc ccagaatgcc agaggctgct ccccgcgtgg cccctgcacc agcagctcct 240
acaccggcgg cccctgcacc agccccctcc tggcccctgt catcttctgt cccttcccag 300
aaaacctacc agggcagcta cggtttccgt ctgggcttct tgcattctgg gacagccaag 360
tctgtgactt gcacgtactc ccctgccctc aacaagatgt tttgccaact ggccaagacc 420
tgccctgtgc agctgtgggt tgattccaca cccccgcccg gcacccgcgt ccgcgccatg 480
gccatctaca agcagtcaca gcacatgacg gaggttgtga ggcgctgccc ccaccatgag 540
cgctgctcag atagcgatgg tctggcccct cctcagcatc ttatccgagt ggaaggaaat 600
ttgcgtgtgg agtatttgga tgacagaaac acttttcgac atagtgtggt ggtgccctat 660
gagccgcctg aggttggctc tgactgtacc accatccact acaactacat gtgtaacagt 720
tcctgcatgg gcggcatgaa ccggaggccc atcctcacca tcatcacact ggaagactcc 780
agtggtaatc tactgggacg gaacagcttt gaggtgcgtg tttgtgcctg tcctgggaga 840
gaccggcgca cagaggaaga gaatctccgc aagaaagggg agcctcacca cgagctgccc 900
ccagggagca ctaagcgagc actgcccaac aacaccagct cctctcccca gccaaagaag 960
aaaccactgg atggagaata tttcaccctt cagatccgtg ggcgtgagcg cttcgagatg 1020
ttccgagagc tgaatgaggc cttggaactc aaggatgccc aggctgggaa ggagccaggg 1080
gggagcaggg ctcactccag ccacctgaag tccaaaaagg gtcagtctac ctcccgccat 1140
aaaaaactca tgttcaagac agaagggcct gactcagact ga                    1182

<210> 17
<211> 393
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln
 1               5                  10                  15      
Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu
            20                  25                  30          
Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp
        35                  40                  45              
Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro
    50                  55                  60                  
Arg Met Pro Glu Ala Ala Pro Arg Val Ala Pro Ala Pro Ala Ala Pro
65                  70                  75                  80  
Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser
                85                  90                  95      
Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly
            100                 105                 110         
Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro
        115                 120                 125             
Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln
    130                 135                 140                 
Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met
145                 150                 155                 160 
Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys
                165                 170                 175     
Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln
            180                 185                 190         
His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp
        195                 200                 205             
Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu
    210                 215                 220                 
Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser
225                 230                 235                 240 
Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr
                245                 250                 255     
Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val
            260                 265                 270         
Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn
        275                 280                 285             
Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr
    290                 295                 300                 
Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys
305                 310                 315                 320 
Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu
                325                 330                 335     
Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp
            340                 345                 350         
Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His
        355                 360                 365             
Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met
    370                 375                 380                 
Phe Lys Thr Glu Gly Pro Asp Ser Asp
385                 390             


<210> 18
<211> 1267
<212> DNA
<213> Homo sapiens

<400> 18
cgagggctgc ttccggctgg tgcccccggg ggagacccaa cctggggcga cttcaggggt 60
gccacattcg ctaagtgctc ggagttaata gcacctcctc cgagcactcg ctcacggcgt 120
ccccttgcct ggaaagatac cgcggtccct ccagaggatt tgagggacag ggtcggaggg 180
ggctcttccg ccagcaccgg aggaagaaag aggaggggct ggctggtcac cagagggtgg 240
ggcggaccgc gtgcgctcgg cggctgcgga gagggggaga gcaggcagcg ggcggcgggg 300
agcagcatgg agccggcggc ggggagcagc atggagcctt cggctgactg gctggccacg 360
gccgcggccc ggggtcgggt agaggaggtg cgggcgctgc tggaggcggg ggcgctgccc 420
aacgcaccga atagttacgg tcggaggccg atccaggtca tgatgatggg cagcgcccga 480
gtggcggagc tgctgctgct ccacggcgcg gagcccaact gcgccgaccc cgccactctc 540
acccgacccg tgcacgacgc tgcccgggag ggcttcctgg acacgctggt ggtgctgcac 600
cgggccgggg cgcggctgga cgtgcgcgat gcctggggcc gtctgcccgt ggacctggct 660
gaggagctgg gccatcgcga tgtcgcacgg tacctgcgcg cggctgcggg gggcaccaga 720
ggcagtaacc atgcccgcat agatgccgcg gaaggtccct cagacatccc cgattgaaag 780
aaccagagag gctctgagaa acctcgggaa acttagatca tcagtcaccg aaggtcctac 840
agggccacaa ctgcccccgc cacaacccac cccgctttcg tagttttcat ttagaaaata 900
gagcttttaa aaatgtcctg ccttttaacg tagatatatg ccttccccca ctaccgtaaa 960
tgtccattta tatcattttt tatatattct tataaaaatg taaaaaagaa aaacaccgct 1020
tctgcctttt cactgtgttg gagttttctg gagtgagcac tcacgcccta agcgcacatt 1080
catgtgggca tttcttgcga gcctcgcagc ctccggaagc tgtcgacttc atgacaagca 1140
ttttgtgaac tagggaagct caggggggtt actggcttct cttgagtcac actgctagca 1200
aatggcagaa ccaaagctca aataaaaata aaataatttt cattcattca ctcaaaaaaa 1260
aaaaaaa                                                           1267

<210> 19
<211> 471
<212> DNA
<213> Homo sapiens

<400> 19
atggagccgg cggcggggag cagcatggag ccttcggctg actggctggc cacggccgcg 60
gcccggggtc gggtagagga ggtgcgggcg ctgctggagg cgggggcgct gcccaacgca 120
ccgaatagtt acggtcggag gccgatccag gtcatgatga tgggcagcgc ccgagtggcg 180
gagctgctgc tgctccacgg cgcggagccc aactgcgccg accccgccac tctcacccga 240
cccgtgcacg acgctgcccg ggagggcttc ctggacacgc tggtggtgct gcaccgggcc 300
ggggcgcggc tggacgtgcg cgatgcctgg ggccgtctgc ccgtggacct ggctgaggag 360
ctgggccatc gcgatgtcgc acggtacctg cgcgcggctg cggggggcac cagaggcagt 420
aaccatgccc gcatagatgc cgcggaaggt ccctcagaca tccccgattg a          471

<210> 20
<211> 156
<212> PRT
<213> Homo sapiens

<400> 20
Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu
 1               5                  10                  15      
Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu
            20                  25                  30          
Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro
        35                  40                  45              
Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu
    50                  55                  60                  
Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg
65                  70                  75                  80  
Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val
                85                  90                  95      
Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg
            100                 105                 110         
Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg
        115                 120                 125             
Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg
    130                 135                 140                 
Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp
145                 150                 155     


<210> 21
<211> 1164
<212> DNA
<213> Homo Sapiens

<400> 21
cgctcaggga aggcgggtgc gcgcctgcgg ggcggagatg ggcagggggc ggtgcgtggg 60
tcccagtctg cagttaaggg ggcaggagtg gcgctgctca cctctggtgc caaagggcgg 120
cgcagcggct gccgagctcg gccctggagg cggcgagaac atggtgcgca ggttcttggt 180
gaccctccgg attcggcgcg cgtgcggccc gccgcgagtg agggttttcg tggttcacat 240
cccgcggctc acgggggagt gggcagcgcc aggggcgccc gccgctgtgg ccctcgtgct 300
gatgctactg aggagccagc gtctagggca gcagccgctt cctagaagac caggtcatga 360
tgatgggcag cgcccgagtg gcggagctgc tgctgctcca cggcgcggag cccaactgcg 420
ccgaccccgc cactctcacc cgacccgtgc acgacgctgc ccgggagggc ttcctggaca 480
cgctggtggt gctgcaccgg gccggggcgc ggctggacgt gcgcgatgcc tggggccgtc 540
tgcccgtgga cctggctgag gagctgggcc atcgcgatgt cgcacggtac ctgcgcgcgg 600
ctgcgggggg caccagaggc agtaaccatg cccgcataga tgccgcggaa ggtccctcag 660
acatccccga ttgaaagaac cagagaggct ctgagaaacc tcgggaaact tagatcatca 720
gtcaccgaag gtcctacagg gccacaactg cccccgccac aacccacccc gctttcgtag 780
ttttcattta gaaaatagag cttttaaaaa tgtcctgcct tttaacgtag atatatgcct 840
tcccccacta ccgtaaatgt ccatttatat cattttttat atattcttat aaaaatgtaa 900
aaaagaaaaa caccgcttct gccttttcac tgtgttggag ttttctggag tgagcactca 960
cgccctaagc gcacattcat gtgggcattt cttgcgagcc tcgcagcctc cggaagctgt 1020
cgacttcatg acaagcattt tgtgaactag ggaagctcag gggggttact ggcttctctt 1080
gagtcacact gctagcaaat ggcagaacca aagctcaaat aaaaataaaa taattttcat 1140
tcattcactc aaaaaaaaaa aaaa                                        1164

<210> 22
<211> 522
<212> DNA
<213> Homo sapiens

<400> 22
atgggcaggg ggcggtgcgt gggtcccagt ctgcagttaa gggggcagga gtggcgctgc 60
tcacctctgg tgccaaaggg cggcgcagcg gctgccgagc tcggccctgg aggcggcgag 120
aacatggtgc gcaggttctt ggtgaccctc cggattcggc gcgcgtgcgg cccgccgcga 180
gtgagggttt tcgtggttca catcccgcgg ctcacggggg agtgggcagc gccaggggcg 240
cccgccgctg tggccctcgt gctgatgcta ctgaggagcc agcgtctagg gcagcagccg 300
cttcctagaa gaccaggtca tgatgatggg cagcgcccga gtggcggagc tgctgctgct 360
ccacggcgcg gagcccaact gcgccgaccc cgccactctc acccgacccg tgcacgacgc 420
tgcccgggag ggcttcctgg acacgctggt ggtgctgcac cgggccgggg cgcggctgga 480
cgtgcgcgat gcctggggcc gtctgcccgt ggacctggct ga                    522

<210> 23
<211> 173
<212> PRT
<213> Homo sapiens

<400> 23
Met Gly Arg Gly Arg Cys Val Gly Pro Ser Leu Gln Leu Arg Gly Gln
 1               5                  10                  15      
Glu Trp Arg Cys Ser Pro Leu Val Pro Lys Gly Gly Ala Ala Ala Ala
            20                  25                  30          
Glu Leu Gly Pro Gly Gly Gly Glu Asn Met Val Arg Arg Phe Leu Val
        35                  40                  45              
Thr Leu Arg Ile Arg Arg Ala Cys Gly Pro Pro Arg Val Arg Val Phe
    50                  55                  60                  
Val Val His Ile Pro Arg Leu Thr Gly Glu Trp Ala Ala Pro Gly Ala
65                  70                  75                  80  
Pro Ala Ala Val Ala Leu Val Leu Met Leu Leu Arg Ser Gln Arg Leu
                85                  90                  95      
Gly Gln Gln Pro Leu Pro Arg Arg Pro Gly His Asp Asp Gly Gln Arg
            100                 105                 110         
Pro Ser Gly Gly Ala Ala Ala Ala Pro Arg Arg Gly Ala Gln Leu Arg
        115                 120                 125             
Arg Pro Arg His Ser His Pro Thr Arg Ala Arg Arg Cys Pro Gly Gly
    130                 135                 140                 
Leu Pro Gly His Ala Gly Gly Ala Ala Pro Gly Arg Gly Ala Ala Gly
145                 150                 155                 160 
Arg Ala Arg Cys Leu Gly Pro Ser Ala Arg Gly Pro Gly
                165                 170             


<210> 24
<211> 10740
<212> DNA
<213> Homo sapiens

<400> 24
gtattggtgc agcccgccag ggtgtcactg gagacagaat ggaggtgctg ccggactcgg 60
aaatggggtc caagggtagc caaggatggc tgcagcttca tatgatcagt tgttaaagca 120
agttgaggca ctgaagatgg agaactcaaa tcttcgacaa gagctagaag ataattccaa 180
tcatcttaca aaactggaaa ctgaggcatc taatatgaag gaagtactta aacaactaca 240
aggaagtatt gaagatgaag ctatggcttc ttctggacag attgatttat tagagcgtct 300
taaagagctt aacttagata gcagtaattt ccctggagta aaactgcggt caaaaatgtc 360
cctccgttct tatggaagcc gggaaggatc tgtatcaagc cgttctggag agtgcagtcc 420
tgttcctatg ggttcatttc caagaagagg gtttgtaaat ggaagcagag aaagtactgg 480
atatttagaa gaacttgaga aagagaggtc attgcttctt gctgatcttg acaaagaaga 540
aaaggaaaaa gactggtatt acgctcaact tcagaatctc actaaaagaa tagatagtct 600
tcctttaact gaaaattttt ccttacaaac agatatgacc agaaggcaat tggaatatga 660
agcaaggcaa atcagagttg cgatggaaga acaactaggt acctgccagg atatggaaaa 720
acgagcacag cgaagaatag ccagaattca gcaaatcgaa aaggacatac ttcgtatacg 780
acagctttta cagtcccaag caacagaagc agagaggtca tctcagaaca agcatgaaac 840
cggctcacat gatgctgagc ggcagaatga aggtcaagga gtgggagaaa tcaacatggc 900
aacttctggt aatggtcagg gttcaactac acgaatggac catgaaacag ccagtgtttt 960
gagttctagt agcacacact ctgcacctcg aaggctgaca agtcatctgg gaaccaaggt 1020
ggaaatggtg tattcattgt tgtcaatgct tggtactcat gataaggatg atatgtcgcg 1080
aactttgcta gctatgtcta gctcccaaga cagctgtata tccatgcgac agtctggatg 1140
tcttcctctc ctcatccagc ttttacatgg caatgacaaa gactctgtat tgttgggaaa 1200
ttcccggggc agtaaagagg ctcgggccag ggccagtgca gcactccaca acatcattca 1260
ctcacagcct gatgacaaga gaggcaggcg tgaaatccga gtccttcatc ttttggaaca 1320
gatacgcgct tactgtgaaa cctgttggga gtggcaggaa gctcatgaac caggcatgga 1380
ccaggacaaa aatccaatgc cagctcctgt tgaacatcag atctgtcctg ctgtgtgtgt 1440
tctaatgaaa ctttcatttg atgaagagca tagacatgca atgaatgaac tagggggact 1500
acaggccatt gcagaattat tgcaagtgga ctgtgaaatg tatgggctta ctaatgacca 1560
ctacagtatt acactaagac gatatgctgg aatggctttg acaaacttga cttttggaga 1620
tgtagccaac aaggctacgc tatgctctat gaaaggctgc atgagagcac ttgtggccca 1680
actaaaatct gaaagtgaag acttacagca ggttattgcg agtgttttga ggaatttgtc 1740
ttggcgagca gatgtaaata gtaaaaagac gttgcgagaa gttggaagtg tgaaagcatt 1800
gatggaatgt gctttagaag ttaaaaagga atcaaccctc aaaagcgtat tgagtgcctt 1860
atggaatttg tcagcacatt gcactgagaa taaagctgat atatgtgctg tagatggtgc 1920
acttgcattt ttggttggca ctcttactta ccggagccag acaaacactt tagccattat 1980
tgaaagtgga ggtgggatat tacggaatgt gtccagcttg atagctacaa atgaggacca 2040
caggcaaatc ctaagagaga acaactgtct acaaacttta ttacaacact taaaatctca 2100
tagtttgaca atagtcagta atgcatgtgg aactttgtgg aatctctcag caagaaatcc 2160
taaagaccag gaagcattat gggacatggg ggcagttagc atgctcaaga acctcattca 2220
ttcaaagcac aaaatgattg ctatgggaag tgctgcagct ttaaggaatc tcatggcaaa 2280
taggcctgcg aagtacaagg atgccaatat tatgtctcct ggctcaagct tgccatctct 2340
tcatgttagg aaacaaaaag ccctagaagc agaattagat gctcagcact tatcagaaac 2400
ttttgacaat atagacaatt taagtcccaa ggcatctcat cgtagtaagc agagacacaa 2460
gcaaagtctc tatggtgatt atgtttttga caccaatcga catgatgata ataggtcaga 2520
caattttaat actggcaaca tgactgtcct ttcaccatat ttgaatacta cagtgttacc 2580
cagctcctct tcatcaagag gaagcttaga tagttctcgt tctgaaaaag atagaagttt 2640
ggagagagaa cgcggaattg gtctaggcaa ctaccatcca gcaacagaaa atccaggaac 2700
ttcttcaaag cgaggtttgc agatctccac cactgcagcc cagattgcca aagtcatgga 2760
agaagtgtca gccattcata cctctcagga agacagaagt tctgggtcta ccactgaatt 2820
acattgtgtg acagatgaga gaaatgcact tagaagaagc tctgctgccc atacacattc 2880
aaacacttac aatttcacta agtcggaaaa ttcaaatagg acatgttcta tgccttatgc 2940
caaattagaa tacaagagat cttcaaatga tagtttaaat agtgtcagta gtagtgatgg 3000
ttatggtaaa agaggtcaaa tgaaaccctc gattgaatcc tattctgaag atgatgaaag 3060
taagttttgc agttatggtc aatacccagc cgacctagcc cataaaatac atagtgcaaa 3120
tcatatggat gataatgatg gagaactaga tacaccaata aattatagtc ttaaatattc 3180
agatgagcag ttgaactctg gaaggcaaag tccttcacag aatgaaagat gggcaagacc 3240
caaacacata atagaagatg aaataaaaca aagtgagcaa agacaatcaa ggaatcaaag 3300
tacaacttat cctgtttata ctgagagcac tgatgataaa cacctcaagt tccaaccaca 3360
ttttggacag caggaatgtg tttctccata caggtcacgg ggagccaatg gttcagaaac 3420
aaatcgagtg ggttctaatc atggaattaa tcaaaatgta agccagtctt tgtgtcaaga 3480
agatgactat gaagatgata agcctaccaa ttatagtgaa cgttactctg aagaagaaca 3540
gcatgaagaa gaagagagac caacaaatta tagcataaaa tataatgaag agaaacgtca 3600
tgtggatcag cctattgatt atagtttaaa atatgccaca gatattcctt catcacagaa 3660
acagtcattt tcattctcaa agagttcatc tggacaaagc agtaaaaccg aacatatgtc 3720
ttcaagcagt gagaatacgt ccacaccttc atctaatgcc aagaggcaga atcagctcca 3780
tccaagttct gcacagagta gaagtggtca gcctcaaaag gctgccactt gcaaagtttc 3840
ttctattaac caagaaacaa tacagactta ttgtgtagaa gatactccaa tatgtttttc 3900
aagatgtagt tcattatcat ctttgtcatc agctgaagat gaaataggat gtaatcagac 3960
gacacaggaa gcagattctg ctaataccct gcaaatagca gaaataaaag aaaagattgg 4020
aactaggtca gctgaagatc ctgtgagcga agttccagca gtgtcacagc accctagaac 4080
caaatccagc agactgcagg gttctagttt atcttcagaa tcagccaggc acaaagctgt 4140
tgaattttct tcaggagcga aatctccctc caaaagtggt gctcagacac ccaaaagtcc 4200
acctgaacac tatgttcagg agaccccact catgtttagc agatgtactt ctgtcagttc 4260
acttgatagt tttgagagtc gttcgattgc cagctccgtt cagagtgaac catgcagtgg 4320
aatggtaagt ggcattataa gccccagtga tcttccagat agccctggac aaaccatgcc 4380
accaagcaga agtaaaacac ctccaccacc tcctcaaaca gctcaaacca agcgagaagt 4440
acctaaaaat aaagcaccta ctgctgaaaa gagagagagt ggacctaagc aagctgcagt 4500
aaatgctgca gttcagaggg tccaggttct tccagatgct gatactttat tacattttgc 4560
cacggaaagt actccagatg gattttcttg ttcatccagc ctgagtgctc tgagcctcga 4620
tgagccattt atacagaaag atgtggaatt aagaataatg cctccagttc aggaaaatga 4680
caatgggaat gaaacagaat cagagcagcc taaagaatca aatgaaaacc aagagaaaga 4740
ggcagaaaaa actattgatt ctgaaaagga cctattagat gattcagatg atgatgatat 4800
tgaaatacta gaagaatgta ttatttctgc catgccaaca aagtcatcac gtaaagcaaa 4860
aaagccagcc cagactgctt caaaattacc tccacctgtg gcaaggaaac caagtcagct 4920
gcctgtgtac aaacttctac catcacaaaa caggttgcaa ccccaaaagc atgttagttt 4980
tacaccgggg gatgatatgc cacgggtgta ttgtgttgaa gggacaccta taaacttttc 5040
cacagctaca tctctaagtg atctaacaat cgaatcccct ccaaatgagt tagctgctgg 5100
agaaggagtt agaggagggg cacagtcagg tgaatttgaa aaacgagata ccattcctac 5160
agaaggcaga agtacagatg aggctcaagg aggaaaaacc tcatctgtaa ccatacctga 5220
attggatgac aataaagcag aggaaggtga tattcttgca gaatgcatta attctgctat 5280
gcccaaaggg aaaagtcaca agcctttccg tgtgaaaaag ataatggacc aggtccagca 5340
agcatctgcg tcttcttctg cacccaacaa aaatcagtta gatggtaaga aaaagaaacc 5400
aacttcacca gtaaaaccta taccacaaaa tactgaatat aggacacgtg taagaaaaaa 5460
tgcagactca aaaaataatt taaatgctga gagagttttc tcagacaaca aagattcaaa 5520
gaaacagaat ttgaaaaata attccaaggt cttcaatgat aagctcccaa ataatgaaga 5580
tagagtcaga ggaagttttg cttttgattc acctcatcat tacacgccta ttgaaggaac 5640
tccttactgt ttttcacgaa atgattcttt gagttctcta gattttgatg atgatgatgt 5700
tgacctttcc agggaaaagg ctgaattaag aaaggcaaaa gaaaataagg aatcagaggc 5760
taaagttacc agccacacag aactaacctc caaccaacaa tcagctaata agacacaagc 5820
tattgcaaag cagccaataa atcgaggtca gcctaaaccc atacttcaga aacaatccac 5880
ttttccccag tcatccaaag acataccaga cagaggggca gcaactgatg aaaagttaca 5940
gaattttgct attgaaaata ctccggtttg cttttctcat aattcctctc tgagttctct 6000
cagtgacatt gaccaagaaa acaacaataa agaaaatgaa cctatcaaag agactgagcc 6060
ccctgactca cagggagaac caagtaaacc tcaagcatca ggctatgctc ctaaatcatt 6120
tcatgttgaa gataccccag tttgtttctc aagaaacagt tctctcagtt ctcttagtat 6180
tgactctgaa gatgacctgt tgcaggaatg tataagctcc gcaatgccaa aaaagaaaaa 6240
gccttcaaga ctcaagggtg ataatgaaaa acatagtccc agaaatatgg gtggcatatt 6300
aggtgaagat ctgacacttg atttgaaaga tatacagaga ccagattcag aacatggtct 6360
atcccctgat tcagaaaatt ttgattggaa agctattcag gaaggtgcaa attccatagt 6420
aagtagttta catcaagctg ctgctgctgc atgtttatct agacaagctt cgtctgattc 6480
agattccatc ctttccctga aatcaggaat ctctctggga tcaccatttc atcttacacc 6540
tgatcaagaa gaaaaaccct ttacaagtaa taaaggccca cgaattctaa aaccagggga 6600
gaaaagtaca ttggaaacta aaaagataga atctgaaagt aaaggaatca aaggaggaaa 6660
aaaagtttat aaaagtttga ttactggaaa agttcgatct aattcagaaa tttcaggcca 6720
aatgaaacag ccccttcaag caaacatgcc ttcaatctct cgaggcagga caatgattca 6780
tattccagga gttcgaaata gctcctcaag tacaagtcct gtttctaaaa aaggcccacc 6840
ccttaagact ccagcctcca aaagccctag tgaaggtcaa acagccacca cttctcctag 6900
aggagccaag ccatctgtga aatcagaatt aagccctgtt gccaggcaga catcccaaat 6960
aggtgggtca agtaaagcac cttctagatc aggatctaga gattcgaccc cttcaagacc 7020
tgcccagcaa ccattaagta gacctataca gtctcctggc cgaaactcaa tttcccctgg 7080
tagaaatgga ataagtcctc ctaacaaatt atctcaactt ccaaggacat catcccctag 7140
tactgcttca actaagtcct caggttctgg aaaaatgtca tatacatctc caggtagaca 7200
gatgagccaa cagaacctta ccaaacaaac aggtttatcc aagaatgcca gtagtattcc 7260
aagaagtgag tctgcctcca aaggactaaa tcagatgaat aatggtaatg gagccaataa 7320
aaaggtagaa ctttctagaa tgtcttcaac taaatcaagt ggaagtgaat ctgatagatc 7380
agaaagacct gtattagtac gccagtcaac tttcatcaaa gaagctccaa gcccaacctt 7440
aagaagaaaa ttggaggaat ctgcttcatt tgaatctctt tctccatcat ctagaccagc 7500
ttctcccact aggtcccagg cacaaactcc agttttaagt ccttcccttc ctgatatgtc 7560
tctatccaca cattcgtctg ttcaggctgg tggatggcga aaactcccac ctaatctcag 7620
tcccactata gagtataatg atggaagacc agcaaagcgc catgatattg cacggtctca 7680
ttctgaaagt ccttctagac ttccaatcaa taggtcagga acctggaaac gtgagcacag 7740
caaacattca tcatcccttc ctcgagtaag cacttggaga agaactggaa gttcatcttc 7800
aattctttct gcttcatcag aatccagtga aaaagcaaaa agtgaggatg aaaaacatgt 7860
gaactctatt tcaggaacca aacaaagtaa agaaaaccaa gtatccgcaa aaggaacatg 7920
gagaaaaata aaagaaaatg aattttctcc cacaaatagt acttctcaga ccgtttcctc 7980
aggtgctaca aatggtgctg aatcaaagac tctaatttat caaatggcac ctgctgtttc 8040
taaaacagag gatgtttggg tgagaattga ggactgtccc attaacaatc ctagatctgg 8100
aagatctccc acaggtaata ctcccccggt gattgacagt gtttcagaaa aggcaaatcc 8160
aaacattaaa gattcaaaag ataatcaggc aaaacaaaat gtgggtaatg gcagtgttcc 8220
catgcgtacc gtgggtttgg aaaatcgcct gaactccttt attcaggtgg atgcccctga 8280
ccaaaaagga actgagataa aaccaggaca aaataatcct gtccctgtat cagagactaa 8340
tgaaagttct atagtggaac gtaccccatt cagttctagc agctcaagca aacacagttc 8400
acctagtggg actgttgctg ccagagtgac tccttttaat tacaacccaa gccctaggaa 8460
aagcagcgca gatagcactt cagctcggcc atctcagatc ccaactccag tgaataacaa 8520
cacaaagaag cgagattcca aaactgacag cacagaatcc agtggaaccc aaagtcctaa 8580
gcgccattct gggtcttacc ttgtgacatc tgtttaaaag agaggaagaa tgaaactaag 8640
aaaattctat gttaattaca actgctatat agacattttg tttcaaatga aactttaaaa 8700
gactgaaaaa ttttgtaaat aggtttgatt cttgttagag ggtttttgtt ctggaagcca 8760
tatttgatag tatactttgt cttcactggt cttattttgg gaggcactct tgatggttag 8820
gaaaaaaata gtaaagccaa gtatgtttgt acagtatgtt ttacatgtat ttaaagtagc 8880
atcccatccc aacttccttt aattattgct tgtcttaaaa taatgaacac tacagataga 8940
aaatatgata tattgctgtt atcaatcatt tctagattat aaactgacta aacttacatc 9000
agggaaaaat tggtatttat gcaaaaaaaa atgtttttgt ccttgtgagt ccatctaaca 9060
tcataattaa tcatgtggct gtgaaattca cagtaatatg gttcccgatg aacaagttta 9120
cccagcctgc tttgctttac tgcatgaatg aaactgatgg ttcaatttca gaagtaatga 9180
ttaacagtta tgtggtcaca tgatgtgcat agagatagct acagtgtaat aatttacact 9240
attttgtgct ccaaacaaaa caaaaatctg tgtaactgta aaacattgaa tgaaactatt 9300
ttacctgaac tagattttat ctgaaagtag gtagaatttt tgctatgctg taatttgttg 9360
tatattctgg tatttgaggt gagatggctg ctcttttatt aatgagacat gaattgtgtc 9420
tcaacagaaa ctaaatgaac atttcagaat aaattattgc tgtatgtaaa ctgttactga 9480
aattggtatt tgtttgaagg gtcttgtttc acatttgtat taataattgt ttaaaatgcc 9540
tcttttaaaa gcttatataa atttttttct tcagcttcta tgcattaaga gtaaaattcc 9600
tcttactgta ataaaaacaa ttgaagaaga ctgttgccac ttaaccattc catgcgttgg 9660
cacttatcta ttcctgaaat ttcttttatg tgattagctc atcttgattt ttaatatttt 9720
tccacttaaa cttttttttc ttactccact ggagctcagt aaaagtaaat tcatgtaata 9780
gcaatgcaag cagcctagca cagactaagc attgagcata ataggcccac ataatttcct 9840
ctttcttaat attatagaat tctgtacttg aaattgattc ttagacattg cagtctcttc 9900
gaggctttac agtgtaaact gtcttgcccc ttcatcttct tgttgcaact gggtctgaca 9960
tgaacacttt ttatcaccct gtatgttagg gcaagatctc agcagtgaag tataatcagc 10020
actttgccat gctcagaaaa ttcaaatcac atggaacttt agaggtagat ttaatacgat 10080
taagatattc agaagtatat tttagaatcc ctgcctgtta aggaaacttt atttgtggta 10140
ggtacagttc tggggtacat gttaagtgtc cccttataca gtggagggaa gtcttccttc 10200
ctgaaggaaa ataaactgac acttattaac taagataatt tacttaatat atcttccctg 10260
atttgtttta aaagatcaga gggtgactga tgatacatgc atacatattt gttgaataaa 10320
tgaaaattta tttttagtga taagattcat acactctgta tttggggagg gaaaaccttt 10380
ttaagcatgg tggggcactc agataggagt gaatacacct acctggtgcc ttgaaaatca 10440
catcaagtag ttaattatct accccttacc tgtgtttata acttccaggt aatgagaatg 10500
atttttttta aagctaaaat gccagtaaat aaaagtgcta tgacttgagc taagatattt 10560
gactccaatg cctgtactgt gtctactgca ccactttgta aacacttcaa tttactatct 10620
ttgaaatgat tgacctttaa atttttgcca aatgttatct gaaattgtct atgaatacca 10680
tctacttctg ttgttttccc aggcttccat aaacaatgga gatacatgca aaaaaaaaaa 10740




<210> 25
<211> 8532
<212> DNA
<213> Homo sapiens

<400> 25
atggctgcag cttcatatga tcagttgtta aagcaagttg aggcactgaa gatggagaac 60
tcaaatcttc gacaagagct agaagataat tccaatcatc ttacaaaact ggaaactgag 120
gcatctaata tgaaggaagt acttaaacaa ctacaaggaa gtattgaaga tgaagctatg 180
gcttcttctg gacagattga tttattagag cgtcttaaag agcttaactt agatagcagt 240
aatttccctg gagtaaaact gcggtcaaaa atgtccctcc gttcttatgg aagccgggaa 300
ggatctgtat caagccgttc tggagagtgc agtcctgttc ctatgggttc atttccaaga 360
agagggtttg taaatggaag cagagaaagt actggatatt tagaagaact tgagaaagag 420
aggtcattgc ttcttgctga tcttgacaaa gaagaaaagg aaaaagactg gtattacgct 480
caacttcaga atctcactaa aagaatagat agtcttcctt taactgaaaa tttttcctta 540
caaacagata tgaccagaag gcaattggaa tatgaagcaa ggcaaatcag agttgcgatg 600
gaagaacaac taggtacctg ccaggatatg gaaaaacgag cacagcgaag aatagccaga 660
attcagcaaa tcgaaaagga catacttcgt atacgacagc ttttacagtc ccaagcaaca 720
gaagcagaga ggtcatctca gaacaagcat gaaaccggct cacatgatgc tgagcggcag 780
aatgaaggtc aaggagtggg agaaatcaac atggcaactt ctggtaatgg tcagggttca 840
actacacgaa tggaccatga aacagccagt gttttgagtt ctagtagcac acactctgca 900
cctcgaaggc tgacaagtca tctgggaacc aaggtggaaa tggtgtattc attgttgtca 960
atgcttggta ctcatgataa ggatgatatg tcgcgaactt tgctagctat gtctagctcc 1020
caagacagct gtatatccat gcgacagtct ggatgtcttc ctctcctcat ccagctttta 1080
catggcaatg acaaagactc tgtattgttg ggaaattccc ggggcagtaa agaggctcgg 1140
gccagggcca gtgcagcact ccacaacatc attcactcac agcctgatga caagagaggc 1200
aggcgtgaaa tccgagtcct tcatcttttg gaacagatac gcgcttactg tgaaacctgt 1260
tgggagtggc aggaagctca tgaaccaggc atggaccagg acaaaaatcc aatgccagct 1320
cctgttgaac atcagatctg tcctgctgtg tgtgttctaa tgaaactttc atttgatgaa 1380
gagcatagac atgcaatgaa tgaactaggg ggactacagg ccattgcaga attattgcaa 1440
gtggactgtg aaatgtacgg gcttactaat gaccactaca gtattacact aagacgatat 1500
gctggaatgg ctttgacaaa cttgactttt ggagatgtag ccaacaaggc tacgctatgc 1560
tctatgaaag gctgcatgag agcacttgtg gcccaactaa aatctgaaag tgaagactta 1620
cagcaggtta ttgcaagtgt tttgaggaat ttgtcttggc gagcagatgt aaatagtaaa 1680
aagacgttgc gagaagttgg aagtgtgaaa gcattgatgg aatgtgcttt agaagttaaa 1740
aaggaatcaa ccctcaaaag cgtattgagt gccttatgga atttgtcagc acattgcact 1800
gagaataaag ctgatatatg tgctgtagat ggtgcacttg catttttggt tggcactctt 1860
acttaccgga gccagacaaa cactttagcc attattgaaa gtggaggtgg gatattacgg 1920
aatgtgtcca gcttgatagc tacaaatgag gaccacaggc aaatcctaag agagaacaac 1980
tgtctacaaa ctttattaca acacttaaaa tctcatagtt tgacaatagt cagtaatgca 2040
tgtggaactt tgtggaatct ctcagcaaga aatcctaaag accaggaagc attatgggac 2100
atgggggcag ttagcatgct caagaacctc attcattcaa agcacaaaat gattgctatg 2160
ggaagtgctg cagctttaag gaatctcatg gcaaataggc ctgcgaagta caaggatgcc 2220
aatattatgt ctcctggctc aagcttgcca tctcttcatg ttaggaaaca aaaagcccta 2280
gaagcagaat tagatgctca gcacttatca gaaacttttg acaatataga caatttaagt 2340
cccaaggcat ctcatcgtag taagcagaga cacaagcaaa gtctctatgg tgattatgtt 2400
tttgacacca atcgacatga tgataatagg tcagacaatt ttaatactgg caacatgact 2460
gtcctttcac catatttgaa tactacagtg ttacccagct cctcttcatc aagaggaagc 2520
ttagatagtt ctcgttctga aaaagataga agtttggaga gagaacgcgg aattggtcta 2580
ggcaactacc atccagcaac agaaaatcca ggaacttctt caaagcgagg tttgcagatc 2640
tccaccactg cagcccagat tgccaaagtc atggaagaag tgtcagccat tcatacctct 2700
caggaagaca gaagttctgg gtctaccact gaattacatt gtgtgacaga tgagagaaat 2760
gcacttagaa gaagctctgc tgcccataca cattcaaaca cttacaattt cactaagtcg 2820
gaaaattcaa ataggacatg ttctatgcct tatgccaaat tagaatacaa gagatcttca 2880
aatgatagtt taaatagtgt cagtagtagt gatggttatg gtaaaagagg tcaaatgaaa 2940
ccctcgattg aatcctattc tgaagatgat gaaagtaagt tttgcagtta tggtcaatac 3000
ccagccgacc tagcccataa aatacatagt gcaaatcata tggatgataa tgatggagaa 3060
ctagatacac caataaatta tagtcttaaa tattcagatg agcagttgaa ctctggaagg 3120
caaagtcctt cacagaatga aagatgggca agacccaaac acataataga agatgaaata 3180
aaacaaagtg agcaaagaca atcaaggaat caaagtacaa cttatcctgt ttatactgag 3240
agcactgatg ataaacacct caagttccaa ccacattttg gacagcagga atgtgtttct 3300
ccatacaggt cacggggagc caatggttca gaaacaaatc gagtgggttc taatcatgga 3360
attaatcaaa atgtaagcca gtctttgtgt caagaagatg actatgaaga tgataagcct 3420
accaattata gtgaacgtta ctctgaagaa gaacagcatg aagaagaaga gagaccaaca 3480
aattatagca taaaatataa tgaagagaaa cgtcatgtgg atcagcctat tgattatagt 3540
ttaaaatatg ccacagatat tccttcatca cagaaacagt cattttcatt ctcaaagagt 3600
tcatctggac aaagcagtaa aaccgaacat atgtcttcaa gcagtgagaa tacgtccaca 3660
ccttcatcta atgccaagag gcagaatcag ctccatccaa gttctgcaca gagtagaagt 3720
ggtcagcctc aaaaggctgc cacttgcaaa gtttcttcta ttaaccaaga aacaatacag 3780
acttattgtg tagaagatac tccaatatgt ttttcaagat gtagttcatt atcatctttg 3840
tcatcagctg aagatgaaat aggatgtaat cagacgacac aggaagcaga ttctgctaat 3900
accctgcaaa tagcagaaat aaaagaaaag attggaacta ggtcagctga agatcctgtg 3960
agcgaagttc cagcagtgtc acagcaccct agaaccaaat ccagcagact gcagggttct 4020
agtttatctt cagaatcagc caggcacaaa gctgttgaat tttcttcagg agcgaaatct 4080
ccctccaaaa gtggtgctca gacacccaaa agtccacctg aacactatgt tcaggagacc 4140
ccactcatgt ttagcagatg tacttctgtc agttcacttg atagttttga gagtcgttcg 4200
attgccagct ccgttcagag tgaaccatgc agtggaatgg taagtggcat tataagcccc 4260
agtgatcttc cagatagccc tggacaaacc atgccaccaa gcagaagtaa aacacctcca 4320
ccacctcctc aaacagctca aaccaagcga gaagtaccta aaaataaagc acctactgct 4380
gaaaagagag agagtggacc taagcaagct gcagtaaatg ctgcagttca gagggtccag 4440
gttcttccag atgctgatac tttattacat tttgccacgg aaagtactcc agatggattt 4500
tcttgttcat ccagcctgag tgctctgagc ctcgatgagc catttataca gaaagatgtg 4560
gaattaagaa taatgcctcc agttcaggaa aatgacaatg ggaatgaaac agaatcagag 4620
cagcctaaag aatcaaatga aaaccaagag aaagaggcag aaaaaactat tgattctgaa 4680
aaggacctat tagatgattc agatgatgat gatattgaaa tactagaaga atgtattatt 4740
tctgccatgc caacaaagtc atcacgtaaa gcaaaaaagc cagcccagac tgcttcaaaa 4800
ttacctccac ctgtggcaag gaaaccaagt cagctgcctg tgtacaaact tctaccatca 4860
caaaacaggt tgcaacccca aaagcatgtt agttttacac cgggggatga tatgccacgg 4920
gtgtattgtg ttgaagggac acctataaac ttttccacag ctacatctct aagtgatcta 4980
acaatcgaat cccctccaaa tgagttagct gctggagaag gagttagagg aggagcacag 5040
tcaggtgaat ttgaaaaacg agataccatt cctacagaag gcagaagtac agatgaggct 5100
caaggaggaa aaacctcatc tgtaaccata cctgaattgg atgacaataa agcagaggaa 5160
ggtgatattc ttgcagaatg cattaattct gctatgccca aagggaaaag tcacaagcct 5220
ttccgtgtga aaaagataat ggaccaggtc cagcaagcat ctgcgtcgtc ttctgcaccc 5280
aacaaaaatc agttagatgg taagaaaaag aaaccaactt caccagtaaa acctatacca 5340
caaaatactg aatataggac acgtgtaaga aaaaatgcag actcaaaaaa taatttaaat 5400
gctgagagag ttttctcaga caacaaagat tcaaagaaac agaatttgaa aaataattcc 5460
aaggacttca atgataagct cccaaataat gaagatagag tcagaggaag ttttgctttt 5520
gattcacctc atcattacac gcctattgaa ggaactcctt actgtttttc acgaaatgat 5580
tctttgagtt ctctagattt tgatgatgat gatgttgacc tttccaggga aaaggctgaa 5640
ttaagaaagg caaaagaaaa taaggaatca gaggctaaag ttaccagcca cacagaacta 5700
acctccaacc aacaatcagc taataagaca caagctattg caaagcagcc aataaatcga 5760
ggtcagccta aacccatact tcagaaacaa tccacttttc cccagtcatc caaagacata 5820
ccagacagag gggcagcaac tgatgaaaag ttacagaatt ttgctattga aaatactcca 5880
gtttgctttt ctcataattc ctctctgagt tctctcagtg acattgacca agaaaacaac 5940
aataaagaaa atgaacctat caaagagact gagccccctg actcacaggg agaaccaagt 6000
aaacctcaag catcaggcta tgctcctaaa tcatttcatg ttgaagatac cccagtttgt 6060
ttctcaagaa acagttctct cagttctctt agtattgact ctgaagatga cctgttgcag 6120
gaatgtataa gctccgcaat gccaaaaaag aaaaagcctt caagactcaa gggtgataat 6180
gaaaaacata gtcccagaaa tatgggtggc atattaggtg aagatctgac acttgatttg 6240
aaagatatac agagaccaga ttcagaacat ggtctatccc ctgattcaga aaattttgat 6300
tggaaagcta ttcaggaagg tgcaaattcc atagtaagta gtttacatca agctgctgct 6360
gctgcatgtt tatctagaca agcttcgtct gattcagatt ccatcctttc cctgaaatca 6420
ggaatctctc tgggatcacc atttcatctt acacctgatc aagaagaaaa accctttaca 6480
agtaataaag gcccacgaat tctaaaacca ggggagaaaa gtacattgga aactaaaaag 6540
atagaatctg aaagtaaagg aatcaaagga ggaaaaaaag tttataaaag tttgattact 6600
ggaaaagttc gatctaattc agaaatttca ggccaaatga aacagcccct tcaagcaaac 6660
atgccttcaa tctctcgagg caggacaatg attcatattc caggagttcg aaatagctcc 6720
tcaagtacaa gtcctgtttc taaaaaaggc ccacccctta agactccagc ctccaaaagc 6780
cctagtgaag gtcaaacagc caccacttct cctagaggag ccaagccatc tgtgaaatca 6840
gaattaagcc ctgttgccag gcagacatcc caaataggtg ggtcaagtaa agcaccttct 6900
agatcaggat ctagagattc gaccccttca agacctgccc agcaaccatt aagtagacct 6960
atacagtctc ctggccgaaa ctcaatttcc cctggtagaa atggaataag tcctcctaac 7020
aaattatctc aacttccaag gacatcatcc cctagtactg cttcaactaa gtcctcaggt 7080
tctggaaaaa tgtcatatac atctccaggt agacagatga gccaacagaa ccttaccaaa 7140
caaacaggtt tatccaagaa tgccagtagt attccaagaa gtgagtctgc ctccaaagga 7200
ctaaatcaga tgaataatgg taatggagcc aataaaaagg tagaactttc tagaatgtct 7260
tcaactaaat caagtggaag tgaatctgat agatcagaaa gacctgtatt agtacgccag 7320
tcaactttca tcaaagaagc tccaagccca accttaagaa gaaaattgga ggaatctgct 7380
tcatttgaat ctctttctcc atcatctaga ccagcttctc ccactaggtc ccaggcacaa 7440
actccagttt taagtccttc ccttcctgat atgtctctat ccacacattc gtctgttcag 7500
gctggtggat ggcgaaaact cccacctaat ctcagtccca ctatagagta taatgatgga 7560
agaccagcaa agcgccatga tattgcacgg tctcattctg aaagtccttc tagacttcca 7620
atcaataggt caggaacctg gaaacgtgag cacagcaaac attcatcatc ccttcctcga 7680
gtaagcactt ggagaagaac tggaagttca tcttcaattc tttctgcttc atcagaatcc 7740
agtgaaaaag caaaaagtga ggatgaaaaa catgtgaact ctatttcagg aaccaaacaa 7800
agtaaagaaa accaagtatc cgcaaaagga acatggagaa aaataaaaga aaatgaattt 7860
tctcccacaa atagtacttc tcagaccgtt tcctcaggtg ctacaaatgg tgctgaatca 7920
aagactctaa tttatcaaat ggcacctgct gtttctaaaa cagaggatgt ttgggtgaga 7980
attgaggact gtcccattaa caatcctaga tctggaagat ctcccacagg taatactccc 8040
ccggtgattg acagtgtttc agaaaaggca aatccaaaca ttaaagattc aaaagataat 8100
caggcaaaac aaaatgtggg taatggcagt gttcccatgc gtaccgtggg tttggaaaat 8160
cgcctgaact cctttattca ggtggatgcc cctgaccaaa aaggaactga gataaaacca 8220
ggacaaaata atcctgtccc tgtatcagag actaatgaaa gttctatagt ggaacgtacc 8280
ccattcagtt ctagcagctc aagcaaacac agttcaccta gtgggactgt tgctgccaga 8340
gtgactcctt ttaattacaa cccaagccct aggaaaagca gcgcagatag cacttcagct 8400
cggccatctc agatcccaac tccagtgaat aacaacacaa agaagcgaga ttccaaaact 8460
gacagcacag aatccagtgg aacccaaagt cctaagcgcc attctgggtc ttaccttgtg 8520
acatctgttt aa                                                     8532



<210> 26
<211> 2843
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu
 1               5                  10                  15      
Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn
            20                  25                  30          
His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu
        35                  40                  45              
Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly
    50                  55                  60                  
Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser
65                  70                  75                  80  
Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr
                85                  90                  95      
Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro
            100                 105                 110         
Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg
        115                 120                 125             
Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu
    130                 135                 140                 
Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala
145                 150                 155                 160 
Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu
                165                 170                 175     
Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu
            180                 185                 190         
Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln
        195                 200                 205             
Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile
    210                 215                 220                 
Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr
225                 230                 235                 240 
Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp
                245                 250                 255     
Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala
            260                 265                 270         
Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr
        275                 280                 285             
Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu
    290                 295                 300                 
Thr Ser His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser
305                 310                 315                 320 
Met Leu Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala
                325                 330                 335     
Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys
            340                 345                 350         
Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val
        355                 360                 365             
Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser
    370                 375                 380                 
Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly
385                 390                 395                 400 
Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr
                405                 410                 415     
Cys Glu Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp
            420                 425                 430         
Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro
        435                 440                 445             
Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His
    450                 455                 460                 
Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln
465                 470                 475                 480 
Val Asp Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr
                485                 490                 495     
Leu Arg Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp
            500                 505                 510         
Val Ala Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala
        515                 520                 525             
Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile
    530                 535                 540                 
Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys
545                 550                 555                 560 
Lys Thr Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala
                565                 570                 575     
Leu Glu Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu
            580                 585                 590         
Trp Asn Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala
        595                 600                 605             
Val Asp Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser
    610                 615                 620                 
Gln Thr Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg
625                 630                 635                 640 
Asn Val Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu
                645                 650                 655     
Arg Glu Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His
            660                 665                 670         
Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser
        675                 680                 685             
Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val
    690                 695                 700                 
Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met
705                 710                 715                 720 
Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys
                725                 730                 735     
Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu
            740                 745                 750         
His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His
        755                 760                 765             
Leu Ser Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser
    770                 775                 780                 
His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val
785                 790                 795                 800 
Phe Asp Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr
                805                 810                 815     
Gly Asn Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro
            820                 825                 830         
Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys
        835                 840                 845             
Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His
    850                 855                 860                 
Pro Ala Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile
865                 870                 875                 880 
Ser Thr Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala
                885                 890                 895     
Ile His Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu
            900                 905                 910         
His Cys Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala
        915                 920                 925             
His Thr His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn
    930                 935                 940                 
Arg Thr Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser
945                 950                 955                 960 
Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg
                965                 970                 975     
Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser
            980                 985                 990         
Lys Phe Cys Ser Tyr Gly Gln Tyr Pro Ala Asp Leu Ala His Lys Ile
        995                 1000                1005            
His Ser Ala Asn His Met Asp Asp Asn Asp Gly Glu Leu Asp Thr Pro
    1010                1015                1020                
Ile Asn Tyr Ser Leu Lys Tyr Ser Asp Glu Gln Leu Asn Ser Gly Arg
1025                1030                1035               1040 
Gln Ser Pro Ser Gln Asn Glu Arg Trp Ala Arg Pro Lys His Ile Ile
                1045                1050                1055    
Glu Asp Glu Ile Lys Gln Ser Glu Gln Arg Gln Ser Arg Asn Gln Ser
            1060                1065                1070        
Thr Thr Tyr Pro Val Tyr Thr Glu Ser Thr Asp Asp Lys His Leu Lys
        1075                1080                1085            
Phe Gln Pro His Phe Gly Gln Gln Glu Cys Val Ser Pro Tyr Arg Ser
    1090                1095                1100                
Arg Gly Ala Asn Gly Ser Glu Thr Asn Arg Val Gly Ser Asn His Gly
1105                1110                1115               1120 
Ile Asn Gln Asn Val Ser Gln Ser Leu Cys Gln Glu Asp Asp Tyr Glu
                1125                1130                1135    
Asp Asp Lys Pro Thr Asn Tyr Ser Glu Arg Tyr Ser Glu Glu Glu Gln
            1140                1145                1150        
His Glu Glu Glu Glu Arg Pro Thr Asn Tyr Ser Ile Lys Tyr Asn Glu
        1155                1160                1165            
Glu Lys Arg His Val Asp Gln Pro Ile Asp Tyr Ser Leu Lys Tyr Ala
    1170                1175                1180                
Thr Asp Ile Pro Ser Ser Gln Lys Gln Ser Phe Ser Phe Ser Lys Ser
1185                1190                1195               1200 
Ser Ser Gly Gln Ser Ser Lys Thr Glu His Met Ser Ser Ser Ser Glu
                1205                1210                1215    
Asn Thr Ser Thr Pro Ser Ser Asn Ala Lys Arg Gln Asn Gln Leu His
            1220                1225                1230        
Pro Ser Ser Ala Gln Ser Arg Ser Gly Gln Pro Gln Lys Ala Ala Thr
        1235                1240                1245            
Cys Lys Val Ser Ser Ile Asn Gln Glu Thr Ile Gln Thr Tyr Cys Val
    1250                1255                1260                
Glu Asp Thr Pro Ile Cys Phe Ser Arg Cys Ser Ser Leu Ser Ser Leu
1265                1270                1275               1280 
Ser Ser Ala Glu Asp Glu Ile Gly Cys Asn Gln Thr Thr Gln Glu Ala
                1285                1290                1295    
Asp Ser Ala Asn Thr Leu Gln Ile Ala Glu Ile Lys Glu Lys Ile Gly
            1300                1305                1310        
Thr Arg Ser Ala Glu Asp Pro Val Ser Glu Val Pro Ala Val Ser Gln
        1315                1320                1325            
His Pro Arg Thr Lys Ser Ser Arg Leu Gln Gly Ser Ser Leu Ser Ser
    1330                1335                1340                
Glu Ser Ala Arg His Lys Ala Val Glu Phe Ser Ser Gly Ala Lys Ser
1345                1350                1355               1360 
Pro Ser Lys Ser Gly Ala Gln Thr Pro Lys Ser Pro Pro Glu His Tyr
                1365                1370                1375    
Val Gln Glu Thr Pro Leu Met Phe Ser Arg Cys Thr Ser Val Ser Ser
            1380                1385                1390        
Leu Asp Ser Phe Glu Ser Arg Ser Ile Ala Ser Ser Val Gln Ser Glu
        1395                1400                1405            
Pro Cys Ser Gly Met Val Ser Gly Ile Ile Ser Pro Ser Asp Leu Pro
    1410                1415                1420                
Asp Ser Pro Gly Gln Thr Met Pro Pro Ser Arg Ser Lys Thr Pro Pro
1425                1430                1435               1440 
Pro Pro Pro Gln Thr Ala Gln Thr Lys Arg Glu Val Pro Lys Asn Lys
                1445                1450                1455    
Ala Pro Thr Ala Glu Lys Arg Glu Ser Gly Pro Lys Gln Ala Ala Val
            1460                1465                1470        
Asn Ala Ala Val Gln Arg Val Gln Val Leu Pro Asp Ala Asp Thr Leu
        1475                1480                1485            
Leu His Phe Ala Thr Glu Ser Thr Pro Asp Gly Phe Ser Cys Ser Ser
    1490                1495                1500                
Ser Leu Ser Ala Leu Ser Leu Asp Glu Pro Phe Ile Gln Lys Asp Val
1505                1510                1515               1520 
Glu Leu Arg Ile Met Pro Pro Val Gln Glu Asn Asp Asn Gly Asn Glu
                1525                1530                1535    
Thr Glu Ser Glu Gln Pro Lys Glu Ser Asn Glu Asn Gln Glu Lys Glu
            1540                1545                1550        
Ala Glu Lys Thr Ile Asp Ser Glu Lys Asp Leu Leu Asp Asp Ser Asp
        1555                1560                1565            
Asp Asp Asp Ile Glu Ile Leu Glu Glu Cys Ile Ile Ser Ala Met Pro
    1570                1575                1580                
Thr Lys Ser Ser Arg Lys Ala Lys Lys Pro Ala Gln Thr Ala Ser Lys
1585                1590                1595               1600 
Leu Pro Pro Pro Val Ala Arg Lys Pro Ser Gln Leu Pro Val Tyr Lys
                1605                1610                1615    
Leu Leu Pro Ser Gln Asn Arg Leu Gln Pro Gln Lys His Val Ser Phe
            1620                1625                1630        
Thr Pro Gly Asp Asp Met Pro Arg Val Tyr Cys Val Glu Gly Thr Pro
        1635                1640                1645            
Ile Asn Phe Ser Thr Ala Thr Ser Leu Ser Asp Leu Thr Ile Glu Ser
    1650                1655                1660                
Pro Pro Asn Glu Leu Ala Ala Gly Glu Gly Val Arg Gly Gly Ala Gln
1665                1670                1675               1680 
Ser Gly Glu Phe Glu Lys Arg Asp Thr Ile Pro Thr Glu Gly Arg Ser
                1685                1690                1695    
Thr Asp Glu Ala Gln Gly Gly Lys Thr Ser Ser Val Thr Ile Pro Glu
            1700                1705                1710        
Leu Asp Asp Asn Lys Ala Glu Glu Gly Asp Ile Leu Ala Glu Cys Ile
        1715                1720                1725            
Asn Ser Ala Met Pro Lys Gly Lys Ser His Lys Pro Phe Arg Val Lys
    1730                1735                1740                
Lys Ile Met Asp Gln Val Gln Gln Ala Ser Ala Ser Ser Ser Ala Pro
1745                1750                1755               1760 
Asn Lys Asn Gln Leu Asp Gly Lys Lys Lys Lys Pro Thr Ser Pro Val
                1765                1770                1775    
Lys Pro Ile Pro Gln Asn Thr Glu Tyr Arg Thr Arg Val Arg Lys Asn
            1780                1785                1790        
Ala Asp Ser Lys Asn Asn Leu Asn Ala Glu Arg Val Phe Ser Asp Asn
        1795                1800                1805            
Lys Asp Ser Lys Lys Gln Asn Leu Lys Asn Asn Ser Lys Val Phe Asn
    1810                1815                1820                
Asp Lys Leu Pro Asn Asn Glu Asp Arg Val Arg Gly Ser Phe Ala Phe
1825                1830                1835               1840 
Asp Ser Pro His His Tyr Thr Pro Ile Glu Gly Thr Pro Tyr Cys Phe
                1845                1850                1855    
Ser Arg Asn Asp Ser Leu Ser Ser Leu Asp Phe Asp Asp Asp Asp Val
            1860                1865                1870        
Asp Leu Ser Arg Glu Lys Ala Glu Leu Arg Lys Ala Lys Glu Asn Lys
        1875                1880                1885            
Glu Ser Glu Ala Lys Val Thr Ser His Thr Glu Leu Thr Ser Asn Gln
    1890                1895                1900                
Gln Ser Ala Asn Lys Thr Gln Ala Ile Ala Lys Gln Pro Ile Asn Arg
1905                1910                1915               1920 
Gly Gln Pro Lys Pro Ile Leu Gln Lys Gln Ser Thr Phe Pro Gln Ser
                1925                1930                1935    
Ser Lys Asp Ile Pro Asp Arg Gly Ala Ala Thr Asp Glu Lys Leu Gln
            1940                1945                1950        
Asn Phe Ala Ile Glu Asn Thr Pro Val Cys Phe Ser His Asn Ser Ser
        1955                1960                1965            
Leu Ser Ser Leu Ser Asp Ile Asp Gln Glu Asn Asn Asn Lys Glu Asn
    1970                1975                1980                
Glu Pro Ile Lys Glu Thr Glu Pro Pro Asp Ser Gln Gly Glu Pro Ser
1985                1990                1995               2000 
Lys Pro Gln Ala Ser Gly Tyr Ala Pro Lys Ser Phe His Val Glu Asp
                2005                2010                2015    
Thr Pro Val Cys Phe Ser Arg Asn Ser Ser Leu Ser Ser Leu Ser Ile
            2020                2025                2030        
Asp Ser Glu Asp Asp Leu Leu Gln Glu Cys Ile Ser Ser Ala Met Pro
        2035                2040                2045            
Lys Lys Lys Lys Pro Ser Arg Leu Lys Gly Asp Asn Glu Lys His Ser
    2050                2055                2060                
Pro Arg Asn Met Gly Gly Ile Leu Gly Glu Asp Leu Thr Leu Asp Leu
2065                2070                2075               2080 
Lys Asp Ile Gln Arg Pro Asp Ser Glu His Gly Leu Ser Pro Asp Ser
                2085                2090                2095    
Glu Asn Phe Asp Trp Lys Ala Ile Gln Glu Gly Ala Asn Ser Ile Val
            2100                2105                2110        
Ser Ser Leu His Gln Ala Ala Ala Ala Ala Cys Leu Ser Arg Gln Ala
        2115                2120                2125            
Ser Ser Asp Ser Asp Ser Ile Leu Ser Leu Lys Ser Gly Ile Ser Leu
    2130                2135                2140                
Gly Ser Pro Phe His Leu Thr Pro Asp Gln Glu Glu Lys Pro Phe Thr
2145                2150                2155               2160 
Ser Asn Lys Gly Pro Arg Ile Leu Lys Pro Gly Glu Lys Ser Thr Leu
                2165                2170                2175    
Glu Thr Lys Lys Ile Glu Ser Glu Ser Lys Gly Ile Lys Gly Gly Lys
            2180                2185                2190        
Lys Val Tyr Lys Ser Leu Ile Thr Gly Lys Val Arg Ser Asn Ser Glu
        2195                2200                2205            
Ile Ser Gly Gln Met Lys Gln Pro Leu Gln Ala Asn Met Pro Ser Ile
    2210                2215                2220                
Ser Arg Gly Arg Thr Met Ile His Ile Pro Gly Val Arg Asn Ser Ser
2225                2230                2235               2240 
Ser Ser Thr Ser Pro Val Ser Lys Lys Gly Pro Pro Leu Lys Thr Pro
                2245                2250                2255    
Ala Ser Lys Ser Pro Ser Glu Gly Gln Thr Ala Thr Thr Ser Pro Arg
            2260                2265                2270        
Gly Ala Lys Pro Ser Val Lys Ser Glu Leu Ser Pro Val Ala Arg Gln
        2275                2280                2285            
Thr Ser Gln Ile Gly Gly Ser Ser Lys Ala Pro Ser Arg Ser Gly Ser
    2290                2295                2300                
Arg Asp Ser Thr Pro Ser Arg Pro Ala Gln Gln Pro Leu Ser Arg Pro
2305                2310                2315               2320 
Ile Gln Ser Pro Gly Arg Asn Ser Ile Ser Pro Gly Arg Asn Gly Ile
                2325                2330                2335    
Ser Pro Pro Asn Lys Leu Ser Gln Leu Pro Arg Thr Ser Ser Pro Ser
            2340                2345                2350        
Thr Ala Ser Thr Lys Ser Ser Gly Ser Gly Lys Met Ser Tyr Thr Ser
        2355                2360                2365            
Pro Gly Arg Gln Met Ser Gln Gln Asn Leu Thr Lys Gln Thr Gly Leu
    2370                2375                2380                
Ser Lys Asn Ala Ser Ser Ile Pro Arg Ser Glu Ser Ala Ser Lys Gly
2385                2390                2395               2400 
Leu Asn Gln Met Asn Asn Gly Asn Gly Ala Asn Lys Lys Val Glu Leu
                2405                2410                2415    
Ser Arg Met Ser Ser Thr Lys Ser Ser Gly Ser Glu Ser Asp Arg Ser
            2420                2425                2430        
Glu Arg Pro Val Leu Val Arg Gln Ser Thr Phe Ile Lys Glu Ala Pro
        2435                2440                2445            
Ser Pro Thr Leu Arg Arg Lys Leu Glu Glu Ser Ala Ser Phe Glu Ser
    2450                2455                2460                
Leu Ser Pro Ser Ser Arg Pro Ala Ser Pro Thr Arg Ser Gln Ala Gln
2465                2470                2475               2480 
Thr Pro Val Leu Ser Pro Ser Leu Pro Asp Met Ser Leu Ser Thr His
                2485                2490                2495    
Ser Ser Val Gln Ala Gly Gly Trp Arg Lys Leu Pro Pro Asn Leu Ser
            2500                2505                2510        
Pro Thr Ile Glu Tyr Asn Asp Gly Arg Pro Ala Lys Arg His Asp Ile
        2515                2520                2525            
Ala Arg Ser His Ser Glu Ser Pro Ser Arg Leu Pro Ile Asn Arg Ser
    2530                2535                2540                
Gly Thr Trp Lys Arg Glu His Ser Lys His Ser Ser Ser Leu Pro Arg
2545                2550                2555               2560 
Val Ser Thr Trp Arg Arg Thr Gly Ser Ser Ser Ser Ile Leu Ser Ala
                2565                2570                2575    
Ser Ser Glu Ser Ser Glu Lys Ala Lys Ser Glu Asp Glu Lys His Val
            2580                2585                2590        
Asn Ser Ile Ser Gly Thr Lys Gln Ser Lys Glu Asn Gln Val Ser Ala
        2595                2600                2605            
Lys Gly Thr Trp Arg Lys Ile Lys Glu Asn Glu Phe Ser Pro Thr Asn
    2610                2615                2620                
Ser Thr Ser Gln Thr Val Ser Ser Gly Ala Thr Asn Gly Ala Glu Ser
2625                2630                2635               2640 
Lys Thr Leu Ile Tyr Gln Met Ala Pro Ala Val Ser Lys Thr Glu Asp
                2645                2650                2655    
Val Trp Val Arg Ile Glu Asp Cys Pro Ile Asn Asn Pro Arg Ser Gly
            2660                2665                2670        
Arg Ser Pro Thr Gly Asn Thr Pro Pro Val Ile Asp Ser Val Ser Glu
        2675                2680                2685            
Lys Ala Asn Pro Asn Ile Lys Asp Ser Lys Asp Asn Gln Ala Lys Gln
    2690                2695                2700                
Asn Val Gly Asn Gly Ser Val Pro Met Arg Thr Val Gly Leu Glu Asn
2705                2710                2715               2720 
Arg Leu Asn Ser Phe Ile Gln Val Asp Ala Pro Asp Gln Lys Gly Thr
                2725                2730                2735    
Glu Ile Lys Pro Gly Gln Asn Asn Pro Val Pro Val Ser Glu Thr Asn
            2740                2745                2750        
Glu Ser Ser Ile Val Glu Arg Thr Pro Phe Ser Ser Ser Ser Ser Ser
        2755                2760                2765            
Lys His Ser Ser Pro Ser Gly Thr Val Ala Ala Arg Val Thr Pro Phe
    2770                2775                2780                
Asn Tyr Asn Pro Ser Pro Arg Lys Ser Ser Ala Asp Ser Thr Ser Ala
2785                2790                2795               2800 
Arg Pro Ser Gln Ile Pro Thr Pro Val Asn Asn Asn Thr Lys Lys Arg
                2805                2810                2815    
Asp Ser Lys Thr Asp Ser Thr Glu Ser Ser Gly Thr Gln Ser Pro Lys
            2820                2825                2830        
Arg His Ser Gly Ser Tyr Leu Val Thr Ser Val
        2835                2840            

