               SEQUENCE LISTING

<110> Lek Pharmaceuticals d.d.

<120> Process for production of clavulanic acid

<130> L 227

<160> 16

<170> BiSSAP 1.0

<210> 1
<211> 12169
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..12169
<223> /mol_type="DNA"
      /note="Nucleic acid sequence comprising the gene pcbAB from the g
      enome of Streptomyces clavuligerus, primer binding sites and codi
      ng region"
      /organism="Artificial Sequence"

<220> 
<221> CDS
<222> 320..11578
<223> /transl_table=11
      /translation="MLLKDEWRNRIAVRDDDPGVRATRQRDIVVDGREYTALKDALRAADGVSAG
      ALALASLHSVMRAYGHGEQTVAAFVDATATAELKTAAVLPVIVDHIEHTRLTCAEAIRELDETLR
      RKDSYTRADEVLQRGLFDALLVLAEREVALSELPSAPLVMVVRDDAARGRLCWTMAYAGELFEDT
      TVAGVLEVVREVLGQYAGRPGDRVAEIELASREQRERLQRWNATDGDFPADQRLNDLVEAAVRRS
      PDREAVVFGTQRLTYREVDARANRFAHWLLGPGLGVRSQQLVGIFLDKSDLGVVATLGIWKAGAA
      YVPIDPAYPAERVRFAVGDTGLRGIVTNRHHAGRLREILGAEHADVTVVEIESVLDEQAAADTDG
      LLSVKPELALGVRDLAYLTYTSGTTGVPKGVPKYHDSVVNSITDLSERYDMRRPGTERVALFASY
      VFEPHLRQTLIALINGQTLVVVPEEVRLDPDRFPAYIEEHGVTYLNATGSVLQHFDLRRCTSLKR
      LLLVGEELTAAGLRQLRERFSGRIVNEYAFTEAAFVTAVKEFAPGVTERADRSIGRPVRNVKWYV
      LSQDLKRLPVGAIGELYIGGCGVAPGYLNRDDLTAERFLTNPYASEQDRARGMNARIYRTGDLAR
      MLPSGEVEFMGRSDFQLKLNGVRVEPGEIEAQATEYAGVRKCVVIAREGAGGGSDRHLVGYYLTE
      PGAGVTEAELLSFLERRLIRIMVPARMVRLESIPVNVNGKVDWRALPEVDLARPDTGGGAVGSTT
      TGGVRGELREIWSAVLGLPVSRIGDGDDFFRLGGQSISCILLIARIRQRLGVFVGVEDVFTLRTL
      GALADRLERDRGTAPADGTPQERRSAEGTADTTGTDGAEGADGGPVRLLANGLQQGLLYHALKRR
      NGDDAYVMQSVHHYRCAIRPELMREAWQHARRTYPALRLRFEWAEEALQIVENDDRSVDWRFTDL
      SGVADPAEQDARIRELQERDRTEPYDPAAGGLFRIYLIRRSEEFFSLLFSCHHIILDGWSLPVLH
      DDVHRTYLRLVDGEPVTADAGSTGTPGSTGNTGNTGKTDTAYIAAQRDWEAHRGDHVDYWTRQIE
      RIDERGDFGGLVREDIRYQVALSEYDHVKEHRTRRLALGAERTAALKAVCAEHSVTLHSVLQFVW
      HKVLYAVGGGNTTVVGTIVSGRNPHIDGIENSVGLFINTLPVIVDHDEQAALGTDAAIADIQSAV
      TAMAARSTVELGRLETGGMKRRLFDTLLVLENYPRLLSEDEERAHDELLRFEKAYDADKVDYPLA
      VVAREEGEELTVTLWYAGELFEDATIDTLLGVAETLFDQVAEDISRRVDRLELVSPAMVEQYGVW
      NRTTAPFPAGQTLHGVFERQAAAWPDETAVVFRDRRLTYRELNERANRLAHHLRSVAELRPNDLV
      GLVVDKNELMITAILAVWKTGAGYVPIDPGYPDDRVAFMLADTSAKLVITNQGRVARIGELTGGA
      LPVVDLDRLPDGNGADGDPVTDVTATDLAYAIYTSGTTGRPKAVLVEHRGVVNLQHSLAKLFGLD
      RSEGVEALLSFSNYVFDHFVEQMTDALLNGQKLVVLDDTMRTDAERLYRYINDEQVTYLSGTPSV
      LSLYDYSTTTSLTRIDAIGEDFTEPVFNKIRAMFPGTIINGYGPTEISITSHKRPYTVGERRSTK
      SIGHPVDNYTAYVLNKSMQRVPVGGMGELYIGGVGVTRGYLNRDELTADRFVDNPFQTAEERAEG
      RNARVYKTGDLVRWLPNGELECLGRTDLQVKIRGQRVELGEVEAALSSYPGVTRSLVIAREHRGA
      GLASAQKYLVGFYVGTDDLDEQDVRQWMRTKLPEAVVPSRVLRITDIPVTPSGKLDVTRLPETDF
      GPGDSGEYIAPSNDVETKLCGIWATVLGLAPERVGVTDDFFALGGDSLRAMVLAQAITTGFGRGL
      GVATVLQHTTLGAQAKHIRESAAHGDGEQDGPVAGRAAAGDGNPPVSLAQERLLFIDEFEGGTDA
      YNIPFVLEIATGDAASTRDAVTGALRALLGRHAALRTLLRTDEHGVRRQYPLPAAEAAARFEVPL
      HTVADRTALDERLVERSRTVFRLDEELPLVADLFTAGPADGRAYLSLVVHHSAFDGWSWSTFREE
      LAALLRGVPVTDLRQVHGSYADFSLWQRQYLSGGRLAELTGYWTGALAGYETIRLPLDRPRPARF
      DYRGREIDFDLDEGTARALRELARSARVSLYSVLLGAWALTLRVYTGQDDFVVGTPAANRGRPEF
      DRTVGFFANLLALRVRVDADAGLAEYIRAVGADVVAAQVHGELPFEQLVKELNPEKDPSRHPVLQ
      VNFTLQNVTDRAPVGGGAGAEPEFTEYKPDAGGFTATKFDLSATVTENAAGRLAGNLTYAAALFD
      DDTAEGFIATFRQVLAEFARLADAGEQARVAEVDPVGAAERAALAAGPAGALQAAAAEALPAPRT
      LHTVFEEQAAAWPDAVAVAHGATRLTYRELNERANQLAHYLRSVARIRPSDLIGLVVEKSELTVV
      AILAVWKAGAGYLPIDPGHPDDRVTFMLADTEARLVVTQRAHGERLRRLAGDALPVVEIDALPQG
      YRSTDDPVTDTTPADLAYAIYTSGTTGRPKAVLVPHRAVDSFRATLAGRYFGPPDTGRQGVLFLA
      NYVFDFSVEQLALSVLGGHTLIVPPPSPAQDERFYEDANRAGLTYISGTPTQVQQFDLARLPGLR
      TVLVAGEAFHERHFEKIREGWAGPILNAYGTTETAVYNTVRRFEPGDPYRNTLGLPLGNTRLYVL
      GDGLKPLPPGAVGELYVAGECVTDGYLNRPELTGERFLPNPFDTGEEGREGRHPVLYRSGDLVRL
      TRGGELQYLGRNDAQLKIRGLRIEPGEVEAVLATAPGVRECAVAAVADDRSPGNTRLVGYYVAAT
      GTETDTDTGTGDAGGADEDAIFAVLRARLMPGMVPSLLIRMDGPLPMTINGKLDTKALPKAALPE
      RRADRTAPRNRTEARLCQLWGDRLPGGTVGIDDDFFRSGGDSISALHLASQVQREIGRRVGVKDI
      FDHPTVRHFAERVLAAPDRGRDPGEGGEAPEQGRLDGDCPLLPIQEWFFAKPLADRNWWNHNFAV
      TAPELDVARLGQALARLVEHHDAFSLRYRSEGGGDGADERFVQRYDAAVPEVVLHELDVRGLSPE
      EISERLARWQSGFDLERGPIHCAAYLHGFADGSARVWFALHHLVVDTVSWHILAQDLEILYHGGA
      LEEKTSSYRQWARALAAYPADEAERRLWAEAVASLAATAQALPVPAPGAATLREEFALDAERTTA
      LLTECHWAYDTTINDLLLTAVGGALRAVTGLAVNHVTVEGHGRERFDGAPDVRDTVGWFTTMHPL
      AVEAHPQDVGRGITATKEASRRVPHHGIGYGALFGRYGGERAPLPPVSFNYLGRVSDAGEQTDGP
      SAGWRLDSAMSGSNISGRNRGADQFSVDVTMRCTGGRLVTAVDSRLDEETTRRFTDELRSWLERL
      VAHTSAVSGENGGRARAAERAGAGTEFDPYILVDGDRAERTLFVFPPGEGGAESYLSNLAQRLPG
      HRLVLFNNVHLHRPMESFEALADFYLPLLREIQPSGPYHLLGWSFGGVLSVEVSLRLARAGERIE
      ELFLIDPYFDVRASSAAIGLPETEDILDPINYHWAPAREDLERLRANTGDVVLFRADEPNEIVRD
      EEQRRLFDFYQRSSFNGLDALLPAESIEVHRLHGETHHSWVRNDRLVADICARVSASSPDAR"

<220> 
<221> primer_bind
<222> 1..18

<220> 
<221> primer_bind
<222> 12149..12169

<220> 
<221> primer_bind
<222> 1011..1028

<220> 
<221> primer_bind
<222> 11139..11156

<400> 1
cgctgacgat cgccgagcac gagatcgacc aggcccttca ggcgctggcg agcagtgtca       60

cggcggtcgc cgagagcgtc tgacgcccgg ccggccgggt gccccagcgg ggcccggccg      120

gccgcaccgc ggaacggaac acccctggcg cgtcgcccgg tgacacgctc tccgggcggc      180

tcaaccgcgc cacccccacg gcacgttcgc cttcacccgc acggagagcc cacgaatgat      240

gtcagcacgg tacccgagga ccgcagcgga gtggaccact cgcattcaag gagtgtcgag      300

cgagcgttgc gatcttgaaa tgctgctgaa ggacgagtgg cgcaacagga tcgcggtacg      360

ggacgacgac cccggtgtcc gtgcgacgag gcagcgggac atcgtcgtcg acgggcggga      420

gtacaccgct ctgaaggacg cgctgcgcgc cgccgacggg gtctcggcgg gcgcgctcgc      480

gctggcctcc ctgcacagcg tgatgcgcgc gtacggccat ggcgagcaga cggtggcggc      540

gttcgtcgac gcgacggcga cggcggagct gaagacggcc gccgtgctgc cggtgatcgt      600

cgaccatatc gagcacaccc ggctgacctg cgccgaggcg atccgggagc tggacgagac      660

gctgcgccgc aaggactcct acacccgtgc ggacgaggtg ctccagcggg ggctcttcga      720

tgccctgctg gtgctcgccg agcgcgaggt ggccctgtcc gagctgccgt cggccccgct      780

ggtcatggtc gtccgggacg acgcggcccg gggccggctg tgctggacga tggcgtacgc      840

gggcgagctg ttcgaggaca cgacggtcgc cggtgtgctg gaggtcgtcc gggaggtgct      900

cgggcagtac gccgggcggc cgggcgaccg ggtcgccgag atcgagctgg cctcgcggga      960

gcagcgcgag cggcttcagc ggtggaacgc gaccgatggc gacttcccgg cggaccagcg     1020

cctcaacgac ctggtcgagg cggccgtgcg gcggtcgccg gaccgtgagg cggtcgtctt     1080

cgggacacag cggctgacct atcgggaggt cgacgcgcgg gcgaaccggt tcgcgcactg     1140

gctgctcggt ccgggtctcg gggtccgttc gcagcagctc gtcgggatct ttctggacaa     1200

gagcgatctc ggggtggtcg ccacgctcgg catctggaag gcgggcgcgg cctatgtgcc     1260

gatcgacccg gcctatccgg cggagcgggt gcggttcgcg gtcggtgaca ccgggctgcg     1320

gggcatcgtc accaaccggc accacgcggg gcggctgcgg gagatcctgg gcgcggagca     1380

cgcggatgtg acggtcgtcg agatcgagtc cgtgctcgac gagcaggccg ccgccgacac     1440

cgacggcctg ctgagtgtga agcccgagct ggcgctgggg gtacgggatc tggcctatct     1500

cacctacacc tccggcacca ccggtgtgcc gaagggggtg cccaagtacc acgacagtgt     1560

cgtgaacagc atcacggacc tgtcggagcg gtacgacatg cggcggccgg gcacggagcg     1620

ggtcgcgctc ttcgcctcgt acgtcttcga gccgcatctg cggcagacgc tgatcgcgct     1680

catcaacggg cagacgctgg tcgtcgtccc cgaggaggtc cggctcgacc cggaccgctt     1740

ccccgcgtac atcgaggagc acggcgtcac gtacctcaac gcgacgggtt cggtgctgca     1800

acacttcgat ctgcgccgat gtaccagcct gaaacggctg ttgctggtcg gcgaggagct     1860

gacggcggcc gggctgcgcc agctccgcga gcggttctcc gggcggatcg tcaacgagta     1920

cgccttcacc gaggcggcgt tcgtcaccgc cgtgaaggag ttcgcgccgg gcgtcaccga     1980

gcgcgcggac cgcagcatcg gccgaccggt gcggaatgtg aagtggtatg tcctcagcca     2040

ggatctgaag cggttgccgg tcggggcgat cggcgagctg tacatcggcg gctgcggggt     2100

ggcgccgggc tatctgaacc gcgacgacct gacggccgag cggttcctga ccaatccgta     2160

cgcctcggag caggaccggg cgcgcgggat gaacgcccgg atctaccgga ccggtgacct     2220

ggcgcggatg ctgccgtccg gcgaggtcga gttcatgggc cgcagcgact tccagctcaa     2280

gctgaacggt gtccgggtgg agccgggcga gatcgaggcg caggccaccg agtatgcggg     2340

ggtccgcaag tgcgtggtca tcgcccgtga gggggcgggc ggcggcagcg accgccatct     2400

ggtcggctac tacctgacgg agcccggggc cggggtgacc gaggcggagc tgctgtcctt     2460

cctggagcgg cggctcatcc ggatcatggt cccggcgcgg atggtccggc tggagagcat     2520

ccccgtcaat gtcaacggca aggtcgactg gcgggcgctg cccgaggtgg acctcgcccg     2580

cccggacacg ggcggcggcg cggtgggctc caccacgacc gggggtgtcc ggggtgagct     2640

gcgcgagatc tggagcgcgg tcctcggcct tccggtgtcc cgtatcggcg acggcgacga     2700

cttcttccgg ctcggcggcc agagcatctc ctgcattctg ctcatcgccc ggatacggca     2760

gcggctgggc gtcttcgtcg gggtcgagga cgtcttcacg ctgaggacgc tgggcgcgct     2820

ggcggaccgg ctggagcgcg accggggcac ggcgcccgcg gacggcacgc cgcaggagcg     2880

gcggtccgcc gagggcacag cggacacgac gggcacggac ggtgcggagg gcgcggacgg     2940

cgggcccgtg cggctgctcg cgaacggtct ccagcagggg ctgctctacc acgccctgaa     3000

gcgccgcaac ggcgacgacg cctatgtgat gcagtcggtg caccactacc gctgcgccat     3060

ccgccccgag ctgatgcgcg aggcgtggca gcacgcgcgg cgcacgtacc ccgcgctgcg     3120

gctgcgtttc gagtgggccg aggaggccct ccagatcgtc gagaacgacg accgttccgt     3180

ggactggcgg ttcaccgatc tgagcggggt ggccgacccg gcggagcagg acgcccggat     3240

ccgggagctc caggagcggg accggaccga gccctacgac ccggcggcgg gcgggctgtt     3300

ccggatctat ctgatccgcc ggagcgaaga gttcttctcg ctgctgttca gctgccacca     3360

catcatcctg gacggctgga gcctgccggt cctccacgac gacgtgcacc ggacctatct     3420

gcggctggtg gacggcgagc cggtcacggc ggacgcgggg agcaccggta cccccgggag     3480

caccgggaac accgggaaca ccgggaagac ggacaccgcg tacatcgcgg cgcagcggga     3540

ctgggaggcg caccgcggcg accacgtcga ctactggacc cgtcagatcg agcggatcga     3600

cgagcggggc gacttcggcg ggctggtccg ggaggacatc cgctaccagg tggcgctgag     3660

cgagtacgac cacgtcaagg agcaccggac ccggcggctc gccctcggtg ccgagcggac     3720

cgcggcgctg aaggcggtct gcgcggagca ctccgtgacc ctgcactcgg tgctccagtt     3780

cgtgtggcac aaggtgctgt acgccgtcgg cggcgggaac accacggtgg tcggcacgat     3840

cgtgtccggg cgcaatccgc acatcgacgg gatcgagaac tccgtcggtc tgttcatcaa     3900

cacgctgccc gtgatcgtcg accacgacga gcaggcggcg ctgggcacgg acgcggccat     3960

cgcggacatc cagtccgccg tgaccgccat ggccgcccgg agcacggtgg agctgggccg     4020

gctggagacc ggcgggatga agcgccgcct cttcgacacc ctgctggtcc tggagaacta     4080

tccgcggctg ctctccgagg acgaggagcg cgcccacgac gagttgctgc gcttcgagaa     4140

ggcgtacgac gccgacaagg tcgactatcc gctggccgtg gtcgcccgcg aggagggtga     4200

ggagctgacc gtcaccctct ggtacgcggg tgagctgttc gaggacgcca cgatcgacac     4260

cctgctcggg gtggcggaga ccctgttcga ccaggtggcc gaggacatct cgcgccgggt     4320

ggaccggctg gagctggtct cgcccgcgat ggtcgagcag tacggggtgt ggaaccggac     4380

cacggccccg ttcccggccg ggcagaccct gcacggggtc ttcgagcggc aggccgccgc     4440

ctggccggac gagaccgcgg tggtcttccg cgaccggcgg ctgacctacc gggagctgaa     4500

cgagcgcgcc aaccggctgg cgcaccatct gcgctcggtc gcggagctgc gcccgaacga     4560

cctggtcggc ctggtcgtcg acaagaacga gctgatgatc accgcgatcc tggcggtgtg     4620

gaagacgggc gcgggctatg tcccgatcga cccgggctac cccgacgacc gggtggcgtt     4680

catgctggcg gacaccagcg ccaagctggt gatcaccaac caggggcggg tggcgcggat     4740

cggggagctg accggtggcg cgctgccggt ggtggatctc gaccggctgc ccgacggcaa     4800

cggcgcggac ggcgacccgg tcaccgatgt caccgccacg gatctcgcgt acgcgatcta     4860

cacctccggc accaccggca ggcccaaggc ggtgctggtc gagcaccggg gtgtggtgaa     4920

cctccagcac tcgctggcga agctgttcgg cctggaccgg agcgagggcg tcgaggcgct     4980

gctgtcgttc tcgaactacg tcttcgacca cttcgtggag cagatgacgg acgccctgct     5040

caacgggcag aagctggtcg tcctcgacga caccatgcgc acggacgccg agcggctgta     5100

ccggtacatc aacgacgagc aggtcaccta tctctccggc acgccgtcgg tgctctcgct     5160

ctacgactac tcgacgacga cctcgctgac ccggatcgac gcgatcggcg aggacttcac     5220

cgagccggtc ttcaacaaga tccgcgccat gttcccgggg acgatcatca acgggtacgg     5280

gccgacggag atctcgatca ccagccacaa gcggccctac acggtcggcg agcggcggtc     5340

gacgaagagc atcggccacc cggtggacaa ctacacggcc tatgtcctga acaagtcgat     5400

gcagcgggtg ccggtcggcg gcatgggcga gctgtacatc ggcggtgtcg gcgtcacccg     5460

cggctatctg aaccgcgacg agctgacggc ggaccgcttc gtcgacaacc ccttccagac     5520

cgccgaggag cgggccgagg ggcgcaacgc gcgcgtctac aagaccggtg acctggtgcg     5580

ctggctgccc aacggcgagc tggagtgcct gggccgcacc gacctccagg tcaagatccg     5640

gggacagcgg gtcgagctgg gcgaggtcga ggccgcgctc tcctcgtacc cgggcgtcac     5700

ccgttccctg gtcatcgcgc gggagcaccg gggcgcgggg ctcgcgtcgg cgcagaagta     5760

cctcgtgggc ttctatgtcg gcacggacga tctggacgag caggacgtca ggcagtggat     5820

gcggacgaag ctgcccgagg cggtcgtccc ctcccgggtg ctgcggatca ccgacatccc     5880

ggtgacgccg agcggcaagc tggacgtcac acggctcccg gagaccgact tcggcccggg     5940

tgacagcggc gagtacatcg cgccgtcgaa cgatgtcgag accaagctgt gcggcatctg     6000

ggccacggtg ctcggtctcg ccccggagcg ggtcggcgtc accgacgact tcttcgccct     6060

cggcggcgac agcctccggg cgatggtgct ggcgcaggcc atcaccaccg gcttcggccg     6120

gggtctcggg gtcgcgaccg tgctccagca cacgaccctc ggggcgcagg cgaagcacat     6180

ccgcgagagc gccgcgcacg gcgacgggga gcaggacggg ccggtcgcgg gccgggccgc     6240

ggcgggcgac ggaaacccgc cggtgtcgct cgcgcaggaa cgtctgctgt tcatcgacga     6300

gttcgagggc ggcaccgacg cctacaacat ccccttcgtc ctggagatcg cgaccgggga     6360

cgccgcctcg acccgggacg cggtcaccgg ggcgctgcgc gccctgctgg ggcggcacgc     6420

ggcgctgcgc accctgctgc ggaccgacga gcacggcgtc cggcggcagt acccgctgcc     6480

cgccgccgag gccgcggccc ggttcgaggt cccgctgcac acggtcgcgg accgcacggc     6540

cctggacgag cggctggtgg agcggtcccg cacggtcttc cggctggacg aggagctgcc     6600

gctcgtggcc gacctcttca cggccggtcc ggcggacggc cgcgcgtatc tgagtctggt     6660

cgtccaccac agcgccttcg acggctggtc gtggagcacc ttccgggagg agctggcggc     6720

cctgctgcgc ggtgtccccg tgacggatct gcggcaggtc cacggcagct acgccgactt     6780

ctcgctgtgg cagcggcagt atctgtccgg gggcaggctg gcggagctga ccgggtactg     6840

gacgggggcg ctggccgggt acgagacgat ccggctgccg ctggaccgcc cgcgtccggc     6900

gcgcttcgac taccggggcc gggagatcga cttcgacctc gacgagggga cggcgcgggc     6960

gctgcgcgag ctggcgcggt ccgcgcgggt gagcctgtac agcgtgctgc tcggcgcgtg     7020

ggcgctcacc ctgcgcgtct acaccggcca ggacgacttc gtcgtgggca cgcccgccgc     7080

gaaccggggg cgcccggagt tcgaccggac cgtcggcttc ttcgcgaacc tgctggcgct     7140

gcgggtccgg gtcgacgcgg acgccggtct cgcggagtac atccgcgcgg tcggcgcgga     7200

cgtggtcgcg gcccaggtcc acggcgagct gccgttcgag cagctcgtga aggagctgaa     7260

cccggagaag gacccgagcc ggcaccccgt gctccaggtc aacttcaccc tccagaacgt     7320

caccgaccgc gctcccgtcg gcggcggggc cggggcggag ccggagttca ccgagtacaa     7380

gccggacgcc gggggcttca cggccaccaa gttcgatctg tcggcgacgg tcaccgagaa     7440

cgccgcgggg cggctcgcgg gcaacctcac ctacgccgcc gcgctcttcg acgacgacac     7500

cgccgaaggg ttcatcgcca ccttccggca ggtcctcgcg gagttcgcgc ggctcgcgga     7560

cgccggggag caggccaggg tcgcggaggt ggacccggtc ggcgcggcgg agcgcgcggc     7620

cctcgcggcc ggtcccgccg gggccctcca ggccgcggcc gccgaggcgc tgcccgcccc     7680

ccggaccctg cacacggtct tcgaggagca ggccgccgcc tggccggacg ccgtcgcggt     7740

cgcccacggc gcgacccggc tcacctaccg ggagctgaac gagcgcgcca accagctcgc     7800

gcactatctg cgctccgtgg cgcggatccg tccgagcgat ctgatcggcc tggtcgtcga     7860

gaagagcgag ctgaccgtcg tcgcgatcct cgcggtgtgg aaggcgggcg cgggctatct     7920

gccgatcgac ccgggccacc ccgacgaccg ggtgaccttc atgctggcgg acaccgaggc     7980

ccggctggtg gtcacccagc gggcccacgg ggagcggctg cgccgcctcg cgggcgacgc     8040

gctgccggtg gtggagatcg acgcgctgcc gcagggctac cgctcgaccg acgacccggt     8100

cacggacacc accccggcgg acctcgcgta cgcgatctac acctcgggca ccaccggccg     8160

ccccaaggcg gtgctggttc cgcaccgcgc ggtggacagc ttccgcgcga cgctggccgg     8220

acggtacttc ggcccgcccg acaccggccg ccagggggtg ctgttcctcg ccaactatgt     8280

cttcgacttc tcggtggagc agctcgcgct gtccgtcctc ggcggtcaca ccctgatcgt     8340

cccgccgccg tcgcccgcgc aggacgagcg gttctacgag gacgcgaacc gcgccgggct     8400

gacgtacatc agcgggacgc ccacccaggt ccagcagttc gacctggcgc ggctgccggg     8460

gctgcgcaca gtgctggtcg ccggtgaggc gttccacgag cgccacttcg agaagatccg     8520

cgagggctgg gcggggccga tcctcaacgc gtacggcacc accgagacgg ccgtctacaa     8580

caccgtccgg cgcttcgagc cgggtgaccc ctaccgcaac accctgggtc tgccgctcgg     8640

gaacacccgg ctgtacgtcc tcggcgacgg gctgaagccg ctgccgccgg gcgcggtcgg     8700

cgagctgtat gtggccggtg agtgtgtgac ggacggctat ctcaaccggc cggagctgac     8760

cggtgagcgc ttcctgccga acccgttcga caccggggag gaggggcggg agggccgcca     8820

cccggtcctc taccgcagtg gcgacctggt ccggctgacc cgcggcggcg agctccagta     8880

cctgggccgc aacgacgccc agctcaagat ccgcgggctg cggatcgagc cgggcgaggt     8940

ggaggcggtc ctcgccaccg ctccgggggt ccgcgagtgc gcggtcgccg ccgtggccga     9000

cgaccgctcc ccggggaaca cccggctggt cggctactac gtcgccgcca ccggcacgga     9060

gacggacacg gacaccggca cgggcgacgc cgggggcgcc gacgaggacg cgatcttcgc     9120

ggtgctgcgg gcgcggctga tgccgggcat ggtgccctcg ctgctgatcc gcatggacgg     9180

cccgctgccg atgaccatca acggcaagct ggacaccaag gcgctgccga aggcggcgct     9240

gccggagcgg cgcgcggacc gcacggcccc gcgcaaccgg accgaggccc ggctgtgcca     9300

gctctggggc gaccggctcc ccggtggcac ggtcggcatc gacgacgact tcttccgctc     9360

gggcggcgac agcatcagcg ccctgcacct ggcgagccag gtgcagcggg agatcgggcg     9420

cagggtcggc gtcaaggaca tcttcgacca tccgaccgtc cggcacttcg ccgagcgggt     9480

gctggccgcc ccggaccggg ggcgggaccc cggcgagggc ggcgaggcgc ccgagcaggg     9540

ccggctggac ggtgactgtc cgctgctgcc catccaggag tggttcttcg ccaagccgct     9600

cgccgaccgg aactggtgga accacaactt cgccgtcacc gccccggagc tggacgtggc     9660

gaggctgggc caggcgctgg cgcggctggt cgagcaccat gacgcgttca gcctgcggta     9720

ccgctccgag ggcggcggcg acggcgcgga cgagcggttc gtccagcgct acgacgccgc     9780

cgtgcccgag gtcgtcctgc acgagctgga tgtgcgcggg ctctcccccg aggagatctc     9840

cgaacggctc gcccgctggc agagcggctt cgacctggag cgcggaccga tccactgcgc     9900

ggcctatctg cacggcttcg ccgatggctc ggcccgggtc tggttcgccc tgcaccacct     9960

ggtcgtcgac accgtgagct ggcacatcct cgcgcaggac ctggagatcc tgtaccacgg    10020

gggcgcgctg gaggagaaga cgagcagcta ccgccagtgg gcgcgggcgc tcgccgcgta    10080

cccggcggac gaggccgagc ggcggctgtg ggcggaggcc gtcgcgtccc tggcggccac    10140

cgcacaggcg ctgccggtcc cggcgccggg cgcggcgacg ctccgggagg agttcgcgct    10200

cgacgcggag cggaccacgg cgctgctgac cgagtgccac tgggcgtacg acaccaccat    10260

caacgatctg ctgctgacgg cggtcggggg cgcgctgcgg gccgtcaccg gcctggcggt    10320

caaccatgtc accgtggagg gccacggccg ggagcggttc gacggggcgc ccgacgtccg    10380

ggacacggtg ggctggttca cgaccatgca cccgctggcc gtggaggcgc acccgcagga    10440

cgtggggcgc ggcatcaccg ccacgaagga ggcttcccgg cgggtgccgc accacggcat    10500

cggatacggg gccctcttcg gccgctacgg cggggagcgg gcgccgctgc cgccggtgag    10560

cttcaactac ctcggccggg tctccgacgc cggggagcag acggacgggc cctccgcggg    10620

ctggcggctc gactcggcga tgtcggggag caacatctcc ggccgcaacc ggggcgccga    10680

ccagttcagt gtggacgtga ccatgcgatg taccggcggc cggctcgtca ccgcggtgga    10740

cagccgactg gacgaggaga ccacccggcg cttcacggac gagctgagga gctggctgga    10800

gcggctcgtc gcccacacct cggcggtgtc gggcgagaac ggcggccggg cgcgcgccgc    10860

cgagcgggcc ggggccggga cggagttcga cccgtacatc ctcgtcgacg gggaccgcgc    10920

cgagcgcacc ctcttcgtct tcccgcccgg tgagggcggc gccgagagct atctgagcaa    10980

tctcgcgcag cggctgcccg gccaccggct ggtgctcttc aacaatgtgc atctgcaccg    11040

gccgatggag tccttcgagg cgctggccga cttctatctc cccctcctcc gggagatcca    11100

gccgtccggc ccgtaccacc tgctgggctg gagcttcggc ggggtgctct cggtggaggt    11160

ctcgctccgg ctggcccggg cgggcgagcg gatcgaggag ctgttcctca tcgacccgta    11220

cttcgacgtc cgggcctcgt cggcggcgat cgggctgccg gagaccgagg acatcctcga    11280

tccgatcaac taccactggg cgcccgcccg ggaggatctg gagcggctgc gcgcgaacac    11340

cggcgatgtg gtgctgttcc gggcggacga gccgaacgag atcgtccggg acgaggagca    11400

gcgccggctg ttcgacttct accagcggtc ctccttcaac gggctggacg cgctgctgcc    11460

cgcggagtcc atcgaggtcc accggctgca cggtgagacc caccattcgt gggtacgaaa    11520

cgaccggctg gtcgccgaca tctgtgcgcg tgtctcggcg tcgtcgccgg atgcccggtg    11580

aacggccggg cgctgagtcc aaggagggtt tcatgccagt tctgatgccg tcggcccacg    11640

ttccgaccat cgacatctcg ccgctgttcg gaaccgacgc cgccgcgaag aagcgcgtcg    11700

ccgaggagat acacggggcc tgccgcggct cgggcttctt ctacgccacg aaccacggcg    11760

tggacgtcca gcagctccag gacgtggtga acgagttcca cggcgccatg accgaccagg    11820

agaagcacga cctggcgatc cacgcgtaca acccggacaa cccgcatgtg cgcaacggct    11880

actacaaggc ggtcccgggc aggaaggccg tcgagtcctt ctgttacctc aacccggact    11940

tcggcgagga ccacccgatg atcgccgcgg ggacgccgat gcacgaggtg aacctctggc    12000

ccgacgagga gcggcacccg cgcttccggc cgttctgcga gggctactac cggcagatgc    12060

tgaagctctc caccgtgctc atgcgggggc tggcgctggc gctcgggagg ccggagcact    12120

tcttcgacgc ggcgctcgcc gagcaggact ccctgtcgtc cgtctcgct                12169


<210> 2
<211> 3753
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..3753
<223> /mol_type="protein"
      /note="[CDS]:320..11578 from SEQ ID NO 1"
      /organism="Artificial Sequence"

<400> 2
Met Leu Leu Lys Asp Glu Trp Arg Asn Arg Ile Ala Val Arg Asp Asp 
1               5                   10                   15    
Asp Pro Gly Val Arg Ala Thr Arg Gln Arg Asp Ile Val Val Asp Gly 
            20                   25                  30        
Arg Glu Tyr Thr Ala Leu Lys Asp Ala Leu Arg Ala Ala Asp Gly Val 
        35                   40                  45            
Ser Ala Gly Ala Leu Ala Leu Ala Ser Leu His Ser Val Met Arg Ala 
    50                   55                  60                
Tyr Gly His Gly Glu Gln Thr Val Ala Ala Phe Val Asp Ala Thr Ala 
65                   70                  75                  80
Thr Ala Glu Leu Lys Thr Ala Ala Val Leu Pro Val Ile Val Asp His 
                85                   90                  95    
Ile Glu His Thr Arg Leu Thr Cys Ala Glu Ala Ile Arg Glu Leu Asp 
            100                  105                110        
Glu Thr Leu Arg Arg Lys Asp Ser Tyr Thr Arg Ala Asp Glu Val Leu 
        115                  120                125            
Gln Arg Gly Leu Phe Asp Ala Leu Leu Val Leu Ala Glu Arg Glu Val 
    130                  135                140                
Ala Leu Ser Glu Leu Pro Ser Ala Pro Leu Val Met Val Val Arg Asp 
145                  150                155                  160
Asp Ala Ala Arg Gly Arg Leu Cys Trp Thr Met Ala Tyr Ala Gly Glu 
                165                  170                175    
Leu Phe Glu Asp Thr Thr Val Ala Gly Val Leu Glu Val Val Arg Glu 
            180                  185                190        
Val Leu Gly Gln Tyr Ala Gly Arg Pro Gly Asp Arg Val Ala Glu Ile 
        195                  200                205            
Glu Leu Ala Ser Arg Glu Gln Arg Glu Arg Leu Gln Arg Trp Asn Ala 
    210                  215                220                
Thr Asp Gly Asp Phe Pro Ala Asp Gln Arg Leu Asn Asp Leu Val Glu 
225                  230                235                  240
Ala Ala Val Arg Arg Ser Pro Asp Arg Glu Ala Val Val Phe Gly Thr 
                245                  250                255    
Gln Arg Leu Thr Tyr Arg Glu Val Asp Ala Arg Ala Asn Arg Phe Ala 
            260                  265                270        
His Trp Leu Leu Gly Pro Gly Leu Gly Val Arg Ser Gln Gln Leu Val 
        275                  280                285            
Gly Ile Phe Leu Asp Lys Ser Asp Leu Gly Val Val Ala Thr Leu Gly 
    290                  295                300                
Ile Trp Lys Ala Gly Ala Ala Tyr Val Pro Ile Asp Pro Ala Tyr Pro 
305                  310                315                  320
Ala Glu Arg Val Arg Phe Ala Val Gly Asp Thr Gly Leu Arg Gly Ile 
                325                  330                335    
Val Thr Asn Arg His His Ala Gly Arg Leu Arg Glu Ile Leu Gly Ala 
            340                  345                350        
Glu His Ala Asp Val Thr Val Val Glu Ile Glu Ser Val Leu Asp Glu 
        355                  360                365            
Gln Ala Ala Ala Asp Thr Asp Gly Leu Leu Ser Val Lys Pro Glu Leu 
    370                  375                380                
Ala Leu Gly Val Arg Asp Leu Ala Tyr Leu Thr Tyr Thr Ser Gly Thr 
385                  390                395                  400
Thr Gly Val Pro Lys Gly Val Pro Lys Tyr His Asp Ser Val Val Asn 
                405                  410                415    
Ser Ile Thr Asp Leu Ser Glu Arg Tyr Asp Met Arg Arg Pro Gly Thr 
            420                  425                430        
Glu Arg Val Ala Leu Phe Ala Ser Tyr Val Phe Glu Pro His Leu Arg 
        435                  440                445            
Gln Thr Leu Ile Ala Leu Ile Asn Gly Gln Thr Leu Val Val Val Pro 
    450                  455                460                
Glu Glu Val Arg Leu Asp Pro Asp Arg Phe Pro Ala Tyr Ile Glu Glu 
465                  470                475                  480
His Gly Val Thr Tyr Leu Asn Ala Thr Gly Ser Val Leu Gln His Phe 
                485                  490                495    
Asp Leu Arg Arg Cys Thr Ser Leu Lys Arg Leu Leu Leu Val Gly Glu 
            500                  505                510        
Glu Leu Thr Ala Ala Gly Leu Arg Gln Leu Arg Glu Arg Phe Ser Gly 
        515                  520                525            
Arg Ile Val Asn Glu Tyr Ala Phe Thr Glu Ala Ala Phe Val Thr Ala 
    530                  535                540                
Val Lys Glu Phe Ala Pro Gly Val Thr Glu Arg Ala Asp Arg Ser Ile 
545                  550                555                  560
Gly Arg Pro Val Arg Asn Val Lys Trp Tyr Val Leu Ser Gln Asp Leu 
                565                  570                575    
Lys Arg Leu Pro Val Gly Ala Ile Gly Glu Leu Tyr Ile Gly Gly Cys 
            580                  585                590        
Gly Val Ala Pro Gly Tyr Leu Asn Arg Asp Asp Leu Thr Ala Glu Arg 
        595                  600                605            
Phe Leu Thr Asn Pro Tyr Ala Ser Glu Gln Asp Arg Ala Arg Gly Met 
    610                  615                620                
Asn Ala Arg Ile Tyr Arg Thr Gly Asp Leu Ala Arg Met Leu Pro Ser 
625                  630                635                  640
Gly Glu Val Glu Phe Met Gly Arg Ser Asp Phe Gln Leu Lys Leu Asn 
                645                  650                655    
Gly Val Arg Val Glu Pro Gly Glu Ile Glu Ala Gln Ala Thr Glu Tyr 
            660                  665                670        
Ala Gly Val Arg Lys Cys Val Val Ile Ala Arg Glu Gly Ala Gly Gly 
        675                  680                685            
Gly Ser Asp Arg His Leu Val Gly Tyr Tyr Leu Thr Glu Pro Gly Ala 
    690                  695                700                
Gly Val Thr Glu Ala Glu Leu Leu Ser Phe Leu Glu Arg Arg Leu Ile 
705                  710                715                  720
Arg Ile Met Val Pro Ala Arg Met Val Arg Leu Glu Ser Ile Pro Val 
                725                  730                735    
Asn Val Asn Gly Lys Val Asp Trp Arg Ala Leu Pro Glu Val Asp Leu 
            740                  745                750        
Ala Arg Pro Asp Thr Gly Gly Gly Ala Val Gly Ser Thr Thr Thr Gly 
        755                  760                765            
Gly Val Arg Gly Glu Leu Arg Glu Ile Trp Ser Ala Val Leu Gly Leu 
    770                  775                780                
Pro Val Ser Arg Ile Gly Asp Gly Asp Asp Phe Phe Arg Leu Gly Gly 
785                  790                795                  800
Gln Ser Ile Ser Cys Ile Leu Leu Ile Ala Arg Ile Arg Gln Arg Leu 
                805                  810                815    
Gly Val Phe Val Gly Val Glu Asp Val Phe Thr Leu Arg Thr Leu Gly 
            820                  825                830        
Ala Leu Ala Asp Arg Leu Glu Arg Asp Arg Gly Thr Ala Pro Ala Asp 
        835                  840                845            
Gly Thr Pro Gln Glu Arg Arg Ser Ala Glu Gly Thr Ala Asp Thr Thr 
    850                  855                860                
Gly Thr Asp Gly Ala Glu Gly Ala Asp Gly Gly Pro Val Arg Leu Leu 
865                  870                875                  880
Ala Asn Gly Leu Gln Gln Gly Leu Leu Tyr His Ala Leu Lys Arg Arg 
                885                  890                895    
Asn Gly Asp Asp Ala Tyr Val Met Gln Ser Val His His Tyr Arg Cys 
            900                  905                910        
Ala Ile Arg Pro Glu Leu Met Arg Glu Ala Trp Gln His Ala Arg Arg 
        915                  920                925            
Thr Tyr Pro Ala Leu Arg Leu Arg Phe Glu Trp Ala Glu Glu Ala Leu 
    930                  935                940                
Gln Ile Val Glu Asn Asp Asp Arg Ser Val Asp Trp Arg Phe Thr Asp 
945                  950                955                  960
Leu Ser Gly Val Ala Asp Pro Ala Glu Gln Asp Ala Arg Ile Arg Glu 
                965                  970                975    
Leu Gln Glu Arg Asp Arg Thr Glu Pro Tyr Asp Pro Ala Ala Gly Gly 
            980                  985                990        
Leu Phe Arg Ile Tyr Leu Ile Arg Arg Ser Glu Glu Phe Phe Ser Leu 
        995                  1000                1005            
Leu Phe Ser Cys His His Ile Ile Leu Asp Gly Trp Ser Leu Pro Val 
    1010                1015                1020                
Leu His Asp Asp Val His Arg Thr Tyr Leu Arg Leu Val Asp Gly Glu 
1025                1030                1035                1040
Pro Val Thr Ala Asp Ala Gly Ser Thr Gly Thr Pro Gly Ser Thr Gly 
                1045                1050                1055    
Asn Thr Gly Asn Thr Gly Lys Thr Asp Thr Ala Tyr Ile Ala Ala Gln 
            1060                1065                1070        
Arg Asp Trp Glu Ala His Arg Gly Asp His Val Asp Tyr Trp Thr Arg 
        1075                1080                1085            
Gln Ile Glu Arg Ile Asp Glu Arg Gly Asp Phe Gly Gly Leu Val Arg 
    1090                1095                1100                
Glu Asp Ile Arg Tyr Gln Val Ala Leu Ser Glu Tyr Asp His Val Lys 
1105                1110                1115                1120
Glu His Arg Thr Arg Arg Leu Ala Leu Gly Ala Glu Arg Thr Ala Ala 
                1125                1130                1135    
Leu Lys Ala Val Cys Ala Glu His Ser Val Thr Leu His Ser Val Leu 
            1140                1145                1150        
Gln Phe Val Trp His Lys Val Leu Tyr Ala Val Gly Gly Gly Asn Thr 
        1155                1160                1165            
Thr Val Val Gly Thr Ile Val Ser Gly Arg Asn Pro His Ile Asp Gly 
    1170                1175                1180                
Ile Glu Asn Ser Val Gly Leu Phe Ile Asn Thr Leu Pro Val Ile Val 
1185                1190                1195                1200
Asp His Asp Glu Gln Ala Ala Leu Gly Thr Asp Ala Ala Ile Ala Asp 
                1205                1210                1215    
Ile Gln Ser Ala Val Thr Ala Met Ala Ala Arg Ser Thr Val Glu Leu 
            1220                1225                1230        
Gly Arg Leu Glu Thr Gly Gly Met Lys Arg Arg Leu Phe Asp Thr Leu 
        1235                1240                1245            
Leu Val Leu Glu Asn Tyr Pro Arg Leu Leu Ser Glu Asp Glu Glu Arg 
    1250                1255                1260                
Ala His Asp Glu Leu Leu Arg Phe Glu Lys Ala Tyr Asp Ala Asp Lys 
1265                1270                1275                1280
Val Asp Tyr Pro Leu Ala Val Val Ala Arg Glu Glu Gly Glu Glu Leu 
                1285                1290                1295    
Thr Val Thr Leu Trp Tyr Ala Gly Glu Leu Phe Glu Asp Ala Thr Ile 
            1300                1305                1310        
Asp Thr Leu Leu Gly Val Ala Glu Thr Leu Phe Asp Gln Val Ala Glu 
        1315                1320                1325            
Asp Ile Ser Arg Arg Val Asp Arg Leu Glu Leu Val Ser Pro Ala Met 
    1330                1335                1340                
Val Glu Gln Tyr Gly Val Trp Asn Arg Thr Thr Ala Pro Phe Pro Ala 
1345                1350                1355                1360
Gly Gln Thr Leu His Gly Val Phe Glu Arg Gln Ala Ala Ala Trp Pro 
                1365                1370                1375    
Asp Glu Thr Ala Val Val Phe Arg Asp Arg Arg Leu Thr Tyr Arg Glu 
            1380                1385                1390        
Leu Asn Glu Arg Ala Asn Arg Leu Ala His His Leu Arg Ser Val Ala 
        1395                1400                1405            
Glu Leu Arg Pro Asn Asp Leu Val Gly Leu Val Val Asp Lys Asn Glu 
    1410                1415                1420                
Leu Met Ile Thr Ala Ile Leu Ala Val Trp Lys Thr Gly Ala Gly Tyr 
1425                1430                1435                1440
Val Pro Ile Asp Pro Gly Tyr Pro Asp Asp Arg Val Ala Phe Met Leu 
                1445                1450                1455    
Ala Asp Thr Ser Ala Lys Leu Val Ile Thr Asn Gln Gly Arg Val Ala 
            1460                1465                1470        
Arg Ile Gly Glu Leu Thr Gly Gly Ala Leu Pro Val Val Asp Leu Asp 
        1475                1480                1485            
Arg Leu Pro Asp Gly Asn Gly Ala Asp Gly Asp Pro Val Thr Asp Val 
    1490                1495                1500                
Thr Ala Thr Asp Leu Ala Tyr Ala Ile Tyr Thr Ser Gly Thr Thr Gly 
1505                1510                1515                1520
Arg Pro Lys Ala Val Leu Val Glu His Arg Gly Val Val Asn Leu Gln 
                1525                1530                1535    
His Ser Leu Ala Lys Leu Phe Gly Leu Asp Arg Ser Glu Gly Val Glu 
            1540                1545                1550        
Ala Leu Leu Ser Phe Ser Asn Tyr Val Phe Asp His Phe Val Glu Gln 
        1555                1560                1565            
Met Thr Asp Ala Leu Leu Asn Gly Gln Lys Leu Val Val Leu Asp Asp 
    1570                1575                1580                
Thr Met Arg Thr Asp Ala Glu Arg Leu Tyr Arg Tyr Ile Asn Asp Glu 
1585                1590                1595                1600
Gln Val Thr Tyr Leu Ser Gly Thr Pro Ser Val Leu Ser Leu Tyr Asp 
                1605                1610                1615    
Tyr Ser Thr Thr Thr Ser Leu Thr Arg Ile Asp Ala Ile Gly Glu Asp 
            1620                1625                1630        
Phe Thr Glu Pro Val Phe Asn Lys Ile Arg Ala Met Phe Pro Gly Thr 
        1635                1640                1645            
Ile Ile Asn Gly Tyr Gly Pro Thr Glu Ile Ser Ile Thr Ser His Lys 
    1650                1655                1660                
Arg Pro Tyr Thr Val Gly Glu Arg Arg Ser Thr Lys Ser Ile Gly His 
1665                1670                1675                1680
Pro Val Asp Asn Tyr Thr Ala Tyr Val Leu Asn Lys Ser Met Gln Arg 
                1685                1690                1695    
Val Pro Val Gly Gly Met Gly Glu Leu Tyr Ile Gly Gly Val Gly Val 
            1700                1705                1710        
Thr Arg Gly Tyr Leu Asn Arg Asp Glu Leu Thr Ala Asp Arg Phe Val 
        1715                1720                1725            
Asp Asn Pro Phe Gln Thr Ala Glu Glu Arg Ala Glu Gly Arg Asn Ala 
    1730                1735                1740                
Arg Val Tyr Lys Thr Gly Asp Leu Val Arg Trp Leu Pro Asn Gly Glu 
1745                1750                1755                1760
Leu Glu Cys Leu Gly Arg Thr Asp Leu Gln Val Lys Ile Arg Gly Gln 
                1765                1770                1775    
Arg Val Glu Leu Gly Glu Val Glu Ala Ala Leu Ser Ser Tyr Pro Gly 
            1780                1785                1790        
Val Thr Arg Ser Leu Val Ile Ala Arg Glu His Arg Gly Ala Gly Leu 
        1795                1800                1805            
Ala Ser Ala Gln Lys Tyr Leu Val Gly Phe Tyr Val Gly Thr Asp Asp 
    1810                1815                1820                
Leu Asp Glu Gln Asp Val Arg Gln Trp Met Arg Thr Lys Leu Pro Glu 
1825                1830                1835                1840
Ala Val Val Pro Ser Arg Val Leu Arg Ile Thr Asp Ile Pro Val Thr 
                1845                1850                1855    
Pro Ser Gly Lys Leu Asp Val Thr Arg Leu Pro Glu Thr Asp Phe Gly 
            1860                1865                1870        
Pro Gly Asp Ser Gly Glu Tyr Ile Ala Pro Ser Asn Asp Val Glu Thr 
        1875                1880                1885            
Lys Leu Cys Gly Ile Trp Ala Thr Val Leu Gly Leu Ala Pro Glu Arg 
    1890                1895                1900                
Val Gly Val Thr Asp Asp Phe Phe Ala Leu Gly Gly Asp Ser Leu Arg 
1905                1910                1915                1920
Ala Met Val Leu Ala Gln Ala Ile Thr Thr Gly Phe Gly Arg Gly Leu 
                1925                1930                1935    
Gly Val Ala Thr Val Leu Gln His Thr Thr Leu Gly Ala Gln Ala Lys 
            1940                1945                1950        
His Ile Arg Glu Ser Ala Ala His Gly Asp Gly Glu Gln Asp Gly Pro 
        1955                1960                1965            
Val Ala Gly Arg Ala Ala Ala Gly Asp Gly Asn Pro Pro Val Ser Leu 
    1970                1975                1980                
Ala Gln Glu Arg Leu Leu Phe Ile Asp Glu Phe Glu Gly Gly Thr Asp 
1985                1990                1995                2000
Ala Tyr Asn Ile Pro Phe Val Leu Glu Ile Ala Thr Gly Asp Ala Ala 
                2005                2010                2015    
Ser Thr Arg Asp Ala Val Thr Gly Ala Leu Arg Ala Leu Leu Gly Arg 
            2020                2025                2030        
His Ala Ala Leu Arg Thr Leu Leu Arg Thr Asp Glu His Gly Val Arg 
        2035                2040                2045            
Arg Gln Tyr Pro Leu Pro Ala Ala Glu Ala Ala Ala Arg Phe Glu Val 
    2050                2055                2060                
Pro Leu His Thr Val Ala Asp Arg Thr Ala Leu Asp Glu Arg Leu Val 
2065                2070                2075                2080
Glu Arg Ser Arg Thr Val Phe Arg Leu Asp Glu Glu Leu Pro Leu Val 
                2085                2090                2095    
Ala Asp Leu Phe Thr Ala Gly Pro Ala Asp Gly Arg Ala Tyr Leu Ser 
            2100                2105                2110        
Leu Val Val His His Ser Ala Phe Asp Gly Trp Ser Trp Ser Thr Phe 
        2115                2120                2125            
Arg Glu Glu Leu Ala Ala Leu Leu Arg Gly Val Pro Val Thr Asp Leu 
    2130                2135                2140                
Arg Gln Val His Gly Ser Tyr Ala Asp Phe Ser Leu Trp Gln Arg Gln 
2145                2150                2155                2160
Tyr Leu Ser Gly Gly Arg Leu Ala Glu Leu Thr Gly Tyr Trp Thr Gly 
                2165                2170                2175    
Ala Leu Ala Gly Tyr Glu Thr Ile Arg Leu Pro Leu Asp Arg Pro Arg 
            2180                2185                2190        
Pro Ala Arg Phe Asp Tyr Arg Gly Arg Glu Ile Asp Phe Asp Leu Asp 
        2195                2200                2205            
Glu Gly Thr Ala Arg Ala Leu Arg Glu Leu Ala Arg Ser Ala Arg Val 
    2210                2215                2220                
Ser Leu Tyr Ser Val Leu Leu Gly Ala Trp Ala Leu Thr Leu Arg Val 
2225                2230                2235                2240
Tyr Thr Gly Gln Asp Asp Phe Val Val Gly Thr Pro Ala Ala Asn Arg 
                2245                2250                2255    
Gly Arg Pro Glu Phe Asp Arg Thr Val Gly Phe Phe Ala Asn Leu Leu 
            2260                2265                2270        
Ala Leu Arg Val Arg Val Asp Ala Asp Ala Gly Leu Ala Glu Tyr Ile 
        2275                2280                2285            
Arg Ala Val Gly Ala Asp Val Val Ala Ala Gln Val His Gly Glu Leu 
    2290                2295                2300                
Pro Phe Glu Gln Leu Val Lys Glu Leu Asn Pro Glu Lys Asp Pro Ser 
2305                2310                2315                2320
Arg His Pro Val Leu Gln Val Asn Phe Thr Leu Gln Asn Val Thr Asp 
                2325                2330                2335    
Arg Ala Pro Val Gly Gly Gly Ala Gly Ala Glu Pro Glu Phe Thr Glu 
            2340                2345                2350        
Tyr Lys Pro Asp Ala Gly Gly Phe Thr Ala Thr Lys Phe Asp Leu Ser 
        2355                2360                2365            
Ala Thr Val Thr Glu Asn Ala Ala Gly Arg Leu Ala Gly Asn Leu Thr 
    2370                2375                2380                
Tyr Ala Ala Ala Leu Phe Asp Asp Asp Thr Ala Glu Gly Phe Ile Ala 
2385                2390                2395                2400
Thr Phe Arg Gln Val Leu Ala Glu Phe Ala Arg Leu Ala Asp Ala Gly 
                2405                2410                2415    
Glu Gln Ala Arg Val Ala Glu Val Asp Pro Val Gly Ala Ala Glu Arg 
            2420                2425                2430        
Ala Ala Leu Ala Ala Gly Pro Ala Gly Ala Leu Gln Ala Ala Ala Ala 
        2435                2440                2445            
Glu Ala Leu Pro Ala Pro Arg Thr Leu His Thr Val Phe Glu Glu Gln 
    2450                2455                2460                
Ala Ala Ala Trp Pro Asp Ala Val Ala Val Ala His Gly Ala Thr Arg 
2465                2470                2475                2480
Leu Thr Tyr Arg Glu Leu Asn Glu Arg Ala Asn Gln Leu Ala His Tyr 
                2485                2490                2495    
Leu Arg Ser Val Ala Arg Ile Arg Pro Ser Asp Leu Ile Gly Leu Val 
            2500                2505                2510        
Val Glu Lys Ser Glu Leu Thr Val Val Ala Ile Leu Ala Val Trp Lys 
        2515                2520                2525            
Ala Gly Ala Gly Tyr Leu Pro Ile Asp Pro Gly His Pro Asp Asp Arg 
    2530                2535                2540                
Val Thr Phe Met Leu Ala Asp Thr Glu Ala Arg Leu Val Val Thr Gln 
2545                2550                2555                2560
Arg Ala His Gly Glu Arg Leu Arg Arg Leu Ala Gly Asp Ala Leu Pro 
                2565                2570                2575    
Val Val Glu Ile Asp Ala Leu Pro Gln Gly Tyr Arg Ser Thr Asp Asp 
            2580                2585                2590        
Pro Val Thr Asp Thr Thr Pro Ala Asp Leu Ala Tyr Ala Ile Tyr Thr 
        2595                2600                2605            
Ser Gly Thr Thr Gly Arg Pro Lys Ala Val Leu Val Pro His Arg Ala 
    2610                2615                2620                
Val Asp Ser Phe Arg Ala Thr Leu Ala Gly Arg Tyr Phe Gly Pro Pro 
2625                2630                2635                2640
Asp Thr Gly Arg Gln Gly Val Leu Phe Leu Ala Asn Tyr Val Phe Asp 
                2645                2650                2655    
Phe Ser Val Glu Gln Leu Ala Leu Ser Val Leu Gly Gly His Thr Leu 
            2660                2665                2670        
Ile Val Pro Pro Pro Ser Pro Ala Gln Asp Glu Arg Phe Tyr Glu Asp 
        2675                2680                2685            
Ala Asn Arg Ala Gly Leu Thr Tyr Ile Ser Gly Thr Pro Thr Gln Val 
    2690                2695                2700                
Gln Gln Phe Asp Leu Ala Arg Leu Pro Gly Leu Arg Thr Val Leu Val 
2705                2710                2715                2720
Ala Gly Glu Ala Phe His Glu Arg His Phe Glu Lys Ile Arg Glu Gly 
                2725                2730                2735    
Trp Ala Gly Pro Ile Leu Asn Ala Tyr Gly Thr Thr Glu Thr Ala Val 
            2740                2745                2750        
Tyr Asn Thr Val Arg Arg Phe Glu Pro Gly Asp Pro Tyr Arg Asn Thr 
        2755                2760                2765            
Leu Gly Leu Pro Leu Gly Asn Thr Arg Leu Tyr Val Leu Gly Asp Gly 
    2770                2775                2780                
Leu Lys Pro Leu Pro Pro Gly Ala Val Gly Glu Leu Tyr Val Ala Gly 
2785                2790                2795                2800
Glu Cys Val Thr Asp Gly Tyr Leu Asn Arg Pro Glu Leu Thr Gly Glu 
                2805                2810                2815    
Arg Phe Leu Pro Asn Pro Phe Asp Thr Gly Glu Glu Gly Arg Glu Gly 
            2820                2825                2830        
Arg His Pro Val Leu Tyr Arg Ser Gly Asp Leu Val Arg Leu Thr Arg 
        2835                2840                2845            
Gly Gly Glu Leu Gln Tyr Leu Gly Arg Asn Asp Ala Gln Leu Lys Ile 
    2850                2855                2860                
Arg Gly Leu Arg Ile Glu Pro Gly Glu Val Glu Ala Val Leu Ala Thr 
2865                2870                2875                2880
Ala Pro Gly Val Arg Glu Cys Ala Val Ala Ala Val Ala Asp Asp Arg 
                2885                2890                2895    
Ser Pro Gly Asn Thr Arg Leu Val Gly Tyr Tyr Val Ala Ala Thr Gly 
            2900                2905                2910        
Thr Glu Thr Asp Thr Asp Thr Gly Thr Gly Asp Ala Gly Gly Ala Asp 
        2915                2920                2925            
Glu Asp Ala Ile Phe Ala Val Leu Arg Ala Arg Leu Met Pro Gly Met 
    2930                2935                2940                
Val Pro Ser Leu Leu Ile Arg Met Asp Gly Pro Leu Pro Met Thr Ile 
2945                2950                2955                2960
Asn Gly Lys Leu Asp Thr Lys Ala Leu Pro Lys Ala Ala Leu Pro Glu 
                2965                2970                2975    
Arg Arg Ala Asp Arg Thr Ala Pro Arg Asn Arg Thr Glu Ala Arg Leu 
            2980                2985                2990        
Cys Gln Leu Trp Gly Asp Arg Leu Pro Gly Gly Thr Val Gly Ile Asp 
        2995                3000                3005            
Asp Asp Phe Phe Arg Ser Gly Gly Asp Ser Ile Ser Ala Leu His Leu 
    3010                3015                3020                
Ala Ser Gln Val Gln Arg Glu Ile Gly Arg Arg Val Gly Val Lys Asp 
3025                3030                3035                3040
Ile Phe Asp His Pro Thr Val Arg His Phe Ala Glu Arg Val Leu Ala 
                3045                3050                3055    
Ala Pro Asp Arg Gly Arg Asp Pro Gly Glu Gly Gly Glu Ala Pro Glu 
            3060                3065                3070        
Gln Gly Arg Leu Asp Gly Asp Cys Pro Leu Leu Pro Ile Gln Glu Trp 
        3075                3080                3085            
Phe Phe Ala Lys Pro Leu Ala Asp Arg Asn Trp Trp Asn His Asn Phe 
    3090                3095                3100                
Ala Val Thr Ala Pro Glu Leu Asp Val Ala Arg Leu Gly Gln Ala Leu 
3105                3110                3115                3120
Ala Arg Leu Val Glu His His Asp Ala Phe Ser Leu Arg Tyr Arg Ser 
                3125                3130                3135    
Glu Gly Gly Gly Asp Gly Ala Asp Glu Arg Phe Val Gln Arg Tyr Asp 
            3140                3145                3150        
Ala Ala Val Pro Glu Val Val Leu His Glu Leu Asp Val Arg Gly Leu 
        3155                3160                3165            
Ser Pro Glu Glu Ile Ser Glu Arg Leu Ala Arg Trp Gln Ser Gly Phe 
    3170                3175                3180                
Asp Leu Glu Arg Gly Pro Ile His Cys Ala Ala Tyr Leu His Gly Phe 
3185                3190                3195                3200
Ala Asp Gly Ser Ala Arg Val Trp Phe Ala Leu His His Leu Val Val 
                3205                3210                3215    
Asp Thr Val Ser Trp His Ile Leu Ala Gln Asp Leu Glu Ile Leu Tyr 
            3220                3225                3230        
His Gly Gly Ala Leu Glu Glu Lys Thr Ser Ser Tyr Arg Gln Trp Ala 
        3235                3240                3245            
Arg Ala Leu Ala Ala Tyr Pro Ala Asp Glu Ala Glu Arg Arg Leu Trp 
    3250                3255                3260                
Ala Glu Ala Val Ala Ser Leu Ala Ala Thr Ala Gln Ala Leu Pro Val 
3265                3270                3275                3280
Pro Ala Pro Gly Ala Ala Thr Leu Arg Glu Glu Phe Ala Leu Asp Ala 
                3285                3290                3295    
Glu Arg Thr Thr Ala Leu Leu Thr Glu Cys His Trp Ala Tyr Asp Thr 
            3300                3305                3310        
Thr Ile Asn Asp Leu Leu Leu Thr Ala Val Gly Gly Ala Leu Arg Ala 
        3315                3320                3325            
Val Thr Gly Leu Ala Val Asn His Val Thr Val Glu Gly His Gly Arg 
    3330                3335                3340                
Glu Arg Phe Asp Gly Ala Pro Asp Val Arg Asp Thr Val Gly Trp Phe 
3345                3350                3355                3360
Thr Thr Met His Pro Leu Ala Val Glu Ala His Pro Gln Asp Val Gly 
                3365                3370                3375    
Arg Gly Ile Thr Ala Thr Lys Glu Ala Ser Arg Arg Val Pro His His 
            3380                3385                3390        
Gly Ile Gly Tyr Gly Ala Leu Phe Gly Arg Tyr Gly Gly Glu Arg Ala 
        3395                3400                3405            
Pro Leu Pro Pro Val Ser Phe Asn Tyr Leu Gly Arg Val Ser Asp Ala 
    3410                3415                3420                
Gly Glu Gln Thr Asp Gly Pro Ser Ala Gly Trp Arg Leu Asp Ser Ala 
3425                3430                3435                3440
Met Ser Gly Ser Asn Ile Ser Gly Arg Asn Arg Gly Ala Asp Gln Phe 
                3445                3450                3455    
Ser Val Asp Val Thr Met Arg Cys Thr Gly Gly Arg Leu Val Thr Ala 
            3460                3465                3470        
Val Asp Ser Arg Leu Asp Glu Glu Thr Thr Arg Arg Phe Thr Asp Glu 
        3475                3480                3485            
Leu Arg Ser Trp Leu Glu Arg Leu Val Ala His Thr Ser Ala Val Ser 
    3490                3495                3500                
Gly Glu Asn Gly Gly Arg Ala Arg Ala Ala Glu Arg Ala Gly Ala Gly 
3505                3510                3515                3520
Thr Glu Phe Asp Pro Tyr Ile Leu Val Asp Gly Asp Arg Ala Glu Arg 
                3525                3530                3535    
Thr Leu Phe Val Phe Pro Pro Gly Glu Gly Gly Ala Glu Ser Tyr Leu 
            3540                3545                3550        
Ser Asn Leu Ala Gln Arg Leu Pro Gly His Arg Leu Val Leu Phe Asn 
        3555                3560                3565            
Asn Val His Leu His Arg Pro Met Glu Ser Phe Glu Ala Leu Ala Asp 
    3570                3575                3580                
Phe Tyr Leu Pro Leu Leu Arg Glu Ile Gln Pro Ser Gly Pro Tyr His 
3585                3590                3595                3600
Leu Leu Gly Trp Ser Phe Gly Gly Val Leu Ser Val Glu Val Ser Leu 
                3605                3610                3615    
Arg Leu Ala Arg Ala Gly Glu Arg Ile Glu Glu Leu Phe Leu Ile Asp 
            3620                3625                3630        
Pro Tyr Phe Asp Val Arg Ala Ser Ser Ala Ala Ile Gly Leu Pro Glu 
        3635                3640                3645            
Thr Glu Asp Ile Leu Asp Pro Ile Asn Tyr His Trp Ala Pro Ala Arg 
    3650                3655                3660                
Glu Asp Leu Glu Arg Leu Arg Ala Asn Thr Gly Asp Val Val Leu Phe 
3665                3670                3675                3680
Arg Ala Asp Glu Pro Asn Glu Ile Val Arg Asp Glu Glu Gln Arg Arg 
                3685                3690                3695    
Leu Phe Asp Phe Tyr Gln Arg Ser Ser Phe Asn Gly Leu Asp Ala Leu 
            3700                3705                3710        
Leu Pro Ala Glu Ser Ile Glu Val His Arg Leu His Gly Glu Thr His 
        3715                3720                3725            
His Ser Trp Val Arg Asn Asp Arg Leu Val Ala Asp Ile Cys Ala Arg 
    3730                3735                3740                
Val Ser Ala Ser Ser Pro Asp Ala Arg 
3745                3750            

<210> 3
<211> 11262
<212> DNA
<213> Streptomyces clavuligerus

<220> 
<221> source
<222> 1..11262
<223> /mol_type="DNA"
      /note="coding region of pcbAB"
      /organism="Streptomyces clavuligerus"

<400> 3
atgctgctga aggacgagtg gcgcaacagg atcgcggtac gggacgacga ccccggtgtc       60

cgtgcgacga ggcagcggga catcgtcgtc gacgggcggg agtacaccgc tctgaaggac      120

gcgctgcgcg ccgccgacgg ggtctcggcg ggcgcgctcg cgctggcctc cctgcacagc      180

gtgatgcgcg cgtacggcca tggcgagcag acggtggcgg cgttcgtcga cgcgacggcg      240

acggcggagc tgaagacggc cgccgtgctg ccggtgatcg tcgaccatat cgagcacacc      300

cggctgacct gcgccgaggc gatccgggag ctggacgaga cgctgcgccg caaggactcc      360

tacacccgtg cggacgaggt gctccagcgg gggctcttcg atgccctgct ggtgctcgcc      420

gagcgcgagg tggccctgtc cgagctgccg tcggccccgc tggtcatggt cgtccgggac      480

gacgcggccc ggggccggct gtgctggacg atggcgtacg cgggcgagct gttcgaggac      540

acgacggtcg ccggtgtgct ggaggtcgtc cgggaggtgc tcgggcagta cgccgggcgg      600

ccgggcgacc gggtcgccga gatcgagctg gcctcgcggg agcagcgcga gcggcttcag      660

cggtggaacg cgaccgatgg cgacttcccg gcggaccagc gcctcaacga cctggtcgag      720

gcggccgtgc ggcggtcgcc ggaccgtgag gcggtcgtct tcgggacaca gcggctgacc      780

tatcgggagg tcgacgcgcg ggcgaaccgg ttcgcgcact ggctgctcgg tccgggtctc      840

ggggtccgtt cgcagcagct cgtcgggatc tttctggaca agagcgatct cggggtggtc      900

gccacgctcg gcatctggaa ggcgggcgcg gcctatgtgc cgatcgaccc ggcctatccg      960

gcggagcggg tgcggttcgc ggtcggtgac accgggctgc ggggcatcgt caccaaccgg     1020

caccacgcgg ggcggctgcg ggagatcctg ggcgcggagc acgcggatgt gacggtcgtc     1080

gagatcgagt ccgtgctcga cgagcaggcc gccgccgaca ccgacggcct gctgagtgtg     1140

aagcccgagc tggcgctggg ggtacgggat ctggcctatc tcacctacac ctccggcacc     1200

accggtgtgc cgaagggggt gcccaagtac cacgacagtg tcgtgaacag catcacggac     1260

ctgtcggagc ggtacgacat gcggcggccg ggcacggagc gggtcgcgct cttcgcctcg     1320

tacgtcttcg agccgcatct gcggcagacg ctgatcgcgc tcatcaacgg gcagacgctg     1380

gtcgtcgtcc ccgaggaggt ccggctcgac ccggaccgct tccccgcgta catcgaggag     1440

cacggcgtca cgtacctcaa cgcgacgggt tcggtgctgc aacacttcga tctgcgccga     1500

tgtaccagcc tgaaacggct gttgctggtc ggcgaggagc tgacggcggc cgggctgcgc     1560

cagctccgcg agcggttctc cgggcggatc gtcaacgagt acgccttcac cgaggcggcg     1620

ttcgtcaccg ccgtgaagga gttcgcgccg ggcgtcaccg agcgcgcgga ccgcagcatc     1680

ggccgaccgg tgcggaatgt gaagtggtat gtcctcagcc aggatctgaa gcggttgccg     1740

gtcggggcga tcggcgagct gtacatcggc ggctgcgggg tggcgccggg ctatctgaac     1800

cgcgacgacc tgacggccga gcggttcctg accaatccgt acgcctcgga gcaggaccgg     1860

gcgcgcggga tgaacgcccg gatctaccgg accggtgacc tggcgcggat gctgccgtcc     1920

ggcgaggtcg agttcatggg ccgcagcgac ttccagctca agctgaacgg tgtccgggtg     1980

gagccgggcg agatcgaggc gcaggccacc gagtatgcgg gggtccgcaa gtgcgtggtc     2040

atcgcccgtg agggggcggg cggcggcagc gaccgccatc tggtcggcta ctacctgacg     2100

gagcccgggg ccggggtgac cgaggcggag ctgctgtcct tcctggagcg gcggctcatc     2160

cggatcatgg tcccggcgcg gatggtccgg ctggagagca tccccgtcaa tgtcaacggc     2220

aaggtcgact ggcgggcgct gcccgaggtg gacctcgccc gcccggacac gggcggcggc     2280

gcggtgggct ccaccacgac cgggggtgtc cggggtgagc tgcgcgagat ctggagcgcg     2340

gtcctcggcc ttccggtgtc ccgtatcggc gacggcgacg acttcttccg gctcggcggc     2400

cagagcatct cctgcattct gctcatcgcc cggatacggc agcggctggg cgtcttcgtc     2460

ggggtcgagg acgtcttcac gctgaggacg ctgggcgcgc tggcggaccg gctggagcgc     2520

gaccggggca cggcgcccgc ggacggcacg ccgcaggagc ggcggtccgc cgagggcaca     2580

gcggacacga cgggcacgga cggtgcggag ggcgcggacg gcgggcccgt gcggctgctc     2640

gcgaacggtc tccagcaggg gctgctctac cacgccctga agcgccgcaa cggcgacgac     2700

gcctatgtga tgcagtcggt gcaccactac cgctgcgcca tccgccccga gctgatgcgc     2760

gaggcgtggc agcacgcgcg gcgcacgtac cccgcgctgc ggctgcgttt cgagtgggcc     2820

gaggaggccc tccagatcgt cgagaacgac gaccgttccg tggactggcg gttcaccgat     2880

ctgagcgggg tggccgaccc ggcggagcag gacgcccgga tccgggagct ccaggagcgg     2940

gaccggaccg agccctacga cccggcggcg ggcgggctgt tccggatcta tctgatccgc     3000

cggagcgaag agttcttctc gctgctgttc agctgccacc acatcatcct ggacggctgg     3060

agcctgccgg tcctccacga cgacgtgcac cggacctatc tgcggctggt ggacggcgag     3120

ccggtcacgg cggacgcggg gagcaccggt acccccggga gcaccgggaa caccgggaac     3180

accgggaaga cggacaccgc gtacatcgcg gcgcagcggg actgggaggc gcaccgcggc     3240

gaccacgtcg actactggac ccgtcagatc gagcggatcg acgagcgggg cgacttcggc     3300

gggctggtcc gggaggacat ccgctaccag gtggcgctga gcgagtacga ccacgtcaag     3360

gagcaccgga cccggcggct cgccctcggt gccgagcgga ccgcggcgct gaaggcggtc     3420

tgcgcggagc actccgtgac cctgcactcg gtgctccagt tcgtgtggca caaggtgctg     3480

tacgccgtcg gcggcgggaa caccacggtg gtcggcacga tcgtgtccgg gcgcaatccg     3540

cacatcgacg ggatcgagaa ctccgtcggt ctgttcatca acacgctgcc cgtgatcgtc     3600

gaccacgacg agcaggcggc gctgggcacg gacgcggcca tcgcggacat ccagtccgcc     3660

gtgaccgcca tggccgcccg gagcacggtg gagctgggcc ggctggagac cggcgggatg     3720

aagcgccgcc tcttcgacac cctgctggtc ctggagaact atccgcggct gctctccgag     3780

gacgaggagc gcgcccacga cgagttgctg cgcttcgaga aggcgtacga cgccgacaag     3840

gtcgactatc cgctggccgt ggtcgcccgc gaggagggtg aggagctgac cgtcaccctc     3900

tggtacgcgg gtgagctgtt cgaggacgcc acgatcgaca ccctgctcgg ggtggcggag     3960

accctgttcg accaggtggc cgaggacatc tcgcgccggg tggaccggct ggagctggtc     4020

tcgcccgcga tggtcgagca gtacggggtg tggaaccgga ccacggcccc gttcccggcc     4080

gggcagaccc tgcacggggt cttcgagcgg caggccgccg cctggccgga cgagaccgcg     4140

gtggtcttcc gcgaccggcg gctgacctac cgggagctga acgagcgcgc caaccggctg     4200

gcgcaccatc tgcgctcggt cgcggagctg cgcccgaacg acctggtcgg cctggtcgtc     4260

gacaagaacg agctgatgat caccgcgatc ctggcggtgt ggaagacggg cgcgggctat     4320

gtcccgatcg acccgggcta ccccgacgac cgggtggcgt tcatgctggc ggacaccagc     4380

gccaagctgg tgatcaccaa ccaggggcgg gtggcgcgga tcggggagct gaccggtggc     4440

gcgctgccgg tggtggatct cgaccggctg cccgacggca acggcgcgga cggcgacccg     4500

gtcaccgatg tcaccgccac ggatctcgcg tacgcgatct acacctccgg caccaccggc     4560

aggcccaagg cggtgctggt cgagcaccgg ggtgtggtga acctccagca ctcgctggcg     4620

aagctgttcg gcctggaccg gagcgagggc gtcgaggcgc tgctgtcgtt ctcgaactac     4680

gtcttcgacc acttcgtgga gcagatgacg gacgccctgc tcaacgggca gaagctggtc     4740

gtcctcgacg acaccatgcg cacggacgcc gagcggctgt accggtacat caacgacgag     4800

caggtcacct atctctccgg cacgccgtcg gtgctctcgc tctacgacta ctcgacgacg     4860

acctcgctga cccggatcga cgcgatcggc gaggacttca ccgagccggt cttcaacaag     4920

atccgcgcca tgttcccggg gacgatcatc aacgggtacg ggccgacgga gatctcgatc     4980

accagccaca agcggcccta cacggtcggc gagcggcggt cgacgaagag catcggccac     5040

ccggtggaca actacacggc ctatgtcctg aacaagtcga tgcagcgggt gccggtcggc     5100

ggcatgggcg agctgtacat cggcggtgtc ggcgtcaccc gcggctatct gaaccgcgac     5160

gagctgacgg cggaccgctt cgtcgacaac cccttccaga ccgccgagga gcgggccgag     5220

gggcgcaacg cgcgcgtcta caagaccggt gacctggtgc gctggctgcc caacggcgag     5280

ctggagtgcc tgggccgcac cgacctccag gtcaagatcc ggggacagcg ggtcgagctg     5340

ggcgaggtcg aggccgcgct ctcctcgtac ccgggcgtca cccgttccct ggtcatcgcg     5400

cgggagcacc ggggcgcggg gctcgcgtcg gcgcagaagt acctcgtggg cttctatgtc     5460

ggcacggacg atctggacga gcaggacgtc aggcagtgga tgcggacgaa gctgcccgag     5520

gcggtcgtcc cctcccgggt gctgcggatc accgacatcc cggtgacgcc gagcggcaag     5580

ctggacgtca cacggctccc ggagaccgac ttcggcccgg gtgacagcgg cgagtacatc     5640

gcgccgtcga acgatgtcga gaccaagctg tgcggcatct gggccacggt gctcggtctc     5700

gccccggagc gggtcggcgt caccgacgac ttcttcgccc tcggcggcga cagcctccgg     5760

gcgatggtgc tggcgcaggc catcaccacc ggcttcggcc ggggtctcgg ggtcgcgacc     5820

gtgctccagc acacgaccct cggggcgcag gcgaagcaca tccgcgagag cgccgcgcac     5880

ggcgacgggg agcaggacgg gccggtcgcg ggccgggccg cggcgggcga cggaaacccg     5940

ccggtgtcgc tcgcgcagga acgtctgctg ttcatcgacg agttcgaggg cggcaccgac     6000

gcctacaaca tccccttcgt cctggagatc gcgaccgggg acgccgcctc gacccgggac     6060

gcggtcaccg gggcgctgcg cgccctgctg gggcggcacg cggcgctgcg caccctgctg     6120

cggaccgacg agcacggcgt ccggcggcag tacccgctgc ccgccgccga ggccgcggcc     6180

cggttcgagg tcccgctgca cacggtcgcg gaccgcacgg ccctggacga gcggctggtg     6240

gagcggtccc gcacggtctt ccggctggac gaggagctgc cgctcgtggc cgacctcttc     6300

acggccggtc cggcggacgg ccgcgcgtat ctgagtctgg tcgtccacca cagcgccttc     6360

gacggctggt cgtggagcac cttccgggag gagctggcgg ccctgctgcg cggtgtcccc     6420

gtgacggatc tgcggcaggt ccacggcagc tacgccgact tctcgctgtg gcagcggcag     6480

tatctgtccg ggggcaggct ggcggagctg accgggtact ggacgggggc gctggccggg     6540

tacgagacga tccggctgcc gctggaccgc ccgcgtccgg cgcgcttcga ctaccggggc     6600

cgggagatcg acttcgacct cgacgagggg acggcgcggg cgctgcgcga gctggcgcgg     6660

tccgcgcggg tgagcctgta cagcgtgctg ctcggcgcgt gggcgctcac cctgcgcgtc     6720

tacaccggcc aggacgactt cgtcgtgggc acgcccgccg cgaaccgggg gcgcccggag     6780

ttcgaccgga ccgtcggctt cttcgcgaac ctgctggcgc tgcgggtccg ggtcgacgcg     6840

gacgccggtc tcgcggagta catccgcgcg gtcggcgcgg acgtggtcgc ggcccaggtc     6900

cacggcgagc tgccgttcga gcagctcgtg aaggagctga acccggagaa ggacccgagc     6960

cggcaccccg tgctccaggt caacttcacc ctccagaacg tcaccgaccg cgctcccgtc     7020

ggcggcgggg ccggggcgga gccggagttc accgagtaca agccggacgc cgggggcttc     7080

acggccacca agttcgatct gtcggcgacg gtcaccgaga acgccgcggg gcggctcgcg     7140

ggcaacctca cctacgccgc cgcgctcttc gacgacgaca ccgccgaagg gttcatcgcc     7200

accttccggc aggtcctcgc ggagttcgcg cggctcgcgg acgccgggga gcaggccagg     7260

gtcgcggagg tggacccggt cggcgcggcg gagcgcgcgg ccctcgcggc cggtcccgcc     7320

ggggccctcc aggccgcggc cgccgaggcg ctgcccgccc cccggaccct gcacacggtc     7380

ttcgaggagc aggccgccgc ctggccggac gccgtcgcgg tcgcccacgg cgcgacccgg     7440

ctcacctacc gggagctgaa cgagcgcgcc aaccagctcg cgcactatct gcgctccgtg     7500

gcgcggatcc gtccgagcga tctgatcggc ctggtcgtcg agaagagcga gctgaccgtc     7560

gtcgcgatcc tcgcggtgtg gaaggcgggc gcgggctatc tgccgatcga cccgggccac     7620

cccgacgacc gggtgacctt catgctggcg gacaccgagg cccggctggt ggtcacccag     7680

cgggcccacg gggagcggct gcgccgcctc gcgggcgacg cgctgccggt ggtggagatc     7740

gacgcgctgc cgcagggcta ccgctcgacc gacgacccgg tcacggacac caccccggcg     7800

gacctcgcgt acgcgatcta cacctcgggc accaccggcc gccccaaggc ggtgctggtt     7860

ccgcaccgcg cggtggacag cttccgcgcg acgctggccg gacggtactt cggcccgccc     7920

gacaccggcc gccagggggt gctgttcctc gccaactatg tcttcgactt ctcggtggag     7980

cagctcgcgc tgtccgtcct cggcggtcac accctgatcg tcccgccgcc gtcgcccgcg     8040

caggacgagc ggttctacga ggacgcgaac cgcgccgggc tgacgtacat cagcgggacg     8100

cccacccagg tccagcagtt cgacctggcg cggctgccgg ggctgcgcac agtgctggtc     8160

gccggtgagg cgttccacga gcgccacttc gagaagatcc gcgagggctg ggcggggccg     8220

atcctcaacg cgtacggcac caccgagacg gccgtctaca acaccgtccg gcgcttcgag     8280

ccgggtgacc cctaccgcaa caccctgggt ctgccgctcg ggaacacccg gctgtacgtc     8340

ctcggcgacg ggctgaagcc gctgccgccg ggcgcggtcg gcgagctgta tgtggccggt     8400

gagtgtgtga cggacggcta tctcaaccgg ccggagctga ccggtgagcg cttcctgccg     8460

aacccgttcg acaccgggga ggaggggcgg gagggccgcc acccggtcct ctaccgcagt     8520

ggcgacctgg tccggctgac ccgcggcggc gagctccagt acctgggccg caacgacgcc     8580

cagctcaaga tccgcgggct gcggatcgag ccgggcgagg tggaggcggt cctcgccacc     8640

gctccggggg tccgcgagtg cgcggtcgcc gccgtggccg acgaccgctc cccggggaac     8700

acccggctgg tcggctacta cgtcgccgcc accggcacgg agacggacac ggacaccggc     8760

acgggcgacg ccgggggcgc cgacgaggac gcgatcttcg cggtgctgcg ggcgcggctg     8820

atgccgggca tggtgccctc gctgctgatc cgcatggacg gcccgctgcc gatgaccatc     8880

aacggcaagc tggacaccaa ggcgctgccg aaggcggcgc tgccggagcg gcgcgcggac     8940

cgcacggccc cgcgcaaccg gaccgaggcc cggctgtgcc agctctgggg cgaccggctc     9000

cccggtggca cggtcggcat cgacgacgac ttcttccgct cgggcggcga cagcatcagc     9060

gccctgcacc tggcgagcca ggtgcagcgg gagatcgggc gcagggtcgg cgtcaaggac     9120

atcttcgacc atccgaccgt ccggcacttc gccgagcggg tgctggccgc cccggaccgg     9180

gggcgggacc ccggcgaggg cggcgaggcg cccgagcagg gccggctgga cggtgactgt     9240

ccgctgctgc ccatccagga gtggttcttc gccaagccgc tcgccgaccg gaactggtgg     9300

aaccacaact tcgccgtcac cgccccggag ctggacgtgg cgaggctggg ccaggcgctg     9360

gcgcggctgg tcgagcacca tgacgcgttc agcctgcggt accgctccga gggcggcggc     9420

gacggcgcgg acgagcggtt cgtccagcgc tacgacgccg ccgtgcccga ggtcgtcctg     9480

cacgagctgg atgtgcgcgg gctctccccc gaggagatct ccgaacggct cgcccgctgg     9540

cagagcggct tcgacctgga gcgcggaccg atccactgcg cggcctatct gcacggcttc     9600

gccgatggct cggcccgggt ctggttcgcc ctgcaccacc tggtcgtcga caccgtgagc     9660

tggcacatcc tcgcgcagga cctggagatc ctgtaccacg ggggcgcgct ggaggagaag     9720

acgagcagct accgccagtg ggcgcgggcg ctcgccgcgt acccggcgga cgaggccgag     9780

cggcggctgt gggcggaggc cgtcgcgtcc ctggcggcca ccgcacaggc gctgccggtc     9840

ccggcgccgg gcgcggcgac gctccgggag gagttcgcgc tcgacgcgga gcggaccacg     9900

gcgctgctga ccgagtgcca ctgggcgtac gacaccacca tcaacgatct gctgctgacg     9960

gcggtcgggg gcgcgctgcg ggccgtcacc ggcctggcgg tcaaccatgt caccgtggag    10020

ggccacggcc gggagcggtt cgacggggcg cccgacgtcc gggacacggt gggctggttc    10080

acgaccatgc acccgctggc cgtggaggcg cacccgcagg acgtggggcg cggcatcacc    10140

gccacgaagg aggcttcccg gcgggtgccg caccacggca tcggatacgg ggccctcttc    10200

ggccgctacg gcggggagcg ggcgccgctg ccgccggtga gcttcaacta cctcggccgg    10260

gtctccgacg ccggggagca gacggacggg ccctccgcgg gctggcggct cgactcggcg    10320

atgtcgggga gcaacatctc cggccgcaac cggggcgccg accagttcag tgtggacgtg    10380

accatgcgat gtaccggcgg ccggctcgtc accgcggtgg acagccgact ggacgaggag    10440

accacccggc gcttcacgga cgagctgagg agctggctgg agcggctcgt cgcccacacc    10500

tcggcggtgt cgggcgagaa cggcggccgg gcgcgcgccg ccgagcgggc cggggccggg    10560

acggagttcg acccgtacat cctcgtcgac ggggaccgcg ccgagcgcac cctcttcgtc    10620

ttcccgcccg gtgagggcgg cgccgagagc tatctgagca atctcgcgca gcggctgccc    10680

ggccaccggc tggtgctctt caacaatgtg catctgcacc ggccgatgga gtccttcgag    10740

gcgctggccg acttctatct ccccctcctc cgggagatcc agccgtccgg cccgtaccac    10800

ctgctgggct ggagcttcgg cggggtgctc tcggtggagg tctcgctccg gctggcccgg    10860

gcgggcgagc ggatcgagga gctgttcctc atcgacccgt acttcgacgt ccgggcctcg    10920

tcggcggcga tcgggctgcc ggagaccgag gacatcctcg atccgatcaa ctaccactgg    10980

gcgcccgccc gggaggatct ggagcggctg cgcgcgaaca ccggcgatgt ggtgctgttc    11040

cgggcggacg agccgaacga gatcgtccgg gacgaggagc agcgccggct gttcgacttc    11100

taccagcggt cctccttcaa cgggctggac gcgctgctgc ccgcggagtc catcgaggtc    11160

caccggctgc acggtgagac ccaccattcg tgggtacgaa acgaccggct ggtcgccgac    11220

atctgtgcgc gtgtctcggc gtcgtcgccg gatgcccggt ga                       11262


<210> 4
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="DNA"
      /note="Oligonucleotide primer codA_XbaI_R   "
      /organism="Artificial Sequence"

<400> 4
gcgctctaga gcgcttgtag tcgatggcct                                     30


<210> 5
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..34
<223> /mol_type="DNA"
      /note="Oligonucleotide primer codA_NdeI_F "
      /organism="Artificial Sequence"

<400> 5
gcggcatatg gttgacatct tttgccgatt ctgg                                 34


<210> 6
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..37
<223> /mol_type="DNA"
      /note="Oligonucleotide primer Apr (aac3)_XbaI_F  "
      /organism="Artificial Sequence"

<400> 6
cgcgtctaga ggatcttcac ctagatcctt ttggttc                              37


<210> 7
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="DNA"
      /note="Oligonucleotide primer ApR(aac3)_EcoRI  "
      /organism="Artificial Sequence"

<400> 7
ccgggaattc cccgatccgc tccacgtg                                       28


<210> 8
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="DNA"
      /note="Oligonucleotide primer pcbAB_L1_F_EcoRI "
      /organism="Artificial Sequence"

<400> 8
gcgcgaattc cgctgacgat cgccgagc                                       28


<210> 9
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="DNA"
      /note="Oligonucleotide primer pcbAB_L1_R_BamHI  "
      /organism="Artificial Sequence"

<400> 9
gcgcggatcc cgttgaggcg ctggtccg                                       28


<210> 10
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..28
<223> /mol_type="DNA"
      /note="Oligonucleotide primer pcbAB_D1_F_BamHI "
      /organism="Artificial Sequence"

<400> 10
gcgcggatcc gcggggtgct ctcggtgg                                       28


<210> 11
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..31
<223> /mol_type="DNA"
      /note="Oligonucleotide primer pcbAB_D1_R_HindIII"
      /organism="Artificial Sequence"

<400> 11
gcgcaagctt agcgagacgg acgacaggga g                                   31


<210> 12
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..23
<223> /mol_type="DNA"
      /note="Oligonucleotide primer pcbAB_conf_F3 "
      /organism="Artificial Sequence"

<400> 12
agctgttcga ggacacgacg gtc                                            23


<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..24
<223> /mol_type="DNA"
      /note=" Oligonucleotide primer pcbAB_conf_R3 "
      /organism="Artificial Sequence"

<400> 13
gacggcatca gaactggcat gaaa                                           24


<210> 14
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..24
<223> /mol_type="DNA"
      /note="Oligonucleotide primer pcbAB_conf_R3_IN "
      /organism="Artificial Sequence"

<400> 14
agtcgacctt gccgttgaca ttga                                           24


<210> 15
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..25
<223> /mol_type="DNA"
      /note="Oligonucleotide primer pcbAB_conf_znotraj_F "
      /organism="Artificial Sequence"

<400> 15
acttccagct caagctgaac ggtgt                                          25


<210> 16
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..24
<223> /mol_type="DNA"
      /note="Oligonucleotide primer pcbAB_conf_znotraj_R "
      /organism="Artificial Sequence"

<400> 16
tccttgacgt ggtcgtactc gctc                                           24


