                         SEQUENCE LISTING

<110>  Cornell University
       DeLisa, Matthew
 
<120>  A PROKARYOTE-BASED CELL-FREE SYSTEM FOR THE SYNTHESIS OF 
       GLYCOPROTEINS

<130>  29543.7021

<150>  US 61/555,854
<151>  2011-11-04

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Bacterial glycosylation motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X at position 1 is D or E

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X at position 2 is any amino acid except proline

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X at position 4 is any amino acid except proline

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X at position 5 is S or T

<400>  1

Xaa Xaa Asn Xaa Xaa 
1               5   


<210>  2
<211>  664
<212>  PRT
<213>  Campylobacter jejuni

<400>  2

Ile Ile Ser Asn Asp Gly Tyr Ala Phe Ala Glu Gly Ala Arg Asp Met 
1               5                   10                  15      


Ile Ala Gly Phe His Gln Pro Asn Asp Leu Ser Tyr Tyr Gly Ser Ser 
            20                  25                  30          


Leu Ser Thr Leu Thr Tyr Trp Leu Tyr Lys Ile Thr Pro Phe Ser Phe 
        35                  40                  45              


Glu Ser Ile Ile Leu Tyr Met Ser Thr Phe Leu Ser Ser Leu Val Val 
    50                  55                  60                  


Ile Pro Ile Ile Leu Leu Ala Asn Glu Tyr Lys Arg Pro Leu Met Gly 
65                  70                  75                  80  


Phe Val Ala Ala Leu Leu Ala Ser Ile Ala Asn Ser Tyr Tyr Asn Arg 
                85                  90                  95      


Thr Met Ser Gly Tyr Tyr Asp Thr Asp Met Leu Val Ile Val Leu Pro 
            100                 105                 110         


Met Phe Ile Leu Phe Phe Met Val Arg Met Ile Leu Lys Lys Asp Phe 
        115                 120                 125             


Phe Ser Leu Ile Ala Leu Pro Leu Phe Ile Gly Ile Tyr Leu Trp Trp 
    130                 135                 140                 


Tyr Pro Ser Ser Tyr Thr Leu Asn Val Ala Leu Ile Gly Leu Phe Leu 
145                 150                 155                 160 


Ile Tyr Thr Leu Ile Phe His Arg Lys Glu Lys Ile Phe Tyr Ile Ala 
                165                 170                 175     


Val Ile Leu Ser Ser Leu Thr Leu Ser Asn Ile Ala Trp Phe Tyr Gln 
            180                 185                 190         


Ser Thr Ile Ile Val Ile Leu Phe Ala Leu Phe Ala Leu Glu Gln Lys 
        195                 200                 205             


Arg Leu Asn Phe Val Ile Ile Gly Ile Leu Ala Ser Val Thr Leu Ile 
    210                 215                 220                 


Phe Leu Ile Leu Ser Gly Gly Val Asp Pro Ile Leu Tyr Gln Leu Lys 
225                 230                 235                 240 


Phe Tyr Ile Phe Arg Ser Asp Glu Ser Ala Asn Leu Thr Gln Gly Phe 
                245                 250                 255     


Met Tyr Phe Asn Val Asn Gln Thr Ile Gln Glu Val Glu Asn Val Asp 
            260                 265                 270         


Leu Ser Glu Phe Met Arg Arg Ile Ser Gly Ser Glu Ile Val Phe Leu 
        275                 280                 285             


Phe Ser Leu Phe Gly Phe Val Trp Leu Leu Arg Lys His Lys Ser Met 
    290                 295                 300                 


Ile Met Ala Leu Pro Ile Leu Val Leu Gly Phe Leu Ala Leu Lys Gly 
305                 310                 315                 320 


Gly Leu Arg Phe Thr Ile Tyr Ser Val Pro Val Met Ala Leu Gly Phe 
                325                 330                 335     


Gly Phe Leu Leu Ser Glu Phe Lys Ala Ile Leu Val Lys Lys Tyr Ser 
            340                 345                 350         


Gln Leu Thr Ser Asn Val Cys Ile Val Phe Ala Thr Ile Leu Thr Leu 
        355                 360                 365             


Ala Pro Val Phe Ile His Ile Tyr Asn Tyr Lys Ala Pro Thr Val Phe 
    370                 375                 380                 


Ser Gln Asn Glu Ala Ser Leu Leu Asn Gln Leu Lys Asn Ile Ala Asn 
385                 390                 395                 400 


Arg Glu Asp Tyr Val Val Thr Trp Trp Asp Tyr Gly Tyr Pro Val Arg 
                405                 410                 415     


Tyr Tyr Ser Asp Val Lys Thr Leu Val Asp Gly Gly Lys His Leu Gly 
            420                 425                 430         


Lys Asp Asn Phe Phe Pro Ser Phe Ala Leu Ser Lys Asp Glu Gln Ala 
        435                 440                 445             


Ala Ala Asn Met Ala Arg Leu Ser Val Glu Tyr Thr Glu Lys Ser Phe 
    450                 455                 460                 


Tyr Ala Pro Gln Asn Asp Ile Leu Lys Thr Asp Ile Leu Gln Ala Met 
465                 470                 475                 480 


Met Lys Asp Tyr Asn Gln Ser Asn Val Asp Leu Phe Leu Ala Ser Leu 
                485                 490                 495     


Ser Lys Pro Asp Phe Lys Ile Asp Thr Pro Lys Thr Arg Asp Ile Tyr 
            500                 505                 510         


Leu Tyr Met Pro Ala Arg Met Ser Leu Ile Phe Ser Thr Val Ala Ser 
        515                 520                 525             


Phe Ser Phe Ile Asn Leu Asp Thr Gly Val Leu Asp Lys Pro Phe Thr 
    530                 535                 540                 


Phe Ser Thr Ala Tyr Pro Leu Asp Val Lys Asn Gly Glu Ile Tyr Leu 
545                 550                 555                 560 


Ser Asn Gly Val Val Leu Ser Asp Asp Phe Arg Ser Phe Lys Ile Gly 
                565                 570                 575     


Asp Asn Val Val Ser Val Asn Ser Ile Val Glu Ile Asn Ser Ile Lys 
            580                 585                 590         


Gln Gly Glu Tyr Lys Ile Thr Pro Ile Asp Asp Lys Ala Gln Phe Tyr 
        595                 600                 605             


Ile Phe Tyr Leu Lys Asp Ser Ala Ile Pro Tyr Ala Gln Phe Ile Leu 
    610                 615                 620                 


Met Asp Lys Thr Met Phe Asn Ser Ala Tyr Val Gln Met Phe Phe Leu 
625                 630                 635                 640 


Gly Asn Tyr Asp Lys Asn Leu Phe Asp Leu Val Ile Asn Ser Arg Asp 
                645                 650                 655     


Ala Lys Val Phe Lys Leu Lys Ile 
            660                 


<210>  3
<211>  1995
<212>  DNA
<213>  Campylobacter jejuni

<400>  3
atcatttcaa acgatggtta tgcttttgct gagggtgcaa gagatatgat agcaggtttt       60

catcagccta atgatttgag ttattatgga tcttctttat ctacgcttac ttattggctt      120

tataaaatca cacctttttc tttcgaaagt attattttat atatgagtac ttttttatct      180

tctttggtgg tgattcctat tattttacta gctaatgaat acaaacgtcc tttaatgggc      240

tttgtagctg ctcttttagc aagtatagca aacagttatt ataatcgcac tatgagtggg      300

tattatgata cggatatgct ggtaattgtt ttacctatgt ttattttatt ttttatggta      360

agaatgattt taaaaaaaga ctttttttca ttgattgcct taccgttatt tataggaatt      420

tatctttggt ggtatccttc aagctatact ttaaatgtag ctttaattgg acttttttta      480

atttatacac ttatttttca tagaaaagaa aagatttttt atatagctgt gattttgtct      540

tctcttactc tttcaaatat agcatggttt tatcaaagta ctattatagt aatacttttt      600

gctttatttg ctttagagca aaaacgctta aattttgtaa ttataggaat tttagctagt      660

gtaactttga tatttttgat tttaagtgga ggggttgatc ctatacttta tcagcttaaa      720

ttttatattt ttagaagtga tgaaagtgcg aatttaacgc agggttttat gtattttaat      780

gtcaatcaaa ccatacaaga agttgaaaat gtagatctta gcgaatttat gcgaagaatt      840

agtggtagtg aaattgtttt tttgttttct ttgtttggtt ttgtatggct tttgagaaaa      900

cataaaagta tgattatggc tttacctata ttggtgcttg ggtttttagc cttaaaaggg      960

gggcttagat ttaccattta ttctgtacct gtaatggcct taggatttgg ttttttattg     1020

agcgagttta aggctatatt ggttaaaaaa tatagccaat taacttcaaa tgtttgtatt     1080

gtttttgcaa ctattttgac tttagctcca gtatttatcc atatttacaa ctataaagca     1140

ccaacagttt tttctcaaaa tgaagcatca ttattaaatc aattaaaaaa tatagccaat     1200

agagaagatt atgtggtaac ttggtgggat tatggttatc ctgtgcgtta ttatagtgat     1260

gtgaaaactt tagtagatgg tggaaagcat ttaggtaagg ataatttttt cccttctttt     1320

gctttaagca aagatgaaca agctgcagct aatatggcaa gacttagtgt agaatataca     1380

gaaaaaagct tttatgctcc gcaaaatgat attttaaaaa cagacatttt acaagccatg     1440

atgaaagatt ataatcaaag caatgtggat ttgtttctag cttcattatc aaaacctgat     1500

tttaaaatcg atacaccaaa aactcgtgat atttatcttt atatgcccgc tagaatgtct     1560

ttgatttttt ctacggtggc tagtttttct tttattaatt tagatacagg agttttggat     1620

aaacctttta cctttagcac agcttatcca cttgatgtta aaaatggaga aatttatctt     1680

agcaacggag tggttttaag cgatgatttt agaagtttta aaataggtga taatgtggtt     1740

tctgtaaata gtatcgtaga gattaattct attaaacaag gtgaatacaa aatcactcca     1800

attgatgata aggctcagtt ttatattttt tatttaaagg atagtgctat tccttacgca     1860

caatttattt taatggataa aaccatgttt aatagtgctt atgtgcaaat gtttttttta     1920

ggaaattatg ataagaattt atttgacttg gtgattaatt ctagagatgc taaggttttt     1980

aaacttaaaa tttaa                                                      1995


<210>  4
<211>  711
<212>  PRT
<213>  Campylobacter lari

<400>  4

Met Lys Leu Gln Gln Asn Phe Thr Asp Asn Asn Ser Ile Lys Tyr Thr 
1               5                   10                  15      


Cys Ile Leu Ile Leu Ile Ala Phe Ala Phe Ser Val Leu Cys Arg Leu 
            20                  25                  30          


Tyr Trp Val Ala Trp Ala Ser Glu Phe Tyr Glu Phe Phe Phe Asn Asp 
        35                  40                  45              


Gln Leu Met Ile Thr Thr Asn Asp Gly Tyr Ala Phe Ala Glu Gly Ala 
    50                  55                  60                  


Arg Asp Met Ile Ala Gly Phe His Gln Pro Asn Asp Leu Ser Tyr Phe 
65                  70                  75                  80  


Gly Ser Ser Leu Ser Thr Leu Thr Tyr Trp Leu Tyr Ser Ile Leu Pro 
                85                  90                  95      


Phe Ser Phe Glu Ser Ile Ile Leu Tyr Met Ser Ala Phe Phe Ala Ser 
            100                 105                 110         


Leu Ile Val Val Pro Ile Ile Leu Ile Ala Arg Glu Tyr Lys Leu Thr 
        115                 120                 125             


Thr Tyr Gly Phe Ile Ala Ala Leu Leu Gly Ser Ile Ala Asn Ser Tyr 
    130                 135                 140                 


Tyr Asn Arg Thr Met Ser Gly Tyr Tyr Asp Thr Asp Met Leu Val Leu 
145                 150                 155                 160 


Val Leu Pro Met Leu Ile Leu Leu Thr Phe Ile Arg Leu Thr Ile Asn 
                165                 170                 175     


Lys Asp Ile Phe Thr Leu Leu Leu Ser Pro Val Phe Ile Met Ile Tyr 
            180                 185                 190         


Leu Trp Trp Tyr Pro Ser Ser Tyr Ser Leu Asn Phe Ala Met Ile Gly 
        195                 200                 205             


Leu Phe Gly Leu Tyr Thr Leu Val Phe His Arg Lys Glu Lys Ile Phe 
    210                 215                 220                 


Tyr Leu Thr Ile Ala Leu Met Ile Ile Ala Leu Ser Met Leu Ala Trp 
225                 230                 235                 240 


Gln Tyr Lys Leu Ala Leu Ile Val Leu Leu Phe Ala Ile Phe Ala Phe 
                245                 250                 255     


Lys Glu Glu Lys Ile Asn Phe Tyr Met Ile Trp Ala Leu Ile Phe Ile 
            260                 265                 270         


Ser Ile Leu Ile Leu His Leu Ser Gly Gly Leu Asp Pro Val Leu Tyr 
        275                 280                 285             


Gln Leu Lys Phe Tyr Val Phe Lys Ala Ser Asp Val Gln Asn Leu Lys 
    290                 295                 300                 


Asp Ala Ala Phe Met Tyr Phe Asn Val Asn Glu Thr Ile Met Glu Val 
305                 310                 315                 320 


Asn Thr Ile Asp Pro Glu Val Phe Met Gln Arg Ile Ser Ser Ser Val 
                325                 330                 335     


Leu Val Phe Ile Leu Ser Phe Ile Gly Phe Ile Leu Leu Cys Lys Asp 
            340                 345                 350         


His Lys Ser Met Leu Leu Ala Leu Pro Met Leu Ala Leu Gly Phe Met 
        355                 360                 365             


Ala Leu Arg Ala Gly Leu Arg Phe Thr Ile Tyr Ala Val Pro Val Met 
    370                 375                 380                 


Ala Leu Gly Phe Gly Tyr Phe Leu Tyr Ala Phe Phe Asn Phe Leu Glu 
385                 390                 395                 400 


Lys Lys Gln Ile Lys Leu Ser Leu Arg Asn Lys Asn Ile Leu Leu Ile 
                405                 410                 415     


Leu Ile Ala Phe Phe Ser Ile Ser Pro Ala Leu Met His Ile Tyr Tyr 
            420                 425                 430         


Tyr Lys Ser Ser Thr Val Phe Thr Ser Tyr Glu Ala Ser Ile Leu Asn 
        435                 440                 445             


Asp Leu Lys Asn Lys Ala Gln Arg Glu Asp Tyr Val Val Ala Trp Trp 
    450                 455                 460                 


Asp Tyr Gly Tyr Pro Ile Arg Tyr Tyr Ser Asp Val Lys Thr Leu Ile 
465                 470                 475                 480 


Asp Gly Gly Lys His Leu Gly Lys Asp Asn Phe Phe Ser Ser Phe Val 
                485                 490                 495     


Leu Ser Lys Glu Gln Ile Pro Ala Ala Asn Met Ala Arg Leu Ser Val 
            500                 505                 510         


Glu Tyr Thr Glu Lys Ser Phe Lys Glu Asn Tyr Pro Asp Val Leu Lys 
        515                 520                 525             


Ala Met Val Lys Asp Tyr Asn Lys Thr Ser Ala Lys Asp Phe Leu Glu 
    530                 535                 540                 


Ser Leu Asn Asp Lys Asp Phe Lys Phe Asp Thr Asn Lys Thr Arg Asp 
545                 550                 555                 560 


Val Tyr Ile Tyr Met Pro Tyr Arg Met Leu Arg Ile Met Pro Val Val 
                565                 570                 575     


Ala Gln Phe Ala Asn Thr Asn Pro Asp Asn Gly Glu Gln Glu Lys Ser 
            580                 585                 590         


Leu Phe Phe Ser Gln Ala Asn Ala Ile Ala Gln Asp Lys Thr Thr Gly 
        595                 600                 605             


Ser Val Met Leu Asp Asn Gly Val Glu Ile Ile Asn Asp Phe Arg Ala 
    610                 615                 620                 


Leu Lys Val Glu Gly Ala Ser Ile Pro Leu Lys Ala Phe Val Asp Ile 
625                 630                 635                 640 


Glu Ser Ile Thr Asn Gly Lys Phe Tyr Tyr Asn Glu Ile Asp Ser Lys 
                645                 650                 655     


Ala Gln Ile Tyr Leu Leu Phe Leu Arg Glu Tyr Lys Ser Phe Val Ile 
            660                 665                 670         


Leu Asp Glu Ser Leu Tyr Asn Ser Ser Tyr Ile Gln Met Phe Leu Leu 
        675                 680                 685             


Asn Gln Tyr Asp Gln Asp Leu Phe Glu Gln Ile Thr Asn Asp Thr Arg 
    690                 695                 700                 


Ala Lys Ile Tyr Arg Leu Lys 
705                 710     


<210>  5
<211>  2139
<212>  DNA
<213>  Campylobacter lari

<400>  5
atgaaactac aacaaaattt cacggataat aattctataa aatatacctg tattttaatc       60

cttatagcct ttgcttttag tgttttgtgt agattatact gggtagcttg ggcaagtgag      120

ttttatgagt ttttctttaa tgatcaactc atgattacta ctaatgatgg ctatgctttt      180

gcagaaggtg caagagatat gatagcaggt tttcatcaac ctaatgactt atcttatttt      240

ggaagctcac tttctacttt gacttattgg ctttatagta ttttgccttt tagctttgaa      300

agtattattt tatatatgag tgcttttttt gcttctttga ttgttgtgcc tattatatta      360

atcgcaagag agtataaact cactacctat ggctttatag cagctttact tggaagcatt      420

gcaaatagtt attataaccg cactatgagt gggtattacg atacagatat gctagtgtta      480

gttttaccaa tgcttatttt gcttaccttt atacgcttaa ctattaataa agacattttc      540

accctacttt taagtccggt ttttatcatg atttatttgt ggtggtatcc atcaagttat      600

tctttaaatt ttgctatgat aggacttttt ggactttata ctttagtatt tcatagaaaa      660

gaaaagattt tttatctaac tattgctttg atgatcatag ctttaagtat gctagcatgg      720

caatataagc ttgctttgat tgtattatta tttgctattt ttgcttttaa agaagaaaaa      780

atcaattttt atatgatttg ggctttgatt tttattagca ttttgatatt gcatttaagt      840

ggcggcttag atcctgtttt ataccaactt aaattttatg tatttaaagc ttctgatgtg      900

caaaatttaa aagatgctgc ctttatgtat tttaatgtca atgaaaccat tatggaagta      960

aatactatcg atcctgaagt atttatgcaa agaattagct ctagtgtttt agtatttatc     1020

ctttctttta taggttttat cttactttgc aaagatcaca aaagcatgct tttggctcta     1080

cctatgcttg cactaggttt tatggcttta agagctggac ttagatttac catttatgca     1140

gttcctgtga tggctttggg ttttgggtat tttttatatg cattttttaa ttttttagaa     1200

aaaaaacaaa tcaaacttag cctaagaaat aaaaatatct tacttatact cattgcattt     1260

tttagtataa gccctgcttt gatgcatatt tattattata aatcctctac tgtttttact     1320

tcttatgaag ctagtatttt aaatgattta aaaaataaag ctcaaagaga agattatgtt     1380

gttgcttggt gggattatgg ttatccaata cgctattata gcgatgtaaa aaccttaatc     1440

gatggtggaa aacacctagg aaaagataat tttttctcat cttttgtctt aagcaaagaa     1500

caaattccag cagccaatat ggcaagactt agcgtagaat acactgaaaa atctttcaaa     1560

gaaaactatc ctgatgtttt aaaagctatg gttaaagatt ataataaaac aagtgctaaa     1620

gattttttag aaagtttaaa tgataaagat tttaaatttg ataccaataa aactagagat     1680

gtatacattt atatgcctta tagaatgttg cgtatcatgc ctgtggtggc acaatttgca     1740

aatacaaatc ctgataatgg agagcaagaa aaaagtttat ttttctccca agctaatgcc     1800

atagctcaag ataaaaccac aggttctgtt atgcttgata atggagtaga aattattaat     1860

gattttagag ccttaaaagt agaaggtgca agcatacctt taaaagcttt tgtggatata     1920

gaatccatta ctaatggcaa attttattac aatgaaattg attcaaaagc tcaaatttat     1980

ttgctctttt taagagaata taaaagcttt gtgattttag atgaaagtct ttataatagt     2040

tcttatatac aaatgttttt gttaaatcaa tacgatcaag atttatttga acaaattact     2100

aatgatacaa gagcaaaaat ttataggcta aaaagatga                            2139


<210>  6
<211>  714
<212>  PRT
<213>  Campylobacter coli

<400>  6

Met Leu Lys Lys Glu Tyr Phe Lys Asn Pro Thr Phe Ile Leu Leu Ala 
1               5                   10                  15      


Phe Ile Ile Leu Ala Tyr Val Phe Ser Val Leu Cys Arg Phe Tyr Trp 
            20                  25                  30          


Ile Phe Trp Ala Ser Glu Phe Asn Glu Tyr Phe Phe Asn Asn Glu Leu 
        35                  40                  45              


Met Ile Ile Ser Asn Asp Gly Tyr Ala Phe Ala Glu Gly Ala Arg Asp 
    50                  55                  60                  


Met Ile Ala Gly Phe His Gln Pro Asn Asp Leu Ser Tyr Tyr Gly Ser 
65                  70                  75                  80  


Ser Leu Ser Thr Leu Thr Tyr Trp Phe Tyr Lys Ile Thr Pro Phe Ser 
                85                  90                  95      


Leu Glu Ser Ile Phe Ile Tyr Ile Ser Thr Phe Leu Ser Ser Leu Val 
            100                 105                 110         


Val Ile Pro Leu Ile Leu Ile Ala Asn Glu Tyr Lys Arg Pro Leu Met 
        115                 120                 125             


Gly Phe Val Ala Ala Leu Leu Ala Ser Ile Ala Asn Ser Tyr Tyr Asn 
    130                 135                 140                 


Arg Thr Met Ser Gly Tyr Tyr Asp Thr Asp Met Leu Val Ile Val Leu 
145                 150                 155                 160 


Ala Met Met Ile Val Phe Phe Met Ile Arg Leu Ile Leu Lys Lys Asp 
                165                 170                 175     


Leu Leu Ser Leu Ile Thr Leu Pro Leu Phe Val Gly Ile Tyr Leu Trp 
            180                 185                 190         


Trp Tyr Pro Ser Ser Tyr Thr Leu Asn Val Ala Leu Leu Gly Leu Phe 
        195                 200                 205             


Phe Ile Tyr Thr Leu Val Phe His Ile Lys Glu Lys Thr Leu Tyr Met 
    210                 215                 220                 


Ala Ile Ile Leu Ala Ser Ile Thr Leu Ser Asn Ile Ala Trp Phe Tyr 
225                 230                 235                 240 


Gln Ser Ala Ile Ile Val Ile Leu Phe Ser Leu Phe Val Leu Gln Asn 
                245                 250                 255     


Lys Arg Phe Ser Phe Ala Leu Leu Gly Ile Leu Gly Leu Ala Thr Leu 
            260                 265                 270         


Val Phe Leu Ile Leu Ser Gly Gly Ile Asp Pro Ile Leu Tyr Gln Leu 
        275                 280                 285             


Lys Phe Tyr Ile Phe Arg Ser Asp Glu Ser Ala Asn Leu Ala Gln Gly 
    290                 295                 300                 


Phe Met Tyr Phe Asn Val Asn Gln Thr Ile Gln Glu Val Glu Ser Ile 
305                 310                 315                 320 


Asp Leu Ser Ile Phe Met Gln Arg Ile Ser Gly Ser Glu Leu Val Phe 
                325                 330                 335     


Phe Val Ser Leu Ile Gly Phe Ile Phe Leu Val Arg Lys His Lys Ser 
            340                 345                 350         


Met Ile Leu Ala Leu Pro Met Leu Ala Leu Gly Phe Leu Ala Leu Lys 
        355                 360                 365             


Ser Gly Leu Arg Phe Thr Ile Tyr Ala Val Pro Val Leu Ala Leu Gly 
    370                 375                 380                 


Phe Gly Phe Leu Met Ser Leu Leu Gln Glu Arg Lys Gln Lys Asn Asn 
385                 390                 395                 400 


Asn Thr Tyr Trp Trp Ala Asn Ile Gly Val Phe Ile Phe Thr Phe Leu 
                405                 410                 415     


Ser Leu Ile Pro Met Phe Tyr His Ile Asn Asn Tyr Lys Ala Pro Thr 
            420                 425                 430         


Val Phe Ser Gln Asn Glu Ala Thr Lys Leu Asp Glu Leu Lys Lys Ile 
        435                 440                 445             


Ala Gln Arg Glu Asp Tyr Val Val Thr Trp Trp Asp Tyr Gly Tyr Pro 
    450                 455                 460                 


Ile Arg Tyr Tyr Ser Asp Val Lys Thr Leu Ala Asp Gly Gly Lys His 
465                 470                 475                 480 


Leu Gly Lys Asp Asn Phe Phe Pro Ser Phe Val Leu Ser Lys Asp Gln 
                485                 490                 495     


Val Ala Ala Ala Asn Met Ala Arg Leu Ser Val Glu Tyr Thr Glu Lys 
            500                 505                 510         


Ser Phe Tyr Ala Pro Leu Asn Asp Ile Leu Lys Asn Asp Leu Leu Gln 
        515                 520                 525             


Ala Met Met Lys Asp Tyr Asn Gln Asn Asn Val Asp Leu Phe Leu Ala 
    530                 535                 540                 


Ser Leu Ser Lys Pro Asp Phe Lys Ile Asn Thr Pro Lys Thr Arg Asp 
545                 550                 555                 560 


Val Tyr Ile Tyr Met Pro Ala Arg Met Ser Leu Ile Phe Ser Thr Val 
                565                 570                 575     


Ala Ser Phe Ser Phe Val Asp Leu Glu Thr Gly Glu Ile Asn Lys Pro 
            580                 585                 590         


Phe Thr Phe Ser Ala Ala Tyr Pro Leu Asp Val Lys Asn Gly Glu Ile 
        595                 600                 605             


Tyr Leu Ser Asn Gly Ile Ala Leu Ser Asp Asp Phe Arg Ser Phe Lys 
    610                 615                 620                 


Ile Asn Asn Ser Thr Ile Ser Val Asn Ser Ile Ile Glu Ile Asn Ser 
625                 630                 635                 640 


Ile Lys Gln Gly Glu Tyr Lys Ile Thr Pro Ile Asp Asp Met Ala Gln 
                645                 650                 655     


Phe Tyr Ile Phe Tyr Leu Lys Asp Ser Thr Ile Pro Tyr Ala Gln Phe 
            660                 665                 670         


Ile Leu Met Asp Lys Thr Met Phe Asn Ser Ala Tyr Val Gln Met Phe 
        675                 680                 685             


Phe Leu Gly Asn Tyr Asp Lys Asn Leu Tyr Asp Leu Val Ile Asn Ala 
    690                 695                 700                 


Arg Asp Ala Lys Val Phe Lys Leu Lys Ile 
705                 710                 


<210>  7
<211>  2145
<212>  DNA
<213>  Campylobacter coli

<400>  7
atgttaaaaa aagaatactt taaaaaccca acttttattt tattggcttt tataatttta       60

gcgtatgtct ttagtgtttt atgtaggttt tattggattt tttgggcaag tgagtttaat      120

gaatattttt tcaataacga gcttatgatt atctcaaatg atggatatgc ttttgcagag      180

ggtgcaagag atatgatagc gggttttcat caacctaatg atttgagtta ttatggttct      240

tcgctttcaa cgctcacata ttggttttat aaaataactc ctttttcttt agaaagcatt      300

tttatatata tcagtacttt tttatcttct ttggtggtta tacctttgat tttgattgct      360

aatgaataca aacgcccttt aatggggttt gttgcagcat tgctagccag tatagctaat      420

agctattata atcgcacgat gagcggatat tatgatactg atatgcttgt tatagttctt      480

gcaatgatga tagttttctt tatgataagg ctgattttga aaaaagattt attatcttta      540

ataacactgc ctttgtttgt aggaatttat ctttggtggt atccatcaag ctatacttta      600

aatgttgctt tactaggact tttctttatt tataccttgg tttttcatat aaaagaaaaa      660

acgctttata tggctattat cctagcttct atcacacttt caaatatagc ttggttttat      720

caaagcgcca tcattgtcat actttttagt ctttttgttt tgcaaaataa gcgttttagc      780

tttgctttgc ttggaatttt aggtttggca actttggtat ttttgatact aagcggtgga      840

attgatccta tactctatca acttaaattt tatattttta gaagtgatga gagtgcaaat      900

ttggctcaag gttttatgta ttttaatgta aatcaaacca tacaagaggt agaaagtata      960

gatttaagta tttttatgca aaggattagc ggaagcgagc ttgtattttt tgtatcttta     1020

atcggcttta ttttccttgt tagaaaacat aaaagtatga ttttggcttt gccgatgtta     1080

gctttaggat ttttagcact taagagtgga cttcgtttta ctatttatgc agtacctgtt     1140

ttagcacttg gatttggttt tttaatgagt cttttgcaag aaagaaaaca aaaaaacaat     1200

aatacctatt ggtgggccaa tataggcgtt tttattttta cttttttaag tttaattcct     1260

atgttctatc atatcaacaa ttataaagca ccaactgttt tttctcaaaa tgaggctacg     1320

aaattagatg agcttaaaaa aattgcacaa agagaagatt atgtagtaac ttggtgggat     1380

tatggatatc ctattaggta ttacagcgat gttaaaactt tggctgatgg gggtaagcat     1440

ttaggcaagg ataatttttt cccatctttt gttctaagta aagatcaagt ggctgctgca     1500

aatatggcaa gacttagtgt agaatacaca gaaaaaagtt tttacgcccc tttaaatgat     1560

attttaaaaa atgatctttt acaagccatg atgaaagatt ataatcaaaa taatgtggat     1620

ttgtttttag cttcgctttc caagcctgat tttaaaatca atacgccaaa aacacgcgat     1680

gtgtatatct atatgccagc tagaatgtct ttgatttttt caactgtggc tagtttttct     1740

tttgtggatt tggagacagg tgagataaat aaacctttta cttttagtgc agcttatcca     1800

cttgatgtta aaaatggaga aatttatctt agcaatggta ttgcattaag tgatgatttt     1860

agaagtttta aaataaataa tagtactata tccgtaaata gtatcataga gattaattct     1920

atcaaacaag gtgaatataa aatcactcct attgatgata tggctcaatt ttatattttt     1980

tatcttaaag atagcaccat accttatgct cagtttattt taatggataa aactatgttt     2040

aatagtgctt atgtgcaaat gtttttcctt ggaaattatg ataaaaattt gtatgattta     2100

gtgattaatg ctagagatgc aaaagttttt aaactcaaaa tttaa                     2145


<210>  8
<211>  785
<212>  PRT
<213>  Campylobacter upsaliensis

<400>  8

Met Lys Asn Glu Ala Val Lys Asn Ala Asn Leu Arg Leu Val Phe Phe 
1               5                   10                  15      


Ile Leu Leu Ala Phe Gly Phe Ser Val Leu Cys Arg Phe Tyr Trp Ile 
            20                  25                  30          


Tyr Trp Ala Ser Asp Phe Asn Glu Tyr Phe Phe Asn Asn Gln Leu Met 
        35                  40                  45              


Ile Ser Ser Asn Asp Gly Tyr Thr Phe Ala Glu Gly Ala Arg Asp Lys 
    50                  55                  60                  


Ile Ala Gly Phe His Gln Glu Asn Asp Leu Ser Phe Ile Asn Ser Ser 
65                  70                  75                  80  


Leu Ser Ile Leu Thr Tyr Val Leu Tyr Lys Ile Thr Pro Phe Ser Phe 
                85                  90                  95      


Glu Ser Ile Ile Leu Tyr Met Ser Val Phe Phe Ser Ser Leu Ile Val 
            100                 105                 110         


Val Pro Leu Ile Leu Ile Ala Asn Glu Leu Lys Arg Pro Leu Met Gly 
        115                 120                 125             


Leu Phe Ala Ala Phe Leu Ala Ser Ile Ala Lys Ser Tyr Tyr Asn Arg 
    130                 135                 140                 


Thr Met Ala Gly Tyr Tyr Asp Thr Asp Met Leu Ala Ile Val Leu Pro 
145                 150                 155                 160 


Met Phe Ile Leu Tyr Phe Phe Ile Arg Leu Ile Leu Arg Lys Asp Asp 
                165                 170                 175     


Phe Ser Leu Leu Ala Leu Pro Phe Phe Met Gly Leu Tyr Leu Trp Trp 
            180                 185                 190         


Tyr Pro Ser Ser Tyr Thr Leu Asn Val Ala Phe Ile Ala Leu Phe Thr 
        195                 200                 205             


Leu Tyr Val Leu Ile Tyr His Arg Lys Glu Arg Ser Phe Tyr Met Ala 
    210                 215                 220                 


Ala Leu Leu Cys Ala Ile Thr Leu Ser Asn Ile Ala Trp Phe Tyr Gln 
225                 230                 235                 240 


Ser Ala Ile Ile Val Leu Leu Phe Ala Leu Phe Met Leu Lys Asn Ser 
                245                 250                 255     


Phe Phe Asn Phe Lys Phe Ile Ala Leu Leu Ala Leu Gly Val Leu Val 
            260                 265                 270         


Phe Leu Ala Leu Ser Gly Gly Ile Asp Pro Ile Leu Tyr Gln Leu Lys 
        275                 280                 285             


Phe Tyr Leu Leu Arg Ser Asp Glu Ser Ala Ser Leu Ala Arg Gly Phe 
    290                 295                 300                 


Ala Tyr Phe Asn Val Asn Leu Thr Ile Gln Glu Val Glu Ser Ile Asp 
305                 310                 315                 320 


Leu Ser Thr Phe Met Gln Arg Ile Ser Gly Ser Glu Leu Val Phe Leu 
                325                 330                 335     


Leu Ser Leu Phe Gly Phe Leu Trp Leu Leu Lys Lys His Lys Val Met 
            340                 345                 350         


Leu Leu Thr Leu Pro Met Leu Leu Leu Gly Phe Leu Ala Leu Arg Gly 
        355                 360                 365             


Gly Leu Arg Phe Thr Ile Tyr Ala Val Pro Ile Met Ala Leu Gly Phe 
    370                 375                 380                 


Gly Phe Leu Ser Val Gln Ile Leu Ser Leu Ile Gln Lys Met Arg Pro 
385                 390                 395                 400 


Leu Lys Glu Thr Arg Lys Leu Arg Ile Phe Phe Tyr Gly Ile Phe Pro 
                405                 410                 415     


Leu Phe Val Leu Val Leu Gly Ala Tyr Phe Tyr Phe Ser Gln Ser Ala 
            420                 425                 430         


Ile Tyr Glu Ser Met Gly Val Glu Phe Gln Lys Asn Phe Val Ser Phe 
        435                 440                 445             


Phe Val Glu Asp Thr Leu Leu Phe Ser Leu Leu Ile Leu Ala Ile Phe 
    450                 455                 460                 


Thr Pro Leu Ile Phe Glu Leu Leu Trp Arg Lys Lys Asp Ile Arg Phe 
465                 470                 475                 480 


Val Cys Ser Phe Tyr Ile Val Gly Val Leu Leu Phe Ser Leu Trp Ala 
                485                 490                 495     


Asn Leu Ser His Ile Tyr Asn Tyr Arg Ala His Thr Val Phe Ser Tyr 
            500                 505                 510         


Asn Glu Ala Ser Ile Leu Asp Asn Leu Lys Ala Asn Val Ser Arg Glu 
        515                 520                 525             


Asp Tyr Ile Val Ala Trp Trp Asp Tyr Gly Tyr Pro Ile Arg Tyr Tyr 
    530                 535                 540                 


Ser Asp Val Lys Thr Leu Ala Asp Gly Gly Lys His Leu Gly Lys Asp 
545                 550                 555                 560 


Asn Phe Phe Pro Ser Phe Val Leu Ser Gln Asn Pro Arg Ala Ala Ala 
                565                 570                 575     


Asn Met Ala Arg Leu Ser Val Glu Tyr Thr Glu Lys Gly Phe Lys Thr 
            580                 585                 590         


Pro Tyr Asn Asp Leu Leu Glu Ala Met Met Lys Asp Tyr Asn Tyr Ser 
        595                 600                 605             


Asn Val Asn Leu Phe Leu Ala Ala Leu Ser Lys Glu Asp Phe Thr Leu 
    610                 615                 620                 


Gln Thr Pro Lys Thr Arg Asp Ile Tyr Ile Tyr Met Pro Ser Arg Met 
625                 630                 635                 640 


Ala Ala Ile Phe Gly Thr Val Ala Ser Phe Ser Tyr Met Ser Leu Glu 
                645                 650                 655     


Thr Gly Glu Leu Glu Asn Pro Phe Val Tyr Ser Val Ala Tyr Tyr Leu 
            660                 665                 670         


Gly Asn Glu Asp Gly Lys Leu Val Leu Ser Asn Asn Met Leu Leu His 
        675                 680                 685             


Ser Asp Phe Arg Ser Phe Asp Leu Asn Gly Lys Asn Tyr Ala Ile Asn 
    690                 695                 700                 


Ser Leu Val Glu Phe Thr Ser Val Gln Gln Lys Tyr Tyr Ser Val Val 
705                 710                 715                 720 


Glu Ile Asp Lys Asn Ala Lys Tyr Tyr Leu Phe His Ile Lys Asp Ala 
                725                 730                 735     


Asn Ile Pro Asn Val Gln Phe Ile Leu Met Asp Lys Ala Met Tyr Glu 
            740                 745                 750         


Ser Ala Phe Val Gln Met Phe Phe Phe Gly Lys Tyr Asp Glu Ser Leu 
        755                 760                 765             


Tyr Glu Leu Ile Val Asp Ser Lys Glu Ala Lys Val Tyr Lys Leu Lys 
    770                 775                 780                 


Leu 
785 


<210>  9
<211>  2358
<212>  DNA
<213>  Campylobacter upsaliensis

<400>  9
atgaaaaacg aggctgtgaa aaatgcgaat ttgaggctag tattttttat cttactagct       60

tttggtttta gtgttttatg tcgcttttat tggatttatt gggcgagtga ttttaacgaa      120

tattttttta ataatcagct tatgataagc tcaaatgacg gctacacttt tgcagagggt      180

gctagagata agatagcggg ctttcatcag gaaaatgatt taagctttat taattcctct      240

ctttctattt tgacttatgt gctttataaa atcacgcctt ttagttttga aagcattatt      300

ttatatatga gtgtattttt ttcttcactt atagttgtgc cgcttatttt aattgcaaat      360

gagcttaaac gccctttaat gggacttttt gcggcatttt tagcaagtat tgcaaaaagc      420

tattataacc gcactatggc aggatattat gatacagata tgttagccat tgtgcttcct      480

atgtttattt tatatttttt catcaggctt attttaagaa aagatgattt ttctttactt      540

gccttgccgt tttttatggg actttatctt tggtggtatc catcaagcta tactctaaat      600

gtcgctttta tcgcactttt taccctttat gttttgattt atcatagaaa agaaaggtct      660

ttttatatgg cagcactttt gtgtgccatt accctttcaa atattgcttg gttttatcaa      720

agtgctatta ttgttttact ttttgctctt tttatgctta aaaattcgtt ttttaatttt      780

aaatttatcg cacttttagc cttaggagtt ttagtttttt tggctttaag tggggggata      840

gaccccatac tttatcagct taaattttat cttttaagaa gtgatgaaag tgcaagttta      900

gcgcgtggtt ttgcgtattt taatgtaaat ttaaccatac aagaggttga aagtatcgat      960

ttaagcactt ttatgcaaag aattagcgga agtgagcttg tgtttttact ttctcttttt     1020

ggctttttat ggcttttaaa aaagcataag gtgatgcttt taaccctacc tatgcttttg     1080

ctcggttttt tagcacttag aggtgggctt agatttacta tttatgctgt gcctattatg     1140

gcgcttggct ttggcttttt aagcgttcaa attttaagct taatccaaaa aatgcgtccc     1200

ttaaaagaaa ctcgaaaatt aagaatattt ttttatggaa tctttccgct ttttgtgctt     1260

gttttggggg cttattttta ttttagtcaa agtgctattt atgagagtat gggagtggaa     1320

tttcaaaaga actttgtgag cttttttgta gaagatactt tgcttttttc tttgctgatt     1380

ttggctattt ttacgccttt aatttttgag cttttgtgga gaaaaaagga cattcgtttt     1440

gtgtgtagct tttatattgt gggggttttg cttttttctt tatgggcaaa tttaagtcat     1500

atttataatt atagagcaca caccgttttt agctacaatg aagcgagtat tttggataat     1560

cttaaagcta atgtttctag ggaagattat attgtggctt ggtgggatta tggctatcct     1620

attcgttatt atagcgatgt gaaaacctta gctgatgggg gtaagcattt gggtaaggat     1680

aattttttcc cttcttttgt tttaagtcaa aatccacgcg cagcggcaaa tatggcaaga     1740

cttagcgtag aatacacaga aaaaggcttt aaaacgcctt ataatgatct tttagaagcg     1800

atgatgaagg attataatta tagcaatgta aatttatttt tagcggcact ttctaaggag     1860

gattttactc ttcaaacgcc caaaactaga gatatttaca tctatatgcc ttctcgtatg     1920

gcggcgattt ttggcacggt ggcaagtttt tcttatatga gcttagaaac gggtgagctt     1980

gaaaatcctt ttgtttatag tgtggcgtat tatttgggaa atgaggacgg caaactcgtc     2040

ttaagtaata atatgctcct tcatagcgac tttagaagct ttgaccttaa tggcaagaat     2100

tatgctatta attctttggt tgaatttact tcggtgcagc aaaaatatta tagtgttgtg     2160

gagattgata aaaatgctaa atattatctc tttcacatca aagacgctaa tatccctaat     2220

gtgcaattta tcctaatgga taaggcgatg tatgagagtg ctttcgtgca aatgtttttc     2280

tttggtaagt atgatgagag tttgtatgaa ttaattgtag atagtaaaga agcaaaggtg     2340

tataaattaa aattatga                                                   2358


<210>  10
<211>  661
<212>  PRT
<213>  Artificial

<220>
<223>  Campylobacter Pg1B Consensus Sequence


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(60)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(78)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(81)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(108)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (115)..(124)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (127)..(129)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (131)..(133)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (135)..(135)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (137)..(139)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (149)..(149)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(156)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (159)..(160)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (162)..(162)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (164)..(165)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (170)..(172)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (174)..(177)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (179)..(182)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (185)..(186)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (189)..(189)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (191)..(194)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (200)..(201)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (203)..(210)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (212)..(216)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (218)..(224)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (226)..(226)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (231)..(231)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (234)..(234)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (242)..(250)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (252)..(255)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (257)..(257)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (263)..(263)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (266)..(266)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (269)..(271)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (273)..(275)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (282)..(282)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (284)..(285)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (288)..(289)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (291)..(292)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (295)..(296)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (298)..(301)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (303)..(303)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (305)..(307)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (310)..(310)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (312)..(312)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (316)..(316)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (319)..(320)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (328)..(328)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (331)..(332)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (338)..(348)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (350)..(373)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (376)..(377)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (379)..(381)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (385)..(387)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (390)..(391)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (393)..(394)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (397)..(400)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (405)..(405)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (407)..(407)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (415)..(415)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (421)..(421)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (425)..(425)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (438)..(438)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (441)..(441)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (444)..(448)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (463)..(463)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (465)..(469)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (471)..(471)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (473)..(473)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (475)..(476)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (481)..(486)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (489)..(490)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (492)..(494)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (497)..(499)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (501)..(501)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (506)..(506)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (508)..(508)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (512)..(512)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (515)..(516)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (518)..(520)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (523)..(523)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (525)..(531)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (533)..(540)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (542)..(542)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (544)..(552)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (554)..(556)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (558)..(558)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (560)..(565)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (569)..(586)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (588)..(601)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (603)..(604)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (606)..(618)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (620)..(622)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (624)..(628)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (630)..(632)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (636)..(639)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (642)..(643)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (645)..(653)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (656)..(661)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Xaa Xaa Asn Asp Gly Tyr Xaa Phe Ala Glu Gly Ala Arg Asp Xaa Ile 
1               5                   10                  15      


Ala Gly Phe His Gln Xaa Asn Asp Leu Ser Xaa Xaa Xaa Ser Ser Leu 
            20                  25                  30          


Ser Xaa Leu Thr Tyr Xaa Xaa Tyr Xaa Ile Leu Pro Phe Ser Xaa Glu 
        35                  40                  45              


Ser Ile Xaa Xaa Tyr Xaa Ser Xaa Phe Xaa Xaa Xaa Leu Xaa Val Xaa 
    50                  55                  60                  


Pro Xaa Ile Leu Xaa Ala Xaa Glu Xaa Lys Xaa Xaa Xaa Xaa Gly Xaa 
65                  70                  75                  80  


Xaa Ala Ala Xaa Leu Xaa Ser Ile Ala Xaa Ser Tyr Tyr Asn Arg Thr 
                85                  90                  95      


Met Xaa Gly Tyr Tyr Asp Thr Asp Met Leu Xaa Xaa Val Leu Xaa Met 
            100                 105                 110         


Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Asp Xaa Xaa 
        115                 120                 125             


Xaa Leu Xaa Xaa Xaa Pro Xaa Phe Xaa Xaa Xaa Tyr Leu Trp Trp Tyr 
    130                 135                 140                 


Pro Ser Ser Tyr Xaa Leu Asn Xaa Ala Xaa Xaa Xaa Leu Phe Xaa Xaa 
145                 150                 155                 160 


Tyr Xaa Leu Xaa Xaa His Xaa Lys Glu Xaa Xaa Xaa Tyr Xaa Xaa Xaa 
                165                 170                 175     


Xaa Leu Xaa Xaa Xaa Xaa Leu Ser Xaa Xaa Ala Trp Xaa Tyr Xaa Xaa 
            180                 185                 190         


Xaa Xaa Ile Val Xaa Leu Phe Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Leu Xaa Leu Ser Gly Gly Xaa Asp Pro Xaa Leu Tyr Gln Leu Lys Xaa 
225                 230                 235                 240 


Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Phe 
                245                 250                 255     


Xaa Tyr Phe Asn Val Asn Xaa Thr Ile Xaa Glu Val Xaa Xaa Xaa Asp 
            260                 265                 270         


Xaa Xaa Xaa Phe Met Xaa Arg Ile Ser Xaa Ser Xaa Xaa Val Phe Xaa 
        275                 280                 285             


Xaa Ser Xaa Xaa Gly Phe Xaa Xaa Leu Xaa Xaa Xaa Xaa Lys Xaa Met 
    290                 295                 300                 


Xaa Xaa Xaa Leu Pro Xaa Leu Xaa Leu Gly Phe Xaa Ala Leu Xaa Xaa 
305                 310                 315                 320 


Gly Leu Arg Phe Thr Ile Tyr Xaa Val Pro Xaa Xaa Ala Leu Gly Phe 
                325                 330                 335     


Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa His Ile Xaa Xaa Tyr Xaa Xaa Xaa Thr Val Phe 
    370                 375                 380                 


Xaa Xaa Xaa Glu Ala Xaa Xaa Leu Xaa Xaa Leu Lys Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Arg Glu Asp Tyr Xaa Val Xaa Trp Trp Asp Tyr Gly Tyr Pro Xaa Arg 
                405                 410                 415     


Tyr Tyr Ser Asp Xaa Lys Thr Leu Xaa Asp Gly Gly Lys His Leu Gly 
            420                 425                 430         


Lys Asp Asn Phe Phe Xaa Ser Phe Xaa Leu Ser Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Ala Ala Asn Met Ala Arg Leu Ser Val Glu Tyr Thr Glu Lys Xaa Phe 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Asp Xaa Leu Xaa Ala Xaa Xaa Lys Asp Tyr Asn 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Phe Leu Xaa Xaa Leu Xaa Xaa Xaa Asp Phe 
                485                 490                 495     


Xaa Xaa Xaa Thr Xaa Lys Thr Arg Asp Xaa Tyr Xaa Tyr Met Pro Xaa 
            500                 505                 510         


Arg Met Xaa Xaa Ile Xaa Xaa Xaa Val Ala Xaa Phe Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Ala Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Leu Xaa Asn Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Asp Phe Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Tyr Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Asp Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Gln Met Phe Xaa Xaa Xaa Xaa Tyr 
625                 630                 635                 640 


Asp Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Lys Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa 
            660     


<210>  11
<211>  967
<212>  PRT
<213>  Pyrococcus furiosus

<400>  11

Met Val Lys Thr Gln Ile Lys Glu Lys Lys Lys Asp Glu Lys Val Thr 
1               5                   10                  15      


Ile Pro Leu Pro Gly Lys Ile Lys Thr Val Leu Ala Phe Leu Val Val 
            20                  25                  30          


Leu Ala Phe Ala Ala Tyr Gly Phe Tyr Ile Arg His Leu Thr Ala Gly 
        35                  40                  45              


Lys Tyr Phe Ser Asp Pro Asp Thr Phe Tyr His Phe Glu Ile Tyr Lys 
    50                  55                  60                  


Leu Val Leu Lys Glu Gly Leu Pro Arg Tyr Tyr Pro Met Ala Asp Ala 
65                  70                  75                  80  


Pro Phe Gly Ser Leu Ile Gly Glu Pro Leu Gly Leu Tyr Ile Leu Pro 
                85                  90                  95      


Ala Ile Phe Tyr Lys Ile Ile Ser Ile Phe Gly Tyr Asn Glu Leu Glu 
            100                 105                 110         


Ala Phe Leu Leu Trp Pro Pro Phe Val Gly Phe Leu Ser Val Ile Gly 
        115                 120                 125             


Val Tyr Leu Leu Gly Arg Lys Val Leu Asn Glu Trp Ala Gly Met Trp 
    130                 135                 140                 


Gly Ala Ile Ile Leu Ser Val Leu Thr Ala Asn Phe Ser Arg Thr Phe 
145                 150                 155                 160 


Ser Gly Asn Ala Arg Gly Asp Gly Pro Phe Met Met Leu Phe Thr Phe 
                165                 170                 175     


Ser Ala Val Leu Met Leu Tyr Tyr Leu Thr Glu Glu Asn Lys Asn Lys 
            180                 185                 190         


Lys Ile Ile Trp Gly Thr Leu Phe Val Leu Leu Ala Gly Ile Ser Thr 
        195                 200                 205             


Ala Ala Trp Asn Gly Ser Pro Phe Gly Leu Met Val Leu Leu Gly Phe 
    210                 215                 220                 


Ala Ser Phe Gln Thr Ile Ile Leu Phe Ile Phe Gly Lys Ile Asn Glu 
225                 230                 235                 240 


Leu Arg Glu Phe Ile Lys Glu Tyr Tyr Pro Ala Tyr Leu Gly Ile Leu 
                245                 250                 255     


Ala Ile Ser Tyr Leu Leu Thr Ile Pro Gly Ile Gly Lys Ile Gly Gly 
            260                 265                 270         


Phe Val Arg Phe Ala Phe Glu Val Phe Leu Gly Leu Val Phe Leu Ala 
        275                 280                 285             


Ile Val Met Leu Tyr Gly Gly Lys Tyr Leu Asn Tyr Ser Asp Lys Lys 
    290                 295                 300                 


His Arg Phe Ala Val Val Ala Val Ile Val Ile Ala Gly Phe Ala Gly 
305                 310                 315                 320 


Ala Tyr Ile Tyr Val Gly Pro Lys Leu Phe Thr Leu Met Gly Gly Ala 
                325                 330                 335     


Tyr Gln Ser Thr Gln Val Tyr Glu Thr Val Gln Glu Leu Ala Lys Thr 
            340                 345                 350         


Asp Trp Gly Asp Val Lys Val Tyr Tyr Gly Val Glu Lys Pro Asn Gly 
        355                 360                 365             


Ile Val Phe Phe Leu Gly Leu Val Gly Ala Met Ile Val Thr Ala Arg 
    370                 375                 380                 


Tyr Leu Tyr Lys Leu Phe Lys Asp Gly Arg Arg Pro His Glu Glu Leu 
385                 390                 395                 400 


Phe Ala Ile Thr Phe Tyr Val Met Ser Ile Tyr Leu Leu Trp Thr Ala 
                405                 410                 415     


Ala Arg Phe Leu Phe Leu Ala Ser Tyr Ala Ile Ala Leu Met Ser Gly 
            420                 425                 430         


Val Phe Ala Gly Tyr Val Leu Glu Thr Val Glu Lys Met Lys Glu Ser 
        435                 440                 445             


Ile Pro Ile Lys Ala Ala Leu Gly Gly Val Ile Ala Ile Met Leu Leu 
    450                 455                 460                 


Leu Ile Pro Leu Thr His Gly Pro Leu Leu Ala Gln Ser Ala Lys Ser 
465                 470                 475                 480 


Met Arg Thr Thr Glu Ile Glu Thr Ser Gly Trp Glu Asp Ala Leu Lys 
                485                 490                 495     


Trp Leu Arg Glu Asn Thr Pro Glu Tyr Ser Thr Ala Thr Ser Trp Trp 
            500                 505                 510         


Asp Tyr Gly Tyr Trp Ile Glu Ser Ser Leu Leu Gly Gln Arg Arg Ala 
        515                 520                 525             


Ser Ala Asp Gly Gly His Ala Arg Asp Arg Asp His Ile Leu Ala Leu 
    530                 535                 540                 


Phe Leu Ala Arg Asp Gly Asn Ile Ser Glu Val Asp Phe Glu Ser Trp 
545                 550                 555                 560 


Glu Leu Asn Tyr Phe Leu Val Tyr Leu Asn Asp Trp Ala Lys Phe Asn 
                565                 570                 575     


Ala Ile Ser Tyr Leu Gly Gly Ala Ile Thr Arg Arg Glu Tyr Asn Gly 
            580                 585                 590         


Asp Glu Ser Gly Arg Gly Ala Val Thr Thr Leu Leu Pro Leu Pro Arg 
        595                 600                 605             


Tyr Gly Glu Lys Tyr Val Asn Leu Tyr Ala Lys Val Ile Val Asp Val 
    610                 615                 620                 


Ser Asn Ser Ser Val Lys Val Thr Val Gly Asp Arg Glu Cys Asp Pro 
625                 630                 635                 640 


Leu Met Val Thr Phe Thr Pro Ser Gly Lys Thr Ile Lys Gly Thr Gly 
                645                 650                 655     


Thr Cys Ser Asp Gly Asn Ala Phe Pro Tyr Val Leu His Leu Thr Pro 
            660                 665                 670         


Thr Ile Gly Val Leu Ala Tyr Tyr Lys Val Ala Thr Ala Asn Phe Ile 
        675                 680                 685             


Lys Leu Ala Phe Gly Val Pro Ala Ser Thr Ile Pro Gly Phe Ser Asp 
    690                 695                 700                 


Lys Leu Phe Ser Asn Phe Glu Pro Val Tyr Glu Ser Gly Asn Val Ile 
705                 710                 715                 720 


Val Tyr Arg Phe Thr Pro Phe Gly Ile Tyr Lys Ile Glu Glu Asn Ile 
                725                 730                 735     


Asn Gly Thr Trp Lys Gln Val Tyr Asn Leu Thr Pro Gly Lys His Glu 
            740                 745                 750         


Leu Lys Leu Tyr Ile Ser Ala Phe Gly Arg Asp Ile Glu Asn Ala Thr 
        755                 760                 765             


Leu Tyr Ile Tyr Ala Ile Asn Asn Glu Lys Ile Ile Glu Lys Ile Lys 
    770                 775                 780                 


Ile Ala Glu Ile Ser His Met Asp Tyr Leu Asn Glu Tyr Pro Ile Ala 
785                 790                 795                 800 


Val Asn Val Thr Leu Pro Asn Ala Thr Ser Tyr Arg Phe Val Leu Val 
                805                 810                 815     


Gln Lys Gly Pro Ile Gly Val Leu Leu Asp Ala Pro Lys Val Asn Gly 
            820                 825                 830         


Glu Ile Arg Ser Pro Thr Asn Ile Leu Arg Glu Gly Glu Ser Gly Glu 
        835                 840                 845             


Ile Glu Leu Lys Val Gly Val Asp Lys Asp Tyr Thr Ala Asp Leu Tyr 
    850                 855                 860                 


Leu Arg Ala Thr Phe Ile Tyr Leu Val Arg Lys Ser Gly Lys Asp Asn 
865                 870                 875                 880 


Glu Asp Tyr Asp Ala Ala Phe Glu Pro Gln Met Asp Val Phe Phe Ile 
                885                 890                 895     


Thr Lys Ile Gly Glu Asn Ile Gln Leu Lys Glu Gly Glu Asn Thr Val 
            900                 905                 910         


Lys Val Arg Ala Glu Leu Pro Glu Gly Val Ile Ser Ser Tyr Lys Asp 
        915                 920                 925             


Glu Leu Gln Arg Lys Tyr Gly Asp Lys Leu Ile Ile Arg Gly Ile Arg 
    930                 935                 940                 


Val Glu Pro Val Phe Ile Ala Glu Lys Glu Tyr Leu Met Leu Glu Val 
945                 950                 955                 960 


Ser Ala Ser Ala Pro His His 
                965         


<210>  12
<211>  2904
<212>  DNA
<213>  Pyrococcus furiosus

<400>  12
atggtgaaaa cccaaataaa ggagaaaaag aaagatgaaa aagttactat tccacttcct       60

gggaagataa aaactgtttt ggccttccta gtcgttttgg catttgccgc atatggattt      120

tacattagac atttaacagc cggaaagtat ttctcagatc cagatacctt ctaccatttc      180

gaaatttata agctagtcct caaagagggc cttcctaggt attacccaat ggcagatgct      240

ccatttggaa gtctcatagg agaacctctt ggactataca tccttccagc aatattctac      300

aaaataatct caatatttgg gtacaatgag ctagaggcat ttcttctttg gcccccattc      360

gtaggatttc tcagtgttat aggtgtttac ttactcggaa gaaaagttct gaacgaatgg      420

gcagggatgt ggggtgctat aattctctca gtcctcacgg caaacttttc aagaacattc      480

tcaggcaacg caagaggcga cggcccattc atgatgttgt ttacgttttc agcagtccta      540

atgctctatt atctaaccga ggaaaataaa aacaagaaaa taatctgggg aacactgttt      600

gtactcttgg caggaatatc aactgcagca tggaacggtt caccatttgg actaatggtt      660

ctccttggat tcgcatcgtt ccagacaata atcctcttta tttttggaaa gatcaatgag      720

cttagagaat tcataaagga atactaccca gcatacctgg gaattttagc tataagctac      780

cttctaacga tcccaggaat tggaaaaata ggaggatttg taagatttgc atttgaggtt      840

ttcttagggt tagttttctt agccatcgtc atgctctatg gaggaaaata cttgaactat      900

tctgacaaga agcacaggtt cgcagtggtt gcagttatag ttattgcggg gttcgcagga      960

gcttatattt acgttggtcc aaaactcttc actctaatgg gtggagctta tcagtcaacg     1020

caagtttatg aaacagtaca ggagctcgca aaaactgatt ggggagatgt aaaagtctat     1080

tatggagtag aaaagccaaa cggaatagtc ttcttccttg gattagttgg agcaatgatt     1140

gttacagcta ggtacctcta caaattattt aaagatggaa ggcgcccaca cgaagagtta     1200

tttgcaataa ctttctatgt aatgtcaatt tacctcctct ggacagctgc tagattccta     1260

ttcctagcga gttatgcgat agcattgatg tcaggtgtct ttgcaggata cgtcctagag     1320

actgtagaaa agatgaaaga gagtatacca ataaaagcag cactaggagg agtaattgct     1380

attatgcttc ttctaatacc cttaactcat ggcccactct tagctcaaag cgctaaaagt     1440

atgagaacaa ccgagatcga gactagtgga tgggaagatg cgctcaaatg gctcagagaa     1500

aacactccag aatattcgac cgcaacctct tggtgggact atggatattg gatagagtca     1560

agcctcctag gacagagaag ggccagtgct gatggtggac atgcaagaga tagagatcat     1620

atcttagccc tatttctagc cagagacggt aacattagtg aagtagactt tgagagttgg     1680

gagcttaact acttcctagt ttaccttaat gattgggcaa agttcaatgc aatcagctat     1740

ctaggcgggg ctataacgag gagagaatac aatggagatg aaagtggaag aggagccgta     1800

actacgctac ttcctctccc aaggtatgga gagaaatacg tcaacctcta tgccaaagtt     1860

atagttgatg tttcaaactc gagcgtaaag gttactgtag gagacagaga gtgtgatcca     1920

ctaatggtta cgtttactcc aagtggaaag acgataaaag gaactggaac ctgtagtgat     1980

ggcaacgcct tcccatatgt tttacactta actccaacaa ttggagtact tgcatactac     2040

aaagtagcaa ctgcaaactt cattaagtta gccttcggtg ttccagcttc aacaattcca     2100

ggattctctg ataagctatt ctcaaacttt gagccagtgt atgagtcagg aaacgtaata     2160

gtatatcgct tcacaccatt tggaatatac aaaattgagg aaaacattaa cggaacttgg     2220

aagcaagttt ataacctaac tcctggaaaa cacgagctca aactgtacat ttcagcattc     2280

ggaagagaca tcgaaaatgc aacgctgtac atttacgcca taaacaacga gaagatcata     2340

gagaaaatta agattgccga gatatcccac atggactatc taaatgaata cccgatagca     2400

gtgaacgtaa ccctaccaaa tgctacaagc tacaggtttg tactagttca aaaaggccca     2460

ataggtgttc ttctagatgc accaaaagtc aatggtgaga taagaagtcc aaccaacata     2520

ctaagggaag gagaaagtgg agaaatagag cttaaagttg gggttgataa agactacact     2580

gccgatctat acttaagggc tacgttcata tatttagtca gaaaaagtgg aaaggataac     2640

gaagattatg acgcagcgtt tgagccccaa atggatgttt tctttatcac aaagatcgga     2700

gaaaacattc aacttaaaga aggagagaat acagtaaagg ttagggcgga gcttccagaa     2760

ggagttatat ctagctacaa agatgaacta cagagaaaat acggagacaa gttgataatc     2820

agaggaataa gagtagagcc agtgttcata gcagaaaaag agtacctaat gctcgaggtc     2880

agtgcatcgg ctcctcatca ctaa                                            2904


<210>  13
<211>  980
<212>  PRT
<213>  Artificial

<220>
<223>  Pyrococcus sp. ST04 OST

<400>  13

Met Lys Ser Leu Val Lys Val Glu Val Lys Arg Glu Lys Lys Asp Arg 
1               5                   10                  15      


Lys Glu Lys Arg Glu Ile Gly Asn Ile Ser Arg His Tyr Gly Lys Ile 
            20                  25                  30          


Lys Leu Ala Leu Thr Phe Ile Val Thr Leu Ile Phe Ala Trp Tyr Ala 
        35                  40                  45              


Phe His Ile Arg His Leu Thr Ala Gly Lys Tyr Phe Pro Asp Pro Asp 
    50                  55                  60                  


Thr Phe Tyr His Tyr Glu Ile Tyr Lys Leu Val Leu Lys Glu Gly Leu 
65                  70                  75                  80  


Pro Lys Tyr Tyr Pro Met Ser Asp Ala Pro Phe Gly Ser Leu Ile Gly 
                85                  90                  95      


Glu Pro Leu Gly Leu Tyr Ile Leu Pro Ala Ile Phe Tyr Lys Ile Leu 
            100                 105                 110         


Ser Ala Phe Gly Tyr Asn Glu Phe Gln Ala Phe Leu Leu Trp Pro Pro 
        115                 120                 125             


Phe Val Gly Phe Leu Ser Val Ile Gly Val Tyr Leu Leu Gly Arg Lys 
    130                 135                 140                 


Ile Leu Asn Glu Trp Ala Gly Leu Trp Ala Ala Ala Ile Leu Ala Val 
145                 150                 155                 160 


Ser Thr Ala Asn Phe Ser Arg Thr Phe Ser Gly Asn Ala Arg Gly Asp 
                165                 170                 175     


Gly Pro Phe Met Met Leu Phe Val Phe Ser Met Val Ala Leu Leu Tyr 
            180                 185                 190         


Tyr Leu Glu Glu Ala Arg Ile Lys Arg Lys Ala Val Trp Gly Ala Leu 
        195                 200                 205             


Phe Val Ile Leu Ala Gly Leu Ser Thr Met Ala Trp Asn Gly Ser Pro 
    210                 215                 220                 


Phe Gly Leu Met Val Leu Leu Gly Phe Ala Ser Leu Gln Thr Ile Ala 
225                 230                 235                 240 


Leu Phe Ile Phe Gly Lys Ile Asp Glu Leu Lys Lys Phe Ile Lys Glu 
                245                 250                 255     


Phe Tyr Pro Ala Tyr Val Ser Val Leu Ile Leu Ser Tyr Leu Leu Thr 
            260                 265                 270         


Ile Pro Gly Leu Ala Lys Ile Gln Ser Phe Ile Arg Phe Ala Phe Glu 
        275                 280                 285             


Val Phe Leu Gly Leu Val Phe Leu Ala Ile Val Met Leu Tyr Gly Glu 
    290                 295                 300                 


Lys Phe Leu Asn Tyr Ser Asp Lys Lys His Arg Phe Leu Val Val Ala 
305                 310                 315                 320 


Ile Ile Val Leu Ile Gly Phe Ala Gly Ala Tyr Ala Tyr Val Gly Pro 
                325                 330                 335     


Lys Leu Phe Arg Leu Met Gly Gly Ala Tyr Gln Ser Thr Gln Val Tyr 
            340                 345                 350         


Gln Thr Val Gln Glu Leu Ala Lys Thr Ser Met Gln Asp Ile Lys Leu 
        355                 360                 365             


Tyr Tyr Gly Val Glu Lys Ala Asn Gly Leu Ile Phe Phe Leu Ser Ile 
    370                 375                 380                 


Pro Gly Phe Leu Ile Met Leu Ser Leu Tyr Leu Ile Gly Leu Trp Ser 
385                 390                 395                 400 


Lys Ser Glu Ser Pro Asn Lys Glu Leu Leu Gly Ile Thr Phe Tyr Val 
                405                 410                 415     


Met Ser Ile Tyr Leu Met Ser Leu Ala Val Arg Phe Leu Phe Leu Ala 
            420                 425                 430         


Ser Tyr Ala Ile Ala Leu Phe Ala Gly Ile Leu Val Gly Tyr Gly Leu 
        435                 440                 445             


Glu Val Ile Glu Lys Met Lys Glu Asn Val Gly Ile Lys Ala Ala Leu 
    450                 455                 460                 


Ala Ile Val Ile Ser Ile Met Ile Leu Leu Ile Pro Ile Thr His Gly 
465                 470                 475                 480 


Pro Val Leu Ala Arg Ser Ala Lys Ala Met Ser Lys Thr Glu Val Glu 
                485                 490                 495     


Thr Ser Gly Trp Glu Gln Ala Leu Lys Trp Leu Arg Asn Asn Thr Pro 
            500                 505                 510         


Lys Tyr Ala Thr Ala Thr Ser Trp Trp Asp Tyr Gly Tyr Trp Ile Glu 
        515                 520                 525             


Ser Ser Leu Leu Gly Asn Arg Arg Ala Ser Ala Asp Gly Gly His Ala 
    530                 535                 540                 


Arg Asp Arg Asp His Ile Leu Ala Leu Phe Leu Ala Arg Asp Gly Asn 
545                 550                 555                 560 


Val Ser Glu Val Asp Phe Glu Ser Trp Glu Leu Asn Tyr Phe Ile Val 
                565                 570                 575     


Tyr Leu Asn Asp Trp Ala Lys Phe Asn Ala Ile Ser Tyr Leu Gly Gly 
            580                 585                 590         


Ala Ile Thr Lys Arg Glu Tyr Ser Gly Asp Glu Lys Gly Arg Gly Ser 
        595                 600                 605             


Ile Pro Thr Ile Ile Leu Ala Pro Arg Phe Gly Glu Gln Tyr Ile Asn 
    610                 615                 620                 


Pro Tyr Asn Gly Val Ser Ile Lys Val Leu Asn Asn Ser Gln Val Thr 
625                 630                 635                 640 


Val Thr Ile Gly Ser Thr Thr Cys Ser Pro Leu Met Thr Val Phe Ile 
                645                 650                 655     


Pro Gly Asn Lys Lys Val Lys Gly Gln Gly Ser Cys Thr Asn Gly Gly 
            660                 665                 670         


Ser Phe Pro Phe Val Val Tyr Leu Thr Pro Thr Leu Gly Val Ile Ser 
        675                 680                 685             


Tyr Tyr Lys Val Ala Thr Ser Asn Phe Leu Lys Leu Ala Tyr Gly Ile 
    690                 695                 700                 


Pro Ala Ser Lys Glu Pro Gly Phe Thr Asp Lys Leu Phe Ser Asn Phe 
705                 710                 715                 720 


Lys Met Val Tyr Gln Glu Gly Asn Val Val Ile Tyr Glu Phe Arg Pro 
                725                 730                 735     


Phe Ala Ile Tyr Lys Leu Gln Glu Phe Thr Asn Gly Thr Trp Lys Thr 
            740                 745                 750         


Ile Thr Thr Leu Ser Pro Gly Lys His Thr Leu Lys Leu Tyr Ile Ser 
        755                 760                 765             


Ala Phe Gly Arg Asp Ile Lys Asn Ala Thr Leu Tyr Ile Asp Ala Ile 
    770                 775                 780                 


Lys Asp Asn Arg Thr Ile Gln Arg Ile Lys Ile Gly Glu Ile Lys Tyr 
785                 790                 795                 800 


Met Ser His Leu Asn Glu Thr Pro Ile Thr Val Asn Val Thr Leu Pro 
                805                 810                 815     


Asp Ala Asp Lys Tyr Lys Phe Val Leu Val Gln Lys Gly Pro Val Gly 
            820                 825                 830         


Val Leu Thr Ala Pro Pro Lys Val Asn Gly Lys Ile Ala Asn Pro Val 
        835                 840                 845             


Arg Val Leu Asn Asp Gly Glu Ser Gly Arg Leu Glu Leu Lys Val Gly 
    850                 855                 860                 


Val Asp Lys Asp Tyr Lys Ala Asp Leu Tyr Leu Arg Ala Thr Phe Ile 
865                 870                 875                 880 


Tyr Leu Val Arg Lys Ser Gly Thr Ser Asn Asp Asp Tyr Asn Ala Ala 
                885                 890                 895     


Phe Glu Pro His Met Asp Val Phe Phe Ile Thr Lys Leu Lys Ser Gly 
            900                 905                 910         


Ile Ser Leu His Lys Gly Glu Asn Glu Val Thr Val Glu Ala Lys Met 
        915                 920                 925             


Pro Glu Asn Val Ile Ser Asp Tyr Lys Lys Lys Leu Glu Ala Glu Tyr 
    930                 935                 940                 


Gly Asp Lys Leu Ile Ile Arg Gly Ile Arg Val Glu Pro Val Phe Ile 
945                 950                 955                 960 


Ala Glu Lys Glu Tyr Val Met Leu Glu Val Arg Ala Ser Ala Pro His 
                965                 970                 975     


His Ser Ser Glu 
            980 


<210>  14
<211>  973
<212>  PRT
<213>  Artificial

<220>
<223>  Pyrococcus strain NA2 OST

<400>  14

Met Val Lys Arg Lys Lys Glu Glu Lys Glu Ile Lys Gly Glu Lys Arg 
1               5                   10                  15      


Glu Phe Tyr Ser Lys Ile Lys Arg Met Ile Ile Pro Ile Ile Val Leu 
            20                  25                  30          


Gly Phe Ala Thr Tyr Gly Phe Tyr Leu Arg His Leu Thr Ala Gly Arg 
        35                  40                  45              


Tyr Phe Pro Asp Pro Asp Thr Phe Tyr His Phe Glu Ile Tyr Lys Leu 
    50                  55                  60                  


Val Ile Lys Glu Gly Leu Pro Lys Tyr Tyr Pro Leu Ser Asp Ala Pro 
65                  70                  75                  80  


Phe Gly Ser Leu Ile Gly Glu Pro Leu Gly Leu Tyr Ile Leu Pro Ala 
                85                  90                  95      


Ile Phe Tyr Lys Val Ile Ser Ala Phe Gly Tyr Asn Glu Phe Gln Ala 
            100                 105                 110         


Phe Leu Leu Trp Pro Pro Phe Val Gly Phe Leu Ser Val Val Gly Ile 
        115                 120                 125             


Tyr Leu Leu Gly Arg Lys Val Leu Asn Glu Trp Ala Gly Leu Trp Ala 
    130                 135                 140                 


Ala Val Ile Leu Ser Val Ser Thr Ala Asn Phe Ser Arg Thr Phe Ser 
145                 150                 155                 160 


Gly Asn Ala Arg Gly Asp Gly Pro Phe Met Met Leu Phe Val Phe Ser 
                165                 170                 175     


Ala Ile Leu Met Phe His Tyr Leu Arg Glu Thr Ser Lys Thr Lys Lys 
            180                 185                 190         


Val Leu Tyr Gly Thr Leu Phe Val Ile Leu Ala Ser Ile Ser Leu Gly 
        195                 200                 205             


Ala Trp Asn Gly Ser Pro Phe Gly Leu Met Val Leu Leu Gly Phe Ala 
    210                 215                 220                 


Ser Phe Gln Thr Ile Ala Leu Phe Ile Phe Gly Lys Ile Ser Glu Leu 
225                 230                 235                 240 


Lys Lys Phe Ala Thr Glu Phe Tyr Pro Ala Tyr Leu Gly Ile Leu Ala 
                245                 250                 255     


Leu Gly Tyr Leu Leu Thr Ile Pro Gly Ile Val Lys Ile Gly Ser Phe 
            260                 265                 270         


Ile Lys Phe Ala Phe Glu Val Phe Leu Gly Leu Val Val Leu Leu Thr 
        275                 280                 285             


Ile Met Leu Tyr Gly Gly Arg Tyr Leu Asn Tyr Ser Asp Lys Lys His 
    290                 295                 300                 


Arg Phe Leu Val Val Ala Val Val Val Leu Ile Gly Phe Ala Gly Ala 
305                 310                 315                 320 


Tyr Ala Tyr Val Gly Pro Lys Leu Phe Arg Leu Met Gly Gly Ala Tyr 
                325                 330                 335     


Gln Ser Thr Gln Val Tyr Glu Thr Val Gln Glu Leu Ala Lys Thr Thr 
            340                 345                 350         


Met Arg Asp Ile Lys Val Tyr Tyr Gly Val Glu Asn Pro Asn Gly Leu 
        355                 360                 365             


Ile Phe Phe Leu Ser Ile Pro Gly Ile Ile Ile Ile Leu Val Lys Tyr 
    370                 375                 380                 


Leu Val Asp Leu Phe Arg Lys Ser Glu Ser Ser Asn Glu Thr Leu Phe 
385                 390                 395                 400 


Ala Ala Val Phe Tyr Ile Met Ser Ile Tyr Leu Leu Ser Leu Ala Val 
                405                 410                 415     


Arg Phe Leu Phe Leu Ala Ser Tyr Ala Ile Ala Leu Phe Ala Gly Ile 
            420                 425                 430         


Phe Ala Gly Phe Val Ile Glu Ile Val Glu Lys Met Lys Glu Ser Ile 
        435                 440                 445             


Gly Ile Lys Ala Ala Leu Gly Ile Val Ile Ser Ile Met Ile Leu Met 
    450                 455                 460                 


Ile Pro Ile Thr His Ala Pro Val Leu Ala Arg Ser Ala Arg Ser Leu 
465                 470                 475                 480 


Ser Arg Thr Glu Val Glu Thr Thr Gly Trp Glu Gln Val Leu Lys Trp 
                485                 490                 495     


Leu Arg Ser Asn Thr Ser Gln Tyr Ala Thr Ala Thr Ser Trp Trp Asp 
            500                 505                 510         


Tyr Gly Tyr Trp Ile Glu Ser Ser Leu Leu Gly Asn Arg Arg Ala Ser 
        515                 520                 525             


Ala Asp Gly Gly His Ala Arg Asp Arg Asp His Ile Leu Ala Leu Phe 
    530                 535                 540                 


Leu Ala Arg Asp Gly Asn Val Ser Glu Val Asp Phe Glu Ser Trp Glu 
545                 550                 555                 560 


Leu Asn Tyr Phe Ile Val Tyr Leu Asn Asp Trp Ala Lys Phe Asn Ala 
                565                 570                 575     


Ile Ser Tyr Leu Gly Gly Ala Leu Thr Arg Arg Glu Tyr Lys Gly Asp 
            580                 585                 590         


Glu Thr Gly Arg Gly Ser Val Thr Ser Ile Leu Ile Thr Gln Gly Ala 
        595                 600                 605             


Gly Asn Val Tyr Val Asn Pro Tyr Ala Gly Ile Thr Ile Lys Val Val 
    610                 615                 620                 


Glu Glu Asn Lys Thr Arg Lys Val Val Val Asn Ile Gly Arg Leu Glu 
625                 630                 635                 640 


Cys Ser Pro Met Thr Thr Val Val Phe Pro Gly Asn Ile His Ile Lys 
                645                 650                 655     


Gly Thr Gly Ser Cys Asn Asn Gly Ser Ser Phe Pro Tyr Val Val Tyr 
            660                 665                 670         


Leu Thr Pro Ser Leu Gly Ile Ile Ala Tyr Tyr Lys Val Ala Thr Ser 
        675                 680                 685             


Asn Phe Ile Lys Leu Ala Phe Gly Ile Pro Val Ser Asn Tyr Lys Gly 
    690                 695                 700                 


Phe Thr Glu Lys Leu Phe Ser Asn Phe Val Pro Val Tyr Gln Ala Gly 
705                 710                 715                 720 


Asn Val Ile Val Tyr Glu Phe Arg Pro Phe Ala Ile Tyr Gly Met Glu 
                725                 730                 735     


Glu Leu Val Asn Gly Ser Trp Arg Tyr Ile Gly Tyr Leu Thr Pro Gly 
            740                 745                 750         


Lys His Thr Leu Arg Leu Tyr Ile Ser Ala Phe Gly Arg Asp Ile Lys 
        755                 760                 765             


Asn Ala Thr Leu Tyr Val Tyr Ala Ile Asn Gly Thr Glu Ile Thr Ala 
    770                 775                 780                 


Lys Ile Arg Leu Thr Lys Ile Asp Tyr Met Asn His Leu Asn Glu Tyr 
785                 790                 795                 800 


Pro Ile Thr Val Asn Val Thr Leu Pro Pro Ala Gln Lys Tyr Arg Phe 
                805                 810                 815     


Val Leu Val Gln Lys Gly Pro Val Gly Val Leu Thr Gly Pro Pro Lys 
            820                 825                 830         


Leu Asn Gly Lys Ile Val Asn Pro Ile Ser Val Leu Lys Glu Gly Glu 
        835                 840                 845             


Glu Gly Glu Leu Glu Leu Lys Val Gly Val Asp Lys Asn Tyr Thr Ala 
    850                 855                 860                 


Asp Leu Tyr Leu Arg Ala Thr Phe Ile Tyr Leu Val Arg Lys Gly Gly 
865                 870                 875                 880 


Thr Ser Asn Glu Asp Tyr Asn Ala Ala Phe Glu Pro His Met Asp Val 
                885                 890                 895     


Phe Phe Ile Ser Arg Val Lys Glu Gly Ile Lys Leu His Pro Gly Asp 
            900                 905                 910         


Asn Tyr Val Lys Ala His Val Glu Met Pro Lys Gly Val Ile Ser Ser 
        915                 920                 925             


Tyr Lys Glu Glu Leu Glu Lys Lys Tyr Gly Asp Arg Leu Ile Ile Arg 
    930                 935                 940                 


Gly Ile Arg Val Glu Pro Val Phe Ile Ala Glu Lys Glu Tyr Thr Met 
945                 950                 955                 960 


Leu Glu Val Ser Ala Ser Ala Pro His His Ser Ser Glu 
                965                 970             


<210>  15
<211>  976
<212>  PRT
<213>  Pyrococcus horikoshii

<400>  15

Met Val Lys Ser Lys Val Lys Lys Val Glu Lys Gly Lys Glu Gly Glu 
1               5                   10                  15      


Glu Lys Arg Ser Thr Tyr Val Leu Leu Lys Lys Val Leu Ile Pro Ile 
            20                  25                  30          


Leu Val Phe Gly Phe Ala Ile Tyr Ala Phe Tyr Leu Arg His Leu Thr 
        35                  40                  45              


Ala Gly Lys Tyr Phe Pro Asp Pro Asp Thr Phe Tyr His Phe Glu Ile 
    50                  55                  60                  


Tyr Lys Leu Val Leu Lys Glu Gly Leu Pro Arg Tyr Tyr Pro Met Ser 
65                  70                  75                  80  


Asp Ala Pro Phe Gly Ser Leu Ile Gly Glu Pro Leu Gly Leu Tyr Leu 
                85                  90                  95      


Leu Pro Ala Ala Phe Tyr Lys Val Val Ser Leu Phe Gly Tyr Asn Glu 
            100                 105                 110         


Leu Gln Ala Phe Leu Leu Trp Pro Pro Phe Val Gly Phe Leu Gly Val 
        115                 120                 125             


Ile Ala Val Tyr Leu Leu Gly Arg Lys Val Leu Asn Glu Trp Thr Gly 
    130                 135                 140                 


Leu Trp Gly Ala Val Val Leu Thr Val Ser Thr Ala Asn Phe Ser Arg 
145                 150                 155                 160 


Thr Phe Ser Gly Asn Ala Arg Gly Asp Gly Pro Phe Met Ala Leu Phe 
                165                 170                 175     


Ile Phe Ala Ser Val Ala Met Leu Tyr Tyr Leu Lys Glu Ser Asn Lys 
            180                 185                 190         


Thr Arg Lys Ile Ile Tyr Gly Thr Leu Phe Val Leu Leu Thr Val Ile 
        195                 200                 205             


Ser Leu Gly Ala Trp Asn Gly Ser Pro Phe Gly Leu Met Val Leu Leu 
    210                 215                 220                 


Gly Phe Ala Ser Leu Gln Thr Ile Ile Leu Phe Ile Phe Gly Lys Leu 
225                 230                 235                 240 


Glu Glu Leu Lys Lys Phe Val Lys Glu Phe Tyr Pro Ala Tyr Leu Ala 
                245                 250                 255     


Ile Leu Ala Phe Gly Tyr Ala Leu Thr Phe Pro Gly Ile Val Lys Ile 
            260                 265                 270         


Gly Gly Phe Ile Arg Phe Ala Phe Glu Val Phe Leu Gly Leu Ile Phe 
        275                 280                 285             


Leu Leu Val Ile Met Leu Tyr Gly Gly Arg Tyr Leu Asn Tyr Ser Asp 
    290                 295                 300                 


Lys Lys His Arg Phe Leu Val Val Thr Ile Ile Val Leu Leu Gly Phe 
305                 310                 315                 320 


Gly Gly Ala Tyr Ala Tyr Val Gly Pro Lys Leu Phe Arg Leu Met Gly 
                325                 330                 335     


Gly Ala Tyr Gln Ser Thr Gln Val Tyr Glu Thr Val Gln Glu Leu Ala 
            340                 345                 350         


Lys Thr Thr Ile Gly Asp Val Lys Ala Tyr Tyr Gly Val Glu Ser Gly 
        355                 360                 365             


Asn Gly Leu Ile Phe Phe Leu Ser Ile Pro Gly Leu Leu Ile Leu Leu 
    370                 375                 380                 


Thr Lys Tyr Leu Tyr Asp Leu Phe Lys Lys Ala Lys Ser Asp Asn Glu 
385                 390                 395                 400 


Thr Leu Phe Ala Leu Val Phe Tyr Thr Met Ser Leu Tyr Leu Leu Tyr 
                405                 410                 415     


Leu Ala Val Arg Phe Leu Phe Leu Ala Ser Tyr Ala Val Ala Leu Phe 
            420                 425                 430         


Phe Gly Ile Phe Ile Gly Phe Ser Met Asp Val Ile Glu Lys Met Lys 
        435                 440                 445             


Glu Asn Ile Gly Ile Lys Ala Ala Leu Gly Ile Val Leu Ser Leu Met 
    450                 455                 460                 


Ile Leu Val Ile Pro Phe Val His Ala Pro Val Leu Ala Arg Ser Ala 
465                 470                 475                 480 


Arg Ala Leu Lys Asn Thr Glu Ile Glu Val Thr Gly Trp Glu Gln Ala 
                485                 490                 495     


Leu Lys Trp Leu Arg Ser Asn Thr Ser Lys Tyr Ala Thr Ala Thr Ser 
            500                 505                 510         


Trp Trp Asp Tyr Gly Tyr Trp Ile Glu Ser Ser Leu Leu Gly Asn Arg 
        515                 520                 525             


Arg Ala Ser Ala Asp Gly Gly His Ala Arg Asp Arg Asp His Ile Leu 
    530                 535                 540                 


Ala Leu Phe Leu Ala Arg Asp Gly Asn Ile Ser Glu Val Asp Phe Glu 
545                 550                 555                 560 


Ser Trp Glu Leu Asn Tyr Phe Ile Ile Tyr Leu Asn Asp Trp Ala Lys 
                565                 570                 575     


Phe Asn Ala Ile Ser Tyr Leu Gly Gly Ala Ile Thr Arg Lys Glu Tyr 
            580                 585                 590         


Asn Gly Asp Glu Asn Gly Arg Gly Arg Val Thr Thr Ile Leu Leu Thr 
        595                 600                 605             


Gln Ala Ala Gly Asn Val Tyr Val Asn Pro Tyr Ala Arg Ile Val Ile 
    610                 615                 620                 


Lys Val Ile Gln Gln Asn Lys Thr Arg Arg Ile Ala Val Asn Ile Gly 
625                 630                 635                 640 


Gln Leu Glu Cys Ser Pro Ile Leu Ser Val Ala Phe Pro Gly Asn Ile 
                645                 650                 655     


Lys Ile Lys Gly Ser Gly Arg Cys Ser Asp Gly Ser Pro Phe Pro Tyr 
            660                 665                 670         


Val Val Tyr Leu Thr Pro Ser Leu Gly Val Leu Ala Tyr Tyr Lys Val 
        675                 680                 685             


Ala Thr Ser Asn Phe Val Lys Leu Ala Phe Gly Ile Pro Thr Ser Ser 
    690                 695                 700                 


Tyr Ser Glu Phe Ala Glu Lys Leu Phe Ser Asn Phe Ile Pro Val Tyr 
705                 710                 715                 720 


Gln Tyr Gly Ser Val Ile Val Tyr Glu Phe Arg Pro Phe Ala Ile Tyr 
                725                 730                 735     


Lys Ile Glu Asp Phe Ile Asn Gly Thr Trp Arg Glu Val Gly Lys Leu 
            740                 745                 750         


Ser Pro Gly Lys His Thr Leu Arg Leu Tyr Ile Ser Ala Phe Gly Arg 
        755                 760                 765             


Asp Ile Lys Asn Ala Thr Leu Tyr Val Tyr Ala Leu Asn Gly Thr Lys 
    770                 775                 780                 


Ile Ile Lys Arg Ile Lys Val Gly Glu Ile Lys Tyr Met Asn His Leu 
785                 790                 795                 800 


Glu Glu Tyr Pro Ile Ile Val Asn Val Thr Leu Pro Thr Ala Gln Lys 
                805                 810                 815     


Tyr Arg Phe Ile Leu Ala Gln Lys Gly Pro Val Gly Val Leu Thr Gly 
            820                 825                 830         


Pro Val Arg Val Asn Gly Lys Ile Thr Asn Pro Ala Tyr Ile Met Arg 
        835                 840                 845             


Glu Gly Glu Ser Gly Arg Leu Glu Leu Lys Val Gly Val Asp Lys Glu 
    850                 855                 860                 


Tyr Thr Ala Asp Leu Tyr Leu Arg Ala Thr Phe Ile Tyr Leu Val Arg 
865                 870                 875                 880 


Lys Gly Gly Lys Ser Asn Glu Asp Tyr Asp Ala Ser Phe Glu Pro His 
                885                 890                 895     


Met Asp Thr Phe Phe Ile Thr Lys Leu Lys Glu Gly Ile Lys Leu Arg 
            900                 905                 910         


Pro Gly Glu Asn Glu Ile Val Val Asn Ala Glu Met Pro Lys Asn Ala 
        915                 920                 925             


Ile Ser Ser Tyr Lys Glu Lys Leu Glu Lys Glu His Gly Asp Lys Leu 
    930                 935                 940                 


Ile Ile Arg Gly Ile Arg Val Glu Pro Val Phe Ile Val Glu Lys Glu 
945                 950                 955                 960 


Tyr Thr Met Ile Glu Val Ser Ala Ser Ala Pro His His Ser Ser Glu 
                965                 970                 975     


<210>  16
<211>  976
<212>  PRT
<213>  Pyrococcus abyssi

<400>  16

Met Val Lys Thr Lys Val Lys Glu Glu Lys Glu Glu Lys Ser Glu Lys 
1               5                   10                  15      


Ser Glu Gly Lys Ser Leu Tyr Pro Leu Leu Lys Arg Ile Leu Ile Pro 
            20                  25                  30          


Leu Ala Val Ile Gly Phe Gly Ile Tyr Ala Tyr Tyr Leu Arg His Leu 
        35                  40                  45              


Thr Ala Gly Lys Tyr Phe Pro Asp Pro Asp Thr Phe Tyr His Phe Glu 
    50                  55                  60                  


Ile Tyr Lys Leu Val Leu Lys Glu Gly Leu Pro Lys Tyr Tyr Pro Met 
65                  70                  75                  80  


Ala Glu Ala Pro Phe Gly Ser Leu Ile Gly Glu Pro Leu Gly Leu Tyr 
                85                  90                  95      


Ile Leu Pro Ala Ile Phe Tyr Lys Val Val Ser Val Phe Gly Tyr Asn 
            100                 105                 110         


Glu Phe Gln Ala Phe Leu Met Trp Pro Pro Phe Val Gly Phe Leu Gly 
        115                 120                 125             


Val Ile Ala Val Tyr Leu Leu Gly Arg Lys Val Leu Asn Glu Trp Ala 
    130                 135                 140                 


Gly Leu Trp Ala Ala Val Ile Leu Ser Val Ser Thr Ala Asn Phe Ser 
145                 150                 155                 160 


Arg Thr Phe Ser Gly Asn Ala Arg Gly Asp Gly Pro Phe Met Thr Leu 
                165                 170                 175     


Phe Leu Phe Ser Leu Val Ala Met Leu Tyr Tyr Leu Lys Glu Asn Asp 
            180                 185                 190         


Ile Lys Lys Lys Ser Leu Trp Gly Ala Val Phe Val Leu Leu Ala Ser 
        195                 200                 205             


Ile Ser Leu Gly Ala Trp Asn Gly Ser Pro Phe Gly Leu Met Val Leu 
    210                 215                 220                 


Ile Gly Phe Ala Ser Phe Gln Thr Ile Ala Leu Phe Ile Phe Gly Lys 
225                 230                 235                 240 


Ile Lys Glu Leu Lys Lys Phe Val Lys Glu Phe Tyr Pro Ala Tyr Leu 
                245                 250                 255     


Ala Ile Leu Ala Ile Gly Tyr Gly Leu Thr Ile Pro Gly Ile Ala Lys 
            260                 265                 270         


Ile Gly Gly Phe Ile Lys Phe Ala Phe Glu Val Phe Leu Gly Leu Val 
        275                 280                 285             


Leu Leu Val Thr Ile Met Leu Tyr Gly Gly Lys Phe Leu Asn Tyr Ser 
    290                 295                 300                 


Asp Lys Lys His Arg Phe Ala Val Val Ala Val Ile Val Leu Leu Gly 
305                 310                 315                 320 


Phe Ala Gly Ala Tyr Ala Tyr Val Gly Pro Lys Leu Phe Arg Leu Met 
                325                 330                 335     


Gly Gly Ala Tyr Gln Ser Thr Gln Val Tyr Gln Thr Val Gln Glu Leu 
            340                 345                 350         


Ala Lys Thr Thr Leu Ser Asp Ile Lys Leu Tyr Tyr Gly Val Glu Gly 
        355                 360                 365             


Asn Asn Gly Leu Val Phe Phe Leu Ser Ile Pro Gly Phe Leu Ile Ile 
    370                 375                 380                 


Leu Gly Leu Tyr Leu Asn Ala Leu Leu Lys Lys Ser Glu Ser Ser Asn 
385                 390                 395                 400 


Glu Tyr Met Leu Ser Leu Val Phe Tyr Ile Met Ser Leu Tyr Leu Leu 
                405                 410                 415     


Ser Leu Ala Val Arg Phe Leu Phe Leu Ala Ser Tyr Ala Ile Ala Leu 
            420                 425                 430         


Phe Ser Gly Ile Phe Ala Gly Phe Thr Met Glu Val Ile Glu Lys Met 
        435                 440                 445             


Lys Glu Asn Val Gly Ile Lys Ala Ala Leu Gly Ile Ala Ile Ala Val 
    450                 455                 460                 


Met Ile Leu Met Val Pro Ile Thr His Gly Pro Val Ile Ala Arg Asn 
465                 470                 475                 480 


Ala Lys Ala Leu Lys Val Ser Glu Ile Glu Thr Thr Gly Trp Glu Gln 
                485                 490                 495     


Val Leu Lys Trp Leu Asn Glu Asn Thr Ser Lys Tyr Ala Thr Ala Thr 
            500                 505                 510         


Ser Trp Trp Asp Tyr Gly Tyr Trp Ile Glu Ser Ser Leu Leu Gly His 
        515                 520                 525             


Arg Arg Ala Ser Ala Asp Gly Gly His Ala Arg Asp Arg Asp His Ile 
    530                 535                 540                 


Leu Ala Leu Phe Leu Ala Arg Asp Gly Asn Val Ser Glu Val Asp Phe 
545                 550                 555                 560 


Glu Ser Trp Glu Leu Asn Tyr Phe Ile Ile Tyr Leu Asn Asp Trp Ala 
                565                 570                 575     


Lys Phe Asn Ala Ile Ser Tyr Leu Gly Gly Ala Ile Thr Arg Arg Glu 
            580                 585                 590         


Tyr Asn Gly Asp Glu Thr Gly Arg Gly Gln Val Thr Thr Ile Leu Pro 
        595                 600                 605             


Leu Gln Gly Ser Gly Gly Ile Tyr Val Asn Pro Tyr Ala Gly Ile Ser 
    610                 615                 620                 


Val Arg Val Val Gln Ser Asn Thr Thr Ser Lys Val Thr Val Asn Val 
625                 630                 635                 640 


Arg Gly Arg Ala Glu Cys Ser Pro Ile Tyr Thr Leu Leu Ile Pro Gly 
                645                 650                 655     


Asn Lys Lys Ile Pro Gly Asn Gly Arg Cys Ser Asp Gly Ser Pro Phe 
            660                 665                 670         


Pro Tyr Val Leu Tyr Leu Ala Pro Asn Phe Gly Leu Ile Thr Tyr Tyr 
        675                 680                 685             


Lys Val Ala Thr Ser Asn Phe Ile Lys Leu Ala Phe Asn Ile Pro Ile 
    690                 695                 700                 


Ser Lys Tyr Ser Gly Phe Thr Glu Lys Leu Tyr Ser Asn Phe Val Pro 
705                 710                 715                 720 


Val Tyr Gly Tyr Gly Asn Val Ile Val Tyr Glu Phe Arg Pro Phe Ala 
                725                 730                 735     


Ile Tyr Arg Ile Glu Glu Leu Ile Asn Gly Thr Trp Lys Ala Val Asn 
            740                 745                 750         


Ser Leu Thr Pro Gly Lys His Glu Leu Lys Leu Tyr Ile Ser Ala Phe 
        755                 760                 765             


Gly Arg Asp Ile Arg Asn Ala Thr Leu Tyr Val Tyr Ala Ile Gly Asn 
    770                 775                 780                 


Lys Thr Glu Lys Ile Lys Ile Gly Glu Ile Glu Tyr Met Asn His Leu 
785                 790                 795                 800 


Asn Glu Lys Pro Ile Ile Val Asn Val Thr Leu Pro Lys Ala Glu Lys 
                805                 810                 815     


Tyr Arg Leu Val Leu Val Gln Lys Gly Pro Val Gly Val Leu Thr Gly 
            820                 825                 830         


Pro Pro Lys Leu Asn Gly Glu Ile Ala Asn Pro Ile Arg Ile Ala Arg 
        835                 840                 845             


Glu Gly Glu Lys Gly Thr Leu Ser Leu Lys Val Gly Val Asp Lys Asp 
    850                 855                 860                 


Tyr Thr Ala Asp Leu Tyr Leu Arg Ala Thr Phe Ile Tyr Leu Val Arg 
865                 870                 875                 880 


Lys Glu Gly Lys Ser Asn Asp Asp Tyr Asn Ala Ala Phe Glu Pro His 
                885                 890                 895     


Met Asp Thr Phe Phe Ile Thr Lys Leu Lys Gly Gly Ile Lys Leu His 
            900                 905                 910         


Lys Gly Asp Asn Val Val Thr Ala Glu Leu Asn Met Pro Asn Gly Val 
        915                 920                 925             


Ile Ser Ser Tyr Lys Glu Lys Leu Glu Lys Glu Tyr Gly Asp Lys Leu 
    930                 935                 940                 


Ile Ile Arg Gly Ile Arg Val Glu Pro Val Phe Ile Ala Glu Lys Glu 
945                 950                 955                 960 


Tyr Val Met Ala Glu Val Arg Ala Ser Ala Pro His His Gly Ser Glu 
                965                 970                 975     


<210>  17
<211>  972
<212>  PRT
<213>  Pyrococcus yayanossi

<400>  17

Met Val Lys Thr Lys Val Lys Arg Glu Lys Arg Glu Glu Lys Ala Pro 
1               5                   10                  15      


Glu His Arg Pro Lys Thr Leu Val Val Phe Phe Lys Arg Phe Gly Ile 
            20                  25                  30          


Pro Leu Ile Val Leu Ala Phe Ala Thr Leu Gly Phe Tyr Ile Arg Tyr 
        35                  40                  45              


Leu Pro Gly Thr Gly Lys Tyr Phe Ile Asp Pro Asp Thr Tyr Tyr His 
    50                  55                  60                  


Tyr Glu Ile Tyr Lys Leu Val Leu Lys Glu Gly Leu Pro Arg Tyr Tyr 
65                  70                  75                  80  


Ser Met Ala Glu Ala Pro Phe Gly Ser Leu Ile Gly Glu Pro Leu Gly 
                85                  90                  95      


Leu Tyr Leu Leu Pro Ala Ile Phe Tyr Lys Leu Ile Ser Ala Phe Gly 
            100                 105                 110         


Tyr Thr Thr Leu Gln Ala Phe Lys Leu Trp Pro Pro Thr Val Gly Phe 
        115                 120                 125             


Leu Ser Ile Ile Ala Thr Tyr Leu Leu Ala Arg Lys Ile His Gly Glu 
    130                 135                 140                 


Trp Ala Gly Leu Trp Ser Ala Ala Ile Met Ser Phe Leu Leu Ala His 
145                 150                 155                 160 


Phe Thr Arg Thr Phe Ser Gly Asn Ala Arg Gly Asp Gly Pro Phe Leu 
                165                 170                 175     


Met Leu Phe Leu Phe Ala Ser Val Ala Met Leu Tyr Tyr Leu Glu Ala 
            180                 185                 190         


Lys Asp Val Lys Arg Lys Met Val Tyr Gly Thr Leu Phe Val Ala Leu 
        195                 200                 205             


Ser Val Ile Ala Leu Ser Ala Trp Asn Gly Ser Pro Phe Ser Leu Met 
    210                 215                 220                 


Val Phe Leu Gly Phe Gly Ala Leu Gln Ala Ile Val Leu Phe Val Phe 
225                 230                 235                 240 


Gly Arg Ile Glu Glu Leu Arg Glu Phe Ile Lys Leu Tyr Tyr Pro Thr 
                245                 250                 255     


Tyr Leu Thr Val Leu Leu Leu Gly Tyr Leu Leu Thr Phe Pro Arg Ile 
            260                 265                 270         


Val Ala Val Lys Gly His Ile Leu Phe Ala Leu Lys Val Phe Leu Gly 
        275                 280                 285             


Leu Ala Gly Leu Thr Val Leu Met Leu Tyr Gly Gly Lys Trp Leu Asn 
    290                 295                 300                 


Tyr Ser Asp Arg Arg His Arg Phe Ala Val Val Ala Val Val Thr Leu 
305                 310                 315                 320 


Leu Gly Phe Val Gly Ala Tyr Ile Tyr Val Gly Pro Lys Leu Phe Ser 
                325                 330                 335     


Leu Met Ala Gly Ala Tyr Gln Ser Thr Gln Val Tyr Glu Thr Val Gln 
            340                 345                 350         


Glu Leu Ala Lys Thr Thr Leu Gly Asp Ile Lys Ala Tyr Tyr Gly Ile 
        355                 360                 365             


Lys Gly Thr Asp Gly Ile Val Phe Phe Met Ser Leu Ala Gly Val Leu 
    370                 375                 380                 


Val Leu Leu Tyr Arg Tyr Leu Thr Thr Leu Leu Arg Glu Gly Arg Ser 
385                 390                 395                 400 


Ser His Glu Tyr Leu Phe Ala Leu Thr Leu Tyr Gly Met Ser Leu Tyr 
                405                 410                 415     


Leu Val Trp Ser Ala Val Arg Phe Leu Phe Leu Ala Ser Gly Ala Val 
            420                 425                 430         


Ile Leu Met Ala Gly Val Phe Ala Gly Glu Leu Phe Arg Ile Ile Glu 
        435                 440                 445             


Asp Met Lys Glu Lys Ala Thr Thr Lys Ile Thr Leu Gly Leu Ala Leu 
    450                 455                 460                 


Thr Val Met Leu Leu Leu Met Pro Val Thr Gly Val Pro Leu Met Ile 
465                 470                 475                 480 


Asn Thr Ala Lys Ala Met Lys Thr Ser Glu Val Glu Arg Ser Gly Trp 
                485                 490                 495     


Glu Asp Ala Leu Met Trp Leu Arg Glu Asn Thr Ser Glu Tyr Ala Thr 
            500                 505                 510         


Ala Thr Ser Trp Trp Asp Tyr Gly Tyr Trp Ile Glu Ser Ser Leu Leu 
        515                 520                 525             


Gly Asn Arg Arg Ala Ser Ala Asp Gly Gly His Ala Arg Asp Arg Asp 
    530                 535                 540                 


His Ile Leu Ala Leu Phe Leu Ala Arg Asp Gly Asn Val Ser Glu Val 
545                 550                 555                 560 


Asp Phe Glu Ser Trp Glu Leu Asn Tyr Phe Ile Ala Tyr Met Gln Asp 
                565                 570                 575     


Trp Arg Lys Phe Asn Ala Ile Ser Tyr Leu Gly Gly Ala Ile Thr Arg 
            580                 585                 590         


Arg Glu Tyr Lys Gly Asp Glu Ser Gly Arg Gly Gly Val Thr Thr Ile 
        595                 600                 605             


Val Leu Leu Pro Gly Ala Asn Gly Val Tyr Ser Asn Pro Tyr Met Gly 
    610                 615                 620                 


Leu Thr Leu Arg Val Glu Asn Arg Thr Val Lys Val Asn Gly Tyr Cys 
625                 630                 635                 640 


Glu Pro Met Glu Ser Val Ile Leu Pro Ser Asn Thr His Ile Lys Gly 
                645                 650                 655     


Ser Gly Gln Cys Glu Thr Gly Ser Tyr Phe Pro Tyr Val Ala Tyr Val 
            660                 665                 670         


Thr Pro Thr Phe Ala Val Leu Ala Tyr Tyr Lys Val Ala Thr Ser Asn 
        675                 680                 685             


Phe Leu Lys Leu Ala Phe Gly Ile Pro Ala Ser Lys Glu Ala Asn Phe 
    690                 695                 700                 


Thr Glu Lys Leu Tyr Ala Asn Phe Glu Leu Val Phe Gln Ser Gly Asp 
705                 710                 715                 720 


Val Ile Val Tyr Glu Phe Lys Pro Phe Ala Val Tyr Lys Ala Glu Glu 
                725                 730                 735     


Leu Val Asn Gly Thr Trp Arg Ala Val Glu Thr Leu Thr Pro Gly Glu 
            740                 745                 750         


His Thr Leu Lys Leu Tyr Ile Ser Ala Phe Gly Arg Asp Val Lys Asn 
        755                 760                 765             


Ala Thr Leu Tyr Val Glu Ala Leu Lys Asp Gly Lys Val Val Glu Arg 
    770                 775                 780                 


Ile Lys Val Ala Glu Gly Leu Tyr Ile Asp His Leu Asn Glu Lys Pro 
785                 790                 795                 800 


Ile Glu Val Lys Val Asn Leu Pro Glu Ala Asp Glu Tyr Arg Phe Val 
                805                 810                 815     


Leu Val Gln Lys Gly Pro Val Gly Val Leu Thr Ser Ala Pro Arg Val 
            820                 825                 830         


Asn Gly Ser Ile Ala Asn Pro Ile Lys Val Leu Gly Glu Gly Gln Ser 
        835                 840                 845             


Gly Thr Leu Glu Leu Lys Ala Ala Phe Asp Arg Asp Tyr Thr Ala Asp 
    850                 855                 860                 


Leu Tyr Leu Arg Val Thr Phe Ile Tyr Leu Val Arg Lys Ser Gly Arg 
865                 870                 875                 880 


Ser Asn Asp Asp Ile Asp Ala Ala Phe Glu Pro His Met Asp Thr Phe 
                885                 890                 895     


Phe Ala Ala Lys Leu Ala Glu Gly Leu Lys Leu Lys Lys Gly Glu Asp 
            900                 905                 910         


Thr Ile Thr Val Asn Ala Gly Leu Pro Ala Gly Val Ile Ser Ser Tyr 
        915                 920                 925             


Glu Glu Lys Leu Lys Ala Leu Tyr Gly Asp Arg Leu Ile Ile Arg Gly 
    930                 935                 940                 


Ile Arg Val Glu Pro Val Phe Ile Ala Asp Lys Ala Tyr Thr Ile Trp 
945                 950                 955                 960 


Glu Val Arg Ala Ser Ala Pro His His Gly Ser Glu 
                965                 970         


<210>  18
<211>  982
<212>  PRT
<213>  Artificial

<220>
<223>  Pyrococcus STT3 consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (31)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (83)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (109)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (116)..(119)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (122)..(123)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (127)..(127)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(136)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (143)..(145)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (148)..(148)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (150)..(150)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(160)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (162)..(162)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (178)..(179)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (182)..(182)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (184)..(190)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (193)..(199)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (201)..(203)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (205)..(206)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (209)..(209)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (211)..(216)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (224)..(224)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (228)..(229)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (232)..(234)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (236)..(236)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (238)..(238)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (241)..(241)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (244)..(246)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (249)..(250)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (252)..(255)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (258)..(258)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (260)..(262)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (264)..(266)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (268)..(268)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (271)..(271)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (273)..(282)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (285)..(286)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (292)..(293)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (295)..(297)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (302)..(304)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (310)..(311)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (315)..(315)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (318)..(323)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (326)..(326)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (330)..(330)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (338)..(338)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (341)..(341)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (351)..(351)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (360)..(362)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (364)..(364)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (366)..(366)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (370)..(374)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (376)..(377)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (380)..(383)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (385)..(391)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (394)..(395)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (397)..(412)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (414)..(414)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (417)..(417)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (420)..(422)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (424)..(424)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (432)..(432)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (434)..(435)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (437)..(438)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (440)..(442)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (444)..(449)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (451)..(451)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (455)..(458)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (460)..(461)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (463)..(468)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (470)..(470)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (472)..(473)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (475)..(478)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (480)..(484)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (486)..(491)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (493)..(493)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (495)..(496)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (500)..(501)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (503)..(503)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (506)..(507)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (510)..(511)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (513)..(513)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (532)..(532)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (559)..(559)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (573)..(574)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (576)..(577)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (580)..(580)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (592)..(592)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (594)..(595)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (598)..(598)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (602)..(602)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (606)..(619)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (621)..(621)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (623)..(623)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (625)..(630)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (632)..(649)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (651)..(651)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (653)..(658)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (660)..(665)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (667)..(667)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (669)..(669)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (671)..(672)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (674)..(675)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (678)..(678)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (680)..(683)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (685)..(690)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (697)..(697)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (700)..(700)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (704)..(706)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (708)..(708)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (710)..(713)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (715)..(716)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (719)..(720)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (723)..(724)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (726)..(728)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (730)..(730)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (732)..(733)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (735)..(735)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (737)..(737)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (740)..(741)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (743)..(748)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (751)..(751)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (753)..(757)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (759)..(759)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (762)..(762)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (764)..(764)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (766)..(766)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (776)..(777)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (783)..(784)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (786)..(794)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (796)..(805)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (807)..(807)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (809)..(809)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (812)..(812)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (814)..(814)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (816)..(816)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (819)..(819)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (821)..(822)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (824)..(826)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (828)..(828)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (833)..(833)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (837)..(842)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (845)..(845)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (847)..(848)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (850)..(855)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (857)..(858)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (860)..(862)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (865)..(867)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (869)..(870)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (872)..(872)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (879)..(879)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (888)..(888)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (890)..(891)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (893)..(893)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (895)..(896)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (898)..(898)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (902)..(902)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (905)..(905)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (908)..(916)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (918)..(919)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (921)..(930)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (932)..(934)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (937)..(937)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (939)..(941)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (943)..(946)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (949)..(949)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (963)..(964)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (966)..(966)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (968)..(970)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (973)..(973)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (980)..(982)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Xaa Val Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Arg Xaa Leu Xaa Xaa Xaa Gly Xaa Tyr Phe Xaa Asp Pro Asp Thr Xaa 
    50                  55                  60                  


Tyr His Xaa Glu Ile Tyr Lys Leu Val Xaa Lys Glu Gly Leu Pro Xaa 
65                  70                  75                  80  


Tyr Tyr Xaa Xaa Xaa Xaa Ala Pro Phe Gly Ser Leu Ile Gly Glu Pro 
                85                  90                  95      


Leu Gly Leu Tyr Xaa Leu Pro Ala Xaa Phe Tyr Lys Xaa Xaa Ser Xaa 
            100                 105                 110         


Phe Gly Tyr Xaa Xaa Xaa Xaa Ala Phe Xaa Xaa Trp Pro Pro Xaa Val 
        115                 120                 125             


Gly Phe Leu Xaa Xaa Xaa Xaa Xaa Tyr Leu Leu Xaa Arg Lys Xaa Xaa 
    130                 135                 140                 


Xaa Glu Trp Xaa Gly Xaa Trp Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Ala Xaa Phe Xaa Arg Thr Phe Ser Gly Asn Ala Arg Gly Asp Gly Pro 
                165                 170                 175     


Phe Xaa Xaa Leu Phe Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Leu 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Gly Xaa Xaa Phe Val 
        195                 200                 205             


Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Ala Trp Asn Gly Ser Pro Phe Xaa 
    210                 215                 220                 


Leu Met Val Xaa Xaa Gly Phe Xaa Xaa Xaa Gln Xaa Ile Xaa Leu Phe 
225                 230                 235                 240 


Xaa Phe Gly Xaa Xaa Xaa Glu Leu Xaa Xaa Phe Xaa Xaa Xaa Xaa Tyr 
                245                 250                 255     


Pro Xaa Tyr Xaa Xaa Xaa Leu Xaa Xaa Xaa Tyr Xaa Leu Thr Xaa Pro 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Ala Xaa Xaa Val Phe 
        275                 280                 285             


Leu Gly Leu Xaa Xaa Leu Xaa Xaa Xaa Met Leu Tyr Gly Xaa Xaa Xaa 
    290                 295                 300                 


Leu Asn Tyr Ser Asp Xaa Xaa His Arg Phe Xaa Val Val Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Gly Phe Xaa Gly Ala Tyr Xaa Tyr Val Gly Pro Lys Leu 
                325                 330                 335     


Phe Xaa Leu Met Xaa Gly Ala Tyr Gln Ser Thr Gln Val Tyr Xaa Thr 
            340                 345                 350         


Val Gln Glu Leu Ala Lys Lys Xaa Xaa Xaa Asp Xaa Lys Xaa Tyr Tyr 
        355                 360                 365             


Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Phe Phe Xaa Xaa Xaa Xaa Gly 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Leu Xaa Xaa Leu Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Met Ser 
                405                 410                 415     


Xaa Tyr Leu Xaa Xaa Xaa Ala Xaa Arg Phe Leu Phe Leu Ala Ser Xaa 
            420                 425                 430         


Ala Xaa Xaa Leu Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Glu Xaa Met Lys Glu Xaa Xaa Xaa Xaa Lys Xaa Xaa Leu Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Met Xaa Leu Xaa Xaa Pro Xaa Xaa Xaa Xaa Pro Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Glu Xaa Xaa 
                485                 490                 495     


Gly Trp Glu Xaa Xaa Leu Xaa Trp Leu Xaa Xaa Asn Thr Xaa Xaa Tyr 
            500                 505                 510         


Xaa Thr Ala Thr Ser Trp Trp Asp Tyr Gly Tyr Trp Ile Glu Ser Ser 
        515                 520                 525             


Leu Leu Gly Xaa Arg Arg Ala Ser Ala Asp Gly Gly His Ala Arg Asp 
    530                 535                 540                 


Arg Asp His Ile Leu Ala Leu Phe Leu Ala Arg Asp Gly Asn Xaa Ser 
545                 550                 555                 560 


Glu Val Asp Phe Glu Ser Trp Glu Leu Asn Tyr Phe Xaa Xaa Tyr Xaa 
                565                 570                 575     


Xaa Asp Trp Xaa Lys Phe Asn Ala Ile Ser Tyr Leu Gly Gly Ala Xaa 
            580                 585                 590         


Thr Xaa Xaa Glu Tyr Xaa Gly Asp Glu Xaa Gly Arg Gly Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Asn Xaa Tyr 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Pro Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Gly Xaa Cys Xaa Xaa 
            660                 665                 670         


Gly Xaa Xaa Phe Pro Xaa Val Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Tyr Tyr Lys Val Ala Thr Xaa Asn Phe Xaa Lys Leu Ala Xaa 
    690                 695                 700                 


Xaa Xaa Pro Xaa Ser Xaa Xaa Xaa Xaa Phe Xaa Xaa Lys Leu Xaa Xaa 
705                 710                 715                 720 


Asn Phe Xaa Xaa Val Xaa Xaa Xaa Gly Xaa Val Xaa Xaa Tyr Xaa Phe 
                725                 730                 735     


Xaa Pro Phe Xaa Xaa Tyr Xaa Xaa Xaa Xaa Xaa Xaa Asn Gly Xaa Trp 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Leu Xaa Pro Gly Xaa His Xaa Leu Xaa Leu Tyr 
        755                 760                 765             


Ile Ser Ala Phe Gly Arg Asp Xaa Xaa Asn Ala Thr Leu Tyr Xaa Xaa 
    770                 775                 780                 


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Leu Xaa Glu Xaa Pro Ile Xaa Val Xaa Val Xaa 
                805                 810                 815     


Leu Pro Xaa Ala Xaa Xaa Tyr Xaa Xaa Xaa Leu Xaa Gln Lys Gly Pro 
            820                 825                 830         


Xaa Gly Val Leu Xaa Xaa Xaa Xaa Xaa Xaa Asn Gly Xaa Ile Xaa Xaa 
        835                 840                 845             


Pro Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Xaa Leu Lys 
    850                 855                 860                 


Xaa Xaa Xaa Asp Xaa Xaa Tyr Xaa Ala Asp Leu Tyr Leu Arg Xaa Thr 
865                 870                 875                 880 


Phe Ile Tyr Leu Val Arg Lys Xaa Gly Xaa Xaa Asn Xaa Asp Xaa Xaa 
                885                 890                 895     


Ala Xaa Phe Glu Pro Xaa Met Asp Xaa Phe Phe Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Leu Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Pro Xaa Xaa Xaa Ile Ser Xaa Tyr Xaa Xaa Xaa Leu Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Gly Asp Xaa Leu Ile Ile Arg Gly Ile Arg Val Glu Pro Val 
945                 950                 955                 960 


Phe Ile Xaa Xaa Lys Xaa Tyr Xaa Xaa Xaa Glu Val Xaa Ala Ser Ala 
                965                 970                 975     


Pro His His Xaa Xaa Xaa 
            980         


<210>  19
<211>  833
<212>  PRT
<213>  Leishmania major

<400>  19

Met Ala Ala Ala Ser Asn Val Asn Ala Pro Glu Ser Asn Val Met Thr 
1               5                   10                  15      


Thr Arg Ser Ala Val Ala Pro Pro Ser Thr Ala Ala Pro Lys Glu Ala 
            20                  25                  30          


Ser Ser Glu Thr Leu Leu Ile Gly Leu Tyr Lys Met Pro Ser Gln Thr 
        35                  40                  45              


Arg Ser Leu Ile Tyr Ser Ser Cys Phe Ala Val Ala Met Ala Ile Ala 
    50                  55                  60                  


Leu Pro Ile Ala Tyr Asp Met Arg Val Arg Ser Ile Gly Val Tyr Gly 
65                  70                  75                  80  


Tyr Leu Phe His Ser Ser Asp Pro Trp Phe Asn Tyr Arg Ala Ala Glu 
                85                  90                  95      


Tyr Met Ser Thr His Gly Trp Ser Ala Phe Phe Ser Trp Phe Asp Tyr 
            100                 105                 110         


Met Ser Trp Tyr Pro Leu Gly Arg Pro Val Gly Ser Thr Thr Tyr Pro 
        115                 120                 125             


Gly Leu Gln Leu Thr Ala Val Ala Ile His Arg Ala Leu Ala Ala Ala 
    130                 135                 140                 


Gly Met Pro Met Ser Leu Asn Asn Val Cys Val Leu Met Pro Ala Trp 
145                 150                 155                 160 


Phe Ser Leu Val Ser Ser Ala Met Ala Ala Leu Leu Ala His Glu Met 
                165                 170                 175     


Ser Gly Asn Met Ala Val Ala Ser Ile Ser Ser Ile Leu Phe Ser Val 
            180                 185                 190         


Val Pro Ala His Leu Met Arg Ser Met Ala Gly Glu Phe Asp Asn Glu 
        195                 200                 205             


Cys Ile Ala Val Ala Ala Met Leu Leu Thr Phe Tyr Cys Trp Val Arg 
    210                 215                 220                 


Ser Leu Arg Thr Arg Ser Ser Trp Pro Ile Gly Val Leu Thr Gly Val 
225                 230                 235                 240 


Ala Tyr Gly Tyr Met Ala Ala Ala Trp Gly Gly Tyr Ile Phe Val Leu 
                245                 250                 255     


Asn Met Val Ala Met His Ala Gly Ile Ser Ser Met Val Asp Trp Ala 
            260                 265                 270         


Arg Asn Thr Tyr Asn Pro Ser Leu Leu Arg Ala Tyr Thr Leu Phe Tyr 
        275                 280                 285             


Val Val Gly Thr Ala Ile Ala Val Cys Val Pro Pro Val Gly Met Ser 
    290                 295                 300                 


Pro Phe Lys Ser Leu Glu Gln Leu Gly Ala Leu Leu Val Leu Val Phe 
305                 310                 315                 320 


Ile Phe Gly Gln Ser Val Cys Glu Ala Gln Arg Arg Arg Leu Gly Ile 
                325                 330                 335     


Ala Arg Leu Ser Lys Glu Gly Val Ala Leu Leu Ile Arg Ile Asp Ala 
            340                 345                 350         


Ala Phe Phe Val Gly Ile Val Ala Val Ala Thr Ile Ala Pro Ala Gly 
        355                 360                 365             


Phe Phe Lys Pro Leu Ser Leu Gln Ala Asn Ala Ile Ile Thr Gly Val 
    370                 375                 380                 


Ser Arg Thr Gly Asn Thr Leu Val Asp Ile Leu Leu Ala Gln Asp Ala 
385                 390                 395                 400 


Ser Asn Leu Leu Met Val Trp Gln Leu Phe Leu Phe Pro Phe Leu Gly 
                405                 410                 415     


Trp Val Ala Gly Met Ser Ala Phe Leu Arg Glu Leu Ile Arg Asn Tyr 
            420                 425                 430         


Thr Tyr Ala Lys Ser Phe Ile Leu Met Tyr Gly Val Val Gly Met Tyr 
        435                 440                 445             


Phe Ala Ser Gln Ser Val Arg Met Met Val Met Met Ala Pro Val Ala 
    450                 455                 460                 


Cys Ile Phe Thr Ala Leu Leu Phe Arg Trp Ala Leu Asp Tyr Leu Leu 
465                 470                 475                 480 


Gly Ser Leu Phe Trp Ala Glu Met Pro Pro Ser Phe Asp Thr Asp Ala 
                485                 490                 495     


Gln Arg Gly Arg Gln Gln Gln Thr Ala Glu Glu Ser Glu Ala Glu Thr 
            500                 505                 510         


Lys Arg Lys Glu Glu Glu Tyr Asn Thr Met Gln Val Lys Lys Met Ser 
        515                 520                 525             


Val Arg Met Leu Pro Phe Met Leu Leu Leu Leu Leu Phe Arg Leu Ser 
    530                 535                 540                 


Gly Phe Ile Glu Asp Val Ala Ala Ile Ser Arg Lys Met Glu Ala Pro 
545                 550                 555                 560 


Gly Ile Val Phe Pro Ser Glu Gln Val Gln Gly Val Ser Glu Lys Lys 
                565                 570                 575     


Val Asp Asp Tyr Tyr Ala Gly Tyr Leu Tyr Leu Arg Asp Ser Thr Pro 
            580                 585                 590         


Glu Asp Ala Arg Val Leu Ala Trp Trp Asp Tyr Gly Tyr Gln Ile Thr 
        595                 600                 605             


Gly Ile Gly Asn Arg Thr Ser Leu Ala Asp Gly Asn Thr Trp Asn His 
    610                 615                 620                 


Glu His Ile Ala Thr Ile Gly Lys Met Leu Thr Ser Pro Val Ala Glu 
625                 630                 635                 640 


Ala His Ser Leu Val Arg His Met Ala Asp Tyr Val Leu Ile Ser Ala 
                645                 650                 655     


Gly Asp Thr Tyr Phe Ser Asp Leu Asn Arg Ser Pro Met Met Ala Arg 
            660                 665                 670         


Ile Gly Asn Ser Val Tyr His Asp Ile Cys Pro Asp Asp Pro Leu Cys 
        675                 680                 685             


Ser Gln Phe Val Leu Gln Lys Arg Pro Lys Ala Ala Ala Ala Lys Arg 
    690                 695                 700                 


Ser Arg His Val Ser Val Asp Ala Leu Glu Glu Asp Asp Thr Ala Glu 
705                 710                 715                 720 


His Met Val Tyr Glu Pro Ser Ser Leu Ile Ala Lys Ser Leu Ile Tyr 
                725                 730                 735     


His Leu His Ser Thr Gly Val Val Thr Gly Val Thr Leu Asn Glu Thr 
            740                 745                 750         


Leu Phe Gln His Val Phe Thr Ser Pro Gln Gly Leu Met Arg Ile Phe 
        755                 760                 765             


Lys Val Met Asn Val Ser Thr Glu Ser Lys Lys Trp Val Ala Asp Ser 
    770                 775                 780                 


Ala Asn Arg Val Cys His Pro Pro Gly Ser Trp Ile Cys Pro Gly Gln 
785                 790                 795                 800 


Tyr Pro Pro Ala Lys Glu Ile Gln Glu Met Leu Ala His Gln His Thr 
                805                 810                 815     


Asn Phe Lys Asp Leu Leu Asp Pro Arg Thr Thr Trp Ser Gly Ser Arg 
            820                 825                 830         


Arg 
    


<210>  20
<211>  2502
<212>  DNA
<213>  Leishmania major

<400>  20
atggcggcag cgtcaaacgt gaatgccccc gaaagcaacg tgatgacaac gagaagtgcc       60

gttgcaccac cgtcgacggc tgcacccaaa gaggcttcaa gtgaaacgct gctcattggc      120

ctatacaaga tgccctcgca aactcgtagc ctcatctact cctcctgctt tgcggtggcc      180

atggccattg ccctccctat cgcgtacgac atgcgtgtcc gctccatcgg cgtgtacggg      240

tacctcttcc acagcagtga cccgtggttc aactaccgcg ctgccgagta catgtccacg      300

cacggctggt ccgccttctt cagctggttc gactacatga gctggtaccc gctgggccgc      360

cccgtcggct ccaccacgta cccgggcctg cagctcactg ccgtcgccat tcaccgcgca      420

ctggcggctg ccggcatgcc gatgtctctc aacaacgtgt gcgtgctgat gccagcgtgg      480

ttttcacttg tctcttcagc gatggcggca ctgctggcgc atgagatgag cggcaatatg      540

gcggtagcca gcatctcgtc tatcttattc agtgtggttc cagcccacct gatgcggtcc      600

atggcgggtg agttcgacaa cgagtgtatc gccgtcgcag ccatgctcct caccttctac      660

tgctgggtgc gctcgctgcg cacgcggtcc tcgtggccca tcggtgtcct caccggtgtc      720

gcctacggct acatggcggc ggcgtggggc ggctacattt tcgtgctcaa catggttgcc      780

atgcatgccg gcatatcatc gatggtggac tgggcccgca acacgtacaa cccgtcgctg      840

ctgcgtgcat acacgctgtt ctacgtcgtg ggcaccgcca tcgccgtgtg cgtgccgcca      900

gtggggatgt cgcccttcaa gtcgctggag cagctgggtg cgctgctggt gcttgtcttc      960

attttcggtc agtctgtgtg tgaggcccag cgcagacgat tgggaatcgc gcgcctttca     1020

aaggagggcg tggcgctgct catccgcatc gacgcagcct tcttcgtcgg tatcgttgcc     1080

gtggccacca ttgccccggc tggattcttc aagccgctct ccctgcaagc gaacgcgata     1140

atcactggcg tatctcgtac cggaaacaca ctcgtagaca ttctgcttgc gcaagacgcg     1200

tccaacctac tcatggtgtg gcagcttttt ctctttccct tcttaggttg ggtggcgggc     1260

atgagcgcct tccttagaga gttgatccgg aactacacct acgcgaagag tttcatcctg     1320

atgtacggcg tggtcggtat gtacttcgcc agccagtctg tccgaatgat ggtgatgatg     1380

gcccccgtgg cgtgcatctt tactgccctc ttgttccgct gggcactgga ctacctcctc     1440

gggtctttgt tttgggctga gatgccacct tcctttgaca ccgacgcaca gcgtgggcgg     1500

cagcaacaga ccgccgagga gtcggaggca gagaccaagc gtaaggagga agagtacaac     1560

accatgcagg tcaagaagat gtcggtgcgc atgttgccct tcatgctgtt gctcttactg     1620

tttcgtcttt cggggttcat cgaagatgtg gcggcgatat cgcgcaagat ggaggcgccg     1680

ggtatagttt ttcccagtga acaggtgcaa ggcgtgtcgg agaaaaaggt cgacgactac     1740

tatgcggggt acctgtatct gcgcgacagc acgccagagg acgcgcgcgt tttggcctgg     1800

tgggactacg gctaccagat cacaggcatc ggcaaccgca cctcgctggc cgatggcaac     1860

acctggaacc acgagcacat cgccacgatc ggcaagatgc tgacgtcgcc cgtggcggag     1920

gcgcactcgc tggtgcgcca catggccgac tatgttctga tttctgctgg agacacatat     1980

ttttccgacc tgaatcgctc accgatgatg gcgcgcatcg gcaacagcgt gtaccacgac     2040

atctgccccg acgacccact ttgtagtcag ttcgtgttgc agaaaagacc gaaagctgct     2100

gcagcgaagc gcagtcggca cgtcagcgtt gacgcactag aggaggatga cactgcagag     2160

catatggtat acgagccgtc atcactcata gccaagtcgc tcatatatca cctgcactcc     2220

acaggggtgg tgacgggggt cacgctgaat gagacgctct tccagcacgt cttcacctca     2280

ccgcagggtc tcatgcgcat cttcaaggtc atgaacgtga gcacggagag caaaaagtgg     2340

gttgctgact cggcaaaccg cgtgtgccac ccgcctgggt cgtggatctg ccccgggcag     2400

tacccgccgg cgaaggagat ccaggagatg ctggcacacc aacacaccaa cttcaaggac     2460

cttcttgatc ccagaacgac ttggagcggg agcaggcgct ga                        2502


<210>  21
<211>  794
<212>  PRT
<213>  Leishmania donovani

<400>  21

Met Ser Ser Gln Thr Arg Ser Ile Ile Tyr Ser Ser Cys Phe Ala Val 
1               5                   10                  15      


Ala Met Ala Ile Ala Leu Pro Ile Ala Tyr Asp Met Arg Val Arg Ser 
            20                  25                  30          


Ile Gly Val Tyr Gly Tyr Leu Phe His Arg Ser Asp Pro Trp Phe Asn 
        35                  40                  45              


Tyr Arg Ala Ala Glu Tyr Met Ser Thr His Gly Trp Ser Ala Phe Phe 
    50                  55                  60                  


Ser Trp Phe Asp Tyr Met Ser Trp Tyr Pro Leu Gly Arg Pro Val Gly 
65                  70                  75                  80  


Ser Thr Thr Tyr Pro Gly Leu Gln Leu Thr Ala Val Ala Ile His Arg 
                85                  90                  95      


Ala Leu Ala Ala Ala Gly Met Pro Met Ser Leu Asn Asn Val Cys Val 
            100                 105                 110         


Leu Met Pro Ala Trp Phe Ser Leu Val Ser Ser Ala Met Val Ala Leu 
        115                 120                 125             


Leu Ala His Glu Leu Ser Gly Asn Met Ala Val Ala Ser Ile Ser Ser 
    130                 135                 140                 


Ile Leu Phe Ser Val Val Pro Ala His Leu Met Arg Ser Met Ala Gly 
145                 150                 155                 160 


Glu Phe Asp Asn Glu Cys Ile Ala Val Ala Ala Met Leu Leu Thr Phe 
                165                 170                 175     


Tyr Cys Trp Val Arg Ser Leu Arg Thr Arg Ser Ser Trp Pro Ile Gly 
            180                 185                 190         


Val Leu Thr Gly Val Ala Tyr Gly Tyr Met Val Ala Ala Trp Gly Gly 
        195                 200                 205             


Tyr Ile Phe Val Leu Asn Met Val Ala Met His Ala Gly Ile Ser Ser 
    210                 215                 220                 


Met Val Asp Trp Ala Arg Asn Thr Tyr Asn Pro Ser Leu Leu Arg Ala 
225                 230                 235                 240 


Tyr Thr Leu Phe Tyr Val Val Gly Thr Ala Ile Ala Val Cys Val Pro 
                245                 250                 255     


Pro Val Gly Met Ser Pro Phe Lys Ser Leu Glu Gln Leu Gly Ala Leu 
            260                 265                 270         


Leu Val Leu Leu Phe Ile Phe Gly Gln Ser Val Cys Glu Ala Gln Arg 
        275                 280                 285             


Arg Arg Leu Glu Ile Ala Arg Phe Ser Lys Glu Gly Val Ala Leu Leu 
    290                 295                 300                 


Ile Arg Ile Tyr Ala Ala Phe Phe Val Gly Ile Val Ala Val Ala Thr 
305                 310                 315                 320 


Ile Ala Pro Ala Gly Phe Phe Lys Pro Leu Ser Leu Gln Ala Ser Ala 
                325                 330                 335     


Ile Ile Thr Gly Val Ser Arg Thr Gly Asn Thr Leu Val Asp Thr Leu 
            340                 345                 350         


Ile Ala Gln Asp Ala Ser Asn Leu Leu Ile Val Trp Gln Leu Phe Leu 
        355                 360                 365             


Phe Pro Val Phe Gly Trp Val Ala Gly Met Ser Ala Phe Leu Thr Glu 
    370                 375                 380                 


Leu Val Arg Asn Tyr Thr Tyr Thr Lys Ser Phe Met Leu Met Tyr Gly 
385                 390                 395                 400 


Val Val Gly Leu Tyr Phe Ala Ser Gln Ser Val Arg Met Met Val Met 
                405                 410                 415     


Met Ala Pro Val Ala Cys Ile Phe Thr Ala Leu Leu Phe Arg Trp Ala 
            420                 425                 430         


Leu Asp Tyr Leu Leu Gly Ser Leu Phe Trp Ala Glu Met Pro Pro Cys 
        435                 440                 445             


Phe Asp Thr Asp Ala Gln Arg Gly Arg Gln Gln Gln Thr Ala Glu Glu 
    450                 455                 460                 


Ala Glu Ala Glu Thr Lys Arg Lys Glu Glu Glu Tyr Asn Thr Met Gln 
465                 470                 475                 480 


Val Lys Lys Met Thr Thr Arg Met Leu Pro Phe Met Phe Leu Leu Leu 
                485                 490                 495     


Leu Phe Arg Leu Ser Gly Phe Ile Glu Asp Val Ala Ala Ile Ser Arg 
            500                 505                 510         


Glu Met Glu Ala Pro Gly Ile Val Phe Pro Ser Gly Gln Val Gln Gly 
        515                 520                 525             


Val Ser Glu Lys Lys Val Asp Asp Tyr Tyr Ala Gly Tyr Leu Tyr Leu 
    530                 535                 540                 


Arg Asp Asn Thr Pro Glu Asp Ala Arg Ile Leu Ala Trp Trp Asp Tyr 
545                 550                 555                 560 


Gly Tyr Gln Ile Thr Gly Ile Gly Asn Arg Thr Ser Leu Ala Asp Gly 
                565                 570                 575     


Asn Thr Trp Asn His Glu His Ile Ala Thr Ile Gly Lys Met Leu Thr 
            580                 585                 590         


Ser Pro Val Ala Glu Ala His Ser Leu Val Arg His Met Ala Asp Tyr 
        595                 600                 605             


Val Leu Ile Phe Ala Gly Asp Thr Tyr Phe Ser Asp Leu Asn Arg Ser 
    610                 615                 620                 


Pro His Met Ala Arg Ile Gly Asn Ser Val Tyr Arg Asp Ile Cys Pro 
625                 630                 635                 640 


His Asp Pro Leu Cys Ser Arg Phe Val Leu Gln Lys Arg Pro Lys Ala 
                645                 650                 655     


Ala Ala Ala Lys Arg Ser Arg His Val Ser Val Asp Glu Leu Glu Glu 
            660                 665                 670         


Glu Asp Asn Ala Glu His Val Val Tyr Glu Pro Ser Ser Leu Met Ala 
        675                 680                 685             


Lys Ser Leu Ile Tyr His Leu His Ser Ala Gly Val Val Thr Gly Val 
    690                 695                 700                 


Thr Leu Asn Glu Thr Leu Phe Gln His Val Phe Thr Ser Ala Gln Gly 
705                 710                 715                 720 


Leu Ile Arg Ile Phe Lys Val Met Asn Val Ser Glu Glu Ser Lys Lys 
                725                 730                 735     


Trp Val Ala Asp Pro Ala Asn Arg Val Cys His Pro Pro Gly Ser Trp 
            740                 745                 750         


Ile Cys Pro Gly Gln Tyr Pro Pro Ala Lys Glu Ile Gln Glu Met Leu 
        755                 760                 765             


Ala His Gln His Thr Asn Phe Lys Asp Leu Leu Asp Ala Met Asn Asp 
    770                 775                 780                 


Leu Glu Arg Glu Gln Ala Leu Asn Lys Glu 
785                 790                 


<210>  22
<211>  794
<212>  PRT
<213>  Leishmania infantum

<400>  22

Met Ser Ser Gln Thr Arg Ser Ile Ile Tyr Ser Ser Cys Phe Ala Val 
1               5                   10                  15      


Ala Met Ala Ile Ala Leu Pro Ile Ala Tyr Asp Met Arg Val Arg Ser 
            20                  25                  30          


Ile Gly Val Tyr Gly Tyr Leu Phe His Arg Ser Asp Pro Trp Phe Asn 
        35                  40                  45              


Tyr Arg Ala Ala Glu Tyr Met Ser Thr His Gly Trp Ser Ala Phe Phe 
    50                  55                  60                  


Ser Trp Phe Asp Tyr Met Ser Trp Tyr Pro Leu Gly Arg Pro Val Gly 
65                  70                  75                  80  


Ser Thr Thr Tyr Pro Gly Leu Gln Leu Thr Ala Val Ala Ile His Arg 
                85                  90                  95      


Ala Leu Ala Ala Ala Gly Met Pro Met Ser Leu Asn Asn Val Cys Val 
            100                 105                 110         


Leu Met Pro Ala Trp Phe Ser Leu Val Ser Ser Ala Met Val Ala Leu 
        115                 120                 125             


Leu Ala His Glu Leu Ser Gly Asn Met Ala Val Ala Ser Ile Ser Ser 
    130                 135                 140                 


Ile Leu Phe Ser Val Ile Pro Ala His Leu Met Arg Ser Met Ala Gly 
145                 150                 155                 160 


Glu Phe Asp Asn Glu Cys Ile Ala Val Ala Ala Met Leu Leu Thr Phe 
                165                 170                 175     


Tyr Cys Trp Val Arg Ser Leu Arg Thr Arg Ser Ser Trp Pro Ile Gly 
            180                 185                 190         


Val Leu Thr Gly Val Ala Tyr Gly Tyr Met Val Ala Ala Trp Gly Gly 
        195                 200                 205             


Tyr Ile Phe Val Leu Asn Met Val Ala Met His Ala Gly Ile Ser Ser 
    210                 215                 220                 


Met Val Asp Trp Ala Arg Asn Thr Tyr Asn Pro Ser Leu Leu Arg Ala 
225                 230                 235                 240 


Tyr Thr Leu Phe Tyr Val Val Gly Thr Ala Ile Ala Val Cys Val Pro 
                245                 250                 255     


Pro Val Gly Met Ser Pro Phe Lys Ser Leu Glu Gln Leu Gly Ala Leu 
            260                 265                 270         


Leu Val Leu Leu Phe Ile Phe Gly Gln Ser Val Cys Glu Ala Gln Arg 
        275                 280                 285             


Arg Arg Leu Glu Ile Ala Arg Phe Ser Lys Glu Gly Val Ala Leu Leu 
    290                 295                 300                 


Ile Arg Ile Tyr Ala Ala Phe Phe Val Gly Ile Val Ala Val Ala Thr 
305                 310                 315                 320 


Ile Ala Pro Ala Gly Phe Phe Lys Pro Leu Ser Leu Gln Ala Ser Ala 
                325                 330                 335     


Ile Ile Thr Gly Val Ser Arg Thr Gly Asn Thr Leu Val Asp Thr Leu 
            340                 345                 350         


Ile Ala Gln Asp Ala Ser Asn Leu Leu Ile Val Trp Gln Leu Phe Leu 
        355                 360                 365             


Phe Pro Val Phe Gly Trp Val Ala Gly Met Ser Ala Phe Leu Thr Glu 
    370                 375                 380                 


Leu Val Arg Asn Tyr Thr Tyr Thr Lys Ser Phe Met Leu Met Tyr Gly 
385                 390                 395                 400 


Val Val Gly Leu Tyr Phe Ala Ser Gln Ser Val Arg Met Met Val Met 
                405                 410                 415     


Met Ala Pro Val Ala Cys Ile Phe Thr Ala Leu Leu Phe Arg Trp Ala 
            420                 425                 430         


Leu Asp Tyr Leu Leu Gly Ser Leu Phe Trp Ala Glu Met Pro Pro Cys 
        435                 440                 445             


Phe Asp Thr Asp Ala Gln Arg Gly Arg Gln Gln Gln Thr Ala Glu Glu 
    450                 455                 460                 


Ala Glu Ala Glu Thr Lys Arg Lys Glu Glu Glu Tyr Asn Thr Met Gln 
465                 470                 475                 480 


Val Lys Lys Met Thr Thr Arg Met Leu Pro Phe Met Phe Leu Leu Leu 
                485                 490                 495     


Leu Phe Arg Leu Ser Gly Phe Ile Glu Asp Val Ala Ala Ile Ser Arg 
            500                 505                 510         


Glu Met Glu Ala Pro Gly Ile Val Phe Pro Ser Gly Gln Val Gln Gly 
        515                 520                 525             


Val Ser Glu Lys Lys Val Asp Asp Tyr Tyr Ser Gly Tyr Leu Tyr Leu 
    530                 535                 540                 


Arg Asp Asn Thr Pro Glu Asp Ala Arg Ile Leu Ala Trp Trp Asp Tyr 
545                 550                 555                 560 


Gly Tyr Gln Ile Thr Gly Ile Gly Asn Arg Thr Ser Leu Ala Asp Gly 
                565                 570                 575     


Asn Thr Trp Asn His Glu His Ile Ala Thr Ile Gly Lys Met Leu Thr 
            580                 585                 590         


Ser Pro Val Ala Glu Ala His Ser Leu Val Arg His Met Ala Asp Tyr 
        595                 600                 605             


Val Leu Ile Phe Ala Gly Asp Thr Tyr Phe Ser Asp Leu Asn Arg Ser 
    610                 615                 620                 


Pro His Met Ala Arg Ile Gly Asn Ser Val Tyr Arg Asp Ile Cys Pro 
625                 630                 635                 640 


His Asp Pro Leu Cys Ser Arg Phe Val Leu Gln Lys Arg Pro Lys Ala 
                645                 650                 655     


Ala Ala Ala Lys Arg Ser Arg His Val Ser Val Asp Glu Leu Glu Glu 
            660                 665                 670         


Glu Asp Asn Ala Glu His Val Val Tyr Glu Pro Ser Ser Leu Met Ala 
        675                 680                 685             


Lys Ser Leu Ile Tyr His Leu His Ser Ala Gly Val Val Lys Gly Val 
    690                 695                 700                 


Thr Leu Asn Glu Thr Leu Phe Gln His Val Phe Thr Ser Ala Gln Gly 
705                 710                 715                 720 


Leu Ile Arg Ile Phe Lys Val Met Asn Val Ser Glu Glu Ser Lys Lys 
                725                 730                 735     


Trp Val Ala Asp Pro Ala Asn Arg Val Cys His Pro Pro Gly Ser Trp 
            740                 745                 750         


Ile Cys Pro Gly Gln Tyr Pro Pro Ala Lys Glu Ile Gln Glu Met Leu 
        755                 760                 765             


Ala His Gln His Thr Asn Phe Lys Asp Leu Leu Asp Ala Met Asn Asp 
    770                 775                 780                 


Leu Glu Arg Glu Gln Ala Leu Asn Lys Glu 
785                 790                 


<210>  23
<211>  794
<212>  PRT
<213>  Leishmania Mexicana

<400>  23

Met Ser Ser Gln Thr Arg Ser Leu Ile Tyr Ser Ser Cys Phe Ala Val 
1               5                   10                  15      


Val Met Ala Ile Gly Leu Ser Ile Ala Tyr Asp Met Arg Val Arg Ser 
            20                  25                  30          


Ile Gly Val Tyr Gly Tyr Leu Phe His Ser Ser Asp Pro Trp Phe Asn 
        35                  40                  45              


Tyr Arg Ala Ala Glu Tyr Met Ser Thr His Gly Trp Ser Ala Phe Phe 
    50                  55                  60                  


Ser Trp Phe Asp Tyr Met Ser Trp Tyr Pro Leu Gly Arg Pro Val Gly 
65                  70                  75                  80  


Ser Thr Thr Tyr Pro Gly Leu Gln Phe Thr Ala Val Ala Ile His Arg 
                85                  90                  95      


Ala Leu Ala Ala Ala Gly Met Pro Met Ser Leu Asn Asp Val Cys Val 
            100                 105                 110         


Leu Ile Pro Ala Trp Phe Ser Leu Leu Ser Ser Ala Met Val Ala Leu 
        115                 120                 125             


Leu Ala His Glu Ile Ser Gly Asn Met Ala Val Ala Ser Val Ser Ser 
    130                 135                 140                 


Ile Leu Phe Ser Val Val Pro Ala His Leu Met Arg Ser Met Ala Gly 
145                 150                 155                 160 


Glu Phe Asp Asn Glu Cys Ile Ala Val Thr Ala Met Leu Leu Thr Phe 
                165                 170                 175     


Tyr Cys Trp Val Arg Ser Leu Arg Thr Arg Ser Ser Trp Pro Ile Gly 
            180                 185                 190         


Val Leu Thr Gly Val Ala Tyr Gly Tyr Met Val Ala Ala Trp Gly Gly 
        195                 200                 205             


Tyr Ile Phe Val Leu Asn Met Val Ala Met His Ala Gly Ile Ser Ser 
    210                 215                 220                 


Met Val Asp Trp Ala Arg Asn Thr Tyr Asn Pro Ser Leu Leu Arg Ala 
225                 230                 235                 240 


Tyr Thr Leu Phe Tyr Val Val Gly Thr Ala Ile Ala Val Cys Val Pro 
                245                 250                 255     


Pro Val Gly Met Ser Pro Phe Lys Ser Leu Glu Gln Leu Gly Ala Leu 
            260                 265                 270         


Leu Val Leu Leu Phe Ile Phe Gly Gln Ala Leu Cys Glu Ala Gln Arg 
        275                 280                 285             


Ser Arg Leu Gly Ile Glu Arg Phe Ser Lys Glu Gly Val Ala Leu Leu 
    290                 295                 300                 


Ile Arg Ile Tyr Ala Ala Phe Phe Val Gly Ile Val Ala Val Ala Ala 
305                 310                 315                 320 


Val Ala Pro Ala Gly Phe Phe Lys Pro Leu Ser Leu Gln Ala Thr Ala 
                325                 330                 335     


Ile Ile Ala Gly Val Ser Arg Thr Gly Asn Thr Leu Val Asp Ile Leu 
            340                 345                 350         


Ile Ala Gln Asp Ala Ser Asn Leu Leu Ile Val Trp Gln Leu Phe Leu 
        355                 360                 365             


Phe Pro Leu Leu Gly Trp Val Val Gly Met Ser Leu Phe Leu Thr Glu 
    370                 375                 380                 


Leu Val Arg Asn Phe Thr Tyr Ala Lys Ser Phe Ile Leu Met Tyr Gly 
385                 390                 395                 400 


Val Val Gly Ile Tyr Phe Ala Ser Gln Ser Val Arg Met Met Val Met 
                405                 410                 415     


Met Ala Pro Val Ala Cys Ile Phe Thr Ala Leu Leu Phe Arg Trp Thr 
            420                 425                 430         


Leu Asp Tyr Leu Leu Gly Ser Phe Phe Trp Ala Glu Met Pro Leu Ser 
        435                 440                 445             


Leu Asp Thr Asp Ala Gln Arg Gly Arg Gln Gln Gln Thr Ala Glu Glu 
    450                 455                 460                 


Ala Glu Ala Glu Thr Lys Arg Lys Glu Glu Glu Tyr Asn Thr Met Gln 
465                 470                 475                 480 


Val Lys Lys Met Thr Val Arg Met Val Pro Phe Met Ile Leu Leu Leu 
                485                 490                 495     


Leu Phe Arg Leu Ser Gly Phe Ile Glu Asp Val Ala Ala Ile Ser Arg 
            500                 505                 510         


Glu Met Glu Ser Pro Gly Ile Ile Phe Pro Arg Gly Gln Val Gln Gly 
        515                 520                 525             


Met Pro Glu Asp Lys Val Asp Asp Tyr Tyr Ala Gly Tyr Leu Tyr Leu 
    530                 535                 540                 


Arg Glu Asn Thr Pro Glu Asp Ala Arg Ile Leu Ala Trp Trp Asp Tyr 
545                 550                 555                 560 


Gly Tyr Gln Ile Thr Gly Ile Gly Asn Arg Thr Ser Leu Ala Asp Gly 
                565                 570                 575     


Asn Thr Trp Asn His Glu His Ile Ala Thr Ile Gly Lys Met Leu Thr 
            580                 585                 590         


Ser Pro Val Ala Glu Ala His Ser Leu Val Arg His Met Ala Asp Tyr 
        595                 600                 605             


Val Leu Ile Phe Ser Gly Asp Lys Tyr Phe Ser Asp Leu Asn Arg Ser 
    610                 615                 620                 


Pro Met Met Ala Arg Ile Gly Asn Ser Val Tyr Arg Asp Ile Cys Pro 
625                 630                 635                 640 


Asn Asp Pro Leu Cys Ser Gln Phe Val Leu Gln Lys Arg Arg Lys Val 
                645                 650                 655     


Ala Ala Ala Lys Arg Ser Arg His Val Thr Val Asn Glu Gln Glu Glu 
            660                 665                 670         


Asp Asp Asn Pro Glu Ser Val Val Tyr Glu Pro Ser Ser Leu Met Ala 
        675                 680                 685             


Lys Ser Leu Ile Tyr His Leu His Ser Thr Gly Val Val Glu Gly Val 
    690                 695                 700                 


Met Leu Asp Glu Thr Leu Phe Gln Asn Val Phe Thr Ser Thr Gln Gly 
705                 710                 715                 720 


Phe Met Arg Ile Phe Lys Val Met Asn Val Ser Ala Glu Ser Lys Lys 
                725                 730                 735     


Trp Val Ala Asp Pro Ala Asn Arg Val Cys Arg Pro Pro Gly Ser Trp 
            740                 745                 750         


Ile Cys Pro Gly Gln Tyr Pro Pro Ala Lys Glu Ile Gln Glu Met Leu 
        755                 760                 765             


Ala His Gln Asn Thr Asn Phe Lys Asp Leu Leu Asp Ala Met Asn Asp 
    770                 775                 780                 


Leu Glu Gln Ala Gln Ala Leu Asn Lys Val 
785                 790                 


<210>  24
<211>  823
<212>  PRT
<213>  Leishmania braziliensis

<400>  24

Met Val Thr Glu Arg Gly Ala Ala Thr Pro Ser Thr Ala Ala Ser Gly 
1               5                   10                  15      


Glu Ala Pro Ser Glu Thr Leu Leu Leu Gly Glu Tyr Lys Val Ser Leu 
            20                  25                  30          


His Ala Arg Ser Thr Ile Tyr Thr Ala Cys Phe Ala Val Pro Met Ala 
        35                  40                  45              


Ile Leu Phe Pro Ile Ala Tyr Lys Met Arg Val Arg Ser Ile Asp Val 
    50                  55                  60                  


Tyr Gly Tyr Leu Phe His Arg Asn Asp Pro Trp Phe Asn Tyr Arg Ala 
65                  70                  75                  80  


Ala Glu Tyr Met Ser Ala His Gly Trp Ser Ala Phe Phe Ser Trp Phe 
                85                  90                  95      


Asp Tyr Met Ser Trp Tyr Pro Leu Gly Arg Pro Val Gly Thr Thr Thr 
            100                 105                 110         


Tyr Pro Gly Leu Gln Leu Thr Ala Val Ala Ile His Arg Ala Leu Ala 
        115                 120                 125             


Ala Ala Gly Val Pro Met Ser Leu Asn Asn Val Cys Val Leu Ile Pro 
    130                 135                 140                 


Ala Trp Phe Ser Leu Val Ser Ser Ala Met Val Ala Leu Leu Ala His 
145                 150                 155                 160 


Glu Met Thr Gly Asn Met Ala Thr Ser Ser Ile Ser Ser Ile Leu Phe 
                165                 170                 175     


Ser Val Val Pro Ala His Leu Met Arg Ser Met Ala Gly Glu Phe Asp 
            180                 185                 190         


Asn Glu Cys Ile Ala Val Ala Ala Met Leu Leu Thr Phe Tyr Leu Trp 
        195                 200                 205             


Val Arg Ser Leu Arg Thr Arg Cys Ser Trp Pro Ile Gly Ile Leu Thr 
    210                 215                 220                 


Gly Ile Ala Tyr Gly Tyr Met Val Ala Ala Trp Gly Gly Tyr Ile Phe 
225                 230                 235                 240 


Val Leu Asn Met Val Ala Met His Ala Gly Ile Ser Ser Met Val Asp 
                245                 250                 255     


Trp Ala Arg Asn Thr Tyr Asn Pro Ser Leu Leu Arg Ala Tyr Ala Leu 
            260                 265                 270         


Phe Tyr Val Val Gly Thr Ala Ile Ala Thr Arg Val Pro Pro Val Gly 
        275                 280                 285             


Met Ser Pro Phe Arg Ser Leu Glu Gln Leu Gly Ala Leu Val Val Leu 
    290                 295                 300                 


Leu Phe Leu Cys Gly Leu Gln Ala Cys Glu Thr Gln Arg Ser Arg Leu 
305                 310                 315                 320 


Gly Val Glu Arg Phe Ser Thr Glu Gly Val Ser Leu Leu Val Arg Ile 
                325                 330                 335     


Tyr Ala Ala Phe Phe Val Gly Ile Val Ala Val Val Ala Met Ala Pro 
            340                 345                 350         


Ala Gly Phe Phe Lys Pro Leu Ser Leu Gln Ala His Ala Met Ile Ala 
        355                 360                 365             


Gly Ala Gln Pro Thr Gly Asn Thr Leu Val Asp Met Leu Ile Ala Lys 
    370                 375                 380                 


Asp Ala Ser Ser Leu Leu Val Ala Trp Glu Leu Leu Leu Phe Pro Phe 
385                 390                 395                 400 


Phe Gly Trp Met Val Gly Met Gly Ala Phe Leu Thr Glu Leu Val Gln 
                405                 410                 415     


Ser Phe Thr Tyr Thr Lys Ser Phe Met Leu Met Tyr Gly Ala Val Gly 
            420                 425                 430         


Met Tyr Phe Ala Ser Gln Ser Val Arg Met Met Val Met Met Ala Pro 
        435                 440                 445             


Val Ala Cys Ile Phe Thr Ala Leu Leu Phe Cys Leu Ala Leu Asp Tyr 
    450                 455                 460                 


Ala Leu Gly Ala Leu Phe Trp Ala Glu Ile Pro Pro Ser Ile Asp Ser 
465                 470                 475                 480 


Asp Ala Gln Gln Glu Leu His Gln Gln Thr Ala Glu Ala Ala Lys Thr 
                485                 490                 495     


Lys Lys Arg Lys Gln Glu Glu Tyr Thr Thr Met Gln Val Lys Met Ile 
            500                 505                 510         


Ser Val Arg Met Met Pro Leu Met Leu Leu Val Leu Leu Phe Arg Phe 
        515                 520                 525             


Ser Gly Phe Ile Glu Asp Val Ala Ala Ile Ser Arg Glu Ile Glu Val 
    530                 535                 540                 


Pro Gly Ile Val Phe Pro Gly Ser Met Val Gln Gly Leu Ser Asp Asp 
545                 550                 555                 560 


Met Ile Asp Asp Tyr Tyr Ala Gly Tyr Leu Tyr Leu Arg Asp Asn Thr 
                565                 570                 575     


Pro Ala Asp Ala Arg Val Leu Ser Trp Trp Asp Tyr Gly Tyr Gln Ile 
            580                 585                 590         


Thr Gly Ile Gly Asn Arg Thr Ser Leu Ala Asp Gly Asn Thr Trp Asn 
        595                 600                 605             


His Glu His Ile Ala Thr Ile Gly Lys Met Leu Thr Ser Pro Val Ala 
    610                 615                 620                 


Glu Ala His Ser Leu Val Arg His Met Ala Asp Tyr Val Leu Ile Phe 
625                 630                 635                 640 


Ala Gly Asp Met His Phe Ser Asp Leu Ile Asn Ser Pro Met Met Ala 
                645                 650                 655     


Arg Ile Gly Asn Ser Val Tyr His Asp Ile Cys Pro Asn Asp Pro Leu 
            660                 665                 670         


Cys Ser Arg Phe Val Phe Gln Glu Lys Arg Lys Ile Ala Pro Ala Arg 
        675                 680                 685             


Ser Gly Arg His Ile Asn Leu Ala Lys Leu Gly Asp Asp Glu Glu Glu 
    690                 695                 700                 


Thr Gln Asn Val Glu Tyr Glu Pro Ser Pro Leu Met Ala Lys Ser Leu 
705                 710                 715                 720 


Ile Tyr His Leu His Ser Ala Gly Val Lys Glu Gly Val Thr Leu Asn 
                725                 730                 735     


Asp Lys Leu Phe Gln His Val Tyr Thr Ser Ala His Gly Leu Met Arg 
            740                 745                 750         


Ile Phe Lys Val Met Asn Val Ser Ala Glu Ser Lys Lys Trp Val Ala 
        755                 760                 765             


Asp Pro Ala Asn Arg Val Cys His Pro Pro Gly Ser Trp Ile Cys Pro 
    770                 775                 780                 


Gly Gln Tyr Pro Pro Ala Lys Glu Ile Gln Glu Met Leu Ala His Arg 
785                 790                 795                 800 


Tyr Thr Ser Leu Lys Asp Leu Val Asp Ser Met Ser Asp Ser Glu Arg 
                805                 810                 815     


Glu Gly Thr Leu Asn Gly Glu 
            820             


<210>  25
<211>  795
<212>  PRT
<213>  Artificial

<220>
<223>  Leishmania STT3 consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (133)..(134)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (139)..(140)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (150)..(150)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (170)..(170)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (187)..(187)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (193)..(193)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (203)..(203)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (242)..(242)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (253)..(254)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (264)..(264)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (273)..(273)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (276)..(276)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (278)..(279)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (281)..(283)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (286)..(286)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (289)..(289)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (292)..(294)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (296)..(296)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (298)..(298)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (302)..(302)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (305)..(305)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (308)..(308)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (319)..(321)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (335)..(335)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (337)..(337)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (339)..(339)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (341)..(343)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (351)..(351)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (353)..(353)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (355)..(355)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (362)..(363)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (365)..(365)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (367)..(367)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (371)..(372)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (375)..(376)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (379)..(380)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (383)..(383)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (386)..(389)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (392)..(392)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (396)..(396)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (401)..(401)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (404)..(404)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (430)..(432)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (436)..(436)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (439)..(440)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (445)..(445)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (447)..(449)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (451)..(451)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (455)..(458)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (464)..(469)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (473)..(473)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (477)..(477)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (483)..(486)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (489)..(489)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (491)..(491)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (493)..(493)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (495)..(495)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (500)..(500)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (513)..(514)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (516)..(516)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (520)..(520)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (523)..(525)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (529)..(534)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (539)..(539)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (546)..(547)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (550)..(550)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (554)..(554)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (556)..(556)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (612)..(613)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (616)..(617)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (622)..(623)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (626)..(626)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (636)..(636)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (641)..(641)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (647)..(647)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (650)..(650)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (652)..(654)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (656)..(656)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (658)..(658)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (660)..(662)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (665)..(681)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (686)..(686)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (688)..(688)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (699)..(699)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (702)..(703)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (706)..(706)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (708)..(710)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (714)..(714)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (716)..(716)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (719)..(720)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (722)..(723)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (733)..(733)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (742)..(742)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (748)..(748)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (772)..(773)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (775)..(776)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (780)..(780)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (782)..(795)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Xaa Xaa Xaa Xaa Xaa Xaa Ser Thr Xaa Tyr Thr Xaa Xaa Phe Ala Val 
1               5                   10                  15      


Pro Met Ala Ile Xaa Xaa Xaa Ile Ala Tyr Xaa Met Arg Val Arg Ser 
            20                  25                  30          


Ile Xaa Val Tyr Gly Tyr Leu Phe His Xaa Xaa Asp Pro Trp Phe Asn 
        35                  40                  45              


Tyr Arg Ala Ala Glu Tyr Met Ser Xaa His Gly Trp Ser Ala Phe Phe 
    50                  55                  60                  


Ser Trp Phe Asp Tyr Met Ser Trp Tyr Pro Leu Gly Arg Pro Val Gly 
65                  70                  75                  80  


Xaa Thr Thr Tyr Pro Gly Leu Gln Xaa Thr Ala Val Ala Ile His Arg 
                85                  90                  95      


Ala Leu Ala Ala Ala Gly Xaa Pro Met Ser Leu Asn Xaa Val Cys Val 
            100                 105                 110         


Leu Xaa Pro Ala Trp Phe Ser Leu Xaa Ser Ser Ala Met Xaa Ala Leu 
        115                 120                 125             


Leu Ala His Glu Xaa Xaa Gly Asn Met Ala Xaa Xaa Ser Xaa Ser Ser 
    130                 135                 140                 


Ile Leu Phe Ser Val Xaa Pro Ala His Leu Met Arg Ser Met Ala Gly 
145                 150                 155                 160 


Glu Phe Asp Asn Glu Cys Ile Ala Val Xaa Ala Met Leu Leu Thr Phe 
                165                 170                 175     


Tyr Xaa Trp Val Arg Ser Leu Arg Thr Arg Xaa Ser Trp Pro Ile Gly 
            180                 185                 190         


Xaa Leu Thr Gly Xaa Ala Tyr Gly Tyr Met Xaa Ala Ala Trp Gly Gly 
        195                 200                 205             


Tyr Ile Phe Val Leu Asn Met Val Ala Met His Ala Gly Ile Ser Ser 
    210                 215                 220                 


Met Val Asp Trp Ala Arg Asn Thr Tyr Asn Pro Ser Leu Leu Arg Ala 
225                 230                 235                 240 


Tyr Xaa Leu Phe Tyr Val Val Gly Thr Ala Ile Ala Xaa Xaa Val Pro 
                245                 250                 255     


Pro Val Gly Met Ser Pro Phe Xaa Arg Ser Leu Glu Gln Leu Gly Ala 
            260                 265                 270         


Xaa Val Val Xaa Leu Xaa Xaa Cys Xaa Xaa Xaa Ala Cys Xaa Thr Gln 
        275                 280                 285             


Xaa Ser Arg Xaa Xaa Xaa Glu Xaa Phe Xaa Thr Glu Gly Xaa Ser Leu 
    290                 295                 300                 


Xaa Arg Ile Xaa Ala Ala Phe Phe Val Gly Ile Val Ala Val Xaa Xaa 
305                 310                 315                 320 


Xaa Ala Pro Ala Gly Phe Phe Lys Pro Leu Ser Leu Gln Ala Xaa Ala 
                325                 330                 335     


Xaa Ile Xaa Gly Xaa Xaa Xaa Thr Gly Asn Thr Leu Val Asp Xaa Leu 
            340                 345                 350         


Xaa Ala Xaa Asp Ala Ser Xaa Leu Leu Xaa Xaa Trp Xaa Leu Xaa Leu 
        355                 360                 365             


Phe Pro Xaa Xaa Gly Trp Xaa Xaa Gly Met Xaa Xaa Phe Leu Xaa Glu 
    370                 375                 380                 


Leu Xaa Xaa Xaa Xaa Thr Tyr Xaa Lys Ser Phe Xaa Leu Met Tyr Gly 
385                 390                 395                 400 


Xaa Val Gly Xaa Tyr Phe Ala Ser Gln Ser Val Arg Met Met Val Met 
                405                 410                 415     


Met Ala Pro Val Ala Cys Ile Phe Thr Ala Leu Leu Phe Xaa Xaa Xaa 
            420                 425                 430         


Leu Asp Tyr Xaa Leu Gly Xaa Xaa Phe Trp Ala Glu Xaa Pro Xaa Xaa 
        435                 440                 445             


Xaa Asp Xaa Asp Ala Gln Xaa Xaa Xaa Xaa Gln Gln Thr Ala Glu Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Lys Arg Lys Xaa Glu Glu Tyr Xaa Thr Met Gln 
465                 470                 475                 480 


Val Lys Xaa Xaa Xaa Xaa Arg Met Xaa Pro Xaa Met Xaa Leu Xaa Leu 
                485                 490                 495     


Leu Phe Arg Xaa Ser Gly Phe Ile Glu Asp Val Ala Ala Ile Ser Arg 
            500                 505                 510         


Xaa Xaa Glu Xaa Pro Gly Ile Xaa Phe Pro Xaa Xaa Xaa Val Gln Gly 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Asp Asp Tyr Tyr Xaa Gly Tyr Leu Tyr Leu 
    530                 535                 540                 


Arg Xaa Xaa Thr Pro Xaa Asp Ala Arg Xaa Leu Xaa Trp Trp Asp Tyr 
545                 550                 555                 560 


Gly Tyr Gln Ile Thr Gly Ile Gly Asn Arg Thr Ser Leu Ala Asp Gly 
                565                 570                 575     


Asn Thr Trp Asn His Glu His Ile Ala Thr Ile Gly Lys Met Leu Thr 
            580                 585                 590         


Ser Pro Val Ala Glu Ala His Ser Leu Val Arg His Met Ala Asp Tyr 
        595                 600                 605             


Val Leu Ile Xaa Xaa Gly Asp Xaa Xaa Phe Ser Asp Leu Xaa Xaa Ser 
    610                 615                 620                 


Pro Xaa Met Ala Arg Ile Gly Asn Ser Val Tyr Xaa Asp Ile Cys Pro 
625                 630                 635                 640 


Xaa Asp Pro Leu Cys Ser Xaa Phe Val Xaa Gln Xaa Xaa Xaa Lys Xaa 
                645                 650                 655     


Ala Xaa Ala Xaa Xaa Xaa Arg His Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Glu Pro Ser Xaa Leu Xaa 
        675                 680                 685             


Ala Lys Ser Leu Ile Tyr His Leu His Ser Xaa Gly Val Xaa Xaa Gly 
    690                 695                 700                 


Val Xaa Leu Xaa Xaa Xaa Leu Phe Gln Xaa Val Xaa Thr Ser Xaa Xaa 
705                 710                 715                 720 


Gly Xaa Xaa Arg Ile Phe Lys Val Met Asn Val Ser Xaa Glu Ser Lys 
                725                 730                 735     


Lys Trp Val Ala Asp Xaa Ala Asn Arg Val Cys Xaa Pro Pro Gly Ser 
            740                 745                 750         


Trp Ile Cys Pro Gly Gln Tyr Pro Pro Ala Lys Glu Ile Gln Glu Met 
        755                 760                 765             


Leu Ala His Xaa Xaa Thr Xaa Xaa Lys Asp Leu Xaa Asp Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795 


<210>  26
<211>  718
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  26

Met Gly Ser Asp Arg Ser Cys Val Leu Ser Val Phe Gln Thr Ile Leu 
1               5                   10                  15      


Lys Leu Val Ile Phe Val Ala Ile Phe Gly Ala Ala Ile Ser Ser Arg 
            20                  25                  30          


Leu Phe Ala Val Ile Lys Phe Glu Ser Ile Ile His Glu Phe Asp Pro 
        35                  40                  45              


Trp Phe Asn Tyr Arg Ala Thr Lys Tyr Leu Val Asn Asn Ser Phe Tyr 
    50                  55                  60                  


Lys Phe Leu Asn Trp Phe Asp Asp Arg Thr Trp Tyr Pro Leu Gly Arg 
65                  70                  75                  80  


Val Thr Gly Gly Thr Leu Tyr Pro Gly Leu Met Thr Thr Ser Ala Phe 
                85                  90                  95      


Ile Trp His Ala Leu Arg Asn Trp Leu Gly Leu Pro Ile Asp Ile Arg 
            100                 105                 110         


Asn Val Cys Val Leu Phe Ala Pro Leu Phe Ser Gly Val Thr Ala Trp 
        115                 120                 125             


Ala Thr Tyr Glu Phe Thr Lys Glu Ile Lys Asp Ala Ser Ala Gly Leu 
    130                 135                 140                 


Leu Ala Ala Gly Phe Ile Ala Ile Val Pro Gly Tyr Ile Ser Arg Ser 
145                 150                 155                 160 


Val Ala Gly Ser Tyr Asp Asn Glu Ala Ile Ala Ile Thr Leu Leu Met 
                165                 170                 175     


Val Thr Phe Met Phe Trp Ile Lys Ala Gln Lys Thr Gly Ser Ile Met 
            180                 185                 190         


His Ala Thr Cys Ala Ala Leu Phe Tyr Phe Tyr Met Val Ser Ala Trp 
        195                 200                 205             


Gly Gly Tyr Val Phe Ile Thr Asn Leu Ile Pro Leu His Val Phe Leu 
    210                 215                 220                 


Leu Ile Leu Met Gly Arg Tyr Ser Ser Lys Leu Tyr Ser Ala Tyr Thr 
225                 230                 235                 240 


Thr Trp Tyr Ala Ile Gly Thr Val Ala Ser Met Gln Ile Pro Phe Val 
                245                 250                 255     


Gly Phe Leu Pro Ile Arg Ser Asn Asp His Met Ala Ala Leu Gly Val 
            260                 265                 270         


Phe Gly Leu Ile Gln Ile Val Ala Phe Gly Asp Phe Val Lys Gly Gln 
        275                 280                 285             


Ile Ser Thr Ala Lys Phe Lys Val Ile Met Met Val Ser Leu Phe Leu 
    290                 295                 300                 


Ile Leu Val Leu Gly Val Val Gly Leu Ser Ala Leu Thr Tyr Met Gly 
305                 310                 315                 320 


Leu Ile Ala Pro Trp Thr Gly Arg Phe Tyr Ser Leu Trp Asp Thr Asn 
                325                 330                 335     


Tyr Ala Lys Ile His Ile Pro Ile Ile Ala Ser Val Ser Glu His Gln 
            340                 345                 350         


Pro Val Ser Trp Pro Ala Phe Phe Phe Asp Thr His Phe Leu Ile Trp 
        355                 360                 365             


Leu Phe Pro Ala Gly Val Phe Leu Leu Phe Leu Asp Leu Lys Asp Glu 
    370                 375                 380                 


His Val Phe Val Ile Ala Tyr Ser Val Leu Cys Ser Tyr Phe Ala Gly 
385                 390                 395                 400 


Val Met Val Arg Leu Met Leu Thr Leu Thr Pro Val Ile Cys Val Ser 
                405                 410                 415     


Ala Ala Val Ala Leu Ser Lys Ile Phe Asp Ile Tyr Leu Asp Phe Lys 
            420                 425                 430         


Thr Ser Asp Arg Lys Tyr Ala Ile Lys Pro Ala Ala Leu Leu Ala Lys 
        435                 440                 445             


Leu Ile Val Ser Gly Ser Phe Ile Phe Tyr Leu Tyr Leu Phe Val Phe 
    450                 455                 460                 


His Ser Thr Trp Val Thr Arg Thr Ala Tyr Ser Ser Pro Ser Val Val 
465                 470                 475                 480 


Leu Pro Ser Gln Thr Pro Asp Gly Lys Leu Ala Leu Ile Asp Asp Phe 
                485                 490                 495     


Arg Glu Ala Tyr Tyr Trp Leu Arg Met Asn Ser Asp Glu Asp Ser Lys 
            500                 505                 510         


Val Ala Ala Trp Trp Asp Tyr Gly Tyr Gln Ile Gly Gly Met Ala Asp 
        515                 520                 525             


Arg Thr Thr Leu Val Asp Asn Asn Thr Trp Asn Asn Thr His Ile Ala 
    530                 535                 540                 


Ile Val Gly Lys Ala Met Ala Ser Pro Glu Glu Lys Ser Tyr Glu Ile 
545                 550                 555                 560 


Leu Lys Glu His Asp Val Asp Tyr Val Leu Val Ile Phe Gly Gly Leu 
                565                 570                 575     


Ile Gly Phe Gly Gly Asp Asp Ile Asn Lys Phe Leu Trp Met Ile Arg 
            580                 585                 590         


Ile Ser Glu Gly Ile Trp Pro Glu Glu Ile Lys Glu Arg Tyr Phe Tyr 
        595                 600                 605             


Thr Ala Glu Gly Glu Tyr Arg Val Asp Ala Arg Ala Ser Glu Thr Met 
    610                 615                 620                 


Arg Asn Ser Leu Leu Tyr Lys Met Ser Tyr Lys Asp Phe Pro Gln Leu 
625                 630                 635                 640 


Phe Asn Gly Gly Gln Ala Thr Asp Arg Val Arg Gln Gln Met Ile Thr 
                645                 650                 655     


Pro Leu Asp Val Pro Pro Leu Asp Tyr Phe Asp Glu Val Phe Thr Ser 
            660                 665                 670         


Glu Asn Trp Met Val Arg Ile Tyr Gln Leu Lys Lys Asp Asp Ala Gln 
        675                 680                 685             


Gly Arg Thr Leu Arg Asp Val Gly Glu Leu Thr Arg Ser Ser Thr Lys 
    690                 695                 700                 


Thr Arg Arg Ser Ile Lys Arg Pro Glu Leu Gly Leu Arg Val 
705                 710                 715             


<210>  27
<211>  2157
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  27
atgggatccg accggtcgtg tgttttgtct gtgtttcaga ccatcctcaa gctcgtcatc       60

ttcgtggcga tttttggggc tgccatatca tcacgtttgt ttgcagtcat caaatttgag      120

tctattatcc atgaattcga cccctggttc aattataggg ctaccaaata tctcgtcaac      180

aattcgtttt acaagttttt gaactggttt gacgaccgta cctggtaccc cctcggaagg      240

gttactggag ggactttata tcctggtttg atgacgacta gtgcgttcat ctggcacgcc      300

ctgcgcaact ggttgggctt gcccattgac atcagaaacg tttgtgtgct atttgcgcca      360

ctattttctg gggtcaccgc ctgggcgact tacgaattta cgaaagagat taaagatgcc      420

agcgctgggc ttttggctgc tggttttata gccattgtcc ccggttatat atctagatca      480

gtggcggggt cctacgataa tgaggccatt gccattacac tattaatggt cactttcatg      540

ttttggatta aggcccaaaa gactggctct atcatgcacg caacgtgtgc agctttattc      600

tacttctaca tggtgtcggc ttggggtgga tacgtgttca tcaccaactt gatcccactc      660

catgtctttt tgctgatttt gatgggcaga tattcgtcca aactgtattc tgcctacacc      720

acttggtacg ctattggaac tgttgcatcc atgcagatcc catttgtcgg tttcctacct      780

atcaggtcta acgaccacat ggccgcattg ggtgttttcg gtttgattca gattgtcgcc      840

ttcggtgact tcgtgaaggg ccaaatcagc acagctaagt ttaaagtcat catgatggtt      900

tctctgtttt tgatcttggt ccttggtgtg gtcggacttt ctgccttgac ctatatgggg      960

ttgattgccc cttggactgg tagattttat tcgttatggg ataccaacta cgcaaagatc     1020

cacattccta tcattgcctc cgtttccgaa catcaacccg tttcgtggcc cgctttcttc     1080

tttgataccc actttttgat ctggctattc cccgccggtg tattcctact attcctcgac     1140

ttgaaagacg agcacgtttt tgtcatcgct tactccgttc tgtgttcgta ctttgccggt     1200

gttatggtta gattgatgtt gactttgaca ccagtcatct gtgtgtccgc cgccgtcgca     1260

ttgtccaaga tatttgacat ctacctggat ttcaagacaa gtgaccgcaa atacgccatc     1320

aaacctgcgg cactactggc caaattgatt gtttccggat cattcatctt ttatttgtat     1380

cttttcgtct tccattctac ttgggtaaca agaactgcat actcttctcc ttctgttgtt     1440

ttgccatcac aaaccccaga tggtaaattg gcgttgatcg acgacttcag ggaagcgtac     1500

tattggttaa gaatgaactc tgatgaggac agtaaggttg cagcgtggtg ggattacggt     1560

taccaaattg gtggcatggc agacagaacc actttagtcg ataacaacac gtggaacaat     1620

actcacatcg ccatcgttgg taaagccatg gcttcccctg aagagaaatc ttacgaaatt     1680

ctaaaagagc atgatgtcga ttatgtcttg gtcatctttg gtggtctaat tgggtttggt     1740

ggtgatgaca tcaacaaatt cttgtggatg atcagaatta gcgagggaat ctggccagaa     1800

gagataaaag agcgttattt ctataccgca gagggagaat acagagtaga tgcaagggct     1860

tctgagacca tgaggaactc gctactttac aagatgtcct acaaagattt cccacaatta     1920

ttcaatggtg gccaagccac tgacagagtg cgtcaacaaa tgatcacacc attagacgtc     1980

ccaccattag actacttcga cgaagttttt acttccgaaa actggatggt tagaatatat     2040

caattgaaga aggatgatgc ccaaggtaga actttgaggg acgttggtga gttaaccagg     2100

tcttctacga aaaccagaag gtccataaag agacctgaat taggcttgag agtctaa        2157


<210>  28
<211>  749
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  28

Met Ala Asn Ser Ala Thr Ile Thr Ser Lys Lys Gly Val Lys Ser His 
1               5                   10                  15      


Gln Lys Asp Trp Lys Ile Pro Leu Lys Val Leu Ile Leu Ile Cys Ile 
            20                  25                  30          


Ala Val Ala Ser Val Ser Ser Arg Leu Phe Ser Val Ile Arg Tyr Glu 
        35                  40                  45              


Ser Ile Ile His Glu Phe Asp Pro Trp Phe Asn Phe Arg Ala Ser Lys 
    50                  55                  60                  


Ile Leu Val Glu Gln Gly Phe Tyr Asn Phe Leu Asn Trp Phe Asp Glu 
65                  70                  75                  80  


Arg Ser Trp Tyr Pro Leu Gly Arg Val Ala Gly Gly Thr Leu Tyr Pro 
                85                  90                  95      


Gly Leu Met Val Thr Ser Gly Ile Ile Phe Lys Val Leu His Leu Leu 
            100                 105                 110         


Arg Ile Asn Val Asn Ile Arg Asp Val Cys Val Leu Leu Ala Pro Ala 
        115                 120                 125             


Phe Ser Gly Ile Thr Ala Ile Ala Thr Tyr Tyr Leu Ala Arg Glu Leu 
    130                 135                 140                 


Lys Ser Asp Ala Cys Gly Leu Leu Ala Ala Ala Phe Met Gly Ile Ala 
145                 150                 155                 160 


Pro Gly Tyr Thr Ser Arg Ser Val Ala Gly Ser Tyr Asp Asn Glu Ala 
                165                 170                 175     


Ile Ala Ile Thr Leu Leu Met Ser Thr Phe Ala Leu Trp Ile Lys Ala 
            180                 185                 190         


Val Lys Ser Gly Ser Ser Phe Trp Gly Ala Cys Thr Gly Leu Leu Tyr 
        195                 200                 205             


Phe Tyr Met Val Thr Ala Trp Gly Gly Tyr Val Phe Ile Thr Asn Met 
    210                 215                 220                 


Ile Pro Leu His Val Phe Val Leu Leu Leu Met Gly Arg Tyr Thr Ser 
225                 230                 235                 240 


Lys Leu Tyr Ile Ala Tyr Thr Thr Tyr Tyr Val Ile Gly Thr Leu Ala 
                245                 250                 255     


Ser Met Gln Val Pro Phe Val Gly Phe Gln Pro Val Ser Thr Ser Glu 
            260                 265                 270         


His Met Ser Ala Leu Gly Val Phe Gly Leu Leu Gln Leu Phe Ala Phe 
        275                 280                 285             


Tyr Asn Tyr Val Lys Gly Leu Val Ser Ser Lys Gln Phe Gln Ile Leu 
    290                 295                 300                 


Ile Arg Phe Ala Leu Val Cys Leu Val Gly Leu Ala Thr Val Val Leu 
305                 310                 315                 320 


Phe Ala Leu Ser Ser Thr Gly Val Ile Ala Pro Trp Thr Gly Arg Phe 
                325                 330                 335     


Tyr Ser Leu Trp Asp Thr Asn Tyr Ala Lys Ile His Ile Pro Ile Ile 
            340                 345                 350         


Ala Ser Val Ser Glu His Gln Pro Pro Thr Trp Ser Ser Leu Phe Phe 
        355                 360                 365             


Asp Leu Gln Phe Leu Ile Trp Leu Leu Pro Val Gly Val Tyr Leu Cys 
    370                 375                 380                 


Phe Lys Glu Leu Arg Asn Glu His Val Phe Ile Ile Ile Tyr Pro Val 
385                 390                 395                 400 


Leu Gly Thr Tyr Phe Cys Gly Val Met Val Arg Leu Val Leu Thr Leu 
                405                 410                 415     


Thr Pro Cys Val Cys Ile Ala Ala Ala Val Ala Ile Ser Thr Leu Leu 
            420                 425                 430         


Asp Thr Tyr Met Gly Pro Glu Val Glu Glu Asp Lys Val Ser Glu Glu 
        435                 440                 445             


Ala Ala Ser Ala Lys Ser Lys Asn Lys Lys Gly Ile Ser Ser Ile Leu 
    450                 455                 460                 


Ser Phe Phe Thr Ser Gly Ser Lys Asn Ile Gly Ile Tyr Ser Leu Leu 
465                 470                 475                 480 


Ser Arg Val Leu Val Ile Ser Ser Thr Ala Tyr Phe Leu Ile Met Phe 
                485                 490                 495     


Val Tyr His Ser Ser Trp Val Thr Ser Asn Ala Tyr Ser Ser Pro Thr 
            500                 505                 510         


Val Val Leu Ser Thr Val Leu Asn Asp Gly Ser Leu Met Tyr Ile Asp 
        515                 520                 525             


Asp Phe Arg Glu Ala Tyr Asp Trp Leu Arg Arg Asn Thr Pro Tyr Asp 
    530                 535                 540                 


Thr Lys Val Met Ser Trp Trp Asp Tyr Gly Tyr Gln Ile Ala Gly Met 
545                 550                 555                 560 


Ala Asp Arg Ile Thr Leu Val Asp Asn Asn Thr Trp Asn Asn Thr His 
                565                 570                 575     


Ile Ala Thr Val Gly Lys Ala Met Ser Ser Pro Glu Glu Lys Ala Tyr 
            580                 585                 590         


Pro Ile Leu Arg Lys His Asp Val Asp Tyr Ile Leu Ile Ile Tyr Gly 
        595                 600                 605             


Gly Thr Leu Gly Tyr Ser Ser Asp Asp Met Asn Lys Phe Leu Trp Met 
    610                 615                 620                 


Ile Arg Ile Ser Gln Gly Leu Trp Pro Asp Glu Ile Val Glu Arg Asn 
625                 630                 635                 640 


Phe Phe Thr Pro Asn Gly Glu Tyr Arg Thr Asp Asp Ala Ala Thr Pro 
                645                 650                 655     


Thr Met Arg Glu Ser Leu Leu Tyr Lys Met Ser Tyr His Gly Ala Trp 
            660                 665                 670         


Lys Leu Phe Pro Pro Asn Gln Gly Tyr Asp Arg Ala Arg Asn Gln Lys 
        675                 680                 685             


Leu Pro Ser Lys Asp Pro Gln Leu Phe Thr Ile Glu Glu Ala Phe Thr 
    690                 695                 700                 


Thr Val His His Leu Val Arg Leu Tyr Lys Val Lys Lys Pro Asp Thr 
705                 710                 715                 720 


Leu Gly Arg Asp Leu Lys Gln Val Thr Leu Phe Glu Glu Gly Lys Arg 
                725                 730                 735     


Lys Lys Ser Ala Val Leu Gln Lys Leu Thr Lys Phe Leu 
            740                 745                 


<210>  29
<211>  2250
<212>  DNA
<213>  Schizosaccharomyces pombe

<400>  29
atggctaatt ctgctacaat tacgagtaaa aaaggcgtga agtctcatca gaaggactgg       60

aaaattccac ttaaagtgct cattcttata tgtattgctg tggcttctgt ctcttcgagg      120

cttttttctg tcattcgtta cgagtccatt attcatgaat ttgatccttg gttcaatttc      180

cgagcttcca aaatattggt ggaacaaggt ttttataact ttttaaattg gtttgatgaa      240

agaagttggt acccgttggg tcgtgtagcg ggtggtactt tgtacccagg acttatggtc      300

acgtctggta ttattttcaa agttttacat cttttaagaa ttaacgtgaa catccgtgat      360

gtatgtgttt tacttgcccc tgctttctct ggaatcactg cgattgctac ctattatctg      420

gctagagaat tgaaaagtga tgcatgtggc cttttagctg ccgcatttat gggtattgct      480

cctggataca cctcccgttc cgtcgctggt tcttacgata atgaagcaat tgctattacc      540

cttttgatgt caacgtttgc tttgtggatc aaggcagtga agtctggctc ctctttctgg      600

ggtgcctgca caggattgct ctacttctat atggtaactg cgtggggtgg ttatgtattc      660

atcacaaaca tgataccttt acacgtattt gttcttctac ttatgggtcg ctatactagc      720

aaattataca ttgcttacac aacatactat gttattggaa cgctggcttc tatgcaagtt      780

ccgtttgttg gtttccaacc cgtgtcgact agtgagcata tgtccgcttt aggagtgttt      840

ggcctgttac agctttttgc attctacaat tatgttaaag gtctagtttc atccaagcaa      900

ttccaaatac ttattcgttt tgccttggtt tgcttagtgg gtctagcaac agtcgtcctt      960

tttgctttat cttcaacagg tgttatcgct ccttggacag gacgtttcta ttctctttgg     1020

gatacaaact acgccaagat tcatattcct atcattgctt cggtatcaga acatcagcct     1080

cctacttgga gttcgttgtt ctttgatctt caatttttga tttggttatt gccagttggt     1140

gtttacttgt gtttcaagga acttcgtaat gaacatgtct ttattattat atatcctgtc     1200

ttaggaacat atttttgtgg tgtgatggtt cgtttggttt taaccttaac tccttgtgtt     1260

tgcatagctg ctgctgtagc aatttccact cttttagaca catatatggg tcctgaagtt     1320

gaagaggaca aagtgagcga agaagccgct tcagccaaat ctaagaacaa gaaaggtatt     1380

tcctctattc ttagtttctt cacttctggc tcaaaaaata ttggaattta cagtttgctt     1440

tccagagtat tagtcatttc ctctaccgca tatttcctaa taatgtttgt ttatcattcc     1500

agttgggtga cttctaatgc ttactcttcc cctaccgtgg ttttgtctac cgtgttaaac     1560

gatggtagtt taatgtatat tgatgacttc cgtgaagctt atgactggct tcgtagaaac     1620

actccttatg acacaaaggt tatgagttgg tgggattatg gttaccaaat tgctggtatg     1680

gctgatcgta ttactttagt cgacaacaat acgtggaaca acacacatat tgccacagtt     1740

ggaaaagcca tgtcttcacc tgaagaaaaa gcttacccta tcctccgtaa acacgatgtt     1800

gattatattc ttattatata tggtggtact cttggataca gcagcgacga catgaacaag     1860

ttcctttgga tgatccgaat ttctcaggga ttatggcccg atgaaatagt agagcgtaac     1920

ttttttactc ctaatggaga atatcgaact gacgatgcgg ctactcccac tatgcgtgag     1980

tctttattat ataagatgtc atatcacggt gcttggaaac ttttccctcc caatcaagga     2040

tatgaccgtg ctcgcaatca aaaactacca tcgaaagatc ctcaactatt tactatcgaa     2100

gaagcattca ctaccgttca tcatttagtt cgtttgtata aggttaagaa accggataca     2160

cttggacgcg atttgaaaca agtgacatta tttgaagaag gcaaaagaaa gaagtccgcc     2220

gtcctgcaaa aactaacgaa attcctttga                                      2250


<210>  30
<211>  714
<212>  PRT
<213>  Dictyostelium discoideum

<400>  30

Met Lys Arg Ser Glu Lys Ser Ser Thr Ser Val Val Ser Asn Asn Lys 
1               5                   10                  15      


Gln Gln Asp Val Asn Ile Ile Ser Ser Asn Glu Val Gly Val Lys Glu 
            20                  25                  30          


Glu Asn Lys Gly His Gln Glu Phe Leu Leu Lys Val Leu Ile Leu Ser 
        35                  40                  45              


Val Ile Tyr Val Leu Ala Phe Ser Thr Arg Leu Phe Ser Val Leu Arg 
    50                  55                  60                  


Tyr Glu Ser Val Ile His Glu Phe Asp Pro Tyr Phe Asn Tyr Arg Ser 
65                  70                  75                  80  


Thr Ile Tyr Leu Val Gln Glu Gly Phe Tyr Asn Phe Leu Asn Trp Phe 
                85                  90                  95      


Asp Glu Arg Ala Trp Tyr Pro Leu Gly Arg Ile Val Gly Gly Thr Ile 
            100                 105                 110         


Tyr Pro Gly Leu Met Ala Thr Ala Ser Leu Val His Trp Ser Leu Asn 
        115                 120                 125             


Ser Leu Asn Ile Thr Val Asn Ile Arg Asn Val Cys Val Leu Leu Ser 
    130                 135                 140                 


Pro Trp Phe Ala Ser Asn Thr Ala Met Val Thr Tyr Lys Phe Ala Lys 
145                 150                 155                 160 


Glu Val Lys Asp Thr Gln Thr Gly Leu Val Ala Ala Ala Met Ile Ala 
                165                 170                 175     


Ile Val Pro Gly Tyr Ile Ser Arg Ser Val Ala Gly Ser Phe Asp Asn 
            180                 185                 190         


Glu Gly Ile Ala Ile Phe Ala Leu Ile Phe Thr Tyr Tyr Cys Trp Ile 
        195                 200                 205             


Lys Ser Val Asn Thr Gly Ser Leu Met Trp Ala Ala Ile Cys Ser Leu 
    210                 215                 220                 


Ala Tyr Phe Tyr Met Ala Ser Ala Trp Gly Gly Tyr Val Phe Ile Ile 
225                 230                 235                 240 


Asn Leu Ile Pro Leu His Ala Phe Phe Leu Leu Leu Thr Gly Arg Tyr 
                245                 250                 255     


Ser His Arg Leu Tyr Ile Ala Tyr Ser Thr Met Phe Val Ile Gly Thr 
            260                 265                 270         


Ile Leu Ser Met Gln Ile Thr Phe Ile Ser Phe Gln Pro Val Gln Ser 
        275                 280                 285             


Ser Glu His Leu Ala Ala Ile Gly Ile Phe Gly Leu Leu Gln Leu Tyr 
    290                 295                 300                 


Ala Gly Leu Ser Trp Val Lys Ser His Leu Thr Asn Glu Ala Phe Lys 
305                 310                 315                 320 


Lys Leu Gln Arg Leu Thr Val Leu Phe Val Leu Ser Cys Ala Ala Ala 
                325                 330                 335     


Val Leu Val Val Gly Thr Leu Thr Gly Tyr Ile Ser Pro Phe Asn Gly 
            340                 345                 350         


Arg Phe Tyr Ser Leu Leu Asp Pro Thr Tyr Ala Arg Asp His Ile Pro 
        355                 360                 365             


Ile Ile Ala Ser Val Ser Glu His Gln Pro Thr Thr Trp Ala Ser Tyr 
    370                 375                 380                 


Phe Phe Asp Leu His Ile Leu Val Phe Leu Phe Pro Ala Gly Leu Tyr 
385                 390                 395                 400 


Phe Cys Phe Gln Lys Leu Thr Asp Ala Asn Ile Phe Leu Ile Leu Tyr 
                405                 410                 415     


Gly Val Thr Ser Ile Tyr Phe Ser Gly Val Met Val Arg Leu Met Leu 
            420                 425                 430         


Val Leu Ala Pro Val Ala Cys Ile Leu Ala Ala Val Ala Val Ser Ala 
        435                 440                 445             


Thr Leu Thr Thr Tyr Met Lys Lys Leu Lys Ala Pro Ser Ser Pro Ser 
    450                 455                 460                 


Asp Ala Asn Asn Ser Lys Glu Ser Gly Gly Val Met Val Ala Val Leu 
465                 470                 475                 480 


Thr Val Leu Leu Ile Leu Tyr Ala Phe His Cys Thr Trp Val Thr Ser 
                485                 490                 495     


Glu Ala Tyr Ser Ser Pro Ser Ile Val Leu Ser Ala Lys Gln Asn Asp 
            500                 505                 510         


Gly Ser Arg Val Ile Phe Asp Asp Phe Arg Glu Ala Tyr Arg Trp Ile 
        515                 520                 525             


Gly Gln Asn Thr Ala Asp Asp Ala Arg Ile Met Ser Trp Trp Asp Tyr 
    530                 535                 540                 


Gly Tyr Gln Leu Ser Ala Met Ala Asn Arg Thr Val Leu Val Asp Asn 
545                 550                 555                 560 


Asn Thr Trp Asn Asn Ser His Ile Ala Gln Val Gly Lys Ala Phe Ala 
                565                 570                 575     


Ser Thr Glu Glu Asp Ala Tyr Ile Gln Met Lys Ala Leu Asp Val Asp 
            580                 585                 590         


Tyr Val Leu Val Ile Phe Gly Gly Leu Thr Gly Tyr Ser Ser Asp Asp 
        595                 600                 605             


Ile Asn Lys Phe Leu Trp Met Val Arg Ile Gly Gly Ser Cys Asp Pro 
    610                 615                 620                 


Asn Ile Lys Glu Gln Asp Tyr Leu Thr Asn Gly Gln Tyr Arg Ile Asp 
625                 630                 635                 640 


Lys Gly Ala Ser Pro Thr Met Leu Asn Ser Leu Met Tyr Lys Leu Ser 
                645                 650                 655     


Tyr Tyr Arg Phe Ser Glu Val His Thr Asp Tyr Gln Arg Pro Thr Gly 
            660                 665                 670         


Phe Asp Arg Val Arg Asn Val Glu Ile Gly Asn Lys Asn Phe Asp Leu 
        675                 680                 685             


Thr Tyr Leu Glu Glu Ala Phe Thr Ser Val His Trp Leu Val Arg Val 
    690                 695                 700                 


Tyr Lys Val Lys Asp Phe Asp Asn Arg Ala 
705                 710                 


<210>  31
<211>  2145
<212>  DNA
<213>  Dictyostelium discoideum

<400>  31
atgaaaagat cagaaaaatc aagtacatct gttgttagta ataacaaaca acaagatgta       60

aatatcatca gttcaaatga agttggtgtt aaagaagaaa ataaaggaca tcaagaattc      120

ttattaaaag ttttaattct atcagtcatt tatgttttag cattttcaac tcgtttattc      180

tcagtattac gttatgaaag tgttattcat gaatttgatc catattttaa ttatagatca      240

acaatatatc ttgttcaaga aggtttttat aattttttaa attggtttga tgaaagagca      300

tggtatccat taggacgtat tgtaggtggt acaatttacc caggtttaat ggcaacagca      360

agtttagttc attggtcatt gaattcattg aatattacag ttaatattag aaatgtatgt      420

gtattgttat caccatggtt tgcatcaaat acagcaatgg taacctataa atttgccaaa      480

gaagttaagg atacacaaac tggtttggtt gcagcagcca tgattgcaat tgttccaggt      540

tatatttcac gttcagtagc aggttcattc gataatgaag gtattgcaat ctttgcattg      600

attttcacat attattgttg gattaagtca gtaaacacag gctcattgat gtgggctgcc      660

atctgttcat tggcctactt ttatatggca agtgcctggg gtggttatgt attcatcatt      720

aatttaatcc cattgcatgc ctttttcttg cttttgacag gccgttattc acatcgtctc      780

tacatagcct acagcacaat gtttgtcatt ggtacaatcc tctctatgca aattacattc      840

attagtttcc aaccagttca atcatctgaa catttggctg ccattggtat ctttggtctc      900

ctccaattgt acgctggttt gtcatgggta aagagtcacc tcaccaatga agccttcaag      960

aaacttcaac gtttgacagt gttattcgtt ttatcttgtg ctgctgccgt acttgtcgtt     1020

ggtacattaa ctggttacat ctcaccattc aatggtcgtt tctattcatt gttggatcca     1080

acctatgctc gtgaccacat tccaatcatt gcatcagtat cagagcatca accaaccact     1140

tgggcatcat actttttcga tctccatatc ttggtattcc ttttcccagc cggtttatac     1200

ttttgtttcc aaaaattaac cgatgctaat attttcctca ttctctacgg tgtcacctcc     1260

atttatttct ctggtgtaat ggtacgtctt atgttggttt tagcaccagt tgcatgtatt     1320

ttagccgccg ttgccgtcag tgcaaccctc accacctata tgaagaagtt aaaggctcca     1380

tcatcaccaa gtgatgctaa taattccaaa gagagtggtg gtgttatggt tgcagtctta     1440

actgttcttt taattctcta cgctttccat tgtacttggg tcactagtga agcctactca     1500

tctccatcca ttgtactctc tgccaaacaa aacgatggta gtcgtgtgat tttcgatgat     1560

ttccgtgaag cctaccgttg gattggtcaa aatactgccg acgacgctcg tattatgtct     1620

tggtgggatt atggttatca attatctgca atggccaatc gtaccgtatt ggttgataat     1680

aacacttgga acaatagtca tatcgctcaa gttggtaaag catttgcatc cactgaagaa     1740

gatgcttaca tacaaatgaa agcattggat gtcgattatg ttttagttat ttttggtggt     1800

ttaactggtt acagttctga tgatatcaat aaattccttt ggatggttag aattggtggt     1860

agttgtgatc caaatattaa agaacaagat tatctcacca atggtcaata tagaatagat     1920

aaaggtgcct caccaacaat gttaaattct ctcatgtaca aacttagtta ctatcgtttc     1980

tctgaagttc acactgacta tcaaagacca acaggtttcg atcgtgtaag aaatgttgaa     2040

attggtaata aaaatttcga tttaacttat ttagaagaag ctttcacatc tgttcattgg     2100

ttagttagag tttataaagt taaagatttt gataatagag cttaa                     2145


<210>  32
<211>  206
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  32

Met Ser Leu Ala Ser Ser Leu Glu Ser Leu Arg Lys Ile Asp Ile Asn 
1               5                   10                  15      


Asp Leu Asp Leu Asn Asn Ile Gly Ser Trp Pro Ala Ala Val Lys Val 
            20                  25                  30          


Ile Val Cys Val Leu Leu Thr Ala Ala Val Leu Ala Leu Gly Tyr Asn 
        35                  40                  45              


Phe His Leu Ser Asp Met Gln Ala Gln Leu Glu Gln Gln Ala Ala Glu 
    50                  55                  60                  


Glu Glu Thr Leu Lys Gln Gln Phe Ser Thr Lys Ala Phe Gln Ala Ala 
65                  70                  75                  80  


Asn Leu Glu Ala Tyr Lys Ala Gln Met Lys Glu Met Glu Glu Ser Phe 
                85                  90                  95      


Gly Ala Leu Leu Arg Gln Leu Pro Ser Asp Thr Glu Val Pro Gly Leu 
            100                 105                 110         


Leu Glu Asp Ile Thr Arg Thr Gly Leu Gly Ser Gly Leu Glu Phe Glu 
        115                 120                 125             


Glu Ile Lys Leu Leu Pro Glu Val Ala Gln Gln Phe Tyr Ile Glu Leu 
    130                 135                 140                 


Pro Ile Gln Ile Ser Val Val Gly Gly Tyr His Asp Leu Ala Thr Val 
145                 150                 155                 160 


Ser Gly Val Ser Ser Leu Pro Arg Ile Val Thr Leu His Asp Phe Glu 
                165                 170                 175     


Ile Lys Pro Val Ala Pro Gly Ser Thr Ser Lys Leu Arg Met Ser Ile 
            180                 185                 190         


Leu Ala Lys Thr Tyr Arg Tyr Asn Asp Lys Gly Leu Lys Lys 
        195                 200                 205     


<210>  33
<211>  624
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  33
atgagtctgg ccagttccct ggaaagtctg cgcaagatcg atatcaacga tctcgacctg       60

aacaacatcg gttcctggcc ggcggcggtc aaggtcatcg tctgcgtgct gctgaccgcg      120

gcggtcctgg cgctgggcta caacttccat ctgagtgaca tgcaggctca gctcgaacag      180

caggccgcgg aagaggagac gctcaagcag cagttctcca ccaaggcctt ccaggccgcg      240

aacctggaag cctacaaggc acagatgaag gagatggaag agtcctttgg cgccttgctg      300

cggcagttgc ccagcgacac cgaggtaccc gggctgctcg aggacatcac tcgtaccggc      360

ctgggcagcg gcctggagtt cgaggaaatc aagctgcttc ccgaggttgc ccagcagttc      420

tacatcgagc tgccgatcca gatcagcgtg gtcggcggct accacgactt ggcgaccttc      480

gtcagcggcg tgtccagcct gccgcggatc gtcaccctgc atgacttcga gatcaagccg      540

gtcgcgcccg gcagcacgtc caagctgcgc atgagcatcc tggccaagac ctatcgctac      600

aacgacaagg ggctgaagaa atga                                             624


<210>  34
<211>  604
<212>  PRT
<213>  Neisseria meningitidis

<400>  34

Met Pro Ala Glu Thr Thr Val Ser Gly Ala His Pro Ala Ala Lys Leu 
1               5                   10                  15      


Pro Ile Tyr Ile Leu Pro Cys Phe Leu Trp Ile Gly Ile Val Pro Phe 
            20                  25                  30          


Thr Phe Ala Leu Lys Leu Lys Pro Ser Pro Asp Phe Tyr His Asp Ala 
        35                  40                  45              


Ala Ala Ala Ala Gly Leu Ile Val Leu Leu Phe Leu Thr Ala Gly Lys 
    50                  55                  60                  


Lys Leu Phe Asp Val Lys Ile Pro Ala Ile Ser Phe Leu Leu Phe Ala 
65                  70                  75                  80  


Met Ala Ala Phe Trp Tyr Leu Gln Ala Arg Leu Met Asn Leu Ile Tyr 
                85                  90                  95      


Pro Gly Met Asn Asp Ile Val Ser Trp Ile Phe Ile Leu Leu Ala Val 
            100                 105                 110         


Ser Ala Trp Ala Cys Arg Ser Leu Val Ala His Phe Gly Gln Glu Arg 
        115                 120                 125             


Ile Val Thr Leu Phe Ala Trp Ser Leu Leu Ile Gly Ser Leu Leu Gln 
    130                 135                 140                 


Ser Cys Ile Val Val Ile Gln Phe Ala Gly Trp Glu Asp Thr Pro Leu 
145                 150                 155                 160 


Phe Gln Asn Ile Ile Val Tyr Ser Gly Gln Gly Val Ile Gly His Ile 
                165                 170                 175     


Gly Gln Arg Asn Asn Leu Gly His Tyr Leu Met Trp Gly Ile Leu Ala 
            180                 185                 190         


Ala Ala Tyr Leu Asn Gly Gln Arg Lys Ile Pro Ala Ala Leu Gly Val 
        195                 200                 205             


Ile Cys Leu Ile Met Gln Thr Ala Val Leu Gly Leu Val Asn Ser Arg 
    210                 215                 220                 


Thr Ile Leu Thr Tyr Ile Ala Ala Ile Ala Leu Ile Leu Pro Phe Trp 
225                 230                 235                 240 


Tyr Phe Arg Ser Asp Lys Ser Asn Arg Arg Thr Met Leu Gly Ile Ala 
                245                 250                 255     


Ala Ala Val Phe Leu Thr Ala Leu Phe Gln Phe Ser Met Asn Thr Ile 
            260                 265                 270         


Leu Glu Thr Phe Thr Gly Ile Arg Tyr Glu Thr Ala Val Glu Arg Val 
        275                 280                 285             


Ala Asn Gly Gly Phe Thr Asp Leu Pro Arg Gln Ile Glu Trp Asn Lys 
    290                 295                 300                 


Ala Leu Ala Ala Phe Gln Ser Ala Pro Ile Phe Gly His Gly Trp Asn 
305                 310                 315                 320 


Ser Phe Ala Gln Gln Thr Phe Leu Ile Asn Ala Glu Gln His Asn Ile 
                325                 330                 335     


Tyr Asp Asn Leu Leu Ser Asn Leu Phe Thr His Ser His Asn Ile Val 
            340                 345                 350         


Leu Gln Leu Leu Ala Glu Met Gly Ile Ser Gly Thr Leu Leu Val Ala 
        355                 360                 365             


Ala Thr Leu Leu Thr Gly Ile Ala Gly Leu Leu Lys Arg Pro Leu Thr 
    370                 375                 380                 


Pro Ala Ser Leu Phe Leu Ile Cys Thr Leu Ala Val Ser Met Cys His 
385                 390                 395                 400 


Ser Met Leu Glu Tyr Pro Leu Trp Tyr Val Tyr Phe Leu Ile Pro Phe 
                405                 410                 415     


Gly Leu Met Leu Phe Leu Ser Pro Ala Glu Ala Ser Asp Gly Ile Ala 
            420                 425                 430         


Phe Lys Lys Ala Ala Asn Leu Gly Ile Leu Thr Ala Ser Ala Ala Ile 
        435                 440                 445             


Phe Ala Gly Leu Leu His Leu Asp Trp Thr Tyr Thr Arg Leu Val Asn 
    450                 455                 460                 


Ala Phe Ser Pro Ala Thr Asp Asp Ser Ala Lys Thr Leu Asn Arg Lys 
465                 470                 475                 480 


Ile Asn Glu Leu Arg Tyr Ile Ser Ala Asn Ser Pro Met Leu Ser Phe 
                485                 490                 495     


Tyr Ala Asp Phe Ser Leu Val Asn Phe Ala Leu Pro Glu Tyr Pro Glu 
            500                 505                 510         


Thr Gln Thr Trp Ala Glu Glu Ala Thr Leu Lys Ser Leu Lys Tyr Arg 
        515                 520                 525             


Pro His Ser Ala Thr Tyr Arg Ile Ala Leu Tyr Leu Met Arg Gln Gly 
    530                 535                 540                 


Lys Val Ala Glu Ala Lys Gln Trp Met Arg Ala Thr Gln Ser Tyr Tyr 
545                 550                 555                 560 


Pro Tyr Leu Met Pro Arg Tyr Ala Asp Glu Ile Arg Lys Leu Pro Val 
                565                 570                 575     


Trp Ala Pro Leu Leu Pro Glu Leu Leu Lys Asp Cys Lys Ala Phe Ala 
            580                 585                 590         


Ala Ala Pro Gly His Pro Glu Ala Lys Pro Cys Lys 
        595                 600                 


<210>  35
<211>  1815
<212>  DNA
<213>  Neisseria meningitidis

<400>  35
atgcccgctg aaacgaccgt atccggcgcg caccccgccg ccaaactgcc gatttacatc       60

ctgccctgct tcctttggat aggcatcgtc ccctttacct tcgcgctcaa actgaaaccg      120

tcgcccgact tttaccacga tgccgccgcc gcagccggcc tgattgtcct gttgttcctc      180

acggcaggaa aaaaactgtt tgatgtcaaa atccccgcca tcagcttcct tctgtttgca      240

atggcggcgt tttggtatct tcaggcacgc ctgatgaacc tgatttaccc cggtatgaac      300

gacatcgtct cttggatttt catcttgctc gccgtcagcg cgtgggcctg ccggagcttg      360

gtcgcacact tcggacaaga acgcatcgtg accctgtttg cctggtcgct gcttatcggc      420

tccctgcttc aatcctgcat cgtcgtcatc cagtttgccg gctgggaaga cacccctctg      480

tttcaaaaca tcatcgttta cagcgggcaa ggcgtaatcg gacacatcgg gcagcgcaac      540

aacctcggac actacctcat gtggggcata ctcgccgccg cctacctcaa cggacaacga      600

aaaatccccg ccgccctcgg cgtaatctgc ctgattatgc agaccgccgt tttaggtttg      660

gtcaactcgc gcaccatctt gacctacata gccgccatcg ccctcatcct tcccttctgg      720

tatttccgtt cggacaaatc caacaggcgg acgatgctcg gcatagccgc agccgtattc      780

cttaccgcgc tgttccaatt ttccatgaac accattctgg aaacctttac tggcatccgc      840

tacgaaactg ccgtcgaacg cgtcgccaac ggcggtttca cagacttgcc gcgccaaatc      900

gaatggaata aagcccttgc cgccttccag tccgccccga tattcgggca cggctggaac      960

agttttgccc aacaaacctt cctcatcaat gccgaacagc acaacatata cgacaacctc     1020

ctcagcaact tgttcaccca ttcccacaac atcgtcctcc aactccttgc agagatggga     1080

atcagcggca cgcttctggt tgccgcaacc ctgctgacgg gcattgccgg gctgcttaaa     1140

cgccccctga cccccgcatc gcttttccta atctgcacgc ttgccgtcag tatgtgccac     1200

agtatgctcg aatatccttt gtggtatgtc tatttcctca tccctttcgg actgatgctc     1260

ttcctgtccc ccgcagaggc ttcagacggc atcgccttca aaaaagccgc caatctcggc     1320

atactgaccg cctccgccgc catattcgca ggattgctgc acttggactg gacatacacc     1380

cggctggtta acgccttttc ccccgccact gacgacagtg ccaaaaccct caaccggaaa     1440

atcaacgagt tgcgctatat ttccgcaaac agtccgatgc tgtcctttta tgccgacttc     1500

tccctcgtaa acttcgccct gccggaatac cccgaaaccc agacttgggc ggaagaagca     1560

accctcaaat cactaaaata ccgcccccac tccgccacct accgcatcgc cctctacctg     1620

atgcggcaag gcaaagttgc agaagcaaaa caatggatgc gggcgacaca gtcctattac     1680

ccctacctga tgccccgata cgccgacgaa atccgcaaac tgcccgtatg ggcgccgctg     1740

ctacccgaac tgctcaaaga ctgcaaagcc ttcgccgccg cgcccggtca tccggaagca     1800

aaaccctgca aatga                                                      1815


