                         SEQUENCE LISTING

<110>  UCB Pharma S.A
 
<120>  Albumin Binding Antibodies and Binding Fragments Thereof

<130>  G0161-WO01

<150>  US61/558,599
<151>  2011-11-11

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of anti-albumin antibody (no ds)

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of anti-albumin antibody (ds)

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of anti-albumin antibody (no ds)

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


<210>  4
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of anti-albumin antibody (ds)

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


<210>  5
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 1

<400>  5

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  6
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker 2

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  7
<211>  357
<212>  PRT
<213>  Artificial

<220>
<223>  A26 Fab Heavy-(G4S,G4T,G4S)-645dsFv(gH5)

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
305                 310                 315                 320 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro 
                325                 330                 335     


Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu 
            340                 345                 350         


Val Thr Val Ser Ser 
        355         


<210>  8
<211>  341
<212>  PRT
<213>  Artificial

<220>
<223>  A26 Fab Light-(3xG4S)-645dsFv(gL4)

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val 
225                 230                 235                 240 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro 
                245                 250                 255     


Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 
            260                 265                 270         


Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val 
        275                 280                 285             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    290                 295                 300                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly 
305                 310                 315                 320 


Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val 
                325                 330                 335     


Glu Ile Lys Arg Thr 
            340     


<210>  9
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  645gH1 heavy chain variable domain

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr 
                85                  90                  95      


Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  645gL1 light chain variable domain

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn 
            20                  25                  30          


Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile 
                85                  90                  95      


Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  11
<211>  355
<212>  PRT
<213>  Artificial

<220>
<223>  A26 Fab Heavy-( 3xG4S)-645dsFv(gH1)

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
225                 230                 235                 240 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                245                 250                 255     


Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr Ala Ile Asn Trp 
            260                 265                 270         


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Ile Ile Trp 
        275                 280                 285             


Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Ser Thr Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
305                 310                 315                 320 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Val Pro Gly Tyr 
                325                 330                 335     


Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
            340                 345                 350         


Val Ser Ser 
        355 


<210>  12
<211>  340
<212>  PRT
<213>  Artificial

<220>
<223>  A26 Fab Light-(3xG4S)-645dsFv(gL1)

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
225                 230                 235                 240 


Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
                245                 250                 255     


Pro Ser Val Trp Ser Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
            260                 265                 270         


Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Thr Ser Gly 
        275                 280                 285             


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    290                 295                 300                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gly 
305                 310                 315                 320 


Gly Gly Tyr Ser Ser Ile Ser Asp Thr Thr Phe Gly Cys Gly Thr Lys 
                325                 330                 335     


Val Glu Ile Lys 
            340 


<210>  13
<211>  789
<212>  DNA
<213>  Artificial

<220>
<223>  645 gH5gL4

<400>  13
gaggttcagc tgctggagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag taagcggcat cgacctgtcc aactacgcga ttaactgggt acgtcaggca      120

ccgggtaaag gtctggaatg gatcggcatc atctgggcct ctggtacgac cttctacgct      180

acttgggcca aaggtcgttt caccatctcc cgtgacaact ctaaaaacac cgtgtacctg      240

cagatgaact ctctgcgtgc ggaagacact gcggtttact attgcgcgcg taccgttccg      300

ggctattcta ctgcaccgta cttcgacctg tggggtcagg gtactctggt taccgtctcg      360

agtggaggtg gcggttctgg cggtggcggt tccggtggcg gtggatcggg aggtggcggt      420

tctgatatcc agatgaccca gagtccaagc agtgtttccg ccagcgtagg cgatcgtgtg      480

actattacct gtcagtcctc tccgagcgtt tggtccaact tcctgagctg gtaccagcag      540

aaaccgggta aagccccgaa actgctgatc tacgaggcgt ctaaactgac ctctggtgta      600

ccgtcccgtt tctctggctc tggctctggt acggacttca ctctgaccat ctcctctctg      660

cagccggaag actttgcaac gtactactgc ggtggtggtt actcttccat ctctgacacc      720

acgttcggtg gaggcaccaa agttgaaatc aaacgtacgc atcaccatca ccatcaccat      780

caccatcac                                                              789


<210>  14
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  645 gH5gL4

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu 
            180                 185                 190         


Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr His His His 
                245                 250                 255     


His His His His His His His 
            260             


<210>  15
<211>  789
<212>  DNA
<213>  Artificial

<220>
<223>  645 gH5gL4ds

<400>  15
gaggttcagc tgctggagtc tggaggcggg cttgtccagc ctggagggag cctgcgtctc       60

tcttgtgcag taagcggcat cgacctgtcc aactacgcga ttaactgggt acgtcaggca      120

ccgggtaaat gcctggaatg gatcggcatc atctgggcct ctggtacgac cttctacgct      180

acttgggcca aaggtcgttt caccatctcc cgtgacaact ctaaaaacac cgtgtacctg      240

cagatgaact ctctgcgtgc ggaagacact gcggtttact attgcgcgcg taccgttccg      300

ggctattcta ctgcaccgta cttcgacctg tggggtcagg gtactctggt taccgtctcg      360

agtggaggtg gcggttctgg cggtggcggt tccggtggcg gtggatcggg aggtggcggt      420

tctgatatcc agatgaccca gagtccaagc agtgtttccg ccagcgtagg cgatcgtgtg      480

actattacct gtcagtcctc tccgagcgtt tggtccaact tcctgagctg gtaccagcag      540

aaaccgggta aagccccgaa actgctgatc tacgaggcgt ctaaactgac ctctggtgta      600

ccgtcccgtt tctctggctc tggctctggt acggacttca ctctgaccat ctcctctctg      660

cagccggaag actttgcaac gtactactgc ggtggtggtt actcttccat ctctgacacc      720

acgttcggtt gtggcaccaa agttgaaatc aaacgtacgc atcaccatca ccatcaccat      780

caccatcac                                                              789


<210>  16
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  645 gH5gL4ds

<400>  16

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Ala Ser Gly Thr Thr Phe Tyr Ala Thr Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Val Pro Gly Tyr Ser Thr Ala Pro Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
    130                 135                 140                 


Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val 
145                 150                 155                 160 


Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Trp Ser Asn Phe Leu Ser 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu 
            180                 185                 190         


Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gly Gly Gly Tyr Ser Ser Ile Ser Asp Thr 
225                 230                 235                 240 


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Arg Thr His His His 
                245                 250                 255     


His His His His His His His 
            260             


<210>  17
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  17

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  18
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  18

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  19
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  cKappa

<400>  19

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
1               5                   10                  15      


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            20                  25                  30          


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        35                  40                  45              


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
65                  70                  75                  80  


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                85                  90                  95      


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105 


<210>  20
<211>  103
<212>  PRT
<213>  Artificial

<220>
<223>  CH1

<400>  20

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys 
            100             


<210>  21
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  21

Ser Gly Gly Gly Gly Ser Glu 
1               5           


<210>  22
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  22

Asp Lys Thr His Thr Ser 
1               5       


<210>  23
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  23

Gly Gly Gly Gly Ser 
1               5   


<210>  24
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  24

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  26
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  26

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  27
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  27

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  28
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  28

Ala Ala Ala Gly Ser Gly Gly Ala Ser Ala Ser 
1               5                   10      


<210>  29
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
1               5                   10                  15      


<210>  30
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ala Ser Ala Ser 
            20      


<210>  31
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25      


<210>  32
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25                  30      


<210>  33
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Ala Ala Ala Gly Ser Gly Xaa Ser Gly Ala Ser Ala Ser 
1               5                   10              


<210>  34
<211>  56
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  34

Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr Arg Arg Pro Ala Thr Thr 
1               5                   10                  15      


Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser His Tyr Pro Gly Gly Asn 
            20                  25                  30          


Arg Gly Thr Thr Thr Thr Arg Arg Pro Ala Thr Thr Thr Gly Ser Ser 
        35                  40                  45              


Pro Gly Pro Thr Gln Ser His Tyr 
    50                  55      


<210>  35
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  35

Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr 
1               5                   10      


<210>  36
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  36

Ala Thr Thr Thr Gly Ser 
1               5       


<210>  37
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  37

Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Ser Pro Pro Ser Lys Glu 
1               5                   10                  15      


Ser His Lys Ser Pro 
            20      


<210>  38
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  38

Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  39

Gly Gly Gly Gly Ile Ala Pro Ser Met Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  40

Gly Gly Gly Gly Lys Val Glu Gly Ala Gly Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  41

Gly Gly Gly Gly Ser Met Lys Ser His Asp Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  42

Gly Gly Gly Gly Asn Leu Ile Thr Ile Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  43

Gly Gly Gly Gly Val Val Pro Ser Leu Pro Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  44
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  44

Gly Gly Glu Lys Ser Ile Pro Gly Gly Gly Gly Ser 
1               5                   10          


<210>  45
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  45

Arg Pro Leu Ser Tyr Arg Pro Pro Phe Pro Phe Gly Phe Pro Ser Val 
1               5                   10                  15      


Arg Pro 
        


<210>  46
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  46

Tyr Pro Arg Ser Ile Tyr Ile Arg Arg Arg His Pro Ser Pro Ser Leu 
1               5                   10                  15      


Thr Thr 
        


<210>  47
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  47

Thr Pro Ser His Leu Ser His Ile Leu Pro Ser Phe Gly Leu Pro Thr 
1               5                   10                  15      


Phe Asn 
        


<210>  48
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  48

Arg Pro Val Ser Pro Phe Thr Phe Pro Arg Leu Ser Asn Ser Trp Leu 
1               5                   10                  15      


Pro Ala 
        


<210>  49
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  49

Ser Pro Ala Ala His Phe Pro Arg Ser Ile Pro Arg Pro Gly Pro Ile 
1               5                   10                  15      


Arg Thr 
        


<210>  50
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  50

Ala Pro Gly Pro Ser Ala Pro Ser His Arg Ser Leu Pro Ser Arg Ala 
1               5                   10                  15      


Phe Gly 
        


<210>  51
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  51

Pro Arg Asn Ser Ile His Phe Leu His Pro Leu Leu Val Ala Pro Leu 
1               5                   10                  15      


Gly Ala 
        


<210>  52
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  52

Met Pro Ser Leu Ser Gly Val Leu Gln Val Arg Tyr Leu Ser Pro Pro 
1               5                   10                  15      


Asp Leu 
        


<210>  53
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  53

Ser Pro Gln Tyr Pro Ser Pro Leu Thr Leu Thr Leu Pro Pro His Pro 
1               5                   10                  15      


Ser Leu 
        


<210>  54
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  54

Asn Pro Ser Leu Asn Pro Pro Ser Tyr Leu His Arg Ala Pro Ser Arg 
1               5                   10                  15      


Ile Ser 
        


<210>  55
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  55

Leu Pro Trp Arg Thr Ser Leu Leu Pro Ser Leu Pro Leu Arg Arg Arg 
1               5                   10                  15      


Pro 
    


<210>  56
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  56

Pro Pro Leu Phe Ala Lys Gly Pro Val Gly Leu Leu Ser Arg Ser Phe 
1               5                   10                  15      


Pro Pro 
        


<210>  57
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  57

Val Pro Pro Ala Pro Val Val Ser Leu Arg Ser Ala His Ala Arg Pro 
1               5                   10                  15      


Pro Tyr 
        


<210>  58
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  58

Leu Arg Pro Thr Pro Pro Arg Val Arg Ser Tyr Thr Cys Cys Pro Thr 
1               5                   10                  15      


Pro 
    


<210>  59
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  59

Pro Asn Val Ala His Val Leu Pro Leu Leu Thr Val Pro Trp Asp Asn 
1               5                   10                  15      


Leu Arg 
        


<210>  60
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  60

Cys Asn Pro Leu Leu Pro Leu Cys Ala Arg Ser Pro Ala Val Arg Thr 
1               5                   10                  15      


Phe Pro 
        


<210>  61
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  61

Gly Ala Pro Ala Pro Ala Ala Pro Ala Pro Ala 
1               5                   10      


<210>  62
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  62

Pro Pro Pro Pro 
1               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  63

Asp Lys Thr His Thr Cys Ala Ala 
1               5               


<210>  64
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  64

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10      


<210>  65
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  65

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  66
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  66

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  67
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  67

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  68
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  68

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  69
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  69

Asp Lys Thr His Thr Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  70
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  70

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  71
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  71

Asp Lys Thr His Thr Cys Pro Ser Cys Pro Ala 
1               5                   10      


