                         SEQUENCE LISTING

<110>  NATIONWIDE CHILDREN'S HOSPITAL, INC.
 
<120>  RECOMBINANT ADENO-ASSOCIATED VIRUS DELIVERY OF ALPHA SARCOGLYCAN 
       POLYNUCLEOTIDES

<130>  28335/45210PCT

<150>  US-61/563,139
<151>  2011-11-23

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  2217
<212>  DNA
<213>  Adeno-Associated Virus rh.74

<400>  1
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc       60

gagtggtggg acctgaaacc tggagccccg aaacccaaag ccaaccagca aaagcaggac      120

aacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac      180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac      240

cagcagctcc aagcgggtga caatccgtac ctgcggtata atcacgccga cgccgagttt      300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgcgc agtcttccag      360

gccaaaaagc gggttctcga acctctgggc ctggttgaat cgccggttaa gacggctcct      420

ggaaagaaga gaccggtaga gccatcaccc cagcgctctc cagactcctc tacgggcatc      480

ggcaagaaag gccagcagcc cgcaaaaaag agactcaatt ttgggcagac tggcgactca      540

gagtcagtcc ccgaccctca accaatcgga gaaccaccag caggcccctc tggtctggga      600

tctggtacaa tggctgcagg cggtggcgct ccaatggcag acaataacga aggcgccgac      660

ggagtgggta gttcctcagg aaattggcat tgcgattcca catggctggg cgacagagtc      720

atcaccacca gcacccgcac ctgggccctg cccacctaca acaaccacct ctacaagcaa      780

atctccaacg ggacctcggg aggaagcacc aacgacaaca cctacttcgg ctacagcacc      840

ccctgggggt attttgactt caacagattc cactgccact tttcaccacg tgactggcag      900

cgactcatca acaacaactg gggattccgg cccaagaggc tcaacttcaa gctcttcaac      960

atccaagtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taaccttacc     1020

agcacgattc aggtctttac ggactcggaa taccagctcc cgtacgtgct cggctcggcg     1080

caccagggct gcctgcctcc gttcccggcg gacgtcttca tgattcctca gtacgggtac     1140

ctgactctga acaatggcag tcaggctgtg ggccggtcgt ccttctactg cctggagtac     1200

tttccttctc aaatgctgag aacgggcaac aactttgaat tcagctacaa cttcgaggac     1260

gtgcccttcc acagcagcta cgcgcacagc cagagcctgg accggctgat gaaccctctc     1320

atcgaccagt acttgtacta cctgtcccgg actcaaagca cgggcggtac tgcaggaact     1380

cagcagttgc tattttctca ggccgggcct aacaacatgt cggctcaggc caagaactgg     1440

ctacccggtc cctgctaccg gcagcaacgc gtctccacga cactgtcgca gaacaacaac     1500

agcaactttg cctggacggg tgccaccaag tatcatctga atggcagaga ctctctggtg     1560

aatcctggcg ttgccatggc tacccacaag gacgacgaag agcgattttt tccatccagc     1620

ggagtcttaa tgtttgggaa acagggagct ggaaaagaca acgtggacta tagcagcgtg     1680

atgctaacca gcgaggaaga aataaagacc accaacccag tggccacaga acagtacggc     1740

gtggtggccg ataacctgca acagcaaaac gccgctccta ttgtaggggc cgtcaatagt     1800

caaggagcct tacctggcat ggtgtggcag aaccgggacg tgtacctgca gggtcccatc     1860

tgggccaaga ttcctcatac ggacggcaac tttcatccct cgccgctgat gggaggcttt     1920

ggactgaagc atccgcctcc tcagatcctg attaaaaaca cacctgttcc cgcggatcct     1980

ccgaccacct tcaatcaggc caagctggct tctttcatca cgcagtacag taccggccag     2040

gtcagcgtgg agatcgagtg ggagctgcag aaggagaaca gcaaacgctg gaacccagag     2100

attcagtaca cttccaacta ctacaaatct acaaatgtgg actttgctgt caatactgag     2160

ggtacttatt ccgagcctcg ccccattggc acccgttacc tcacccgtaa tctgtaa        2217


<210>  2
<211>  738
<212>  PRT
<213>  Adeno-Associated Virus rh.74

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  3
<211>  1164
<212>  DNA
<213>  Homo sapiens

<400>  3
atggccgaga cactgttctg gactcctctg ctggtggtgc tgctggctgg actgggagat       60

accgaggctc agcagaccac actgcaccca ctggtgggcc gggtgttcgt gcacaccctg      120

gaccatgaga catttctgag tctgccagaa cacgtggctg tgccacctgc tgtgcatatc      180

acttaccacg cccatctgca gggccatcct gatctgccac ggtggctgag atacacccag      240

agatcacccc accatcctgg attcctgtat ggaagcgcta ccccagagga caggggactg      300

caggtgatcg aagtgacagc ttacaaccgc gacagttttg atactaccag gcagcgcctg      360

gtgctggaga ttggggatcc agaaggaccc ctgctgcctt atcaggccga gttcctggtg      420

cggtcacacg acgctgagga agtgctgcca tcaacacccg ccagcagatt tctgtccgct      480

ctgggaggac tgtgggagcc aggagaactg cagctgctga atgtgactag cgctctggat      540

aggggaggaa gggtgccact gccaatcgag ggaaggaagg aaggggtgta cattaaagtg      600

ggaagcgctt ccccattctc cacctgcctg aagatggtgg cttctcctga tagtcacgct      660

aggtgcgctc agggacagcc accactgctg tcctgttatg acacactggc cccccatttt      720

cgcgtggact ggtgcaacgt gactctggtg gataaatctg tgcctgagcc agctgacgaa      780

gtgccaaccc ctggagacgg aatcctggag cacgatcctt tcttttgtcc tccaacagaa      840

gccccagaca gggatttcct ggtggacgct ctggtgactc tgctggtgcc tctgctggtg      900

gctctgctgc tgaccctgct gctggcttat gtgatgtgct gtcggagaga gggacggctg      960

aagagagacc tggccacatc tgatatccag atggtgcacc attgtactat tcacggcaac     1020

accgaggaac tgcgccagat ggctgcttct agggaggtgc caaggccact gagtacactg     1080

cctatgttta atgtgcacac tggcgaacgg ctgcccccta gagtggatag cgcccaggtg     1140

ccactgattc tggaccagca ttga                                            1164


<210>  4
<211>  738
<212>  PRT
<213>  Adeno-Associated Virus 8

<400>  4

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  5
<211>  4472
<212>  DNA
<213>  Adeno-Associated Virus rh.74

<400>  5
ctccatcact aggggtaacc gcgaagcgcc tcccacgctg ccgcgtcagc gctgacgtaa       60

attacgtcat aggggagtgg tcctgtatta gctgtcacgt gagtgctttt gcgacatttt      120

gcgacaccac gtggccattc atggtatata tggccgagtg agcgagcagg atctccattt      180

tgaccgcgaa atttgaacga gcagcagcca tgccgggctt ctacgagatc gtgcttaagg      240

tgccgagcga cctggacgag cacctgccgg gcatttctga ctcgtttgtg aactgggtgg      300

cagagaagga atgggagctg cccccggatt ctgacatgga tcggaatctg attgagcagg      360

cacccctgac cgtggccgag aagctacagc gcgacttcct ggtccaatgg cgccgcgtga      420

gtaaggcccc ggaggccctc ttctttgttc agttcgagaa gggcgagtcc tacttccacc      480

tccatattct ggtagagacc acgggggtca aatccatggt gctgggccgc ttcctgagtc      540

agattcggga caagctggtg cagaccatct accgcgggat cgagccgacc ctgcccaact      600

ggttcgcggt gacaaagacg cgtaatggcg ccggaggggg gaacaaggtg gtggacgagt      660

gctacatccc caactacctg ctgcccaaga ctcagcccga gctgcagtgg gcgtggacta      720

acatggagga gtatataagc gcgtgcttga acctggccga gcgcaaacgg ctcgtggcgc      780

agcacctgac ccacgtcagc cagacccagg agcagaacaa ggagaatctg aacccgaatt      840

ctgacgcgcc tgtcatccgg tcaaaaacct ccgcgcgcta catggagctg gtcgggtggc      900

tggtggaccg gggcatcacc tccgagaagc agtggatcca ggaggaccag gcctcgtaca      960

tctccttcaa cgccgcctcc aactcgcggt ctcagatcaa ggccgcgctg gacaatgccg     1020

gcaagatcat ggcgctgacc aaatccgcgc ccgactacct ggtaggcccc gctctgcccg     1080

cggacattaa atccaaccgc atctaccgca tcctggagct gaatggctac gaccctgcct     1140

acgccggttc cgtctttctc ggctgggccc agaaaaagtt tggcaaaagg aacaccatct     1200

ggctgtttgg gccggccacc acgggcaaga ccaacatcgc ggaagccatc gcccacgccg     1260

tgcccttcta cggctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg     1320

acaagatggt gatctggtgg gaggagggca agatgacggc caaggtcgtg gagtccgcca     1380

aggccattct cggcggcagc aaggtgcgcg tggaccaaaa gtgcaagtcg tccgcccaga     1440

tcgatcccac ccccgtgatc gtcacctcca acaccaacat gtgcgccgtg attgacggga     1500

acagcaccac cttcgagcac cagcagccgt tgcaggaccg gatgttcaaa tttgaactta     1560

cccgccgtct ggagcacgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc     1620

gctgggcgca ggatcacgtg accgaggtgg cgcatgagtt ctacgtcaga aagggtggag     1680

ctaacaaaag acccgccccc gatgacgcgg atataagcga gcccaagcgg gcctgcccct     1740

cagtcgcgga tccatcgacg tcagacgcgg aaggagctcc ggtggacttt gccgacaggt     1800

accaaaacaa atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaaaacat     1860

gcgagagaat gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag     1920

aatgtttccc tggcgtgtca gaatctcaac cggtcgtcag aaaaaagacg tatcggaaac     1980

tctgtgcgat tcatcatctg ctggggcggg cacccgagat tgcttgctcg gcctgcgacc     2040

tggtcaacgt ggacctggat gactgtgttt ctgagcaata aatgacttaa accaggtatg     2100

gctgccgatg gttatcttcc agattggctc gaggacaacc tctctgaggg cattcgcgag     2160

tggtgggacc tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacaac     2220

ggccggggtc tggtgcttcc tggctacaag tacctcggac ccttcaacgg actcgacaag     2280

ggggagcccg tcaacgcggc ggacgcagcg gccctcgagc acgacaaggc ctacgaccag     2340

cagctccaag cgggtgacaa tccgtacctg cggtataatc acgccgacgc cgagtttcag     2400

gagcgtctgc aagaagatac gtcttttggg ggcaacctcg ggcgcgcagt cttccaggcc     2460

aaaaagcggg ttctcgaacc tctgggcctg gttgaatcgc cggttaagac ggctcctgga     2520

aagaagagac cggtagagcc atcaccccag cgctctccag actcctctac gggcatcggc     2580

aagaaaggcc agcagcccgc aaaaaagaga ctcaattttg ggcagactgg cgactcagag     2640

tcagtccccg accctcaacc aatcggagaa ccaccagcag gcccctctgg tctgggatct     2700

ggtacaatgg ctgcaggcgg tggcgctcca atggcagaca ataacgaagg cgccgacgga     2760

gtgggtagtt cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc     2820

accaccagca cccgcacctg ggccctgccc acctacaaca accacctcta caagcaaatc     2880

tccaacggga cctcgggagg aagcaccaac gacaacacct acttcggcta cagcaccccc     2940

tgggggtatt ttgacttcaa cagattccac tgccactttt caccacgtga ctggcagcga     3000

ctcatcaaca acaactgggg attccggccc aagaggctca acttcaagct cttcaacatc     3060

caagtcaagg aggtcacgca gaatgaaggc accaagacca tcgccaataa ccttaccagc     3120

acgattcagg tctttacgga ctcggaatac cagctcccgt acgtgctcgg ctcggcgcac     3180

cagggctgcc tgcctccgtt cccggcggac gtcttcatga ttcctcagta cgggtacctg     3240

actctgaaca atggcagtca ggctgtgggc cggtcgtcct tctactgcct ggagtacttt     3300

ccttctcaaa tgctgagaac gggcaacaac tttgaattca gctacaactt cgaggacgtg     3360

cccttccaca gcagctacgc gcacagccag agcctggacc ggctgatgaa ccctctcatc     3420

gaccagtact tgtactacct gtcccggact caaagcacgg gcggtactgc aggaactcag     3480

cagttgctat tttctcaggc cgggcctaac aacatgtcgg ctcaggccaa gaactggcta     3540

cccggtccct gctaccggca gcaacgcgtc tccacgacac tgtcgcagaa caacaacagc     3600

aactttgcct ggacgggtgc caccaagtat catctgaatg gcagagactc tctggtgaat     3660

cctggcgttg ccatggctac ccacaaggac gacgaagagc gattttttcc atccagcgga     3720

gtcttaatgt ttgggaaaca gggagctgga aaagacaacg tggactatag cagcgtgatg     3780

ctaaccagcg aggaagaaat aaagaccacc aacccagtgg ccacagaaca gtacggcgtg     3840

gtggccgata acctgcaaca gcaaaacgcc gctcctattg taggggccgt caatagtcaa     3900

ggagccttac ctggcatggt gtggcagaac cgggacgtgt acctgcaggg tcccatctgg     3960

gccaagattc ctcatacgga cggcaacttt catccctcgc cgctgatggg aggctttgga     4020

ctgaagcatc cgcctcctca gatcctgatt aaaaacacac ctgttcccgc ggatcctccg     4080

accaccttca atcaggccaa gctggcttct ttcatcacgc agtacagtac cggccaggtc     4140

agcgtggaga tcgagtggga gctgcagaag gagaacagca aacgctggaa cccagagatt     4200

cagtacactt ccaactacta caaatctaca aatgtggact ttgctgtcaa tactgagggt     4260

acttattccg agcctcgccc cattggcacc cgttacctca cccgtaatct gtaattacat     4320

gttaatcaat aaaccggtta attcgtttca gttgaacttt ggtctcctgt ccttcttatc     4380

ttatcggtta ccatagaaac tggttactta ttaactgctt ggtgcgcttc gcgataaaag     4440

acttacgtca tcgggttacc cctagtgatg ga                                   4472


