                         SEQUENCE LISTING

<110>  Kymab Limited
 
<120>  TRANSGENIC ANIMALS

<130>  25077.20

 
<150> USSN 13/310,431
<151> 2/12/2011

<150> GB1122047.2
<151> 21/12/2011

<150> 13/416,684
<151> 09/03/2012

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  2256
<212>  DNA
<213>  Rattus norvegicus

<400>  1
atgttatctc tgacctgggg tatgaagcta gtggaaagat ctgtggtccc cagggtcctc       60

ctcttgctct ttgcactctg gctgctcctc ctggttccag tccggtgttc tgaaggccac      120

cccacttggc gctacatctc atcagaggtg gttattcctc ggaaggagat ctaccacagc      180

aaaggaattc aaacacaagg acggctctcc tatagcttgc gttttagggg ccagagacat      240

atcatccacc tgcgaagaaa gacactaatt tggcccagac acttgttgct gacaactcag      300

gatgaccaag gagccttaca gatggattac ccttttttcc ctgtagattg ttactatttt      360

ggctacctag agggaatccc tcaatccatg gtcactgtga atacttgcta tggaggcctg      420

gaagggatca tgatgttgga tgaccttgcc tatgaaatca aacccctcaa cgattcacag      480

gggtttgaac acattgtttc tcagatagta tcagagcctg atgtaacagg gcctacaaat      540

acatggaaac gcttgaacct taatacaggt cctcccttat ccaggacaga gtatgccaat      600

ggaactccca gaatgtctag taagaactac gcttcacatc cagctgctat aaaaggccaa      660

ttccaagcaa ctaattctat atataaggaa agcaacaata ttgatactgc ggccaggtat      720

ttgtttgagc tccttagtat aacggacagc tttctgatca ctattcatat gcggtactat      780

gctattctct taactgtgtt taccgagagc gatccatttg cactagagta tacggtacca      840

gggggctcta tttataacta ttatgtgtct aactttttta atcggttgag gcctgatgca      900

tcaaccgtac ttaataaaga tgggccctcg gataacgact ttcatccagt tgaacagagt      960

ttatgtactc ccgcaggcct gacgattgtt ggtcaacaca gacgaagttt tctagctcta     1020

tctgttatga tcaccaatcg tattgcgatg tctttaggta taaaagctga tgatgagact     1080

tactgcatct gccacagaag gaccacttgc attatgtaca aaaaccctga aataacagat     1140

gctttcagca attgctccct tgtgcagata aaccagatac tgaatacccc tggtacaatg     1200

tcatgccttt tctatgacca ccatgtttat cataatataa caaaaaccta caggttttgt     1260

ggaaacttca agatagatat cggtgagcag tgtgactgtg gctcacataa ggcatgttac     1320

gcagatccct gctgcggaag taattgcaag ttaactgctg gtagcatttg tgataaagaa     1380

ttatgctgtg caaactgcac ctacagtcct tctgggacac tctgcagacc gatccagaac     1440

atatgtgatc ttccagaata ctgtagtggg aataatatct tttgccctgc agacacttat     1500

ctgcaagatg ggacgccatg ctcagaagag gggtactgct ataaaggcaa ctgcacagat     1560

cgcagtgtgc agtgcaagga aatctttggt atgaatgcta agggtgctaa tatcaagtgc     1620

tatgacatca acaaacaacg gtttcgattt gggcactgca ctagagcaca agagagcctc     1680

atgtttaatg cttgctctga tcatgataaa ctgtgtggaa ggctgcagtg taccaacgtc     1740

accaatcttc cattcctgca ggaacatgtt tcattccatc aatcggttat ctctgggttt     1800

acctgctttg ggcttgatga acatcgtggg acagaaacaa cggatgctgg gctggtgaaa     1860

catggtaccc cttgctccca aactaacttc tgcgatcgag gagcttgcaa tggaagttta     1920

tctcggttgg attatgactg caccccagaa aaatgcaatt ttagaggagt gtgtaataat     1980

catcggcatt gccattgtca tttaggttgg aaacctcctc tgtgcagaga ggaggggcct     2040

agcgggagca cggacagtgg gtcccctccg aaggaaaggc gcacaataaa acagagcaga     2100

gaaccactgt tatatttaag aatgctcttt ggtcgtcttt atttattcat tgtctcgctg     2160

ctctttggag tggccactcg cgcaggagtt attaaggtct ttaagtttga agacttgcaa     2220

gctgctctgc gggctgcaca agccaaggcg acttaa                               2256


<210>  2
<211>  2196
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  2
atggtgctgg cagaaggaca ggtcacgctg ctcctgcttg ggctctgggt gctcctagac       60

ccaggtcagt gttccccagg ccgcccctcc tggcgctatg tctcatctga ggtggtgatt      120

cctcggaagg agctgcacca gggcagaggt gttcaggtag caggctggct ctccatcagc      180

ctgcactttg ggggccaaag acacgtcatc tgtatgcgga gcaagaagct tatttgggcc      240

agacacctga tgatgatgac ccaagatgac caaggagcgt tgcagatgga ctatccttac      300

attcctacag actgttacta cctcggccac ctggaagaca ttcctctgtc caccgtcacc      360

attgacacgt gctatggggg cctggaaggc atcatgaagt tggatgacct cgcctatgaa      420

atcaaacccc tcaaggactc caacacattt gaacacgttg tgtctcagat cgtggccgac      480

cgcaatgcca cgggacccat gtacagactg gaacacgagg acgattttga ccccttcttc      540

tccgaggtaa acagtagtgt ggctcccaag ctctctagtt tcaaccacat gtaccacatg      600

gcccaattga aaggtcaaat tcaaatagcc cacgaaatgt atacggtact caacaatatt      660

tcaaaatgca tccaattttc aataaacatg tttagtatta ttgacagttt tctgagagga      720

attggcttta ggcactatat tgctctccta aacatataca accagcaaga gccagtcgtt      780

atgaatgatt ttcgggttcc tggcggtcca atccatgctt attataaagc gaattttcat      840

gacatctacc gcccttctcc atcgacattg attacaagaa atgcaccaaa tgatgattac      900

caagaacccg ctaggtatgg cacctgtggc catcataact tgcttatcat tggttcccag      960

ggcagacatt atctcctgtt ggctatttta actacacata aaattgcacg acagataggg     1020

ttagcatatg actacagtgt ctgtgtgtgc cagagaagag caacctgctt gatgaggaaa     1080

ttccctgaaa tgacagactc gttcagtaac tgctcttttg tccatacaca acatatagtt     1140

tcaaacagat atatttttac atgctattac ttcacagata ggacgtacat gaataaaacc     1200

ctgatacaga cgcgctgtgg aaacttttta gtggaagaaa gggagcaatg tgattgtggc     1260

tccttcaagc attgttatgc caatgcatgc tgtcaaagcg actgtcgctt cacacctgga     1320

agtatttgtg ataaacaaca atgctgcaca aactgcacct actcccccac ttcaaccctc     1380

tgcagacctg tcatgaacat atgtgatctt ccagagtact gtggggggtc cacctacaca     1440

tgccctgaaa atttttattt gcaagacgga accccgtgca ctgaagatgg ttactgctac     1500

agagggaact gctctgaccc cactatgcac tgcaaggaga tctttggtca aagtgctgag     1560

aatggtcctg cggattgcta tgccataaat ctcaacacct tccgatttgg acattgtaga     1620

agagagcaac atcagaacgt ttaccatgct tgtgctgcac aagacaagga gtgtggaagg     1680

ctacagtgca tcaatgtcac ccagcttcct cagttgcagg atcatgtttc attccatcag     1740

tctgtgtaca atgagttcac ctgttttgga ctggatgaac accggtcaac aggatcaact     1800

gatgctggac gtgtgagaga tggtactccc tgtggggaag gacttttctg tcttgagagc     1860

agatgcaaca tgactatgct taacctgcat tacgactgtt tccctgagaa gtgcagtttt     1920

agaggacttt gcaacaataa caagaattgc cactgccatg ttggctggga ccccccactg     1980

tgcctgagtc cgggtgctgg tgggagctca caaagcgggc cccctccaag gagaatgcgc     2040

acagtcacag atagcatgga gccaattctt tatttaagag tggtctttgc tcgtgtttat     2100

tgttttattt ttgcactgct ctttggggta gccactaatg tgcgaacgat taagactacc     2160

attgtccagg aacaaacagt taatgagcca cagtaa                               2196


<210>  3
<211>  2265
<212>  DNA
<213>  Mus musculus

<400>  3
atgttatctc tgacctgggg catgaggcta gtggaaagac ctgtggtccc cagggtcctc       60

ctcttgctat ttgcactctg gctgctcctc ctggttccag tctggtgttc tcaaggccat      120

cccacttggc gttacatctc atcggaggtg gttattcctc ggaaggagat ctaccatacc      180

aaaggacttc aagcacaaag actgctctcg tatagcttgc gttttcgggg ccagagacat      240

atcatccacc tgcggagaaa gacactcatt tggcccagac acttgttgct gacaactcaa      300

gatgaccaag gagccttaca gatggagtac cccttttttc ctgtagattg ttactatatt      360

ggctacctgg aggggatcct gcaatccatg gtcactgtgg atacttgtta tgggggcctg      420

tcaggggtca taaagttgga taaccttacc tatgaaatca aacccctcaa tgattcacag      480

agctttgaac accttgtttc tcagatagta tctgagtctg atgacacagg gcctatgaat      540

gcatggaagc actggagcca taatacaggt tctccctcct ccagattgga atatgcagat      600

ggagctccca gactatctag taagaattac gctacacatc cagctgctat aaaaggccac      660

tttcaagcaa cccattctgt atatagtgct tctggaggtg acaaactttc atctactgtt      720

gagtatttgt ttaaagtcat tagtttaatg gacacctatc tgaccaatct tcatatgcgg      780

tactatgtct ttctcatgac tgtgtatacc gaggctgatc cattttcaca agattttcga      840

gttccaggag ggcaggctca tactttctat gagagagtat tttatgctca ttttaggcct      900

gatgcaggag ctataattaa caagaattcg ccaggagatg atgctgttaa tccagctgag      960

aggagtatat gttctccctc agccctaatt tgtcttggtc aacatggtcg aaatccttta     1020

tttttatcta ttataataac caatcgtgtt ggaaggagtt taggcctaaa acatgatgag     1080

gggtactgta tctgccagag aaggaacacc tgcatcatgt tcaaaaatcc tcaattaaca     1140

gatgctttca gcaattgttc ccttgcagag ataagcaaca tacttaatac tcctgatctg     1200

atgccatgtc ttttctatga ccgtcatgtt tattataata catcattgac ttataagttt     1260

tgtggaaact tcaaagtaga taacaatgag cagtgtgact gtggctccca aaaggcatgt     1320

tattcagatc cctgctgtgg aaatgattgc aggttaacac ctggtagcat ttgtgataaa     1380

gaattatgct gtgcaaattg cacttacagt ccttctggga cactctgcag acctatccag     1440

aacatatgtg atcttccaga gtactgtagt ggctctaagt tcatttgccc agatgacact     1500

tatctgcaag atgggacacc atgctcagaa gagggttact gctataaagg taactgcact     1560

gatcgcaaca tacaatgcat ggaaatcttt ggtgtaagtg ctaagaatgc taatattaag     1620

tgctatgaca tcaacaaaca acggtttcga tttgggcatt gtactagagc agaagaaagc     1680

ctcacattca atgcttgtgc tgatcaggac aagctgtgtg gaaggttgca gtgtaccaat     1740

gtcaccaatc ttccattttt gcaagaacat gtttcattcc atcaatcggt tatctctggg     1800

gttacctgct ttgggcttga tgaacatcgt gggacagaaa cagcagatgc tggattggtg     1860

agacatggta ccccgtgttc aaggggtaag ttctgtgatc gaggagcttg caatggaagt     1920

ttatctcgtt tgggttatga ctgcacccca gaaaaatgca atttcagagg agtgtgtaac     1980

aatcgtcgga attgccattg ccattttggt tggagccctc caaagtgcaa agaagaggga     2040

cacagtggga gcatagacag tgggtcccct ccggttcaaa ggcgcataat aaaacagaac     2100

ctagagccag tagtgtattt aagaatactc tttggtcgta tttacttcct ctttgttgca     2160

ctgctctttg gcattgccac tcgtgtagga gttactaaga tatttaggtt tgaagacttg     2220

caagctgctt tacgttcttg gcaagaacaa gcaaaggaca agtaa                     2265


<210>  4
<211>  2271
<212>  DNA
<213>  Mus musculus

<400>  4
atgttatctc tgacctgggg catgaggcta gtggaaagac ctgtggtccc cagggtcctc       60

ctcttgctat ttgcactctg gctgctcctc ctggttccag tctggtgttc tcaaggccat      120

cctacttggc gttacatctc atcggaggtg gttattcctc ggaaggagat ctaccatacc      180

aaaggacttc aagcacaaag actgctctca tatagcttgc attttcgggg ccagagacat      240

atcatccacc tgcggagaaa gacactcatt tggcccagac acttgttgct gacaactcaa      300

gatgaccaag gagccttaca gatggattac cccttttttc ctgtagattg ttactatatt      360

ggctacctgg aggggatccc acaatccatg gtcactgtgg atacttgtta tgggggcctg      420

tcaggggtca tgaagttaga tgaccttacc tatgaaatca aacccctcaa tgattcacag      480

agctttgaac accttgtttc tcagatagta tctgagtctg atgacacagg gcctatgaat      540

gcatggaagc actggagcca taatacaggt tctccctcct ccagattgga atatgcagat      600

ggagctccca gaatatctag taagaactac gctacacatc cagctgctat aaaaggccac      660

tttcaagcaa ccaattctgt atataattct gctgcaggtg acaaactttc atctactgtt      720

gggtatttgt ttcaagtcat tagtttaatg gacacctatc tgaccaatct tcatatgcgg      780

tactatgtct ttctcatgac tgtgtacacc aattctgatc catttcgact tgagtttgca      840

gttccaggag ggtcggctta taattactat gtgtcagtct tttataataa atttaagcct      900

gatgcaggag ttttacttaa taagtatggg ccacaagata accaggttaa tccagctgag      960

aggagtatat gttcttcctt agccctaatt tgtattggta aatatgatcg aaatccttta     1020

tttttatctc ctataataac caatcgtgtt ggaaggagtt taggcttaaa atatgatgag     1080

gggtactgtg tctgccagag aaggaacacc tgcattatgt tcagacatcc tcaattaaca     1140

gatgctttca gcaattgttc ccttgcagag ataagcaaca tacttaatac tcctggtctg     1200

atgccatgtc ttttctatga ccgtcatgtt tattataata catcattgac ttataagttt     1260

tgtggaaact tcaaagtaga taacgatgag cagtgtgact gtggctccca aaaggcatgt     1320

tattcagatc cctgctgtgg aaatgattgc aggttaacac ctggtagcat ttgtgataaa     1380

gaattatgct gtgcaaattg cacttacagt ccttctggga cactctgcag acctatccag     1440

aacatatgtg atcttccaga gtactgtaat gggactaaat acatttgccc agatgacact     1500

tatctgcaag atgggacacc atgctcagaa gatggttact gctataaagg taactgcact     1560

gatcgcaaca tacaatgcat ggaaatcttt ggtgtaagtg ctaagaatgc taatattaag     1620

tgctatgaca tcaacaaaca acggtttcga tttgggcatt gtactagagc agaagaaagc     1680

ctcacattca atgcttgtgc tgatcaggac aagctgtgtg gaaggttgca gtgtaccaat     1740

gtcaccaatc ttccatattt gcaagaacat gtttcattcc atcaatcgat tatctctggg     1800

tttacctgct ttgggcttga tgaacatcgt gggacagaaa caacagatgc tggaatggtg     1860

agacatggta ccccctgctc caaaagtaag ttctgtgatc aaggagcttg cagtggaagt     1920

ttatctcatt tgggttatga ctgcacccca gaaaaatgca gttttagagg agtgtgtaac     1980

aatcatcgga attgccattg tcattttggt tggaagcctc cagagtgcaa agaagaggga     2040

ctaagtggga gcatagacag tgggtcccct ccagttcaaa ggcacacaat aaaacaaaaa     2100

caagagccag tggtgtattt aagaatactc tttggtcgta tttacttcct ctttgttgca     2160

ctgctctttg gcattgccac tcgtgtagga gttactaaga tttttagatt tgaagacttg     2220

caagctactt tacgttctgg gcaaggacca gcaagggaca agccaaagta a              2271


<210>  5
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Homology Arm:

<400>  5
tatgttgatg gatttccata tattaaacca tccctgcatc cctgggatga agcctacttg       60

gtcatgatag acgattgttt tgatgtgttc ttggattcag ttagtgagaa atatattgag      120

tatttttaca tcgatattca taagggaaat tggtctgaag ttctctttct ttgttgggtc      180

tttatgtggt ttagttatca                                                  200


<210>  6
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' Homology Arm:

<400>  6
tgattccacc agaggttctt ttatccttga gaagagtttt tgctatccta ggttttttgt       60

tattccacat gaatttgcag attgctcttt ctaattcctt gaagaattga gttggaattt      120

gatggggatt gcattaaatc tgtagattcc ttttggcaag acagccattt ttacaatgtt      180

aatcctgcca atccatgagc atgg                                             204


<210>  7
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Homology Arm:

<400>  7
tttatgtact ataccatctc agaaagtcag gttagtctca ctagcatcgt aaaagctctg       60

tctgggcttt tccatctgct ctgctttttg tctctgtgtc taaaaatata taaaccaatg      120

ttgtccagcc aaaaaaaaaa aattaaagag caaaaggagg taaaatggat acaaattgga      180

aaagaagaaa tcaaaatatc actacttgaa gatagtataa tatatttaac tgaccacaaa      240

aattccacca gaaaactcct aaacctgata aacaaactca gaaaaatggc tagatataaa      300

ctta                                                                   304


<210>  8
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' Homology Arm:

<400>  8
acccatagag agaaaacagg tgagttagtg cattaaaggg gctgagcagg gagttctcat       60

cgctccccag caccagaaat aagagcctct ccggagctgc tgggacatgg aatgcagatg      120

attcggacca tcagccccac agagaccttt cccactctgg ctcagaaaga ggcactggac      180

cacagttgga gaggagaatc gaaagctgat atctctgtat tcacttagcc tgttacccac      240

ccatgcaccc aagtccaagg tgggagaaac actgagggtc taaacacagc cccagagcaa      300

ctgccagtat taaat                                                       315


<210>  9
<211>  365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgH BAC Homology Arm:

<400>  9
attcaggcag ttaattgttg ggttcatgtt ttacaactaa agaataaatt caggccagat       60

gcagtggatc atcgctataa tcacaccact ttcagaagca aaaatgaggg aaatcccgtg      120

agacgaggca atcgaagcca acctgagcaa cataaagaga tgctatttct ctgaaaaaat      180

attttaaaga ataagcaggt gaggggtggc gttcccctct acttctagat actcaggaag      240

caaagatggg aagattatgt gagccaggtg ttcaaaatta cagtgagctt tgatcataca      300

actgttcttc aaactgtgca acagggtgag agcctgtctc taaaaacaaa taaaaaagaa      360

tcaat                                                                  365


