                         SEQUENCE LISTING

<110>  DSM IP Assets B.V.
 
<120>  Microbial strains engineered to produce ethanol from 
       carbohydrates, acetic acid and glycerol

<130>  P6038681PCT

<150>  EP 11191333
<151>  2011-11-30

<150>  US 61/564,932
<151>  2011-11-30

<160>  51    

<170>  PatentIn version 3.3

<210>  1
<211>  316
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Ser Lys Arg Lys Val Ala Ile Ile Gly Ser Gly Asn Ile Gly Thr 
1               5                   10                  15      


Asp Leu Met Ile Lys Ile Leu Arg His Gly Gln His Leu Glu Met Ala 
            20                  25                  30          


Val Met Val Gly Ile Asp Pro Gln Ser Asp Gly Leu Ala Arg Ala Arg 
        35                  40                  45              


Arg Met Gly Val Ala Thr Thr His Glu Gly Val Ile Gly Leu Met Asn 
    50                  55                  60                  


Met Pro Glu Phe Ala Asp Ile Asp Ile Val Phe Asp Ala Thr Ser Ala 
65                  70                  75                  80  


Gly Ala His Val Lys Asn Asp Ala Ala Leu Arg Glu Ala Lys Pro Asp 
                85                  90                  95      


Ile Arg Leu Ile Asp Leu Thr Pro Ala Ala Ile Gly Pro Tyr Cys Val 
            100                 105                 110         


Pro Val Val Asn Leu Glu Ala Asn Val Asp Gln Leu Asn Val Asn Met 
        115                 120                 125             


Val Thr Cys Gly Gly Gln Ala Thr Ile Pro Met Val Ala Ala Val Ser 
    130                 135                 140                 


Arg Val Ala Arg Val His Tyr Ala Glu Ile Ile Ala Ser Ile Ala Ser 
145                 150                 155                 160 


Lys Ser Ala Gly Pro Gly Thr Arg Ala Asn Ile Asp Glu Phe Thr Glu 
                165                 170                 175     


Thr Thr Ser Arg Ala Ile Glu Val Val Gly Gly Ala Ala Lys Gly Lys 
            180                 185                 190         


Ala Ile Ile Val Leu Asn Pro Ala Glu Pro Pro Leu Met Met Arg Asp 
        195                 200                 205             


Thr Val Tyr Val Leu Ser Asp Glu Ala Ser Gln Asp Asp Ile Glu Ala 
    210                 215                 220                 


Ser Ile Asn Glu Met Ala Glu Ala Val Gln Ala Tyr Val Pro Gly Tyr 
225                 230                 235                 240 


Arg Leu Lys Gln Arg Val Gln Phe Glu Val Ile Pro Gln Asp Lys Pro 
                245                 250                 255     


Val Asn Leu Pro Gly Val Gly Gln Phe Ser Gly Leu Lys Thr Ala Val 
            260                 265                 270         


Trp Leu Glu Val Glu Gly Ala Ala His Tyr Leu Pro Ala Tyr Ala Gly 
        275                 280                 285             


Asn Leu Asp Ile Met Thr Ser Ser Ala Leu Ala Thr Ala Glu Lys Met 
    290                 295                 300                 


Ala Gln Ser Leu Ala Arg Lys Ala Gly Glu Ala Ala 
305                 310                 315     


<210>  2
<211>  968
<212>  DNA
<213>  Artificial

<220>
<223>  mhpF codon optimised

<400>  2
ctgcagtcta gatgtctaag agaaaggttg ctatcatcgg ttctggtaac atcggtactg     60

acttgatgat caagatccta agacacggtc aacacttgga aatggctgtt atggttggta    120

tcgacccaca atctgacggt ttggctagag ctagaagaat gggtgttgct accacccacg    180

aaggtgttat cggtttgatg aacatgccag aattcgctga catcgacatc gttttcgacg    240

ctacctctgc tggtgctcac gttaagaacg acgctgcttt gagagaagct aagccagaca    300

tcagattgat cgacttgacc ccagctgcta tcggtccata ctgtgttcca gttgttaact    360

tggaagctaa cgttgaccaa ttaaacgtta acatggttac ctgtggtggt caagctacca    420

tcccaatggt tgctgctgtt tcaagagttg ctagagttca ctacgctgaa atcatcgctt    480

ctatcgcttc taagtctgct ggtccaggta ccagagctaa catcgacgaa ttcaccgaaa    540

ccacctctag ggctatcgaa gttgttggtg gtgctgctaa gggtaaggct atcatcgttt    600

tgaacccagc tgaaccacca ttgatgatga gagacaccgt ttacgttttg tctgacgaag    660

catctcaaga cgacatcgaa gcttcaatca acgaaatggc tgaagctgtt caagcatacg    720

ttccaggtta cagattgaag caaagagttc aattcgaagt tatcccacaa gacaagccag    780

ttaacttgcc aggtgttggt caattctctg gtttgaagac cgctgtttgg ttggaagttg    840

aaggtgctgc tcactacttg ccagcttacg ctggtaactt ggacattatg acctcttctg    900

ctttggctac cgctgaaaag atggctcaat ctttggctag aaaggctggt gaagctgctt    960

aagcgcgc                                                             968


<210>  3
<211>  891
<212>  PRT
<213>  Escherichia coli

<400>  3

Met Ala Val Thr Asn Val Ala Glu Leu Asn Ala Leu Val Glu Arg Val 
1               5                   10                  15      


Lys Lys Ala Gln Arg Glu Tyr Ala Ser Phe Thr Gln Glu Gln Val Asp 
            20                  25                  30          


Lys Ile Phe Arg Ala Ala Ala Leu Ala Ala Ala Asp Ala Arg Ile Pro 
        35                  40                  45              


Leu Ala Lys Met Ala Val Ala Glu Ser Gly Met Gly Ile Val Glu Asp 
    50                  55                  60                  


Lys Val Ile Lys Asn His Phe Ala Ser Glu Tyr Ile Tyr Asn Ala Tyr 
65                  70                  75                  80  


Lys Asp Glu Lys Thr Cys Gly Val Leu Ser Glu Asp Asp Thr Phe Gly 
                85                  90                  95      


Thr Ile Thr Ile Ala Glu Pro Ile Gly Ile Ile Cys Gly Ile Val Pro 
            100                 105                 110         


Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu 
        115                 120                 125             


Lys Thr Arg Asn Ala Ile Ile Phe Ser Pro His Pro Arg Ala Lys Asp 
    130                 135                 140                 


Ala Thr Asn Lys Ala Ala Asp Ile Val Leu Gln Ala Ala Ile Ala Ala 
145                 150                 155                 160 


Gly Ala Pro Lys Asp Leu Ile Gly Trp Ile Asp Gln Pro Ser Val Glu 
                165                 170                 175     


Leu Ser Asn Ala Leu Met His His Pro Asp Ile Asn Leu Ile Leu Ala 
            180                 185                 190         


Thr Gly Gly Pro Gly Met Val Lys Ala Ala Tyr Ser Ser Gly Lys Pro 
        195                 200                 205             


Ala Ile Gly Val Gly Ala Gly Asn Thr Pro Val Val Ile Asp Glu Thr 
    210                 215                 220                 


Ala Asp Ile Lys Arg Ala Val Ala Ser Val Leu Met Ser Lys Thr Phe 
225                 230                 235                 240 


Asp Asn Gly Val Ile Cys Ala Ser Glu Gln Ser Val Val Val Val Asp 
                245                 250                 255     


Ser Val Tyr Asp Ala Val Arg Glu Arg Phe Ala Thr His Gly Gly Tyr 
            260                 265                 270         


Leu Leu Gln Gly Lys Glu Leu Lys Ala Val Gln Asp Val Ile Leu Lys 
        275                 280                 285             


Asn Gly Ala Leu Asn Ala Ala Ile Val Gly Gln Pro Ala Tyr Lys Ile 
    290                 295                 300                 


Ala Glu Leu Ala Gly Phe Ser Val Pro Glu Asn Thr Lys Ile Leu Ile 
305                 310                 315                 320 


Gly Glu Val Thr Val Val Asp Glu Ser Glu Pro Phe Ala His Glu Lys 
                325                 330                 335     


Leu Ser Pro Thr Leu Ala Met Tyr Arg Ala Lys Asp Phe Glu Asp Ala 
            340                 345                 350         


Val Glu Lys Ala Glu Lys Leu Val Ala Met Gly Gly Ile Gly His Thr 
        355                 360                 365             


Ser Cys Leu Tyr Thr Asp Gln Asp Asn Gln Pro Ala Arg Val Ser Tyr 
    370                 375                 380                 


Phe Gly Gln Lys Met Lys Thr Ala Arg Ile Leu Ile Asn Thr Pro Ala 
385                 390                 395                 400 


Ser Gln Gly Gly Ile Gly Asp Leu Tyr Asn Phe Lys Leu Ala Pro Ser 
                405                 410                 415     


Leu Thr Leu Gly Cys Gly Ser Trp Gly Gly Asn Ser Ile Ser Glu Asn 
            420                 425                 430         


Val Gly Pro Lys His Leu Ile Asn Lys Lys Thr Val Ala Lys Arg Ala 
        435                 440                 445             


Glu Asn Met Leu Trp His Lys Leu Pro Lys Ser Ile Tyr Phe Arg Arg 
    450                 455                 460                 


Gly Ser Leu Pro Ile Ala Leu Asp Glu Val Ile Thr Asp Gly His Lys 
465                 470                 475                 480 


Arg Ala Leu Ile Val Thr Asp Arg Phe Leu Phe Asn Asn Gly Tyr Ala 
                485                 490                 495     


Asp Gln Ile Thr Ser Val Leu Lys Ala Ala Gly Val Glu Thr Glu Val 
            500                 505                 510         


Phe Phe Glu Val Glu Ala Asp Pro Thr Leu Ser Ile Val Arg Lys Gly 
        515                 520                 525             


Ala Glu Leu Ala Asn Ser Phe Lys Pro Asp Val Ile Ile Ala Leu Gly 
    530                 535                 540                 


Gly Gly Ser Pro Met Asp Ala Ala Lys Ile Met Trp Val Met Tyr Glu 
545                 550                 555                 560 


His Pro Glu Thr His Phe Glu Glu Leu Ala Leu Arg Phe Met Asp Ile 
                565                 570                 575     


Arg Lys Arg Ile Tyr Lys Phe Pro Lys Met Gly Val Lys Ala Lys Met 
            580                 585                 590         


Ile Ala Val Thr Thr Thr Ser Gly Thr Gly Ser Glu Val Thr Pro Phe 
        595                 600                 605             


Ala Val Val Thr Asp Asp Ala Thr Gly Gln Lys Tyr Pro Leu Ala Asp 
    610                 615                 620                 


Tyr Ala Leu Thr Pro Asp Met Ala Ile Val Asp Ala Asn Leu Val Met 
625                 630                 635                 640 


Asp Met Pro Lys Ser Leu Cys Ala Phe Gly Gly Leu Asp Ala Val Thr 
                645                 650                 655     


His Ala Met Glu Ala Tyr Val Ser Val Leu Ala Ser Glu Phe Ser Asp 
            660                 665                 670         


Gly Gln Ala Leu Gln Ala Leu Lys Leu Leu Lys Glu Tyr Leu Pro Ala 
        675                 680                 685             


Ser Tyr His Glu Gly Ser Lys Asn Pro Val Ala Arg Glu Arg Val His 
    690                 695                 700                 


Ser Ala Ala Thr Ile Ala Gly Ile Ala Phe Ala Asn Ala Phe Leu Gly 
705                 710                 715                 720 


Val Cys His Ser Met Ala His Lys Leu Gly Ser Gln Phe His Ile Pro 
                725                 730                 735     


His Gly Leu Ala Asn Ala Leu Leu Ile Cys Asn Val Ile Arg Tyr Asn 
            740                 745                 750         


Ala Asn Asp Asn Pro Thr Lys Gln Thr Ala Phe Ser Gln Tyr Asp Arg 
        755                 760                 765             


Pro Gln Ala Arg Arg Arg Tyr Ala Glu Ile Ala Asp His Leu Gly Leu 
    770                 775                 780                 


Ser Ala Pro Gly Asp Arg Thr Ala Ala Lys Ile Glu Lys Leu Leu Ala 
785                 790                 795                 800 


Trp Leu Glu Thr Leu Lys Ala Glu Leu Gly Ile Pro Lys Ser Ile Arg 
                805                 810                 815     


Glu Ala Gly Val Gln Glu Ala Asp Phe Leu Ala Asn Val Asp Lys Leu 
            820                 825                 830         


Ser Glu Asp Ala Phe Asp Asp Gln Cys Thr Gly Ala Asn Pro Arg Tyr 
        835                 840                 845             


Pro Leu Ile Ser Glu Leu Lys Gln Ile Leu Leu Asp Thr Tyr Tyr Gly 
    850                 855                 860                 


Arg Asp Tyr Val Glu Gly Glu Thr Ala Ala Lys Lys Glu Ala Ala Pro 
865                 870                 875                 880 


Ala Lys Ala Glu Lys Lys Ala Lys Lys Ser Ala 
                885                 890     


<210>  4
<211>  2690
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic codon optimimised adhE

<400>  4
tctagaaaat ggctgttacc aacgttgctg aattgaacgc tttggttgaa agggttaaga     60

aggctcaaag agaatacgct tctttcaccc aagaacaagt tgacaagatc ttcagagctg    120

ctgctttggc tgctgctgac gctagaatcc cattggctaa gatggctgtt gctgaatctg    180

gtatgggtat cgttgaagac aaggttatca agaaccactt cgcttctgaa tacatctaca    240

acgcttacaa ggacgaaaag acctgtggtg ttttgtcaga agacgacacc ttcggtacca    300

tcaccatcgc tgaaccaatc ggtatcatct gtggtatcgt tccaaccacc aacccaacct    360

ctaccgctat cttcaagtct ttgatctctt tgaagaccag aaacgctatc atcttctctc    420

cacacccaag agctaaagac gctaccaaca aggctgctga catcgttttg caagctgcta    480

tcgctgctgg tgctccaaag gacttgatcg gttggatcga ccaaccatct gttgaattgt    540

ctaacgcttt gatgcaccac ccagacatca acttgatctt ggctaccggt ggtccaggta    600

tggttaaggc tgcttactct tctggtaagc cagctatcgg tgttggtgct ggtaacaccc    660

cagttgttat cgacgaaacc gctgacatca agagagctgt tgcttctgtt ttgatgtcta    720

agaccttcga caacggtgtt atctgtgctt ctgaacaatc tgttgttgtt gttgactctg    780

tttacgacgc tgttagagaa agattcgcta cccacggtgg ttacttgttg caaggtaagg    840

aattgaaggc tgttcaagac gttatcttga agaacggtgc tttgaacgct gctatcgttg    900

gtcaaccagc ttacaagatc gctgaattag ctggtttctc tgttccagaa aacaccaaga    960

tcttgatcgg tgaagttacc gttgttgacg aatctgaacc attcgctcac gaaaagttgt   1020

ctccaacctt ggctatgtac agagctaagg acttcgaaga cgctgttgaa aaagctgaaa   1080

agttggttgc tatgggtggt attggtcaca cctcttgttt gtacaccgac caagacaacc   1140

aaccagctag agtttcttac ttcggtcaaa agatgaagac cgctagaatc ttgatcaaca   1200

ccccagcttc tcaaggtggt atcggtgact tgtacaactt caagttggct ccatctttga   1260

ccttgggttg tggttcttgg ggtggtaact ctatctctga aaacgttggt ccaaagcact   1320

tgatcaacaa gaagaccgtt gctaagagag ctgaaaacat gttgtggcac aagttgccaa   1380

aatctatcta cttcagaaga ggttctttgc caatcgcttt ggacgaagtt atcaccgacg   1440

gtcacaagag agctttgatc gttaccgaca gattcttgtt caacaacggt tacgctgacc   1500

aaatcacctc tgttttgaag gctgctggtg ttgaaaccga agttttcttc gaagttgaag   1560

ctgacccaac cttgtctatc gttagaaagg gtgctgaatt ggctaactct ttcaagccag   1620

acgttatcat cgctttgggt ggtggttctc caatggacgc tgctaagatc atgtgggtta   1680

tgtacgaaca cccagaaacc cacttcgaag aattggcttt gagattcatg gacatcagaa   1740

agagaatcta caagttccca aagatgggtg ttaaggctaa gatgatcgct gttaccacca   1800

cctctggtac cggttctgaa gttaccccat tcgctgttgt taccgacgac gctaccggtc   1860

aaaagtaccc attggctgac tacgctttga ccccagacat ggctatcgtt gacgctaact   1920

tggttatgga catgccaaag tctttgtgtg ctttcggtgg tttggacgct gttacccacg   1980

ctatggaagc ttacgtttct gttttggctt ctgaattctc tgacggtcaa gctttgcaag   2040

ctttgaagtt gttgaaggaa tacttgccag cttcttacca cgaaggttct aagaacccag   2100

ttgctagaga aagagttcac tctgctgcta ccatcgctgg tatcgctttc gctaacgctt   2160

tcttgggtgt ttgtcactct atggctcaca agttgggttc tcaattccac atcccacacg   2220

gtttggctaa cgctttgttg atctgtaacg ttatcagata caacgctaac gacaacccaa   2280

ccaagcaaac cgctttctct caatacgaca gaccacaagc tagaagaaga tacgctgaaa   2340

tcgctgacca cttgggtttg tctgctccag gtgacagaac cgctgcaaag atcgaaaagt   2400

tgttggcttg gttggaaacc ttgaaggctg aattgggtat cccaaagtct atcagagaag   2460

ctggtgttca agaagctgac ttcttggcta acgttgacaa gttgtctgaa gacgctttcg   2520

acgaccaatg taccggtgct aacccaagat acccattgat ctctgaattg aagcaaatct   2580

tgttggacac ctactacggt agagactacg ttgaaggtga aaccgctgct aagaaggaag   2640

ctgctccagc taaggctgaa aagaaggcta agaagtctgc ttagcttaag              2690


<210>  5
<211>  870
<212>  PRT
<213>  Entamoeba histolytica

<400>  5

Met Ser Thr Gln Gln Thr Met Thr Val Asp Glu His Ile Asn Gln Leu 
1               5                   10                  15      


Val Arg Lys Ala Gln Val Ala Leu Lys Glu Tyr Leu Lys Pro Glu Tyr 
            20                  25                  30          


Thr Gln Glu Lys Ile Asp Tyr Ile Val Lys Lys Ala Ser Val Ala Ala 
        35                  40                  45              


Leu Asp Gln His Cys Ala Leu Ala Ala Ala Ala Val Glu Glu Thr Gly 
    50                  55                  60                  


Arg Gly Ile Phe Glu Asp Lys Ala Thr Lys Asn Ile Phe Ala Cys Glu 
65                  70                  75                  80  


His Val Thr His Glu Met Arg His Ala Lys Thr Val Gly Ile Ile Asn 
                85                  90                  95      


Val Asp Pro Leu Tyr Gly Ile Thr Glu Ile Ala Glu Pro Val Gly Val 
            100                 105                 110         


Val Cys Gly Val Thr Pro Val Thr Asn Pro Thr Ser Thr Ala Ile Phe 
        115                 120                 125             


Lys Ser Leu Ile Ser Ile Lys Thr Arg Asn Pro Ile Val Phe Ser Phe 
    130                 135                 140                 


His Pro Ser Ala Leu Lys Cys Ser Ile Met Ala Ala Lys Ile Val Arg 
145                 150                 155                 160 


Asp Ala Ala Ile Ala Ala Gly Ala Pro Glu Asn Cys Ile Gln Trp Ile 
                165                 170                 175     


Glu Phe Gly Gly Ile Glu Ala Ser Asn Lys Leu Met Asn His Pro Gly 
            180                 185                 190         


Val Ala Thr Ile Leu Ala Thr Gly Gly Asn Ala Met Val Lys Ala Ala 
        195                 200                 205             


Tyr Ser Ser Gly Lys Pro Ala Leu Gly Val Gly Ala Gly Asn Val Pro 
    210                 215                 220                 


Thr Tyr Ile Glu Lys Thr Cys Asn Ile Lys Gln Ala Ala Asn Asp Val 
225                 230                 235                 240 


Val Met Ser Lys Ser Phe Asp Asn Gly Met Ile Cys Ala Ser Glu Gln 
                245                 250                 255     


Ala Ala Ile Ile Asp Lys Glu Ile Tyr Asp Gln Val Val Glu Glu Met 
            260                 265                 270         


Lys Thr Leu Gly Ala Tyr Phe Ile Asn Glu Glu Glu Lys Ala Lys Leu 
        275                 280                 285             


Glu Lys Phe Met Phe Gly Val Asn Ala Tyr Ser Ala Asp Val Asn Asn 
    290                 295                 300                 


Ala Arg Leu Asn Pro Lys Cys Pro Gly Met Ser Pro Gln Trp Phe Ala 
305                 310                 315                 320 


Glu Gln Val Gly Ile Lys Val Pro Glu Asp Cys Asn Ile Ile Cys Ala 
                325                 330                 335     


Val Cys Lys Glu Val Gly Pro Asn Glu Pro Leu Thr Arg Glu Lys Leu 
            340                 345                 350         


Ser Pro Val Leu Ala Ile Leu Lys Ala Glu Asn Thr Gln Asp Gly Ile 
        355                 360                 365             


Asp Lys Ala Glu Ala Met Val Glu Phe Asn Gly Arg Gly His Ser Ala 
    370                 375                 380                 


Ala Ile His Ser Asn Asp Lys Ala Val Val Glu Lys Tyr Ala Leu Thr 
385                 390                 395                 400 


Met Lys Ala Cys Arg Ile Leu His Asn Thr Pro Ser Ser Gln Gly Gly 
                405                 410                 415     


Ile Gly Ser Ile Tyr Asn Tyr Ile Trp Pro Ser Phe Thr Leu Gly Cys 
            420                 425                 430         


Gly Ser Tyr Gly Gly Asn Ser Val Ser Ala Asn Val Thr Tyr His Asn 
        435                 440                 445             


Leu Leu Asn Ile Lys Arg Leu Ala Asp Arg Arg Asn Asn Leu Gln Trp 
    450                 455                 460                 


Phe Arg Val Pro Pro Lys Ile Phe Phe Glu Pro His Ser Ile Arg Tyr 
465                 470                 475                 480 


Leu Ala Glu Leu Lys Glu Leu Ser Lys Ile Phe Ile Val Ser Asp Arg 
                485                 490                 495     


Met Met Tyr Lys Leu Gly Tyr Val Asp Arg Val Met Asp Val Leu Lys 
            500                 505                 510         


Arg Arg Ser Asn Glu Val Glu Ile Glu Ile Phe Ile Asp Val Glu Pro 
        515                 520                 525             


Asp Pro Ser Ile Gln Thr Val Gln Lys Gly Leu Ala Val Met Asn Thr 
    530                 535                 540                 


Phe Gly Pro Asp Asn Ile Ile Ala Ile Gly Gly Gly Ser Ala Met Asp 
545                 550                 555                 560 


Ala Ala Lys Ile Met Trp Leu Leu Tyr Glu His Pro Glu Ala Asp Phe 
                565                 570                 575     


Phe Ala Met Lys Gln Lys Phe Ile Asp Leu Arg Lys Arg Ala Phe Lys 
            580                 585                 590         


Phe Pro Thr Met Gly Lys Lys Ala Arg Leu Ile Cys Ile Pro Thr Thr 
        595                 600                 605             


Ser Gly Thr Gly Ser Glu Val Thr Pro Phe Ala Val Ile Ser Asp His 
    610                 615                 620                 


Glu Thr Gly Lys Lys Tyr Pro Leu Ala Asp Tyr Ser Leu Thr Pro Ser 
625                 630                 635                 640 


Val Ala Ile Val Asp Pro Met Phe Thr Met Ser Leu Pro Lys Arg Ala 
                645                 650                 655     


Ile Ala Asp Thr Gly Leu Asp Val Leu Val His Ala Thr Glu Ala Tyr 
            660                 665                 670         


Val Ser Val Met Ala Asn Glu Tyr Thr Asp Gly Leu Ala Arg Glu Ala 
        675                 680                 685             


Val Lys Leu Val Phe Glu Asn Leu Leu Lys Ser Tyr Asn Gly Asp Leu 
    690                 695                 700                 


Glu Ala Arg Glu Lys Met His Asn Ala Ala Thr Ile Ala Gly Met Ala 
705                 710                 715                 720 


Phe Ala Ser Ala Phe Leu Gly Met Asp His Ser Met Ala His Lys Val 
                725                 730                 735     


Gly Ala Ala Phe His Leu Pro His Gly Arg Cys Val Ala Val Leu Leu 
            740                 745                 750         


Pro His Val Ile Arg Tyr Asn Gly Gln Lys Pro Arg Lys Leu Ala Met 
        755                 760                 765             


Trp Pro Lys Tyr Asn Phe Tyr Lys Ala Asp Gln Arg Tyr Met Glu Leu 
    770                 775                 780                 


Ala Gln Met Val Gly Leu Lys Cys Asn Thr Pro Ala Glu Gly Val Glu 
785                 790                 795                 800 


Ala Phe Ala Lys Ala Cys Glu Glu Leu Met Lys Ala Thr Glu Thr Ile 
                805                 810                 815     


Thr Gly Phe Lys Lys Ala Asn Ile Asp Glu Ala Ala Trp Met Ser Lys 
            820                 825                 830         


Val Pro Glu Met Ala Leu Leu Ala Phe Glu Asp Gln Cys Ser Pro Ala 
        835                 840                 845             


Asn Pro Arg Val Pro Met Val Lys Asp Met Glu Lys Ile Leu Lys Ala 
    850                 855                 860                 


Ala Tyr Tyr Pro Ile Ala 
865                 870 


<210>  6
<211>  2627
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic codon optimised ADH2

<400>  6
tctagaaaat gtctacccaa caaaccatga ccgttgacga acacatcaac caattagtta     60

gaaaggctca agttgctttg aaggaatact tgaagccaga atacacccaa gaaaagatcg    120

actacatcgt taagaaggct tctgttgctg ctttggacca acactgtgct ttggctgctg    180

ctgctgttga agaaaccggt agaggtatct tcgaagacaa ggctaccaag aacatcttcg    240

cttgtgaaca cgttacccac gaaatgagac acgctaagac cgttggtatc atcaacgttg    300

acccattgta cggtatcacc gaaatcgctg aaccagttgg tgttgtttgt ggtgttaccc    360

cagttaccaa cccaacctct accgctatct tcaagtcttt gatctctatc aagaccagaa    420

acccaatcgt tttctctttc cacccatctg ctttgaagtg ttctattatg gctgctaaaa    480

tcgttagaga cgctgctatc gctgctggtg ctccagaaaa ctgtatccaa tggatcgaat    540

tcggtggtat cgaagcttct aacaagttga tgaaccaccc aggtgttgct actatcttgg    600

ctaccggtgg taacgctatg gttaaggctg catactcttc tggtaagcca gctttgggtg    660

ttggtgctgg taacgttcca acctacatcg aaaagacctg taacatcaag caagctgcta    720

acgacgttgt tatgtctaag tctttcgaca acggtatgat ctgtgcttct gaacaagctg    780

ctatcatcga caaggaaatc tacgaccaag ttgttgaaga aatgaagacc ttgggtgctt    840

acttcatcaa cgaagaagaa aaggctaagt tggaaaagtt catgttcggt gttaacgctt    900

actctgctga cgttaacaac gctagattga acccaaagtg tccaggtatg tctccacaat    960

ggttcgctga acaagttggt atcaaggtac cagaagactg taacatcatc tgtgctgttt   1020

gtaaggaagt tggtccaaac gaaccattga ccagagaaaa gttgtctcca gttttggcta   1080

tcttgaaagc tgaaaacacc caagacggta tcgacaaggc tgaagctatg gttgaattta   1140

acggtagagg tcactctgct gctatccact ctaacgacaa ggctgttgtt gaaaagtacg   1200

ctttgaccat gaaggcttgt agaatcttgc acaacacccc atcttctcaa ggtggtatcg   1260

gttctatcta caactacatc tggccatctt tcaccttggg ttgtggttct tacggtggta   1320

actctgtttc tgctaacgtt acctaccaca acttgttgaa catcaagaga ttggctgaca   1380

gaagaaacaa cttgcaatgg ttcagagttc caccaaagat cttcttcgaa ccacactcta   1440

tcagatactt ggctgaattg aaggaattgt ctaagatctt catcgtttct gacagaatga   1500

tgtacaagtt gggttacgtt gacagagtta tggacgtttt gaagagaaga tctaacgaag   1560

ttgaaatcga aatcttcatc gacgttgaac cagacccatc tatccaaacc gttcaaaagg   1620

gtttggctgt tatgaacacc ttcggtccag acaacatcat cgctatcggt ggtggttctg   1680

ctatggacgc tgctaagatc atgtggttgt tgtacgaaca cccagaagct gacttcttcg   1740

ctatgaagca aaagttcatc gacttgagaa agagagcttt caagttccca accatgggta   1800

agaaggctag attgatctgt atcccaacca cctctggtac cggttctgaa gttaccccat   1860

tcgctgttat ctctgaccac gaaaccggta agaagtaccc attggctgac tactctttga   1920

ccccatctgt tgctatcgtt gacccaatgt tcaccatgtc tttgccaaag agagctatcg   1980

ctgacaccgg tttggacgtt ttggttcacg ctaccgaagc ttacgtttct gttatggcta   2040

acgaatacac cgacggtttg gctagagaag ctgttaagtt ggtttttgaa aacttgttga   2100

agtcttacaa cggtgacttg gaagctagag aaaagatgca caacgctgct accatcgctg   2160

gtatggcttt cgcttctgct ttcttgggta tggaccactc tatggctcac aaggttggtg   2220

ctgctttcca cttgccacac ggtagatgtg ttgctgtttt gttgccacac gttatcagat   2280

acaacggtca aaagccaaga aagttggcta tgtggccaaa gtacaacttc tacaaggctg   2340

accaaagata catggaattg gctcaaatgg ttggtttgaa gtgtaacacc ccagctgaag   2400

gtgttgaagc tttcgctaag gcttgtgaag aattgatgaa ggctaccgaa accatcaccg   2460

gtttcaagaa ggctaacatc gacgaagctg cttggatgtc taaggttcca gaaatggctt   2520

tgttggcttt cgaagaccaa tgttctccag ctaacccaag agttccaatg gttaaggaca   2580

tggaaaagat cttgaaggct gcttactacc caatcgctta gcttaag                 2627


<210>  7
<211>  367
<212>  PRT
<213>  Escherichia coli

<400>  7

Met Asp Arg Ile Ile Gln Ser Pro Gly Lys Tyr Ile Gln Gly Ala Asp 
1               5                   10                  15      


Val Ile Asn Arg Leu Gly Glu Tyr Leu Lys Pro Leu Ala Glu Arg Trp 
            20                  25                  30          


Leu Val Val Gly Asp Lys Phe Val Leu Gly Phe Ala Gln Ser Thr Val 
        35                  40                  45              


Glu Lys Ser Phe Lys Asp Ala Gly Leu Val Val Glu Ile Ala Pro Phe 
    50                  55                  60                  


Gly Gly Glu Cys Ser Gln Asn Glu Ile Asp Arg Leu Arg Gly Ile Ala 
65                  70                  75                  80  


Glu Thr Ala Gln Cys Gly Ala Ile Leu Gly Ile Gly Gly Gly Lys Thr 
                85                  90                  95      


Leu Asp Thr Ala Lys Ala Leu Ala His Phe Met Gly Val Pro Val Ala 
            100                 105                 110         


Ile Ala Pro Thr Ile Ala Ser Thr Asp Ala Pro Cys Ser Ala Leu Ser 
        115                 120                 125             


Val Ile Tyr Thr Asp Glu Gly Glu Phe Asp Arg Tyr Leu Leu Leu Pro 
    130                 135                 140                 


Asn Asn Pro Asn Met Val Ile Val Asp Thr Lys Ile Val Ala Gly Ala 
145                 150                 155                 160 


Pro Ala Arg Leu Leu Ala Ala Gly Ile Gly Asp Ala Leu Ala Thr Trp 
                165                 170                 175     


Phe Glu Ala Arg Ala Cys Ser Arg Ser Gly Ala Thr Thr Met Ala Gly 
            180                 185                 190         


Gly Lys Cys Thr Gln Ala Ala Leu Ala Leu Ala Glu Leu Cys Tyr Asn 
        195                 200                 205             


Thr Leu Leu Glu Glu Gly Glu Lys Ala Met Leu Ala Ala Glu Gln His 
    210                 215                 220                 


Val Val Thr Pro Ala Leu Glu Arg Val Ile Glu Ala Asn Thr Tyr Leu 
225                 230                 235                 240 


Ser Gly Val Gly Phe Glu Ser Gly Gly Leu Ala Ala Ala His Ala Val 
                245                 250                 255     


His Asn Gly Leu Thr Ala Ile Pro Asp Ala His His Tyr Tyr His Gly 
            260                 265                 270         


Glu Lys Val Ala Phe Gly Thr Leu Thr Gln Leu Val Leu Glu Asn Ala 
        275                 280                 285             


Pro Val Glu Glu Ile Glu Thr Val Ala Ala Leu Ser His Ala Val Gly 
    290                 295                 300                 


Leu Pro Ile Thr Leu Ala Gln Leu Asp Ile Lys Glu Asp Val Pro Ala 
305                 310                 315                 320 


Lys Met Arg Ile Val Ala Glu Ala Ala Cys Ala Glu Gly Glu Thr Ile 
                325                 330                 335     


His Asn Met Pro Gly Gly Ala Thr Pro Asp Gln Val Tyr Ala Ala Leu 
            340                 345                 350         


Leu Val Ala Asp Gln Tyr Gly Gln Arg Phe Leu Gln Glu Trp Glu 
        355                 360                 365         


<210>  8
<211>  584
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Ser Ala Lys Ser Phe Glu Val Thr Asp Pro Val Asn Ser Ser Leu 
1               5                   10                  15      


Lys Gly Phe Ala Leu Ala Asn Pro Ser Ile Thr Leu Val Pro Glu Glu 
            20                  25                  30          


Lys Ile Leu Phe Arg Lys Thr Asp Ser Asp Lys Ile Ala Leu Ile Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly His Glu Pro Thr His Ala Gly Phe Ile Gly Lys 
    50                  55                  60                  


Gly Met Leu Ser Gly Ala Val Val Gly Glu Ile Phe Ala Ser Pro Ser 
65                  70                  75                  80  


Thr Lys Gln Ile Leu Asn Ala Ile Arg Leu Val Asn Glu Asn Ala Ser 
                85                  90                  95      


Gly Val Leu Leu Ile Val Lys Asn Tyr Thr Gly Asp Val Leu His Phe 
            100                 105                 110         


Gly Leu Ser Ala Glu Arg Ala Arg Ala Leu Gly Ile Asn Cys Arg Val 
        115                 120                 125             


Ala Val Ile Gly Asp Asp Val Ala Val Gly Arg Glu Lys Gly Gly Met 
    130                 135                 140                 


Val Gly Arg Arg Ala Leu Ala Gly Thr Val Leu Val His Lys Ile Val 
145                 150                 155                 160 


Gly Ala Phe Ala Glu Glu Tyr Ser Ser Lys Tyr Gly Leu Asp Gly Thr 
                165                 170                 175     


Ala Lys Val Ala Lys Ile Ile Asn Asp Asn Leu Val Thr Ile Gly Ser 
            180                 185                 190         


Ser Leu Asp His Cys Lys Val Pro Gly Arg Lys Phe Glu Ser Glu Leu 
        195                 200                 205             


Asn Glu Lys Gln Met Glu Leu Gly Met Gly Ile His Asn Glu Pro Gly 
    210                 215                 220                 


Val Lys Val Leu Asp Pro Ile Pro Ser Thr Glu Asp Leu Ile Ser Lys 
225                 230                 235                 240 


Tyr Met Leu Pro Lys Leu Leu Asp Pro Asn Asp Lys Asp Arg Ala Phe 
                245                 250                 255     


Val Lys Phe Asp Glu Asp Asp Glu Val Val Leu Leu Val Asn Asn Leu 
            260                 265                 270         


Gly Gly Val Ser Asn Phe Val Ile Ser Ser Ile Thr Ser Lys Thr Thr 
        275                 280                 285             


Asp Phe Leu Lys Glu Asn Tyr Asn Ile Thr Pro Val Gln Thr Ile Ala 
    290                 295                 300                 


Gly Thr Leu Met Thr Ser Phe Asn Gly Asn Gly Phe Ser Ile Thr Leu 
305                 310                 315                 320 


Leu Asn Ala Thr Lys Ala Thr Lys Ala Leu Gln Ser Asp Phe Glu Glu 
                325                 330                 335     


Ile Lys Ser Val Leu Asp Leu Leu Asn Ala Phe Thr Asn Ala Pro Gly 
            340                 345                 350         


Trp Pro Ile Ala Asp Phe Glu Lys Thr Ser Ala Pro Ser Val Asn Asp 
        355                 360                 365             


Asp Leu Leu His Asn Glu Val Thr Ala Lys Ala Val Gly Thr Tyr Asp 
    370                 375                 380                 


Phe Asp Lys Phe Ala Glu Trp Met Lys Ser Gly Ala Glu Gln Val Ile 
385                 390                 395                 400 


Lys Ser Glu Pro His Ile Thr Glu Leu Asp Asn Gln Val Gly Asp Gly 
                405                 410                 415     


Asp Cys Gly Tyr Thr Leu Val Ala Gly Val Lys Gly Ile Thr Glu Asn 
            420                 425                 430         


Leu Asp Lys Leu Ser Lys Asp Ser Leu Ser Gln Ala Val Ala Gln Ile 
        435                 440                 445             


Ser Asp Phe Ile Glu Gly Ser Met Gly Gly Thr Ser Gly Gly Leu Tyr 
    450                 455                 460                 


Ser Ile Leu Leu Ser Gly Phe Ser His Gly Leu Ile Gln Val Cys Lys 
465                 470                 475                 480 


Ser Lys Asp Glu Pro Val Thr Lys Glu Ile Val Ala Lys Ser Leu Gly 
                485                 490                 495     


Ile Ala Leu Asp Thr Leu Tyr Lys Tyr Thr Lys Ala Arg Lys Gly Ser 
            500                 505                 510         


Ser Thr Met Ile Asp Ala Leu Glu Pro Phe Val Lys Glu Phe Thr Ala 
        515                 520                 525             


Ser Lys Asp Phe Asn Lys Ala Val Lys Ala Ala Glu Glu Gly Ala Lys 
    530                 535                 540                 


Ser Thr Ala Thr Phe Glu Ala Lys Phe Gly Arg Ala Ser Tyr Val Gly 
545                 550                 555                 560 


Asp Ser Ser Gln Val Glu Asp Pro Gly Ala Val Gly Leu Cys Glu Phe 
                565                 570                 575     


Leu Lys Gly Val Gln Ser Ala Leu 
            580                 


<210>  9
<211>  591
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Ser His Lys Gln Phe Lys Ser Asp Gly Asn Ile Val Thr Pro Tyr 
1               5                   10                  15      


Leu Leu Gly Leu Ala Arg Ser Asn Pro Gly Leu Thr Val Ile Lys His 
            20                  25                  30          


Asp Arg Val Val Phe Arg Thr Ala Ser Ala Pro Asn Ser Gly Asn Pro 
        35                  40                  45              


Pro Lys Val Ser Leu Val Ser Gly Gly Gly Ser Gly His Glu Pro Thr 
    50                  55                  60                  


His Ala Gly Phe Val Gly Glu Gly Ala Leu Asp Ala Ile Ala Ala Gly 
65                  70                  75                  80  


Ala Ile Phe Ala Ser Pro Ser Thr Lys Gln Ile Tyr Ser Ala Ile Lys 
                85                  90                  95      


Ala Val Glu Ser Pro Lys Gly Thr Leu Ile Ile Val Lys Asn Tyr Thr 
            100                 105                 110         


Gly Asp Ile Ile His Phe Gly Leu Ala Ala Glu Arg Ala Lys Ala Ala 
        115                 120                 125             


Gly Met Lys Val Glu Leu Val Ala Val Gly Asp Asp Val Ser Val Gly 
    130                 135                 140                 


Lys Lys Lys Gly Ser Leu Val Gly Arg Arg Gly Leu Gly Ala Thr Val 
145                 150                 155                 160 


Leu Val His Lys Ile Ala Gly Ala Ala Ala Ser His Gly Leu Glu Leu 
                165                 170                 175     


Ala Glu Val Ala Glu Val Ala Gln Ser Val Val Asp Asn Ser Val Thr 
            180                 185                 190         


Ile Ala Ala Ser Leu Asp His Cys Thr Val Pro Gly His Lys Pro Glu 
        195                 200                 205             


Ala Ile Leu Gly Glu Asn Glu Tyr Glu Ile Gly Met Gly Ile His Asn 
    210                 215                 220                 


Glu Ser Gly Thr Tyr Lys Ser Ser Pro Leu Pro Ser Ile Ser Glu Leu 
225                 230                 235                 240 


Val Ser Gln Met Leu Pro Leu Leu Leu Asp Glu Asp Glu Asp Arg Ser 
                245                 250                 255     


Tyr Val Lys Phe Glu Pro Lys Glu Asp Val Val Leu Met Val Asn Asn 
            260                 265                 270         


Met Gly Gly Met Ser Asn Leu Glu Leu Gly Tyr Ala Ala Glu Val Ile 
        275                 280                 285             


Ser Glu Gln Leu Ile Asp Lys Tyr Gln Ile Val Pro Lys Arg Thr Ile 
    290                 295                 300                 


Thr Gly Ala Phe Ile Thr Ala Leu Asn Gly Pro Gly Phe Gly Ile Thr 
305                 310                 315                 320 


Leu Met Asn Ala Ser Lys Ala Gly Gly Asp Ile Leu Lys Tyr Phe Asp 
                325                 330                 335     


Tyr Pro Thr Thr Ala Ser Gly Trp Asn Gln Met Tyr His Ser Ala Lys 
            340                 345                 350         


Asp Trp Glu Val Leu Ala Lys Gly Gln Val Pro Thr Ala Pro Ser Leu 
        355                 360                 365             


Lys Thr Leu Arg Asn Glu Lys Gly Ser Gly Val Lys Ala Asp Tyr Asp 
    370                 375                 380                 


Thr Phe Ala Lys Ile Leu Leu Ala Gly Ile Ala Lys Ile Asn Glu Val 
385                 390                 395                 400 


Glu Pro Lys Val Thr Trp Tyr Asp Thr Ile Ala Gly Asp Gly Asp Cys 
                405                 410                 415     


Gly Thr Thr Leu Val Ser Gly Gly Glu Ala Leu Glu Glu Ala Ile Lys 
            420                 425                 430         


Asn His Thr Leu Arg Leu Glu Asp Ala Ala Leu Gly Ile Glu Asp Ile 
        435                 440                 445             


Ala Tyr Met Val Glu Asp Ser Met Gly Gly Thr Ser Gly Gly Leu Tyr 
    450                 455                 460                 


Ser Ile Tyr Leu Ser Ala Leu Ala Gln Gly Val Arg Asp Ser Gly Asp 
465                 470                 475                 480 


Lys Glu Leu Thr Ala Glu Thr Phe Lys Lys Ala Ser Asn Val Ala Leu 
                485                 490                 495     


Asp Ala Leu Tyr Lys Tyr Thr Arg Ala Arg Pro Gly Tyr Arg Thr Leu 
            500                 505                 510         


Ile Asp Ala Leu Gln Pro Phe Val Glu Ala Leu Lys Ala Gly Lys Gly 
        515                 520                 525             


Pro Arg Ala Ala Ala Gln Ala Ala Tyr Asp Gly Ala Glu Lys Thr Arg 
    530                 535                 540                 


Lys Met Asp Ala Leu Val Gly Arg Ala Ser Tyr Val Ala Lys Glu Glu 
545                 550                 555                 560 


Leu Arg Lys Leu Asp Ser Glu Gly Gly Leu Pro Asp Pro Gly Ala Val 
                565                 570                 575     


Gly Leu Ala Ala Leu Leu Asp Gly Phe Val Thr Ala Ala Gly Tyr 
            580                 585                 590     


<210>  10
<211>  560
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  10

Met Ser Leu Ile Ser Ile Leu Ser Pro Leu Ile Thr Ser Glu Gly Leu 
1               5                   10                  15      


Asp Ser Arg Ile Lys Pro Ser Pro Lys Lys Asp Ala Ser Thr Thr Thr 
            20                  25                  30          


Lys Pro Ser Leu Trp Lys Thr Thr Glu Phe Lys Phe Tyr Tyr Ile Ala 
        35                  40                  45              


Phe Leu Val Val Val Pro Leu Met Phe Tyr Ala Gly Leu Gln Ala Ser 
    50                  55                  60                  


Ser Pro Glu Asn Pro Asn Tyr Ala Arg Tyr Glu Arg Leu Leu Ser Gln 
65                  70                  75                  80  


Gly Trp Leu Phe Gly Arg Lys Val Asp Asn Ser Asp Ser Gln Tyr Arg 
                85                  90                  95      


Phe Phe Arg Asp Asn Phe Ala Leu Leu Ser Val Leu Met Leu Val His 
            100                 105                 110         


Thr Ser Ile Lys Arg Ile Val Leu Tyr Ser Thr Asn Ile Thr Lys Leu 
        115                 120                 125             


Arg Phe Asp Leu Ile Phe Gly Leu Ile Phe Leu Val Ala Ala His Gly 
    130                 135                 140                 


Val Asn Ser Ile Arg Ile Leu Ala His Met Leu Ile Leu Tyr Ala Ile 
145                 150                 155                 160 


Ala His Val Leu Lys Asn Phe Arg Arg Ile Ala Thr Ile Ser Ile Trp 
                165                 170                 175     


Ile Tyr Gly Ile Ser Thr Leu Phe Ile Asn Asp Asn Phe Arg Ala Tyr 
            180                 185                 190         


Pro Phe Gly Asn Ile Cys Ser Phe Leu Ser Pro Leu Asp His Trp Tyr 
        195                 200                 205             


Arg Gly Ile Ile Pro Arg Trp Asp Val Phe Phe Asn Phe Thr Leu Leu 
    210                 215                 220                 


Arg Val Leu Ser Tyr Asn Leu Asp Phe Leu Glu Arg Trp Glu Asn Leu 
225                 230                 235                 240 


Gln Lys Lys Lys Ser Pro Ser Tyr Glu Ser Lys Glu Ala Lys Ser Ala 
                245                 250                 255     


Ile Leu Leu Asn Glu Arg Ala Arg Leu Thr Ala Ala His Pro Ile Gln 
            260                 265                 270         


Asp Tyr Ser Leu Met Asn Tyr Ile Ala Tyr Val Thr Tyr Thr Pro Leu 
        275                 280                 285             


Phe Ile Ala Gly Pro Ile Ile Thr Phe Asn Asp Tyr Val Tyr Gln Ser 
    290                 295                 300                 


Lys His Thr Leu Pro Ser Ile Asn Phe Lys Phe Ile Phe Tyr Tyr Ala 
305                 310                 315                 320 


Val Arg Phe Val Ile Ala Leu Leu Ser Met Glu Phe Ile Leu His Phe 
                325                 330                 335     


Leu His Val Val Ala Ile Ser Lys Thr Lys Ala Trp Glu Asn Asp Thr 
            340                 345                 350         


Pro Phe Gln Ile Ser Met Ile Gly Leu Phe Asn Leu Asn Ile Ile Trp 
        355                 360                 365             


Leu Lys Leu Leu Ile Pro Trp Arg Leu Phe Arg Leu Trp Ala Leu Leu 
    370                 375                 380                 


Asp Gly Ile Asp Thr Pro Glu Asn Met Ile Arg Cys Val Asp Asn Asn 
385                 390                 395                 400 


Tyr Ser Ser Leu Ala Phe Trp Arg Ala Trp His Arg Ser Tyr Asn Lys 
                405                 410                 415     


Trp Val Val Arg Tyr Ile Tyr Ile Pro Leu Gly Gly Ser Lys Asn Arg 
            420                 425                 430         


Val Leu Thr Ser Leu Ala Val Phe Ser Phe Val Ala Ile Trp His Asp 
        435                 440                 445             


Ile Glu Leu Lys Leu Leu Leu Trp Gly Trp Leu Ile Val Leu Phe Leu 
    450                 455                 460                 


Leu Pro Glu Ile Phe Ala Thr Gln Ile Phe Ser His Tyr Thr Asp Ala 
465                 470                 475                 480 


Val Trp Tyr Arg His Val Cys Ala Val Gly Ala Val Phe Asn Ile Trp 
                485                 490                 495     


Val Met Met Ile Ala Asn Leu Phe Gly Phe Cys Leu Gly Ser Asp Gly 
            500                 505                 510         


Thr Lys Lys Leu Leu Ser Asp Met Phe Cys Thr Val Ser Gly Phe Lys 
        515                 520                 525             


Phe Val Ile Leu Ala Ser Val Ser Leu Phe Ile Ala Val Gln Ile Met 
    530                 535                 540                 


Phe Glu Ile Arg Glu Glu Glu Lys Arg His Gly Ile Tyr Leu Lys Cys 
545                 550                 555                 560 


<210>  11
<211>  609
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Met Ser Met Leu Arg Ile Trp Ser Cys Ile Val His Phe Phe Ser Val 
1               5                   10                  15      


Gln Ala Leu Asp Ser Arg Ile Lys Pro Asp Ile Glu Phe Lys Arg Arg 
            20                  25                  30          


Gln Arg Ile Phe Ile Asn Ser Ser Lys Glu Glu Asn Gly Ser Ser Ser 
        35                  40                  45              


Ser Ala Val Thr Val Thr Arg Asn Pro Val Leu Ser Ser Asn Ser Pro 
    50                  55                  60                  


Ser Pro Pro Leu Trp Asn Thr Trp Glu Phe Arg Leu Tyr Tyr Leu Ala 
65                  70                  75                  80  


Phe Thr Val Val Val Pro Phe Met Ile Lys Ala Ala Leu Ala Thr Ser 
                85                  90                  95      


Ser Glu Ser Asn Pro Asn Tyr Tyr Lys Phe Ser Gly Leu Leu Ala His 
            100                 105                 110         


Gly Trp Ile Leu Gly Arg Lys Val Asp Asn Ser Asp Pro Gln Tyr Arg 
        115                 120                 125             


Phe Phe Arg Ser Asn Phe Phe Leu Leu Ala Ile Leu Ile Leu Leu Gln 
    130                 135                 140                 


Ile Ile Leu Lys Lys Val Phe Val Lys Phe Ser Lys Ile Pro Lys Thr 
145                 150                 155                 160 


Lys Phe Asp Phe Ala Cys Gly Leu Val Phe Val Cys Phe Met Tyr Gly 
                165                 170                 175     


Ile Asn Ser Val Lys Leu Phe Thr His Ala Phe Ile Phe Phe Thr Leu 
            180                 185                 190         


Ala His Ser Leu Lys Arg Lys Arg Leu Ile Ala Ala Phe Ala Ile Trp 
        195                 200                 205             


Ser Tyr Gly Ile Phe Thr Leu Phe Ile Asn Gln Lys Met Lys Asn Leu 
    210                 215                 220                 


Pro Phe Asn Asn Ile Ala Ile Ile Leu Ser Pro Met Asp Gln Trp Tyr 
225                 230                 235                 240 


Lys Gly Ile Val Pro Arg Trp Asp Phe Phe Phe Asn Phe Thr Leu Leu 
                245                 250                 255     


Arg Leu Leu Ser Tyr Ser Met Asp Phe Leu Glu Arg Trp His Glu Gln 
            260                 265                 270         


Leu Ser Arg Gln Pro Ser Ile Asp Tyr Asp Asp Arg Arg Pro Glu Phe 
        275                 280                 285             


Arg Lys Ser Leu Ser Gly Ser Thr Leu Gln Thr Ile Tyr Glu Ser Gly 
    290                 295                 300                 


Lys Asn Val Leu Glu Glu Lys Glu Arg Leu Val Ala Glu His His Ile 
305                 310                 315                 320 


Gln Asp Tyr Asn Phe Ile Asn Phe Ile Ala Tyr Ile Thr Tyr Ala Pro 
                325                 330                 335     


Leu Phe Leu Val Gly Pro Ile Ile Thr Phe Asn Asp Tyr Leu Tyr Gln 
            340                 345                 350         


Ser Glu Asn Lys Leu Pro Ser Leu Thr Lys Lys Asn Ile Gly Phe Tyr 
        355                 360                 365             


Ala Leu Lys Val Phe Ser Ser Leu Leu Leu Met Glu Ile Ile Leu His 
    370                 375                 380                 


Tyr Ile Tyr Val Gly Ala Ile Ala Arg Thr Lys Ala Trp Asn Asn Asp 
385                 390                 395                 400 


Thr Pro Leu Gln Gln Ala Met Ile Ala Leu Phe Asn Leu Asn Ile Met 
                405                 410                 415     


Tyr Leu Lys Leu Leu Ile Pro Trp Arg Leu Phe Arg Leu Trp Ala Met 
            420                 425                 430         


Val Asp Gly Ile Asp Ala Pro Glu Asn Met Leu Arg Cys Val Asp Asn 
        435                 440                 445             


Asn Tyr Ser Thr Val Gly Phe Trp Arg Ala Trp His Thr Ser Phe Asn 
    450                 455                 460                 


Lys Trp Val Ile Arg Tyr Ile Tyr Val Pro Phe Gly Gly Ser Asn Asn 
465                 470                 475                 480 


Lys Ile Leu Thr Ser Phe Ala Val Phe Ser Phe Val Ala Ile Trp His 
                485                 490                 495     


Asp Ile Gln Leu Arg Val Leu Phe Trp Gly Trp Leu Thr Val Leu Leu 
            500                 505                 510         


Leu Leu Gly Glu Thr Tyr Ile Thr Asn Cys Phe Ser Arg Tyr Arg Phe 
        515                 520                 525             


Arg Ser Trp Tyr Arg Phe Val Cys Gly Ile Gly Ala Ala Ile Asn Ile 
    530                 535                 540                 


Cys Met Met Met Ile Ile Asn Val Tyr Gly Phe Cys Leu Gly Ala Glu 
545                 550                 555                 560 


Gly Thr Lys Leu Leu Leu Lys Gly Ile Phe Asn Asn Ser His Ser Pro 
                565                 570                 575     


Glu Phe Leu Thr Ala Val Met Val Ser Leu Phe Ile Ala Val Gln Val 
            580                 585                 590         


Met Phe Glu Ile Arg Glu Glu Glu Lys Arg His Gly Ile Asn Leu Lys 
        595                 600                 605             


Cys 
    


<210>  12
<211>  669
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  12

Met Ser Asn Pro Gln Lys Ala Leu Asn Asp Phe Leu Ser Ser Glu Ser 
1               5                   10                  15      


Val His Thr His Asp Ser Ser Arg Lys Gln Ser Asn Lys Gln Ser Ser 
            20                  25                  30          


Asp Glu Gly Arg Ser Ser Ser Gln Pro Ser His His His Ser Gly Gly 
        35                  40                  45              


Thr Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Ser Asn Asn 
    50                  55                  60                  


Asn Asn Asn Gly Asn Asp Gly Gly Asn Asp Asp Asp Tyr Asp Tyr Glu 
65                  70                  75                  80  


Met Gln Asp Tyr Arg Pro Ser Pro Gln Ser Ala Arg Pro Thr Pro Thr 
                85                  90                  95      


Tyr Val Pro Gln Tyr Ser Val Glu Ser Gly Thr Ala Phe Pro Ile Gln 
            100                 105                 110         


Glu Val Ile Pro Ser Ala Tyr Ile Asn Thr Gln Asp Ile Asn His Lys 
        115                 120                 125             


Asp Asn Gly Pro Pro Ser Ala Ser Ser Asn Arg Ala Phe Arg Pro Arg 
    130                 135                 140                 


Gly Gln Thr Thr Val Ser Ala Asn Val Leu Asn Ile Glu Asp Phe Tyr 
145                 150                 155                 160 


Lys Asn Ala Asp Asp Ala His Thr Ile Pro Glu Ser His Leu Ser Arg 
                165                 170                 175     


Arg Arg Ser Arg Ser Arg Ala Thr Ser Asn Ala Gly His Ser Ala Asn 
            180                 185                 190         


Thr Gly Ala Thr Asn Gly Arg Thr Thr Gly Ala Gln Thr Asn Met Glu 
        195                 200                 205             


Ser Asn Glu Ser Pro Arg Asn Val Pro Ile Met Val Lys Pro Lys Thr 
    210                 215                 220                 


Leu Tyr Gln Asn Pro Gln Thr Pro Thr Val Leu Pro Ser Thr Tyr His 
225                 230                 235                 240 


Pro Ile Asn Lys Trp Ser Ser Val Lys Asn Thr Tyr Leu Lys Glu Phe 
                245                 250                 255     


Leu Ala Glu Phe Met Gly Thr Met Val Met Ile Ile Phe Gly Ser Ala 
            260                 265                 270         


Val Val Cys Gln Val Asn Val Ala Gly Lys Ile Gln Gln Asp Asn Phe 
        275                 280                 285             


Asn Val Ala Leu Asp Asn Leu Asn Val Thr Gly Ser Ser Ala Glu Thr 
    290                 295                 300                 


Ile Asp Ala Met Lys Ser Leu Thr Ser Leu Val Ser Ser Val Ala Gly 
305                 310                 315                 320 


Gly Thr Phe Asp Asp Val Ala Leu Gly Trp Ala Ala Ala Val Val Met 
                325                 330                 335     


Gly Tyr Phe Cys Ala Gly Gly Ser Ala Ile Ser Gly Ala His Leu Asn 
            340                 345                 350         


Pro Ser Ile Thr Leu Ala Asn Leu Val Tyr Arg Gly Phe Pro Leu Lys 
        355                 360                 365             


Lys Val Pro Tyr Tyr Phe Ala Gly Gln Leu Ile Gly Ala Phe Thr Gly 
    370                 375                 380                 


Ala Leu Ile Leu Phe Ile Trp Tyr Lys Arg Val Leu Gln Glu Ala Tyr 
385                 390                 395                 400 


Ser Asp Trp Trp Met Asn Glu Ser Val Ala Gly Met Phe Cys Val Phe 
                405                 410                 415     


Pro Lys Pro Tyr Leu Ser Ser Gly Arg Gln Phe Phe Ser Glu Phe Leu 
            420                 425                 430         


Cys Gly Ala Met Leu Gln Ala Gly Thr Phe Ala Leu Thr Asp Pro Tyr 
        435                 440                 445             


Thr Cys Leu Ser Ser Asp Val Phe Pro Leu Met Met Phe Ile Leu Ile 
    450                 455                 460                 


Phe Ile Ile Asn Ala Ser Met Ala Tyr Gln Thr Gly Thr Ala Met Asn 
465                 470                 475                 480 


Leu Ala Arg Asp Leu Gly Pro Arg Leu Ala Leu Tyr Ala Val Gly Phe 
                485                 490                 495     


Asp His Lys Met Leu Trp Val His His His His Phe Phe Trp Val Pro 
            500                 505                 510         


Met Val Gly Pro Phe Ile Gly Ala Leu Met Gly Gly Leu Val Tyr Asp 
        515                 520                 525             


Val Cys Ile Tyr Gln Gly His Glu Ser Pro Val Asn Trp Ser Leu Pro 
    530                 535                 540                 


Val Tyr Lys Glu Met Ile Met Arg Ala Trp Phe Arg Arg Pro Gly Trp 
545                 550                 555                 560 


Lys Lys Arg Asn Arg Ala Arg Arg Thr Ser Asp Leu Ser Asp Phe Ser 
                565                 570                 575     


Tyr Asn Asn Asp Asp Asp Glu Glu Phe Gly Glu Arg Met Ala Leu Gln 
            580                 585                 590         


Lys Thr Lys Thr Lys Ser Ser Ile Ser Asp Asn Glu Asn Glu Ala Gly 
        595                 600                 605             


Glu Lys Lys Val Gln Phe Lys Ser Val Gln Arg Gly Lys Arg Thr Phe 
    610                 615                 620                 


Gly Gly Ile Pro Thr Ile Leu Glu Glu Glu Asp Ser Ile Glu Thr Ala 
625                 630                 635                 640 


Ser Leu Gly Ala Thr Thr Thr Asp Ser Ile Gly Leu Ser Asp Thr Ser 
                645                 650                 655     


Ser Glu Asp Ser His Tyr Gly Asn Ala Lys Lys Val Thr 
            660                 665                 


<210>  13
<211>  713
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Ser Pro Ser Ala Val Gln Ser Ser Lys Leu Glu Glu Gln Ser Ser 
1               5                   10                  15      


Glu Ile Asp Lys Leu Lys Ala Lys Met Ser Gln Ser Ala Ala Thr Ala 
            20                  25                  30          


Gln Gln Lys Lys Glu His Glu Tyr Glu His Leu Thr Ser Val Lys Ile 
        35                  40                  45              


Val Pro Gln Arg Pro Ile Ser Asp Arg Leu Gln Pro Ala Ile Ala Thr 
    50                  55                  60                  


His Tyr Ser Pro His Leu Asp Gly Leu Gln Asp Tyr Gln Arg Leu His 
65                  70                  75                  80  


Lys Glu Ser Ile Glu Asp Pro Ala Lys Phe Phe Gly Ser Lys Ala Thr 
                85                  90                  95      


Gln Phe Leu Asn Trp Ser Lys Pro Phe Asp Lys Val Phe Ile Pro Asp 
            100                 105                 110         


Pro Lys Thr Gly Arg Pro Ser Phe Gln Asn Asn Ala Trp Phe Leu Asn 
        115                 120                 125             


Gly Gln Leu Asn Ala Cys Tyr Asn Cys Val Asp Arg His Ala Leu Lys 
    130                 135                 140                 


Thr Pro Asn Lys Lys Ala Ile Ile Phe Glu Gly Asp Glu Pro Gly Gln 
145                 150                 155                 160 


Gly Tyr Ser Ile Thr Tyr Lys Glu Leu Leu Glu Glu Val Cys Gln Val 
                165                 170                 175     


Ala Gln Val Leu Thr Tyr Ser Met Gly Val Arg Lys Gly Asp Thr Val 
            180                 185                 190         


Ala Val Tyr Met Pro Met Val Pro Glu Ala Ile Ile Thr Leu Leu Ala 
        195                 200                 205             


Ile Ser Arg Ile Gly Ala Ile His Ser Val Val Phe Ala Gly Phe Ser 
    210                 215                 220                 


Ser Asn Ser Leu Arg Asp Arg Ile Asn Asp Gly Asp Ser Lys Val Val 
225                 230                 235                 240 


Ile Thr Thr Asp Glu Ser Asn Arg Gly Gly Lys Val Ile Glu Thr Lys 
                245                 250                 255     


Arg Ile Val Asp Asp Ala Leu Arg Glu Thr Pro Gly Val Arg His Val 
            260                 265                 270         


Leu Val Tyr Arg Lys Thr Asn Asn Pro Ser Val Ala Phe His Ala Pro 
        275                 280                 285             


Arg Asp Leu Asp Trp Ala Thr Glu Lys Lys Lys Tyr Lys Thr Tyr Tyr 
    290                 295                 300                 


Pro Cys Thr Pro Val Asp Ser Glu Asp Pro Leu Phe Leu Leu Tyr Thr 
305                 310                 315                 320 


Ser Gly Ser Thr Gly Ala Pro Lys Gly Val Gln His Ser Thr Ala Gly 
                325                 330                 335     


Tyr Leu Leu Gly Ala Leu Leu Thr Met Arg Tyr Thr Phe Asp Thr His 
            340                 345                 350         


Gln Glu Asp Val Phe Phe Thr Ala Gly Asp Ile Gly Trp Ile Thr Gly 
        355                 360                 365             


His Thr Tyr Val Val Tyr Gly Pro Leu Leu Tyr Gly Cys Ala Thr Leu 
    370                 375                 380                 


Val Phe Glu Gly Thr Pro Ala Tyr Pro Asn Tyr Ser Arg Tyr Trp Asp 
385                 390                 395                 400 


Ile Ile Asp Glu His Lys Val Thr Gln Phe Tyr Val Ala Pro Thr Ala 
                405                 410                 415     


Leu Arg Leu Leu Lys Arg Ala Gly Asp Ser Tyr Ile Glu Asn His Ser 
            420                 425                 430         


Leu Lys Ser Leu Arg Cys Leu Gly Ser Val Gly Glu Pro Ile Ala Ala 
        435                 440                 445             


Glu Val Trp Glu Trp Tyr Ser Glu Lys Ile Gly Lys Asn Glu Ile Pro 
    450                 455                 460                 


Ile Val Asp Thr Tyr Trp Gln Thr Glu Ser Gly Ser His Leu Val Thr 
465                 470                 475                 480 


Pro Leu Ala Gly Gly Val Thr Pro Met Lys Pro Gly Ser Ala Ser Phe 
                485                 490                 495     


Pro Phe Phe Gly Ile Asp Ala Val Val Leu Asp Pro Asn Thr Gly Glu 
            500                 505                 510         


Glu Leu Asn Thr Ser His Ala Glu Gly Val Leu Ala Val Lys Ala Ala 
        515                 520                 525             


Trp Pro Ser Phe Ala Arg Thr Ile Trp Lys Asn His Asp Arg Tyr Leu 
    530                 535                 540                 


Asp Thr Tyr Leu Asn Pro Tyr Pro Gly Tyr Tyr Phe Thr Gly Asp Gly 
545                 550                 555                 560 


Ala Ala Lys Asp Lys Asp Gly Tyr Ile Trp Ile Leu Gly Arg Val Asp 
                565                 570                 575     


Asp Val Val Asn Val Ser Gly His Arg Leu Ser Thr Ala Glu Ile Glu 
            580                 585                 590         


Ala Ala Ile Ile Glu Asp Pro Ile Val Ala Glu Cys Ala Val Val Gly 
        595                 600                 605             


Phe Asn Asp Asp Leu Thr Gly Gln Ala Val Ala Ala Phe Val Val Leu 
    610                 615                 620                 


Lys Asn Lys Ser Ser Trp Ser Thr Ala Thr Asp Asp Glu Leu Gln Asp 
625                 630                 635                 640 


Ile Lys Lys His Leu Val Phe Thr Val Arg Lys Asp Ile Gly Pro Phe 
                645                 650                 655     


Ala Ala Pro Lys Leu Ile Ile Leu Val Asp Asp Leu Pro Lys Thr Arg 
            660                 665                 670         


Ser Gly Lys Ile Met Arg Arg Ile Leu Arg Lys Ile Leu Ala Gly Glu 
        675                 680                 685             


Ser Asp Gln Leu Gly Asp Val Ser Thr Leu Ser Asn Pro Gly Ile Val 
    690                 695                 700                 


Arg His Leu Ile Asp Ser Val Lys Leu 
705                 710             


<210>  14
<211>  683
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Thr Ile Lys Glu His Lys Val Val Tyr Glu Ala His Asn Val Lys 
1               5                   10                  15      


Ala Leu Lys Ala Pro Gln His Phe Tyr Asn Ser Gln Pro Gly Lys Gly 
            20                  25                  30          


Tyr Val Thr Asp Met Gln His Tyr Gln Glu Met Tyr Gln Gln Ser Ile 
        35                  40                  45              


Asn Glu Pro Glu Lys Phe Phe Asp Lys Met Ala Lys Glu Tyr Leu His 
    50                  55                  60                  


Trp Asp Ala Pro Tyr Thr Lys Val Gln Ser Gly Ser Leu Asn Asn Gly 
65                  70                  75                  80  


Asp Val Ala Trp Phe Leu Asn Gly Lys Leu Asn Ala Ser Tyr Asn Cys 
                85                  90                  95      


Val Asp Arg His Ala Phe Ala Asn Pro Asp Lys Pro Ala Leu Ile Tyr 
            100                 105                 110         


Glu Ala Asp Asp Glu Ser Asp Asn Lys Ile Ile Thr Phe Gly Glu Leu 
        115                 120                 125             


Leu Arg Lys Val Ser Gln Ile Ala Gly Val Leu Lys Ser Trp Gly Val 
    130                 135                 140                 


Lys Lys Gly Asp Thr Val Ala Ile Tyr Leu Pro Met Ile Pro Glu Ala 
145                 150                 155                 160 


Val Ile Ala Met Leu Ala Val Ala Arg Ile Gly Ala Ile His Ser Val 
                165                 170                 175     


Val Phe Ala Gly Phe Ser Ala Gly Ser Leu Lys Asp Arg Val Val Asp 
            180                 185                 190         


Ala Asn Ser Lys Val Val Ile Thr Cys Asp Glu Gly Lys Arg Gly Gly 
        195                 200                 205             


Lys Thr Ile Asn Thr Lys Lys Ile Val Asp Glu Gly Leu Asn Gly Val 
    210                 215                 220                 


Asp Leu Val Ser Arg Ile Leu Val Phe Gln Arg Thr Gly Thr Glu Gly 
225                 230                 235                 240 


Ile Pro Met Lys Ala Gly Arg Asp Tyr Trp Trp His Glu Glu Ala Ala 
                245                 250                 255     


Lys Gln Arg Thr Tyr Leu Pro Pro Val Ser Cys Asp Ala Glu Asp Pro 
            260                 265                 270         


Leu Phe Leu Leu Tyr Thr Ser Gly Ser Thr Gly Ser Pro Lys Gly Val 
        275                 280                 285             


Val His Thr Thr Gly Gly Tyr Leu Leu Gly Ala Ala Leu Thr Thr Arg 
    290                 295                 300                 


Tyr Val Phe Asp Ile His Pro Glu Asp Val Leu Phe Thr Ala Gly Asp 
305                 310                 315                 320 


Val Gly Trp Ile Thr Gly His Thr Tyr Ala Leu Tyr Gly Pro Leu Thr 
                325                 330                 335     


Leu Gly Thr Ala Ser Ile Ile Phe Glu Ser Thr Pro Ala Tyr Pro Asp 
            340                 345                 350         


Tyr Gly Arg Tyr Trp Arg Ile Ile Gln Arg His Lys Ala Thr His Phe 
        355                 360                 365             


Tyr Val Ala Pro Thr Ala Leu Arg Leu Ile Lys Arg Val Gly Glu Ala 
    370                 375                 380                 


Glu Ile Ala Lys Tyr Asp Thr Ser Ser Leu Arg Val Leu Gly Ser Val 
385                 390                 395                 400 


Gly Glu Pro Ile Ser Pro Asp Leu Trp Glu Trp Tyr His Glu Lys Val 
                405                 410                 415     


Gly Asn Lys Asn Cys Val Ile Cys Asp Thr Met Trp Gln Thr Glu Ser 
            420                 425                 430         


Gly Ser His Leu Ile Ala Pro Leu Ala Gly Ala Val Pro Thr Lys Pro 
        435                 440                 445             


Gly Ser Ala Thr Val Pro Phe Phe Gly Ile Asn Ala Cys Ile Ile Asp 
    450                 455                 460                 


Pro Val Thr Gly Val Glu Leu Glu Gly Asn Asp Val Glu Gly Val Leu 
465                 470                 475                 480 


Ala Val Lys Ser Pro Trp Pro Ser Met Ala Arg Ser Val Trp Asn His 
                485                 490                 495     


His Asp Arg Tyr Met Asp Thr Tyr Leu Lys Pro Tyr Pro Gly His Tyr 
            500                 505                 510         


Phe Thr Gly Asp Gly Ala Gly Arg Asp His Asp Gly Tyr Tyr Trp Ile 
        515                 520                 525             


Arg Gly Arg Val Asp Asp Val Val Asn Val Ser Gly His Arg Leu Ser 
    530                 535                 540                 


Thr Ser Glu Ile Glu Ala Ser Ile Ser Asn His Glu Asn Val Ser Glu 
545                 550                 555                 560 


Ala Ala Val Val Gly Ile Pro Asp Glu Leu Thr Gly Gln Thr Val Val 
                565                 570                 575     


Ala Tyr Val Ser Leu Lys Asp Gly Tyr Leu Gln Asn Asn Ala Thr Glu 
            580                 585                 590         


Gly Asp Ala Glu His Ile Thr Pro Asp Asn Leu Arg Arg Glu Leu Ile 
        595                 600                 605             


Leu Gln Val Arg Gly Glu Ile Gly Pro Phe Ala Ser Pro Lys Thr Ile 
    610                 615                 620                 


Ile Leu Val Arg Asp Leu Pro Arg Thr Arg Ser Gly Lys Ile Met Arg 
625                 630                 635                 640 


Arg Val Leu Arg Lys Val Ala Ser Asn Glu Ala Glu Gln Leu Gly Asp 
                645                 650                 655     


Leu Thr Thr Leu Ala Asn Pro Glu Val Val Pro Ala Ile Ile Ser Ala 
            660                 665                 670         


Val Glu Asn Gln Phe Phe Ser Gln Lys Lys Lys 
        675                 680             


<210>  15
<211>  384
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Thr Ala His Thr Asn Ile Lys Gln His Lys His Cys His Glu Asp 
1               5                   10                  15      


His Pro Ile Arg Arg Ser Asp Ser Ala Val Ser Ile Val His Leu Lys 
            20                  25                  30          


Arg Ala Pro Phe Lys Val Thr Val Ile Gly Ser Gly Asn Trp Gly Thr 
        35                  40                  45              


Thr Ile Ala Lys Val Ile Ala Glu Asn Thr Glu Leu His Ser His Ile 
    50                  55                  60                  


Phe Glu Pro Glu Val Arg Met Trp Val Phe Asp Glu Lys Ile Gly Asp 
65                  70                  75                  80  


Glu Asn Leu Thr Asp Ile Ile Asn Thr Arg His Gln Asn Val Lys Tyr 
                85                  90                  95      


Leu Pro Asn Ile Asp Leu Pro His Asn Leu Val Ala Asp Pro Asp Leu 
            100                 105                 110         


Leu His Ser Ile Lys Gly Ala Asp Ile Leu Val Phe Asn Ile Pro His 
        115                 120                 125             


Gln Phe Leu Pro Asn Ile Val Lys Gln Leu Gln Gly His Val Ala Pro 
    130                 135                 140                 


His Val Arg Ala Ile Ser Cys Leu Lys Gly Phe Glu Leu Gly Ser Lys 
145                 150                 155                 160 


Gly Val Gln Leu Leu Ser Ser Tyr Val Thr Asp Glu Leu Gly Ile Gln 
                165                 170                 175     


Cys Gly Ala Leu Ser Gly Ala Asn Leu Ala Pro Glu Val Ala Lys Glu 
            180                 185                 190         


His Trp Ser Glu Thr Thr Val Ala Tyr Gln Leu Pro Lys Asp Tyr Gln 
        195                 200                 205             


Gly Asp Gly Lys Asp Val Asp His Lys Ile Leu Lys Leu Leu Phe His 
    210                 215                 220                 


Arg Pro Tyr Phe His Val Asn Val Ile Asp Asp Val Ala Gly Ile Ser 
225                 230                 235                 240 


Ile Ala Gly Ala Leu Lys Asn Val Val Ala Leu Ala Cys Gly Phe Val 
                245                 250                 255     


Glu Gly Met Gly Trp Gly Asn Asn Ala Ser Ala Ala Ile Gln Arg Leu 
            260                 265                 270         


Gly Leu Gly Glu Ile Ile Lys Phe Gly Arg Met Phe Phe Pro Glu Ser 
        275                 280                 285             


Lys Val Glu Thr Tyr Tyr Gln Glu Ser Ala Gly Val Ala Asp Leu Ile 
    290                 295                 300                 


Thr Thr Cys Ser Gly Gly Arg Asn Val Lys Val Ala Thr Tyr Met Ala 
305                 310                 315                 320 


Lys Thr Gly Lys Ser Ala Leu Glu Ala Glu Lys Glu Leu Leu Asn Gly 
                325                 330                 335     


Gln Ser Ala Gln Gly Ile Ile Thr Cys Arg Glu Val His Glu Trp Leu 
            340                 345                 350         


Gln Thr Cys Glu Leu Thr Gln Glu Phe Pro Ile Ile Arg Gly Ser Leu 
        355                 360                 365             


Pro Asp Ser Leu Gln Gln Arg Pro His Gly Arg Pro Thr Gly Asp Asp 
    370                 375                 380                 


<210>  16
<211>  391
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  16

Met Ser Ala Ala Ala Asp Arg Leu Asn Leu Thr Ser Gly His Leu Asn 
1               5                   10                  15      


Ala Gly Arg Lys Arg Ser Ser Ser Ser Val Ser Leu Lys Ala Ala Glu 
            20                  25                  30          


Lys Pro Phe Lys Val Thr Val Ile Gly Ser Gly Asn Trp Gly Thr Thr 
        35                  40                  45              


Ile Ala Lys Val Val Ala Glu Asn Cys Lys Gly Tyr Pro Glu Val Phe 
    50                  55                  60                  


Ala Pro Ile Val Gln Met Trp Val Phe Glu Glu Glu Ile Asn Gly Glu 
65                  70                  75                  80  


Lys Leu Thr Glu Ile Ile Asn Thr Arg His Gln Asn Val Lys Tyr Leu 
                85                  90                  95      


Pro Gly Ile Thr Leu Pro Asp Asn Leu Val Ala Asn Pro Asp Leu Ile 
            100                 105                 110         


Asp Ser Val Lys Asp Val Asp Ile Ile Val Phe Asn Ile Pro His Gln 
        115                 120                 125             


Phe Leu Pro Arg Ile Cys Ser Gln Leu Lys Gly His Val Asp Ser His 
    130                 135                 140                 


Val Arg Ala Ile Ser Cys Leu Lys Gly Phe Glu Val Gly Ala Lys Gly 
145                 150                 155                 160 


Val Gln Leu Leu Ser Ser Tyr Ile Thr Glu Glu Leu Gly Ile Gln Cys 
                165                 170                 175     


Gly Ala Leu Ser Gly Ala Asn Ile Ala Thr Glu Val Ala Gln Glu His 
            180                 185                 190         


Trp Ser Glu Thr Thr Val Ala Tyr His Ile Pro Lys Asp Phe Arg Gly 
        195                 200                 205             


Glu Gly Lys Asp Val Asp His Lys Val Leu Lys Ala Leu Phe His Arg 
    210                 215                 220                 


Pro Tyr Phe His Val Ser Val Ile Glu Asp Val Ala Gly Ile Ser Ile 
225                 230                 235                 240 


Cys Gly Ala Leu Lys Asn Val Val Ala Leu Gly Cys Gly Phe Val Glu 
                245                 250                 255     


Gly Leu Gly Trp Gly Asn Asn Ala Ser Ala Ala Ile Gln Arg Val Gly 
            260                 265                 270         


Leu Gly Glu Ile Ile Arg Phe Gly Gln Met Phe Phe Pro Glu Ser Arg 
        275                 280                 285             


Glu Glu Thr Tyr Tyr Gln Glu Ser Ala Gly Val Ala Asp Leu Ile Thr 
    290                 295                 300                 


Thr Cys Ala Gly Gly Arg Asn Val Lys Val Ala Arg Leu Met Ala Thr 
305                 310                 315                 320 


Ser Gly Lys Asp Ala Trp Glu Cys Glu Lys Glu Leu Leu Asn Gly Gln 
                325                 330                 335     


Ser Ala Gln Gly Leu Ile Thr Cys Lys Glu Val His Glu Trp Leu Glu 
            340                 345                 350         


Thr Cys Gly Ser Val Glu Asp Phe Pro Leu Phe Glu Ala Val Tyr Gln 
        355                 360                 365             


Ile Val Tyr Asn Asn Tyr Pro Met Lys Asn Leu Pro Asp Met Ile Glu 
    370                 375                 380                 


Glu Leu Asp Leu His Glu Asp 
385                 390     


<210>  17
<211>  2573
<212>  DNA
<213>  Artificial

<220>
<223>  GDP1 disruption

<400>  17
ggtacccccg ccttgcttct ctccccttcc ttttcttttt ccagttttcc ctattttgtc     60

cctttttccg cacaacaagt atcagaatgg gttcatcaaa tctatccaac ctaattcgca    120

cgtagactgg cttggtattg gcagtttcgt agttatatat atactaccat gagtgaaact    180

gttacgttac cttaaattct ttctcccttt aattttcttt tatcttactc tcctacataa    240

gacatcaaga aacaattgta tattgtacac cccccccctc cacaaacaca aatattgata    300

atataaagat gtctgctgct gctgatagat taaacttaac ttccggccac ttgaatctag    360

atgcatgctc gagcggccgc cagtgtgatg gatatctgca gaattcgccc ttttgggccc    420

tgtacaccta ggatccgtcg acactggatg gcggcgttag tatcgaatcg acagcagtat    480

agcgaccagc attcacatac gattgacgca tgatattact ttctgcgcac ttaacttcgc    540

atctgggcag atgatgtcga ggcgaaaaaa aatataaatc acgctaacat ttgattaaaa    600

tagaacaact acaatataaa aaaactatac aaatgacaag ttcttgaaaa caagaatctt    660

tttattgtca gtactgatta ttcctttgcc ctcggacgag tgctggggcg tcggtttcca    720

ctatcggcga gtacttctac acagccatcg gtccagacgg ccgcgcttct gcgggcgatt    780

tgtgtacgcc cgacagtccc ggctccggat cggacgattg cgtcgcatcg accctgcgcc    840

caagctgcat catcgaaatt gccgtcaacc aagctctgat agagttggtc aagaccaatg    900

cggagcatat acgcccggag ccgcggcgat cctgcaagct ccggatgcct ccgctcgaag    960

tagcgcgtct gctgctccat acaagccaac cacggcctcc agaagaagat gttggcgacc   1020

tcgtattggg aatccccgaa catcgcctcg ctccagtcaa tgaccgctgt tatgcggcca   1080

ttgtccgtca ggacattgtt ggagccgaaa tccgcgtgca cgaggtgccg gacttcgggg   1140

cagtcctcgg cccaaagcat cagctcatcg agagcctgcg cgacggacgc actgacggtg   1200

tcgtccatca cagtttgcca gtgatacaca tggggatcag caatcgcgca tatgaaatca   1260

cgccatgtag tgtattgacc gattccttgc ggtccgaatg ggccgaaccc gctcgtctgg   1320

ctaagatcgg ccgcagcgat cgcatccatg gcctccgcga ccggctgcag aacagcgggc   1380

agttcggttt caggcaggtc ttgcaacgtg acaccctgtg cacggcggga gatgcaatag   1440

gtcaggctct cgctgaattc cccaatgtca agcacttccg gaatcgggag cgcggccgat   1500

gcaaagtgcc gataaacata acgatctttg tagaaaccat cggcgcagct atttacccgc   1560

aggacatatc cacgccctcc tacatcgaag ctgaaagcac gagattcttc gccctccgag   1620

agctgcatca ggtcggagac gctgtcgaac ttttcgatca gaaacttctc gacagacgtc   1680

gcggtgagtt caggcttttt acccatggtt gtttatgttc ggatgtgatg tgagaactgt   1740

atcctagcaa gattttaaaa ggaagtatat gaaagaagaa cctcagtggc aaatcctaac   1800

cttttatatt tctctacagg ggcgcggcgt ggggacaatt cacgcgtctg tgaggggagc   1860

gtttccctgc tcgcaggtct gcagcgagga gccgtaattt ttgcttcgcg ccgtgcggcc   1920

atcaaaatgt atggatgcaa atgattatac atggggatgt atgggctaaa tgtacgggcg   1980

acagtcacat catgcccctg agctgcgcac gtcaagactg tcaaggaggg tattctgggc   2040

ctccatgtcg ctggccgggt gacccggcgg ggacgaggcc ttaagttcga acgtacggag   2100

ttgttgaatg gccaatccgc tcaaggttta attacctgca aagaagttca cgaatggttg   2160

gaaacatgtg gctctgtcga agacttccca ttatttgaag ccgtatacca aatcgtttac   2220

aacaactacc caatgaagaa cctgccggac atgattgaag aattagatct acatgaagat   2280

tagatttatt ggagaaagat aacatatcat actttccccc acttttttcg aggctcttct   2340

atatcatatt cataaattag cattatgtca tttctcataa ctactttatc acgttagaaa   2400

ttacttatta ttattaaatt aatacaaaat ttagtaacca aataaatata aataaatatg   2460

tatatttaaa ttttaaaaaa aaaatcctat agagcaaaag gattttccat tataatatta   2520

gctgtacacc tcttccgcat tttttgaggg tggttacaac accactcggt acc          2573


<210>  18
<211>  2058
<212>  DNA
<213>  Artificial

<220>
<223>  GPD2 disruption

<400>  18
agatcttttg cggcgaggtg ccgatgggtt gctgagggga agagtgttta gcttacggac     60

ctattgccat tgttattccg attaatctat tgttcagcag ctcttctcta ccctgtcatt    120

ctagtatttt tttttttttt ttttggtttt actttttttt cttcttgcct ttttttcttg    180

ttactttttt tctagttttt tttccttcca ctaagctttt tccttgattt atccttgggt    240

tcttctttct actcctttag attttttttt tatatattaa tttttaagtt tatgtatttt    300

ggtagattca attctctttc cctttccttt tccttcgctc cccttcctta tcaatgcttg    360

ctgtcagaag attaacaaga tacacattcc ttaaggcctc gtccccgccg ggtcacccgg    420

ccagcgacat ggaggcccag aataccctcc ttgacagtct tgacgtgcgc agctcagggg    480

catgatgtga ctgtcgcccg tacatttagc ccatacatcc ccatgtataa tcatttgcat    540

ccatacattt tgatggccgc acggcgcgaa gcaaaaatta cggctcctcg ctgcagacct    600

gcgagcaggg aaacgctccc ctcacagacg cgttgaattg tccccacgcc gcgcccctgt    660

agagaaatat aaaaggttag gatttgccac tgaggttctt ctttcatata cttcctttta    720

aaatcttgct aggatacagt tctcacatca catccgaaca taaacaacca tgtaaaatga    780

ccactcttga cgacacggct taccggtacc gcaccagtgt cccgggggac gccgaggcca    840

tcgaggcact ggatgggtcc ttcaccaccg acaccgtctt ccgcgtcacc gccaccgggg    900

acggcttcac cctgcgggag gtgccggtgg acccgcccct gaccaaggtg ttccccgacg    960

acgaatcgga cgacgaatcg gacgccgggg aggacggcga cccggactcc cggacgttcg   1020

tcgcgtacgg ggacgacggc gacctggcgg gcttcgtggt cgtctcgtac tccggctgga   1080

accgccggct gaccgtcgag gacatcgagg tcgccccgga gcaccggggg cacggggtcg   1140

ggcgcgcgtt gatggggctc gcgacggagt tcgcccgcga gcggggcgcc gggcacctct   1200

ggctggaggt caccaacgtc aacgcaccgg cgatccacgc gtaccggcgg atggggttca   1260

ccctctgcgg cctggacacc gccctgtacg acggcaccgc ctcggacggc gagcaggcgc   1320

tctacatgag catgccctgc ccctagtact gacaataaaa agattcttgt tttcaagaac   1380

ttgtcatttg tatagttttt ttatattgta gttgttctat tttaatcaaa tgttagcgtg   1440

atttatattt tttttcgcct cgacatcatc tgcccagatg cgaagttaag tgcgcagaaa   1500

gtaatatcat gcgtcaatcg tatgtgaatg ctggtcgcta tactgctgtc gattcgatac   1560

taacgccgcc atccagtgtc gacggatcct aggtgtacag ggcccaaaag ggcgaattct   1620

gcagatatcc atcacactgg cggccgctcg aggatagtct acaacaacgt ccgcatggaa   1680

gacctaccgg agatgattga agagctagac atcgatgacg aatagacact ctcccccccc   1740

ctccccctct gatctttcct gttgcctctt tttcccccaa ccaatttatc attatacaca   1800

agttctacaa ctactactag taacattact acagttatta taattttcta ttctcttttt   1860

ctttaagaat ctatcattaa cgttaatttc tatatataca taactaccat tatacacgct   1920

attatcgttt acatatcaca tcaccgttaa tgaaagatac gacaccctgt acactaacac   1980

aattaaataa tcgccataac cttttctgtt atctatagcc cttaaagctg tttcttcgag   2040

ctttttcact gcagatct                                                 2058


<210>  19
<211>  816
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  19
ccatatgatc atgtgtcgtc gcacacatat atatatgcct gtatgtgtca gcactaaagt     60

tgcctggcca tccacgctat atatacacgc ctggcggatc tgctcgagga ttgcctacgc    120

gtgggcttga tccaccaacc aacgctcgcc aaatgaactg gcgctttggt cttctgccat    180

cgtccgtaaa ccccggccaa agagaccgga aagatcggtg aaaacatctt gatcttgctc    240

ccgggaattt tagattcagg taggaaattg attacatcaa tactgttacc ctgaatcata    300

ttcgacgatg tcgtctcaca cggaaatata attcatttct tggttttcca aaaaaatttt    360

catttttttt cacttttttg tttcgtcctc cttttttttt tttttttttt attttttttc    420

ctgtgttcac cttttttttt ttcagttgac atctttctgc attcttttct gtgttttttt    480

tttttttttt cgtttttcca ttgttcgttc gttgcctgtt ttttcgccct attgttctcg    540

agcctaaaaa ttttttcctt tcctgctttc ctttcttcgt tcaaagtttc ctattccatt    600

gttctctttg gtaaactcat tgttgtcgga actcagatat attcaggtca atttactgta    660

cttcaattga cttttttctt gaaatttcaa cttgcctttt caacttgttc ttctttttta    720

atcttattct acactttagt tcccttacct tgttcctaat tattgtctag caaaaagaaa    780

acatacacct atttcattca cacactgcag aaaatg                              816


<210>  20
<211>  12350
<212>  DNA
<213>  Artificial

<220>
<223>  pRN500

<400>  20
tcgatgataa gctgtcaaag atgagaatta attccacgga ctatagacta tactagatac     60

tccgtctact gtacgataca cttccgctca ggtccttgtc ctttaacgag gccttaccac    120

tcttttgtta ctctattgat ccagctcagc aaaggcagtg tgatctaaga ttctatcttc    180

gcgatgtagt aaaactagct agaccgagaa agagactaga aatgcaaaag gcacttctac    240

aatggctgcc atcattatta tccgatgtga cgctgcagct tctcaatgat attcgaatac    300

gctttgagga gatacagcct aatatccgac aaactgtttt acagatttac gatcgtactt    360

gttacccatc attgaatttt gaacatccga acctgggagt tttccctgaa acagatagta    420

tatttgaacc tgtataataa tatatagtct agcgctttac ggaagacaat gtatgtattt    480

cggttcctgg agaaactatt gcatctattg cataggtaat cttgcacgtc gcatccccgg    540

ttcattttct gcgtttccat cttgcacttc aatagcatat ctttgttaac gaagcatctg    600

tgcttcattt tgtagaacaa aaatgcaacg cgagagcgct aatttttcaa acaaagaatc    660

tgagctgcat ttttacagaa cagaaatgca acgcgaaagc gctattttac caacgaagaa    720

tctgtgcttc atttttgtaa aacaaaaatg caacgcgacg agagcgctaa tttttcaaac    780

aaagaatctg agctgcattt ttacagaaca gaaatgcaac gcgagagcgc tattttacca    840

acaaagaatc tatacttctt ttttgttcta caaaaatgca tcccgagagc gctatttttc    900

taacaaagca tcttagatta ctttttttct cctttgtgcg ctctataatg cagtctcttg    960

ataacttttt gcactgtagg tccgttaagg ttagaagaag gctactttgg tgtctatttt   1020

ctcttccata aaaaaagcct gactccactt cccgcgttta ctgattacta gcgaagctgc   1080

gggtgcattt tttcaagata aaggcatccc cgattatatt ctataccgat gtggattgcg   1140

catactttgt gaacagaaag tgatagcgtt gatgattctt cattggtcag aaaattatga   1200

acggtttctt ctattttgtc tctatatact acgtatagga aatgtttaca ttttcgtatt   1260

gttttcgatt cactctatga atagttctta ctacaatttt tttgtctaaa gagtaatact   1320

agagataaac ataaaaaatg tagaggtcga gtttagatgc aagttcaagg agcgaaaggt   1380

ggatgggtag gttatatagg gatatagcac agagatatat agcaaagaga tacttttgag   1440

caatgtttgt ggaagcggta ttcgcaatgc cggctttccc cgtcaagctc taaatcgggg   1500

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta   1560

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt   1620

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat   1680

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa   1740

tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt ttacaatttc   1800

ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcag ggtaataact   1860

gatataatta aattgaagct ctaatttgtg agtttagtat acatgcattt acttataata   1920

cagtttttta gttttgctgg ccgcatcttc tcaaatatgc ttcccagcct gcttttctgt   1980

aacgttcacc ctctacctta gcatcccttc cctttgcaaa tagtcctctt ccaacaataa   2040

taatgtcaga tcctgtagag accacatcat ccacggttct atactgttga cccaatgcgt   2100

ctcccttgtc atctaaaccc acaccgggtg tcataatcaa ccaatcgtaa ccttcatctc   2160

ttccacccat gtctctttga gcaataaagc cgataacaaa atctttgtcg ctcttcgcaa   2220

tgtcaacagt acccttagta tattctccag tagataggga gcccttgcat gacaattctg   2280

ctaacatcaa aaggcctcta ggttcctttg ttacttcttc tgccgcctgc ttcaaaccgc   2340

taacaatacc tgggcccacc acaccgtgtg cattcgtaat gtctgcccat tctgctattc   2400

tgtatacacc cgcagagtac tgcaatttga ctgtattacc aatgtcagca aattttctgt   2460

cttcgaagag taaaaaattg tacttggcgg ataatgcctt tagcggctta actgtgccct   2520

ccatggaaaa atcagtcaag atatccacat gtgtttttag taaacaaatt ttgggaccta   2580

atgcttcaac taactccagt aattccttgg tggtacgaac atccaatgaa gcacacaagt   2640

ttgtttgctt ttcgtgcatg atattaaata gcttggcagc aacaggacta ggatgagtag   2700

cagcacgttc cttatatgta gctttcgaca tgatttatct tcgtttcctg caggtttttg   2760

ttctgtgcag ttgggttaag aatactgggc aatttcatgt ttcttcaaca ctacatatgc   2820

gtatatatac caatctaagt ctgtgctcct tccttcgttc ttccttctgt tcggagatta   2880

ccgaatcaaa aaaatttcaa agaaaccgaa atcaaaaaaa agaataaaaa aaaaatgatg   2940

aattgaattg aaaagcgtgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa   3000

gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg   3060

catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac   3120

cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta   3180

atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg   3240

gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat   3300

aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc   3360

gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa   3420

cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac   3480

tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga   3540

tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag   3600

agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca   3660

cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca   3720

tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa   3780

ccgctttttt tcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc   3840

tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa   3900

cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag   3960

actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct   4020

ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac   4080

tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggc agtcaggcaa   4140

ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt   4200

aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat   4260

ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg   4320

agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc   4380

ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg   4440

tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag   4500

cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact   4560

ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg   4620

gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc   4680

ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg   4740

aactgagata cctacagcgt gagcattgag aaagcgccac gcttcccgaa gggagaaagg   4800

cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag   4860

gggggaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc   4920

gatttttgtg atgctcgtca ggggggccga gcctatggaa aaacgccagc aacgcggcct   4980

ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc   5040

ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc   5100

gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac   5160

cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact   5220

ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta cctcactcat taggcacccc   5280

aggctttaca ctttatgctt ccggctccta tgttgtgtgg aattgtgagc ggataacaat   5340

ttcacacagg aaacagctat gaccatgatt acgccaagct cggaattaac cctcactaaa   5400

gggaacaaaa gctgggtacc gggccccccc tcgaccggtc ccacacacca tagcttcaaa   5460

atgtttctac tcctttttta ctcttccaga ttttctcgga ctccgcgcat cgccgtacca   5520

cttcaaaaca cccaagcaca gcatactaaa tttcccctct ttcttcctct agggtgtcgt   5580

taattacccg tactaaaggt ttggaaaaga aaaaagagac cgcctcgttt ctttttcttc   5640

gtcgaaaaag gcaataaaaa tttttatcac gtttcttttt cttgaaaatt tttttttttg   5700

atttttttct ctttcgatga cctcccattg atatttaagt taataaacgg tcttcaattt   5760

ctcaagtttc agtttcattt ttcttgttct attacaactt tttttacttc ttgctcatta   5820

gaaagaaagc atagcaatct aatctaagct gcagaagctt aaaatgtcgc cctctgccgt   5880

acaatcatca aaactagaag aacagtcaag tgaaattgac aagttgaaag caaaaatgtc   5940

ccagtctgcc gccactgcgc agcagaagaa ggaacatgag tatgaacatt tgacttcggt   6000

caagatcgtg ccacaacggc ccatctcaga tagactgcag cccgcaattg ctacccacta   6060

ttctccacac ttggacgggt tgcaggacta tcagcgcttg cacaaggagt ctattgaaga   6120

ccctgctaag ttcttcggtt ctaaagctac ccaattttta aactggtcta agccattcga   6180

taaggtgttc atcccagacc ctaaaacggg caggccctcc ttccagaaca atgcatggtt   6240

cctcaacggc caattaaacg cctgttacaa ctgtgttgac agacatgcct tgaagactcc   6300

taacaagaaa gccattattt tcgaaggtga cgagcctggc caaggctatt ccattaccta   6360

caaggaacta cttgaagaag tttgtcaagt ggcacaagtg ctgacttact ctatgggcgt   6420

tcgcaagggc gatactgttg ccgtgtacat gcctatggtc ccagaagcaa tcataacctt   6480

gttggccatt tcccgtatcg gtgccattca ctccgtagtc tttgccgggt tttcttccaa   6540

ctccttgaga gatcgtatca acgatgggga ctctaaagtt gtcatcacta cagatgaatc   6600

caacagaggt ggtaaagtca ttgagactaa aagaattgtt gatgacgcgc taagagagac   6660

cccaggcgtg agacacgtct tggtttatag aaagaccaac aatccatctg ttgctttcca   6720

tgcccccaga gatttggatt gggcaacaga aaagaagaaa tacaagacct actatccatg   6780

cacacccgtt gattctgagg atccattatt cttgttgtat acgtctggtt ctactggtgc   6840

ccccaagggt gttcaacatt ctaccgcagg ttacttgctg ggagctttgt tgaccatgcg   6900

ctacactttt gacactcacc aagaagacgt tttcttcaca gctggagaca ttggctggat   6960

tacaggccac acttatgtgg tttatggtcc cttactatat ggttgtgcca ctttggtctt   7020

tgaagggact cctgcgtacc caaattactc ccgttattgg gatattattg atgaacacaa   7080

agtcacccaa ttttatgttg cgccaactgc tttgcgtttg ttgaaaagag ctggtgattc   7140

ctacatcgaa aatcattcct taaaatcttt gcgttgcttg ggttcggtcg gtgagccaat   7200

tgctgctgaa gtttgggagt ggtactctga aaaaataggt aaaaatgaaa tccccattgt   7260

agacacctac tggcaaacag aatctggttc gcatctggtc accccgctgg ctggtggtgt   7320

tacaccaatg aaaccgggtt ctgcctcatt ccccttcttc ggtattgatg cagttgttct   7380

tgaccctaac actggtgaag aacttaacac cagccacgca gagggtgtcc ttgccgtcaa   7440

agctgcatgg ccatcatttg caagaactat ttggaaaaat catgataggt atctagacac   7500

ttatttgaac ccttaccctg gctactattt cactggtgat ggtgctgcaa aggataagga   7560

tggttatatc tggattttgg gtcgtgtaga cgatgtggtg aacgtctctg gtcaccgtct   7620

gtctaccgct gaaattgagg ctgctattat cgaagatcca attgtggccg agtgtgctgt   7680

tgtcggattc aacgatgact tgactggtca agcagttgct gcatttgtgg tgttgaaaaa   7740

caaatctagt tggtccaccg caacagatga tgaattacaa gatatcaaga agcatttggt   7800

ctttactgtt agaaaagaca tcgggccatt tgccgcacca aaattgatca ttttagtgga   7860

tgacttgccc aagacaagat ccggcaaaat tatgagacgt attttaagaa aaatcctagc   7920

aggagaaagt gaccaactag gcgacgtttc tacattgtca aaccctggca ttgttagaca   7980

tctaattgat tcggtcaagt tgtaacttaa gcgcgcgaat ttcttatgat ttatgatttt   8040

tattattaaa taagttataa aaaaaataag tgtatacaaa ttttaaagtg actcttaggt   8100

tttaaaacga aaattcttat tcttgagtaa ctctttcctg taggtcaggt tgctttctca   8160

ggtatagcat gaggtcgctc ttattgacca cacctctacc ggcatgccga gcaaatgcct   8220

gcaaatcgct ccccatttca cccaattgta gatatgctaa ctccagcaat gagttgatga   8280

atctcggtgt gtattttatg tcctcagagg acaacacctg ttgtaatcgt tcttccacac   8340

gtacgtttta aacagttgat gagaaccttt ttcgcaagtt caaggtgctc taatttttaa   8400

aatttttact tttcgcgaca caataaagtc ttcacgacgc taaactatta gtgcacataa   8460

tgtagttact tggacgctgt tcaataatgt ataaaattta tttcctttgc attacgtaca   8520

ttatataacc aaatcttaaa aatatagaaa tatgatatgt gtataataat ataagcaaaa   8580

tttacgtatc tttgcttata atatagcttt aatgttcttt aggtatatat ttaagagcga   8640

tttgtctcga cttatttctt tttttgagag aaaaattggt tctctacagc agaaatgatg   8700

gcaggtacaa cttctgggtt ggccaaagta gttaggtcac ctagctgttc ggcttcgtta   8760

gaagcaacct ttcttagaac tcttctcata atctttcctg accttgttct tggtagatct   8820

ctaactagaa taatggtttt tggtgaggcg aaaggaccaa tctcacccct aacttgtaag   8880

atcaattctc tacgtaaatt atctggtgtg atgtgttctg catcaccttc agtagcgttg   8940

ttttgtagat aaccatcttt tagggaaaca tatgcaacga cggtttgacc ggtcaattca   9000

tctggaatac cgacaacagc agcttccgag acgttttcgt gatttgagat agatgcttca   9060

atttctgatg tggataatct atgaccggaa acatttacaa cgtcgtcaac tctacccctg   9120

atccagtagt aaccatcatg atctctacca gcaccatcac ctgtgaaata gtgaccagga   9180

taaggtttca agtaagtatc catgtaacgg tcgtggtggt tccaaacaga tctagccatt   9240

gatggccatg gtgatttaac ggcaaggaca ccttcgacat cattaccttc taattccaca   9300

cctgtaacag ggtcaatgat acaagcgtta ataccaaaga atggcacggt agcagaacca   9360

ggttttgttg ggacagcacc tgccaaagga gcaattaaat gagaaccaga ctctgtttgc   9420

cacatagtgt cacaaatgac acagtttttg ttacccactt tttcatgata ccattcccat   9480

aagtctggag agattggttc accgacggaa cccaagacac gtaatgagga agtgtcatat   9540

ttggcaattt cggcttcacc tacacgtttg attaatctta aagcagttgg agccacatag   9600

aaatgggtag ccttgtgacg ttggataatt ctccaatatc taccataatc tgggtaggca   9660

ggagtggatt cgaaaattat tgaggcggta cccaaggtta atggaccata tagagcatag   9720

gtgtgacccg tgatccagcc gacgtcaccg gcagtgaaga gaacatcttc tgggtgaata   9780

tcaaaaacgt atctagttgt taaagcggca cctaataaat aaccacctgt agtgtgaacg   9840

acaccctttg gagaaccagt ggaaccggaa gtgtataata aaaatagagg atcttcagcg   9900

tcacatgaaa caggaggtag gtaagttctc tgcttagcgg cctcctcatg ccaccagtaa   9960

tctctaccgg ccttcattgg aataccttca gtaccagttc tttggaaaac caagatacgg  10020

gaaaccaaat cgactccgtt caaaccttcg tcaacaattt ttttagtgtt gatggtctta  10080

ccacctcttt taccttcatc acaagtgatg accactttag aattagcgtc aacgacacga  10140

tctttcaacg aaccagcgga gaacccagca aagacaacag agtgaatagc accaatacga  10200

gccacagcca acatagcaat gaccgcttct ggaatcattg gcaaatagat agccactgtg  10260

tcacctttct taacgcccca gctttttaag acaccagcga tttgggaaac ttttctgagt  10320

aattcaccaa atgtgatgat tttgttgtcg gattcgtcat cagcttcata gatcaaagct  10380

ggcttgtcgg gattagcaaa ggcatgtctg tcaacacaat tgtatgatgc attcaattta  10440

ccgttcaaaa accatgcaac atcaccattg ttcaatgaac cagattgaac tttggtgtat  10500

ggagcatccc aatgcaagta ttccttagcc atcttatcaa agaatttttc tggctcattg  10560

atagattgtt gatacatttc ttgataatgt tgcatatcag taacgtaacc cttgccgggt  10620

tggctgttgt aaaaatgttg aggagcctta agagccttta cgttgtgagc ttcataaact  10680

actttatgtt ccttgattgt cattttctgc agtctagata tatttgttgt aaaaagtaga  10740

taattacttc cttgatgatc tgtaaaaaag agaaaaagaa agcatctaag aacttgaaaa  10800

actacgaatt agaaaagacc aaatatgtat ttcttgcatt gaccaattta tgcaagttta  10860

tatatatgta aatgtaagtt tcacgaggtt ctactaaact aaaccacccc cttggttaga  10920

agaaaagagt gtgtgagaac aggctgttgt tgtcacacga ttcggacaat tctgtttgaa  10980

agagagagag taacagtacg atcgaacgaa ctttgctctg gagatcacag tgggcatcat  11040

agcatgtggt actaaaccct ttcccgccat tccagaacct tcgattgctt gttacaaaac  11100

ctgtgagccg tcgctaggac cttgttgtgt gacgaaattg gaagctgcaa tcaataggaa  11160

gacaggaagt cgagcgtgtc tgggtttttt cagttttgtt ctttttgcaa acaaatcacg  11220

agcgacggta atttctttct cgataagagg ccacgtgctt tatgagggta acatcaattc  11280

aagaaggagg gaaacacttc ctttttctgg ccctgataat agtatgaggg tgaagccaaa  11340

ataaaggatt cgcgcccaaa tcggcatctt taaatgcagg tatgcgatag ttcctcactc  11400

tttccttact cacgagtaat tcttgcaaat gcctattatg cagatgttat aatatctgtg  11460

cgtcttgagt tgaagagctc gagactagat gcatgctcga gcggccgcca gtgtgatgga  11520

tatctgcaga attcgccctt ttgggccctg tacacctagg atccgtcgac actggatggc  11580

ggcgttagta tcgaatcgac agcagtatag cgaccagcat tcacatacga ttgacgcatg  11640

atattacttt ctgcgcactt aacttcgcat ctgggcagat gatgtcgagg cgaaaaaaaa  11700

tataaatcac gctaacattt gattaaaata gaacaactac aatataaaaa aactatacaa  11760

atgacaagtt cttgaaaaca agaatctttt tattgtcagt actgattaga aaaactcatc  11820

gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat atttttgaaa  11880

aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga tggcaagatc  11940

ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta atttcccctc  12000

gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat ccggtgagaa  12060

tggcaaaagc ttatgcattt ctttccagac ttgttcaaca ggccagccat tacgctcgtc  12120

atcaaaatca ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct gagcgagacg  12180

aaatacgcga tcgctgttaa aaggacaatt acaaacagga atcgaatgca accggcgcag  12240

gaacactgcc agcgcatcaa caatattttc acctgaatca ggatattctt ctaatacctg  12300

gaatgctgtt ttgccgggga tcgcagtggt gagtaaccat gcatcatcag             12350


<210>  21
<211>  1120
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide seqeunce encoding E.coli gldA codon-optimised for 
       yeast

<400>  21
ctgcagaaaa tggacagaat catccaatct ccaggtaagt acatccaagg tgctgacgtt     60

atcaacagat tgggtgaata cttgaagcca ttggctgaaa gatggttggt tgttggtgac    120

aagttcgttt tgggtttcgc tcaatctacc gttgaaaagt ctttcaagga cgctggtttg    180

gttgttgaaa tcgctccatt cggtggtgaa tgttctcaaa acgaaatcga cagattgaga    240

ggtatcgctg aaaccgctca atgtggtgct atcttgggta tcggtggtgg taagaccttg    300

gacaccgcta aggctttggc tcacttcatg ggtgttccag ttgctatcgc tccaaccatc    360

gcttctaccg acgctccatg ttctgctttg tctgttatct acaccgacga aggtgaattc    420

gacagatact tgttgttgcc aaacaaccca aacatggtta tcgttgacac caagatcgtt    480

gctggtgctc cagctagatt gttggcagct ggtatcggtg acgctttggc tacctggttc    540

gaagctagag cttgttctag atctggtgct accaccatgg ctggtggtaa gtgtacccaa    600

gctgctttgg ctttggctga attgtgttac aacaccttgt tggaagaagg tgaaaaggct    660

atgttggctg ctgaacaaca cgttgttacc ccagctttgg aaagagttat cgaagctaac    720

acctacttgt ctggtgttgg tttcgaatct ggtggtttgg ctgctgctca cgctgttcac    780

aacggtttga ccgctatccc agacgctcac cactactacc acggtgaaaa ggttgctttc    840

ggtaccttga cccaattggt tttggaaaac gctccagttg aagaaatcga aaccgttgct    900

gctttgtctc acgctgttgg tttgccaatc accttggctc aattggacat caaggaagac    960

gttccagcta agatgagaat cgttgctgaa gctgcttgtg ctgaaggtga aaccatccac   1020

aacatgccag gtggtgctac cccagaccaa gtttacgctg ctttgttggt tgctgaccaa   1080

tacggtcaaa gattcctaca agaatgggaa taaggcgcgc                         1120


<210>  22
<211>  1450
<212>  DNA
<213>  Artificial

<220>
<223>  DAK1 PCR fragment

<400>  22
tctagaaaat gtccgctaaa tcgtttgaag tcacagatcc agtcaattca agtctcaaag     60

ggtttgccct tgctaacccc tccattacgc tggtccctga agaaaaaatt ctcttcagaa    120

agaccgattc cgacaagatc gcattaattt ctggtggtgg tagtggacat gaacctacac    180

acgccggttt cattggtaag ggtatgttga gtggcgccgt ggttggcgaa atttttgcat    240

ccccttcaac aaaacagatt ttaaatgcaa tccgtttagt caatgaaaat gcgtctggcg    300

ttttattgat tgtgaagaac tacacaggtg atgttttgca ttttggtctg tccgctgaga    360

gagcaagagc cttgggtatt aactgccgcg ttgctgtcat aggtgatgat gttgcagttg    420

gcagagaaaa gggtggtatg gttggtagaa gagcattggc aggtaccgtt ttggttcata    480

agattgtagg tgccttcgca gaagaatatt ctagtaagta tggcttagac ggtacagcta    540

aagtggctaa aattatcaac gacaatttgg tgaccattgg atcttcttta gaccattgta    600

aagttcctgg caggaaattc gaaagtgaat taaacgaaaa acaaatggaa ttgggtatgg    660

gtattcataa cgaacctggt gtgaaagttt tagaccctat tccttctacc gaagacttga    720

tctccaagta tatgctacca aaactattgg atccaaacga taaggataga gcttttgtaa    780

agtttgatga agatgatgaa gttgtcttgt tagttaacaa tctcggcggt gtttctaatt    840

ttgttattag ttctatcact tccaaaacta cggatttctt aaaggaaaat tacaacataa    900

ccccggttca aacaattgct ggcacattga tgacctcctt caatggtaat gggttcagta    960

tcacattact aaacgccact aaggctacaa aggctttgca atctgatttt gaggagatca   1020

aatcagtact agacttgttg aacgcattta cgaacgcacc gggctggcca attgcagatt   1080

ttgaaaagac ttctgcccca tctgttaacg atgacttgtt acataatgaa gtaacagcaa   1140

aggccgtcgg tacctatgac tttgacaagt ttgctgagtg gatgaagagt ggtgctgaac   1200

aagttatcaa gagcgaaccg cacattacgg aactagacaa tcaagttggt gatggtgatt   1260

gtggttacac tttagtggca ggagttaaag gcatcaccga aaaccttgac aagctgtcga   1320

aggactcatt atctcaggcg gttgcccaaa tttcagattt cattgaaggc tcaatgggag   1380

gtacttctgg tggtttatat tctattcttt tgtcgggttt ttcacacgga ttaattcagg   1440

tttgtaaatc                                                          1450


<210>  23
<211>  1698
<212>  DNA
<213>  Artificial

<220>
<223>  GUP1 PCR fragment

<400>  23
gaattcaaaa tgtcgctgat cagcatcctg tctcccctaa ttacttccga gggcttagat     60

tcaagaatca aaccttcacc aaaaaaggat gcctctacta ccactaagcc atcactatgg    120

aaaactactg agttcaaatt ctactacatt gcatttctgg tcgtggttcc cttgatgttc    180

tatgctgggt tacaagctag ttcgcccgaa aatccaaact atgcaagata cgaacgtctc    240

ctatctcaag gttggttatt tggcagaaaa gtagacaata gtgattctca atataggttt    300

ttcagggaca attttgcgct attgtcagtt ttaatgctag tccacacttc tataaaacgc    360

attgtacttt attcaacaaa tatcactaaa ttgaggtttg atctgatatt tggtttgatc    420

tttttagtgg ccgctcatgg tgtcaattcg ataagaattt tagcccatat gctaatttta    480

tatgccatcg cccatgtact aaagaacttt agaagaatag ccaccatcag catttggatt    540

tatggtattt ctacgctttt tattaacgac aacttcagag catatccatt tggtaatatt    600

tgctcttttt taagcccatt ggaccattgg tatagaggta tcattccaag atgggatgtc    660

tttttcaatt ttactctttt gagagtctta agttacaact tggacttctt agagaggtgg    720

gagaatttac aaaagaagaa aagtccatcc tatgaatcaa aagaagctaa atcagccatt    780

ttgctcaatg aacgtgctag attaactgct gcacacccca tacaggacta cagcttaatg    840

aattatattg catatgttac ttacacgcca cttttcattg ccggccccat tataacattc    900

aatgattatg tttaccaatc gaaacatacc ttgccatcaa taaatttcaa attcattttt    960

tactatgcgg tgagattcgt tattgctctc ttatctatgg agttcatttt acactttctc   1020

cacgttgtgg caatctcaaa aaccaaagcg tgggaaaatg acacaccttt ccagatttcc   1080

atgattggct tatttaattt gaatattatt tggctaaaac tactgattcc gtggaggctg   1140

tttaggctgt gggctttgct agacggaatc gatacacctg aaaatatgat caggtgtgtt   1200

gataacaatt acagttcact agcattctgg agagcttggc atagaagcta caataagtgg   1260

gttgtccgtt acatatatat tcctctaggt ggttcaaaaa atagagtttt gacatcacta   1320

gcagtctttt ccttcgtagc tatatggcat gacatcgaac taaagttatt attatggggt   1380

tggctaatag ttttgttcct cttaccagaa atttttgcta cccaaatttt ctctcattat   1440

accgacgcag tctggtacag acacgtttgc gctgtcggtg ctgttttcaa catatgggtt   1500

atgatgatcg ctaatctttt tggattctgc ttgggctctg acggtactaa aaaattacta   1560

agcgatatgt tctgtaccgt atctggtttc aaatttgtaa ttttggcaag cgttagttta   1620

ttcatcgcag tacaaataat gtttgaaatc agagaagaag aaaagaggca cggaatttac   1680

ctaaaatgct gaggatcc                                                 1698


<210>  24
<211>  3037
<212>  DNA
<213>  Artificial

<220>
<223>  FPS1 PCR fragment

<400>  24
aagagctccg gactagtcgt acgaattcta tccttttgtt gtttccgggt gtacaatatg     60

gacttcctct tttctggcaa ccaaacccat acatcgggat tcctataata ccttcgttgg    120

tctccctaac atgtaggtgg cggaggggag atatacaata gaacagatac cagacaagac    180

ataatgggct aaacaagact acaccaatta cactgcctca ttgatggtgg tacataacga    240

actaatactg tagccctaga cttgatagcc atcatcatat cgaagtttca ctaccctttt    300

tccatttgcc atctattgaa gtaataatag gcgcatgcaa cttcttttct ttttttttct    360

tttctctctc ccccgttgtt gtctcaccat atccgcaatg acaaaaaaat gatggaagac    420

actaaaggaa aaaattaacg acaaagacag caccaacaga tgtcgttgtt ccagagctga    480

tgaggggtat ctcgaagcac acgaaacttt ttccttcctt cattcacgca cactactctc    540

taatgagcaa cggtatacgg ccttccttcc agttacttga atttgaaata aaaaaagttt    600

gctgtcttgc tatcaagtat aaatagacct gcaattatta atcttttgtt tcctcgtcat    660

tgttctcgtt ccctttcttc cttgtttctt tttctgcaca atatttcaag ctataccaag    720

catacaatca actccagctg cattaaaatg agtaatcctc aaaaagctct aaacgacttt    780

ctgtccagtg aatctgttca tacacatgat agttctagga aacaatctaa taagcagtca    840

tccgacgaag gacgctcttc atcacaacct tcacatcatc actctggtgg tactaacaac    900

aataataaca ataataataa taataataac agtaacaaca acaacaacgg caacgatggg    960

ggaaatgatg acgactatga ttatgaaatg caagattata gaccttctcc gcaaagtgcg   1020

cggcctactc ccacgtatgt tccacaatat tctgtagaaa gtgggactgc tttcccgatt   1080

caagaggtta ttcctagcgc atacattaac acacaagata taaaccataa agataacggt   1140

ccgccgagtg caagcagtaa tagagcattc aggcctagag ggcagaccac agtgtcggcc   1200

aacgtgctta acattgaaga tttttacaaa aatgcagacg atgcgcatac catcccggag   1260

tcacatttat cgagaaggag aagtaggtcg agggctacga gtaatgctgg gcacagtgcc   1320

aatacaggcg ccacgaatgg caggactact ggtgcccaaa ctaatatgga aagcaatgaa   1380

tcaccacgta acgtccccat tatggtgaag ccaaagacat tataccagaa ccctcaaaca   1440

cctacagtct tgccctccac ataccatcca attaataaat ggtcttccgt caaaaacact   1500

tatttgaagg aatttttagc cgagtttatg ggaacaatgg ttatgattat tttcggtagt   1560

gctgttgttt gtcaggtcaa tgttgctggg aaaatacagc aggacaattt caacgtggct   1620

ttggataacc ttaacgttac cgggtcttct gcagaaacga tagacgctat gaagagttta   1680

acatccttgg tttcatccgt tgcgggcggt acctttgatg atgtggcatt gggctgggct   1740

gctgccgtgg tgatgggcta tttctgcgct ggtggtagtg ccatctcagg tgctcatttg   1800

aatccgtcta ttacattagc caatttggtg tatagaggtt ttcccctgaa gaaagttcct   1860

tattactttg ctggacaatt gatcggtgcc ttcacaggcg ctttgatctt gtttatttgg   1920

tacaaaaggg tgttacaaga ggcatatagc gattggtgga tgaatgaaag tgttgcggga   1980

atgttttgcg tttttccaaa gccttatcta agttcaggac ggcaattttt ttccgaattt   2040

ttatgtggag ctatgttaca agcaggaaca tttgcgctga ccgatcctta tacgtgtttg   2100

tcctctgatg ttttcccatt gatgatgttt attttgattt tcattatcaa tgcttccatg   2160

gcttatcaga caggtacagc aatgaatttg gctcgtgatc tgggcccacg tcttgcacta   2220

tatgcagttg gatttgatca taaaatgctt tgggtgcatc atcatcattt cttttgggtt   2280

cccatggtag gcccatttat tggtgcgtta atgggggggt tggtttacga tgtctgtatt   2340

tatcagggtc atgaatctcc agtcaactgg tctttaccag tttataagga aatgattatg   2400

agagcctggt ttagaaggcc tggttggaag aagagaaata gagcaagaag aacatcggac   2460

ctgagtgact tctcatacaa taacgatgat gatgaggaat ttggagaaag aatggctctt   2520

caaaagacaa agaccaagtc atctatttca gacaacgaaa atgaagcagg agaaaagaaa   2580

gtgcaattta aatctgttca gcgcggcaaa agaacgtttg gtggtatacc aacaattctt   2640

gaagaagaag attccattga aactgcttcg ctaggtgcga cgacgactga ttctattggg   2700

ttatccgaca catcatcaga agattcgcat tatggtaatg ctaagaaggt aacatgagga   2760

tccccttttc ctttgtcgat atcatgtaat tagttatgtc acgcttacat tcacgccctc   2820

ctcccacatc cgctctaacc gaaaaggaag gagttagaca acctgaagtc taggtcccta   2880

tttatttttt ttaatagtta tgttagtatt aagaacgtta tttatatttc aaatttttct   2940

tttttttctg tacaaacgcg tgtacgcatg taacattata ctgaaaacct tgcttgagaa   3000

ggttttggga cgctcgaagg cttcctaggc tcgagtt                            3037


<210>  25
<211>  552
<212>  PRT
<213>  Citrobacter freundii

<400>  25

Met Ser Gln Phe Phe Phe Asn Gln Arg Thr His Leu Val Ser Asp Val 
1               5                   10                  15      


Ile Asp Gly Thr Ile Ile Ala Ser Pro Trp Asn Asn Leu Ala Arg Leu 
            20                  25                  30          


Glu Ser Asp Pro Ala Ile Arg Ile Val Val Arg Arg Asp Leu Asn Lys 
        35                  40                  45              


Asn Asn Val Ala Val Ile Ser Gly Gly Gly Ser Gly His Glu Pro Ala 
    50                  55                  60                  


His Val Gly Phe Ile Gly Lys Gly Met Leu Thr Ala Ala Val Cys Gly 
65                  70                  75                  80  


Asp Val Phe Ala Ser Pro Ser Val Asp Ala Val Leu Thr Ala Ile Gln 
                85                  90                  95      


Ala Val Thr Gly Glu Ala Gly Cys Leu Leu Ile Val Lys Asn Tyr Thr 
            100                 105                 110         


Gly Asp Arg Leu Asn Phe Gly Leu Ala Ala Glu Lys Ala Arg Arg Leu 
        115                 120                 125             


Gly Tyr Asn Val Glu Met Leu Ile Val Gly Asp Asp Ile Ser Leu Pro 
    130                 135                 140                 


Asp Asn Lys His Pro Arg Gly Ile Ala Gly Thr Ile Leu Val His Lys 
145                 150                 155                 160 


Ile Ala Gly Tyr Phe Ala Glu Arg Gly Tyr Asn Leu Ala Thr Val Leu 
                165                 170                 175     


Arg Glu Ala Gln Tyr Ala Ala Asn Asn Thr Phe Ser Leu Gly Val Ala 
            180                 185                 190         


Leu Ser Ser Cys His Leu Pro Gln Glu Ala Asp Ala Ala Pro Arg His 
        195                 200                 205             


His Pro Gly His Ala Glu Leu Gly Met Gly Ile His Gly Glu Pro Gly 
    210                 215                 220                 


Ala Ser Val Ile Asp Thr Gln Asn Ser Ala Gln Val Val Asn Leu Met 
225                 230                 235                 240 


Val Asp Lys Leu Met Ala Ala Leu Pro Glu Thr Gly Arg Leu Ala Val 
                245                 250                 255     


Met Ile Asn Asn Leu Gly Gly Val Ser Val Ala Glu Met Ala Ile Ile 
            260                 265                 270         


Thr Arg Glu Leu Ala Ser Ser Pro Leu His Pro Arg Ile Asp Trp Leu 
        275                 280                 285             


Ile Gly Pro Ala Ser Leu Val Thr Ala Leu Asp Met Lys Ser Phe Ser 
    290                 295                 300                 


Leu Thr Ala Ile Val Leu Glu Glu Ser Ile Glu Lys Ala Leu Leu Thr 
305                 310                 315                 320 


Glu Val Glu Thr Ser Asn Trp Pro Thr Pro Val Pro Pro Arg Glu Ile 
                325                 330                 335     


Ser Cys Val Pro Ser Ser Gln Arg Ser Ala Arg Val Glu Phe Gln Pro 
            340                 345                 350         


Ser Ala Asn Ala Met Val Ala Gly Ile Val Glu Leu Val Thr Thr Thr 
        355                 360                 365             


Leu Ser Asp Leu Glu Thr His Leu Asn Ala Leu Asp Ala Lys Val Gly 
    370                 375                 380                 


Asp Gly Asp Thr Gly Ser Thr Phe Ala Ala Gly Ala Arg Glu Ile Ala 
385                 390                 395                 400 


Ser Leu Leu His Arg Gln Gln Leu Pro Leu Asp Asn Leu Ala Thr Leu 
                405                 410                 415     


Phe Ala Leu Ile Gly Glu Arg Leu Thr Val Val Met Gly Gly Ser Ser 
            420                 425                 430         


Gly Val Leu Met Ser Ile Phe Phe Thr Ala Ala Gly Gln Lys Leu Glu 
        435                 440                 445             


Gln Gly Ala Ser Val Ala Glu Ser Leu Asn Thr Gly Leu Ala Gln Met 
    450                 455                 460                 


Lys Phe Tyr Gly Gly Ala Asp Glu Gly Asp Arg Thr Met Ile Asp Ala 
465                 470                 475                 480 


Leu Gln Pro Ala Leu Thr Ser Leu Leu Thr Gln Pro Gln Asn Leu Gln 
                485                 490                 495     


Ala Ala Phe Asp Ala Ala Gln Ala Gly Ala Glu Arg Thr Cys Leu Ser 
            500                 505                 510         


Ser Lys Ala Asn Ala Gly Arg Ala Ser Tyr Leu Ser Ser Glu Ser Leu 
        515                 520                 525             


Leu Gly Asn Met Asp Pro Gly Ala His Ala Val Ala Met Val Phe Lys 
    530                 535                 540                 


Ala Leu Ala Glu Ser Glu Leu Gly 
545                 550         


<210>  26
<211>  1678
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide sequence encoding the C. freundii dhaK codon-optimised
       for yeast

<400>  26
tctagaaaaa tgtctcaatt cttcttcaac cagagaaccc acttggtttc tgacgttatc     60

gacggtgcta tcatcgcttc accatggaac aatttggcta gattggaatc tgacccagct    120

atcagaatcg ttgttagaag agacttgaac aagaacaacg ttgctgttat ctctggtggt    180

ggttctggtc acgaaccagc tcacgttggt ttcatcggta agggtatgtt gaccgctgct    240

gtttgtggtg acgttttcgc ttctccatct gttgacgctg ttttgactgc tatccaagct    300

gttaccggtg aagctggttg tttgttgatc gttaagaact acaccggtga cagattgaac    360

ttcggtttgg ctgctgaaaa ggctagaaga ttgggttaca acgttgaaat gttgatcgtt    420

ggtgacgaca tctctttgcc agacaacaag cacccaagag gtatcgctgg taccatcttg    480

gttcacaaga tcgctggtta cttcgctgaa agaggttaca acttagctac cgttttgaga    540

gaagctcaat acgctgcttc taacaccttc tctttgggtg ttgctttgtc ttcttgtcac    600

ttgccacaag aaaccgacgc tgctccaaga caccacccag gtcacgctga attgggtatg    660

ggtatccacg gtgaaccagg tgcttctgtt atcgacaccc aaaactctgc tcaagttgtt    720

aacttgatgg ttgacaagtt gttggctgct ttgccagaaa ccggtagatt ggctgttatg    780

atcaacaact tgggtggtgt ttctgttgct gaaatggcta tcatcaccag agaattggct    840

tcttctccat tgcactcaag aatcgactgg ttgatcggtc cagcttcttt ggtaaccgct    900

ttggacatga agggtttctc tttgaccgct atcgttttgg aagaatctat cgaaaaggct    960

ttgttgaccg aagttgaaac ctctaactgg ccaaccccag ttccaccaag agaaatcacc   1020

tgtgttgttt cttctcacgc ttctgctaga gttgaattcc aaccatctgc taacgctttg   1080

gttgctggta tcgttgaatt ggttaccgct accttgtctg acttggaaac ccacttgaac   1140

gctttggacg ctaaggttgg tgacggtgac accggttcta ccttcgctgc tgctgctaga   1200

gaaatcgctt ctttgttgca cagacaacaa ttgccattga acaacttggc taccttgttc   1260

gctttgatcg gtgaaagatt gaccgttgtt atgggtggtt cttctggtgt tttgatgtct   1320

atcttcttca ccgctgctgg tcaaaagttg gaacaaggtg ctaacgttgt tgaagctttg   1380

aacaccggtt tggctcaaat gaagttctac ggtggtgctg acgaaggtga cagaaccatg   1440

atcgacgctt tgcaaccagc tttgacctct ttgttggctc aaccaaagaa cttgcaagct   1500

gctttcgacg ctgctcaagc tggtgctgaa agaacctgtt tgtcttctaa ggctaacgct   1560

ggtagagctt cttacttgtc ttctgaatct ttgttgggta acatggaccc aggtgctcaa   1620

agattggcta tggttttcaa ggctttggct gaatctgaat tgggttaata aggtcgac     1678


<210>  27
<211>  2951
<212>  DNA
<213>  Artificial

<220>
<223>  pRNdhaK

<400>  27
ggatccacta gtaacggccg ccagtgtgct ggaattcgcc cttctcgagc ttaagacgcg     60

tttcttcttc agattccctc atggagaaag tgcggcagat gtatatgaca gagtcgccag    120

tttccaagag actttattca ggcacttcca tgataggcaa gagagaagac ccagagatgt    180

tgttgtccta gttacacatg gtatttattc cagagtattc ctgatgaaat ggtttagatg    240

gacatacgaa gagtttgaat cgtttaccaa tgttcctaac gggagcgtaa tggtgatgga    300

actggacgaa tccatcaata gatacgtcct gaggaccgtg ctacccaaat ggactgattg    360

tgagggagac ctaactacat agtgtttaaa gattacggat atttaactta cttagaataa    420

tgccattttt ttgagttata ataatcctac gttagtgtga gcgggattta aactgtgagg    480

accttaatac attcagacac ttctgcggta tcaccctact tattcccttc gagattatat    540

ctaggaaccc atcaggttgg tggaagatta cccgttctaa gacttttcag cttcctctat    600

tgatgttaca cctggacacc ccttttctgg catccagttt ttaatcttca gtggcatgtg    660

agattctccg aaattaatta aagcaatcac acaattctct cggataccac ctcggttgaa    720

actgacaggt ggtttgttac gcatgctaat gcaaaggagc ctatatacct ttggctcggc    780

tgctgtaaca gggaatataa agggcagcat aatttaggag tttagtgaac ttgcaacatt    840

tactattttc ccttcttacg taaatatttt tctttttaat tctaaatcaa tctttttcaa    900

ttttttgttt gtattctttt cttgcttaaa tctataacta caaaaaacac atacataaat    960

ctagaaaaat gtctcaattc ttcttcaacc agagaaccca cttggtttct gacgttatcg   1020

acggtgctat catcgcttca ccatggaaca atttggctag attggaatct gacccagcta   1080

tcagaatcgt tgttagaaga gacttgaaca agaacaacgt tgctgttatc tctggtggtg   1140

gttctggtca cgaaccagct cacgttggtt tcatcggtaa gggtatgttg accgctgctg   1200

tttgtggtga cgttttcgct tctccatctg ttgacgctgt tttgactgct atccaagctg   1260

ttaccggtga agctggttgt ttgttgatcg ttaagaacta caccggtgac agattgaact   1320

tcggtttggc tgctgaaaag gctagaagat tgggttacaa cgttgaaatg ttgatcgttg   1380

gtgacgacat ctctttgcca gacaacaagc acccaagagg tatcgctggt accatcttgg   1440

ttcacaagat cgctggttac ttcgctgaaa gaggttacaa cttagctacc gttttgagag   1500

aagctcaata cgctgcttct aacaccttct ctttgggtgt tgctttgtct tcttgtcact   1560

tgccacaaga aaccgacgct gctccaagac accacccagg tcacgctgaa ttgggtatgg   1620

gtatccacgg tgaaccaggt gcttctgtta tcgacaccca aaactctgct caagttgtta   1680

acttgatggt tgacaagttg ttggctgctt tgccagaaac cggtagattg gctgttatga   1740

tcaacaactt gggtggtgtt tctgttgctg aaatggctat catcaccaga gaattggctt   1800

cttctccatt gcactcaaga atcgactggt tgatcggtcc agcttctttg gtaaccgctt   1860

tggacatgaa gggtttctct ttgaccgcta tcgttttgga agaatctatc gaaaaggctt   1920

tgttgaccga agttgaaacc tctaactggc caaccccagt tccaccaaga gaaatcacct   1980

gtgttgtttc ttctcacgct tctgctagag ttgaattcca accatctgct aacgctttgg   2040

ttgctggtat cgttgaattg gttaccgcta ccttgtctga cttggaaacc cacttgaacg   2100

ctttggacgc taaggttggt gacggtgaca ccggttctac cttcgctgct gctgctagag   2160

aaatcgcttc tttgttgcac agacaacaat tgccattgaa caacttggct accttgttcg   2220

ctttgatcgg tgaaagattg accgttgtta tgggtggttc ttctggtgtt ttgatgtcta   2280

tcttcttcac cgctgctggt caaaagttgg aacaaggtgc taacgttgtt gaagctttga   2340

acaccggttt ggctcaaatg aagttctacg gtggtgctga cgaaggtgac agaaccatga   2400

tcgacgcttt gcaaccagct ttgacctctt tgttggctca accaaagaac ttgcaagctg   2460

ctttcgacgc tgctcaagct ggtgctgaaa gaacctgttt gtcttctaag gctaacgctg   2520

gtagagcttc ttacttgtct tctgaatctt tgttgggtaa catggaccca ggtgctcaaa   2580

gattggctat ggttttcaag gctttggctg aatctgaatt gggttaataa ggtcgagaca   2640

aatcgctctt aaatatatac ctaaagaaca ttaaagctat attataagca aagatacgta   2700

aattttgctt atattattat acacatatca tatttctata tttttaagat ttggttatat   2760

aatgtacgta atgcaaagga aataaatttt atacattatt gaacagcgtc caagtaacta   2820

cattatgtgc actaatagtt tagcgtcgtg aagactttat tgtgtcgcga aaagtaaaaa   2880

ttttaaaaat tagagcacct tgaacttgcg aaaaaggttc tcatcaactg tttaaaacgt   2940

acgaagctta a                                                        2951


<210>  28
<211>  1949
<212>  DNA
<213>  Artificial

<220>
<223>  pRNgldA

<400>  28
actagtaaat gtgtggggaa gcgggtaagc tgccacagca attaatgcac aacatttaac     60

ctacattctt ccttatcgga tcctcaaaac ccttaaaaac atatgcctca ccctaacata    120

ttttccaatt aaccctcaat atttctctgt cacccggcct ctattttcca ttttcttctt    180

tacccgccac gcgttttttt ctttcaaatt tttttcttcc ttcttctttt tcttccacgt    240

cctcttgcat aaataaataa accgttttga aaccaaactc gcctctctct ctcctttttg    300

aaatattttt gggtttgttt gatcctttcc ttcccaatct ctcttgttta atatatattc    360

atttatatca cgctctcttt ttatcttcct ttttttcctc tctcttgtat tcttccttcc    420

cctttctact caaaccaaga agaaaaagaa aaggtcaatc tttgttaaag aataggatct    480

tctactacat cagcttttag atttttcacg cttactgctt ttttcttccc aagatcgaaa    540

atttactgaa ttaactgcag aaaatggaca gaatcatcca atctccaggt aagtacatcc    600

aaggtgctga cgttatcaac agattgggtg aatacttgaa gccattggct gaaagatggt    660

tggttgttgg tgacaagttc gttttgggtt tcgctcaatc taccgttgaa aagtctttca    720

aggacgctgg tttggttgtt gaaatcgctc cattcggtgg tgaatgttct caaaacgaaa    780

tcgacagatt gagaggtatc gctgaaaccg ctcaatgtgg tgctatcttg ggtatcggtg    840

gtggtaagac cttggacacc gctaaggctt tggctcactt catgggtgtt ccagttgcta    900

tcgctccaac catcgcttct accgacgctc catgttctgc tttgtctgtt atctacaccg    960

acgaaggtga attcgacaga tacttgttgt tgccaaacaa cccaaacatg gttatcgttg   1020

acaccaagat cgttgctggt gctccagcta gattgttggc agctggtatc ggtgacgctt   1080

tggctacctg gttcgaagct agagcttgtt ctagatctgg tgctaccacc atggctggtg   1140

gtaagtgtac ccaagctgct ttggctttgg ctgaattgtg ttacaacacc ttgttggaag   1200

aaggtgaaaa ggctatgttg gctgctgaac aacacgttgt taccccagct ttggaaagag   1260

ttatcgaagc taacacctac ttgtctggtg ttggtttcga atctggtggt ttggctgctg   1320

ctcacgctgt tcacaacggt ttgaccgcta tcccagacgc tcaccactac taccacggtg   1380

aaaaggttgc tttcggtacc ttgacccaat tggttttgga aaacgctcca gttgaagaaa   1440

tcgaaaccgt tgctgctttg tctcacgctg ttggtttgcc aatcaccttg gctcaattgg   1500

acatcaagga agacgttcca gctaagatga gaatcgttgc tgaagctgct tgtgctgaag   1560

gtgaaaccat ccacaacatg ccaggtggtg ctaccccaga ccaagtttac gctgctttgt   1620

tggttgctga ccaatacggt caaagattcc tacaagaatg ggaataaggc gcgccccttt   1680

tcctttgtcg atatcatgta attagttatg tcacgcttac attcacgccc tcctcccaca   1740

tccgctctaa ccgaaaagga aggagttaga caacctgaag tctaggtccc tatttatttt   1800

ttttaatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt cttttttttc   1860

tgtacaaacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag aaggttttgg   1920

gacgctcgaa ggcttcctag gcgtacgtt                                     1949


<210>  29
<211>  7690
<212>  DNA
<213>  Artificial

<220>
<223>  pRN558

<400>  29
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca     60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg    120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc    180

accataattc cgttttaaga gcttggtgag cgctaggagt cactgccagg tatcgtttga    240

acacggcatt agtcagggaa gtcataacac agtcctttcc cgcaattttc tttttctatt    300

actcttggcc tcctctagta cactctatat ttttttatgc ctcggtaatg attttcattt    360

ttttttttcc acctagcgga tgactctttt tttttcttag cgattggcat tatcacataa    420

tgaattatac attatataaa gtaatgtgat ttcttcgaag aatatactaa aaaatgagca    480

ggcaagataa acgaaggcaa agatgacaga gcagaaagcc ctagtaaagc gtattacaaa    540

tgaaaccaag attcagattg cgatctcttt aaagggtggt cccctagcga tagagcactc    600

gatcttccca gaaaaagagg cagaagcagt agcagaacag gccacacaat cgcaagtgat    660

taacgtccac acaggtatag ggtttctgga ccatatgata catgctctgg ccaagcattc    720

cggctggtcg ctaatcgttg agtgcattgg tgacttacac atagacgacc atcacaccac    780

tgaagactgc gggattgctc tcggtcaagc ttttaaagag gccctactgg cgcgtggagt    840

aaaaaggttt ggatcaggat ttgcgccttt ggatgaggca ctttccagag cggtggtaga    900

tctttcgaac aggccgtacg cagttgtcga acttggtttg caaagggaga aagtaggaga    960

tctctcttgc gagatgatcc cgcattttct tgaaagcttt gcagaggcta gcagaattac   1020

cctccacgtt gattgtctgc gaggcaagaa tgatcatcac cgtagtgaga gtgcgttcaa   1080

ggctcttgcg gttgccataa gagaagccac ctcgcccaat ggtaccaacg atgttccctc   1140

caccaaaggt gttcttatgt agtgacaccg attatttaaa gctgcagcat acgatatata   1200

tacatgtgta tatatgtata cctatgaatg tcagtaagta tgtatacgaa cagtatgata   1260

ctgaagatga caaggtaatg catcattcta tacgtgtcat tctgaacgag gcgcgctttc   1320

cttttttctt tttgcttttt cttttttttt ctcttgaact cgacggatca tatgcggtgt   1380

gaaataccgc acagatgcgt aaggagaaaa taccgcatca ggaaattgta aacgttaata   1440

ttttgttaaa attcgcgtta aatttttgtt aaatcagctc attttttaac caataggccg   1500

aaatcggcaa aatcccttat aaatcaaaag aatagaccga gatagggttg agtgttgttc   1560

cagtttggaa caagagtcca ctattaaaga acgtggactc caacgtcaaa gggcgaaaaa   1620

ccgtctatca gggcgatggc ccactacgtg aaccatcacc ctaatcaagt tttttggggt   1680

cgaggtgccg taaagcacta aatcggaacc ctaaagggag cccccgattt agagcttgac   1740

ggggaaagcc ggcattgcga ataccgcttc cacaaacatt gctcaaaagt atctctttgc   1800

tatatatctc tgtgctatat ccctatataa cctacccatc cacctttcgc tccttgaact   1860

tgcatctaaa ctcgacctct acatttttta tgtttatctc tagtattact ctttagacaa   1920

aaaaattgta gtaagaacta ttcatagagt gaatcgaaaa caatacgaaa atgtaaacat   1980

ttcctatacg tagtatatag agacaaaata gaagaaaccg ttcataattt tctgaccaat   2040

gaagaatcat caacgctatc actttctgtt cacaaagtat gcgcaatcca catcggtata   2100

gaatataatc ggggatgcct ttatcttgaa aaaatgcacc cgcagcttcg ctagtaatca   2160

gtaaacgcgg gaagtggagt caggcttttt ttatggaaga gaaaatagac accaaagtag   2220

ccttcttcta accttaacgg acctacagtg caaaaagtta tcaagagact gcattataga   2280

gcgcacaaag gagaaaaaaa gtaatctaag atgctttgtt agaaaaatag cgctctcggg   2340

atgcattttt gtagaacaaa aaagaagtat agattctttg ttggtaaaat agcgctctcg   2400

cgttgcattt ctgttctgta aaaatgcagc tcagattctt tgtttgaaaa attagcgctc   2460

tcgtcgcgtt gcatttttgt tttacaaaaa tgaagcacag attcttcgtt ggtaaaatag   2520

cgctttcgcg ttgcatttct gttctgtaaa aatgcagctc agattctttg tttgaaaaat   2580

tagcgctctc gcgttgcatt tttgttctac aaaatgaagc acagatgctt cgttaacaaa   2640

gatatgctat tgaagtgcaa gatggaaacg cagaaaatga accggggatg cgacgtgcaa   2700

gattacctat gcaatagatg caatagtttc tccaggaacc gaaatacata cattgtcttc   2760

cgtaaagcgc tagactatat attattatac aggttcaaat atactatctg tttcagggaa   2820

aactcccagg ttcggatgtt caaaattcaa tgatgggtaa caagtacgat cgtaaatctg   2880

taaaacagtt tgtcggatat taggctgtat ctcctcaaag cgtattcgaa tatcattgag   2940

aagctgcagc gtcacatcgg ataataatga tggcagccat tgtagaagtg ccttttgcat   3000

ttctagtctc tttctcggtc tagctagttt tactacatcg cgaagataga atcttagatc   3060

acactgcctt tgctgagctg gatcaataga gtaacaaaag agtggtaagg cctcgttaaa   3120

ggacaaggac ctgagcggaa gtgtatcgta cagtagacgg agtatctagt atagtctata   3180

gtccgtggaa ttaattctca tctttgacag cttatcatcg ataatccgga gctagcatgc   3240

ggccgccagt gtgatggata tctgcagaat tcgccctttt aagcttcgta cgtgtggaag   3300

aacgattaca acaggtgttg tcctctgagg acataaaata cacaccgaga ttcatcaact   3360

cattgctgga gttagcatat ctacaattgg gtgaaatggg gagcgatttg caggcatttg   3420

ctcggcatgc cggtagaggt gtggtcaata agagcgacct catgctatac ctgagaaagc   3480

aacctgacct acaggaaaga gttactcaag aataagaatt ttcgttttaa aacctaagag   3540

tcactttaaa atttgtatac acttattttt tttataactt atttaataat aaaaatcata   3600

aatcataaga aattcgcgcg cttaagcagc ttcaccagcc tttctagcca aagattgagc   3660

catcttttca gcggtagcca aagcagaaga ggtcataatg tccaagttac cagcgtaagc   3720

tggcaagtag tgagcagcac cttcaacttc caaccaaaca gcggtcttca aaccagagaa   3780

ttgaccaaca cctggcaagt taactggctt gtcttgtggg ataacttcga attgaactct   3840

ttgcttcaat ctgtaacctg gaacgtatgc ttgaacagct tcagccattt cgttgattga   3900

agcttcgatg tcgtcttgag atgcttcgtc agacaaaacg taaacggtgt ctctcatcat   3960

caatggtggt tcagctgggt tcaaaacgat gatagcctta cccttagcag caccaccaac   4020

aacttcgata gccctagagg tggtttcggt gaattcgtcg atgttagctc tggtacctgg   4080

accagcagac ttagaagcga tagaagcgat gatttcagcg tagtgaactc tagcaactct   4140

tgaaacagca gcaaccattg ggatggtagc ttgaccacca caggtaacca tgttaacgtt   4200

taattggtca acgttagctt ccaagttaac aactggaaca cagtatggac cgatagcagc   4260

tggggtcaag tcgatcaatc tgatgtctgg cttagcttct ctcaaagcag cgtcgttctt   4320

aacgtgagca ccagcagagg tagcgtcgaa aacgatgtcg atgtcagcga attctggcat   4380

gttcatcaaa ccgataacac cttcgtgggt ggtagcaaca cccattcttc tagctctagc   4440

caaaccgtca gattgtgggt cgataccaac cataacagcc atttccaagt gttgaccgtg   4500

tcttaggatc ttgatcatca agtcagtacc gatgttacca gaaccgatga tagcaacctt   4560

tctcttagac atctgcagtc tagatatatt tgttgtaaaa agtagataat tacttccttg   4620

atgatctgta aaaaagagaa aaagaaagca tctaagaact tgaaaaacta cgaattagaa   4680

aagaccaaat atgtatttct tgcattgacc aatttatgca agtttatata tatgtaaatg   4740

taagtttcac gaggttctac taaactaaac cacccccttg gttagaagaa aagagtgtgt   4800

gagaacaggc tgttgttgtc acacgattcg gacaattctg tttgaaagag agagagtaac   4860

agtacgatcg aacgaacttt gctctggaga tcacagtggg catcatagca tgtggtacta   4920

aaccctttcc cgccattcca gaaccttcga ttgcttgtta caaaacctgt gagccgtcgc   4980

taggaccttg ttgtgtgacg aaattggaag ctgcaatcaa taggaagaca ggaagtcgag   5040

cgtgtctggg ttttttcagt tttgttcttt ttgcaaacaa atcacgagcg acggtaattt   5100

ctttctcgat aagaggccac gtgctttatg agggtaacat caattcaaga aggagggaaa   5160

cacttccttt ttctggccct gataatagta tgagggtgaa gccaaaataa aggattcgcg   5220

cccaaatcgg catctttaaa tgcaggtatg cgatagttcc tcactctttc cttactcacg   5280

agtaattctt gcaaatgcct attatgcaga tgttataata tctgtgcgtc ttgagttgaa   5340

gagctcgaga ctagtggatc ccccgggctg caggaattcg atatcaagct tatcgatacc   5400

gtcgacctcg agggggggcc cggtacccag cttttgttcc ctttagtgag ggttaattcc   5460

gagcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat   5520

tccacacaac ataggagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag   5580

gtaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg   5640

ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc   5700

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc   5760

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa   5820

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt   5880

tttccatagg ctcggccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg   5940

gcgaaacccg acaggactat aaagatacca ggcgttcccc cctggaagct ccctcgtgcg   6000

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag   6060

cgtggcgctt tctcaatgct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc   6120

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa   6180

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg   6240

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc   6300

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac   6360

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg   6420

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt   6480

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt   6540

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa   6600

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga   6660

ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac tgcccgtcgt   6720

gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg   6780

agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga   6840

gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga   6900

agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg   6960

catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc   7020

aaggcgagtt acatgatccc ccatgttgtg aaaaaaagcg gttagctcct tcggtcctcc   7080

gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca   7140

taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac   7200

caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg   7260

ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc   7320

ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg   7380

tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac   7440

aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat   7500

actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata   7560

catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa   7620

agtgccacct gacgtcttat tatcatgaca ttaacctata aaaataggcg tatcacgagg   7680

ccctttcgtc                                                          7690


<210>  30
<211>  9416
<212>  DNA
<213>  Artificial

<220>
<223>  pRN595

<400>  30
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataagacgtc     60

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca    120

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa    180

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt    240

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca    300

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag    360

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc    420

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca    480

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt    540

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct    600

gacaacgatc ggaggaccga aggagctaac cgcttttttt cacaacatgg gggatcatgt    660

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga    720

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact    780

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc    840

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga    900

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt    960

agttatctac acgacgggca gtcaggcaac tatggatgaa cgaaatagac agatcgctga   1020

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact   1080

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   1140

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   1200

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   1260

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   1320

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   1380

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   1440

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   1500

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   1560

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga   1620

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   1680

aacaggagag cgcacgaggg agcttccagg ggggaacgcc tggtatcttt atagtcctgt   1740

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggccgag   1800

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   1860

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt   1920

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga   1980

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta   2040

atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa   2100

tgtgagttac ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcctat   2160

gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta   2220

cgccaagctc ggaattaacc ctcactaaag ggaacaaaag ctgggtaccg ggccccccct   2280

cgaggtcgac ggtatcgata agcttgatat cgaattcctg cagcccgggg gatccactag   2340

tctcgagctc ttcaactcaa gacgcacaga tattataaca tctgcataat aggcatttgc   2400

aagaattact cgtgagtaag gaaagagtga ggaactatcg catacctgca tttaaagatg   2460

ccgatttggg cgcgaatcct ttattttggc ttcaccctca tactattatc agggccagaa   2520

aaaggaagtg tttccctcct tcttgaattg atgttaccct cataaagcac gtggcctctt   2580

atcgagaaag aaattaccgt cgctcgtgat ttgtttgcaa aaagaacaaa actgaaaaaa   2640

cccagacacg ctcgacttcc tgtcttccta ttgattgcag cttccaattt cgtcacacaa   2700

caaggtccta gcgacggctc acaggttttg taacaagcaa tcgaaggttc tggaatggcg   2760

ggaaagggtt tagtaccaca tgctatgatg cccactgtga tctccagagc aaagttcgtt   2820

cgatcgtact gttactctct ctctttcaaa cagaattgtc cgaatcgtgt gacaacaaca   2880

gcctgttctc acacactctt ttcttctaac caagggggtg gtttagttta gtagaacctc   2940

gtgaaactta catttacata tatataaact tgcataaatt ggtcaatgca agaaatacat   3000

atttggtctt ttctaattcg tagtttttca agttcttaga tgctttcttt ttctcttttt   3060

tacagatcat caaggaagta attatctact ttttacaaca aatatatcta gaaaatggct   3120

gttaccaacg ttgctgaatt gaacgctttg gttgaaaggg ttaagaaggc tcaaagagaa   3180

tacgcttctt tcacccaaga acaagttgac aagatcttca gagctgctgc tttggctgct   3240

gctgacgcta gaatcccatt ggctaagatg gctgttgctg aatctggtat gggtatcgtt   3300

gaagacaagg ttatcaagaa ccacttcgct tctgaataca tctacaacgc ttacaaggac   3360

gaaaagacct gtggtgtttt gtcagaagac gacaccttcg gtaccatcac catcgctgaa   3420

ccaatcggta tcatctgtgg tatcgttcca accaccaacc caacctctac cgctatcttc   3480

aagtctttga tctctttgaa gaccagaaac gctatcatct tctctccaca cccaagagct   3540

aaagacgcta ccaacaaggc tgctgacatc gttttgcaag ctgctatcgc tgctggtgct   3600

ccaaaggact tgatcggttg gatcgaccaa ccatctgttg aattgtctaa cgctttgatg   3660

caccacccag acatcaactt gatcttggct accggtggtc caggtatggt taaggctgct   3720

tactcttctg gtaagccagc tatcggtgtt ggtgctggta acaccccagt tgttatcgac   3780

gaaaccgctg acatcaagag agctgttgct tctgttttga tgtctaagac cttcgacaac   3840

ggtgttatct gtgcttctga acaatctgtt gttgttgttg actctgttta cgacgctgtt   3900

agagaaagat tcgctaccca cggtggttac ttgttgcaag gtaaggaatt gaaggctgtt   3960

caagacgtta tcttgaagaa cggtgctttg aacgctgcta tcgttggtca accagcttac   4020

aagatcgctg aattagctgg tttctctgtt ccagaaaaca ccaagatctt gatcggtgaa   4080

gttaccgttg ttgacgaatc tgaaccattc gctcacgaaa agttgtctcc aaccttggct   4140

atgtacagag ctaaggactt cgaagacgct gttgaaaaag ctgaaaagtt ggttgctatg   4200

ggtggtattg gtcacacctc ttgtttgtac accgaccaag acaaccaacc agctagagtt   4260

tcttacttcg gtcaaaagat gaagaccgct agaatcttga tcaacacccc agcttctcaa   4320

ggtggtatcg gtgacttgta caacttcaag ttggctccat ctttgacctt gggttgtggt   4380

tcttggggtg gtaactctat ctctgaaaac gttggtccaa agcacttgat caacaagaag   4440

accgttgcta agagagctga aaacatgttg tggcacaagt tgccaaaatc tatctacttc   4500

agaagaggtt ctttgccaat cgctttggac gaagttatca ccgacggtca caagagagct   4560

ttgatcgtta ccgacagatt cttgttcaac aacggttacg ctgaccaaat cacctctgtt   4620

ttgaaggctg ctggtgttga aaccgaagtt ttcttcgaag ttgaagctga cccaaccttg   4680

tctatcgtta gaaagggtgc tgaattggct aactctttca agccagacgt tatcatcgct   4740

ttgggtggtg gttctccaat ggacgctgct aagatcatgt gggttatgta cgaacaccca   4800

gaaacccact tcgaagaatt ggctttgaga ttcatggaca tcagaaagag aatctacaag   4860

ttcccaaaga tgggtgttaa ggctaagatg atcgctgtta ccaccacctc tggtaccggt   4920

tctgaagtta ccccattcgc tgttgttacc gacgacgcta ccggtcaaaa gtacccattg   4980

gctgactacg ctttgacccc agacatggct atcgttgacg ctaacttggt tatggacatg   5040

ccaaagtctt tgtgtgcttt cggtggtttg gacgctgtta cccacgctat ggaagcttac   5100

gtttctgttt tggcttctga attctctgac ggtcaagctt tgcaagcttt gaagttgttg   5160

aaggaatact tgccagcttc ttaccacgaa ggttctaaga acccagttgc tagagaaaga   5220

gttcactctg ctgctaccat cgctggtatc gctttcgcta acgctttctt gggtgtttgt   5280

cactctatgg ctcacaagtt gggttctcaa ttccacatcc cacacggttt ggctaacgct   5340

ttgttgatct gtaacgttat cagatacaac gctaacgaca acccaaccaa gcaaaccgct   5400

ttctctcaat acgacagacc acaagctaga agaagatacg ctgaaatcgc tgaccacttg   5460

ggtttgtctg ctccaggtga cagaaccgct gcaaagatcg aaaagttgtt ggcttggttg   5520

gaaaccttga aggctgaatt gggtatccca aagtctatca gagaagctgg tgttcaagaa   5580

gctgacttct tggctaacgt tgacaagttg tctgaagacg ctttcgacga ccaatgtacc   5640

ggtgctaacc caagataccc attgatctct gaattgaagc aaatcttgtt ggacacctac   5700

tacggtagag actacgttga aggtgaaacc gctgctaaga aggaagctgc tccagctaag   5760

gctgaaaaga aggctaagaa gtctgcttag cttaagcgcg cgaatttctt atgatttatg   5820

atttttatta ttaaataagt tataaaaaaa ataagtgtat acaaatttta aagtgactct   5880

taggttttaa aacgaaaatt cttattcttg agtaactctt tcctgtaggt caggttgctt   5940

tctcaggtat agcatgaggt cgctcttatt gaccacacct ctaccggcat gccgagcaaa   6000

tgcctgcaaa tcgctcccca tttcacccaa ttgtagatat gctaactcca gcaatgagtt   6060

gatgaatctc ggtgtgtatt ttatgtcctc agaggacaac acctgttgta atcgttcttc   6120

cacacgtacg aagcttaaaa gggcgaattc tgcagatatc catcacactg gcggccgcat   6180

gctagctccg gattatcgat gataagctgt caaagatgag aattaattcc acggactata   6240

gactatacta gatactccgt ctactgtacg atacacttcc gctcaggtcc ttgtccttta   6300

acgaggcctt accactcttt tgttactcta ttgatccagc tcagcaaagg cagtgtgatc   6360

taagattcta tcttcgcgat gtagtaaaac tagctagacc gagaaagaga ctagaaatgc   6420

aaaaggcact tctacaatgg ctgccatcat tattatccga tgtgacgctg cagcttctca   6480

atgatattcg aatacgcttt gaggagatac agcctaatat ccgacaaact gttttacaga   6540

tttacgatcg tacttgttac ccatcattga attttgaaca tccgaacctg ggagttttcc   6600

ctgaaacaga tagtatattt gaacctgtat aataatatat agtctagcgc tttacggaag   6660

acaatgtatg tatttcggtt cctggagaaa ctattgcatc tattgcatag gtaatcttgc   6720

acgtcgcatc cccggttcat tttctgcgtt tccatcttgc acttcaatag catatctttg   6780

ttaacgaagc atctgtgctt cattttgtag aacaaaaatg caacgcgaga gcgctaattt   6840

ttcaaacaaa gaatctgagc tgcattttta cagaacagaa atgcaacgcg aaagcgctat   6900

tttaccaacg aagaatctgt gcttcatttt tgtaaaacaa aaatgcaacg cgacgagagc   6960

gctaattttt caaacaaaga atctgagctg catttttaca gaacagaaat gcaacgcgag   7020

agcgctattt taccaacaaa gaatctatac ttcttttttg ttctacaaaa atgcatcccg   7080

agagcgctat ttttctaaca aagcatctta gattactttt tttctccttt gtgcgctcta   7140

taatgcagtc tcttgataac tttttgcact gtaggtccgt taaggttaga agaaggctac   7200

tttggtgtct attttctctt ccataaaaaa agcctgactc cacttcccgc gtttactgat   7260

tactagcgaa gctgcgggtg cattttttca agataaaggc atccccgatt atattctata   7320

ccgatgtgga ttgcgcatac tttgtgaaca gaaagtgata gcgttgatga ttcttcattg   7380

gtcagaaaat tatgaacggt ttcttctatt ttgtctctat atactacgta taggaaatgt   7440

ttacattttc gtattgtttt cgattcactc tatgaatagt tcttactaca atttttttgt   7500

ctaaagagta atactagaga taaacataaa aaatgtagag gtcgagttta gatgcaagtt   7560

caaggagcga aaggtggatg ggtaggttat atagggatat agcacagaga tatatagcaa   7620

agagatactt ttgagcaatg tttgtggaag cggtattcgc aatgccggct ttccccgtca   7680

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc   7740

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt   7800

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac   7860

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc   7920

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt   7980

aacgtttaca atttcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac   8040

cgcatatgat ccgtcgagtt caagagaaaa aaaaagaaaa agcaaaaaga aaaaaggaaa   8100

gcgcgcctcg ttcagaatga cacgtataga atgatgcatt accttgtcat cttcagtatc   8160

atactgttcg tatacatact tactgacatt cataggtata catatataca catgtatata   8220

tatcgtatgc tgcagcttta aataatcggt gtcactacat aagaacacct ttggtggagg   8280

gaacatcgtt ggtaccattg ggcgaggtgg cttctcttat ggcaaccgca agagccttga   8340

acgcactctc actacggtga tgatcattct tgcctcgcag acaatcaacg tggagggtaa   8400

ttctgctagc ctctgcaaag ctttcaagaa aatgcgggat catctcgcaa gagagatctc   8460

ctactttctc cctttgcaaa ccaagttcga caactgcgta cggcctgttc gaaagatcta   8520

ccaccgctct ggaaagtgcc tcatccaaag gcgcaaatcc tgatccaaac ctttttactc   8580

cacgcgccag tagggcctct ttaaaagctt gaccgagagc aatcccgcag tcttcagtgg   8640

tgtgatggtc gtctatgtgt aagtcaccaa tgcactcaac gattagcgac cagccggaat   8700

gcttggccag agcatgtatc atatggtcca gaaaccctat acctgtgtgg acgttaatca   8760

cttgcgattg tgtggcctgt tctgctactg cttctgcctc tttttctggg aagatcgagt   8820

gctctatcgc taggggacca ccctttaaag agatcgcaat ctgaatcttg gtttcatttg   8880

taatacgctt tactagggct ttctgctctg tcatctttgc cttcgtttat cttgcctgct   8940

cattttttag tatattcttc gaagaaatca cattacttta tataatgtat aattcattat   9000

gtgataatgc caatcgctaa gaaaaaaaaa gagtcatccg ctaggtggaa aaaaaaaaat   9060

gaaaatcatt accgaggcat aaaaaaatat agagtgtact agaggaggcc aagagtaata   9120

gaaaaagaaa attgcgggaa aggactgtgt tatgacttcc ctgactaatg ccgtgttcaa   9180

acgatacctg gcagtgactc ctagcgctca ccaagctctt aaaacggaat tatggtgcac   9240

tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc cgccaacacc   9300

cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac   9360

cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcga       9416


<210>  31
<211>  9352
<212>  DNA
<213>  Artificial

<220>
<223>  pRN596

<400>  31
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataagacgtc     60

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca    120

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa    180

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt    240

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca    300

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag    360

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc    420

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca    480

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt    540

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct    600

gacaacgatc ggaggaccga aggagctaac cgcttttttt cacaacatgg gggatcatgt    660

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga    720

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact    780

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc    840

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga    900

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt    960

agttatctac acgacgggca gtcaggcaac tatggatgaa cgaaatagac agatcgctga   1020

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact   1080

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   1140

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   1200

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   1260

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   1320

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   1380

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   1440

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   1500

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   1560

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga   1620

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   1680

aacaggagag cgcacgaggg agcttccagg ggggaacgcc tggtatcttt atagtcctgt   1740

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggccgag   1800

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   1860

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt   1920

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga   1980

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta   2040

atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa   2100

tgtgagttac ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcctat   2160

gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta   2220

cgccaagctc ggaattaacc ctcactaaag ggaacaaaag ctgggtaccg ggccccccct   2280

cgaggtcgac ggtatcgata agcttgatat cgaattcctg cagcccgggg gatccactag   2340

tctcgagctc ttcaactcaa gacgcacaga tattataaca tctgcataat aggcatttgc   2400

aagaattact cgtgagtaag gaaagagtga ggaactatcg catacctgca tttaaagatg   2460

ccgatttggg cgcgaatcct ttattttggc ttcaccctca tactattatc agggccagaa   2520

aaaggaagtg tttccctcct tcttgaattg atgttaccct cataaagcac gtggcctctt   2580

atcgagaaag aaattaccgt cgctcgtgat ttgtttgcaa aaagaacaaa actgaaaaaa   2640

cccagacacg ctcgacttcc tgtcttccta ttgattgcag cttccaattt cgtcacacaa   2700

caaggtccta gcgacggctc acaggttttg taacaagcaa tcgaaggttc tggaatggcg   2760

ggaaagggtt tagtaccaca tgctatgatg cccactgtga tctccagagc aaagttcgtt   2820

cgatcgtact gttactctct ctctttcaaa cagaattgtc cgaatcgtgt gacaacaaca   2880

gcctgttctc acacactctt ttcttctaac caagggggtg gtttagttta gtagaacctc   2940

gtgaaactta catttacata tatataaact tgcataaatt ggtcaatgca agaaatacat   3000

atttggtctt ttctaattcg tagtttttca agttcttaga tgctttcttt ttctcttttt   3060

tacagatcat caaggaagta attatctact ttttacaaca aatatatcta gaaaatgtct   3120

acccaacaaa ccatgaccgt tgacgaacac atcaaccaat tagttagaaa ggctcaagtt   3180

gctttgaagg aatacttgaa gccagaatac acccaagaaa agatcgacta catcgttaag   3240

aaggcttctg ttgctgcttt ggaccaacac tgtgctttgg ctgctgctgc tgttgaagaa   3300

accggtagag gtatcttcga agacaaggct accaagaaca tcttcgcttg tgaacacgtt   3360

acccacgaaa tgagacacgc taagaccgtt ggtatcatca acgttgaccc attgtacggt   3420

atcaccgaaa tcgctgaacc agttggtgtt gtttgtggtg ttaccccagt taccaaccca   3480

acctctaccg ctatcttcaa gtctttgatc tctatcaaga ccagaaaccc aatcgttttc   3540

tctttccacc catctgcttt gaagtgttct attatggctg ctaaaatcgt tagagacgct   3600

gctatcgctg ctggtgctcc agaaaactgt atccaatgga tcgaattcgg tggtatcgaa   3660

gcttctaaca agttgatgaa ccacccaggt gttgctacta tcttggctac cggtggtaac   3720

gctatggtta aggctgcata ctcttctggt aagccagctt tgggtgttgg tgctggtaac   3780

gttccaacct acatcgaaaa gacctgtaac atcaagcaag ctgctaacga cgttgttatg   3840

tctaagtctt tcgacaacgg tatgatctgt gcttctgaac aagctgctat catcgacaag   3900

gaaatctacg accaagttgt tgaagaaatg aagaccttgg gtgcttactt catcaacgaa   3960

gaagaaaagg ctaagttgga aaagttcatg ttcggtgtta acgcttactc tgctgacgtt   4020

aacaacgcta gattgaaccc aaagtgtcca ggtatgtctc cacaatggtt cgctgaacaa   4080

gttggtatca aggtaccaga agactgtaac atcatctgtg ctgtttgtaa ggaagttggt   4140

ccaaacgaac cattgaccag agaaaagttg tctccagttt tggctatctt gaaagctgaa   4200

aacacccaag acggtatcga caaggctgaa gctatggttg aatttaacgg tagaggtcac   4260

tctgctgcta tccactctaa cgacaaggct gttgttgaaa agtacgcttt gaccatgaag   4320

gcttgtagaa tcttgcacaa caccccatct tctcaaggtg gtatcggttc tatctacaac   4380

tacatctggc catctttcac cttgggttgt ggttcttacg gtggtaactc tgtttctgct   4440

aacgttacct accacaactt gttgaacatc aagagattgg ctgacagaag aaacaacttg   4500

caatggttca gagttccacc aaagatcttc ttcgaaccac actctatcag atacttggct   4560

gaattgaagg aattgtctaa gatcttcatc gtttctgaca gaatgatgta caagttgggt   4620

tacgttgaca gagttatgga cgttttgaag agaagatcta acgaagttga aatcgaaatc   4680

ttcatcgacg ttgaaccaga cccatctatc caaaccgttc aaaagggttt ggctgttatg   4740

aacaccttcg gtccagacaa catcatcgct atcggtggtg gttctgctat ggacgctgct   4800

aagatcatgt ggttgttgta cgaacaccca gaagctgact tcttcgctat gaagcaaaag   4860

ttcatcgact tgagaaagag agctttcaag ttcccaacca tgggtaagaa ggctagattg   4920

atctgtatcc caaccacctc tggtaccggt tctgaagtta ccccattcgc tgttatctct   4980

gaccacgaaa ccggtaagaa gtacccattg gctgactact ctttgacccc atctgttgct   5040

atcgttgacc caatgttcac catgtctttg ccaaagagag ctatcgctga caccggtttg   5100

gacgttttgg ttcacgctac cgaagcttac gtttctgtta tggctaacga atacaccgac   5160

ggtttggcta gagaagctgt taagttggtt tttgaaaact tgttgaagtc ttacaacggt   5220

gacttggaag ctagagaaaa gatgcacaac gctgctacca tcgctggtat ggctttcgct   5280

tctgctttct tgggtatgga ccactctatg gctcacaagg ttggtgctgc tttccacttg   5340

ccacacggta gatgtgttgc tgttttgttg ccacacgtta tcagatacaa cggtcaaaag   5400

ccaagaaagt tggctatgtg gccaaagtac aacttctaca aggctgacca aagatacatg   5460

gaattggctc aaatggttgg tttgaagtgt aacaccccag ctgaaggtgt tgaagctttc   5520

gctaaggctt gtgaagaatt gatgaaggct accgaaacca tcaccggttt caagaaggct   5580

aacatcgacg aagctgcttg gatgtctaag gttccagaaa tggctttgtt ggctttcgaa   5640

gaccaatgtt ctccagctaa cccaagagtt ccaatggtta aggacatgga aaagatcttg   5700

aaggctgctt actacccaat cgcttagctt aagcgcgcga atttcttatg atttatgatt   5760

tttattatta aataagttat aaaaaaaata agtgtataca aattttaaag tgactcttag   5820

gttttaaaac gaaaattctt attcttgagt aactctttcc tgtaggtcag gttgctttct   5880

caggtatagc atgaggtcgc tcttattgac cacacctcta ccggcatgcc gagcaaatgc   5940

ctgcaaatcg ctccccattt cacccaattg tagatatgct aactccagca atgagttgat   6000

gaatctcggt gtgtatttta tgtcctcaga ggacaacacc tgttgtaatc gttcttccac   6060

acgtacgaag ctaaaagggc gaattctgca gatatccatc acactggcgg ccgcatgcta   6120

gctccggatt atcgatgata agctgtcaaa gatgagaatt aattccacgg actatagact   6180

atactagata ctccgtctac tgtacgatac acttccgctc aggtccttgt cctttaacga   6240

ggccttacca ctcttttgtt actctattga tccagctcag caaaggcagt gtgatctaag   6300

attctatctt cgcgatgtag taaaactagc tagaccgaga aagagactag aaatgcaaaa   6360

ggcacttcta caatggctgc catcattatt atccgatgtg acgctgcagc ttctcaatga   6420

tattcgaata cgctttgagg agatacagcc taatatccga caaactgttt tacagattta   6480

cgatcgtact tgttacccat cattgaattt tgaacatccg aacctgggag ttttccctga   6540

aacagatagt atatttgaac ctgtataata atatatagtc tagcgcttta cggaagacaa   6600

tgtatgtatt tcggttcctg gagaaactat tgcatctatt gcataggtaa tcttgcacgt   6660

cgcatccccg gttcattttc tgcgtttcca tcttgcactt caatagcata tctttgttaa   6720

cgaagcatct gtgcttcatt ttgtagaaca aaaatgcaac gcgagagcgc taatttttca   6780

aacaaagaat ctgagctgca tttttacaga acagaaatgc aacgcgaaag cgctatttta   6840

ccaacgaaga atctgtgctt catttttgta aaacaaaaat gcaacgcgac gagagcgcta   6900

atttttcaaa caaagaatct gagctgcatt tttacagaac agaaatgcaa cgcgagagcg   6960

ctattttacc aacaaagaat ctatacttct tttttgttct acaaaaatgc atcccgagag   7020

cgctattttt ctaacaaagc atcttagatt actttttttc tcctttgtgc gctctataat   7080

gcagtctctt gataactttt tgcactgtag gtccgttaag gttagaagaa ggctactttg   7140

gtgtctattt tctcttccat aaaaaaagcc tgactccact tcccgcgttt actgattact   7200

agcgaagctg cgggtgcatt ttttcaagat aaaggcatcc ccgattatat tctataccga   7260

tgtggattgc gcatactttg tgaacagaaa gtgatagcgt tgatgattct tcattggtca   7320

gaaaattatg aacggtttct tctattttgt ctctatatac tacgtatagg aaatgtttac   7380

attttcgtat tgttttcgat tcactctatg aatagttctt actacaattt ttttgtctaa   7440

agagtaatac tagagataaa cataaaaaat gtagaggtcg agtttagatg caagttcaag   7500

gagcgaaagg tggatgggta ggttatatag ggatatagca cagagatata tagcaaagag   7560

atacttttga gcaatgtttg tggaagcggt attcgcaatg ccggctttcc ccgtcaagct   7620

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa   7680

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc   7740

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca   7800

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat   7860

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg   7920

tttacaattt cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca   7980

tatgatccgt cgagttcaag agaaaaaaaa agaaaaagca aaaagaaaaa aggaaagcgc   8040

gcctcgttca gaatgacacg tatagaatga tgcattacct tgtcatcttc agtatcatac   8100

tgttcgtata catacttact gacattcata ggtatacata tatacacatg tatatatatc   8160

gtatgctgca gctttaaata atcggtgtca ctacataaga acacctttgg tggagggaac   8220

atcgttggta ccattgggcg aggtggcttc tcttatggca accgcaagag ccttgaacgc   8280

actctcacta cggtgatgat cattcttgcc tcgcagacaa tcaacgtgga gggtaattct   8340

gctagcctct gcaaagcttt caagaaaatg cgggatcatc tcgcaagaga gatctcctac   8400

tttctccctt tgcaaaccaa gttcgacaac tgcgtacggc ctgttcgaaa gatctaccac   8460

cgctctggaa agtgcctcat ccaaaggcgc aaatcctgat ccaaaccttt ttactccacg   8520

cgccagtagg gcctctttaa aagcttgacc gagagcaatc ccgcagtctt cagtggtgtg   8580

atggtcgtct atgtgtaagt caccaatgca ctcaacgatt agcgaccagc cggaatgctt   8640

ggccagagca tgtatcatat ggtccagaaa ccctatacct gtgtggacgt taatcacttg   8700

cgattgtgtg gcctgttctg ctactgcttc tgcctctttt tctgggaaga tcgagtgctc   8760

tatcgctagg ggaccaccct ttaaagagat cgcaatctga atcttggttt catttgtaat   8820

acgctttact agggctttct gctctgtcat ctttgccttc gtttatcttg cctgctcatt   8880

ttttagtata ttcttcgaag aaatcacatt actttatata atgtataatt cattatgtga   8940

taatgccaat cgctaagaaa aaaaaagagt catccgctag gtggaaaaaa aaaaatgaaa   9000

atcattaccg aggcataaaa aaatatagag tgtactagag gaggccaaga gtaatagaaa   9060

aagaaaattg cgggaaagga ctgtgttatg acttccctga ctaatgccgt gttcaaacga   9120

tacctggcag tgactcctag cgctcaccaa gctcttaaaa cggaattatg gtgcactctc   9180

agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct   9240

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc   9300

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc ga           9352


<210>  32
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Primer GPD2uf

<400>  32
ggtaccagat cttttgcggc gaggtgccg                                       29


<210>  33
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Primer GPD2ur

<400>  33
tctagactta aggaatgtgt atcttgttaa tcttctgaca gc                        42


<210>  34
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Primer GPD2df

<400>  34
ctcgagatag tctacaacaa cgtccgca                                        28


<210>  35
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Primer GPD2dr

<400>  35
ccatggagat ctgcagtgaa aaagctcgaa gaaacagct                            39


<210>  36
<211>  4397
<212>  DNA
<213>  Artificial

<220>
<223>  pRN594

<400>  36
gacgacggcg acctggcggg cttcgtggtc gtctcgtact ccggctggaa ccgccggctg     60

accgtcgagg acatcgaggt cgccccggag caccgggggc acggggtcgg gcgcgcgttg    120

atggggctcg cgacggagtt cgcccgcgag cggggcgccg ggcacctctg gctggaggtc    180

accaacgtca acgcaccggc gatccacgcg taccggcgga tggggttcac cctctgcggc    240

ctggacaccg ccctgtacga cggcaccgcc tcggacggcg agcaggcgct ctacatgagc    300

atgccctgcc cctagtactg acaataaaaa gattcttgtt ttcaagaact tgtcatttgt    360

atagtttttt tatattgtag ttgttctatt ttaatcaaat gttagcgtga tttatatttt    420

ttttcgcctc gacatcatct gcccagatgc gaagttaagt gcgcagaaag taatatcatg    480

cgtcaatcgt atgtgaatgc tggtcgctat actgctgtcg attcgatact aacgccgcca    540

tccagtgtcg acggatccta ggtgtacagg gcccaaaagg gcgaattctg cagatatcca    600

tcacactggc ggccgctcga gatagtctac aacaacgtcc gcatggaaga cctaccggag    660

atgattgaag agctagacat cgatgacgaa tagacactct ccccccccct ccccctctga    720

tctttcctgt tgcctctttt tcccccaacc aatttatcat tatacacaag ttctacaact    780

actactagta acattactac agttattata attttctatt ctctttttct ttaagaatct    840

atcattaacg ttaatttcta tatatacata actaccatta tacacgctat tatcgtttac    900

atatcacatc accgttaatg aaagatacga caccctgtac actaacacaa ttaaataatc    960

gccataacct tttctgttat ctatagccct taaagctgtt tcttcgagct ttttcactgc   1020

agatctccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg   1080

attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag cgttggctac   1140

ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg tgctttacgg   1200

tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg agttcttctg   1260

aattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt   1320

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct   1380

gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc   1440

cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta   1500

tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac   1560

tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc   1620

atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac   1680

ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg   1740

gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac   1800

gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc   1860

gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt   1920

gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga   1980

gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc   2040

cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag   2100

atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca   2160

tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc   2220

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca   2280

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc   2340

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta   2400

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt   2460

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc   2520

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg   2580

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg   2640

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag   2700

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc   2760

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat   2820

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg   2880

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc   2940

tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt   3000

accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca   3060

gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg   3120

attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac   3180

gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg   3240

gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa cagctatgac   3300

catgattacg ccaagctatt taggtgacac tatagaatac tcaagctatg catcaagctt   3360

ggtaccagat cttttgcggc gaggtgccga tgggttgctg aggggaagag tgtttagctt   3420

acggacctat tgccattgtt attccgatta atctattgtt cagcagctct tctctaccct   3480

gtcattctag tatttttttt tttttttttt ggttttactt ttttttcttc ttgccttttt   3540

ttcttgttac tttttttcta gttttttttc cttccactaa gctttttcct tgatttatcc   3600

ttgggttctt ctttctactc ctttagattt tttttttata tattaatttt taagtttatg   3660

tattttggta gattcaattc tctttccctt tccttttcct tcgctcccct tccttatcaa   3720

tgcttgctgt cagaagatta acaagataca cattccttaa ggcctcgtcc ccgccgggtc   3780

acccggccag cgacatggag gcccagaata ccctccttga cagtcttgac gtgcgcagct   3840

caggggcatg atgtgactgt cgcccgtaca tttagcccat acatccccat gtataatcat   3900

ttgcatccat acattttgat ggccgcacgg cgcgaagcaa aaattacggc tcctcgctgc   3960

agacctgcga gcagggaaac gctcccctca cagacgcgtt gaattgtccc cacgccgcgc   4020

ccctgtagag aaatataaaa ggttaggatt tgccactgag gttcttcttt catatacttc   4080

cttttaaaat cttgctagga tacagttctc acatcacatc cgaacataaa caaccatgta   4140

aaatgaccac tcttgacgac acggcttacc ggtaccgcac cagtgtcccg ggggacgccg   4200

aggccatcga ggcactggat gggtccttca ccaccgacac cgtcttccgc gtcaccgcca   4260

ccggggacgg cttcaccctg cgggaggtgc cggtggaccc gcccctgacc aaggtgttcc   4320

ccgacgacga atcggacgac gaatcggacg ccggggagga cggcgacccg gactcccgga   4380

cgttcgtcgc gtacggg                                                  4397


<210>  37
<211>  14200
<212>  DNA
<213>  Artificial

<220>
<223>  pRN957

<400>  37
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataagacgtc     60

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca    120

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa    180

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt    240

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca    300

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag    360

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc    420

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca    480

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt    540

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct    600

gacaacgatc ggaggaccga aggagctaac cgcttttttt cacaacatgg gggatcatgt    660

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga    720

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact    780

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc    840

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga    900

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt    960

agttatctac acgacgggca gtcaggcaac tatggatgaa cgaaatagac agatcgctga   1020

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact   1080

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   1140

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   1200

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   1260

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   1320

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   1380

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   1440

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   1500

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   1560

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga   1620

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   1680

aacaggagag cgcacgaggg agcttccagg ggggaacgcc tggtatcttt atagtcctgt   1740

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggccgag   1800

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   1860

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt   1920

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga   1980

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta   2040

atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa   2100

tgtgagttac ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcctat   2160

gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta   2220

cgccaagctc ggaattaacc ctcactaaag ggaacaaaag ctgggtaccg ggccccccct   2280

cgaggtcgag cttaagacgc gtttcttctt cagattccct catggagaaa gtgcggcaga   2340

tgtatatgac agagtcgcca gtttccaaga gactttattc aggcacttcc atgataggca   2400

agagagaaga cccagagatg ttgttgtcct agttacacat ggtatttatt ccagagtatt   2460

cctgatgaaa tggtttagat ggacatacga agagtttgaa tcgtttacca atgttcctaa   2520

cgggagcgta atggtgatgg aactggacga atccatcaat agatacgtcc tgaggaccgt   2580

gctacccaaa tggactgatt gtgagggaga cctaactaca tagtgtttaa agattacgga   2640

tatttaactt acttagaata atgccatttt tttgagttat aataatccta cgttagtgtg   2700

agcgggattt aaactgtgag gaccttaata cattcagaca cttctgcggt atcaccctac   2760

ttattccctt cgagattata tctaggaacc catcaggttg gtggaagatt acccgttcta   2820

agacttttca gcttcctcta ttgatgttac acctggacac cccttttctg gcatccagtt   2880

tttaatcttc agtggcatgt gagattctcc gaaattaatt aaagcaatca cacaattctc   2940

tcggatacca cctcggttga aactgacagg tggtttgtta cgcatgctaa tgcaaaggag   3000

cctatatacc tttggctcgg ctgctgtaac agggaatata aagggcagca taatttagga   3060

gtttagtgaa cttgcaacat ttactatttt cccttcttac gtaaatattt ttctttttaa   3120

ttctaaatca atctttttca attttttgtt tgtattcttt tcttgcttaa atctataact   3180

acaaaaaaca catacataaa tctagaaaaa tgtctcaatt cttcttcaac cagagaaccc   3240

acttggtttc tgacgttatc gacggtgcta tcatcgcttc accatggaac aatttggcta   3300

gattggaatc tgacccagct atcagaatcg ttgttagaag agacttgaac aagaacaacg   3360

ttgctgttat ctctggtggt ggttctggtc acgaaccagc tcacgttggt ttcatcggta   3420

agggtatgtt gaccgctgct gtttgtggtg acgttttcgc ttctccatct gttgacgctg   3480

ttttgactgc tatccaagct gttaccggtg aagctggttg tttgttgatc gttaagaact   3540

acaccggtga cagattgaac ttcggtttgg ctgctgaaaa ggctagaaga ttgggttaca   3600

acgttgaaat gttgatcgtt ggtgacgaca tctctttgcc agacaacaag cacccaagag   3660

gtatcgctgg taccatcttg gttcacaaga tcgctggtta cttcgctgaa agaggttaca   3720

acttagctac cgttttgaga gaagctcaat acgctgcttc taacaccttc tctttgggtg   3780

ttgctttgtc ttcttgtcac ttgccacaag aaaccgacgc tgctccaaga caccacccag   3840

gtcacgctga attgggtatg ggtatccacg gtgaaccagg tgcttctgtt atcgacaccc   3900

aaaactctgc tcaagttgtt aacttgatgg ttgacaagtt gttggctgct ttgccagaaa   3960

ccggtagatt ggctgttatg atcaacaact tgggtggtgt ttctgttgct gaaatggcta   4020

tcatcaccag agaattggct tcttctccat tgcactcaag aatcgactgg ttgatcggtc   4080

cagcttcttt ggtaaccgct ttggacatga agggtttctc tttgaccgct atcgttttgg   4140

aagaatctat cgaaaaggct ttgttgaccg aagttgaaac ctctaactgg ccaaccccag   4200

ttccaccaag agaaatcacc tgtgttgttt cttctcacgc ttctgctaga gttgaattcc   4260

aaccatctgc taacgctttg gttgctggta tcgttgaatt ggttaccgct accttgtctg   4320

acttggaaac ccacttgaac gctttggacg ctaaggttgg tgacggtgac accggttcta   4380

ccttcgctgc tgctgctaga gaaatcgctt ctttgttgca cagacaacaa ttgccattga   4440

acaacttggc taccttgttc gctttgatcg gtgaaagatt gaccgttgtt atgggtggtt   4500

cttctggtgt tttgatgtct atcttcttca ccgctgctgg tcaaaagttg gaacaaggtg   4560

ctaacgttgt tgaagctttg aacaccggtt tggctcaaat gaagttctac ggtggtgctg   4620

acgaaggtga cagaaccatg atcgacgctt tgcaaccagc tttgacctct ttgttggctc   4680

aaccaaagaa cttgcaagct gctttcgacg ctgctcaagc tggtgctgaa agaacctgtt   4740

tgtcttctaa ggctaacgct ggtagagctt cttacttgtc ttctgaatct ttgttgggta   4800

acatggaccc aggtgctcaa agattggcta tggttttcaa ggctttggct gaatctgaat   4860

tgggttaata aggtcgagac aaatcgctct taaatatata cctaaagaac attaaagcta   4920

tattataagc aaagatacgt aaattttgct tatattatta tacacatatc atatttctat   4980

atttttaaga tttggttata taatgtacgt aatgcaaagg aaataaattt tatacattat   5040

tgaacagcgt ccaagtaact acattatgtg cactaatagt ttagcgtcgt gaagacttta   5100

ttgtgtcgcg aaaagtaaaa attttaaaaa ttagagcacc ttgaacttgc gaaaaaggtt   5160

ctcatcaact gtttaaaacg tacgcctagg aagccttcga gcgtcccaaa accttctcaa   5220

gcaaggtttt cagtataatg ttacatgcgt acacgcgttt gtacagaaaa aaaagaaaaa   5280

tttgaaatat aaataacgtt cttaatacta acataactat taaaaaaaat aaatagggac   5340

ctagacttca ggttgtctaa ctccttcctt ttcggttaga gcggatgtgg gaggagggcg   5400

tgaatgtaag cgtgacataa ctaattacat gatatcgaca aaggaaaagg ggcgcgcctt   5460

attcccattc ttgtaggaat ctttgaccgt attggtcagc aaccaacaaa gcagcgtaaa   5520

cttggtctgg ggtagcacca cctggcatgt tgtggatggt ttcaccttca gcacaagcag   5580

cttcagcaac gattctcatc ttagctggaa cgtcttcctt gatgtccaat tgagccaagg   5640

tgattggcaa accaacagcg tgagacaaag cagcaacggt ttcgatttct tcaactggag   5700

cgttttccaa aaccaattgg gtcaaggtac cgaaagcaac cttttcaccg tggtagtagt   5760

ggtgagcgtc tgggatagcg gtcaaaccgt tgtgaacagc gtgagcagca gccaaaccac   5820

cagattcgaa accaacacca gacaagtagg tgttagcttc gataactctt tccaaagctg   5880

gggtaacaac gtgttgttca gcagccaaca tagccttttc accttcttcc aacaaggtgt   5940

tgtaacacaa ttcagccaaa gccaaagcag cttgggtaca cttaccacca gccatggtgg   6000

tagcaccaga tctagaacaa gctctagctt cgaaccaggt agccaaagcg tcaccgatac   6060

cagctgccaa caatctagct ggagcaccag caacgatctt ggtgtcaacg ataaccatgt   6120

ttgggttgtt tggcaacaac aagtatctgt cgaattcacc ttcgtcggtg tagataacag   6180

acaaagcaga acatggagcg tcggtagaag cgatggttgg agcgatagca actggaacac   6240

ccatgaagtg agccaaagcc ttagcggtgt ccaaggtctt accaccaccg atacccaaga   6300

tagcaccaca ttgagcggtt tcagcgatac ctctcaatct gtcgatttcg ttttgagaac   6360

attcaccacc gaatggagcg atttcaacaa ccaaaccagc gtccttgaaa gacttttcaa   6420

cggtagattg agcgaaaccc aaaacgaact tgtcaccaac aaccaaccat ctttcagcca   6480

atggcttcaa gtattcaccc aatctgttga taacgtcagc accttggatg tacttacctg   6540

gagattggat gattctgtcc attttctgca gttaattcag taaattttcg atcttgggaa   6600

gaaaaaagca gtaagcgtga aaaatctaaa agctgatgta gtagaagatc ctattcttta   6660

acaaagattg accttttctt tttcttcttg gtttgagtag aaaggggaag gaagaataca   6720

agagagagga aaaaaaggaa gataaaaaga gagcgtgata taaatgaata tatattaaac   6780

aagagagatt gggaaggaaa ggatcaaaca aacccaaaaa tatttcaaaa aggagagaga   6840

gaggcgagtt tggtttcaaa acggtttatt tatttatgca agaggacgtg gaagaaaaag   6900

aagaaggaag aaaaaaattt gaaagaaaaa aacgcgtggc gggtaaagaa gaaaatggaa   6960

aatagaggcc gggtgacaga gaaatattga gggttaattg gaaaatatgt tagggtgagg   7020

catatgtttt taagggtttt gaggatccga taaggaagaa tgtaggttaa atgttgtgca   7080

ttaattgctg tggcagctta cccgcttccc cacacattta ctagtctcga gctcttcaac   7140

tcaagacgca cagatattat aacatctgca taataggcat ttgcaagaat tactcgtgag   7200

taaggaaaga gtgaggaact atcgcatacc tgcatttaaa gatgccgatt tgggcgcgaa   7260

tcctttattt tggcttcacc ctcatactat tatcagggcc agaaaaagga agtgtttccc   7320

tccttcttga attgatgtta ccctcataaa gcacgtggcc tcttatcgag aaagaaatta   7380

ccgtcgctcg tgatttgttt gcaaaaagaa caaaactgaa aaaacccaga cacgctcgac   7440

ttcctgtctt cctattgatt gcagcttcca atttcgtcac acaacaaggt cctagcgacg   7500

gctcacaggt tttgtaacaa gcaatcgaag gttctggaat ggcgggaaag ggtttagtac   7560

cacatgctat gatgcccact gtgatctcca gagcaaagtt cgttcgatcg tactgttact   7620

ctctctcttt caaacagaat tgtccgaatc gtgtgacaac aacagcctgt tctcacacac   7680

tcttttcttc taaccaaggg ggtggtttag tttagtagaa cctcgtgaaa cttacattta   7740

catatatata aacttgcata aattggtcaa tgcaagaaat acatatttgg tcttttctaa   7800

ttcgtagttt ttcaagttct tagatgcttt ctttttctct tttttacaga tcatcaagga   7860

agtaattatc tactttttac aacaaatata tctagaaaat ggctgttacc aacgttgctg   7920

aattgaacgc tttggttgaa agggttaaga aggctcaaag agaatacgct tctttcaccc   7980

aagaacaagt tgacaagatc ttcagagctg ctgctttggc tgctgctgac gctagaatcc   8040

cattggctaa gatggctgtt gctgaatctg gtatgggtat cgttgaagac aaggttatca   8100

agaaccactt cgcttctgaa tacatctaca acgcttacaa ggacgaaaag acctgtggtg   8160

ttttgtcaga agacgacacc ttcggtacca tcaccatcgc tgaaccaatc ggtatcatct   8220

gtggtatcgt tccaaccacc aacccaacct ctaccgctat cttcaagtct ttgatctctt   8280

tgaagaccag aaacgctatc atcttctctc cacacccaag agctaaagac gctaccaaca   8340

aggctgctga catcgttttg caagctgcta tcgctgctgg tgctccaaag gacttgatcg   8400

gttggatcga ccaaccatct gttgaattgt ctaacgcttt gatgcaccac ccagacatca   8460

acttgatctt ggctaccggt ggtccaggta tggttaaggc tgcttactct tctggtaagc   8520

cagctatcgg tgttggtgct ggtaacaccc cagttgttat cgacgaaacc gctgacatca   8580

agagagctgt tgcttctgtt ttgatgtcta agaccttcga caacggtgtt atctgtgctt   8640

ctgaacaatc tgttgttgtt gttgactctg tttacgacgc tgttagagaa agattcgcta   8700

cccacggtgg ttacttgttg caaggtaagg aattgaaggc tgttcaagac gttatcttga   8760

agaacggtgc tttgaacgct gctatcgttg gtcaaccagc ttacaagatc gctgaattag   8820

ctggtttctc tgttccagaa aacaccaaga tcttgatcgg tgaagttacc gttgttgacg   8880

aatctgaacc attcgctcac gaaaagttgt ctccaacctt ggctatgtac agagctaagg   8940

acttcgaaga cgctgttgaa aaagctgaaa agttggttgc tatgggtggt attggtcaca   9000

cctcttgttt gtacaccgac caagacaacc aaccagctag agtttcttac ttcggtcaaa   9060

agatgaagac cgctagaatc ttgatcaaca ccccagcttc tcaaggtggt atcggtgact   9120

tgtacaactt caagttggct ccatctttga ccttgggttg tggttcttgg ggtggtaact   9180

ctatctctga aaacgttggt ccaaagcact tgatcaacaa gaagaccgtt gctaagagag   9240

ctgaaaacat gttgtggcac aagttgccaa aatctatcta cttcagaaga ggttctttgc   9300

caatcgcttt ggacgaagtt atcaccgacg gtcacaagag agctttgatc gttaccgaca   9360

gattcttgtt caacaacggt tacgctgacc aaatcacctc tgttttgaag gctgctggtg   9420

ttgaaaccga agttttcttc gaagttgaag ctgacccaac cttgtctatc gttagaaagg   9480

gtgctgaatt ggctaactct ttcaagccag acgttatcat cgctttgggt ggtggttctc   9540

caatggacgc tgctaagatc atgtgggtta tgtacgaaca cccagaaacc cacttcgaag   9600

aattggcttt gagattcatg gacatcagaa agagaatcta caagttccca aagatgggtg   9660

ttaaggctaa gatgatcgct gttaccacca cctctggtac cggttctgaa gttaccccat   9720

tcgctgttgt taccgacgac gctaccggtc aaaagtaccc attggctgac tacgctttga   9780

ccccagacat ggctatcgtt gacgctaact tggttatgga catgccaaag tctttgtgtg   9840

ctttcggtgg tttggacgct gttacccacg ctatggaagc ttacgtttct gttttggctt   9900

ctgaattctc tgacggtcaa gctttgcaag ctttgaagtt gttgaaggaa tacttgccag   9960

cttcttacca cgaaggttct aagaacccag ttgctagaga aagagttcac tctgctgcta  10020

ccatcgctgg tatcgctttc gctaacgctt tcttgggtgt ttgtcactct atggctcaca  10080

agttgggttc tcaattccac atcccacacg gtttggctaa cgctttgttg atctgtaacg  10140

ttatcagata caacgctaac gacaacccaa ccaagcaaac cgctttctct caatacgaca  10200

gaccacaagc tagaagaaga tacgctgaaa tcgctgacca cttgggtttg tctgctccag  10260

gtgacagaac cgctgcaaag atcgaaaagt tgttggcttg gttggaaacc ttgaaggctg  10320

aattgggtat cccaaagtct atcagagaag ctggtgttca agaagctgac ttcttggcta  10380

acgttgacaa gttgtctgaa gacgctttcg acgaccaatg taccggtgct aacccaagat  10440

acccattgat ctctgaattg aagcaaatct tgttggacac ctactacggt agagactacg  10500

ttgaaggtga aaccgctgct aagaaggaag ctgctccagc taaggctgaa aagaaggcta  10560

agaagtctgc ttagcttaag cgcgcgaatt tcttatgatt tatgattttt attattaaat  10620

aagttataaa aaaaataagt gtatacaaat tttaaagtga ctcttaggtt ttaaaacgaa  10680

aattcttatt cttgagtaac tctttcctgt aggtcaggtt gctttctcag gtatagcatg  10740

aggtcgctct tattgaccac acctctaccg gcatgccgag caaatgcctg caaatcgctc  10800

cccatttcac ccaattgtag atatgctaac tccagcaatg agttgatgaa tctcggtgtg  10860

tattttatgt cctcagagga caacacctgt tgtaatcgtt cttccacacg tacgaagctt  10920

aaaagggcga attctgcaga tatccatcac actggcggcc gcatgctagc tccggattat  10980

cgatgataag ctgtcaaaga tgagaattaa ttccacggac tatagactat actagatact  11040

ccgtctactg tacgatacac ttccgctcag gtccttgtcc tttaacgagg ccttaccact  11100

cttttgttac tctattgatc cagctcagca aaggcagtgt gatctaagat tctatcttcg  11160

cgatgtagta aaactagcta gaccgagaaa gagactagaa atgcaaaagg cacttctaca  11220

atggctgcca tcattattat ccgatgtgac gctgcagctt ctcaatgata ttcgaatacg  11280

ctttgaggag atacagccta atatccgaca aactgtttta cagatttacg atcgtacttg  11340

ttacccatca ttgaattttg aacatccgaa cctgggagtt ttccctgaaa cagatagtat  11400

atttgaacct gtataataat atatagtcta gcgctttacg gaagacaatg tatgtatttc  11460

ggttcctgga gaaactattg catctattgc ataggtaatc ttgcacgtcg catccccggt  11520

tcattttctg cgtttccatc ttgcacttca atagcatatc tttgttaacg aagcatctgt  11580

gcttcatttt gtagaacaaa aatgcaacgc gagagcgcta atttttcaaa caaagaatct  11640

gagctgcatt tttacagaac agaaatgcaa cgcgaaagcg ctattttacc aacgaagaat  11700

ctgtgcttca tttttgtaaa acaaaaatgc aacgcgacga gagcgctaat ttttcaaaca  11760

aagaatctga gctgcatttt tacagaacag aaatgcaacg cgagagcgct attttaccaa  11820

caaagaatct atacttcttt tttgttctac aaaaatgcat cccgagagcg ctatttttct  11880

aacaaagcat cttagattac tttttttctc ctttgtgcgc tctataatgc agtctcttga  11940

taactttttg cactgtaggt ccgttaaggt tagaagaagg ctactttggt gtctattttc  12000

tcttccataa aaaaagcctg actccacttc ccgcgtttac tgattactag cgaagctgcg  12060

ggtgcatttt ttcaagataa aggcatcccc gattatattc tataccgatg tggattgcgc  12120

atactttgtg aacagaaagt gatagcgttg atgattcttc attggtcaga aaattatgaa  12180

cggtttcttc tattttgtct ctatatacta cgtataggaa atgtttacat tttcgtattg  12240

ttttcgattc actctatgaa tagttcttac tacaattttt ttgtctaaag agtaatacta  12300

gagataaaca taaaaaatgt agaggtcgag tttagatgca agttcaagga gcgaaaggtg  12360

gatgggtagg ttatataggg atatagcaca gagatatata gcaaagagat acttttgagc  12420

aatgtttgtg gaagcggtat tcgcaatgcc ggctttcccc gtcaagctct aaatcggggg  12480

ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag  12540

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg  12600

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc  12660

tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat  12720

gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttcc  12780

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata tgatccgtcg  12840

agttcaagag aaaaaaaaag aaaaagcaaa aagaaaaaag gaaagcgcgc ctcgttcaga  12900

atgacacgta tagaatgatg cattaccttg tcatcttcag tatcatactg ttcgtataca  12960

tacttactga cattcatagg tatacatata tacacatgta tatatatcgt atgctgcagc  13020

tttaaataat cggtgtcact acataagaac acctttggtg gagggaacat cgttggtacc  13080

attgggcgag gtggcttctc ttatggcaac cgcaagagcc ttgaacgcac tctcactacg  13140

gtgatgatca ttcttgcctc gcagacaatc aacgtggagg gtaattctgc tagcctctgc  13200

aaagctttca agaaaatgcg ggatcatctc gcaagagaga tctcctactt tctccctttg  13260

caaaccaagt tcgacaactg cgtacggcct gttcgaaaga tctaccaccg ctctggaaag  13320

tgcctcatcc aaaggcgcaa atcctgatcc aaaccttttt actccacgcg ccagtagggc  13380

ctctttaaaa gcttgaccga gagcaatccc gcagtcttca gtggtgtgat ggtcgtctat  13440

gtgtaagtca ccaatgcact caacgattag cgaccagccg gaatgcttgg ccagagcatg  13500

tatcatatgg tccagaaacc ctatacctgt gtggacgtta atcacttgcg attgtgtggc  13560

ctgttctgct actgcttctg cctctttttc tgggaagatc gagtgctcta tcgctagggg  13620

accacccttt aaagagatcg caatctgaat cttggtttca tttgtaatac gctttactag  13680

ggctttctgc tctgtcatct ttgccttcgt ttatcttgcc tgctcatttt ttagtatatt  13740

cttcgaagaa atcacattac tttatataat gtataattca ttatgtgata atgccaatcg  13800

ctaagaaaaa aaaagagtca tccgctaggt ggaaaaaaaa aaatgaaaat cattaccgag  13860

gcataaaaaa atatagagtg tactagagga ggccaagagt aatagaaaaa gaaaattgcg  13920

ggaaaggact gtgttatgac ttccctgact aatgccgtgt tcaaacgata cctggcagtg  13980

actcctagcg ctcaccaagc tcttaaaacg gaattatggt gcactctcag tacaatctgc  14040

tctgatgccg catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga  14100

cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc  14160

atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga                        14200


<210>  38
<211>  3042
<212>  DNA
<213>  Artificial

<220>
<223>  pRNDAK

<400>  38
ggatccacta gtaacggccg ccagtgtgct ggaattcgcc cttctcgagc ttaagacgcg     60

tttcttcttc agattccctc atggagaaag tgcggcagat gtatatgaca gagtcgccag    120

tttccaagag actttattca ggcacttcca tgataggcaa gagagaagac ccagagatgt    180

tgttgtccta gttacacatg gtatttattc cagagtattc ctgatgaaat ggtttagatg    240

gacatacgaa gagtttgaat cgtttaccaa tgttcctaac gggagcgtaa tggtgatgga    300

actggacgaa tccatcaata gatacgtcct gaggaccgtg ctacccaaat ggactgattg    360

tgagggagac ctaactacat agtgtttaaa gattacggat atttaactta cttagaataa    420

tgccattttt ttgagttata ataatcctac gttagtgtga gcgggattta aactgtgagg    480

accttaatac attcagacac ttctgcggta tcaccctact tattcccttc gagattatat    540

ctaggaaccc atcaggttgg tggaagatta cccgttctaa gacttttcag cttcctctat    600

tgatgttaca cctggacacc ccttttctgg catccagttt ttaatcttca gtggcatgtg    660

agattctccg aaattaatta aagcaatcac acaattctct cggataccac ctcggttgaa    720

actgacaggt ggtttgttac gcatgctaat gcaaaggagc ctatatacct ttggctcggc    780

tgctgtaaca gggaatataa agggcagcat aatttaggag tttagtgaac ttgcaacatt    840

tactattttc ccttcttacg taaatatttt tctttttaat tctaaatcaa tctttttcaa    900

ttttttgttt gtattctttt cttgcttaaa tctataacta caaaaaacac atacataaat    960

ctagaaaatg tccgctaaat cgtttgaagt cacagatcca gtcaattcaa gtctcaaagg   1020

gtttgccctt gctaacccct ccattacgct ggtccctgaa gaaaaaattc tcttcagaaa   1080

gaccgattcc gacaagatcg cattaatttc tggtggtggt agtggacatg aacctacaca   1140

cgccggtttc attggtaagg gtatgttgag tggcgccgtg gttggcgaaa tttttgcatc   1200

cccttcaaca aaacagattt taaatgcaat ccgtttagtc aatgaaaatg cgtctggcgt   1260

tttattgatt gtgaagaact acacaggtga tgttttgcat tttggtctgt ccgctgagag   1320

agcaagagcc ttgggtatta actgccgcgt tgctgtcata ggtgatgatg ttgcagttgg   1380

cagagaaaag ggtggtatgg ttggtagaag agcattggca ggtaccgttt tggttcataa   1440

gattgtaggt gccttcgcag aagaatattc tagtaagtat ggcttagacg gtacagctaa   1500

agtggctaaa attatcaacg acaatttggt gaccattgga tcttctttag accattgtaa   1560

agttcctggc aggaaattcg aaagtgaatt aaacgaaaaa caaatggaat tgggtatggg   1620

tattcataac gaacctggtg tgaaagtttt agaccctatt ccttctaccg aagacttgat   1680

ctccaagtat atgctaccaa aactattgga tccaaacgat aaggatagag cttttgtaaa   1740

gtttgatgaa gatgatgaag ttgtcttgtt agttaacaat ctcggcggtg tttctaattt   1800

tgttattagt tctatcactt ccaaaactac ggatttctta aaggaaaatt acaacataac   1860

cccggttcaa acaattgctg gcacattgat gacctccttc aatggtaatg ggttcagtat   1920

cacattacta aacgccacta aggctacaaa ggctttgcaa tctgattttg aggagatcaa   1980

atcagtacta gacttgttga acgcatttac gaacgcaccg ggctggccaa ttgcagattt   2040

tgaaaagact tctgccccat ctgttaacga tgacttgtta cataatgaag taacagcaaa   2100

ggccgtcggt acctatgact ttgacaagtt tgctgagtgg atgaagagtg gtgctgaaca   2160

agttatcaag agcgaaccgc acattacgga actagacaat caagttggtg atggtgattg   2220

tggttacact ttagtggcag gagttaaagg catcaccgaa aaccttgaca agctgtcgaa   2280

ggactcatta tctcaggcgg ttgcccaaat ttcagatttc attgaaggct caatgggagg   2340

tacttctggt ggtttatatt ctattctttt gtcgggtttt tcacacggat taattcaggt   2400

ttgtaaatca aaggatgaac ccgtcactaa ggaaattgtg gctaagtcac tcggaattgc   2460

attggatact ttatacaaat atacaaaggc aaggaaggga tcatccacca tgattgatgc   2520

tttagaacca ttcgttaaag aatttactgc atctaaggat ttcaataagg cggtaaaagc   2580

tgcagaggaa ggtgctaaat ccactgctac attcgaggcc aaatttggca gagcttcgta   2640

tgtcggcgat tcatctcaag tagaagatcc tggtgcagta ggcctatgtg agtttttgaa   2700

gggggttcaa agcgccttgt aagtcgagac aaatcgctct taaatatata cctaaagaac   2760

attaaagcta tattataagc aaagatacgt aaattttgct tatattatta tacacatatc   2820

atatttctat atttttaaga tttggttata taatgtacgt aatgcaaagg aaataaattt   2880

tatacattat tgaacagcgt ccaagtaact acattatgtg cactaatagt ttagcgtcgt   2940

gaagacttta ttgtgtcgcg aaaagtaaaa attttaaaaa ttagagcacc ttgaacttgc   3000

gaaaaaggtt ctcatcaact gtttaaaacg tacgaagctt aa                      3042


<210>  39
<211>  14291
<212>  DNA
<213>  Artificial

<220>
<223>  pRN977

<400>  39
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataagacgtc     60

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca    120

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa    180

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt    240

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca    300

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag    360

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc    420

ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca    480

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt    540

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct    600

gacaacgatc ggaggaccga aggagctaac cgcttttttt cacaacatgg gggatcatgt    660

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga    720

caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact    780

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc    840

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga    900

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt    960

agttatctac acgacgggca gtcaggcaac tatggatgaa cgaaatagac agatcgctga   1020

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact   1080

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga   1140

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt   1200

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca   1260

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct   1320

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta   1380

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct   1440

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc   1500

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca   1560

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga   1620

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg   1680

aacaggagag cgcacgaggg agcttccagg ggggaacgcc tggtatcttt atagtcctgt   1740

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggccgag   1800

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt   1860

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt   1920

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga   1980

ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta   2040

atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa   2100

tgtgagttac ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcctat   2160

gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta   2220

cgccaagctc ggaattaacc ctcactaaag ggaacaaaag ctgggtaccg ggccccccct   2280

cgaggtcgag cttaagacgc gtttcttctt cagattccct catggagaaa gtgcggcaga   2340

tgtatatgac agagtcgcca gtttccaaga gactttattc aggcacttcc atgataggca   2400

agagagaaga cccagagatg ttgttgtcct agttacacat ggtatttatt ccagagtatt   2460

cctgatgaaa tggtttagat ggacatacga agagtttgaa tcgtttacca atgttcctaa   2520

cgggagcgta atggtgatgg aactggacga atccatcaat agatacgtcc tgaggaccgt   2580

gctacccaaa tggactgatt gtgagggaga cctaactaca tagtgtttaa agattacgga   2640

tatttaactt acttagaata atgccatttt tttgagttat aataatccta cgttagtgtg   2700

agcgggattt aaactgtgag gaccttaata cattcagaca cttctgcggt atcaccctac   2760

ttattccctt cgagattata tctaggaacc catcaggttg gtggaagatt acccgttcta   2820

agacttttca gcttcctcta ttgatgttac acctggacac cccttttctg gcatccagtt   2880

tttaatcttc agtggcatgt gagattctcc gaaattaatt aaagcaatca cacaattctc   2940

tcggatacca cctcggttga aactgacagg tggtttgtta cgcatgctaa tgcaaaggag   3000

cctatatacc tttggctcgg ctgctgtaac agggaatata aagggcagca taatttagga   3060

gtttagtgaa cttgcaacat ttactatttt cccttcttac gtaaatattt ttctttttaa   3120

ttctaaatca atctttttca attttttgtt tgtattcttt tcttgcttaa atctataact   3180

acaaaaaaca catacataaa tctagaaaat gtccgctaaa tcgtttgaag tcacagatcc   3240

agtcaattca agtctcaaag ggtttgccct tgctaacccc tccattacgc tggtccctga   3300

agaaaaaatt ctcttcagaa agaccgattc cgacaagatc gcattaattt ctggtggtgg   3360

tagtggacat gaacctacac acgccggttt cattggtaag ggtatgttga gtggcgccgt   3420

ggttggcgaa atttttgcat ccccttcaac aaaacagatt ttaaatgcaa tccgtttagt   3480

caatgaaaat gcgtctggcg ttttattgat tgtgaagaac tacacaggtg atgttttgca   3540

ttttggtctg tccgctgaga gagcaagagc cttgggtatt aactgccgcg ttgctgtcat   3600

aggtgatgat gttgcagttg gcagagaaaa gggtggtatg gttggtagaa gagcattggc   3660

aggtaccgtt ttggttcata agattgtagg tgccttcgca gaagaatatt ctagtaagta   3720

tggcttagac ggtacagcta aagtggctaa aattatcaac gacaatttgg tgaccattgg   3780

atcttcttta gaccattgta aagttcctgg caggaaattc gaaagtgaat taaacgaaaa   3840

acaaatggaa ttgggtatgg gtattcataa cgaacctggt gtgaaagttt tagaccctat   3900

tccttctacc gaagacttga tctccaagta tatgctacca aaactattgg atccaaacga   3960

taaggataga gcttttgtaa agtttgatga agatgatgaa gttgtcttgt tagttaacaa   4020

tctcggcggt gtttctaatt ttgttattag ttctatcact tccaaaacta cggatttctt   4080

aaaggaaaat tacaacataa ccccggttca aacaattgct ggcacattga tgacctcctt   4140

caatggtaat gggttcagta tcacattact aaacgccact aaggctacaa aggctttgca   4200

atctgatttt gaggagatca aatcagtact agacttgttg aacgcattta cgaacgcacc   4260

gggctggcca attgcagatt ttgaaaagac ttctgcccca tctgttaacg atgacttgtt   4320

acataatgaa gtaacagcaa aggccgtcgg tacctatgac tttgacaagt ttgctgagtg   4380

gatgaagagt ggtgctgaac aagttatcaa gagcgaaccg cacattacgg aactagacaa   4440

tcaagttggt gatggtgatt gtggttacac tttagtggca ggagttaaag gcatcaccga   4500

aaaccttgac aagctgtcga aggactcatt atctcaggcg gttgcccaaa tttcagattt   4560

cattgaaggc tcaatgggag gtacttctgg tggtttatat tctattcttt tgtcgggttt   4620

ttcacacgga ttaattcagg tttgtaaatc aaaggatgaa cccgtcacta aggaaattgt   4680

ggctaagtca ctcggaattg cattggatac tttatacaaa tatacaaagg caaggaaggg   4740

atcatccacc atgattgatg ctttagaacc attcgttaaa gaatttactg catctaagga   4800

tttcaataag gcggtaaaag ctgcagagga aggtgctaaa tccactgcta cattcgaggc   4860

caaatttggc agagcttcgt atgtcggcga ttcatctcaa gtagaagatc ctggtgcagt   4920

aggcctatgt gagtttttga agggggttca aagcgccttg taagtcgaga caaatcgctc   4980

ttaaatatat acctaaagaa cattaaagct atattataag caaagatacg taaattttgc   5040

ttatattatt atacacatat catatttcta tatttttaag atttggttat ataatgtacg   5100

taatgcaaag gaaataaatt ttatacatta ttgaacagcg tccaagtaac tacattatgt   5160

gcactaatag tttagcgtcg tgaagacttt attgtgtcgc gaaaagtaaa aattttaaaa   5220

attagagcac cttgaacttg cgaaaaaggt tctcatcaac tgtttaaaac gtacgcctag   5280

gaagccttcg agcgtcccaa aaccttctca agcaaggttt tcagtataat gttacatgcg   5340

tacacgcgtt tgtacagaaa aaaaagaaaa atttgaaata taaataacgt tcttaatact   5400

aacataacta ttaaaaaaaa taaataggga cctagacttc aggttgtcta actccttcct   5460

tttcggttag agcggatgtg ggaggagggc gtgaatgtaa gcgtgacata actaattaca   5520

tgatatcgac aaaggaaaag gggcgcgcct tattcccatt cttgtaggaa tctttgaccg   5580

tattggtcag caaccaacaa agcagcgtaa acttggtctg gggtagcacc acctggcatg   5640

ttgtggatgg tttcaccttc agcacaagca gcttcagcaa cgattctcat cttagctgga   5700

acgtcttcct tgatgtccaa ttgagccaag gtgattggca aaccaacagc gtgagacaaa   5760

gcagcaacgg tttcgatttc ttcaactgga gcgttttcca aaaccaattg ggtcaaggta   5820

ccgaaagcaa ccttttcacc gtggtagtag tggtgagcgt ctgggatagc ggtcaaaccg   5880

ttgtgaacag cgtgagcagc agccaaacca ccagattcga aaccaacacc agacaagtag   5940

gtgttagctt cgataactct ttccaaagct ggggtaacaa cgtgttgttc agcagccaac   6000

atagcctttt caccttcttc caacaaggtg ttgtaacaca attcagccaa agccaaagca   6060

gcttgggtac acttaccacc agccatggtg gtagcaccag atctagaaca agctctagct   6120

tcgaaccagg tagccaaagc gtcaccgata ccagctgcca acaatctagc tggagcacca   6180

gcaacgatct tggtgtcaac gataaccatg tttgggttgt ttggcaacaa caagtatctg   6240

tcgaattcac cttcgtcggt gtagataaca gacaaagcag aacatggagc gtcggtagaa   6300

gcgatggttg gagcgatagc aactggaaca cccatgaagt gagccaaagc cttagcggtg   6360

tccaaggtct taccaccacc gatacccaag atagcaccac attgagcggt ttcagcgata   6420

cctctcaatc tgtcgatttc gttttgagaa cattcaccac cgaatggagc gatttcaaca   6480

accaaaccag cgtccttgaa agacttttca acggtagatt gagcgaaacc caaaacgaac   6540

ttgtcaccaa caaccaacca tctttcagcc aatggcttca agtattcacc caatctgttg   6600

ataacgtcag caccttggat gtacttacct ggagattgga tgattctgtc cattttctgc   6660

agttaattca gtaaattttc gatcttggga agaaaaaagc agtaagcgtg aaaaatctaa   6720

aagctgatgt agtagaagat cctattcttt aacaaagatt gaccttttct ttttcttctt   6780

ggtttgagta gaaaggggaa ggaagaatac aagagagagg aaaaaaagga agataaaaag   6840

agagcgtgat ataaatgaat atatattaaa caagagagat tgggaaggaa aggatcaaac   6900

aaacccaaaa atatttcaaa aaggagagag agaggcgagt ttggtttcaa aacggtttat   6960

ttatttatgc aagaggacgt ggaagaaaaa gaagaaggaa gaaaaaaatt tgaaagaaaa   7020

aaacgcgtgg cgggtaaaga agaaaatgga aaatagaggc cgggtgacag agaaatattg   7080

agggttaatt ggaaaatatg ttagggtgag gcatatgttt ttaagggttt tgaggatccg   7140

ataaggaaga atgtaggtta aatgttgtgc attaattgct gtggcagctt acccgcttcc   7200

ccacacattt actagtctcg agctcttcaa ctcaagacgc acagatatta taacatctgc   7260

ataataggca tttgcaagaa ttactcgtga gtaaggaaag agtgaggaac tatcgcatac   7320

ctgcatttaa agatgccgat ttgggcgcga atcctttatt ttggcttcac cctcatacta   7380

ttatcagggc cagaaaaagg aagtgtttcc ctccttcttg aattgatgtt accctcataa   7440

agcacgtggc ctcttatcga gaaagaaatt accgtcgctc gtgatttgtt tgcaaaaaga   7500

acaaaactga aaaaacccag acacgctcga cttcctgtct tcctattgat tgcagcttcc   7560

aatttcgtca cacaacaagg tcctagcgac ggctcacagg ttttgtaaca agcaatcgaa   7620

ggttctggaa tggcgggaaa gggtttagta ccacatgcta tgatgcccac tgtgatctcc   7680

agagcaaagt tcgttcgatc gtactgttac tctctctctt tcaaacagaa ttgtccgaat   7740

cgtgtgacaa caacagcctg ttctcacaca ctcttttctt ctaaccaagg gggtggttta   7800

gtttagtaga acctcgtgaa acttacattt acatatatat aaacttgcat aaattggtca   7860

atgcaagaaa tacatatttg gtcttttcta attcgtagtt tttcaagttc ttagatgctt   7920

tctttttctc ttttttacag atcatcaagg aagtaattat ctacttttta caacaaatat   7980

atctagaaaa tggctgttac caacgttgct gaattgaacg ctttggttga aagggttaag   8040

aaggctcaaa gagaatacgc ttctttcacc caagaacaag ttgacaagat cttcagagct   8100

gctgctttgg ctgctgctga cgctagaatc ccattggcta agatggctgt tgctgaatct   8160

ggtatgggta tcgttgaaga caaggttatc aagaaccact tcgcttctga atacatctac   8220

aacgcttaca aggacgaaaa gacctgtggt gttttgtcag aagacgacac cttcggtacc   8280

atcaccatcg ctgaaccaat cggtatcatc tgtggtatcg ttccaaccac caacccaacc   8340

tctaccgcta tcttcaagtc tttgatctct ttgaagacca gaaacgctat catcttctct   8400

ccacacccaa gagctaaaga cgctaccaac aaggctgctg acatcgtttt gcaagctgct   8460

atcgctgctg gtgctccaaa ggacttgatc ggttggatcg accaaccatc tgttgaattg   8520

tctaacgctt tgatgcacca cccagacatc aacttgatct tggctaccgg tggtccaggt   8580

atggttaagg ctgcttactc ttctggtaag ccagctatcg gtgttggtgc tggtaacacc   8640

ccagttgtta tcgacgaaac cgctgacatc aagagagctg ttgcttctgt tttgatgtct   8700

aagaccttcg acaacggtgt tatctgtgct tctgaacaat ctgttgttgt tgttgactct   8760

gtttacgacg ctgttagaga aagattcgct acccacggtg gttacttgtt gcaaggtaag   8820

gaattgaagg ctgttcaaga cgttatcttg aagaacggtg ctttgaacgc tgctatcgtt   8880

ggtcaaccag cttacaagat cgctgaatta gctggtttct ctgttccaga aaacaccaag   8940

atcttgatcg gtgaagttac cgttgttgac gaatctgaac cattcgctca cgaaaagttg   9000

tctccaacct tggctatgta cagagctaag gacttcgaag acgctgttga aaaagctgaa   9060

aagttggttg ctatgggtgg tattggtcac acctcttgtt tgtacaccga ccaagacaac   9120

caaccagcta gagtttctta cttcggtcaa aagatgaaga ccgctagaat cttgatcaac   9180

accccagctt ctcaaggtgg tatcggtgac ttgtacaact tcaagttggc tccatctttg   9240

accttgggtt gtggttcttg gggtggtaac tctatctctg aaaacgttgg tccaaagcac   9300

ttgatcaaca agaagaccgt tgctaagaga gctgaaaaca tgttgtggca caagttgcca   9360

aaatctatct acttcagaag aggttctttg ccaatcgctt tggacgaagt tatcaccgac   9420

ggtcacaaga gagctttgat cgttaccgac agattcttgt tcaacaacgg ttacgctgac   9480

caaatcacct ctgttttgaa ggctgctggt gttgaaaccg aagttttctt cgaagttgaa   9540

gctgacccaa ccttgtctat cgttagaaag ggtgctgaat tggctaactc tttcaagcca   9600

gacgttatca tcgctttggg tggtggttct ccaatggacg ctgctaagat catgtgggtt   9660

atgtacgaac acccagaaac ccacttcgaa gaattggctt tgagattcat ggacatcaga   9720

aagagaatct acaagttccc aaagatgggt gttaaggcta agatgatcgc tgttaccacc   9780

acctctggta ccggttctga agttacccca ttcgctgttg ttaccgacga cgctaccggt   9840

caaaagtacc cattggctga ctacgctttg accccagaca tggctatcgt tgacgctaac   9900

ttggttatgg acatgccaaa gtctttgtgt gctttcggtg gtttggacgc tgttacccac   9960

gctatggaag cttacgtttc tgttttggct tctgaattct ctgacggtca agctttgcaa  10020

gctttgaagt tgttgaagga atacttgcca gcttcttacc acgaaggttc taagaaccca  10080

gttgctagag aaagagttca ctctgctgct accatcgctg gtatcgcttt cgctaacgct  10140

ttcttgggtg tttgtcactc tatggctcac aagttgggtt ctcaattcca catcccacac  10200

ggtttggcta acgctttgtt gatctgtaac gttatcagat acaacgctaa cgacaaccca  10260

accaagcaaa ccgctttctc tcaatacgac agaccacaag ctagaagaag atacgctgaa  10320

atcgctgacc acttgggttt gtctgctcca ggtgacagaa ccgctgcaaa gatcgaaaag  10380

ttgttggctt ggttggaaac cttgaaggct gaattgggta tcccaaagtc tatcagagaa  10440

gctggtgttc aagaagctga cttcttggct aacgttgaca agttgtctga agacgctttc  10500

gacgaccaat gtaccggtgc taacccaaga tacccattga tctctgaatt gaagcaaatc  10560

ttgttggaca cctactacgg tagagactac gttgaaggtg aaaccgctgc taagaaggaa  10620

gctgctccag ctaaggctga aaagaaggct aagaagtctg cttagcttaa gcgcgcgaat  10680

ttcttatgat ttatgatttt tattattaaa taagttataa aaaaaataag tgtatacaaa  10740

ttttaaagtg actcttaggt tttaaaacga aaattcttat tcttgagtaa ctctttcctg  10800

taggtcaggt tgctttctca ggtatagcat gaggtcgctc ttattgacca cacctctacc  10860

ggcatgccga gcaaatgcct gcaaatcgct ccccatttca cccaattgta gatatgctaa  10920

ctccagcaat gagttgatga atctcggtgt gtattttatg tcctcagagg acaacacctg  10980

ttgtaatcgt tcttccacac gtacgaagct taaaagggcg aattctgcag atatccatca  11040

cactggcggc cgcatgctag ctccggatta tcgatgataa gctgtcaaag atgagaatta  11100

attccacgga ctatagacta tactagatac tccgtctact gtacgataca cttccgctca  11160

ggtccttgtc ctttaacgag gccttaccac tcttttgtta ctctattgat ccagctcagc  11220

aaaggcagtg tgatctaaga ttctatcttc gcgatgtagt aaaactagct agaccgagaa  11280

agagactaga aatgcaaaag gcacttctac aatggctgcc atcattatta tccgatgtga  11340

cgctgcagct tctcaatgat attcgaatac gctttgagga gatacagcct aatatccgac  11400

aaactgtttt acagatttac gatcgtactt gttacccatc attgaatttt gaacatccga  11460

acctgggagt tttccctgaa acagatagta tatttgaacc tgtataataa tatatagtct  11520

agcgctttac ggaagacaat gtatgtattt cggttcctgg agaaactatt gcatctattg  11580

cataggtaat cttgcacgtc gcatccccgg ttcattttct gcgtttccat cttgcacttc  11640

aatagcatat ctttgttaac gaagcatctg tgcttcattt tgtagaacaa aaatgcaacg  11700

cgagagcgct aatttttcaa acaaagaatc tgagctgcat ttttacagaa cagaaatgca  11760

acgcgaaagc gctattttac caacgaagaa tctgtgcttc atttttgtaa aacaaaaatg  11820

caacgcgacg agagcgctaa tttttcaaac aaagaatctg agctgcattt ttacagaaca  11880

gaaatgcaac gcgagagcgc tattttacca acaaagaatc tatacttctt ttttgttcta  11940

caaaaatgca tcccgagagc gctatttttc taacaaagca tcttagatta ctttttttct  12000

cctttgtgcg ctctataatg cagtctcttg ataacttttt gcactgtagg tccgttaagg  12060

ttagaagaag gctactttgg tgtctatttt ctcttccata aaaaaagcct gactccactt  12120

cccgcgttta ctgattacta gcgaagctgc gggtgcattt tttcaagata aaggcatccc  12180

cgattatatt ctataccgat gtggattgcg catactttgt gaacagaaag tgatagcgtt  12240

gatgattctt cattggtcag aaaattatga acggtttctt ctattttgtc tctatatact  12300

acgtatagga aatgtttaca ttttcgtatt gttttcgatt cactctatga atagttctta  12360

ctacaatttt tttgtctaaa gagtaatact agagataaac ataaaaaatg tagaggtcga  12420

gtttagatgc aagttcaagg agcgaaaggt ggatgggtag gttatatagg gatatagcac  12480

agagatatat agcaaagaga tacttttgag caatgtttgt ggaagcggta ttcgcaatgc  12540

cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt  12600

acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc  12660

ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt  12720

gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat  12780

tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa  12840

ttttaacaaa atattaacgt ttacaatttc ctgatgcggt attttctcct tacgcatctg  12900

tgcggtattt cacaccgcat atgatccgtc gagttcaaga gaaaaaaaaa gaaaaagcaa  12960

aaagaaaaaa ggaaagcgcg cctcgttcag aatgacacgt atagaatgat gcattacctt  13020

gtcatcttca gtatcatact gttcgtatac atacttactg acattcatag gtatacatat  13080

atacacatgt atatatatcg tatgctgcag ctttaaataa tcggtgtcac tacataagaa  13140

cacctttggt ggagggaaca tcgttggtac cattgggcga ggtggcttct cttatggcaa  13200

ccgcaagagc cttgaacgca ctctcactac ggtgatgatc attcttgcct cgcagacaat  13260

caacgtggag ggtaattctg ctagcctctg caaagctttc aagaaaatgc gggatcatct  13320

cgcaagagag atctcctact ttctcccttt gcaaaccaag ttcgacaact gcgtacggcc  13380

tgttcgaaag atctaccacc gctctggaaa gtgcctcatc caaaggcgca aatcctgatc  13440

caaacctttt tactccacgc gccagtaggg cctctttaaa agcttgaccg agagcaatcc  13500

cgcagtcttc agtggtgtga tggtcgtcta tgtgtaagtc accaatgcac tcaacgatta  13560

gcgaccagcc ggaatgcttg gccagagcat gtatcatatg gtccagaaac cctatacctg  13620

tgtggacgtt aatcacttgc gattgtgtgg cctgttctgc tactgcttct gcctcttttt  13680

ctgggaagat cgagtgctct atcgctaggg gaccaccctt taaagagatc gcaatctgaa  13740

tcttggtttc atttgtaata cgctttacta gggctttctg ctctgtcatc tttgccttcg  13800

tttatcttgc ctgctcattt tttagtatat tcttcgaaga aatcacatta ctttatataa  13860

tgtataattc attatgtgat aatgccaatc gctaagaaaa aaaaagagtc atccgctagg  13920

tggaaaaaaa aaaatgaaaa tcattaccga ggcataaaaa aatatagagt gtactagagg  13980

aggccaagag taatagaaaa agaaaattgc gggaaaggac tgtgttatga cttccctgac  14040

taatgccgtg ttcaaacgat acctggcagt gactcctagc gctcaccaag ctcttaaaac  14100

ggaattatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg  14160

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta  14220

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc  14280

gaaacgcgcg a                                                       14291


<210>  40
<211>  4891
<212>  DNA
<213>  Artificial

<220>
<223>  pRN593

<400>  40
gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     60

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc    120

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga    180

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa    240

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt    300

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg    360

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc    420

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg    480

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag    540

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt    600

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt    660

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac    720

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac    780

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag    840

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa    900

tactcatact cttccttttt caattcagaa gaactcgtca agaaggcgat agaaggcgat    960

gcgctgcgaa tcgggagcgg cgataccgta aagcacgagg aagcggtcag cccattcgcc   1020

gccaagctct tcagcaatat cacgggtagc caacgctatg tcctgatagc ggtccgccac   1080

acccagccgg ccacagtcga tgaatccaga aaagcggcca ttttccacca tgatattcgg   1140

caagcaggca tcgccatggt accgagtggt gttgtaacca ccctcaaaaa atgcggaaga   1200

ggtgtacagc taatattata atggaaaatc cttttgctct ataggatttt ttttttaaaa   1260

tttaaatata catatttatt tatatttatt tggttactaa attttgtatt aatttaataa   1320

taataagtaa tttctaacgt gataaagtag ttatgagaaa tgacataatg ctaatttatg   1380

aatatgatat agaagagcct cgaaaaaagt gggggaaagt atgatatgtt atctttctcc   1440

aataaatcta atcttcatgt agatctaatt cttcaatcat gtccggcagg ttcttcattg   1500

ggtagttgtt gtaaacgatt tggtatacgg cttcaaataa tgggaagtct tcgacagagc   1560

cacatgtttc caaccattcg tgaacttctt tgcaggtaat taaaccttga gcggattggc   1620

cattcaacaa ctcgtacacc taggatccgt cgacactgga tggcggcgtt agtatcgaat   1680

cgacagcagt atagcgacca gcattcacat acgattgacg catgatatta ctttctgcgc   1740

acttaacttc gcatctgggc agatgatgtc gaggcgaaaa aaaatataaa tcacgctaac   1800

atttgattaa aatagaacaa ctacaatata aaaaaactat acaaatgaca agttcttgaa   1860

aacaagaatc tttttattgt cagtactgat tattcctttg ccctcggacg agtgctgggg   1920

cgtcggtttc cactatcggc gagtacttct acacagccat cggtccagac ggccgcgctt   1980

ctgcgggcga tttgtgtacg cccgacagtc ccggctccgg atcggacgat tgcgtcgcat   2040

cgaccctgcg cccaagctgc atcatcgaaa ttgccgtcaa ccaagctctg atagagttgg   2100

tcaagaccaa tgcggagcat atacgcccgg agccgcggcg atcctgcaag ctccggatgc   2160

ctccgctcga agtagcgcgt ctgctgctcc atacaagcca accacggcct ccagaagaag   2220

atgttggcga cctcgtattg ggaatccccg aacatcgcct cgctccagtc aatgaccgct   2280

gttatgcggc cattgtccgt caggacattg ttggagccga aatccgcgtg cacgaggtgc   2340

cggacttcgg ggcagtcctc ggcccaaagc atcagctcat cgagagcctg cgcgacggac   2400

gcactgacgg tgtcgtccat cacagtttgc cagtgataca catggggatc agcaatcgcg   2460

catatgaaat cacgccatgt agtgtattga ccgattcctt gcggtccgaa tgggccgaac   2520

ccgctcgtct ggctaagatc ggccgcagcg atcgcatcca tggcctccgc gaccggctgc   2580

agaacagcgg gcagttcggt ttcaggcagg tcttgcaacg tgacaccctg tgcacggcgg   2640

gagatgcaat aggtcaggct ctcgctgaat tccccaatgt caagcacttc cggaatcggg   2700

agcgcggccg atgcaaagtg ccgataaaca taacgatctt tgtagaaacc atcggcgcag   2760

ctatttaccc gcaggacata tccacgccct cctacatcga agctgaaagc acgagattct   2820

tcgccctccg agagctgcat caggtcggag acgctgtcga acttttcgat cagaaacttc   2880

tcgacagacg tcgcggtgag ttcaggcttt ttacccatgg ttgtttatgt tcggatgtga   2940

tgtgagaact gtatcctagc aagattttaa aaggaagtat atgaaagaag aacctcagtg   3000

gcaaatccta accttttata tttctctaca ggggcgcggc gtggggacaa ttcacgcgtc   3060

tgtgagggga gcgtttccct gctcgcaggt ctgcagcgag gagccgtaat ttttgcttcg   3120

cgccgtgcgg ccatcaaaat gtatggatgc aaatgattat acatggggat gtatgggcta   3180

aatgtacggg cgacagtcac atcatgcccc tgagctgcgc acgtcaagac tgtcaaggag   3240

ggtattctgg gcctccatgt cgctggccgg gtgacccggc ggggacgagg ccttaagttc   3300

gaacgtacga gctccggatt aagggcgaat tccagcacac tggcggccgt tactagacca   3360

gcattcaagt ggccggaagt taagtttaat ctatcagcag cagcagacat ctttatatta   3420

tcaatatttg tgtttgtgga gggggggggt gtacaatata caattgtttc ttgatgtctt   3480

atgtaggaga gtaagataaa agaaaattaa agggagaaag aatttaaggt aacgtaacag   3540

tttcactcat ggtagtatat atataactac gaaactgcca ataccaagcc agtctacgtg   3600

cgaattaggt tggatagatt tgatgaaccc attctgatac ttgttgtgcg gaaaaaggga   3660

caaaataggg aaaactggaa aaagaaaagg aaggggagag aagcaaggcg ggtaccaagc   3720

ttgatgcata gcttgagtat tctatagtgt cacctaaata gcttggcgta atcatggtca   3780

tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga   3840

agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg   3900

cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc   3960

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac   4020

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata   4080

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa   4140

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct   4200

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa   4260

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg   4320

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca   4380

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa   4440

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg   4500

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg   4560

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga   4620

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc   4680

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag   4740

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac   4800

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc   4860

ttcacctaga tccttttaaa ttaaaaatga a                                  4891


<210>  41
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Primer gpd1uf

<400>  41
aagcttggta cccgccttgc ttctctcccc                                      30


<210>  42
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Primer gpd1ur

<400>  42
tctagaccag cattcaagtg gccgga                                          26


<210>  43
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Primer gpd1df

<400>  43
cgtacgagtt gttgaatggc caatccgct                                       29


<210>  44
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Primer gpd1dr

<400>  44
ccatggtacc gagtggtgtt gtaaccaccc t                                    31


<210>  45
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer gpd1cf

<400>  45
accaatacgt aaacggggcg                                                 20


<210>  46
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer gpd1cr

<400>  46
aatacaccca tacatacgga cgc                                             23


<210>  47
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Primer acs1f

<400>  47
ttaagcttaa aatgtcgccc tctgccgt                                        28


<210>  48
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer acs1r

<400>  48
aagcgcgcta caacttgacc gaatcaatta gatgtctaac aatgccaggg                50


<210>  49
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Primer acs2f

<400>  49
aactgcagaa aatgacaatc aaggaacata aagtagttta tgaagctca                 49


<210>  50
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Primer acs2r

<400>  50
acgtcgacta tttctttttt tgagagaaaa attggttctc tacagcaga                 49


<210>  51
<211>  13018
<212>  DNA
<213>  Artificial

<220>
<223>  pRN753

<400>  51
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt     60

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt    120

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat    180

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt    240

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg    300

ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga    360

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc    420

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac    480

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg    540

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca    600

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttt cacaacatgg    660

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg    720

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg    780

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag    840

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg    900

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct    960

cccgtatcgt agttatctac acgacgggca gtcaggcaac tatggatgaa cgaaatagac   1020

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact   1080

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga   1140

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt   1200

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct   1260

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc   1320

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc   1380

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc   1440

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg   1500

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt   1560

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg   1620

agcattgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg   1680

gcagggtcgg aacaggagag cgcacgaggg agcttccagg ggggaacgcc tggtatcttt   1740

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag   1800

gggggccgag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt   1860

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta   1920

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt   1980

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc   2040

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca   2100

acgcaattaa tgtgagttac ctcactcatt aggcacccca ggctttacac tttatgcttc   2160

cggctcctat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg   2220

accatgatta cgccaagctc ggaattaacc ctcactaaag ggaacaaaag ctgggtaccg   2280

ggccccccct cgaccggtcc cacacaccat agcttcaaaa tgtttctact ccttttttac   2340

tcttccagat tttctcggac tccgcgcatc gccgtaccac ttcaaaacac ccaagcacag   2400

catactaaat ttcccctctt tcttcctcta gggtgtcgtt aattacccgt actaaaggtt   2460

tggaaaagaa aaaagagacc gcctcgtttc tttttcttcg tcgaaaaagg caataaaaat   2520

ttttatcacg tttctttttc ttgaaaattt ttttttttga tttttttctc tttcgatgac   2580

ctcccattga tatttaagtt aataaacggt cttcaatttc tcaagtttca gtttcatttt   2640

tcttgttcta ttacaacttt ttttacttct tgctcattag aaagaaagca tagcaatcta   2700

atctaagctg cagaagctta aaatgtcgcc ctctgccgta caatcatcaa aactagaaga   2760

acagtcaagt gaaattgaca agttgaaagc aaaaatgtcc cagtctgccg ccactgcgca   2820

gcagaagaag gaacatgagt atgaacattt gacttcggtc aagatcgtgc cacaacggcc   2880

catctcagat agactgcagc ccgcaattgc tacccactat tctccacact tggacgggtt   2940

gcaggactat cagcgcttgc acaaggagtc tattgaagac cctgctaagt tcttcggttc   3000

taaagctacc caatttttaa actggtctaa gccattcgat aaggtgttca tcccagaccc   3060

taaaacgggc aggccctcct tccagaacaa tgcatggttc ctcaacggcc aattaaacgc   3120

ctgttacaac tgtgttgaca gacatgcctt gaagactcct aacaagaaag ccattatttt   3180

cgaaggtgac gagcctggcc aaggctattc cattacctac aaggaactac ttgaagaagt   3240

ttgtcaagtg gcacaagtgc tgacttactc tatgggcgtt cgcaagggcg atactgttgc   3300

cgtgtacatg cctatggtcc cagaagcaat cataaccttg ttggccattt cccgtatcgg   3360

tgccattcac tccgtagtct ttgccgggtt ttcttccaac tccttgagag atcgtatcaa   3420

cgatggggac tctaaagttg tcatcactac agatgaatcc aacagaggtg gtaaagtcat   3480

tgagactaaa agaattgttg atgacgcgct aagagagacc ccaggcgtga gacacgtctt   3540

ggtttataga aagaccaaca atccatctgt tgctttccat gcccccagag atttggattg   3600

ggcaacagaa aagaagaaat acaagaccta ctatccatgc acacccgttg attctgagga   3660

tccattattc ttgttgtata cgtctggttc tactggtgcc cccaagggtg ttcaacattc   3720

taccgcaggt tacttgctgg gagctttgtt gaccatgcgc tacacttttg acactcacca   3780

agaagacgtt ttcttcacag ctggagacat tggctggatt acaggccaca cttatgtggt   3840

ttatggtccc ttactatatg gttgtgccac tttggtcttt gaagggactc ctgcgtaccc   3900

aaattactcc cgttattggg atattattga tgaacacaaa gtcacccaat tttatgttgc   3960

gccaactgct ttgcgtttgt tgaaaagagc tggtgattcc tacatcgaaa atcattcctt   4020

aaaatctttg cgttgcttgg gttcggtcgg tgagccaatt gctgctgaag tttgggagtg   4080

gtactctgaa aaaataggta aaaatgaaat ccccattgta gacacctact ggcaaacaga   4140

atctggttcg catctggtca ccccgctggc tggtggtgtt acaccaatga aaccgggttc   4200

tgcctcattc cccttcttcg gtattgatgc agttgttctt gaccctaaca ctggtgaaga   4260

acttaacacc agccacgcag agggtgtcct tgccgtcaaa gctgcatggc catcatttgc   4320

aagaactatt tggaaaaatc atgataggta tctagacact tatttgaacc cttaccctgg   4380

ctactatttc actggtgatg gtgctgcaaa ggataaggat ggttatatct ggattttggg   4440

tcgtgtagac gatgtggtga acgtctctgg tcaccgtctg tctaccgctg aaattgaggc   4500

tgctattatc gaagatccaa ttgtggccga gtgtgctgtt gtcggattca acgatgactt   4560

gactggtcaa gcagttgctg catttgtggt gttgaaaaac aaatctagtt ggtccaccgc   4620

aacagatgat gaattacaag atatcaagaa gcatttggtc tttactgtta gaaaagacat   4680

cgggccattt gccgcaccaa aattgatcat tttagtggat gacttgccca agacaagatc   4740

cggcaaaatt atgagacgta ttttaagaaa aatcctagca ggagaaagtg accaactagg   4800

cgacgtttct acattgtcaa accctggcat tgttagacat ctaattgatt cggtcaagtt   4860

gtaacttaag cgcgcgaatt tcttatgatt tatgattttt attattaaat aagttataaa   4920

aaaaataagt gtatacaaat tttaaagtga ctcttaggtt ttaaaacgaa aattcttatt   4980

cttgagtaac tctttcctgt aggtcaggtt gctttctcag gtatagcatg aggtcgctct   5040

tattgaccac acctctaccg gcatgccgag caaatgcctg caaatcgctc cccatttcac   5100

ccaattgtag atatgctaac tccagcaatg agttgatgaa tctcggtgtg tattttatgt   5160

cctcagagga caacacctgt tgtaatcgtt cttccacacg tacgttttaa acagttgatg   5220

agaacctttt tcgcaagttc aaggtgctct aatttttaaa atttttactt ttcgcgacac   5280

aataaagtct tcacgacgct aaactattag tgcacataat gtagttactt ggacgctgtt   5340

caataatgta taaaatttat ttcctttgca ttacgtacat tatataacca aatcttaaaa   5400

atatagaaat atgatatgtg tataataata taagcaaaat ttacgtatct ttgcttataa   5460

tatagcttta atgttcttta ggtatatatt taagagcgat ttgtctcgac tatttctttt   5520

tttgagagaa aaattggttc tctacagcag aaatgatggc aggtacaact tctgggttgg   5580

ccaaagtagt taggtcacct agctgttcgg cttcgttaga agcaaccttt cttagaactc   5640

ttctcataat ctttcctgac cttgttcttg gtagatctct aactagaata atggtttttg   5700

gtgaggcgaa aggaccaatc tcacccctaa cttgtaagat caattctcta cgtaaattat   5760

ctggtgtgat gtgttctgca tcaccttcag tagcgttgtt ttgtagataa ccatctttta   5820

gggaaacata tgcaacgacg gtttgaccgg tcaattcatc tggaataccg acaacagcag   5880

cttccgagac gttttcgtga tttgagatag atgcttcaat ttctgatgtg gataatctat   5940

gaccggaaac atttacaacg tcgtcaactc tacccctgat ccagtagtaa ccatcatgat   6000

ctctaccagc accatcacct gtgaaatagt gaccaggata aggtttcaag taagtatcca   6060

tgtaacggtc gtggtggttc caaacagatc tagccattga tggccatggt gatttaacgg   6120

caaggacacc ttcgacatca ttaccttcta attccacacc tgtaacaggg tcaatgatac   6180

aagcgttaat accaaagaat ggcacggtag cagaaccagg ttttgttggg acagcacctg   6240

ccaaaggagc aattaaatga gaaccagact ctgtttgcca catagtgtca caaatgacac   6300

agtttttgtt acccactttt tcatgatacc attcccataa gtctggagag attggttcac   6360

cgacggaacc caagacacgt aatgaggaag tgtcatattt ggcaatttcg gcttcaccta   6420

cacgtttgat taatcttaaa gcagttggag ccacatagaa atgggtagcc ttgtgacgtt   6480

ggataattct ccaatatcta ccataatctg ggtaggcagg agtggattcg aaaattattg   6540

aggcggtacc caaggttaat ggaccatata gagcataggt gtgacccgtg atccagccga   6600

cgtcaccggc agtgaagaga acatcttctg ggtgaatatc aaaaacgtat ctagttgtta   6660

aagcggcacc taataaataa ccacctgtag tgtgaacgac accctttgga gaaccagtgg   6720

aaccggaagt gtataataaa aatagaggat cttcagcgtc acatgaaaca ggaggtaggt   6780

aagttctctg cttagcggcc tcctcatgcc accagtaatc tctaccggcc ttcattggaa   6840

taccttcagt accagttctt tggaaaacca agatacggga aaccaaatcg actccgttca   6900

aaccttcgtc aacaattttt ttagtgttga tggtcttacc acctctttta ccttcatcac   6960

aagtgatgac cactttagaa ttagcgtcaa cgacacgatc tttcaacgaa ccagcggaga   7020

acccagcaaa gacaacagag tgaatagcac caatacgagc cacagccaac atagcaatga   7080

ccgcttctgg aatcattggc aaatagatag ccactgtgtc acctttctta acgccccagc   7140

tttttaagac accagcgatt tgggaaactt ttctgagtaa ttcaccaaat gtgatgattt   7200

tgttgtcgga ttcgtcatca gcttcataga tcaaagctgg cttgtcggga ttagcaaagg   7260

catgtctgtc aacacaattg tatgatgcat tcaatttacc gttcaaaaac catgcaacat   7320

caccattgtt caatgaacca gattgaactt tggtgtatgg agcatcccaa tgcaagtatt   7380

ccttagccat cttatcaaag aatttttctg gctcattgat agattgttga tacatttctt   7440

gataatgttg catatcagta acgtaaccct tgccgggttg gctgttgtaa aaatgttgag   7500

gagccttaag agcctttacg ttgtgagctt cataaactac tttatgttcc ttgattgtca   7560

ttttctgcag tctagatata tttgttgtaa aaagtagata attacttcct tgatgatctg   7620

taaaaaagag aaaaagaaag catctaagaa cttgaaaaac tacgaattag aaaagaccaa   7680

atatgtattt cttgcattga ccaatttatg caagtttata tatatgtaaa tgtaagtttc   7740

acgaggttct actaaactaa accaccccct tggttagaag aaaagagtgt gtgagaacag   7800

gctgttgttg tcacacgatt cggacaattc tgtttgaaag agagagagta acagtacgat   7860

cgaacgaact ttgctctgga gatcacagtg ggcatcatag catgtggtac taaacccttt   7920

cccgccattc cagaaccttc gattgcttgt tacaaaacct gtgagccgtc gctaggacct   7980

tgttgtgtga cgaaattgga agctgcaatc aataggaaga caggaagtcg agcgtgtctg   8040

ggttttttca gttttgttct ttttgcaaac aaatcacgag cgacggtaat ttctttctcg   8100

ataagaggcc acgtgcttta tgagggtaac atcaattcaa gaaggaggga aacacttcct   8160

ttttctggcc ctgataatag tatgagggtg aagccaaaat aaaggattcg cgcccaaatc   8220

ggcatcttta aatgcaggta tgcgatagtt cctcactctt tccttactca cgagtaattc   8280

ttgcaaatgc ctattatgca gatgttataa tatctgtgcg tcttgagttg aagagctcga   8340

gactagatgc atgctcgagc ggccgccagt gtgatggata tctgcagaat tcgccctttt   8400

gggccctgta cacctaggat ccgtcgacac tggatggcgg cgttagtatc gaatcgacag   8460

cagtatagcg accagcattc acatacgatt gacgcatgat attactttct gcgcacttaa   8520

cttcgcatct gggcagatga tgtcgaggcg aaaaaaaata taaatcacgc taacatttga   8580

ttaaaataga acaactacaa tataaaaaaa ctatacaaat gacaagttct tgaaaacaag   8640

aatcttttta ttgtcagtac tgattagaaa aactcatcga gcatcaaatg aaactgcaat   8700

ttattcatat caggattatc aataccatat ttttgaaaaa gccgtttctg taatgaagga   8760

gaaaactcac cgaggcagtt ccataggatg gcaagatcct ggtatcggtc tgcgattccg   8820

actcgtccaa catcaataca acctattaat ttcccctcgt caaaaataag gttatcaagt   8880

gagaaatcac catgagtgac gactgaatcc ggtgagaatg gcaaaagctt atgcatttct   8940

ttccagactt gttcaacagg ccagccatta cgctcgtcat caaaatcact cgcatcaacc   9000

aaaccgttat tcattcgtga ttgcgcctga gcgagacgaa atacgcgatc gctgttaaaa   9060

ggacaattac aaacaggaat cgaatgcaac cggcgcagga acactgccag cgcatcaaca   9120

atattttcac ctgaatcagg atattcttct aatacctgga atgctgtttt gccggggatc   9180

gcagtggtga gtaaccatgc atcatcagga gtacggataa aatgcttgat ggtcggaaga   9240

ggcataaatt ccgtcagcca gtttagtctg accatctcat ctgtaacatc attggcaacg   9300

ctacctttgc catgtttcag aaacaactct ggcgcatcgg gcttcccata caatcgatag   9360

attgtcgcac ctgattgccc gacattatcg cgagcccatt tatacccata taaatcagca   9420

tccatgttgg aatttaatcg cggcctcgaa acgtgagtct tttccttacc catggttgtt   9480

tatgttcgga tgtgatgtga gaactgtatc ctagcaagat tttaaaagga agtatatgaa   9540

agaagaacct cagtggcaaa tcctaacctt ttatatttct ctacaggggc gcggcgtggg   9600

gacaattcaa cgcgtctgtg aggggagcgt ttccctgctc gcaggtctgc agcgaggagc   9660

cgtaattttt gcttcgcgcc gtgcggccat caaaatgtat ggatgcaaat gattatacat   9720

ggggatgtat gggctaaatg tacgggcgac agtcacatca tgcccctgag ctgcgcacgt   9780

caagactgtc aaggagggta ttctgggcct ccatgtcgct ggccgggtga cccggcgggg   9840

acgaggcctt aagttcgaac gtacgagctc cggattatcg atgataagct gtcaaagatg   9900

agaattaatt ccacggacta tagactatac tagatactcc gtctactgta cgatacactt   9960

ccgctcaggt ccttgtcctt taacgaggcc ttaccactct tttgttactc tattgatcca  10020

gctcagcaaa ggcagtgtga tctaagattc tatcttcgcg atgtagtaaa actagctaga  10080

ccgagaaaga gactagaaat gcaaaaggca cttctacaat ggctgccatc attattatcc  10140

gatgtgacgc tgcagcttct caatgatatt cgaatacgct ttgaggagat acagcctaat  10200

atccgacaaa ctgttttaca gatttacgat cgtacttgtt acccatcatt gaattttgaa  10260

catccgaacc tgggagtttt ccctgaaaca gatagtatat ttgaacctgt ataataatat  10320

atagtctagc gctttacgga agacaatgta tgtatttcgg ttcctggaga aactattgca  10380

tctattgcat aggtaatctt gcacgtcgca tccccggttc attttctgcg tttccatctt  10440

gcacttcaat agcatatctt tgttaacgaa gcatctgtgc ttcattttgt agaacaaaaa  10500

tgcaacgcga gagcgctaat ttttcaaaca aagaatctga gctgcatttt tacagaacag  10560

aaatgcaacg cgaaagcgct attttaccaa cgaagaatct gtgcttcatt tttgtaaaac  10620

aaaaatgcaa cgcgacgaga gcgctaattt ttcaaacaaa gaatctgagc tgcattttta  10680

cagaacagaa atgcaacgcg agagcgctat tttaccaaca aagaatctat acttcttttt  10740

tgttctacaa aaatgcatcc cgagagcgct atttttctaa caaagcatct tagattactt  10800

tttttctcct ttgtgcgctc tataatgcag tctcttgata actttttgca ctgtaggtcc  10860

gttaaggtta gaagaaggct actttggtgt ctattttctc ttccataaaa aaagcctgac  10920

tccacttccc gcgtttactg attactagcg aagctgcggg tgcatttttt caagataaag  10980

gcatccccga ttatattcta taccgatgtg gattgcgcat actttgtgaa cagaaagtga  11040

tagcgttgat gattcttcat tggtcagaaa attatgaacg gtttcttcta ttttgtctct  11100

atatactacg tataggaaat gtttacattt tcgtattgtt ttcgattcac tctatgaata  11160

gttcttacta caattttttt gtctaaagag taatactaga gataaacata aaaaatgtag  11220

aggtcgagtt tagatgcaag ttcaaggagc gaaaggtgga tgggtaggtt atatagggat  11280

atagcacaga gatatatagc aaagagatac ttttgagcaa tgtttgtgga agcggtattc  11340

gcaatgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta  11400

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc  11460

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg  11520

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat  11580

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta  11640

acgcgaattt taacaaaata ttaacgttta caatttcctg atgcggtatt ttctccttac  11700

gcatctgtgc ggtatttcac accgcagggt aataactgat ataattaaat tgaagctcta  11760

atttgtgagt ttagtataca tgcatttact tataatacag ttttttagtt ttgctggccg  11820

catcttctca aatatgcttc ccagcctgct tttctgtaac gttcaccctc taccttagca  11880

tcccttccct ttgcaaatag tcctcttcca acaataataa tgtcagatcc tgtagagacc  11940

acatcatcca cggttctata ctgttgaccc aatgcgtctc ccttgtcatc taaacccaca  12000

ccgggtgtca taatcaacca atcgtaacct tcatctcttc cacccatgtc tctttgagca  12060

ataaagccga taacaaaatc tttgtcgctc ttcgcaatgt caacagtacc cttagtatat  12120

tctccagtag atagggagcc cttgcatgac aattctgcta acatcaaaag gcctctaggt  12180

tcctttgtta cttcttctgc cgcctgcttc aaaccgctaa caatacctgg gcccaccaca  12240

ccgtgtgcat tcgtaatgtc tgcccattct gctattctgt atacacccgc agagtactgc  12300

aatttgactg tattaccaat gtcagcaaat tttctgtctt cgaagagtaa aaaattgtac  12360

ttggcggata atgcctttag cggcttaact gtgccctcca tggaaaaatc agtcaagata  12420

tccacatgtg tttttagtaa acaaattttg ggacctaatg cttcaactaa ctccagtaat  12480

tccttggtgg tacgaacatc caatgaagca cacaagtttg tttgcttttc gtgcatgata  12540

ttaaatagct tggcagcaac aggactagga tgagtagcag cacgttcctt atatgtagct  12600

ttcgacatga tttatcttcg tttcctgcag gtttttgttc tgtgcagttg ggttaagaat  12660

actgggcaat ttcatgtttc ttcaacacta catatgcgta tatataccaa tctaagtctg  12720

tgctccttcc ttcgttcttc cttctgttcg gagattaccg aatcaaaaaa atttcaaaga  12780

aaccgaaatc aaaaaaaaga ataaaaaaaa aatgatgaat tgaattgaaa agcgtggtgc  12840

actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca  12900

cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg  12960

accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcga    13018


