SEQUENCE LISTING

<110>   Novartis AG
	DOUCE, Gillian

<120>   Clostridium difficile toxin-based vaccine

<130>   PAT054763-WO-PCT

<140>   PCT/US2012/
<141>   2012-12-07

<150>   GB 1121149.7
<151>   2011-12-08

<150>   GB 1217321.7
<151>   2012-09-27

<160>   112

<170>   SeqWin2010, version 1.0

<210>   1
<211>   2710
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Clostridium difficile

<400>   1
Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr 
    50                  55                  60                  

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg 
    210                 215                 220                 

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met 
        275                 280                 285             

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser 
    290                 295                 300                 

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu 
    530                 535                 540                 

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr 
545                 550                 555                 560 

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser 
                565                 570                 575     

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser 
            580                 585                 590         

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile 
        595                 600                 605             

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser 
    610                 615                 620                 

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu 
625                 630                 635                 640 

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly 
                645                 650                 655     

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser 
            660                 665                 670         

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile 
        675                 680                 685             

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser 
    690                 695                 700                 

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser 
705                 710                 715                 720 

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser 
                725                 730                 735     

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
            740                 745                 750         

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu 
        755                 760                 765             

Ala Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser 
    770                 775                 780                 

Ile Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala 
785                 790                 795                 800 

Ser Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser 
                805                 810                 815     

Pro Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser 
            820                 825                 830         

Ser Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn 
        835                 840                 845             

Ile Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu 
    850                 855                 860                 

Glu Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu 
865                 870                 875                 880 

Asp Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser 
                885                 890                 895     

Thr Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr 
            900                 905                 910         

Val Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr 
        915                 920                 925             

Lys Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly 
    930                 935                 940                 

Asn Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr 
945                 950                 955                 960 

Leu Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn 
                965                 970                 975     

Lys Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr 
            980                 985                 990         

Ala Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln 
        995                 1000                1005            

Leu Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu 
    1010                1015                1020                

Pro Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly 
1025                1030                1035                1040

Ile Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro 
                1045                1050                1055    

Leu Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn 
            1060                1065                1070        

Met Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly 
        1075                1080                1085            

Ala Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly 
    1090                1095                1100                

Ile Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr 
1105                1110                1115                1120

Ser Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly 
                1125                1130                1135    

Pro Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu 
            1140                1145                1150        

Val Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr 
        1155                1160                1165            

Cys Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly 
    1170                1175                1180                

Asn Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro 
1185                1190                1195                1200

Ser Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp 
                1205                1210                1215    

Phe Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe 
            1220                1225                1230        

Trp Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp 
        1235                1240                1245            

Gly Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe 
    1250                1255                1260                

Tyr Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys 
1265                1270                1275                1280

Pro Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr 
                1285                1290                1295    

Arg Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys 
            1300                1305                1310        

Leu Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu 
        1315                1320                1325            

Ser Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu 
    1330                1335                1340                

Trp Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn 
1345                1350                1355                1360

Gly Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile 
                1365                1370                1375    

Asp Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe 
            1380                1385                1390        

Ser Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu 
        1395                1400                1405            

Leu Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys 
    1410                1415                1420                

Ser Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn 
1425                1430                1435                1440

Leu Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys 
                1445                1450                1455    

Asn Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly 
            1460                1465                1470        

Ala Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp 
        1475                1480                1485            

Ser Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn 
    1490                1495                1500                

Ser Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp 
1505                1510                1515                1520

Ile Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys 
                1525                1530                1535    

Ser Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val 
            1540                1545                1550        

Asn Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe 
        1555                1560                1565            

Val Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu 
    1570                1575                1580                

Phe Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile 
1585                1590                1595                1600

Asn Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu 
                1605                1610                1615    

Gly Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr 
            1620                1625                1630        

Phe Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly 
        1635                1640                1645            

Asn Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly 
    1650                1655                1660                

Glu Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly 
1665                1670                1675                1680

Ile Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr 
                1685                1690                1695    

Ser Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro 
            1700                1705                1710        

Glu Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile 
        1715                1720                1725            

Asn Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser 
    1730                1735                1740                

Asp Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu 
1745                1750                1755                1760

Gln Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe Asn 
                1765                1770                1775    

Lys Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu Gly Tyr 
            1780                1785                1790        

Ile Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu Leu Asp Arg 
        1795                1800                1805            

Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp 
    1810                1815                1820                

Glu Asp Ser Lys Leu Val Lys Gly Leu Ile Asn Ile Asn Asn Ser Leu 
1825                1830                1835                1840

Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr 
                1845                1850                1855    

Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu 
            1860                1865                1870        

Ile Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp 
        1875                1880                1885            

Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr 
    1890                1895                1900                

Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile 
1905                1910                1915                1920

Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe 
                1925                1930                1935    

Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu 
            1940                1945                1950        

Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln 
        1955                1960                1965            

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile 
    1970                1975                1980                

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr 
1985                1990                1995                2000

Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His 
                2005                2010                2015    

Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr 
            2020                2025                2030        

Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn 
        2035                2040                2045            

Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn 
    2050                2055                2060                

Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp 
2065                2070                2075                2080

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu 
                2085                2090                2095    

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
            2100                2105                2110        

Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys 
        2115                2120                2125            

Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr 
    2130                2135                2140                

Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
2145                2150                2155                2160

Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
                2165                2170                2175    

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn 
            2180                2185                2190        

Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser 
        2195                2200                2205            

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe 
    2210                2215                2220                

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn 
2225                2230                2235                2240

Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile 
                2245                2250                2255    

Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys 
            2260                2265                2270        

Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala 
        2275                2280                2285            

Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr 
    2290                2295                2300                

Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn 
2305                2310                2315                2320

Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
                2325                2330                2335    

Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile 
            2340                2345                2350        

Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr 
        2355                2360                2365            

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr 
    2370                2375                2380                

Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr 
2385                2390                2395                2400

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn 
                2405                2410                2415    

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu 
            2420                2425                2430        

Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys 
        2435                2440                2445            

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr 
    2450                2455                2460                

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val 
2465                2470                2475                2480

Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
                2485                2490                2495    

Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe 
            2500                2505                2510        

Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro 
        2515                2520                2525            

Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile 
    2530                2535                2540                

Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp 
2545                2550                2555                2560

Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val 
                2565                2570                2575    

Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly 
            2580                2585                2590        

Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn 
        2595                2600                2605            

Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr 
    2610                2615                2620                

Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile 
2625                2630                2635                2640

Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe 
                2645                2650                2655    

Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys 
            2660                2665                2670        

Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu 
        2675                2680                2685            

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys 
    2690                2695                2700                

Ala Pro Gly Ile Tyr Gly 
2705                2710

<210>   2
<211>   2366
<212>   PRT
<213>   Clostridium difficile

<400>   2
Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          

Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser Ile 
        755                 760                 765             

Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys Glu 
    770                 775                 780                 

Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr Leu 
785                 790                 795                 800 

Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu Glu 
                805                 810                 815     

Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn Ile 
            820                 825                 830         

Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu Thr 
        835                 840                 845             

Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu Ser 
    850                 855                 860                 

Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu Asp 
865                 870                 875                 880 

Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly Phe 
                885                 890                 895     

Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val Glu 
            900                 905                 910         

Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu Glu 
        915                 920                 925             

Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys Leu 
    930                 935                 940                 

Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu Asn 
945                 950                 955                 960 

Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys Glu 
                965                 970                 975     

Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala Gln 
            980                 985                 990         

Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val Val 
        995                 1000                1005            

Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro Thr 
    1010                1015                1020                

Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val Ser 
1025                1030                1035                1040

Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro Leu Leu 
                1045                1050                1055    

Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val Asn Leu Thr 
            1060                1065                1070        

Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly Ile Ala Ser Gly 
        1075                1080                1085            

Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser Ala Gly Ile Pro 
    1090                1095                1100                

Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp Lys Ala Thr Lys Val 
1105                1110                1115                1120

Val Asp Tyr Phe Lys His Val Ser Leu Val Glu Thr Glu Gly Val Phe 
                1125                1130                1135    

Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln Asp Asp Leu Val Ile 
            1140                1145                1150        

Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu Gly Lys Cys Glu 
        1155                1160                1165            

Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp Ile 
    1170                1175                1180                

Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His Leu 
1185                1190                1195                1200

Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu Ser 
                1205                1210                1215    

Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala Trp 
            1220                1225                1230        

Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly Thr 
        1235                1240                1245            

Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr Trp 
    1250                1255                1260                

Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys Pro 
1265                1270                1275                1280

Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn Thr Arg 
                1285                1290                1295    

Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg Glu Lys Leu 
            1300                1305                1310        

Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala Leu Ser Leu Ser 
        1315                1320                1325            

Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser Glu Ser Asp Val Trp 
    1330                1335                1340                

Ile Ile Asp Val Asp Asn Val Val Arg Asp Val Thr Ile Glu Ser Asp 
1345                1350                1355                1360

Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile Leu Ser Thr Leu Ser 
                1365                1370                1375    

Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His Glu Ile Asn Phe Ser 
            1380                1385                1390        

Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser Leu Thr Phe Ser Ile 
        1395                1400                1405            

Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp Leu Leu Ser Lys Ser 
    1410                1415                1420                

Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn Ser 
1425                1430                1435                1440

Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu Leu 
                1445                1450                1455    

Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu Asn 
            1460                1465                1470        

Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu Leu 
        1475                1480                1485            

Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys Pro 
    1490                1495                1500                

Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile Thr 
1505                1510                1515                1520

Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp Asp Ile 
                1525                1530                1535    

Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr Ile Lys Leu 
            1540                1545                1550        

Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu Ile Leu Lys Phe 
        1555                1560                1565            

Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp Ser Leu Met Ser Phe 
    1570                1575                1580                

Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val Asn Phe Leu Gln Ser 
1585                1590                1595                1600

Asn Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile Ile Ser Gly Thr Thr 
                1605                1610                1615    

Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Glu Asn Asp Asn Ile Gln 
            1620                1625                1630        

Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr Asn Tyr Thr Leu Tyr 
        1635                1640                1645            

Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu Asp 
    1650                1655                1660                

Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys Tyr 
1665                1670                1675                1680

Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro Asn 
                1685                1690                1695    

Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn Asn 
            1700                1705                1710        

Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu Lys 
        1715                1720                1725            

Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser Asn 
    1730                1735                1740                

Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys Val 
1745                1750                1755                1760

Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr Leu 
                1765                1770                1775    

Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro Val 
            1780                1785                1790        

Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly Leu 
        1795                1800                1805            

Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe Tyr 
    1810                1815                1820                

Ile Asn Asn Phe Gly Met Met Val Ser Gly Leu Ile Tyr Ile Asn Asp 
1825                1830                1835                1840

Ser Leu Tyr Tyr Phe Lys Pro Pro Val Asn Asn Leu Ile Thr Gly Phe 
                1845                1850                1855    

Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro Ile Asn Gly Gly 
            1860                1865                1870        

Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys Asn Tyr Tyr Phe 
        1875                1880                1885            

Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser Thr Glu Asp Gly 
    1890                1895                1900                

Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu Asn Leu Glu Gly 
1905                1910                1915                1920

Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp Glu Asn Ile Tyr 
                1925                1930                1935    

Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp Lys Glu Leu Asp 
            1940                1945                1950        

Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys Ala Phe Lys Gly 
        1955                1960                1965            

Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn Ser Asp Gly Val 
    1970                1975                1980                

Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys His Tyr Phe Asp 
1985                1990                1995                2000

Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile Asp Gly Lys His 
                2005                2010                2015    

Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly Val Phe Asn Thr 
            2020                2025                2030        

Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu Asp Leu Gly Asn 
        2035                2040                2045            

Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu Asn Phe Asn Asn 
    2050                2055                2060                

Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val Val Gly Trp Lys 
2065                2070                2075                2080

Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu 
                2085                2090                2095    

Ala Tyr Ile Gly Leu Ser Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn 
            2100                2105                2110        

Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile Asn Asp Lys Val 
        2115                2120                2125            

Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly Val Gln Asn Ile 
    2130                2135                2140                

Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile Val Gln Ile Gly 
2145                2150                2155                2160

Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr 
                2165                2170                2175    

Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr Ser Gly Leu Val 
            2180                2185                2190        

Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu 
        2195                2200                2205            

Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe 
    2210                2215                2220                

Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp 
2225                2230                2235                2240

Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg Thr Gly Leu Ile 
                2245                2250                2255    

Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln 
            2260                2265                2270        

Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp 
        2275                2280                2285            

Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr 
    2290                2295                2300                

Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile 
2305                2310                2315                2320

Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr 
                2325                2330                2335    

Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile Asp Gly Glu Glu 
            2340                2345                2350        

Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile Ser Glu 
        2355                2360                2365    

<210>   3
<211>   769
<212>   PRT
<213>   Clostridium difficile

<400>   3
Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr 
    50                  55                  60                  

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg 
    210                 215                 220                 

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met 
        275                 280                 285             

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser 
    290                 295                 300                 

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu 
    530                 535                 540                 

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr 
545                 550                 555                 560 

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser 
                565                 570                 575     

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser 
            580                 585                 590         

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile 
        595                 600                 605             

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser 
    610                 615                 620                 

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu 
625                 630                 635                 640 

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly 
                645                 650                 655     

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser 
            660                 665                 670         

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile 
        675                 680                 685             

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser 
    690                 695                 700                 

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser 
705                 710                 715                 720 

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser 
                725                 730                 735     

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
            740                 745                 750         

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu 
        755                 760                 765             

Ala 
    

<210>   4
<211>   541
<212>   PRT
<213>   Clostridium difficile

<400>   4
Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr 
    50                  55                  60                  

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg 
    210                 215                 220                 

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Tyr Leu Asp Val Asp Met 
        275                 280                 285             

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser 
    290                 295                 300                 

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser 
    530                 535                 540     

<210>   5
<211>   228
<212>   PRT
<213>   Clostridium difficile

<400>   5
Leu Ser Glu Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp 
1               5                   10                  15      

Lys Asn Tyr Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu 
            20                  25                  30          

Ala Gly Ser Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp 
        35                  40                  45              

Asp Ile Ser Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys 
    50                  55                  60                  

Asn Ser Ile Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr 
65                  70                  75                  80  

Phe Leu Ser Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg 
                85                  90                  95      

Ile Pro Glu Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile 
            100                 105                 110         

Gly His Gly Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser 
        115                 120                 125             

Val Asp Ser Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys 
    130                 135                 140                 

Leu Asp Ile Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn 
145                 150                 155                 160 

Met Phe Ser Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu 
                165                 170                 175     

Leu Leu Ser Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn 
            180                 185                 190         

Lys Asn Ser Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn 
        195                 200                 205             

Ser Glu Gly Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn 
    210                 215                 220                 

Lys Glu Glu Ala 
225             

<210>   6
<211>   1039
<212>   PRT
<213>   Clostridium difficile

<400>   6
Ile Met Ser Asp Leu Ser Ser Lys Glu Tyr Ile Phe Phe Asp Ser Ile 
1               5                   10                  15      

Asp Asn Lys Leu Lys Ala Lys Ser Lys Asn Ile Pro Gly Leu Ala Ser 
            20                  25                  30          

Ile Ser Glu Asp Ile Lys Thr Leu Leu Leu Asp Ala Ser Val Ser Pro 
        35                  40                  45              

Asp Thr Lys Phe Ile Leu Asn Asn Leu Lys Leu Asn Ile Glu Ser Ser 
    50                  55                  60                  

Ile Gly Asp Tyr Ile Tyr Tyr Glu Lys Leu Glu Pro Val Lys Asn Ile 
65                  70                  75                  80  

Ile His Asn Ser Ile Asp Asp Leu Ile Asp Glu Phe Asn Leu Leu Glu 
                85                  90                  95      

Asn Val Ser Asp Glu Leu Tyr Glu Leu Lys Lys Leu Asn Asn Leu Asp 
            100                 105                 110         

Glu Lys Tyr Leu Ile Ser Phe Glu Asp Ile Ser Lys Asn Asn Ser Thr 
        115                 120                 125             

Tyr Ser Val Arg Phe Ile Asn Lys Ser Asn Gly Glu Ser Val Tyr Val 
    130                 135                 140                 

Glu Thr Glu Lys Glu Ile Phe Ser Lys Tyr Ser Glu His Ile Thr Lys 
145                 150                 155                 160 

Glu Ile Ser Thr Ile Lys Asn Ser Ile Ile Thr Asp Val Asn Gly Asn 
                165                 170                 175     

Leu Leu Asp Asn Ile Gln Leu Asp His Thr Ser Gln Val Asn Thr Leu 
            180                 185                 190         

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Asp Tyr Ser Ser Asn Lys 
        195                 200                 205             

Asp Val Leu Asn Asp Leu Ser Thr Ser Val Lys Val Gln Leu Tyr Ala 
    210                 215                 220                 

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Tyr Asp Ser Ile Gln Leu 
225                 230                 235                 240 

Val Asn Leu Ile Ser Asn Ala Val Asn Asp Thr Ile Asn Val Leu Pro 
                245                 250                 255     

Thr Ile Thr Glu Gly Ile Pro Ile Val Ser Thr Ile Leu Asp Gly Ile 
            260                 265                 270         

Asn Leu Gly Ala Ala Ile Lys Glu Leu Leu Asp Glu His Asp Pro Leu 
        275                 280                 285             

Leu Lys Lys Glu Leu Glu Ala Lys Val Gly Val Leu Ala Ile Asn Met 
    290                 295                 300                 

Ser Leu Ser Ile Ala Ala Thr Val Ala Ser Ile Val Gly Ile Gly Ala 
305                 310                 315                 320 

Glu Val Thr Ile Phe Leu Leu Pro Ile Ala Gly Ile Ser Ala Gly Ile 
                325                 330                 335     

Pro Ser Leu Val Asn Asn Glu Leu Ile Leu His Asp Lys Ala Thr Ser 
            340                 345                 350         

Val Val Asn Tyr Phe Asn His Leu Ser Glu Ser Lys Lys Tyr Gly Pro 
        355                 360                 365             

Leu Lys Thr Glu Asp Asp Lys Ile Leu Val Pro Ile Asp Asp Leu Val 
    370                 375                 380                 

Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Lys Leu Gly Thr Cys 
385                 390                 395                 400 

Asn Ile Leu Ala Met Glu Gly Gly Ser Gly His Thr Val Thr Gly Asn 
                405                 410                 415     

Ile Asp His Phe Phe Ser Ser Pro Ser Ile Ser Ser His Ile Pro Ser 
            420                 425                 430         

Leu Ser Ile Tyr Ser Ala Ile Gly Ile Glu Thr Glu Asn Leu Asp Phe 
        435                 440                 445             

Ser Lys Lys Ile Met Met Leu Pro Asn Ala Pro Ser Arg Val Phe Trp 
    450                 455                 460                 

Trp Glu Thr Gly Ala Val Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly 
465                 470                 475                 480 

Thr Arg Leu Leu Asp Ser Ile Arg Asp Leu Tyr Pro Gly Lys Phe Tyr 
                485                 490                 495     

Trp Arg Phe Tyr Ala Phe Phe Asp Tyr Ala Ile Thr Thr Leu Lys Pro 
            500                 505                 510         

Val Tyr Glu Asp Thr Asn Ile Lys Ile Lys Leu Asp Lys Asp Thr Arg 
        515                 520                 525             

Asn Phe Ile Met Pro Thr Ile Thr Thr Asn Glu Ile Arg Asn Lys Leu 
    530                 535                 540                 

Ser Tyr Ser Phe Asp Gly Ala Gly Gly Thr Tyr Ser Leu Leu Leu Ser 
545                 550                 555                 560 

Ser Tyr Pro Ile Ser Thr Asn Ile Asn Leu Ser Lys Asp Asp Leu Trp 
                565                 570                 575     

Ile Phe Asn Ile Asp Asn Glu Val Arg Glu Ile Ser Ile Glu Asn Gly 
            580                 585                 590         

Thr Ile Lys Lys Gly Lys Leu Ile Lys Asp Val Leu Ser Lys Ile Asp 
        595                 600                 605             

Ile Asn Lys Asn Lys Leu Ile Ile Gly Asn Gln Thr Ile Asp Phe Ser 
    610                 615                 620                 

Gly Asp Ile Asp Asn Lys Asp Arg Tyr Ile Phe Leu Thr Cys Glu Leu 
625                 630                 635                 640 

Asp Asp Lys Ile Ser Leu Ile Ile Glu Ile Asn Leu Val Ala Lys Ser 
                645                 650                 655     

Tyr Ser Leu Leu Leu Ser Gly Asp Lys Asn Tyr Leu Ile Ser Asn Leu 
            660                 665                 670         

Ser Asn Ile Ile Glu Lys Ile Asn Thr Leu Gly Leu Asp Ser Lys Asn 
        675                 680                 685             

Ile Ala Tyr Asn Tyr Thr Asp Glu Ser Asn Asn Lys Tyr Phe Gly Ala 
    690                 695                 700                 

Ile Ser Lys Thr Ser Gln Lys Ser Ile Ile His Tyr Lys Lys Asp Ser 
705                 710                 715                 720 

Lys Asn Ile Leu Glu Phe Tyr Asn Asp Ser Thr Leu Glu Phe Asn Ser 
                725                 730                 735     

Lys Asp Phe Ile Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile 
            740                 745                 750         

Asn Thr Ile Thr Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser 
        755                 760                 765             

Ile Asp Phe Ser Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn 
    770                 775                 780                 

Gly Leu Tyr Leu Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val 
785                 790                 795                 800 

Lys Asn Ser Asp Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe 
                805                 810                 815     

Leu Asp Asn Ile Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn 
            820                 825                 830         

Phe Val Ile Asp Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly 
        835                 840                 845             

Tyr Val Glu Phe Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe 
    850                 855                 860                 

Gly Glu Trp Lys Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn 
865                 870                 875                 880 

Gly Arg Asn Val Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu 
                885                 890                 895     

Asp Ile Ser Thr Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile 
            900                 905                 910         

Asp Arg Tyr Ile Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser 
        915                 920                 925             

Leu Ile Asn Ile Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu 
    930                 935                 940                 

Ile Ile Val Leu Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn 
945                 950                 955                 960 

Leu Asp Ser Ser Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp 
                965                 970                 975     

Phe Ile Leu Val Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln 
            980                 985                 990         

Lys Ile Arg Ile Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe Asn Lys 
        995                 1000                1005            

Met Ser Ile Asp Phe Lys Asp Ile Lys Lys Leu Ser Leu Gly Tyr Ile 
    1010                1015                1020                

Met Ser Asn Phe Lys Ser Phe Asn Ser Glu Asn Glu Leu Asp Arg 
1025                1030                1035                

<210>   7
<211>   266
<212>   PRT
<213>   Clostridium difficile

<400>   7
Ala Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr 
1               5                   10                  15      

Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser 
            20                  25                  30          

Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu 
        35                  40                  45              

Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp 
    50                  55                  60                  

Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile 
65                  70                  75                  80  

Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp 
                85                  90                  95      

Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe 
            100                 105                 110         

Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys 
        115                 120                 125             

Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val 
    130                 135                 140                 

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr 
145                 150                 155                 160 

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile 
                165                 170                 175     

Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn Ile 
            180                 185                 190         

Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile Ile Val Leu 
        195                 200                 205             

Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn Leu Asp Ser Ser 
    210                 215                 220                 

Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp Phe Ile Leu Val 
225                 230                 235                 240 

Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile 
                245                 250                 255     

Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe 
            260                 265     

<210>   8
<211>   902
<212>   PRT
<213>   Clostridium difficile

<400>   8
Asp His Leu Gly Phe Lys Ile Ile Asp Asn Lys Thr Tyr Tyr Tyr Asp 
1               5                   10                  15      

Glu Asp Ser Lys Leu Val Lys Gly Leu Ile Asn Ile Asn Asn Ser Leu 
            20                  25                  30          

Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr 
        35                  40                  45              

Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu 
    50                  55                  60                  

Ile Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp 
65                  70                  75                  80  

Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr 
                85                  90                  95      

Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile 
            100                 105                 110         

Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe 
        115                 120                 125             

Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu 
    130                 135                 140                 

Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln 
145                 150                 155                 160 

Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile 
                165                 170                 175     

Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr 
            180                 185                 190         

Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His 
        195                 200                 205             

Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr 
    210                 215                 220                 

Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn 
225                 230                 235                 240 

Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn 
                245                 250                 255     

Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp 
            260                 265                 270         

Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu 
        275                 280                 285             

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
    290                 295                 300                 

Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys 
305                 310                 315                 320 

Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr 
                325                 330                 335     

Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
            340                 345                 350         

Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
        355                 360                 365             

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn 
    370                 375                 380                 

Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser 
385                 390                 395                 400 

Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe 
                405                 410                 415     

Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn 
            420                 425                 430         

Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile 
        435                 440                 445             

Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys 
    450                 455                 460                 

Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala 
465                 470                 475                 480 

Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr 
                485                 490                 495     

Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn 
            500                 505                 510         

Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
        515                 520                 525             

Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile 
    530                 535                 540                 

Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr 
545                 550                 555                 560 

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr 
                565                 570                 575     

Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr 
            580                 585                 590         

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn 
        595                 600                 605             

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu 
    610                 615                 620                 

Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys 
625                 630                 635                 640 

Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr 
                645                 650                 655     

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val 
            660                 665                 670         

Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
        675                 680                 685             

Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe 
    690                 695                 700                 

Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro 
705                 710                 715                 720 

Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile 
                725                 730                 735     

Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp 
            740                 745                 750         

Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val 
        755                 760                 765             

Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly 
    770                 775                 780                 

Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn 
785                 790                 795                 800 

Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr 
                805                 810                 815     

Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile 
            820                 825                 830         

Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe 
        835                 840                 845             

Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys 
    850                 855                 860                 

Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu 
865                 870                 875                 880 

Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys 
                885                 890                 895     

Ala Pro Gly Ile Tyr Gly 
            900         

<210>   9
<211>   204
<212>   PRT
<213>   Clostridium difficile

<400>   9
Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys 
1               5                   10                  15      

Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys 
            20                  25                  30          

Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
        35                  40                  45              

Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser 
    50                  55                  60                  

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser 
65                  70                  75                  80  

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe 
                85                  90                  95      

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
            100                 105                 110         

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp 
        115                 120                 125             

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile 
    130                 135                 140                 

Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn 
145                 150                 155                 160 

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
                165                 170                 175     

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln 
            180                 185                 190         

Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn 
        195                 200                 

<210>   10
<211>   457
<212>   PRT
<213>   Clostridium difficile

<400>   10
Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe 
1               5                   10                  15      

Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro 
            20                  25                  30          

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile 
        35                  40                  45              

Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly 
    50                  55                  60                  

Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln 
65                  70                  75                  80  

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala 
                85                  90                  95      

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu 
            100                 105                 110         

Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys 
        115                 120                 125             

Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser 
    130                 135                 140                 

Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile 
145                 150                 155                 160 

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
                165                 170                 175     

Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys 
            180                 185                 190         

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys 
        195                 200                 205             

Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
    210                 215                 220                 

Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys 
225                 230                 235                 240 

Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr 
                245                 250                 255     

Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
            260                 265                 270         

Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala 
        275                 280                 285             

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn 
    290                 295                 300                 

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser 
305                 310                 315                 320 

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe 
                325                 330                 335     

Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn 
            340                 345                 350         

Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys 
        355                 360                 365             

Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn 
    370                 375                 380                 

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu 
385                 390                 395                 400 

Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly 
                405                 410                 415     

Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala 
            420                 425                 430         

Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe 
        435                 440                 445             

Phe Gly Val Asp Gly Val Lys Ala Pro 
    450                 455         

<210>   11
<211>   320
<212>   PRT
<213>   Clostridium difficile

<400>   11
Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
1               5                   10                  15      

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
            20                  25                  30          

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln 
        35                  40                  45              

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
    50                  55                  60                  

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
65                  70                  75                  80  

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
                85                  90                  95      

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
            100                 105                 110         

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
        115                 120                 125             

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
    130                 135                 140                 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
145                 150                 155                 160 

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
                165                 170                 175     

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
            180                 185                 190         

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
        195                 200                 205             

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
    210                 215                 220                 

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
225                 230                 235                 240 

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
                245                 250                 255     

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
            260                 265                 270         

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
        275                 280                 285             

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
    290                 295                 300                 

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
305                 310                 315                 320 

<210>   12
<211>   864
<212>   PRT
<213>   Clostridium difficile

<400>   12
Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr Ile Asn 
1               5                   10                  15      

Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser 
            20                  25                  30          

Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val 
        35                  40                  45              

Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala 
    50                  55                  60                  

Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr 
65                  70                  75                  80  

Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn 
                85                  90                  95      

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr 
            100                 105                 110         

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile 
        115                 120                 125             

Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys 
    130                 135                 140                 

Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr 
145                 150                 155                 160 

Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr 
                165                 170                 175     

Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn 
            180                 185                 190         

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu 
        195                 200                 205             

Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys 
    210                 215                 220                 

Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr 
225                 230                 235                 240 

Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala 
                245                 250                 255     

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
            260                 265                 270         

Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
        275                 280                 285             

Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile 
    290                 295                 300                 

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly 
305                 310                 315                 320 

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr 
                325                 330                 335     

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe 
            340                 345                 350         

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala 
        355                 360                 365             

Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro 
    370                 375                 380                 

Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys 
385                 390                 395                 400 

Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile 
                405                 410                 415     

Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val 
            420                 425                 430         

Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
        435                 440                 445             

Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn 
    450                 455                 460                 

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser 
465                 470                 475                 480 

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe 
                485                 490                 495     

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
            500                 505                 510         

Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp 
        515                 520                 525             

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile 
    530                 535                 540                 

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
545                 550                 555                 560 

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
                565                 570                 575     

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln 
            580                 585                 590         

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
        595                 600                 605             

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
    610                 615                 620                 

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
625                 630                 635                 640 

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
                645                 650                 655     

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
            660                 665                 670         

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
        675                 680                 685             

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
    690                 695                 700                 

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
705                 710                 715                 720 

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
                725                 730                 735     

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
            740                 745                 750         

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
        755                 760                 765             

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
    770                 775                 780                 

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
785                 790                 795                 800 

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
                805                 810                 815     

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
            820                 825                 830         

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
        835                 840                 845             

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
    850                 855                 860                 

<210>   13
<211>   403
<212>   PRT
<213>   Clostridium difficile

<400>   13
Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp 
1               5                   10                  15      

Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys 
            20                  25                  30          

Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr 
        35                  40                  45              

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala 
    50                  55                  60                  

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
65                  70                  75                  80  

Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe 
                85                  90                  95      

Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro 
            100                 105                 110         

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile 
        115                 120                 125             

Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly 
    130                 135                 140                 

Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg 
145                 150                 155                 160 

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala 
                165                 170                 175     

Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr 
            180                 185                 190         

Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His 
        195                 200                 205             

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly 
    210                 215                 220                 

Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn 
225                 230                 235                 240 

Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His 
                245                 250                 255     

Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp 
            260                 265                 270         

Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met 
        275                 280                 285             

Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg 
    290                 295                 300                 

Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu 
305                 310                 315                 320 

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala 
                325                 330                 335     

Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr 
            340                 345                 350         

Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly 
        355                 360                 365             

Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly 
    370                 375                 380                 

Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val 
385                 390                 395                 400 

Lys Ala Pro 
            

<210>   14
<211>   872
<212>   PRT
<213>   Clostridium difficile

<400>   14
Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp 
1               5                   10                  15      

Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala 
            20                  25                  30          

Ala Leu Ile Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn 
        35                  40                  45              

Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe 
    50                  55                  60                  

Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln 
65                  70                  75                  80  

Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
                85                  90                  95      

Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn 
            100                 105                 110         

Asn Glu Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly 
        115                 120                 125             

Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala 
    130                 135                 140                 

Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe 
145                 150                 155                 160 

Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly 
                165                 170                 175     

Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe 
            180                 185                 190         

Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn 
        195                 200                 205             

Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr 
    210                 215                 220                 

Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr 
225                 230                 235                 240 

Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr 
                245                 250                 255     

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr 
            260                 265                 270         

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp 
        275                 280                 285             

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly 
    290                 295                 300                 

Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile 
305                 310                 315                 320 

Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala 
                325                 330                 335     

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr 
            340                 345                 350         

Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser 
        355                 360                 365             

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr 
    370                 375                 380                 

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile 
385                 390                 395                 400 

Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly 
                405                 410                 415     

Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu 
            420                 425                 430         

Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr 
        435                 440                 445             

Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile 
    450                 455                 460                 

Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe 
465                 470                 475                 480 

Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys 
                485                 490                 495     

Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln 
            500                 505                 510         

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala 
        515                 520                 525             

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr 
    530                 535                 540                 

Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His 
545                 550                 555                 560 

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly 
                565                 570                 575     

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn 
            580                 585                 590         

Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn 
        595                 600                 605             

Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu 
    610                 615                 620                 

Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val 
625                 630                 635                 640 

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn 
                645                 650                 655     

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys 
            660                 665                 670         

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys 
        675                 680                 685             

Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn 
    690                 695                 700                 

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu 
705                 710                 715                 720 

His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly 
                725                 730                 735     

Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala 
            740                 745                 750         

Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe 
        755                 760                 765             

Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe 
    770                 775                 780                 

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln 
785                 790                 795                 800 

Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr 
                805                 810                 815     

Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn 
            820                 825                 830         

Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly 
        835                 840                 845             

Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly 
    850                 855                 860                 

Val Lys Ala Pro Gly Ile Tyr Gly 
865                 870         

<210>   15
<211>   743
<212>   PRT
<213>   Clostridium difficile

<400>   15
Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro 
1               5                   10                  15      

Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg 
            20                  25                  30          

Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr 
        35                  40                  45              

Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile 
    50                  55                  60                  

Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
65                  70                  75                  80  

Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys 
                85                  90                  95      

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys 
            100                 105                 110         

Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn 
        115                 120                 125             

Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys 
    130                 135                 140                 

Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln 
145                 150                 155                 160 

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala 
                165                 170                 175     

Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr 
            180                 185                 190         

Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu 
        195                 200                 205             

Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala 
    210                 215                 220                 

Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr 
225                 230                 235                 240 

Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn 
                245                 250                 255     

Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu 
            260                 265                 270         

Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu 
        275                 280                 285             

Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala 
    290                 295                 300                 

Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly 
305                 310                 315                 320 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly 
                325                 330                 335     

Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys 
            340                 345                 350         

Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile 
        355                 360                 365             

Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr 
    370                 375                 380                 

Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr 
385                 390                 395                 400 

Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr 
                405                 410                 415     

Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn 
            420                 425                 430         

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val 
        435                 440                 445             

Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His 
    450                 455                 460                 

Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu 
465                 470                 475                 480 

Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val 
                485                 490                 495     

Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
            500                 505                 510         

Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr 
        515                 520                 525             

Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile 
    530                 535                 540                 

Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly 
545                 550                 555                 560 

Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr 
                565                 570                 575     

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe 
            580                 585                 590         

Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala 
        595                 600                 605             

Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro 
    610                 615                 620                 

Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn 
625                 630                 635                 640 

Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser 
                645                 650                 655     

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile 
            660                 665                 670         

Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly 
        675                 680                 685             

Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln 
    690                 695                 700                 

Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala 
705                 710                 715                 720 

Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly 
                725                 730                 735     

Val Asp Gly Val Lys Ala Pro 
            740             

<210>   16
<211>   816
<212>   PRT
<213>   Clostridium difficile

<400>   16
Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala 
1               5                   10                  15      

Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr 
            20                  25                  30          

Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn 
        35                  40                  45              

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr 
    50                  55                  60                  

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile 
65                  70                  75                  80  

Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys 
                85                  90                  95      

Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr 
            100                 105                 110         

Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr 
        115                 120                 125             

Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn 
    130                 135                 140                 

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu 
145                 150                 155                 160 

Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys 
                165                 170                 175     

Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr 
            180                 185                 190         

Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala 
        195                 200                 205             

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
    210                 215                 220                 

Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
225                 230                 235                 240 

Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile 
                245                 250                 255     

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly 
            260                 265                 270         

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr 
        275                 280                 285             

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe 
    290                 295                 300                 

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala 
305                 310                 315                 320 

Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro 
                325                 330                 335     

Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys 
            340                 345                 350         

Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile 
        355                 360                 365             

Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val 
    370                 375                 380                 

Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
385                 390                 395                 400 

Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn 
                405                 410                 415     

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser 
            420                 425                 430         

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe 
        435                 440                 445             

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
    450                 455                 460                 

Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp 
465                 470                 475                 480 

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile 
                485                 490                 495     

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
            500                 505                 510         

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
        515                 520                 525             

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln 
    530                 535                 540                 

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
545                 550                 555                 560 

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
                565                 570                 575     

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
            580                 585                 590         

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
        595                 600                 605             

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
    610                 615                 620                 

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
625                 630                 635                 640 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
                645                 650                 655     

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
            660                 665                 670         

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
        675                 680                 685             

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
    690                 695                 700                 

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
705                 710                 715                 720 

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
                725                 730                 735     

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
            740                 745                 750         

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
        755                 760                 765             

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
    770                 775                 780                 

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
785                 790                 795                 800 

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
                805                 810                 815     

<210>   17
<211>   767
<212>   PRT
<213>   Clostridium difficile

<400>   17
Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          

Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
    530                 535                 540                 

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
545                 550                 555                 560 

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
                565                 570                 575     

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr Glu 
            580                 585                 590         

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
        595                 600                 605             

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
    610                 615                 620                 

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
625                 630                 635                 640 

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys Asp 
                645                 650                 655     

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
            660                 665                 670         

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
        675                 680                 685             

Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr Ser 
    690                 695                 700                 

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
705                 710                 715                 720 

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
                725                 730                 735     

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
            740                 745                 750         

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser 
        755                 760                 765         

<210>   18
<211>   543
<212>   PRT
<213>   Clostridium difficile

<400>   18
Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
1               5                   10                  15      

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
            20                  25                  30          

Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
        35                  40                  45              

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
    50                  55                  60                  

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
65                  70                  75                  80  

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
                85                  90                  95      

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
            100                 105                 110         

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
        115                 120                 125             

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
    130                 135                 140                 

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
145                 150                 155                 160 

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
                165                 170                 175     

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
            180                 185                 190         

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
        195                 200                 205             

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
    210                 215                 220                 

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
225                 230                 235                 240 

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
                245                 250                 255     

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Asp Ile Leu 
            260                 265                 270         

Arg Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Tyr Leu Asp Val Asp 
        275                 280                 285             

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
    290                 295                 300                 

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
305                 310                 315                 320 

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
                325                 330                 335     

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
            340                 345                 350         

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
        355                 360                 365             

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
    370                 375                 380                 

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
385                 390                 395                 400 

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
                405                 410                 415     

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
            420                 425                 430         

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
        435                 440                 445             

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
    450                 455                 460                 

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
465                 470                 475                 480 

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
                485                 490                 495     

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
            500                 505                 510         

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
        515                 520                 525             

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu 
    530                 535                 540             

<210>   19
<211>   224
<212>   PRT
<213>   Clostridium difficile

<400>   19
Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys 
1               5                   10                  15      

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg 
            20                  25                  30          

Gly Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asp Lys Ile Ser Tyr 
        35                  40                  45              

Glu Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu 
    50                  55                  60                  

Phe Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro 
65                  70                  75                  80  

Gly Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile 
                85                  90                  95      

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly His Gly Lys 
            100                 105                 110         

Asp Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu 
        115                 120                 125             

Ser Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser 
    130                 135                 140                 

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Cys Asn Met Phe Ser Tyr 
145                 150                 155                 160 

Ser Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val 
                165                 170                 175     

Lys Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile 
            180                 185                 190         

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg 
        195                 200                 205             

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser 
    210                 215                 220                 

<210>   20
<211>   1066
<212>   PRT
<213>   Clostridium difficile

<400>   20
Ile Ile Lys Asp Ile Ser Ser Lys Glu Tyr Ile Ser Phe Asn Pro Lys 
1               5                   10                  15      

Glu Asn Lys Ile Thr Val Lys Ser Lys Asn Leu Pro Glu Leu Ser Thr 
            20                  25                  30          

Leu Leu Gln Glu Ile Arg Asn Asn Ser Asn Ser Ser Asp Ile Glu Leu 
        35                  40                  45              

Glu Glu Lys Val Met Leu Thr Glu Cys Glu Ile Asn Val Ile Ser Asn 
    50                  55                  60                  

Ile Asp Thr Gln Ile Val Glu Glu Arg Ile Glu Glu Ala Lys Asn Leu 
65                  70                  75                  80  

Thr Ser Asp Ser Ile Asn Tyr Ile Lys Asp Glu Phe Lys Leu Ile Glu 
                85                  90                  95      

Ser Ile Ser Asp Ala Leu Cys Asp Leu Lys Gln Gln Asn Glu Leu Glu 
            100                 105                 110         

Asp Ser His Phe Ile Ser Phe Glu Asp Ile Ser Glu Thr Asp Glu Gly 
        115                 120                 125             

Phe Ser Ile Arg Phe Ile Asn Lys Glu Thr Gly Glu Ser Ile Phe Val 
    130                 135                 140                 

Glu Thr Glu Lys Thr Ile Phe Ser Glu Tyr Ala Asn His Ile Thr Glu 
145                 150                 155                 160 

Glu Ile Ser Lys Ile Lys Gly Thr Ile Phe Asp Thr Val Asn Gly Lys 
                165                 170                 175     

Leu Val Lys Lys Val Asn Leu Asp Thr Thr His Glu Val Asn Thr Leu 
            180                 185                 190         

Asn Ala Ala Phe Phe Ile Gln Ser Leu Ile Glu Tyr Asn Ser Ser Lys 
        195                 200                 205             

Glu Ser Leu Ser Asn Leu Ser Val Ala Met Lys Val Gln Val Tyr Ala 
    210                 215                 220                 

Gln Leu Phe Ser Thr Gly Leu Asn Thr Ile Thr Asp Ala Ala Lys Val 
225                 230                 235                 240 

Val Glu Leu Val Ser Thr Ala Leu Asp Glu Thr Ile Asp Leu Leu Pro 
                245                 250                 255     

Thr Leu Ser Glu Gly Leu Pro Ile Ile Ala Thr Ile Ile Asp Gly Val 
            260                 265                 270         

Ser Leu Gly Ala Ala Ile Lys Glu Leu Ser Glu Thr Ser Asp Pro Leu 
        275                 280                 285             

Leu Arg Gln Glu Ile Glu Ala Lys Ile Gly Ile Met Ala Val Asn Leu 
    290                 295                 300                 

Thr Thr Ala Thr Thr Ala Ile Ile Thr Ser Ser Leu Gly Ile Ala Ser 
305                 310                 315                 320 

Gly Phe Ser Ile Leu Leu Val Pro Leu Ala Gly Ile Ser Ala Gly Ile 
                325                 330                 335     

Pro Ser Leu Val Asn Asn Glu Leu Val Leu Arg Asp Lys Ala Thr Lys 
            340                 345                 350         

Val Val Asp Tyr Phe Lys His Val Ser Leu Val Glu Thr Glu Gly Val 
        355                 360                 365             

Phe Thr Leu Leu Asp Asp Lys Ile Met Met Pro Gln Asp Asp Leu Val 
    370                 375                 380                 

Ile Ser Glu Ile Asp Phe Asn Asn Asn Ser Ile Val Leu Gly Lys Cys 
385                 390                 395                 400 

Glu Ile Trp Arg Met Glu Gly Gly Ser Gly His Thr Val Thr Asp Asp 
                405                 410                 415     

Ile Asp His Phe Phe Ser Ala Pro Ser Ile Thr Tyr Arg Glu Pro His 
            420                 425                 430         

Leu Ser Ile Tyr Asp Val Leu Glu Val Gln Lys Glu Glu Leu Asp Leu 
        435                 440                 445             

Ser Lys Asp Leu Met Val Leu Pro Asn Ala Pro Asn Arg Val Phe Ala 
    450                 455                 460                 

Trp Glu Thr Gly Trp Thr Pro Gly Leu Arg Ser Leu Glu Asn Asp Gly 
465                 470                 475                 480 

Thr Lys Leu Leu Asp Arg Ile Arg Asp Asn Tyr Glu Gly Glu Phe Tyr 
                485                 490                 495     

Trp Arg Tyr Phe Ala Phe Ile Ala Asp Ala Leu Ile Thr Thr Leu Lys 
            500                 505                 510         

Pro Arg Tyr Glu Asp Thr Asn Ile Arg Ile Asn Leu Asp Ser Asn Thr 
        515                 520                 525             

Arg Ser Phe Ile Val Pro Ile Ile Thr Thr Glu Tyr Ile Arg Glu Lys 
    530                 535                 540                 

Leu Ser Tyr Ser Phe Tyr Gly Ser Gly Gly Thr Tyr Ala Leu Ser Leu 
545                 550                 555                 560 

Ser Gln Tyr Asn Met Gly Ile Asn Ile Glu Leu Ser Glu Ser Asp Val 
                565                 570                 575     

Trp Ile Ile Asp Val Asp Asn Val Val Arg Asp Val Thr Ile Glu Ser 
            580                 585                 590         

Asp Lys Ile Lys Lys Gly Asp Leu Ile Glu Gly Ile Leu Ser Thr Leu 
        595                 600                 605             

Ser Ile Glu Glu Asn Lys Ile Ile Leu Asn Ser His Glu Ile Asn Phe 
    610                 615                 620                 

Ser Gly Glu Val Asn Gly Ser Asn Gly Phe Val Ser Leu Thr Phe Ser 
625                 630                 635                 640 

Ile Leu Glu Gly Ile Asn Ala Ile Ile Glu Val Asp Leu Leu Ser Lys 
                645                 650                 655     

Ser Tyr Lys Leu Leu Ile Ser Gly Glu Leu Lys Ile Leu Met Leu Asn 
            660                 665                 670         

Ser Asn His Ile Gln Gln Lys Ile Asp Tyr Ile Gly Phe Asn Ser Glu 
        675                 680                 685             

Leu Gln Lys Asn Ile Pro Tyr Ser Phe Val Asp Ser Glu Gly Lys Glu 
    690                 695                 700                 

Asn Gly Phe Ile Asn Gly Ser Thr Lys Glu Gly Leu Phe Val Ser Glu 
705                 710                 715                 720 

Leu Pro Asp Val Val Leu Ile Ser Lys Val Tyr Met Asp Asp Ser Lys 
                725                 730                 735     

Pro Ser Phe Gly Tyr Tyr Ser Asn Asn Leu Lys Asp Val Lys Val Ile 
            740                 745                 750         

Thr Lys Asp Asn Val Asn Ile Leu Thr Gly Tyr Tyr Leu Lys Asp Asp 
        755                 760                 765             

Ile Lys Ile Ser Leu Ser Leu Thr Leu Gln Asp Glu Lys Thr Ile Lys 
    770                 775                 780                 

Leu Asn Ser Val His Leu Asp Glu Ser Gly Val Ala Glu Ile Leu Lys 
785                 790                 795                 800 

Phe Met Asn Arg Lys Gly Asn Thr Asn Thr Ser Asp Ser Leu Met Ser 
                805                 810                 815     

Phe Leu Glu Ser Met Asn Ile Lys Ser Ile Phe Val Asn Phe Leu Gln 
            820                 825                 830         

Ser Asn Ile Lys Phe Ile Leu Asp Ala Asn Phe Ile Ile Ser Gly Thr 
        835                 840                 845             

Thr Ser Ile Gly Gln Phe Glu Phe Ile Cys Asp Glu Asn Asp Asn Ile 
    850                 855                 860                 

Gln Pro Tyr Phe Ile Lys Phe Asn Thr Leu Glu Thr Asn Tyr Thr Leu 
865                 870                 875                 880 

Tyr Val Gly Asn Arg Gln Asn Met Ile Val Glu Pro Asn Tyr Asp Leu 
                885                 890                 895     

Asp Asp Ser Gly Asp Ile Ser Ser Thr Val Ile Asn Phe Ser Gln Lys 
            900                 905                 910         

Tyr Leu Tyr Gly Ile Asp Ser Cys Val Asn Lys Val Val Ile Ser Pro 
        915                 920                 925             

Asn Ile Tyr Thr Asp Glu Ile Asn Ile Thr Pro Val Tyr Glu Thr Asn 
    930                 935                 940                 

Asn Thr Tyr Pro Glu Val Ile Val Leu Asp Ala Asn Tyr Ile Asn Glu 
945                 950                 955                 960 

Lys Ile Asn Val Asn Ile Asn Asp Leu Ser Ile Arg Tyr Val Trp Ser 
                965                 970                 975     

Asn Asp Gly Asn Asp Phe Ile Leu Met Ser Thr Ser Glu Glu Asn Lys 
            980                 985                 990         

Val Ser Gln Val Lys Ile Arg Phe Val Asn Val Phe Lys Asp Lys Thr 
        995                 1000                1005            

Leu Ala Asn Lys Leu Ser Phe Asn Phe Ser Asp Lys Gln Asp Val Pro 
    1010                1015                1020                

Val Ser Glu Ile Ile Leu Ser Phe Thr Pro Ser Tyr Tyr Glu Asp Gly 
1025                1030                1035                1040

Leu Ile Gly Tyr Asp Leu Gly Leu Val Ser Leu Tyr Asn Glu Lys Phe 
                1045                1050                1055    

Tyr Ile Asn Asn Phe Gly Met Met Val Ser 
            1060                1065    

<210>   21
<211>   514
<212>   PRT
<213>   Clostridium difficile

<400>   21
Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn Pro 
1               5                   10                  15      

Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp Lys 
            20                  25                  30          

Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe Ser 
        35                  40                  45              

Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp Glu 
    50                  55                  60                  

Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile Asp 
65                  70                  75                  80  

Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu Trp 
                85                  90                  95      

Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly Lys 
            100                 105                 110         

Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe Asn 
        115                 120                 125             

Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn Lys 
    130                 135                 140                 

His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu Ile 
145                 150                 155                 160 

Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile Gly 
                165                 170                 175     

Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn Glu 
            180                 185                 190         

Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile Leu 
        195                 200                 205             

Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala Val 
    210                 215                 220                 

Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp Glu 
225                 230                 235                 240 

Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asn Asp Gly Gln 
                245                 250                 255     

Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr Ile 
            260                 265                 270         

Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser Gly 
        275                 280                 285             

Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly Ile 
    290                 295                 300                 

Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala 
305                 310                 315                 320 

Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr 
                325                 330                 335     

Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr 
            340                 345                 350         

Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp 
        355                 360                 365             

Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn 
    370                 375                 380                 

Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg 
385                 390                 395                 400 

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn 
                405                 410                 415     

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr 
            420                 425                 430         

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp 
        435                 440                 445             

Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu 
    450                 455                 460                 

Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg 
465                 470                 475                 480 

Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile 
                485                 490                 495     

Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile 
            500                 505                 510         

Ser Glu 
        

<210>   22
<211>   210
<212>   PRT
<213>   Clostridium difficile

<400>   22
Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe Ala 
1               5                   10                  15      

Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu Tyr 
            20                  25                  30          

Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu Thr 
        35                  40                  45              

Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser Asp 
    50                  55                  60                  

Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile Asn 
65                  70                  75                  80  

Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met Arg 
                85                  90                  95      

Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu Asn 
            100                 105                 110         

Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe Tyr 
        115                 120                 125             

Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro Asp 
    130                 135                 140                 

Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe Glu 
145                 150                 155                 160 

Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys Arg 
                165                 170                 175     

Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile Ile 
            180                 185                 190         

Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val Ile 
        195                 200                 205             

Ser Glu 
    210 

<210>   23
<211>   311
<212>   PRT
<213>   Clostridium difficile

<400>   23
Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp 
1               5                   10                  15      

Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys 
            20                  25                  30          

Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu 
        35                  40                  45              

Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val 
    50                  55                  60                  

Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly 
65                  70                  75                  80  

Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile 
                85                  90                  95      

Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly 
            100                 105                 110         

Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly 
        115                 120                 125             

Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr 
    130                 135                 140                 

Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met 
145                 150                 155                 160 

Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala 
                165                 170                 175     

Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu 
            180                 185                 190         

Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr 
        195                 200                 205             

Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu 
    210                 215                 220                 

Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val 
225                 230                 235                 240 

Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu 
                245                 250                 255     

Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp 
            260                 265                 270         

Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr 
        275                 280                 285             

Gly Ser Val Ile Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr 
    290                 295                 300                 

Ala Gln Leu Val Ile Ser Glu 
305                 310     

<210>   24
<211>   872
<212>   PRT
<213>   Clostridium difficile

<400>   24
His Met Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val 
1               5                   10                  15      

Arg Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu 
            20                  25                  30          

Glu Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu 
        35                  40                  45              

Lys Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr 
    50                  55                  60                  

Lys Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu 
65                  70                  75                  80  

Val Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu 
                85                  90                  95      

Lys Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala 
            100                 105                 110         

Ile Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val 
        115                 120                 125             

Asn Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys 
    130                 135                 140                 

Thr Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu 
145                 150                 155                 160 

Asn Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg 
                165                 170                 175     

Met Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys 
            180                 185                 190         

Ala Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys 
        195                 200                 205             

Thr Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr 
    210                 215                 220                 

Tyr Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp 
225                 230                 235                 240 

Val Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr 
                245                 250                 255     

Glu Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile 
            260                 265                 270         

Leu Ala Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val 
        275                 280                 285             

Ala Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys 
    290                 295                 300                 

Pro Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala 
305                 310                 315                 320 

Ile Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe 
                325                 330                 335     

Asp Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala 
            340                 345                 350         

Ser Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu 
        355                 360                 365             

Ala Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile 
    370                 375                 380                 

Asn Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile 
385                 390                 395                 400 

Val Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn 
                405                 410                 415     

Pro Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe 
            420                 425                 430         

Ile Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met 
        435                 440                 445             

Met Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys 
    450                 455                 460                 

Thr Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln 
465                 470                 475                 480 

Asp Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu 
                485                 490                 495     

Ala Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser 
            500                 505                 510         

Thr Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala 
        515                 520                 525             

Lys Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu 
    530                 535                 540                 

Gly Ser Gly Gly Gly Gly Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly 
545                 550                 555                 560 

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe 
                565                 570                 575     

Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn 
            580                 585                 590         

Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr 
        595                 600                 605             

Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr 
    610                 615                 620                 

Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr 
625                 630                 635                 640 

Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr 
                645                 650                 655     

Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser 
            660                 665                 670         

Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val 
        675                 680                 685             

Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp 
    690                 695                 700                 

Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu 
705                 710                 715                 720 

Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala 
                725                 730                 735     

Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn 
            740                 745                 750         

Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe 
        755                 760                 765             

Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn 
    770                 775                 780                 

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu 
785                 790                 795                 800 

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys 
                805                 810                 815     

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr 
            820                 825                 830         

Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala 
        835                 840                 845             

Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val 
    850                 855                 860                 

Asp Gly Val Lys Ala Pro Leu Glu 
865                 870         

<210>   25
<211>   6
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Linker

<400>   25
Gly Ser Gly Gly Gly Gly 
1               5       

<210>   26
<211>   8
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Linker

<400>   26
Gly Ser Gly Ser Gly Gly Gly Gly 
1               5               

<210>   27
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Linker

<400>   27
Ala Ala Ala Leu Glu 
1               5   

<210>   28
<211>   26
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   IC-31

<400>   28
Ile Cys Ile Cys Ile Cys Ile Cys Ile Cys Ile Cys Ile Cys Ile Cys 
1               5                   10                  15      

Ile Cys Ile Cys Ile Cys Ile Cys Ile Cys 
            20                  25      

<210>   29
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Polycationic polymer

<400>   29
Lys Leu Lys Leu Leu Leu Leu Leu Lys Leu Lys 
1               5                   10      

<210>   30
<211>   8133
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Clostridium difficile

<400>   30
atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa  60
aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat  120
aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat  180
aaatataaaa cttcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa  240
gaagtaattc ttattaaaaa ttccaataca agccctgtag aaaaaaattt acattttgta  300
tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt  360
aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt aaatacacta  420
aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt  480
caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat  540
agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca  600
atagatgata ttataaagtc tcatctagta tctgaatata atagagatga aactgtatta  660
gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg  720
gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat  780
cgtggaaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc  840
ggagtatatt tagatgttga tatgcttcca ggtattcact ctgatttatt taaaacaata  900
tctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg  960
aagtataaaa aatatataaa taattataca tcagaaaact ttgataaact tgatcaacaa  1020
ttaaaagata attttaaact cattatagaa agtaaaagtg aaaaatctga gatattttct  1080
aaattagaaa atttaaatgt atctgatctt gaaattaaaa tagctttcgc tttaggcagt  1140
gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa  1200
caagtaaaaa atagatatca atttttaaac caacacctta acccagccat agagtctgat  1260
aataacttca cagatactac taaaattttt catgattcat tatttaattc agctaccgca  1320
gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa  1380
gctcgctcca caataagttt aagtggtcca ggagcttatg cgtcagctta ctatgatttc  1440
ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt  1500
aaattcccag aaaataatct atctcaattg acagaacaag aaataaatag tctatggagc  1560
tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga  1620
tctctttctg aagacaatgg ggtagacttt aataaaaata ctgccctcga caaaaactat  1680
ttattaaata ataaaattcc atcaaacaat gtagaagaag ctggaagtaa aaattatgtt  1740
cattatatca tacagttaca aggagatgat ataagttatg aagcaacatg caatttattt  1800
tctaaaaatc ctaaaaatag tattattata caacgaaata tgaatgaaag tgcaaaaagc  1860
tactttttaa gtgatgatgg agaatctatt ttagaattaa ataaatatag gatacctgaa  1920
agattaaaaa ataaggaaaa agtaaaagta acctttattg gacatggtaa agatgaattc  1980
aacacaagcg aatttgctag attaagtgta gattcacttt ccaatgagat aagttcattt  2040
ttagatacca taaaattaga tatatcacct aaaaatgtag aagtaaactt acttggatgt  2100
aatatgttta gttatgattt taatgttgaa gaaacttatc ctgggaagtt gctattaagt  2160
attatggaca aaattacttc cactttacct gatgtaaata aaaattctat tactatagga  2220
gcaaatcaat atgaagtaag aattaatagt gagggaagaa aagaacttct ggctcactca  2280
ggtaaatgga taaataaaga agaagctatt atgagcgatt tatctagtaa agaatacatt  2340
ttttttgatt ctatagataa taagctaaaa gcaaagtcca agaatattcc aggattagca  2400
tcaatatcag aagatataaa aacattatta cttgatgcaa gtgttagtcc tgatacaaaa  2460
tttattttaa ataatcttaa gcttaatatt gaatcttcta ttggtgatta catttattat  2520
gaaaaattag agcctgttaa aaatataatt cacaattcta tagatgattt aatagatgag  2580
ttcaatctac ttgaaaatgt atctgatgaa ttatatgaat taaaaaaatt aaataatcta  2640
gatgagaagt atttaatatc ttttgaagat atctcaaaaa ataattcaac ttactctgta  2700
agatttatta acaaaagtaa tggtgagtca gtttatgtag aaacagaaaa agaaattttt  2760
tcaaaatata gcgaacatat tacaaaagaa ataagtacta taaagaatag tataattaca  2820
gatgttaatg gtaatttatt ggataatata cagttagatc atacttctca agttaataca  2880
ttaaacgcag cattctttat tcaatcatta atagattata gtagcaataa agatgtactg  2940
aatgatttaa gtacctcagt taaggttcaa ctttatgctc aactatttag tacaggttta  3000
aatactatat atgactctat ccaattagta aatttaatat caaatgcagt aaatgatact  3060
ataaatgtac tacctacaat aacagagggg atacctattg tatctactat attagacgga  3120
ataaacttag gtgcagcaat taaggaatta ctagacgaac atgacccatt actaaaaaaa  3180
gaattagaag ctaaggtggg tgttttagca ataaatatgt cattatctat agctgcaact  3240
gtagcttcaa ttgttggaat aggtgctgaa gttactattt tcttattacc tatagctggt  3300
atatctgcag gaataccttc attagttaat aatgaattaa tattgcatga taaggcaact  3360
tcagtggtaa actattttaa tcatttgtct gaatctaaaa aatatggccc tcttaaaaca  3420
gaagatgata aaattttagt tcctattgat gatttagtaa tatcagaaat agattttaat  3480
aataattcga taaaactagg aacatgtaat atattagcaa tggagggggg atcaggacac  3540
acagtgactg gtaatataga tcactttttc tcatctccat ctataagttc tcatattcct  3600
tcattatcaa tttattctgc aataggtata gaaacagaaa atctagattt ttcaaaaaaa  3660
ataatgatgt tacctaatgc tccttcaaga gtgttttggt gggaaactgg agcagttcca  3720
ggtttaagat cattggaaaa tgacggaact agattacttg attcaataag agatttatac  3780
ccaggtaaat tttactggag attctatgct tttttcgatt atgcaataac tacattaaaa  3840
ccagtttatg aagacactaa tattaaaatt aaactagata aagatactag aaacttcata  3900
atgccaacta taactactaa cgaaattaga aacaaattat cttattcatt tgatggagca  3960
ggaggaactt actctttatt attatcttca tatccaatat caacgaatat aaatttatct  4020
aaagatgatt tatggatatt taatattgat aatgaagtaa gagaaatatc tatagaaaat  4080
ggtactatta aaaaaggaaa gttaataaaa gatgttttaa gtaaaattga tataaataaa  4140
aataaactta ttataggcaa tcaaacaata gatttttcag gcgatataga taataaagat  4200
agatatatat tcttgacttg tgagttagat gataaaatta gtttaataat agaaataaat  4260
cttgttgcaa aatcttatag tttgttattg tctggggata aaaattattt gatatccaat  4320
ttatctaata ttattgagaa aatcaatact ttaggcctag atagtaaaaa tatagcgtac  4380
aattacactg atgaatctaa taataaatat tttggagcta tatctaaaac aagtcaaaaa  4440
agcataatac attataaaaa agacagtaaa aatatattag aattttataa tgacagtaca  4500
ttagaattta acagtaaaga ttttattgct gaagatataa atgtatttat gaaagatgat  4560
attaatacta taacaggaaa atactatgtt gataataata ctgataaaag tatagatttc  4620
tctatttctt tagttagtaa aaatcaagta aaagtaaatg gattatattt aaatgaatcc  4680
gtatactcat cttaccttga ttttgtgaaa aattcagatg gacaccataa tacttctaat  4740
tttatgaatt tatttttgga caatataagt ttctggaaat tgtttgggtt tgaaaatata  4800
aattttgtaa tcgataaata ctttaccctt gttggtaaaa ctaatcttgg atatgtagaa  4860
tttatttgtg acaataataa aaatatagat atatattttg gtgaatggaa aacatcgtca  4920
tctaaaagca ctatatttag cggaaatggt agaaatgttg tagtagagcc tatatataat  4980
cctgatacgg gtgaagatat atctacttca ctagattttt cctatgaacc tctctatgga  5040
atagatagat atatcaataa agtattgata gcacctgatt tatatacaag tttaataaat  5100
attaatacca attattattc aaatgagtac taccctgaga ttatagttct taacccaaat  5160
acattccaca aaaaagtaaa tataaattta gatagttctt cttttgagta taaatggtct  5220
acagaaggaa gtgactttat tttagttaga tacttagaag aaagtaataa aaaaatatta  5280
caaaaaataa gaatcaaagg tatcttatct aatactcaat catttaataa aatgagtata  5340
gattttaaag atattaaaaa actatcatta ggatatataa tgagtaattt taaatcattt  5400
aattctgaaa atgaattaga tagagatcat ttaggattta aaataataga taataaaact  5460
tattactatg atgaagatag taaattagtt aaaggattaa tcaatataaa taattcatta  5520
ttctattttg atcctataga atttaactta gtaactggat ggcaaactat caatggtaaa  5580
aaatattatt ttgatataaa tactggagca gctttaatta gttataaaat tattaatggt  5640
aaacactttt attttaataa tgatggtgtg atgcagttgg gagtatttaa aggacctgat  5700
ggatttgaat attttgcacc tgccaatact caaaataata acatagaagg tcaggctata  5760
gtttatcaaa gtaaattctt aactttgaat ggcaaaaaat attattttga taatgactca  5820
aaagcagtca ctggatggag aattattaac aatgagaaat attactttaa tcctaataat  5880
gctattgctg cagtcggatt gcaagtaatt gacaataata agtattattt caatcctgac  5940
actgctatca tctcaaaagg ttggcagact gttaatggta gtagatacta ctttgatact  6000
gataccgcta ttgcctttaa tggttataaa actattgatg gtaaacactt ttattttgat  6060
agtgattgtg tagtgaaaat aggtgtgttt agtacctcta atggatttga atattttgca  6120
cctgctaata cttataataa taacatagaa ggtcaggcta tagtttatca aagtaaattc  6180
ttaactttga atggtaaaaa atattacttt gataataact caaaagcagt taccggatgg  6240
caaactattg atagtaaaaa atattacttt aatactaaca ctgctgaagc agctactgga  6300
tggcaaacta ttgatggtaa aaaatattac tttaatacta acactgctga agcagctact  6360
ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacactgc tatagcttca  6420
actggttata caattattaa tggtaaacat ttttatttta atactgatgg tattatgcag  6480
ataggagtgt ttaaaggacc taatggattt gaatattttg cacctgctaa tacggatgct  6540
aacaacatag aaggtcaagc tatactttac caaaatgaat tcttaacttt gaatggtaaa  6600
aaatattact ttggtagtga ctcaaaagca gttactggat ggagaattat taacaataag  6660
aaatattact ttaatcctaa taatgctatt gctgcaattc atctatgcac tataaataat  6720
gacaagtatt actttagtta tgatggaatt cttcaaaatg gatatattac tattgaaaga  6780
aataatttct attttgatgc taataatgaa tctaaaatgg taacaggagt atttaaagga  6840
cctaatggat ttgagtattt tgcacctgct aatactcaca ataataacat agaaggtcag  6900
gctatagttt accagaacaa attcttaact ttgaatggca aaaaatatta ttttgataat  6960
gactcaaaag cagttactgg atggcaaacc attgatggta aaaaatatta ctttaatctt  7020
aacactgctg aagcagctac tggatggcaa actattgatg gtaaaaaata ttactttaat  7080
cttaacactg ctgaagcagc tactggatgg caaactattg atggtaaaaa atattacttt  7140
aatactaaca ctttcatagc ctcaactggt tatacaagta ttaatggtaa acatttttat  7200
tttaatactg atggtattat gcagatagga gtgtttaaag gacctaatgg atttgaatac  7260
tttgcacctg ctaatactca taataataac atagaaggtc aagctatact ttaccaaaat  7320
aaattcttaa ctttgaatgg taaaaaatat tactttggta gtgactcaaa agcagttacc  7380
ggattgcgaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgttgcagtt  7440
actggatggc aaactattaa tggtaaaaaa tactacttta atactaacac ttctatagct  7500
tcaactggtt atacaattat tagtggtaaa catttttatt ttaatactga tggtattatg  7560
cagataggag tgtttaaagg acctgatgga tttgaatact ttgcacctgc taatacagat  7620
gctaacaata tagaaggtca agctatacgt tatcaaaata gattcctata tttacatgac  7680
aatatatatt attttggtaa taattcaaaa gcagctactg gttgggtaac tattgatggt  7740
aatagatatt acttcgagcc taatacagct atgggtgcga atggttataa aactattgat  7800
aataaaaatt tttactttag aaatggttta cctcagatag gagtgtttaa agggtctaat  7860
ggatttgaat actttgcacc tgctaatacg gatgctaaca atatagaagg tcaagctata  7920
cgttatcaaa atagattcct acatttactt ggaaaaatat attactttgg taataattca  7980
aaagcagtta ctggatggca aactattaat ggtaaagtat attactttat gcctgatact  8040
gctatggctg cagctggtgg acttttcgag attgatggtg ttatatattt ctttggtgtt  8100
gatggagtaa aagcccctgg gatatatggc taa                               8133

<210>   31
<211>   7101
<212>   DNA
<213>   Clostridium difficile

<400>   31
atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtactcaa  60
gaagatgaat atgttgcaat attggatgct ttagaagaat atcataatat gtcagagaat  120
actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tatttatata  180
gatacatata aaaaatctgg tagaaataaa gccttaaaaa aatttaagga atatctagtt  240
acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt  300
gtttggattg gaggtcaaat aaatgacact gctattaatt atataaatca atggaaagat  360
gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca  420
ttgaaaaaaa ctgtagtaga atcagcaata aatgatacac ttgaatcatt tagagaaaac  480
ttaaatgacc ctagatttga ctataataaa ttcttcagaa aacgtatgga aataatttat  540
gataaacaga aaaatttcat aaactactat aaagctcaaa gagaagaaaa tcctgaactt  600
ataattgatg atattgtaaa gacatatctt tcaaatgagt attcaaagga gatagatgaa  660
cttaatacct atattgaaga atccttaaat aaaattacac agaatagtgg aaatgatgtt  720
agaaactttg aagaatttaa aaatggagag tcattcaact tatatgaaca agagttggta  780
gaaaggtgga atttagctgc tgcttctgac atattaagaa tatctgcatt aaaagaaatt  840
ggtggtatgt atttagatgt tgatatgtta ccaggaatac aaccagactt atttgagtct  900
atagagaaac ctagttcagt aacagtggat ttttgggaaa tgacaaagtt agaagctata  960
atgaaataca aagaatatat accagaatat acctcagaac attttgacat gttagacgaa  1020
gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataaatc agaaatattc  1080
tcatcacttg gtgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaag  1140
ggtattataa atcaagggct aatttctgtg aaagactcat attgtagcaa tttaatagta  1200
aaacaaatcg agaatagata taaaatattg aataatagtt taaatccagc tattagcgag  1260
gataatgatt ttaatactac aacgaatacc tttattgata gtataatggc tgaagctaat  1320
gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca  1380
gatgttaaaa ctactattaa cttaagtggc cctgaagcat atgcggcagc ttatcaagat  1440
ttattaatgt ttaaagaagg cagtatgaat atccatttga tagaagctga tttaagaaac  1500
tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc tagcttatgg  1560
tcatttgacg atgcaagagc taaagctcaa tttgaagaat ataaaaggaa ttattttgaa  1620
ggttctcttg gtgaagatga taatcttgat ttttctcaaa atatagtagt tgacaaggag  1680
tatcttttag aaaaaatatc ttcattagca agaagttcag agagaggata tatacactat  1740
attgttcagt tacaaggaga taaaattagt tatgaagcag catgtaactt atttgcaaag  1800
actccttatg atagtgtact gtttcagaaa aatatagaag attcagaaat tgcatattat  1860
tataatcctg gagatggtga aatacaagaa atagacaagt ataaaattcc aagtataatt  1920
tctgatagac ctaagattaa attaacattt attggtcatg gtaaagatga atttaatact  1980
gatatatttg caggttttga tgtagattca ttatccacag aaatagaagc agcaatagat  2040
ttagctaaag aggatatttc tcctaagtca atagaaataa atttattagg atgtaatatg  2100
tttagctact ctatcaacgt agaggagact tatcctggaa aattattact taaagttaaa  2160
gataaaatat cagaattaat gccatctata agtcaagact ctattatagt aagtgcaaat  2220
caatatgaag ttagaataaa tagtgaagga agaagagaat tattggatca ttctggtgaa  2280
tggataaata aagaagaaag tattataaag gatatttcat caaaagaata tatatcattt  2340
aatcctaaag aaaataaaat tacagtaaaa tctaaaaatt tacctgagct atctacatta  2400
ttacaagaaa ttagaaataa ttctaattca agtgatattg aactagaaga aaaagtaatg  2460
ttaacagaat gtgagataaa tgttatttca aatatagata cgcaaattgt tgaggaaagg  2520
attgaagaag ctaagaattt aacttctgac tctattaatt atataaaaga tgaatttaaa  2580
ctaatagaat ctatttctga tgcactatgt gacttaaaac aacagaatga attagaagat  2640
tctcatttta tatcttttga ggacatatca gagactgatg agggatttag tataagattt  2700
attaataaag aaactggaga atctatattt gtagaaactg aaaaaacaat attctctgaa  2760
tatgctaatc atataactga agagatttct aagataaaag gtactatatt tgatactgta  2820
aatggtaagt tagtaaaaaa agtaaattta gatactacac acgaagtaaa tactttaaat  2880
gctgcatttt ttatacaatc attaatagaa tataatagtt ctaaagaatc tcttagtaat  2940
ttaagtgtag caatgaaagt ccaagtttac gctcaattat ttagtactgg tttaaatact  3000
attacagatg cagccaaagt tgttgaatta gtatcaactg cattagatga aactatagac  3060
ttacttccta cattatctga aggattacct ataattgcaa ctattataga tggtgtaagt  3120
ttaggtgcag caatcaaaga gctaagtgaa acgagtgacc cattattaag acaagaaata  3180
gaagctaaga taggtataat ggcagtaaat ttaacaacag ctacaactgc aatcattact  3240
tcatctttgg ggatagctag tggatttagt atacttttag ttcctttagc aggaatttca  3300
gcaggtatac caagcttagt aaacaatgaa cttgtacttc gagataaggc aacaaaggtt  3360
gtagattatt ttaaacatgt ttcattagtt gaaactgaag gagtatttac tttattagat  3420
gataaaataa tgatgccaca agatgattta gtgatatcag aaatagattt taataataat  3480
tcaatagttt taggtaaatg tgaaatctgg agaatggaag gtggttcagg tcatactgta  3540
actgatgata tagatcactt cttttcagca ccatcaataa catatagaga gccacactta  3600
tctatatatg acgtattgga agtacaaaaa gaagaacttg atttgtcaaa agatttaatg  3660
gtattaccta atgctccaaa tagagtattt gcttgggaaa caggatggac accaggttta  3720
agaagcttag aaaatgatgg cacaaaactg ttagaccgta taagagataa ctatgaaggt  3780
gagttttatt ggagatattt tgcttttata gctgatgctt taataacaac attaaaacca  3840
agatatgaag atactaatat aagaataaat ttagatagta atactagaag ttttatagtt  3900
ccaataataa ctacagaata tataagagaa aaattatcat attctttcta tggttcagga  3960
ggaacttatg cattgtctct ttctcaatat aatatgggta taaatataga attaagtgaa  4020
agtgatgttt ggattataga tgttgataat gttgtgagag atgtaactat agaatctgat  4080
aaaattaaaa aaggtgattt aatagaaggt attttatcta cactaagtat tgaagagaat  4140
aaaattatct taaatagcca tgagattaat ttttctggtg aggtaaatgg aagtaatgga  4200
tttgtttctt taacattttc aattttagaa ggaataaatg caattataga agttgattta  4260
ttatctaaat catataaatt acttatttct ggcgaattaa aaatattgat gttaaattca  4320
aatcatattc aacagaaaat agattatata ggattcaata gcgaattaca gaaaaatata  4380
ccatatagct ttgtagatag tgaaggaaaa gagaatggtt ttattaatgg ttcaacaaaa  4440
gaaggtttat ttgtatctga attacctgat gtagttctta taagtaaggt ttatatggat  4500
gatagtaagc cttcatttgg atattatagt aataatttga aagatgtcaa agttataact  4560
aaagataatg ttaatatatt aacaggttat tatcttaagg atgatataaa aatctctctt  4620
tctttgactc tacaagatga aaaaactata aagttaaata gtgtgcattt agatgaaagt  4680
ggagtagctg agattttgaa gttcatgaat agaaaaggta atacaaatac ttcagattct  4740
ttaatgagct ttttagaaag tatgaatata aaaagtattt tcgttaattt cttacaatct  4800
aatattaagt ttatattaga tgctaatttt ataataagtg gtactacttc tattggccaa  4860
tttgagttta tttgtgatga aaatgataat atacaaccat atttcattaa gtttaataca  4920
ctagaaacta attatacttt atatgtagga aatagacaaa atatgatagt ggaaccaaat  4980
tatgatttag atgattctgg agatatatct tcaactgtta tcaatttctc tcaaaagtat  5040
ctttatggaa tagacagttg tgttaataaa gttgtaattt caccaaatat ttatacagat  5100
gaaataaata taacgcctgt atatgaaaca aataatactt atccagaagt tattgtatta  5160
gatgcaaatt atataaatga aaaaataaat gttaatatca atgatctatc tatacgatat  5220
gtatggagta atgatggtaa tgattttatt cttatgtcaa ctagtgaaga aaataaggtg  5280
tcacaagtta aaataagatt cgttaatgtt tttaaagata agactttggc aaataagcta  5340
tcttttaact ttagtgataa acaagatgta cctgtaagtg aaataatctt atcatttaca  5400
ccttcatatt atgaggatgg attgattggc tatgatttgg gtctagtttc tttatataat  5460
gagaaatttt atattaataa ctttggaatg atggtatctg gattaatata tattaatgat  5520
tcattatatt attttaaacc accagtaaat aatttgataa ctggatttgt gactgtaggc  5580
gatgataaat actactttaa tccaattaat ggtggagctg cttcaattgg agagacaata  5640
attgatgaca aaaattatta tttcaaccaa agtggagtgt tacaaacagg tgtatttagt  5700
acagaagatg gatttaaata ttttgcccca gctaatacac ttgatgaaaa cctagaagga  5760
gaagcaattg attttactgg aaaattaatt attgacgaaa atatttatta ttttgatgat  5820
aattatagag gagctgtaga atggaaagaa ttagatggtg aaatgcacta ttttagccca  5880
gaaacaggta aagcttttaa aggtctaaat caaataggtg attataaata ctatttcaat  5940
tctgatggag ttatgcaaaa aggatttgtt agtataaatg ataataaaca ctattttgat  6000
gattctggtg ttatgaaagt aggttacact gaaatagatg gcaagcattt ctactttgct  6060
gaaaacggag aaatgcaaat aggagtattt aatacagaag atggatttaa atattttgct  6120
catcataatg aagatttagg aaatgaagaa ggtgaagaaa tctcatattc tggtatatta  6180
aatttcaata ataaaattta ctattttgat gattcattta cagctgtagt tggatggaaa  6240
gatttagagg atggttcaaa gtattatttt gatgaagata cagcagaagc atatataggt  6300
ttgtcattaa taaatgatgg tcaatattat tttaatgatg atggaattat gcaagttgga  6360
tttgtcacta taaatgataa agtcttctac ttctctgact ctggaattat agaatctgga  6420
gtacaaaaca tagatgacaa ttatttctat atagatgata atggtatagt tcaaattggt  6480
gtatttgata cttcagatgg atataaatat tttgcacctg ctaatactgt aaatgataat  6540
atttacggac aagcagttga atatagtggt ttagttagag ttggtgaaga tgtatattat  6600
tttggagaaa catatacaat tgagactgga tggatatatg atatggaaaa tgaaagtgat  6660
aaatattatt tcaatccaga aactaaaaaa gcatgcaaag gtattaattt aattgatgat  6720
ataaaatatt attttgatga gaagggcata atgagaacgg gtcttatatc atttgaaaat  6780
aataattatt actttaatga gaatggtgaa atgcaatttg gttatataaa tatagaagat  6840
aagatgttct attttggtga agatggtgtc atgcagattg gagtatttaa tacaccagat  6900
ggatttaaat actttgcaca tcaaaatact ttggatgaga attttgaggg agaatcaata  6960
aactatactg gttggttaga tttagatgaa aagagatatt attttacaga tgaatatatt  7020
gcagcaactg gttcagttat tattgatggt gaggagtatt attttgatcc tgatacagct  7080
caattagtga ttagtgaata g                                            7101

<210>   32
<211>   2307
<212>   DNA
<213>   Clostridium difficile

<400>   32
atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa  60
aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat  120
aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat  180
aaatataaaa cttcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa  240
gaagtaattc ttattaaaaa ttccaataca agccctgtag aaaaaaattt acattttgta  300
tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt  360
aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt aaatacacta  420
aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt  480
caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat  540
agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca  600
atagatgata ttataaagtc tcatctagta tctgaatata atagagatga aactgtatta  660
gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg  720
gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat  780
cgtggaaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc  840
ggagtatatt tagatgttga tatgcttcca ggtattcact ctgatttatt taaaacaata  900
tctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg  960
aagtataaaa aatatataaa taattataca tcagaaaact ttgataaact tgatcaacaa  1020
ttaaaagata attttaaact cattatagaa agtaaaagtg aaaaatctga gatattttct  1080
aaattagaaa atttaaatgt atctgatctt gaaattaaaa tagctttcgc tttaggcagt  1140
gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa  1200
caagtaaaaa atagatatca atttttaaac caacacctta acccagccat agagtctgat  1260
aataacttca cagatactac taaaattttt catgattcat tatttaattc agctaccgca  1320
gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa  1380
gctcgctcca caataagttt aagtggtcca ggagcttatg cgtcagctta ctatgatttc  1440
ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt  1500
aaattcccag aaaataatct atctcaattg acagaacaag aaataaatag tctatggagc  1560
tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga  1620
tctctttctg aagacaatgg ggtagacttt aataaaaata ctgccctcga caaaaactat  1680
ttattaaata ataaaattcc atcaaacaat gtagaagaag ctggaagtaa aaattatgtt  1740
cattatatca tacagttaca aggagatgat ataagttatg aagcaacatg caatttattt  1800
tctaaaaatc ctaaaaatag tattattata caacgaaata tgaatgaaag tgcaaaaagc  1860
tactttttaa gtgatgatgg agaatctatt ttagaattaa ataaatatag gatacctgaa  1920
agattaaaaa ataaggaaaa agtaaaagta acctttattg gacatggtaa agatgaattc  1980
aacacaagcg aatttgctag attaagtgta gattcacttt ccaatgagat aagttcattt  2040
ttagatacca taaaattaga tatatcacct aaaaatgtag aagtaaactt acttggatgt  2100
aatatgttta gttatgattt taatgttgaa gaaacttatc ctgggaagtt gctattaagt  2160
attatggaca aaattacttc cactttacct gatgtaaata aaaattctat tactatagga  2220
gcaaatcaat atgaagtaag aattaatagt gagggaagaa aagaacttct ggctcactca  2280
ggtaaatgga taaataaaga agaagct                                      2307

<210>   33
<211>   1623
<212>   DNA
<213>   Clostridium difficile

<400>   33
atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa  60
aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat  120
aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat  180
aaatataaaa cttcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa  240
gaagtaattc ttattaaaaa ttccaataca agccctgtag aaaaaaattt acattttgta  300
tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt  360
aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt aaatacacta  420
aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt  480
caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat  540
agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca  600
atagatgata ttataaagtc tcatctagta tctgaatata atagagatga aactgtatta  660
gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg  720
gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat  780
cgtggaaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc  840
ggagtatatt tagatgttga tatgcttcca ggtattcact ctgatttatt taaaacaata  900
tctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg  960
aagtataaaa aatatataaa taattataca tcagaaaact ttgataaact tgatcaacaa  1020
ttaaaagata attttaaact cattatagaa agtaaaagtg aaaaatctga gatattttct  1080
aaattagaaa atttaaatgt atctgatctt gaaattaaaa tagctttcgc tttaggcagt  1140
gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa  1200
caagtaaaaa atagatatca atttttaaac caacacctta acccagccat agagtctgat  1260
aataacttca cagatactac taaaattttt catgattcat tatttaattc agctaccgca  1320
gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa  1380
gctcgctcca caataagttt aagtggtcca ggagcttatg cgtcagctta ctatgatttc  1440
ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt  1500
aaattcccag aaaataatct atctcaattg acagaacaag aaataaatag tctatggagc  1560
tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga  1620
tct                                                                1623

<210>   34
<211>   684
<212>   DNA
<213>   Clostridium difficile

<400>   34
tctgaagaca atggggtaga ctttaataaa aatactgccc tcgacaaaaa ctatttatta  60
aataataaaa ttccatcaaa caatgtagaa gaagctggaa gtaaaaatta tgttcattat  120
atcatacagt tacaaggaga tgatataagt tatgaagcaa catgcaattt attttctaaa  180
aatcctaaaa atagtattat tatacaacga aatatgaatg aaagtgcaaa aagctacttt  240
ttaagtgatg atggagaatc tattttagaa ttaaataaat ataggatacc tgaaagatta  300
aaaaataagg aaaaagtaaa agtaaccttt attggacatg gtaaagatga attcaacaca  360
agcgaatttg ctagattaag tgtagattca ctttccaatg agataagttc atttttagat  420
accataaaat tagatatatc acctaaaaat gtagaagtaa acttacttgg atgtaatatg  480
tttagttatg attttaatgt tgaagaaact tatcctggga agttgctatt aagtattatg  540
gacaaaatta cttccacttt acctgatgta aataaaaatt ctattactat aggagcaaat  600
caatatgaag taagaattaa tagtgaggga agaaaagaac ttctggctca ctcaggtaaa  660
tggataaata aagaagaagc tctt                                         684

<210>   35
<211>   3114
<212>   DNA
<213>   Clostridium difficile

<400>   35
atgagcgatt tatctagtaa agaatacatt ttttttgatt ctatagataa taagctaaaa  60
gcaaagtcca agaatattcc aggattagca tcaatatcag aagatataaa aacattatta  120
cttgatgcaa gtgttagtcc tgatacaaaa tttattttaa ataatcttaa gcttaatatt  180
gaatcttcta ttggtgatta catttattat gaaaaattag agcctgttaa aaatataatt  240
cacaattcta tagatgattt aatagatgag ttcaatctac ttgaaaatgt atctgatgaa  300
ttatatgaat taaaaaaatt aaataatcta gatgagaagt atttaatatc ttttgaagat  360
atctcaaaaa ataattcaac ttactctgta agatttatta acaaaagtaa tggtgagtca  420
gtttatgtag aaacagaaaa agaaattttt tcaaaatata gcgaacatat tacaaaagaa  480
ataagtacta taaagaatag tataattaca gatgttaatg gtaatttatt ggataatata  540
cagttagatc atacttctca agttaataca ttaaacgcag cattctttat tcaatcatta  600
atagattata gtagcaataa agatgtactg aatgatttaa gtacctcagt taaggttcaa  660
ctttatgctc aactatttag tacaggttta aatactatat atgactctat ccaattagta  720
aatttaatat caaatgcagt aaatgatact ataaatgtac tacctacaat aacagagggg  780
atacctattg tatctactat attagacgga ataaacttag gtgcagcaat taaggaatta  840
ctagacgaac atgacccatt actaaaaaaa gaattagaag ctaaggtggg tgttttagca  900
ataaatatgt cattatctat agctgcaact gtagcttcaa ttgttggaat aggtgctgaa  960
gttactattt tcttattacc tatagctggt atatctgcag gaataccttc attagttaat  1020
aatgaattaa tattgcatga taaggcaact tcagtggtaa actattttaa tcatttgtct  1080
gaatctaaaa aatatggccc tcttaaaaca gaagatgata aaattttagt tcctattgat  1140
gatttagtaa tatcagaaat agattttaat aataattcga taaaactagg aacatgtaat  1200
atattagcaa tggagggggg atcaggacac acagtgactg gtaatataga tcactttttc  1260
tcatctccat ctataagttc tcatattcct tcattatcaa tttattctgc aataggtata  1320
gaaacagaaa atctagattt ttcaaaaaaa ataatgatgt tacctaatgc tccttcaaga  1380
gtgttttggt gggaaactgg agcagttcca ggtttaagat cattggaaaa tgacggaact  1440
agattacttg attcaataag agatttatac ccaggtaaat tttactggag attctatgct  1500
tttttcgatt atgcaataac tacattaaaa ccagtttatg aagacactaa tattaaaatt  1560
aaactagata aagatactag aaacttcata atgccaacta taactactaa cgaaattaga  1620
aacaaattat cttattcatt tgatggagca ggaggaactt actctttatt attatcttca  1680
tatccaatat caacgaatat aaatttatct aaagatgatt tatggatatt taatattgat  1740
aatgaagtaa gagaaatatc tatagaaaat ggtactatta aaaaaggaaa gttaataaaa  1800
gatgttttaa gtaaaattga tataaataaa aataaactta ttataggcaa tcaaacaata  1860
gatttttcag gcgatataga taataaagat agatatatat tcttgacttg tgagttagat  1920
gataaaatta gtttaataat agaaataaat cttgttgcaa aatcttatag tttgttattg  1980
tctggggata aaaattattt gatatccaat ttatctaata ttattgagaa aatcaatact  2040
ttaggcctag atagtaaaaa tatagcgtac aattacactg atgaatctaa taataaatat  2100
tttggagcta tatctaaaac aagtcaaaaa agcataatac attataaaaa agacagtaaa  2160
aatatattag aattttataa tgacagtaca ttagaattta acagtaaaga ttttattgct  2220
gaagatataa atgtatttat gaaagatgat attaatacta taacaggaaa atactatgtt  2280
gataataata ctgataaaag tatagatttc tctatttctt tagttagtaa aaatcaagta  2340
aaagtaaatg gattatattt aaatgaatcc gtatactcat cttaccttga ttttgtgaaa  2400
aattcagatg gacaccataa tacttctaat tttatgaatt tatttttgga caatataagt  2460
ttctggaaat tgtttgggtt tgaaaatata aattttgtaa tcgataaata ctttaccctt  2520
gttggtaaaa ctaatcttgg atatgtagaa tttatttgtg acaataataa aaatatagat  2580
atatattttg gtgaatggaa aacatcgtca tctaaaagca ctatatttag cggaaatggt  2640
agaaatgttg tagtagagcc tatatataat cctgatacgg gtgaagatat atctacttca  2700
ctagattttt cctatgaacc tctctatgga atagatagat atatcaataa agtattgata  2760
gcacctgatt tatatacaag tttaataaat attaatacca attattattc aaatgagtac  2820
taccctgaga ttatagttct taacccaaat acattccaca aaaaagtaaa tataaattta  2880
gatagttctt cttttgagta taaatggtct acagaaggaa gtgactttat tttagttaga  2940
tacttagaag aaagtaataa aaaaatatta caaaaaataa gaatcaaagg tatcttatct  3000
aatactcaat catttaataa aatgagtata gattttaaag atattaaaaa actatcatta  3060
ggatatataa tgagtaattt taaatcattt aattctgaaa atgaattaga taga        3114

<210>   36
<211>   798
<212>   DNA
<213>   Clostridium difficile

<400>   36
gaagatataa atgtatttat gaaagatgat attaatacta taacaggaaa atactatgtt  60
gataataata ctgataaaag tatagatttc tctatttctt tagttagtaa aaatcaagta  120
aaagtaaatg gattatattt aaatgaatcc gtatactcat cttaccttga ttttgtgaaa  180
aattcagatg gacaccataa tacttctaat tttatgaatt tatttttgga caatataagt  240
ttctggaaat tgtttgggtt tgaaaatata aattttgtaa tcgataaata ctttaccctt  300
gttggtaaaa ctaatcttgg atatgtagaa tttatttgtg acaataataa aaatatagat  360
atatattttg gtgaatggaa aacatcgtca tctaaaagca ctatatttag cggaaatggt  420
agaaatgttg tagtagagcc tatatataat cctgatacgg gtgaagatat atctacttca  480
ctagattttt cctatgaacc tctctatgga atagatagat atatcaataa agtattgata  540
gcacctgatt tatatacaag tttaataaat attaatacca attattattc aaatgagtac  600
taccctgaga ttatagttct taacccaaat acattccaca aaaaagtaaa tataaattta  660
gatagttctt cttttgagta taaatggtct acagaaggaa gtgactttat tttagttaga  720
tacttagaag aaagtaataa aaaaatatta caaaaaataa gaatcaaagg tatcttatct  780
aatactcaat catttaat                                                798

<210>   37
<211>   2649
<212>   DNA
<213>   Clostridium difficile

<400>   37
gatcatttag gatttaaaat aatagataat aaaacttatt actatgatga agatagtaaa  60
ttagttaaag gattaatcaa tataaataat tcattattct attttgatcc tatagaattt  120
aacttagtaa ctggatggca aactatcaat ggtaaaaaat attattttga tataaatact  180
ggagcagctt taattagtta taaaattatt aatggtaaac acttttattt taataatgat  240
ggtgtgatgc agttgggagt atttaaagga cctgatggat ttgaatattt tgcacctgcc  300
aatactcaaa ataataacat agaaggtcag gctatagttt atcaaagtaa attcttaact  360
ttgaatggca aaaaatatta ttttgataat gactcaaaag cagtcactgg atggagaatt  420
attaacaatg agaaatatta ctttaatcct aataatgcta ttgctgcagt cggattgcaa  480
gtaattgaca ataataagta ttatttcaat cctgacactg ctatcatctc aaaaggttgg  540
cagactgtta atggtagtag atactacttt gatactgata ccgctattgc ctttaatggt  600
tataaaacta ttgatggtaa acacttttat tttgatagtg attgtgtagt gaaaataggt  660
gtgtttagta cctctaatgg atttgaatat tttgcacctg ctaatactta taataataac  720
atagaaggtc aggctatagt ttatcaaagt aaattcttaa ctttgaatgg taaaaaatat  780
tactttgata ataactcaaa agcagttacc ggatggcaaa ctattgatag taaaaaatat  840
tactttaata ctaacactgc tgaagcagct actggatggc aaactattga tggtaaaaaa  900
tattacttta atactaacac tgctgaagca gctactggat ggcaaactat tgatggtaaa  960
aaatattact ttaatactaa cactgctata gcttcaactg gttatacaat tattaatggt  1020
aaacattttt attttaatac tgatggtatt atgcagatag gagtgtttaa aggacctaat  1080
ggatttgaat attttgcacc tgctaatacg gatgctaaca acatagaagg tcaagctata  1140
ctttaccaaa atgaattctt aactttgaat ggtaaaaaat attactttgg tagtgactca  1200
aaagcagtta ctggatggag aattattaac aataagaaat attactttaa tcctaataat  1260
gctattgctg caattcatct atgcactata aataatgaca agtattactt tagttatgat  1320
ggaattcttc aaaatggata tattactatt gaaagaaata atttctattt tgatgctaat  1380
aatgaatcta aaatggtaac aggagtattt aaaggaccta atggatttga gtattttgca  1440
cctgctaata ctcacaataa taacatagaa ggtcaggcta tagtttacca gaacaaattc  1500
ttaactttga atggcaaaaa atattatttt gataatgact caaaagcagt tactggatgg  1560
caaaccattg atggtaaaaa atattacttt aatcttaaca ctgctgaagc agctactgga  1620
tggcaaacta ttgatggtaa aaaatattac tttaatctta acactgctga agcagctact  1680
ggatggcaaa ctattgatgg taaaaaatat tactttaata ctaacacttt catagcctca  1740
actggttata caagtattaa tggtaaacat ttttatttta atactgatgg tattatgcag  1800
ataggagtgt ttaaaggacc taatggattt gaatactttg cacctgctaa tactcataat  1860
aataacatag aaggtcaagc tatactttac caaaataaat tcttaacttt gaatggtaaa  1920
aaatattact ttggtagtga ctcaaaagca gttaccggat tgcgaactat tgatggtaaa  1980
aaatattact ttaatactaa cactgctgtt gcagttactg gatggcaaac tattaatggt  2040
aaaaaatact actttaatac taacacttct atagcttcaa ctggttatac aattattagt  2100
ggtaaacatt tttattttaa tactgatggt attatgcaga taggagtgtt taaaggacct  2160
gatggatttg aatactttgc acctgctaat acagatgcta acaatataga aggtcaagct  2220
atacgttatc aaaatagatt cctatattta catgacaata tatattattt tggtaataat  2280
tcaaaagcag ctactggttg ggtaactatt gatggtaata gatattactt cgagcctaat  2340
acagctatgg gtgcgaatgg ttataaaact attgataata aaaattttta ctttagaaat  2400
ggtttacctc agataggagt gtttaaaggg tctaatcgtt atcaaaatag attcctacat  2460
ttacttggaa aaatatatta ctttggtaat aattcaaaag cagttactgg atggcaaact  2520
attaatggta aagtatatta ctttatgcct gatactgcta tggctgcagc tggtggactt  2580
ttcgagattg atggtgttat atatttcttt ggtgttgatg gagtaaaagc ccctgggata  2640
tatggctaa                                                          2649

<210>   38
<211>   612
<212>   DNA
<213>   Clostridium difficile

<400>   38
agatactact ttgatactga taccgctatt gcctttaatg gttataaaac tattgatggt  60
aaacactttt attttgatag tgattgtgta gtgaaaatag gtgtgtttag tacctctaat  120
ggatttgaat attttgcacc tgctaatact tataataata acatagaagg tcaggctata  180
gtttatcaaa gtaaattctt aactttgaat ggtaaaaaat attactttga taataactca  240
aaagcagtta ccggatggca aactattgat agtaaaaaat attactttaa tactaacact  300
gctgaagcag ctactggatg gcaaactatt gatggtaaaa aatattactt taatactaac  360
actgctgaag cagctactgg atggcaaact attgatggta aaaaatatta ctttaatact  420
aacactgcta tagcttcaac tggttataca attattaatg gtaaacattt ttattttaat  480
actgatggta ttatgcagat aggagtgttt aaaggaccta atggatttga atattttgca  540
cctgctaata cggatgctaa caacatagaa ggtcaagcta tactttacca aaatgaattc  600
ttaactttga at                                                      612

<210>   39
<211>   1371
<212>   DNA
<213>   Clostridium difficile

<400>   39
atcctgcaga acggctatat caccatcgaa cgtaataact tctacttcga tgccaataac  60
gaatccaaaa tggtgacggg cgtgtttaaa ggcccaaatg gttttgagta tttcgcgccg  120
gcaaacaccc acaataacaa cattgaaggt caagccattg tttaccaaaa caaattcctg  180
accctaaatg gaaaaaaata ttactttgat aacgacagca aagcggtcac cggctggcag  240
acaatcgacg gtaaaaaata ttactttaat cttaacaccg cagaagcggc caccggctgg  300
caaaccatcg atggtaaaaa atattacttc aacttgaaca ccgcagaagc ggccaccggc  360
tggcagacca tcgatggtaa aaaatactac tttaatacca acaccttcat tgctagcacc  420
ggttatactt cgatcaacgg taaacatttt tactttaata ccgacggtat catgcaaatt  480
ggcgtattca aaggtcctaa cggctttgaa tactttgcgc cagcaaatac ccacaacaat  540
aacattgaag gtcaggccat tctgtaccaa aacaaattcc tgaccctaaa tggtaaaaaa  600
tattacttcg gtagtgacag caaagcggtt acaggcctaa ggaccatcga tggtaaaaaa  660
tattacttta acaccaacac cgcagtcgcg gttaccggct ggcagaccat caatggtaaa  720
aaatactact ttaacaccaa cacctctatt gccagcaccg gttacacgat catctcgggt  780
aaacatttct attttaatac cgatggtatc atgcaaattg gcgtatttaa aggtccggac  840
ggcttcgaat actttgcgcc tgcaaacacg gatgccaaca atattgaggg tcaggcaatt  900
agatatcaaa accgcttcct ctacctgcat gacaatattt attactttgg taacaatagc  960
aaagcggcca ccggttgggt gaccatcgat ggtaaccgtt attacttcga gccaaatacg  1020
gcaatgggtg ctaacggtta taaaaccatc gacaataaaa acttctactt tcgcaatggt  1080
ctgccgcaaa ttggcgtatt taaaggatct aacggcttcg aatactttgc gcctgccaat  1140
acagatgcaa acaacattga aggtcaggcc attagatacc aaaatcgttt cctccattta  1200
cttggcaaaa tttattactt tggtaacaat agcaaagcgg tcaccggttg gcaaaccatc  1260
aacggtaaag tgtattactt tatgccagat accgcaatgg ccgcggcagg tggcttgttc  1320
gagatcgacg gtgttattta cttcttcggt gtcgatggcg tgaaagctcc g           1371

<210>   40
<211>   955
<212>   DNA
<213>   Clostridium difficile

<400>   40
gcctcaactg gttatacaag tattaatggt aaacattttt attttaatac tgatggtatt  60
atgcagatag gagtgtttaa aggacctaat ggatttgaat actttgcacc tgctaatact  120
cataataata acatagaagg tcaagctata ctttaccaaa ataaattctt aactttgaat  180
ggtaaaaaat attactttgg tagtgactca aaagcagtta ccggattgcg aactattgat  240
ggtaaaaaat attactttaa tactaacact gctgttgcag ttactggatg gcaaactatt  300
aatggtaaaa aatactactt taatactaac acttctatag cttcaactgg ttatacaatt  360
attagtggta aacattttta ttttaatact gatggtatta tgcagatagg agtgtttaaa  420
ggacctgatg gatttgaata ctttgcacct gctaatacag atgctaacaa tatagaaggt  480
caagctatac gttatcaaaa tagattccta tatttacatg acaatatata ttattttggt  540
aataattcaa aagcagctac tggttgggta actattgatg gtaatagata ttacttcgag  600
cctaatacag ctatgggtgc gaatggttat aaaactattg ataataaaaa tttttacttt  660
agaaatggtt tacctcagat aggagtgttt aaagggtcta atggatttga atactttgca  720
cctgctaata cggatgctaa caatatagaa ggtcaagcta tacgttatca aaatagattc  780
ctacatttac ttggaaaaat atattacttt ggtaataatt caaaagcagt tactggatgg  840
caaactatta atggtaaagt atattacttt atgcctgata ctgctatggc tgcagctggt  900
ggacttttcg agattgatgg tgttatatat ttctttggtg ttgatggagt aaaag       955

<210>   41
<211>   2592
<212>   DNA
<213>   Clostridium difficile

<400>   41
tttgatccta tagaatttaa cttagtaact ggatggcaaa ctatcaatgg taaaaaatat  60
tattttgata taaatactgg agcagcttta attagttata aaattattaa tggtaaacac  120
ttttatttta ataatgatgg tgtgatgcag ttgggagtat ttaaaggacc tgatggattt  180
gaatattttg cacctgccaa tactcaaaat aataacatag aaggtcaggc tatagtttat  240
caaagtaaat tcttaacttt gaatggcaaa aaatattatt ttgataatga ctcaaaagca  300
gtcactggat ggagaattat taacaatgag aaatattact ttaatcctaa taatgctatt  360
gctgcagtcg gattgcaagt aattgacaat aataagtatt atttcaatcc tgacactgct  420
atcatctcaa aaggttggca gactgttaat ggtagtagat actactttga tactgatacc  480
gctattgcct ttaatggtta taaaactatt gatggtaaac acttttattt tgatagtgat  540
tgtgtagtga aaataggtgt gtttagtacc tctaatggat ttgaatattt tgcacctgct  600
aatacttata ataataacat agaaggtcag gctatagttt atcaaagtaa attcttaact  660
ttgaatggta aaaaatatta ctttgataat aactcaaaag cagttaccgg atggcaaact  720
attgatagta aaaaatatta ctttaatact aacactgctg aagcagctac tggatggcaa  780
actattgatg gtaaaaaata ttactttaat actaacactg ctgaagcagc tactggatgg  840
caaactattg atggtaaaaa atattacttt aatactaaca ctgctatagc ttcaactggt  900
tatacaatta ttaatggtaa acatttttat tttaatactg atggtattat gcagatagga  960
gtgtttaaag gacctaatgg atttgaatat tttgcacctg ctaatacgga tgctaacaac  1020
atagaaggtc aagctatact ttaccaaaat gaattcttaa ctttgaatgg taaaaaatat  1080
tactttggta gtgactcaaa agcagttact ggatggagaa ttattaacaa taagaaatat  1140
tactttaatc ctaataatgc tattgctgca attcatctat gcactataaa taatgacaag  1200
tattacttta gttatgatgg aattcttcaa aatggatata ttactattga aagaaataat  1260
ttctattttg atgctaataa tgaatctaaa atggtaacag gagtatttaa aggacctaat  1320
ggatttgagt attttgcacc tgctaatact cacaataata acatagaagg tcaggctata  1380
gtttaccaga acaaattctt aactttgaat ggcaaaaaat attattttga taatgactca  1440
aaagcagtta ctggatggca aaccattgat ggtaaaaaat attactttaa tcttaacact  1500
gctgaagcag ctactggatg gcaaactatt gatggtaaaa aatattactt taatcttaac  1560
actgctgaag cagctactgg atggcaaact attgatggta aaaaatatta ctttaatact  1620
aacactttca tagcctcaac tggttataca agtattaatg gtaaacattt ttattttaat  1680
actgatggta ttatgcagat aggagtgttt aaaggaccta atggatttga atactttgca  1740
cctgctaata ctcataataa taacatagaa ggtcaagcta tactttacca aaataaattc  1800
ttaactttga atggtaaaaa atattacttt ggtagtgact caaaagcagt taccggattg  1860
cgaactattg atggtaaaaa atattacttt aatactaaca ctgctgttgc agttactgga  1920
tggcaaacta ttaatggtaa aaaatactac tttaatacta acacttctat agcttcaact  1980
ggttatacaa ttattagtgg taaacatttt tattttaata ctgatggtat tatgcagata  2040
ggagtgttta aaggacctga tggatttgaa tactttgcac ctgctaatac agatgctaac  2100
aatatagaag gtcaagctat acgttatcaa aatagattcc tatatttaca tgacaatata  2160
tattattttg gtaataattc aaaagcagct actggttggg taactattga tggtaataga  2220
tattacttcg agcctaatac agctatgggt gcgaatggtt ataaaactat tgataataaa  2280
aatttttact ttagaaatgg tttacctcag ataggagtgt ttaaagggtc taatggattt  2340
gaatactttg cacctgctaa tacggatgct aacaatatag aaggtcaagc tatacgttat  2400
caaaatagat tcctacattt acttggaaaa atatattact ttggtaataa ttcaaaagca  2460
gttactggat ggcaaactat taatggtaaa gtatattact ttatgcctga tactgctatg  2520
gctgcagctg gtggactttt cgagattgat ggtgttatat atttctttgg tgttgatgga  2580
gtaaaagccc ct                                                      2592

<210>   42
<211>   807
<212>   DNA
<213>   Clostridium difficile

<400>   42
taccaaaata aattcttaac tttgaatggt aaaaaatatt actttggtag tgactcaaaa  60
gcagttaccg gattgcgaac tattgatggt aaaaaatatt actttaatac taacactgct  120
gttgcagtta ctggatggca aactattaat ggtaaaaaat actactttaa tactaacact  180
tctatagctt caactggtta tacaattatt agtggtaaac atttttattt taatactgat  240
ggtattatgc agataggagt gtttaaagga cctgatggat ttgaatactt tgcacctgct  300
aatacagatg ctaacaatat agaaggtcaa gctatacgtt atcaaaatag attcctatat  360
ttacatgaca atatatatta ttttggtaat aattcaaaag cagctactgg ttgggtaact  420
attgatggta atagatatta cttcgagcct aatacagcta tgggtgcgaa tggttataaa  480
actattgata ataaaaattt ttactttaga aatggtttac ctcagatagg agtgtttaaa  540
gggtctaatg gatttgaata ctttgcacct gctaatacgg atgctaacaa tatagaaggt  600
caagctatac gttatcaaaa tagattccta catttacttg gaaaaatata ttactttggt  660
aataattcaa aagcagttac tggatggcaa actattaatg gtaaagtata ttactttatg  720
cctgatactg ctatggctgc agctggtgga cttttcgaga ttgatggtgt tatatatttc  780
tttggtgttg atggagtaaa agcccct                                      807

<210>   43
<211>   2616
<212>   DNA
<213>   Clostridium difficile

<400>   43
tcattattct attttgatcc tatagaattt aacttagtaa ctggatggca aactatcaat  60
ggtaaaaaat attattttga tataaatact ggagcagctt taattagtta taaaattatt  120
aatggtaaac acttttattt taataatgat ggtgtgatgc agttgggagt atttaaagga  180
cctgatggat ttgaatattt tgcacctgcc aatactcaaa ataataacat agaaggtcag  240
gctatagttt atcaaagtaa attcttaact ttgaatggca aaaaatatta ttttgataat  300
gactcaaaag cagtcactgg atggagaatt attaacaatg agaaatatta ctttaatcct  360
aataatgcta ttgctgcagt cggattgcaa gtaattgaca ataataagta ttatttcaat  420
cctgacactg ctatcatctc aaaaggttgg cagactgtta atggtagtag atactacttt  480
gatactgata ccgctattgc ctttaatggt tataaaacta ttgatggtaa acacttttat  540
tttgatagtg attgtgtagt gaaaataggt gtgtttagta cctctaatgg atttgaatat  600
tttgcacctg ctaatactta taataataac atagaaggtc aggctatagt ttatcaaagt  660
aaattcttaa ctttgaatgg taaaaaatat tactttgata ataactcaaa agcagttacc  720
ggatggcaaa ctattgatag taaaaaatat tactttaata ctaacactgc tgaagcagct  780
actggatggc aaactattga tggtaaaaaa tattacttta atactaacac tgctgaagca  840
gctactggat ggcaaactat tgatggtaaa aaatattact ttaatactaa cactgctata  900
gcttcaactg gttatacaat tattaatggt aaacattttt attttaatac tgatggtatt  960
atgcagatag gagtgtttaa aggacctaat ggatttgaat attttgcacc tgctaatacg  1020
gatgctaaca acatagaagg tcaagctata ctttaccaaa atgaattctt aactttgaat  1080
ggtaaaaaat attactttgg tagtgactca aaagcagtta ctggatggag aattattaac  1140
aataagaaat attactttaa tcctaataat gctattgctg caattcatct atgcactata  1200
aataatgaca agtattactt tagttatgat ggaattcttc aaaatggata tattactatt  1260
gaaagaaata atttctattt tgatgctaat aatgaatcta aaatggtaac aggagtattt  1320
aaaggaccta atggatttga gtattttgca cctgctaata ctcacaataa taacatagaa  1380
ggtcaggcta tagtttacca gaacaaattc ttaactttga atggcaaaaa atattatttt  1440
gataatgact caaaagcagt tactggatgg caaaccattg atggtaaaaa atattacttt  1500
aatcttaaca ctgctgaagc agctactgga tggcaaacta ttgatggtaa aaaatattac  1560
tttaatctta acactgctga agcagctact ggatggcaaa ctattgatgg taaaaaatat  1620
tactttaata ctaacacttt catagcctca actggttata caagtattaa tggtaaacat  1680
ttttatttta atactgatgg tattatgcag ataggagtgt ttaaaggacc taatggattt  1740
gaatactttg cacctgctaa tactcataat aataacatag aaggtcaagc tatactttac  1800
caaaataaat tcttaacttt gaatggtaaa aaatattact ttggtagtga ctcaaaagca  1860
gttaccggat tgcgaactat tgatggtaaa aaatattact ttaatactaa cactgctgtt  1920
gcagttactg gatggcaaac tattaatggt aaaaaatact actttaatac taacacttct  1980
atagcttcaa ctggttatac aattattagt ggtaaacatt tttattttaa tactgatggt  2040
attatgcaga taggagtgtt taaaggacct gatggatttg aatactttgc acctgctaat  2100
acagatgcta acaatataga aggtcaagct atacgttatc aaaatagatt cctatattta  2160
catgacaata tatattattt tggtaataat tcaaaagcag ctactggttg ggtaactatt  2220
gatggtaata gatattactt cgagcctaat acagctatgg gtgcgaatgg ttataaaact  2280
attgataata aaaattttta ctttagaaat ggtttacctc agataggagt gtttaaaggg  2340
tctaatggat ttgaatactt tgcacctgct aatacggatg ctaacaatat agaaggtcaa  2400
gctatacgtt atcaaaatag attcctacat ttacttggaa aaatatatta ctttggtaat  2460
aattcaaaag cagttactgg atggcaaact attaatggta aagtatatta ctttatgcct  2520
gatactgcta tggctgcagc tggtggactt ttcgagattg atggtgttat atatttcttt  2580
ggtgttgatg gagtaaaagc ccctgggata tatggc                            2616

<210>   44
<211>   2229
<212>   DNA
<213>   Clostridium difficile

<400>   44
gcagtcggat tgcaagtaat tgacaataat aagtattatt tcaatcctga cactgctatc  60
atctcaaaag gttggcagac tgttaatggt agtagatact actttgatac tgataccgct  120
attgccttta atggttataa aactattgat ggtaaacact tttattttga tagtgattgt  180
gtagtgaaaa taggtgtgtt tagtacctct aatggatttg aatattttgc acctgctaat  240
acttataata ataacataga aggtcaggct atagtttatc aaagtaaatt cttaactttg  300
aatggtaaaa aatattactt tgataataac tcaaaagcag ttaccggatg gcaaactatt  360
gatagtaaaa aatattactt taatactaac actgctgaag cagctactgg atggcaaact  420
attgatggta aaaaatatta ctttaatact aacactgctg aagcagctac tggatggcaa  480
actattgatg gtaaaaaata ttactttaat actaacactg ctatagcttc aactggttat  540
acaattatta atggtaaaca tttttatttt aatactgatg gtattatgca gataggagtg  600
tttaaaggac ctaatggatt tgaatatttt gcacctgcta atacggatgc taacaacata  660
gaaggtcaag ctatacttta ccaaaatgaa ttcttaactt tgaatggtaa aaaatattac  720
tttggtagtg actcaaaagc agttactgga tggagaatta ttaacaataa gaaatattac  780
tttaatccta ataatgctat tgctgcaatt catctatgca ctataaataa tgacaagtat  840
tactttagtt atgatggaat tcttcaaaat ggatatatta ctattgaaag aaataatttc  900
tattttgatg ctaataatga atctaaaatg gtaacaggag tatttaaagg acctaatgga  960
tttgagtatt ttgcacctgc taatactcac aataataaca tagaaggtca ggctatagtt  1020
taccagaaca aattcttaac tttgaatggc aaaaaatatt attttgataa tgactcaaaa  1080
gcagttactg gatggcaaac cattgatggt aaaaaatatt actttaatct taacactgct  1140
gaagcagcta ctggatggca aactattgat ggtaaaaaat attactttaa tcttaacact  1200
gctgaagcag ctactggatg gcaaactatt gatggtaaaa aatattactt taatactaac  1260
actttcatag cctcaactgg ttatacaagt attaatggta aacattttta ttttaatact  1320
gatggtatta tgcagatagg agtgtttaaa ggacctaatg gatttgaata ctttgcacct  1380
gctaatactc ataataataa catagaaggt caagctatac tttaccaaaa taaattctta  1440
actttgaatg gtaaaaaata ttactttggt agtgactcaa aagcagttac cggattgcga  1500
actattgatg gtaaaaaata ttactttaat actaacactg ctgttgcagt tactggatgg  1560
caaactatta atggtaaaaa atactacttt aatactaaca cttctatagc ttcaactggt  1620
tatacaatta ttagtggtaa acatttttat tttaatactg atggtattat gcagatagga  1680
gtgtttaaag gacctgatgg atttgaatac tttgcacctg ctaatacaga tgctaacaat  1740
atagaaggtc aagctatacg ttatcaaaat agattcctat atttacatga caatatatat  1800
tattttggta ataattcaaa agcagctact ggttgggtaa ctattgatgg taatagatat  1860
tacttcgagc ctaatacagc tatgggtgcg aatggttata aaactattga taataaaaat  1920
ttttacttta gaaatggttt acctcagata ggagtgttta aagggtctaa tggatttgaa  1980
tactttgcac ctgctaatac ggatgctaac aatatagaag gtcaagctat acgttatcaa  2040
aatagattcc tacatttact tggaaaaata tattactttg gtaataattc aaaagcagtt  2100
actggatggc aaactattaa tggtaaagta tattacttta tgcctgatac tgctatggct  2160
gcagctggtg gacttttcga gattgatggt gttatatatt tctttggtgt tgatggagta  2220
aaagcccct                                                          2229

<210>   45
<211>   2448
<212>   DNA
<213>   Clostridium difficile

<400>   45
atgcagttgg gagtatttaa aggacctgat ggatttgaat attttgcacc tgccaatact  60
caaaataata acatagaagg tcaggctata gtttatcaaa gtaaattctt aactttgaat  120
ggcaaaaaat attattttga taatgactca aaagcagtca ctggatggag aattattaac  180
aatgagaaat attactttaa tcctaataat gctattgctg cagtcggatt gcaagtaatt  240
gacaataata agtattattt caatcctgac actgctatca tctcaaaagg ttggcagact  300
gttaatggta gtagatacta ctttgatact gataccgcta ttgcctttaa tggttataaa  360
actattgatg gtaaacactt ttattttgat agtgattgtg tagtgaaaat aggtgtgttt  420
agtacctcta atggatttga atattttgca cctgctaata cttataataa taacatagaa  480
ggtcaggcta tagtttatca aagtaaattc ttaactttga atggtaaaaa atattacttt  540
gataataact caaaagcagt taccggatgg caaactattg atagtaaaaa atattacttt  600
aatactaaca ctgctgaagc agctactgga tggcaaacta ttgatggtaa aaaatattac  660
tttaatacta acactgctga agcagctact ggatggcaaa ctattgatgg taaaaaatat  720
tactttaata ctaacactgc tatagcttca actggttata caattattaa tggtaaacat  780
ttttatttta atactgatgg tattatgcag ataggagtgt ttaaaggacc taatggattt  840
gaatattttg cacctgctaa tacggatgct aacaacatag aaggtcaagc tatactttac  900
caaaatgaat tcttaacttt gaatggtaaa aaatattact ttggtagtga ctcaaaagca  960
gttactggat ggagaattat taacaataag aaatattact ttaatcctaa taatgctatt  1020
gctgcaattc atctatgcac tataaataat gacaagtatt actttagtta tgatggaatt  1080
cttcaaaatg gatatattac tattgaaaga aataatttct attttgatgc taataatgaa  1140
tctaaaatgg taacaggagt atttaaagga cctaatggat ttgagtattt tgcacctgct  1200
aatactcaca ataataacat agaaggtcag gctatagttt accagaacaa attcttaact  1260
ttgaatggca aaaaatatta ttttgataat gactcaaaag cagttactgg atggcaaacc  1320
attgatggta aaaaatatta ctttaatctt aacactgctg aagcagctac tggatggcaa  1380
actattgatg gtaaaaaata ttactttaat cttaacactg ctgaagcagc tactggatgg  1440
caaactattg atggtaaaaa atattacttt aatactaaca ctttcatagc ctcaactggt  1500
tatacaagta ttaatggtaa acatttttat tttaatactg atggtattat gcagatagga  1560
gtgtttaaag gacctaatgg atttgaatac tttgcacctg ctaatactca taataataac  1620
atagaaggtc aagctatact ttaccaaaat aaattcttaa ctttgaatgg taaaaaatat  1680
tactttggta gtgactcaaa agcagttacc ggattgcgaa ctattgatgg taaaaaatat  1740
tactttaata ctaacactgc tgttgcagtt actggatggc aaactattaa tggtaaaaaa  1800
tactacttta atactaacac ttctatagct tcaactggtt atacaattat tagtggtaaa  1860
catttttatt ttaatactga tggtattatg cagataggag tgtttaaagg acctgatgga  1920
tttgaatact ttgcacctgc taatacagat gctaacaata tagaaggtca agctatacgt  1980
tatcaaaata gattcctata tttacatgac aatatatatt attttggtaa taattcaaaa  2040
gcagctactg gttgggtaac tattgatggt aatagatatt acttcgagcc taatacagct  2100
atgggtgcga atggttataa aactattgat aataaaaatt tttactttag aaatggttta  2160
cctcagatag gagtgtttaa agggtctaat ggatttgaat actttgcacc tgctaatacg  2220
gatgctaaca atatagaagg tcaagctata cgttatcaaa atagattcct acatttactt  2280
ggaaaaatat attactttgg taataattca aaagcagtta ctggatggca aactattaat  2340
ggtaaagtat attactttat gcctgatact gctatggctg cagctggtgg acttttcgag  2400
attgatggtg ttatatattt ctttggtgtt gatggagtaa aagcccct               2448

<210>   46
<211>   2301
<212>   DNA
<213>   Clostridium difficile

<400>   46
atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtactcaa  60
gaagatgaat atgttgcaat attggatgct ttagaagaat atcataatat gtcagagaat  120
actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tatttatata  180
gatacatata aaaaatctgg tagaaataaa gccttaaaaa aatttaagga atatctagtt  240
acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt  300
gtttggattg gaggtcaaat aaatgacact gctattaatt atataaatca atggaaagat  360
gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca  420
ttgaaaaaaa ctgtagtaga atcagcaata aatgatacac ttgaatcatt tagagaaaac  480
ttaaatgacc ctagatttga ctataataaa ttcttcagaa aacgtatgga aataatttat  540
gataaacaga aaaatttcat aaactactat aaagctcaaa gagaagaaaa tcctgaactt  600
ataattgatg atattgtaaa gacatatctt tcaaatgagt attcaaagga gatagatgaa  660
cttaatacct atattgaaga atccttaaat aaaattacac agaatagtgg aaatgatgtt  720
agaaactttg aagaatttaa aaatggagag tcattcaact tatatgaaca agagttggta  780
gaaaggtgga atttagctgc tgcttctgac atattaagaa tatctgcatt aaaagaaatt  840
ggtggtatgt atttagatgt tgatatgtta ccaggaatac aaccagactt atttgagtct  900
atagagaaac ctagttcagt aacagtggat ttttgggaaa tgacaaagtt agaagctata  960
atgaaataca aagaatatat accagaatat acctcagaac attttgacat gttagacgaa  1020
gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataaatc agaaatattc  1080
tcatcacttg gtgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaag  1140
ggtattataa atcaagggct aatttctgtg aaagactcat attgtagcaa tttaatagta  1200
aaacaaatcg agaatagata taaaatattg aataatagtt taaatccagc tattagcgag  1260
gataatgatt ttaatactac aacgaatacc tttattgata gtataatggc tgaagctaat  1320
gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca  1380
gatgttaaaa ctactattaa cttaagtggc cctgaagcat atgcggcagc ttatcaagat  1440
ttattaatgt ttaaagaagg cagtatgaat atccatttga tagaagctga tttaagaaac  1500
tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc tagcttatgg  1560
tcatttgacg atgcaagagc taaagctcaa tttgaagaat ataaaaggaa ttattttgaa  1620
ggttctcttg gtgaagatga taatcttgat ttttctcaaa atatagtagt tgacaaggag  1680
tatcttttag aaaaaatatc ttcattagca agaagttcag agagaggata tatacactat  1740
attgttcagt tacaaggaga taaaattagt tatgaagcag catgtaactt atttgcaaag  1800
actccttatg atagtgtact gtttcagaaa aatatagaag attcagaaat tgcatattat  1860
tataatcctg gagatggtga aatacaagaa atagacaagt ataaaattcc aagtataatt  1920
tctgatagac ctaagattaa attaacattt attggtcatg gtaaagatga atttaatact  1980
gatatatttg caggttttga tgtagattca ttatccacag aaatagaagc agcaatagat  2040
ttagctaaag aggatatttc tcctaagtca atagaaataa atttattagg atgtaatatg  2100
tttagctact ctatcaacgt agaggagact tatcctggaa aattattact taaagttaaa  2160
gataaaatat cagaattaat gccatctata agtcaagact ctattatagt aagtgcaaat  2220
caatatgaag ttagaataaa tagtgaagga agaagagaat tattggatca ttctggtgaa  2280
tggataaata aagaagaaag t                                            2301

<210>   47
<211>   1629
<212>   DNA
<213>   Clostridium difficile

<400>   47
atgagtttag ttaatagaaa acagttagaa aaaatggcaa atgtaagatt tcgtactcaa  60
gaagatgaat atgttgcaat attggatgct ttagaagaat atcataatat gtcagagaat  120
actgtagtcg aaaaatattt aaaattaaaa gatataaata gtttaacaga tatttatata  180
gatacatata aaaaatctgg tagaaataaa gccttaaaaa aatttaagga atatctagtt  240
acagaagtat tagagctaaa gaataataat ttaactccag ttgagaaaaa tttacatttt  300
gtttggattg gaggtcaaat aaatgacact gctattaatt atataaatca atggaaagat  360
gtaaatagtg attataatgt taatgttttt tatgatagta atgcattttt gataaacaca  420
ttgaaaaaaa ctgtagtaga atcagcaata aatgatacac ttgaatcatt tagagaaaac  480
ttaaatgacc ctagatttga ctataataaa ttcttcagaa aacgtatgga aataatttat  540
gataaacaga aaaatttcat aaactactat aaagctcaaa gagaagaaaa tcctgaactt  600
ataattgatg atattgtaaa gacatatctt tcaaatgagt attcaaagga gatagatgaa  660
cttaatacct atattgaaga atccttaaat aaaattacac agaatagtgg aaatgatgtt  720
agaaactttg aagaatttaa aaatggagag tcattcaact tatatgaaca agagttggta  780
gaaaggtgga atttagctgc tgcttctgac atattaagaa tatctgcatt aaaagaaatt  840
ggtggtatgt atttagatgt tgatatgtta ccaggaatac aaccagactt atttgagtct  900
atagagaaac ctagttcagt aacagtggat ttttgggaaa tgacaaagtt agaagctata  960
atgaaataca aagaatatat accagaatat acctcagaac attttgacat gttagacgaa  1020
gaagttcaaa gtagttttga atctgttcta gcttctaagt cagataaatc agaaatattc  1080
tcatcacttg gtgatatgga ggcatcacca ctagaagtta aaattgcatt taatagtaag  1140
ggtattataa atcaagggct aatttctgtg aaagactcat attgtagcaa tttaatagta  1200
aaacaaatcg agaatagata taaaatattg aataatagtt taaatccagc tattagcgag  1260
gataatgatt ttaatactac aacgaatacc tttattgata gtataatggc tgaagctaat  1320
gcagataatg gtagatttat gatggaacta ggaaagtatt taagagttgg tttcttccca  1380
gatgttaaaa ctactattaa cttaagtggc cctgaagcat atgcggcagc ttatcaagat  1440
ttattaatgt ttaaagaagg cagtatgaat atccatttga tagaagctga tttaagaaac  1500
tttgaaatct ctaaaactaa tatttctcaa tcaactgaac aagaaatggc tagcttatgg  1560
tcatttgacg atgcaagagc taaagctcaa tttgaagaat ataaaaggaa ttattttgaa  1620
ggttctctt                                                          1629

<210>   48
<211>   672
<212>   DNA
<213>   Clostridium difficile

<400>   48
ggtgaagatg ataatcttga tttttctcaa aatatagtag ttgacaagga gtatctttta  60
gaaaaaatat cttcattagc aagaagttca gagagaggat atatacacta tattgttcag  120
ttacaaggag ataaaattag ttatgaagca gcatgtaact tatttgcaaa gactccttat  180
gatagtgtac tgtttcagaa aaatatagaa gattcagaaa ttgcatatta ttataatcct  240
ggagatggtg aaatacaaga aatagacaag tataaaattc caagtataat ttctgataga  300
cctaagatta aattaacatt tattggtcat ggtaaagatg aatttaatac tgatatattt  360
gcaggttttg atgtagattc attatccaca gaaatagaag cagcaataga tttagctaaa  420
gaggatattt ctcctaagtc aatagaaata aatttattag gatgtaatat gtttagctac  480
tctatcaacg tagaggagac ttatcctgga aaattattac ttaaagttaa agataaaata  540
tcagaattaa tgccatctat aagtcaagac tctattatag taagtgcaaa tcaatatgaa  600
gttagaataa atagtgaagg aagaagagaa ttattggatc attctggtga atggataaat  660
aaagaagaaa gt                                                      672

<210>   49
<211>   3198
<212>   DNA
<213>   Clostridium difficile

<400>   49
attataaagg atatttcatc aaaagaatat atatcattta atcctaaaga aaataaaatt  60
acagtaaaat ctaaaaattt acctgagcta tctacattat tacaagaaat tagaaataat  120
tctaattcaa gtgatattga actagaagaa aaagtaatgt taacagaatg tgagataaat  180
gttatttcaa atatagatac gcaaattgtt gaggaaagga ttgaagaagc taagaattta  240
acttctgact ctattaatta tataaaagat gaatttaaac taatagaatc tatttctgat  300
gcactatgtg acttaaaaca acagaatgaa ttagaagatt ctcattttat atcttttgag  360
gacatatcag agactgatga gggatttagt ataagattta ttaataaaga aactggagaa  420
tctatatttg tagaaactga aaaaacaata ttctctgaat atgctaatca tataactgaa  480
gagatttcta agataaaagg tactatattt gatactgtaa atggtaagtt agtaaaaaaa  540
gtaaatttag atactacaca cgaagtaaat actttaaatg ctgcattttt tatacaatca  600
ttaatagaat ataatagttc taaagaatct cttagtaatt taagtgtagc aatgaaagtc  660
caagtttacg ctcaattatt tagtactggt ttaaatacta ttacagatgc agccaaagtt  720
gttgaattag tatcaactgc attagatgaa actatagact tacttcctac attatctgaa  780
ggattaccta taattgcaac tattatagat ggtgtaagtt taggtgcagc aatcaaagag  840
ctaagtgaaa cgagtgaccc attattaaga caagaaatag aagctaagat aggtataatg  900
gcagtaaatt taacaacagc tacaactgca atcattactt catctttggg gatagctagt  960
ggatttagta tacttttagt tcctttagca ggaatttcag caggtatacc aagcttagta  1020
aacaatgaac ttgtacttcg agataaggca acaaaggttg tagattattt taaacatgtt  1080
tcattagttg aaactgaagg agtatttact ttattagatg ataaaataat gatgccacaa  1140
gatgatttag tgatatcaga aatagatttt aataataatt caatagtttt aggtaaatgt  1200
gaaatctgga gaatggaagg tggttcaggt catactgtaa ctgatgatat agatcacttc  1260
ttttcagcac catcaataac atatagagag ccacacttat ctatatatga cgtattggaa  1320
gtacaaaaag aagaacttga tttgtcaaaa gatttaatgg tattacctaa tgctccaaat  1380
agagtatttg cttgggaaac aggatggaca ccaggtttaa gaagcttaga aaatgatggc  1440
acaaaactgt tagaccgtat aagagataac tatgaaggtg agttttattg gagatatttt  1500
gcttttatag ctgatgcttt aataacaaca ttaaaaccaa gatatgaaga tactaatata  1560
agaataaatt tagatagtaa tactagaagt tttatagttc caataataac tacagaatat  1620
ataagagaaa aattatcata ttctttctat ggttcaggag gaacttatgc attgtctctt  1680
tctcaatata atatgggtat aaatatagaa ttaagtgaaa gtgatgtttg gattatagat  1740
gttgataatg ttgtgagaga tgtaactata gaatctgata aaattaaaaa aggtgattta  1800
atagaaggta ttttatctac actaagtatt gaagagaata aaattatctt aaatagccat  1860
gagattaatt tttctggtga ggtaaatgga agtaatggat ttgtttcttt aacattttca  1920
attttagaag gaataaatgc aattatagaa gttgatttat tatctaaatc atataaatta  1980
cttatttctg gcgaattaaa aatattgatg ttaaattcaa atcatattca acagaaaata  2040
gattatatag gattcaatag cgaattacag aaaaatatac catatagctt tgtagatagt  2100
gaaggaaaag agaatggttt tattaatggt tcaacaaaag aaggtttatt tgtatctgaa  2160
ttacctgatg tagttcttat aagtaaggtt tatatggatg atagtaagcc ttcatttgga  2220
tattatagta ataatttgaa agatgtcaaa gttataacta aagataatgt taatatatta  2280
acaggttatt atcttaagga tgatataaaa atctctcttt ctttgactct acaagatgaa  2340
aaaactataa agttaaatag tgtgcattta gatgaaagtg gagtagctga gattttgaag  2400
ttcatgaata gaaaaggtaa tacaaatact tcagattctt taatgagctt tttagaaagt  2460
atgaatataa aaagtatttt cgttaatttc ttacaatcta atattaagtt tatattagat  2520
gctaatttta taataagtgg tactacttct attggccaat ttgagtttat ttgtgatgaa  2580
aatgataata tacaaccata tttcattaag tttaatacac tagaaactaa ttatacttta  2640
tatgtaggaa atagacaaaa tatgatagtg gaaccaaatt atgatttaga tgattctgga  2700
gatatatctt caactgttat caatttctct caaaagtatc tttatggaat agacagttgt  2760
gttaataaag ttgtaatttc accaaatatt tatacagatg aaataaatat aacgcctgta  2820
tatgaaacaa ataatactta tccagaagtt attgtattag atgcaaatta tataaatgaa  2880
aaaataaatg ttaatatcaa tgatctatct atacgatatg tatggagtaa tgatggtaat  2940
gattttattc ttatgtcaac tagtgaagaa aataaggtgt cacaagttaa aataagattc  3000
gttaatgttt ttaaagataa gactttggca aataagctat cttttaactt tagtgataaa  3060
caagatgtac ctgtaagtga aataatctta tcatttacac cttcatatta tgaggatgga  3120
ttgattggct atgatttggg tctagtttct ttatataatg agaaatttta tattaataac  3180
tttggaatga tggtatct                                                3198

<210>   50
<211>   1545
<212>   DNA
<213>   Clostridium difficile

<400>   50
ataactggat ttgtgactgt aggcgatgat aaatactact ttaatccaat taatggtgga  60
gctgcttcaa ttggagagac aataattgat gacaaaaatt attatttcaa ccaaagtgga  120
gtgttacaaa caggtgtatt tagtacagaa gatggattta aatattttgc cccagctaat  180
acacttgatg aaaacctaga aggagaagca attgatttta ctggaaaatt aattattgac  240
gaaaatattt attattttga tgataattat agaggagctg tagaatggaa agaattagat  300
ggtgaaatgc actattttag cccagaaaca ggtaaagctt ttaaaggtct aaatcaaata  360
ggtgattata aatactattt caattctgat ggagttatgc aaaaaggatt tgttagtata  420
aatgataata aacactattt tgatgattct ggtgttatga aagtaggtta cactgaaata  480
gatggcaagc atttctactt tgctgaaaac ggagaaatgc aaataggagt atttaataca  540
gaagatggat ttaaatattt tgctcatcat aatgaagatt taggaaatga agaaggtgaa  600
gaaatctcat attctggtat attaaatttc aataataaaa tttactattt tgatgattca  660
tttacagctg tagttggatg gaaagattta gaggatggtt caaagtatta ttttgatgaa  720
gatacagcag aagcatatat aggtttgtca ttaataaatg atggtcaata ttattttaat  780
gatgatggaa ttatgcaagt tggatttgtc actataaatg ataaagtctt ctacttctct  840
gactctggaa ttatagaatc tggagtacaa aacatagatg acaattattt ctatatagat  900
gataatggta tagttcaaat tggtgtattt gatacttcag atggatataa atattttgca  960
cctgctaata ctgtaaatga taatatttac ggacaagcag ttgaatatag tggtttagtt  1020
agagttggtg aagatgtata ttattttgga gaaacatata caattgagac tggatggata  1080
tatgatatgg aaaatgaaag tgataaatat tatttcaatc cagaaactaa aaaagcatgc  1140
aaaggtatta atttaattga tgatataaaa tattattttg atgagaaggg cataatgaga  1200
acgggtctta tatcatttga aaataataat tattacttta atgagaatgg tgaaatgcaa  1260
tttggttata taaatataga agataagatg ttctattttg gtgaagatgg tgtcatgcag  1320
attggagtat ttaatacacc agatggattt aaatactttg cacatcaaaa tactttggat  1380
gagaattttg agggagaatc aataaactat actggttggt tagatttaga tgaaaagaga  1440
tattatttta cagatgaata tattgcagca actggttcag ttattattga tggtgaggag  1500
tattattttg atcctgatac agctcaatta gtgattagtg aatag                  1545

<210>   51
<211>   633
<212>   DNA
<213>   Clostridium difficile

<400>   51
gttcaaattg gtgtatttga tacttcagat ggatataaat attttgcacc tgctaatact  60
gtaaatgata atatttacgg acaagcagtt gaatatagtg gtttagttag agttggtgaa  120
gatgtatatt attttggaga aacatataca attgagactg gatggatata tgatatggaa  180
aatgaaagtg ataaatatta tttcaatcca gaaactaaaa aagcatgcaa aggtattaat  240
ttaattgatg atataaaata ttattttgat gagaagggca taatgagaac gggtcttata  300
tcatttgaaa ataataatta ttactttaat gagaatggtg aaatgcaatt tggttatata  360
aatatagaag ataagatgtt ctattttggt gaagatggtg tcatgcagat tggagtattt  420
aatacaccag atggatttaa atactttgca catcaaaata ctttggatga gaattttgag  480
ggagaatcaa taaactatac tggttggtta gatttagatg aaaagagata ttattttaca  540
gatgaatata ttgcagcaac tggttcagtt attattgatg gtgaggagta ttattttgat  600
cctgatacag ctcaattagt gattagtgaa tag                               633

<210>   52
<211>   933
<212>   DNA
<213>   Clostridium difficile

<400>   52
tattctggta tattaaattt caataataaa atttactatt ttgatgattc atttacagct  60
gtagttggat ggaaagattt agaggatggt tcaaagtatt attttgatga agatacagca  120
gaagcatata taggtttgtc attaataaat gatggtcaat attattttaa tgatgatgga  180
attatgcaag ttggatttgt cactataaat gataaagtct tctacttctc tgactctgga  240
attatagaat ctggagtaca aaacatagat gacaattatt tctatataga tgataatggt  300
atagttcaaa ttggtgtatt tgatacttca gatggatata aatattttgc acctgctaat  360
actgtaaatg ataatattta cggacaagca gttgaatata gtggtttagt tagagttggt  420
gaagatgtat attattttgg agaaacatat acaattgaga ctggatggat atatgatatg  480
gaaaatgaaa gtgataaata ttatttcaat ccagaaacta aaaaagcatg caaaggtatt  540
aatttaattg atgatataaa atattatttt gatgagaagg gcataatgag aacgggtctt  600
atatcatttg aaaataataa ttattacttt aatgagaatg gtgaaatgca atttggttat  660
ataaatatag aagataagat gttctatttt ggtgaagatg gtgtcatgca gattggagta  720
tttaatacac cagatggatt taaatacttt gcacatcaaa atactttgga tgagaatttt  780
gagggagaat caataaacta tactggttgg ttagatttag atgaaaagag atattatttt  840
acagatgaat atattgcagc aactggttca gttattattg atggtgagga gtattatttt  900
gatcctgata cagctcaatt agtgattagt gaa                               933

<210>   53
<211>   2616
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   B4 hybrid

<400>   53
catatgagtc tggttaaccg taaacaactg gaaaaaatgg cgaatgtgcg ctttagaacc  60
caggaagatg aatatgttgc gattctagat gcactggaag aataccataa catgtcagag  120
aataccgtgg tagaaaaata tctgaaactg aaagatatta actctctgac ggatatctat  180
attgacacgt acaaaaaaag cggtcgtaat aaagctctga aaaaatttaa ggaatatctc  240
gttacggaag tgctggagct caagaacaat aacctgaccc cggttgagaa aaatctgcat  300
ttcgtttgga tcggcggtca gattaacgac accgccatca attacattaa ccagtggaaa  360
gatgtgaata gcgattataa cgttaatgtc ttttatgact cgaacgcgtt tctaattaac  420
acgctaaaaa aaaccgtggt ggaaagcgcg attaatgata ctcttgagag ctttcgcgaa  480
aacctgaacg acccacgttt cgactacaat aaattcttcc gcaaaagaat ggaaattatc  540
tatgataaac aaaaaaactt cattaactac tataaagcac aacgtgaaga aaatccggaa  600
ctgattatcg acgatatcgt gaagacgtac ttgagcaacg agtatagcaa ggagattgat  660
gaacttaata catacatcga agaatcactg aacaaaatca cgcaaaatag tggcaacgac  720
gttcgcaact ttgaggaatt taaaaatggc gagagcttca acttatatga acaggagcta  780
gtggaacgat ggaacctggc cgcagcctcc gcgattctgg cgatttctgc gctgaaagaa  840
atcggtggta tggcgctggc ggtcgcgatg ctgccgggca ttcagccgga cctgtttgag  900
tccattgaga aacctagtag cgtgacggta gacttctggg aaatgacgaa gttagaagca  960
attatgaaat acaaagaata tattccggaa tacacaagcg aacactttga catgctggac  1020
gaggaagttc agtcgagctt tgaatctgtc ctcgccagca agagcgataa aagcgaaatt  1080
ttcagcagcc tgggtgatat ggaggcgagc ccgctcgaag ttaaaatcgc gtttaattcg  1140
aagggtatca ttaaccaagg actcatctcc gtaaaagaca gctattgttc aaatctgatt  1200
gtgaaacaga tagagaaccg ctataaaatt ctaaataaca gtctgaatcc ggcaatctca  1260
gaggacaacg atttcaatac cactacaaac acatttatcg atagtattat ggccgaagca  1320
aatgcggaca acggtcgttt tatgatggaa ctcggtaagt acctgcgcgt cggtttcttc  1380
ccggatgtta aaaccaccat caacttatcg ggaccagaag cgtatgctgc ggcctaccag  1440
gatctgctga tgtttaaaga aggaagcatg aatatacatc taattgaagc agacctgcgt  1500
aacttcgaga tatctaaaac caacatctcc caaagcaccg aacaggaaat ggcctcactg  1560
tggagctttg acgatgcgcg cgcaaaagcc cagtttgaag aatataaacg aaattacttt  1620
gaaggtagct tgggatccgg agggggtggt gctagcaccg gttatacttc gatcaacggt  1680
aaacattttt actttaatac cgacggtatc atgcaaattg gcgtattcaa aggtcctaac  1740
ggctttgaat actttgcgcc agcaaatacc cacaacaata acattgaagg tcaggccatt  1800
ctgtaccaaa acaaattcct gaccctaaat ggtaaaaaat attacttcgg tagtgacagc  1860
aaagcggtta caggcctaag gaccatcgat ggtaaaaaat attactttaa caccaacacc  1920
gcagtcgcgg ttaccggctg gcagaccatc aatggtaaaa aatactactt taacaccaac  1980
acctctattg ccagcaccgg ttacacgatc atctcgggta aacatttcta ttttaatacc  2040
gatggtatca tgcaaattgg cgtatttaaa ggtccggacg gcttcgaata ctttgcgcct  2100
gcaaacacgg atgccaacaa tattgagggt caggcaatta gatatcaaaa ccgcttcctc  2160
tacctgcatg acaatattta ttactttggt aacaatagca aagcggccac cggttgggtg  2220
accatcgatg gtaaccgtta ttacttcgag ccaaatacgg caatgggtgc taacggttat  2280
aaaaccatcg acaataaaaa cttctacttt cgcaatggtc tgccgcaaat tggcgtattt  2340
aaaggatcta acggcttcga atactttgcg cctgccaata cagatgcaaa caacattgaa  2400
ggtcaggcca ttagatacca aaatcgtttc ctccatttac ttggcaaaat ttattacttt  2460
ggtaacaata gcaaagcggt caccggttgg caaaccatca acggtaaagt gtattacttt  2520
atgccagata ccgcaatggc cgcggcaggt ggcttgttcg agatcgacgg tgttatttac  2580
ttcttcggtg tcgatggcgt gaaagctccg ctcgag                            2616

<210>   54
<211>   769
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   54
Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr 
    50                  55                  60                  

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg 
    210                 215                 220                 

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met 
        275                 280                 285             

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser 
    290                 295                 300                 

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser Leu Ser Glu 
    530                 535                 540                 

Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp Lys Asn Tyr 
545                 550                 555                 560 

Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu Ala Gly Ser 
                565                 570                 575     

Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asp Asp Ile Ser 
            580                 585                 590         

Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys Asn Ser Ile 
        595                 600                 605             

Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr Phe Leu Ser 
    610                 615                 620                 

Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg Ile Pro Glu 
625                 630                 635                 640 

Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile Gly His Gly 
                645                 650                 655     

Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser Val Asp Ser 
            660                 665                 670         

Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys Leu Asp Ile 
        675                 680                 685             

Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Cys Asn Met Phe Ser 
    690                 695                 700                 

Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Ser 
705                 710                 715                 720 

Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn Lys Asn Ser 
                725                 730                 735     

Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
            740                 745                 750         

Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn Lys Glu Glu 
        755                 760                 765             

Ala 
    

<210>   55
<211>   2307
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   55
atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa  60
aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat  120
aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat  180
aaatataaaa cttcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa  240
gaagtaattc ttattaaaaa ttccaataca agccctgtag aaaaaaattt acattttgta  300
tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt  360
aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt aaatacacta  420
aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt  480
caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat  540
agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca  600
atagatgata ttataaagtc tcatctagta tctgaatata atagagatga aactgtatta  660
gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg  720
gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat  780
cgtggaaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc  840
ggagtagcct tagccgttgc catgcttcca ggtattcact ctgatttatt taaaacaata  900
tctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg  960
aagtataaaa aatatataaa taattataca tcagaaaact ttgataaact tgatcaacaa  1020
ttaaaagata attttaaact cattatagaa agtaaaagtg aaaaatctga gatattttct  1080
aaattagaaa atttaaatgt atctgatctt gaaattaaaa tagctttcgc tttaggcagt  1140
gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa  1200
caagtaaaaa atagatatca atttttaaac caacacctta acccagccat agagtctgat  1260
aataacttca cagatactac taaaattttt catgattcat tatttaattc agctaccgca  1320
gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa  1380
gctcgctcca caataagttt aagtggtcca ggagcttatg cgtcagctta ctatgatttc  1440
ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt  1500
aaattcccag aaaataatct atctcaattg acagaacaag aaataaatag tctatggagc  1560
tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga  1620
tctctttctg aagacaatgg ggtagacttt aataaaaata ctgccctcga caaaaactat  1680
ttattaaata ataaaattcc atcaaacaat gtagaagaag ctggaagtaa aaattatgtt  1740
cattatatca tacagttaca aggagatgat ataagttatg aagcaacatg caatttattt  1800
tctaaaaatc ctaaaaatag tattattata caacgaaata tgaatgaaag tgcaaaaagc  1860
tactttttaa gtgatgatgg agaatctatt ttagaattaa ataaatatag gatacctgaa  1920
agattaaaaa ataaggaaaa agtaaaagta acctttattg gacatggtaa agatgaattc  1980
aacacaagcg aatttgctag attaagtgta gattcacttt ccaatgagat aagttcattt  2040
ttagatacca taaaattaga tatatcacct aaaaatgtag aagtaaactt acttggatgt  2100
aatatgttta gttatgattt taatgttgaa gaaacttatc ctgggaagtt gctattaagt  2160
attatggaca aaattacttc cactttacct gatgtaaata aaaattctat tactatagga  2220
gcaaatcaat atgaagtaag aattaatagt gagggaagaa aagaacttct ggctcactca  2280
ggtaaatgga taaataaaga agaagct                                      2307

<210>   56
<211>   541
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   56
Met Ser Leu Ile Ser Lys Glu Glu Leu Ile Lys Leu Ala Tyr Ser Ile 
1               5                   10                  15      

Arg Pro Arg Glu Asn Glu Tyr Lys Thr Ile Leu Thr Asn Leu Asp Glu 
            20                  25                  30          

Tyr Asn Lys Leu Thr Thr Asn Asn Asn Glu Asn Lys Tyr Leu Gln Leu 
        35                  40                  45              

Lys Lys Leu Asn Glu Ser Ile Asp Val Phe Met Asn Lys Tyr Lys Thr 
    50                  55                  60                  

Ser Ser Arg Asn Arg Ala Leu Ser Asn Leu Lys Lys Asp Ile Leu Lys 
65                  70                  75                  80  

Glu Val Ile Leu Ile Lys Asn Ser Asn Thr Ser Pro Val Glu Lys Asn 
                85                  90                  95      

Leu His Phe Val Trp Ile Gly Gly Glu Val Ser Asp Ile Ala Leu Glu 
            100                 105                 110         

Tyr Ile Lys Gln Trp Ala Asp Ile Asn Ala Glu Tyr Asn Ile Lys Leu 
        115                 120                 125             

Trp Tyr Asp Ser Glu Ala Phe Leu Val Asn Thr Leu Lys Lys Ala Ile 
    130                 135                 140                 

Val Glu Ser Ser Thr Thr Glu Ala Leu Gln Leu Leu Glu Glu Glu Ile 
145                 150                 155                 160 

Gln Asn Pro Gln Phe Asp Asn Met Lys Phe Tyr Lys Lys Arg Met Glu 
                165                 170                 175     

Phe Ile Tyr Asp Arg Gln Lys Arg Phe Ile Asn Tyr Tyr Lys Ser Gln 
            180                 185                 190         

Ile Asn Lys Pro Thr Val Pro Thr Ile Asp Asp Ile Ile Lys Ser His 
        195                 200                 205             

Leu Val Ser Glu Tyr Asn Arg Asp Glu Thr Val Leu Glu Ser Tyr Arg 
    210                 215                 220                 

Thr Asn Ser Leu Arg Lys Ile Asn Ser Asn His Gly Ile Asp Ile Arg 
225                 230                 235                 240 

Ala Asn Ser Leu Phe Thr Glu Gln Glu Leu Leu Asn Ile Tyr Ser Gln 
                245                 250                 255     

Glu Leu Leu Asn Arg Gly Asn Leu Ala Ala Ala Ser Asp Ile Val Arg 
            260                 265                 270         

Leu Leu Ala Leu Lys Asn Phe Gly Gly Val Ala Leu Ala Val Ala Met 
        275                 280                 285             

Leu Pro Gly Ile His Ser Asp Leu Phe Lys Thr Ile Ser Arg Pro Ser 
    290                 295                 300                 

Ser Ile Gly Leu Asp Arg Trp Glu Met Ile Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 

Lys Tyr Lys Lys Tyr Ile Asn Asn Tyr Thr Ser Glu Asn Phe Asp Lys 
                325                 330                 335     

Leu Asp Gln Gln Leu Lys Asp Asn Phe Lys Leu Ile Ile Glu Ser Lys 
            340                 345                 350         

Ser Glu Lys Ser Glu Ile Phe Ser Lys Leu Glu Asn Leu Asn Val Ser 
        355                 360                 365             

Asp Leu Glu Ile Lys Ile Ala Phe Ala Leu Gly Ser Val Ile Asn Gln 
    370                 375                 380                 

Ala Leu Ile Ser Lys Gln Gly Ser Tyr Leu Thr Asn Leu Val Ile Glu 
385                 390                 395                 400 

Gln Val Lys Asn Arg Tyr Gln Phe Leu Asn Gln His Leu Asn Pro Ala 
                405                 410                 415     

Ile Glu Ser Asp Asn Asn Phe Thr Asp Thr Thr Lys Ile Phe His Asp 
            420                 425                 430         

Ser Leu Phe Asn Ser Ala Thr Ala Glu Asn Ser Met Phe Leu Thr Lys 
        435                 440                 445             

Ile Ala Pro Tyr Leu Gln Val Gly Phe Met Pro Glu Ala Arg Ser Thr 
    450                 455                 460                 

Ile Ser Leu Ser Gly Pro Gly Ala Tyr Ala Ser Ala Tyr Tyr Asp Phe 
465                 470                 475                 480 

Ile Asn Leu Gln Glu Asn Thr Ile Glu Lys Thr Leu Lys Ala Ser Asp 
                485                 490                 495     

Leu Ile Glu Phe Lys Phe Pro Glu Asn Asn Leu Ser Gln Leu Thr Glu 
            500                 505                 510         

Gln Glu Ile Asn Ser Leu Trp Ser Phe Asp Gln Ala Ser Ala Lys Tyr 
        515                 520                 525             

Gln Phe Glu Lys Tyr Val Arg Asp Tyr Thr Gly Gly Ser 
    530                 535                 540     

<210>   57
<211>   1623
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   57
atgtctttaa tatctaaaga agagttaata aaactcgcat atagcattag accaagagaa  60
aatgagtata aaactatact aactaattta gacgaatata ataagttaac tacaaacaat  120
aatgaaaata aatatttaca attaaaaaaa ctaaatgaat caattgatgt ttttatgaat  180
aaatataaaa cttcaagcag aaatagagca ctctctaatc taaaaaaaga tatattaaaa  240
gaagtaattc ttattaaaaa ttccaataca agccctgtag aaaaaaattt acattttgta  300
tggataggtg gagaagtcag tgatattgct cttgaataca taaaacaatg ggctgatatt  360
aatgcagaat ataatattaa actgtggtat gatagtgaag cattcttagt aaatacacta  420
aaaaaggcta tagttgaatc ttctaccact gaagcattac agctactaga ggaagagatt  480
caaaatcctc aatttgataa tatgaaattt tacaaaaaaa ggatggaatt tatatatgat  540
agacaaaaaa ggtttataaa ttattataaa tctcaaatca ataaacctac agtacctaca  600
atagatgata ttataaagtc tcatctagta tctgaatata atagagatga aactgtatta  660
gaatcatata gaacaaattc tttgagaaaa ataaatagta atcatgggat agatatcagg  720
gctaatagtt tgtttacaga acaagagtta ttaaatattt atagtcagga gttgttaaat  780
cgtggaaatt tagctgcagc atctgacata gtaagattat tagccctaaa aaattttggc  840
ggagtagcct tagccgttgc catgcttcca ggtattcact ctgatttatt taaaacaata  900
tctagaccta gctctattgg actagaccgt tgggaaatga taaaattaga ggctattatg  960
aagtataaaa aatatataaa taattataca tcagaaaact ttgataaact tgatcaacaa  1020
ttaaaagata attttaaact cattatagaa agtaaaagtg aaaaatctga gatattttct  1080
aaattagaaa atttaaatgt atctgatctt gaaattaaaa tagctttcgc tttaggcagt  1140
gttataaatc aagccttgat atcaaaacaa ggttcatatc ttactaacct agtaatagaa  1200
caagtaaaaa atagatatca atttttaaac caacacctta acccagccat agagtctgat  1260
aataacttca cagatactac taaaattttt catgattcat tatttaattc agctaccgca  1320
gaaaactcta tgtttttaac aaaaatagca ccatacttac aagtaggttt tatgccagaa  1380
gctcgctcca caataagttt aagtggtcca ggagcttatg cgtcagctta ctatgatttc  1440
ataaatttac aagaaaatac tatagaaaaa actttaaaag catcagattt aatagaattt  1500
aaattcccag aaaataatct atctcaattg acagaacaag aaataaatag tctatggagc  1560
tttgatcaag caagtgcaaa atatcaattt gagaaatatg taagagatta tactggtgga  1620
tct                                                                1623

<210>   58
<211>   766
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   58
Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe 
1               5                   10                  15      

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu 
            20                  25                  30          

Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys Leu 
        35                  40                  45              

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys 
    50                  55                  60                  

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr 
65                  70                  75                  80  

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn 
                85                  90                  95      

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn 
            100                 105                 110         

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val 
        115                 120                 125             

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val 
    130                 135                 140                 

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu 
145                 150                 155                 160 

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu 
                165                 170                 175     

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln 
            180                 185                 190         

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr 
        195                 200                 205             

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile 
    210                 215                 220                 

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg 
225                 230                 235                 240 

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln 
                245                 250                 255     

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala 
            260                 265                 270         

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met 
        275                 280                 285             

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser 
    290                 295                 300                 

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met 
                325                 330                 335     

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys 
            340                 345                 350         

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser 
        355                 360                 365             

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln 
    370                 375                 380                 

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys 
385                 390                 395                 400 

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala 
                405                 410                 415     

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp 
            420                 425                 430         

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu 
        435                 440                 445             

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr 
    450                 455                 460                 

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu 
465                 470                 475                 480 

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp 
                485                 490                 495     

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu 
            500                 505                 510         

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala 
        515                 520                 525             

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly Glu 
    530                 535                 540                 

Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu Tyr 
545                 550                 555                 560 

Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly Tyr 
                565                 570                 575     

Ile His Tyr Ile Val Gln Leu Gln Gly Asn Lys Ile Ser Tyr Glu Ala 
            580                 585                 590         

Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe Gln 
        595                 600                 605             

Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly Asp 
    610                 615                 620                 

Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile Ser 
625                 630                 635                 640 

Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Ala Gly Lys Asp Glu 
                645                 650                 655     

Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser Thr 
            660                 665                 670         

Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro Lys 
        675                 680                 685             

Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser Ile 
    690                 695                 700                 

Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys Asp 
705                 710                 715                 720 

Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile Val 
                725                 730                 735     

Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg Glu 
            740                 745                 750         

Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser 
        755                 760                 765     

<210>   59
<211>   2303
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   59
ggcagtctgg ttaaccgtaa acaactggaa aaaatggcga atgtgcgctt tagaacccag  60
gaagatgaat atgttgcgat tctagatgca ctggaagaat accataacat gtcagagaat  120
accgtggtag aaaaatatct gaaactgaaa gatattaact ctctgacgga tatctatatt  180
gacacgtaca aaaaaagcgg tcgtaataaa gctctgaaaa aatttaagga atatctcgtt  240
acggaagtgc tggagctcaa gaacaataac ctgaccccgg ttgagaaaaa tctgcatttc  300
gtttggatcg gcggtcagat taacgacacc gccatcaatt acattaacca gtggaaagat  360
gtgaatagcg attataacgt taatgtcttt tatgactcga acgcgtttct aattaacacg  420
ctaaaaaaaa ccgtggtgga aagcgcgatt aatgatactc ttgagagctt tcgcgaaaac  480
ctgaacgacc cacgtttcga ctacaataaa ttcttccgca aaagaatgga aattatctat  540
gataaacaaa aaaacttcat taactactat aaagcacaac gtgaagaaaa tccggaactg  600
attatcgacg atatcgtgaa gacgtacttg agcaacgagt atagcaagga gattgatgaa  660
cttaatacat acatcgaaga atcactgaac aaaatcacgc aaaatagtgg caacgacgtt  720
cgcaactttg aggaatttaa aaatggcgag agcttcaact tatatgaaca ggagctagtg  780
gaacgatgga acctggccgc agcctccgcg attctggcga tttctgcgct gaaagaaatc  840
ggtggtatgg cgctggcggt cgcgatgctg ccgggcattc agccggacct gtttgagtcc  900
attgagaaac ctagtagcgt gacggtagac ttctgggaaa tgacgaagtt agaagcaatt  960
atgaaataca aagaatatat tccggaatac acaagcgaac actttgacat gctggacgag  1020
gaagttcagt cgagctttga atctgtcctc gccagcaaga gcgataaaag cgaaattttc  1080
agcagcctgg gtgatatgga ggcgagcccg ctcgaagtta aaatcgcgtt taattcgaag  1140
ggtatcatta accaaggact catctccgta aaagacagct attgttcaaa tctgattgtg  1200
aaacagatag agaaccgcta taaaattcta aataacagtc tgaatccggc aatctcagag  1260
gacaacgatt tcaataccac tacaaacaca tttatcgata gtattatggc cgaagcaaat  1320
gcggacaacg gtcgttttat gatggaactc ggtaagtacc tgcgcgtcgg tttcttcccg  1380
gatgttaaaa ccaccatcaa cttatcggga ccagaagcgt atgctgcggc ctaccaggat  1440
ctgctgatgt ttaaagaagg aagcatgaat atacatctaa ttgaagcaga cctgcgtaac  1500
ttcgagatat ctaaaaccaa catctcccaa agcaccgaac aggaaatggc ctcactgtgg  1560
agctttgacg atgcgcgcgc aaaagcccag tttgaagaat ataaacgaaa ttactttgaa  1620
ggtagcttgg gtgaagatga caaccttgat ttctctcaaa atattgtggt cgacaaggag  1680
tatctgctgg aaaaaatttc cagcttagcg cgttcgagcg agcgcggcta tattcactac  1740
atcgttcaac tgcagggcaa caaaatcagt tatgaagcgg cgtgcaacct gtttgcgaag  1800
accccgtatg acagtgtgct atttcaaaaa aacattgaag atagcgagat cgcgtactat  1860
tacaatcctg gcgatggtga aattcaggaa attgacaagt ataaaatccc gtcgattatc  1920
tctgaccgtc caaagatcaa actgacgttt atcggtgcgg gtaaagatga attcaacacc  1980
gatatttttg cgggttttga cgtggatagc ctgtcaacgg aaattgaagc ggcgattgat  2040
ttagcaaaag aggacatctc cccgaagagc attgaaatta atctgctggg cgcgaacatg  2100
ttttcataca gcataaacgt ggaggagacc tatcctggta aactgctgtt gaaagtcaaa  2160
gataaaatta gcgaattaat gccgtctatt agccaagact ccatcattgt gtcggcgaat  2220
cagtacgaag ttcgcattaa cagtgaaggc cgtcgcgagc tgctagatca ttctggtgaa  2280
tggattaata aagaagaaag tgg                                          2303

<210>   60
<211>   542
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   60
Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg Phe 
1               5                   10                  15      

Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu Glu 
            20                  25                  30          

Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys Leu 
        35                  40                  45              

Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys Lys 
    50                  55                  60                  

Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val Thr 
65                  70                  75                  80  

Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys Asn 
                85                  90                  95      

Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile Asn 
            100                 105                 110         

Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn Val 
        115                 120                 125             

Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr Val 
    130                 135                 140                 

Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn Leu 
145                 150                 155                 160 

Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met Glu 
                165                 170                 175     

Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala Gln 
            180                 185                 190         

Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr Tyr 
        195                 200                 205             

Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr Ile 
    210                 215                 220                 

Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val Arg 
225                 230                 235                 240 

Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu Gln 
                245                 250                 255     

Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu Ala 
            260                 265                 270         

Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala Met 
        275                 280                 285             

Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro Ser 
    290                 295                 300                 

Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile Met 
305                 310                 315                 320 

Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp Met 
                325                 330                 335     

Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser Lys 
            340                 345                 350         

Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala Ser 
        355                 360                 365             

Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn Gln 
    370                 375                 380                 

Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val Lys 
385                 390                 395                 400 

Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro Ala 
                405                 410                 415     

Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile Asp 
            420                 425                 430         

Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met Glu 
        435                 440                 445             

Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr Thr 
    450                 455                 460                 

Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp Leu 
465                 470                 475                 480 

Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala Asp 
                485                 490                 495     

Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr Glu 
            500                 505                 510         

Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys Ala 
        515                 520                 525             

Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu 
    530                 535                 540         

<210>   61
<211>   1626
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   61
agtctggtta accgtaaaca actggaaaaa atggcgaatg tgcgctttag aacccaggaa  60
gatgaatatg ttgcgattct agatgcactg gaagaatacc ataacatgtc agagaatacc  120
gtggtagaaa aatatctgaa actgaaagat attaactctc tgacggatat ctatattgac  180
acgtacaaaa aaagcggtcg taataaagct ctgaaaaaat ttaaggaata tctcgttacg  240
gaagtgctgg agctcaagaa caataacctg accccggttg agaaaaatct gcatttcgtt  300
tggatcggcg gtcagattaa cgacaccgcc atcaattaca ttaaccagtg gaaagatgtg  360
aatagcgatt ataacgttaa tgtcttttat gactcgaacg cgtttctaat taacacgcta  420
aaaaaaaccg tggtggaaag cgcgattaat gatactcttg agagctttcg cgaaaacctg  480
aacgacccac gtttcgacta caataaattc ttccgcaaaa gaatggaaat tatctatgat  540
aaacaaaaaa acttcattaa ctactataaa gcacaacgtg aagaaaatcc ggaactgatt  600
atcgacgata tcgtgaagac gtacttgagc aacgagtata gcaaggagat tgatgaactt  660
aatacataca tcgaagaatc actgaacaaa atcacgcaaa atagtggcaa cgacgttcgc  720
aactttgagg aatttaaaaa tggcgagagc ttcaacttat atgaacagga gctagtggaa  780
cgatggaacc tggccgcagc ctccgcgatt ctggcgattt ctgcgctgaa agaaatcggt  840
ggtatggcgc tggcggtcgc gatgctgccg ggcattcagc cggacctgtt tgagtccatt  900
gagaaaccta gtagcgtgac ggtagacttc tgggaaatga cgaagttaga agcaattatg  960
aaatacaaag aatatattcc ggaatacaca agcgaacact ttgacatgct ggacgaggaa  1020
gttcagtcga gctttgaatc tgtcctcgcc agcaagagcg ataaaagcga aattttcagc  1080
agcctgggtg atatggaggc gagcccgctc gaagttaaaa tcgcgtttaa ttcgaagggt  1140
atcattaacc aaggactcat ctccgtaaaa gacagctatt gttcaaatct gattgtgaaa  1200
cagatagaga accgctataa aattctaaat aacagtctga atccggcaat ctcagaggac  1260
aacgatttca ataccactac aaacacattt atcgatagta ttatggccga agcaaatgcg  1320
gacaacggtc gttttatgat ggaactcggt aagtacctgc gcgtcggttt cttcccggat  1380
gttaaaacca ccatcaactt atcgggacca gaagcgtatg ctgcggccta ccaggatctg  1440
ctgatgttta aagaaggaag catgaatata catctaattg aagcagacct gcgtaacttc  1500
gagatatcta aaaccaacat ctcccaaagc accgaacagg aaatggcctc actgtggagc  1560
tttgacgatg cgcgcgcaaa agcccagttt gaagaatata aacgaaatta ctttgaaggt  1620
agcttg                                                             1626

<210>   62
<211>   228
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   62
Leu Ser Glu Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu Asp 
1               5                   10                  15      

Lys Asn Tyr Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu Glu 
            20                  25                  30          

Ala Gly Ser Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly Asn 
        35                  40                  45              

Asp Ile Ser Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro Lys 
    50                  55                  60                  

Asn Ser Ile Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser Tyr 
65                  70                  75                  80  

Phe Leu Ser Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr Arg 
                85                  90                  95      

Ile Pro Glu Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe Ile 
            100                 105                 110         

Gly Ala Gly Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu Ser 
        115                 120                 125             

Val Asp Ser Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile Lys 
    130                 135                 140                 

Leu Asp Ile Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala Asn 
145                 150                 155                 160 

Met Phe Ser Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu 
                165                 170                 175     

Leu Leu Ser Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val Asn 
            180                 185                 190         

Lys Asn Ser Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile Asn 
        195                 200                 205             

Ser Glu Gly Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile Asn 
    210                 215                 220                 

Lys Glu Glu Ala 
225             

<210>   63
<211>   735
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   63
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg cctgtccgaa  60
gacaatggag tggacttcaa caaaaatacc gctctagaca aaaactatct gctgaacaat  120
aaaatcccga gcaacaacgt ggaagaagca ggctcgaaaa attacgttca ttatataatt  180
caattacagg gcaacgatat tagctacgaa gcgacgtgca acctgttttc taaaaatcca  240
aaaaacagta tcatcattca aaggaatatg aacgagtcgg cgaaatcata ctttctgagt  300
gatgacggcg aaagcatcct ggaactgaat aaatatcgaa ttcctgaacg tctgaaaaac  360
aaggaaaaag tgaaagtgac attcatcggt gcgggtaaag atgaattcaa cacttcagaa  420
tttgcccgcc tgtcggtgga tagcctttca aatgagatta gcagcttttt agacacaatt  480
aaactggata ttagcccgaa aaacgtggaa gtgaacctgt tgggcgcgaa tatgttcagt  540
tatgatttta acgtcgaaga aacctaccca ggaaagctac tcctgtcgat catggacaaa  600
atcacctcaa ccctgcctga cgtgaataaa aactccatca ccattggcgc gaatcagtat  660
gaggtgcgta tcaacagtga gggccgcaaa gaactgctag cacacagcgg taaatggatt  720
aataaagaag aagcc                                                   735

<210>   64
<211>   224
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   64
Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys 
1               5                   10                  15      

Glu Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg 
            20                  25                  30          

Gly Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asn Lys Ile Ser Tyr 
        35                  40                  45              

Glu Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu 
    50                  55                  60                  

Phe Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro 
65                  70                  75                  80  

Gly Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile 
                85                  90                  95      

Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Ala Gly Lys 
            100                 105                 110         

Asp Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu 
        115                 120                 125             

Ser Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser 
    130                 135                 140                 

Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr 
145                 150                 155                 160 

Ser Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val 
                165                 170                 175     

Lys Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile 
            180                 185                 190         

Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg 
        195                 200                 205             

Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser 
    210                 215                 220                 

<210>   65
<211>   672
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   65
ggtgaagatg acaaccttga tttctctcaa aatattgtgg tcgacaagga gtatctgctg  60
gaaaaaattt ccagcttagc gcgttcgagc gagcgcggct atattcacta catcgttcaa  120
ctgcagggca acaaaatcag ttatgaagcg gcgtgcaacc tgtttgcgaa gaccccgtat  180
gacagtgtgc tatttcaaaa aaacattgaa gatagcgaga tcgcgtacta ttacaatcct  240
ggcgatggtg aaattcagga aattgacaag tataaaatcc cgtcgattat ctctgaccgt  300
ccaaagatca aactgacgtt tatcggtgcg ggtaaagatg aattcaacac cgatattttt  360
gcgggttttg acgtggatag cctgtcaacg gaaattgaag cggcgattga tttagcaaaa  420
gaggacatct ccccgaagag cattgaaatt aatctgctgg gcgcgaacat gttttcatac  480
agcataaacg tggaggagac ctatcctggt aaactgctgt tgaaagtcaa agataaaatt  540
agcgaattaa tgccgtctat tagccaagac tccatcattg tgtcggcgaa tcagtacgaa  600
gttcgcatta acagtgaagg ccgtcgcgag ctgctagatc attctggtga atggattaat  660
aaagaagaaa gt                                                      672

<210>   66
<211>   624
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   66
catatgcgtt actacttcga taccgataca gccatcgctt ttaacggtta taaaaccatc  60
gacggtaaac acttttactt tgatagcgat tgtgtggtaa aaattggtgt attctcgaca  120
agcaatggct ttgaatattt tgcgccggca aacacctata ataacaacat tgaaggtcaa  180
gccattgtct accagagtaa attcctgacc ctaaatggta aaaaatatta cttcgacaac  240
aacagcaaag cggttacagg ctggcagacc atcgattcga aaaaatatta ctttaatacc  300
aacaccgcag aagcggccac cggttggcaa accatcgatg gtaaaaaata ctactttaac  360
accaacaccg cagaagcggc caccggctgg cagaccatcg acggtaaaaa atattacttc  420
aataccaaca ccgcaattgc cagcaccggt tacacgatca tcaacggtaa acatttttat  480
tttaataccg atggtatcat gcaaattggc gtattcaaag gcccaaacgg ctttgaatat  540
tttgcgcctg caaatacaga tgccaacaac attgagggtc aggcaatttt gtaccaaaac  600
gaattcctga ccctaaatct cgag                                         624

<210>   67
<211>   2601
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   67
catatggacc caattgaatt taacctggtg accggttggc aaaccataaa cggtaaaaaa  60
tattattttg acattaatac cggcgcggca ctgatcagtt acaaaatcat caacggtaaa  120
cacttttatt tcaataacga tggtgtaatg caactaggcg tgtttaaagg ccctgatggt  180
tttgaatact tcgcgccggc taatacccag aacaataaca ttgaaggtca agccattgtc  240
tatcagtcga aattcttaac cctaaacgga aaaaaatatt actttgacaa tgacagcaaa  300
gcggtaaccg gctggcgcat catcaacaac gagaaatatt actttaatcc aaacaatgca  360
atcgccgcgg taggcctaca agtgatcgac aacaataagt attacttcaa ccctgacacc  420
gcaataataa gcaaaggttg gcaaaccgtt aatggtagtc gttactactt cgataccgat  480
acagccatcg cttttaacgg ttataaaacc atcgacggta aacactttta ctttgatagc  540
gattgtgtgg taaaaattgg tgtattctcg acaagcaatg gctttgaata ttttgcgccg  600
gcaaacacct ataataacaa cattgaaggt caagccattg tctaccagag taaattcctg  660
accctaaatg gtaaaaaata ttacttcgac aacaacagca aagcggttac aggctggcag  720
accatcgatt cgaaaaaata ttactttaat accaacaccg cagaagcggc caccggttgg  780
caaaccatcg atggtaaaaa atactacttt aacaccaaca ccgcagaagc ggccaccggc  840
tggcagacca tcgacggtaa aaaatattac ttcaatacca acaccgcaat tgccagcacc  900
ggttacacga tcatcaacgg taaacatttt tattttaata ccgatggtat catgcaaatt  960
ggcgtattca aaggcccaaa cggctttgaa tattttgcgc ctgcaaatac agatgccaac  1020
aacattgagg gtcaggcaat tttgtaccaa aacgaattcc tgaccctaaa tggtaaaaaa  1080
tactacttcg gtagtgacag caaagcggtc accggttggc gcatcatcaa caacaagaaa  1140
tattacttta atccgaacaa tgccatcgca gcgatccatc tctgcaccat taacaatgac  1200
aagtattact ttagctacga cggcatcctg cagaacggct atatcaccat cgaacgtaat  1260
aacttctact tcgatgccaa taacgaatcc aaaatggtga cgggcgtgtt taaaggccca  1320
aatggttttg agtatttcgc gccggcaaac acccacaata acaacattga aggtcaagcc  1380
attgtttacc aaaacaaatt cctgacccta aatggaaaaa aatattactt tgataacgac  1440
agcaaagcgg tcaccggctg gcagacaatc gacggtaaaa aatattactt taatcttaac  1500
accgcagaag cggccaccgg ctggcaaacc atcgatggta aaaaatatta cttcaacttg  1560
aacaccgcag aagcggccac cggctggcag accatcgatg gtaaaaaata ctactttaat  1620
accaacacct tcattgctag caccggttat acttcgatca acggtaaaca tttttacttt  1680
aataccgacg gtatcatgca aattggcgta ttcaaaggtc ctaacggctt tgaatacttt  1740
gcgccagcaa atacccacaa caataacatt gaaggtcagg ccattctgta ccaaaacaaa  1800
ttcctgaccc taaatggtaa aaaatattac ttcggtagtg acagcaaagc ggttacaggc  1860
ctaaggacca tcgatggtaa aaaatattac tttaacacca acaccgcagt cgcggttacc  1920
ggctggcaga ccatcaatgg taaaaaatac tactttaaca ccaacacctc tattgccagc  1980
accggttaca cgatcatctc gggtaaacat ttctatttta ataccgatgg tatcatgcaa  2040
attggcgtat ttaaaggtcc ggacggcttc gaatactttg cgcctgcaaa cacggatgcc  2100
aacaatattg agggtcaggc aattagatat caaaaccgct tcctctacct gcatgacaat  2160
atttattact ttggtaacaa tagcaaagcg gccaccggtt gggtgaccat cgatggtaac  2220
cgttattact tcgagccaaa tacggcaatg ggtgctaacg gttataaaac catcgacaat  2280
aaaaacttct actttcgcaa tggtctgccg caaattggcg tatttaaagg atctaacggc  2340
ttcgaatact ttgcgcctgc caatacagat gcaaacaaca ttgaaggtca ggccattaga  2400
taccaaaatc gtttcctcca tttacttggc aaaatttatt actttggtaa caatagcaaa  2460
gcggtcaccg gttggcaaac catcaacggt aaagtgtatt actttatgcc agataccgca  2520
atggccgcgg caggtggctt gttcgagatc gacggtgtta tttacttctt cggtgtcgat  2580
ggcgtgaaag ctccgctcga g                                            2601

<210>   68
<211>   1548
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Mutated sequence

<400>   68
attaccggct tcgtaaccgt gggagacgat aaatactact ttaacccgat caatggtggt  60
gccgcaagca tcggcgagac gattatcgat gacaaaaact attatttcaa ccagagcggc  120
gtactgcaaa cgggtgtgtt ttcgacggag gacggcttca aatactttgc tccggccaat  180
actctggatg aaaacctcga aggcgaagcg atcgatttta ccggtaaact gatcatcgac  240
gaaaacatct attattttga cgataattac cgtggcgcag tggaatggaa agaactggat  300
ggtgagatgc actatttctc accggaaacg ggtaaagcct ttaaaggtct caaccagatt  360
ggtgactaca aatactattt caattccgat ggcgtcatgc agaaaggctt tgttagtatt  420
aacgataata aacactattt tgacgattct ggtgtcatga aagtgggtta caccgaaatt  480
gatggaaagc atttctactt cgcagaaaac ggcgaaatgc agattggtgt gtttaacacg  540
gaagacggct ttaaatactt cgcccaccat aatgaagatt taggcaacga agagggtgaa  600
gaaataagct attccggtat tctgaatttc aacaataaaa tctactactt tgatgacagc  660
tttactgcag tggttggctg gaaagatctg gaggacggta gcaagtatta tttcgatgaa  720
gatacggcgg aagcgtacat tggtctaagc ctgattaacg acggtcaata ttactttaat  780
gatgatggca tcatgcaggt cggttttgta accattaacg acaaagtatt ctacttcagc  840
gactctggca tcattgaatc cggcgtgcag aacattgatg acaattattt ctatattgat  900
gacaacggta ttgttcagat cggtgtgttt gataccagcg atggctacaa atatttcgcg  960
ccggccaata ccgtgaacga caatatctac ggccaagcgg tcgaatatag tggtctggtt  1020
cgcgtcggtg aagatgtgta ctattttggt gagacgtata ctatcgagac cggctggatt  1080
tacgatatgg aaaacgaatc ggacaaatat tacttcaatc cggaaaccaa aaaagcgtgc  1140
aaaggtatca acctgatcga tgatattaaa tattattttg acgagaaggg aattatgcgt  1200
acaggtttga ttagcttcga aaataacaat tactacttta acgagaatgg tgaaatgcag  1260
tttggttata ttaacattga agataagatg ttctactttg gtgaagatgg tgtaatgcaa  1320
atcggcgtgt tcaatacgcc ggacggcttt aaatactttg cgcatcagaa caccctagat  1380
gagaattttg agggcgagag cattaactat accggttggc tggatttaga cgaaaagcgc  1440
tactatttca cggatgaata tatcgcggcg accggtagcg ttatcatcga tggtgaggag  1500
tactattttg accctgatac ggcacaactg gtaatcagcg aactcgag               1548

<210>   69
<211>   636
<212>   DNA
<213>   Mutated sequence

<400>   69
gttcagatcg gtgtgtttga taccagcgat ggctacaaat atttcgcgcc ggccaatacc  60
gtgaacgaca atatctacgg ccaagcggtc gaatatagtg gtctggttcg cgtcggtgaa  120
gatgtgtact attttggtga gacgtatact atcgagaccg gctggattta cgatatggaa  180
aacgaatcgg acaaatatta cttcaatccg gaaaccaaaa aagcgtgcaa aggtatcaac  240
ctgatcgatg atattaaata ttattttgac gagaagggaa ttatgcgtac aggtttgatt  300
agcttcgaaa ataacaatta ctactttaac gagaatggtg aaatgcagtt tggttatatt  360
aacattgaag ataagatgtt ctactttggt gaagatggtg taatgcaaat cggcgtgttc  420
aatacgccgg acggctttaa atactttgcg catcagaaca ccctagatga gaattttgag  480
ggcgagagca ttaactatac cggttggctg gatttagacg aaaagcgcta ctatttcacg  540
gatgaatata tcgcggcgac cggtagcgtt atcatcgatg gtgaggagta ctattttgac  600
cctgatacgg cacaactggt aatcagcgaa ctcgag                            636

<210>   70
<211>   624
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   70
catatgcgtt actacttcga taccgataca gccatcgctt ttaacggtta taaaaccatc  60
gacggtaaac acttttactt tgatagcgat tgtgtggtaa aaattggtgt attctcgaca  120
agcaatggct ttgaatattt tgcgccggca aacacctata ataacaacat tgaaggtcaa  180
gccattgtct accagagtaa attcctgacc ctaaatggta aaaaatatta cttcgacaac  240
aacagcaaag cggttacagg ctggcagacc atcgattcga aaaaatatta ctttaatacc  300
aacaccgcag aagcggccac cggttggcaa accatcgatg gtaaaaaata ctactttaac  360
accaacaccg cagaagcggc caccggctgg cagaccatcg acggtaaaaa atattacttc  420
aataccaaca ccgcaattgc cagcaccggt tacacgatca tcaacggtaa acatttttat  480
tttaataccg atggtatcat gcaaattggc gtattcaaag gcccaaacgg ctttgaatat  540
tttgcgcctg caaatacaga tgccaacaac attgagggtc aggcaatttt gtaccaaaac  600
gaattcctga ccctaaatct cgag                                         624

<210>   71
<211>   207
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   71
Met Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr 
1               5                   10                  15      

Lys Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val 
            20                  25                  30          

Lys Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro 
        35                  40                  45              

Ala Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln 
    50                  55                  60                  

Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn 
65                  70                  75                  80  

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr 
                85                  90                  95      

Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp 
            100                 105                 110         

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly 
        115                 120                 125             

Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala 
    130                 135                 140                 

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe 
145                 150                 155                 160 

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly 
                165                 170                 175     

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
            180                 185                 190         

Gln Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Leu Glu 
        195                 200                 205         

<210>   72
<211>   2601
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   72
catatggacc caattgaatt taacctggtg accggttggc aaaccataaa cggtaaaaaa  60
tattattttg acattaatac cggcgcggca ctgatcagtt acaaaatcat caacggtaaa  120
cacttttatt tcaataacga tggtgtaatg caactaggcg tgtttaaagg ccctgatggt  180
tttgaatact tcgcgccggc taatacccag aacaataaca ttgaaggtca agccattgtc  240
tatcagtcga aattcttaac cctaaacgga aaaaaatatt actttgacaa tgacagcaaa  300
gcggtaaccg gctggcgcat catcaacaac gagaaatatt actttaatcc aaacaatgca  360
atcgccgcgg taggcctaca agtgatcgac aacaataagt attacttcaa ccctgacacc  420
gcaataataa gcaaaggttg gcaaaccgtt aatggtagtc gttactactt cgataccgat  480
acagccatcg cttttaacgg ttataaaacc atcgacggta aacactttta ctttgatagc  540
gattgtgtgg taaaaattgg tgtattctcg acaagcaatg gctttgaata ttttgcgccg  600
gcaaacacct ataataacaa cattgaaggt caagccattg tctaccagag taaattcctg  660
accctaaatg gtaaaaaata ttacttcgac aacaacagca aagcggttac aggctggcag  720
accatcgatt cgaaaaaata ttactttaat accaacaccg cagaagcggc caccggttgg  780
caaaccatcg atggtaaaaa atactacttt aacaccaaca ccgcagaagc ggccaccggc  840
tggcagacca tcgacggtaa aaaatattac ttcaatacca acaccgcaat tgccagcacc  900
ggttacacga tcatcaacgg taaacatttt tattttaata ccgatggtat catgcaaatt  960
ggcgtattca aaggcccaaa cggctttgaa tattttgcgc ctgcaaatac agatgccaac  1020
aacattgagg gtcaggcaat tttgtaccaa aacgaattcc tgaccctaaa tggtaaaaaa  1080
tactacttcg gtagtgacag caaagcggtc accggttggc gcatcatcaa caacaagaaa  1140
tattacttta atccgaacaa tgccatcgca gcgatccatc tctgcaccat taacaatgac  1200
aagtattact ttagctacga cggcatcctg cagaacggct atatcaccat cgaacgtaat  1260
aacttctact tcgatgccaa taacgaatcc aaaatggtga cgggcgtgtt taaaggccca  1320
aatggttttg agtatttcgc gccggcaaac acccacaata acaacattga aggtcaagcc  1380
attgtttacc aaaacaaatt cctgacccta aatggaaaaa aatattactt tgataacgac  1440
agcaaagcgg tcaccggctg gcagacaatc gacggtaaaa aatattactt taatcttaac  1500
accgcagaag cggccaccgg ctggcaaacc atcgatggta aaaaatatta cttcaacttg  1560
aacaccgcag aagcggccac cggctggcag accatcgatg gtaaaaaata ctactttaat  1620
accaacacct tcattgctag caccggttat acttcgatca acggtaaaca tttttacttt  1680
aataccgacg gtatcatgca aattggcgta ttcaaaggtc ctaacggctt tgaatacttt  1740
gcgccagcaa atacccacaa caataacatt gaaggtcagg ccattctgta ccaaaacaaa  1800
ttcctgaccc taaatggtaa aaaatattac ttcggtagtg acagcaaagc ggttacaggc  1860
ctaaggacca tcgatggtaa aaaatattac tttaacacca acaccgcagt cgcggttacc  1920
ggctggcaga ccatcaatgg taaaaaatac tactttaaca ccaacacctc tattgccagc  1980
accggttaca cgatcatctc gggtaaacat ttctatttta ataccgatgg tatcatgcaa  2040
attggcgtat ttaaaggtcc ggacggcttc gaatactttg cgcctgcaaa cacggatgcc  2100
aacaatattg agggtcaggc aattagatat caaaaccgct tcctctacct gcatgacaat  2160
atttattact ttggtaacaa tagcaaagcg gccaccggtt gggtgaccat cgatggtaac  2220
cgttattact tcgagccaaa tacggcaatg ggtgctaacg gttataaaac catcgacaat  2280
aaaaacttct actttcgcaa tggtctgccg caaattggcg tatttaaagg atctaacggc  2340
ttcgaatact ttgcgcctgc caatacagat gcaaacaaca ttgaaggtca ggccattaga  2400
taccaaaatc gtttcctcca tttacttggc aaaatttatt actttggtaa caatagcaaa  2460
gcggtcaccg gttggcaaac catcaacggt aaagtgtatt actttatgcc agataccgca  2520
atggccgcgg caggtggctt gttcgagatc gacggtgtta tttacttctt cggtgtcgat  2580
ggcgtgaaag ctccgctcga g                                            2601

<210>   73
<211>   866
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   73
Met Asp Pro Ile Glu Phe Asn Leu Val Thr Gly Trp Gln Thr Ile Asn 
1               5                   10                  15      

Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly Ala Ala Leu Ile Ser 
            20                  25                  30          

Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Asn Asp Gly Val 
        35                  40                  45              

Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala 
    50                  55                  60                  

Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr 
65                  70                  75                  80  

Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn 
                85                  90                  95      

Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys Tyr 
            100                 105                 110         

Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val Ile 
        115                 120                 125             

Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser Lys 
    130                 135                 140                 

Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp Thr 
145                 150                 155                 160 

Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe Tyr 
                165                 170                 175     

Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr Ser Asn 
            180                 185                 190         

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile Glu 
        195                 200                 205             

Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys 
    210                 215                 220                 

Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr 
225                 230                 235                 240 

Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala 
                245                 250                 255     

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn 
            260                 265                 270         

Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
        275                 280                 285             

Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile Ile 
    290                 295                 300                 

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly 
305                 310                 315                 320 

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr 
                325                 330                 335     

Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu Phe 
            340                 345                 350         

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala 
        355                 360                 365             

Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn Pro 
    370                 375                 380                 

Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp Lys 
385                 390                 395                 400 

Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr Ile 
                405                 410                 415     

Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met Val 
            420                 425                 430         

Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
        435                 440                 445             

Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn 
    450                 455                 460                 

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser 
465                 470                 475                 480 

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe 
                485                 490                 495     

Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
            500                 505                 510         

Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp 
        515                 520                 525             

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile 
    530                 535                 540                 

Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
545                 550                 555                 560 

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
                565                 570                 575     

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln 
            580                 585                 590         

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
        595                 600                 605             

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
    610                 615                 620                 

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
625                 630                 635                 640 

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
                645                 650                 655     

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
            660                 665                 670         

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
        675                 680                 685             

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
    690                 695                 700                 

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
705                 710                 715                 720 

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
                725                 730                 735     

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
            740                 745                 750         

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
        755                 760                 765             

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
    770                 775                 780                 

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
785                 790                 795                 800 

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
                805                 810                 815     

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
            820                 825                 830         

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
        835                 840                 845             

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
    850                 855                 860                 

Leu Glu 
865     

<210>   74
<211>   1383
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   74
catatgatcc tgcagaacgg ctatatcacc atcgaacgta ataacttcta cttcgatgcc  60
aataacgaat ccaaaatggt gacgggcgtg tttaaaggcc caaatggttt tgagtatttc  120
gcgccggcaa acacccacaa taacaacatt gaaggtcaag ccattgttta ccaaaacaaa  180
ttcctgaccc taaatggaaa aaaatattac tttgataacg acagcaaagc ggtcaccggc  240
tggcagacaa tcgacggtaa aaaatattac tttaatctta acaccgcaga agcggccacc  300
ggctggcaaa ccatcgatgg taaaaaatat tacttcaact tgaacaccgc agaagcggcc  360
accggctggc agaccatcga tggtaaaaaa tactacttta ataccaacac cttcattgct  420
agcaccggtt atacttcgat caacggtaaa catttttact ttaataccga cggtatcatg  480
caaattggcg tattcaaagg tcctaacggc tttgaatact ttgcgccagc aaatacccac  540
aacaataaca ttgaaggtca ggccattctg taccaaaaca aattcctgac cctaaatggt  600
aaaaaatatt acttcggtag tgacagcaaa gcggttacag gcctaaggac catcgatggt  660
aaaaaatatt actttaacac caacaccgca gtcgcggtta ccggctggca gaccatcaat  720
ggtaaaaaat actactttaa caccaacacc tctattgcca gcaccggtta cacgatcatc  780
tcgggtaaac atttctattt taataccgat ggtatcatgc aaattggcgt atttaaaggt  840
ccggacggct tcgaatactt tgcgcctgca aacacggatg ccaacaatat tgagggtcag  900
gcaattagat atcaaaaccg cttcctctac ctgcatgaca atatttatta ctttggtaac  960
aatagcaaag cggccaccgg ttgggtgacc atcgatggta accgttatta cttcgagcca  1020
aatacggcaa tgggtgctaa cggttataaa accatcgaca ataaaaactt ctactttcgc  1080
aatggtctgc cgcaaattgg cgtatttaaa ggatctaacg gcttcgaata ctttgcgcct  1140
gccaatacag atgcaaacaa cattgaaggt caggccatta gataccaaaa tcgtttcctc  1200
catttacttg gcaaaattta ttactttggt aacaatagca aagcggtcac cggttggcaa  1260
accatcaacg gtaaagtgta ttactttatg ccagataccg caatggccgc ggcaggtggc  1320
ttgttcgaga tcgacggtgt tatttacttc ttcggtgtcg atggcgtgaa agctccgctc  1380
gag                                                                1383

<210>   75
<211>   460
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   75
Met Ile Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr 
1               5                   10                  15      

Phe Asp Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly 
            20                  25                  30          

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn 
        35                  40                  45              

Ile Glu Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn 
    50                  55                  60                  

Gly Lys Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp 
65                  70                  75                  80  

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu 
                85                  90                  95      

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
            100                 105                 110         

Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys 
        115                 120                 125             

Lys Tyr Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr 
    130                 135                 140                 

Ser Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
145                 150                 155                 160 

Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
                165                 170                 175     

Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn 
            180                 185                 190         

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser 
        195                 200                 205             

Lys Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe 
    210                 215                 220                 

Asn Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly 
225                 230                 235                 240 

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr 
                245                 250                 255     

Thr Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met 
            260                 265                 270         

Gln Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro 
        275                 280                 285             

Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln 
    290                 295                 300                 

Asn Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn 
305                 310                 315                 320 

Ser Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr 
                325                 330                 335     

Phe Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp 
            340                 345                 350         

Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe 
        355                 360                 365             

Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala 
    370                 375                 380                 

Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His 
385                 390                 395                 400 

Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr 
                405                 410                 415     

Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr 
            420                 425                 430         

Ala Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr 
        435                 440                 445             

Phe Phe Gly Val Asp Gly Val Lys Ala Pro Leu Glu 
    450                 455                 460 

<210>   76
<211>   889
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   76
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Ser Leu Phe Tyr Phe Asp Pro Ile Glu Phe Asn Leu Val Thr Gly 
            20                  25                  30          

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Ile Asn Thr Gly 
        35                  40                  45              

Ala Ala Leu Ile Ser Tyr Lys Ile Ile Asn Gly Lys His Phe Tyr Phe 
    50                  55                  60                  

Asn Asn Asp Gly Val Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly 
65                  70                  75                  80  

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly 
                85                  90                  95      

Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys 
            100                 105                 110         

Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile 
        115                 120                 125             

Asn Asn Glu Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val 
    130                 135                 140                 

Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr 
145                 150                 155                 160 

Ala Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr 
                165                 170                 175     

Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp 
            180                 185                 190         

Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val 
        195                 200                 205             

Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr 
    210                 215                 220                 

Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu 
225                 230                 235                 240 

Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val 
                245                 250                 255     

Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn 
            260                 265                 270         

Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
        275                 280                 285             

Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile 
    290                 295                 300                 

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr 
305                 310                 315                 320 

Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly 
                325                 330                 335     

Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe 
            340                 345                 350         

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu 
        355                 360                 365             

Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly 
    370                 375                 380                 

Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys 
385                 390                 395                 400 

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr 
                405                 410                 415     

Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn 
            420                 425                 430         

Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn 
        435                 440                 445             

Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu 
    450                 455                 460                 

Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala 
465                 470                 475                 480 

Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr 
                485                 490                 495     

Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly 
            500                 505                 510         

Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp 
        515                 520                 525             

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu 
    530                 535                 540                 

Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
545                 550                 555                 560 

Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys 
                565                 570                 575     

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys 
            580                 585                 590         

Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn 
        595                 600                 605             

Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu 
    610                 615                 620                 

Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly 
625                 630                 635                 640 

Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala 
                645                 650                 655     

Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe 
            660                 665                 670         

Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly 
        675                 680                 685             

Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe 
    690                 695                 700                 

Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala 
705                 710                 715                 720 

Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr 
                725                 730                 735     

Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr 
            740                 745                 750         

Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr 
        755                 760                 765             

Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr 
    770                 775                 780                 

Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly 
785                 790                 795                 800 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
                805                 810                 815     

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile 
            820                 825                 830         

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile 
        835                 840                 845             

Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala 
    850                 855                 860                 

Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp 
865                 870                 875                 880 

Gly Val Lys Ala Pro Gly Ile Tyr Gly 
                885                 

<210>   77
<211>   2667
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   77
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg ctcattattc  60
tattttgatc ctatagaatt taacttagta actggatggc aaactatcaa tggtaaaaaa  120
tattattttg atataaatac tggagcagct ttaattagtt ataaaattat taatggtaaa  180
cacttttatt ttaataatga tggtgtgatg cagttgggag tatttaaagg acctgatgga  240
tttgaatatt ttgcacctgc caatactcaa aataataaca tagaaggtca ggctatagtt  300
tatcaaagta aattcttaac tttgaatggc aaaaaatatt attttgataa tgactcaaaa  360
gcagtcactg gatggagaat tattaacaat gagaaatatt actttaatcc taataatgct  420
attgctgcag tcggattgca agtaattgac aataataagt attatttcaa tcctgacact  480
gctatcatct caaaaggttg gcagactgtt aatggtagta gatactactt tgatactgat  540
accgctattg cctttaatgg ttataaaact attgatggta aacactttta ttttgatagt  600
gattgtgtag tgaaaatagg tgtgtttagt acctctaatg gatttgaata ttttgcacct  660
gctaatactt ataataataa catagaaggt caggctatag tttatcaaag taaattctta  720
actttgaatg gtaaaaaata ttactttgat aataactcaa aagcagttac cggatggcaa  780
actattgata gtaaaaaata ttactttaat actaacactg ctgaagcagc tactggatgg  840
caaactattg atggtaaaaa atattacttt aatactaaca ctgctgaagc agctactgga  900
tggcaaacta ttgatggtaa aaaatattac tttaatacta acactgctat agcttcaact  960
ggttatacaa ttattaatgg taaacatttt tattttaata ctgatggtat tatgcagata  1020
ggagtgttta aaggacctaa tggatttgaa tattttgcac ctgctaatac ggatgctaac  1080
aacatagaag gtcaagctat actttaccaa aatgaattct taactttgaa tggtaaaaaa  1140
tattactttg gtagtgactc aaaagcagtt actggatgga gaattattaa caataagaaa  1200
tattacttta atcctaataa tgctattgct gcaattcatc tatgcactat aaataatgac  1260
aagtattact ttagttatga tggaattctt caaaatggat atattactat tgaaagaaat  1320
aatttctatt ttgatgctaa taatgaatct aaaatggtaa caggagtatt taaaggacct  1380
aatggatttg agtattttgc acctgctaat actcacaata ataacataga aggtcaggct  1440
atagtttacc agaacaaatt cttaactttg aatggcaaaa aatattattt tgataatgac  1500
tcaaaagcag ttactggatg gcaaaccatt gatggtaaaa aatattactt taatcttaac  1560
actgctgaag cagctactgg atggcaaact attgatggta aaaaatatta ctttaatctt  1620
aacactgctg aagcagctac tggatggcaa actattgatg gtaaaaaata ttactttaat  1680
actaacactt tcatagcctc aactggttat acaagtatta atggtaaaca tttttatttt  1740
aatactgatg gtattatgca gataggagtg tttaaaggac ctaatggatt tgaatacttt  1800
gcacctgcta atactcataa taataacata gaaggtcaag ctatacttta ccaaaataaa  1860
ttcttaactt tgaatggtaa aaaatattac tttggtagtg actcaaaagc agttaccgga  1920
ttgcgaacta ttgatggtaa aaaatattac tttaatacta acactgctgt tgcagttact  1980
ggatggcaaa ctattaatgg taaaaaatac tactttaata ctaacacttc tatagcttca  2040
actggttata caattattag tggtaaacat ttttatttta atactgatgg tattatgcag  2100
ataggagtgt ttaaaggacc tgatggattt gaatactttg cacctgctaa tacagatgct  2160
aacaatatag aaggtcaagc tatacgttat caaaatagat tcctatattt acatgacaat  2220
atatattatt ttggtaataa ttcaaaagca gctactggtt gggtaactat tgatggtaat  2280
agatattact tcgagcctaa tacagctatg ggtgcgaatg gttataaaac tattgataat  2340
aaaaattttt actttagaaa tggtttacct cagataggag tgtttaaagg gtctaatgga  2400
tttgaatact ttgcacctgc taatacggat gctaacaata tagaaggtca agctatacgt  2460
tatcaaaata gattcctaca tttacttgga aaaatatatt actttggtaa taattcaaaa  2520
gcagttactg gatggcaaac tattaatggt aaagtatatt actttatgcc tgatactgct  2580
atggctgcag ctggtggact tttcgagatt gatggtgtta tatatttctt tggtgttgat  2640
ggagtaaaag cccctgggat atatggc                                      2667

<210>   78
<211>   833
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   78
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Met Gln Leu Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe 
            20                  25                  30          

Ala Pro Ala Asn Thr Gln Asn Asn Asn Ile Glu Gly Gln Ala Ile Val 
        35                  40                  45              

Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp 
    50                  55                  60                  

Asn Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Glu Lys 
65                  70                  75                  80  

Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Val Gly Leu Gln Val 
                85                  90                  95      

Ile Asp Asn Asn Lys Tyr Tyr Phe Asn Pro Asp Thr Ala Ile Ile Ser 
            100                 105                 110         

Lys Gly Trp Gln Thr Val Asn Gly Ser Arg Tyr Tyr Phe Asp Thr Asp 
        115                 120                 125             

Thr Ala Ile Ala Phe Asn Gly Tyr Lys Thr Ile Asp Gly Lys His Phe 
    130                 135                 140                 

Tyr Phe Asp Ser Asp Cys Val Val Lys Ile Gly Val Phe Ser Thr Ser 
145                 150                 155                 160 

Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Tyr Asn Asn Asn Ile 
                165                 170                 175     

Glu Gly Gln Ala Ile Val Tyr Gln Ser Lys Phe Leu Thr Leu Asn Gly 
            180                 185                 190         

Lys Lys Tyr Tyr Phe Asp Asn Asn Ser Lys Ala Val Thr Gly Trp Gln 
        195                 200                 205             

Thr Ile Asp Ser Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala 
    210                 215                 220                 

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr 
225                 230                 235                 240 

Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys 
                245                 250                 255     

Tyr Tyr Phe Asn Thr Asn Thr Ala Ile Ala Ser Thr Gly Tyr Thr Ile 
            260                 265                 270         

Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile 
        275                 280                 285             

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
    290                 295                 300                 

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Glu 
305                 310                 315                 320 

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys 
                325                 330                 335     

Ala Val Thr Gly Trp Arg Ile Ile Asn Asn Lys Lys Tyr Tyr Phe Asn 
            340                 345                 350         

Pro Asn Asn Ala Ile Ala Ala Ile His Leu Cys Thr Ile Asn Asn Asp 
        355                 360                 365             

Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile Leu Gln Asn Gly Tyr Ile Thr 
    370                 375                 380                 

Ile Glu Arg Asn Asn Phe Tyr Phe Asp Ala Asn Asn Glu Ser Lys Met 
385                 390                 395                 400 

Val Thr Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro 
                405                 410                 415     

Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln 
            420                 425                 430         

Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asp 
        435                 440                 445             

Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr 
    450                 455                 460                 

Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp 
465                 470                 475                 480 

Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly 
                485                 490                 495     

Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Phe 
            500                 505                 510         

Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe 
        515                 520                 525             

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly 
    530                 535                 540                 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly 
545                 550                 555                 560 

Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys 
                565                 570                 575     

Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile 
            580                 585                 590         

Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr 
        595                 600                 605             

Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr 
    610                 615                 620                 

Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr 
625                 630                 635                 640 

Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp 
                645                 650                 655     

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu 
            660                 665                 670         

Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn 
        675                 680                 685             

Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr 
    690                 695                 700                 

Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala 
705                 710                 715                 720 

Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly 
                725                 730                 735     

Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe 
            740                 745                 750         

Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg 
        755                 760                 765             

Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly 
    770                 775                 780                 

Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val 
785                 790                 795                 800 

Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe 
                805                 810                 815     

Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala 
            820                 825                 830         

Pro 
    

<210>   79
<211>   2499
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   79
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg catgcagttg  60
ggagtattta aaggacctga tggatttgaa tattttgcac ctgccaatac tcaaaataat  120
aacatagaag gtcaggctat agtttatcaa agtaaattct taactttgaa tggcaaaaaa  180
tattattttg ataatgactc aaaagcagtc actggatgga gaattattaa caatgagaaa  240
tattacttta atcctaataa tgctattgct gcagtcggat tgcaagtaat tgacaataat  300
aagtattatt tcaatcctga cactgctatc atctcaaaag gttggcagac tgttaatggt  360
agtagatact actttgatac tgataccgct attgccttta atggttataa aactattgat  420
ggtaaacact tttattttga tagtgattgt gtagtgaaaa taggtgtgtt tagtacctct  480
aatggatttg aatattttgc acctgctaat acttataata ataacataga aggtcaggct  540
atagtttatc aaagtaaatt cttaactttg aatggtaaaa aatattactt tgataataac  600
tcaaaagcag ttaccggatg gcaaactatt gatagtaaaa aatattactt taatactaac  660
actgctgaag cagctactgg atggcaaact attgatggta aaaaatatta ctttaatact  720
aacactgctg aagcagctac tggatggcaa actattgatg gtaaaaaata ttactttaat  780
actaacactg ctatagcttc aactggttat acaattatta atggtaaaca tttttatttt  840
aatactgatg gtattatgca gataggagtg tttaaaggac ctaatggatt tgaatatttt  900
gcacctgcta atacggatgc taacaacata gaaggtcaag ctatacttta ccaaaatgaa  960
ttcttaactt tgaatggtaa aaaatattac tttggtagtg actcaaaagc agttactgga  1020
tggagaatta ttaacaataa gaaatattac tttaatccta ataatgctat tgctgcaatt  1080
catctatgca ctataaataa tgacaagtat tactttagtt atgatggaat tcttcaaaat  1140
ggatatatta ctattgaaag aaataatttc tattttgatg ctaataatga atctaaaatg  1200
gtaacaggag tatttaaagg acctaatgga tttgagtatt ttgcacctgc taatactcac  1260
aataataaca tagaaggtca ggctatagtt taccagaaca aattcttaac tttgaatggc  1320
aaaaaatatt attttgataa tgactcaaaa gcagttactg gatggcaaac cattgatggt  1380
aaaaaatatt actttaatct taacactgct gaagcagcta ctggatggca aactattgat  1440
ggtaaaaaat attactttaa tcttaacact gctgaagcag ctactggatg gcaaactatt  1500
gatggtaaaa aatattactt taatactaac actttcatag cctcaactgg ttatacaagt  1560
attaatggta aacattttta ttttaatact gatggtatta tgcagatagg agtgtttaaa  1620
ggacctaatg gatttgaata ctttgcacct gctaatactc ataataataa catagaaggt  1680
caagctatac tttaccaaaa taaattctta actttgaatg gtaaaaaata ttactttggt  1740
agtgactcaa aagcagttac cggattgcga actattgatg gtaaaaaata ttactttaat  1800
actaacactg ctgttgcagt tactggatgg caaactatta atggtaaaaa atactacttt  1860
aatactaaca cttctatagc ttcaactggt tatacaatta ttagtggtaa acatttttat  1920
tttaatactg atggtattat gcagatagga gtgtttaaag gacctgatgg atttgaatac  1980
tttgcacctg ctaatacaga tgctaacaat atagaaggtc aagctatacg ttatcaaaat  2040
agattcctat atttacatga caatatatat tattttggta ataattcaaa agcagctact  2100
ggttgggtaa ctattgatgg taatagatat tacttcgagc ctaatacagc tatgggtgcg  2160
aatggttata aaactattga taataaaaat ttttacttta gaaatggttt acctcagata  2220
ggagtgttta aagggtctaa tggatttgaa tactttgcac ctgctaatac ggatgctaac  2280
aatatagaag gtcaagctat acgttatcaa aatagattcc tacatttact tggaaaaata  2340
tattactttg gtaataattc aaaagcagtt actggatggc aaactattaa tggtaaagta  2400
tattacttta tgcctgatac tgctatggct gcagctggtg gacttttcga gattgatggt  2460
gttatatatt tctttggtgt tgatggagta aaagcccct                         2499

<210>   80
<211>   760
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   80
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Ala Val Gly Leu Gln Val Ile Asp Asn Asn Lys Tyr Tyr Phe Asn 
            20                  25                  30          

Pro Asp Thr Ala Ile Ile Ser Lys Gly Trp Gln Thr Val Asn Gly Ser 
        35                  40                  45              

Arg Tyr Tyr Phe Asp Thr Asp Thr Ala Ile Ala Phe Asn Gly Tyr Lys 
    50                  55                  60                  

Thr Ile Asp Gly Lys His Phe Tyr Phe Asp Ser Asp Cys Val Val Lys 
65                  70                  75                  80  

Ile Gly Val Phe Ser Thr Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala 
                85                  90                  95      

Asn Thr Tyr Asn Asn Asn Ile Glu Gly Gln Ala Ile Val Tyr Gln Ser 
            100                 105                 110         

Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Asp Asn Asn Ser 
        115                 120                 125             

Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Ser Lys Lys Tyr Tyr Phe 
    130                 135                 140                 

Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly 
145                 150                 155                 160 

Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Glu Ala Ala Thr Gly Trp 
                165                 170                 175     

Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Ile 
            180                 185                 190         

Ala Ser Thr Gly Tyr Thr Ile Ile Asn Gly Lys His Phe Tyr Phe Asn 
        195                 200                 205             

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
    210                 215                 220                 

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln 
225                 230                 235                 240 

Ala Ile Leu Tyr Gln Asn Glu Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
                245                 250                 255     

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Trp Arg Ile Ile Asn 
            260                 265                 270         

Asn Lys Lys Tyr Tyr Phe Asn Pro Asn Asn Ala Ile Ala Ala Ile His 
        275                 280                 285             

Leu Cys Thr Ile Asn Asn Asp Lys Tyr Tyr Phe Ser Tyr Asp Gly Ile 
    290                 295                 300                 

Leu Gln Asn Gly Tyr Ile Thr Ile Glu Arg Asn Asn Phe Tyr Phe Asp 
305                 310                 315                 320 

Ala Asn Asn Glu Ser Lys Met Val Thr Gly Val Phe Lys Gly Pro Asn 
                325                 330                 335     

Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu 
            340                 345                 350         

Gly Gln Ala Ile Val Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys 
        355                 360                 365             

Lys Tyr Tyr Phe Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr 
    370                 375                 380                 

Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala 
385                 390                 395                 400 

Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn 
                405                 410                 415     

Thr Ala Glu Ala Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr 
            420                 425                 430         

Tyr Phe Asn Thr Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile 
        435                 440                 445             

Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly 
    450                 455                 460                 

Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr 
465                 470                 475                 480 

His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe 
                485                 490                 495     

Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala 
            500                 505                 510         

Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr 
        515                 520                 525             

Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys 
    530                 535                 540                 

Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile 
545                 550                 555                 560 

Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile 
                565                 570                 575     

Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
            580                 585                 590         

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg 
        595                 600                 605             

Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys 
    610                 615                 620                 

Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu 
625                 630                 635                 640 

Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys 
                645                 650                 655     

Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly 
            660                 665                 670         

Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn 
        675                 680                 685             

Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu 
    690                 695                 700                 

Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp 
705                 710                 715                 720 

Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met 
                725                 730                 735     

Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe 
            740                 745                 750         

Gly Val Asp Gly Val Lys Ala Pro 
        755                 760 

<210>   81
<211>   2280
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   81
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg cgcagtcgga  60
ttgcaagtaa ttgacaataa taagtattat ttcaatcctg acactgctat catctcaaaa  120
ggttggcaga ctgttaatgg tagtagatac tactttgata ctgataccgc tattgccttt  180
aatggttata aaactattga tggtaaacac ttttattttg atagtgattg tgtagtgaaa  240
ataggtgtgt ttagtacctc taatggattt gaatattttg cacctgctaa tacttataat  300
aataacatag aaggtcaggc tatagtttat caaagtaaat tcttaacttt gaatggtaaa  360
aaatattact ttgataataa ctcaaaagca gttaccggat ggcaaactat tgatagtaaa  420
aaatattact ttaatactaa cactgctgaa gcagctactg gatggcaaac tattgatggt  480
aaaaaatatt actttaatac taacactgct gaagcagcta ctggatggca aactattgat  540
ggtaaaaaat attactttaa tactaacact gctatagctt caactggtta tacaattatt  600
aatggtaaac atttttattt taatactgat ggtattatgc agataggagt gtttaaagga  660
cctaatggat ttgaatattt tgcacctgct aatacggatg ctaacaacat agaaggtcaa  720
gctatacttt accaaaatga attcttaact ttgaatggta aaaaatatta ctttggtagt  780
gactcaaaag cagttactgg atggagaatt attaacaata agaaatatta ctttaatcct  840
aataatgcta ttgctgcaat tcatctatgc actataaata atgacaagta ttactttagt  900
tatgatggaa ttcttcaaaa tggatatatt actattgaaa gaaataattt ctattttgat  960
gctaataatg aatctaaaat ggtaacagga gtatttaaag gacctaatgg atttgagtat  1020
tttgcacctg ctaatactca caataataac atagaaggtc aggctatagt ttaccagaac  1080
aaattcttaa ctttgaatgg caaaaaatat tattttgata atgactcaaa agcagttact  1140
ggatggcaaa ccattgatgg taaaaaatat tactttaatc ttaacactgc tgaagcagct  1200
actggatggc aaactattga tggtaaaaaa tattacttta atcttaacac tgctgaagca  1260
gctactggat ggcaaactat tgatggtaaa aaatattact ttaatactaa cactttcata  1320
gcctcaactg gttatacaag tattaatggt aaacattttt attttaatac tgatggtatt  1380
atgcagatag gagtgtttaa aggacctaat ggatttgaat actttgcacc tgctaatact  1440
cataataata acatagaagg tcaagctata ctttaccaaa ataaattctt aactttgaat  1500
ggtaaaaaat attactttgg tagtgactca aaagcagtta ccggattgcg aactattgat  1560
ggtaaaaaat attactttaa tactaacact gctgttgcag ttactggatg gcaaactatt  1620
aatggtaaaa aatactactt taatactaac acttctatag cttcaactgg ttatacaatt  1680
attagtggta aacattttta ttttaatact gatggtatta tgcagatagg agtgtttaaa  1740
ggacctgatg gatttgaata ctttgcacct gctaatacag atgctaacaa tatagaaggt  1800
caagctatac gttatcaaaa tagattccta tatttacatg acaatatata ttattttggt  1860
aataattcaa aagcagctac tggttgggta actattgatg gtaatagata ttacttcgag  1920
cctaatacag ctatgggtgc gaatggttat aaaactattg ataataaaaa tttttacttt  1980
agaaatggtt tacctcagat aggagtgttt aaagggtcta atggatttga atactttgca  2040
cctgctaata cggatgctaa caatatagaa ggtcaagcta tacgttatca aaatagattc  2100
ctacatttac ttggaaaaat atattacttt ggtaataatt caaaagcagt tactggatgg  2160
caaactatta atggtaaagt atattacttt atgcctgata ctgctatggc tgcagctggt  2220
ggacttttcg agattgatgg tgttatatat ttctttggtg ttgatggagt aaaagcccct  2280

<210>   82
<211>   858
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   82
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg ctaccaaaat  60
aaattcttaa ctttgaatgg taaaaaatat tactttggta gtgactcaaa agcagttacc  120
ggattgcgaa ctattgatgg taaaaaatat tactttaata ctaacactgc tgttgcagtt  180
actggatggc aaactattaa tggtaaaaaa tactacttta atactaacac ttctatagct  240
tcaactggtt atacaattat tagtggtaaa catttttatt ttaatactga tggtattatg  300
cagataggag tgtttaaagg acctgatgga tttgaatact ttgcacctgc taatacagat  360
gctaacaata tagaaggtca agctatacgt tatcaaaata gattcctata tttacatgac  420
aatatatatt attttggtaa taattcaaaa gcagctactg gttgggtaac tattgatggt  480
aatagatatt acttcgagcc taatacagct atgggtgcga atggttataa aactattgat  540
aataaaaatt tttactttag aaatggttta cctcagatag gagtgtttaa agggtctaat  600
ggatttgaat actttgcacc tgctaatacg gatgctaaca atatagaagg tcaagctata  660
cgttatcaaa atagattcct acatttactt ggaaaaatat attactttgg taataattca  720
aaagcagtta ctggatggca aactattaat ggtaaagtat attactttat gcctgatact  780
gctatggctg cagctggtgg acttttcgag attgatggtg ttatatattt ctttggtgtt  840
gatggagtaa aagcccct                                                858

<210>   83
<211>   420
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   83
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe 
            20                  25                  30          

Asp Asn Asp Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asp Gly Lys 
        35                  40                  45              

Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala Ala Thr Gly Trp Gln 
    50                  55                  60                  

Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Leu Asn Thr Ala Glu Ala 
65                  70                  75                  80  

Ala Thr Gly Trp Gln Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr 
                85                  90                  95      

Asn Thr Phe Ile Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His 
            100                 105                 110         

Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly 
        115                 120                 125             

Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn 
    130                 135                 140                 

Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn 
145                 150                 155                 160 

Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu 
                165                 170                 175     

Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val 
            180                 185                 190         

Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn 
        195                 200                 205             

Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys 
    210                 215                 220                 

His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys 
225                 230                 235                 240 

Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn 
                245                 250                 255     

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu 
            260                 265                 270         

His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly 
        275                 280                 285             

Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala 
    290                 295                 300                 

Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe 
305                 310                 315                 320 

Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe 
                325                 330                 335     

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln 
            340                 345                 350         

Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr 
        355                 360                 365             

Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn 
    370                 375                 380                 

Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly 
385                 390                 395                 400 

Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly 
                405                 410                 415     

Val Lys Ala Pro 
            420 

<210>   84
<211>   322
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   84
Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
1               5                   10                  15      

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
            20                  25                  30          

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln 
        35                  40                  45              

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
    50                  55                  60                  

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
65                  70                  75                  80  

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
                85                  90                  95      

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
            100                 105                 110         

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
        115                 120                 125             

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
    130                 135                 140                 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
145                 150                 155                 160 

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
                165                 170                 175     

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
            180                 185                 190         

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
        195                 200                 205             

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
    210                 215                 220                 

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
225                 230                 235                 240 

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
                245                 250                 255     

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
            260                 265                 270         

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
        275                 280                 285             

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
    290                 295                 300                 

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
305                 310                 315                 320 

Leu Glu 
        

<210>   85
<211>   735
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   85
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg cctgtccgaa  60
gacaatggag tggacttcaa caaaaatacc gctctagaca aaaactatct gctgaacaat  120
aaaatcccga gcaacaacgt ggaagaagca ggctcgaaaa attacgttca ttatataatt  180
caattacagg gcaacgatat tagctacgaa gcgacgtgca acctgttttc taaaaatcca  240
aaaaacagta tcatcattca aaggaatatg aacgagtcgg cgaaatcata ctttctgagt  300
gatgacggcg aaagcatcct ggaactgaat aaatatcgaa ttcctgaacg tctgaaaaac  360
aaggaaaaag tgaaagtgac attcatcggt gcgggtaaag atgaattcaa cacttcagaa  420
tttgcccgcc tgtcggtgga tagcctttca aatgagatta gcagcttttt agacacaatt  480
aaactggata ttagcccgaa aaacgtggaa gtgaacctgt tgggcgcgaa tatgttcagt  540
tatgatttta acgtcgaaga aacctaccca ggaaagctac tcctgtcgat catggacaaa  600
atcacctcaa ccctgcctga cgtgaataaa aactccatca ccattggcgc gaatcagtat  660
gaggtgcgta tcaacagtga gggccgcaaa gaactgctag cacacagcgg taaatggatt  720
aataaagaag aagcc                                                   735

<210>   86
<211>   245
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   86
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Leu Ser Glu Asp Asn Gly Val Asp Phe Asn Lys Asn Thr Ala Leu 
            20                  25                  30          

Asp Lys Asn Tyr Leu Leu Asn Asn Lys Ile Pro Ser Asn Asn Val Glu 
        35                  40                  45              

Glu Ala Gly Ser Lys Asn Tyr Val His Tyr Ile Ile Gln Leu Gln Gly 
    50                  55                  60                  

Asn Asp Ile Ser Tyr Glu Ala Thr Cys Asn Leu Phe Ser Lys Asn Pro 
65                  70                  75                  80  

Lys Asn Ser Ile Ile Ile Gln Arg Asn Met Asn Glu Ser Ala Lys Ser 
                85                  90                  95      

Tyr Phe Leu Ser Asp Asp Gly Glu Ser Ile Leu Glu Leu Asn Lys Tyr 
            100                 105                 110         

Arg Ile Pro Glu Arg Leu Lys Asn Lys Glu Lys Val Lys Val Thr Phe 
        115                 120                 125             

Ile Gly Ala Gly Lys Asp Glu Phe Asn Thr Ser Glu Phe Ala Arg Leu 
    130                 135                 140                 

Ser Val Asp Ser Leu Ser Asn Glu Ile Ser Ser Phe Leu Asp Thr Ile 
145                 150                 155                 160 

Lys Leu Asp Ile Ser Pro Lys Asn Val Glu Val Asn Leu Leu Gly Ala 
                165                 170                 175     

Asn Met Phe Ser Tyr Asp Phe Asn Val Glu Glu Thr Tyr Pro Gly Lys 
            180                 185                 190         

Leu Leu Leu Ser Ile Met Asp Lys Ile Thr Ser Thr Leu Pro Asp Val 
        195                 200                 205             

Asn Lys Asn Ser Ile Thr Ile Gly Ala Asn Gln Tyr Glu Val Arg Ile 
    210                 215                 220                 

Asn Ser Glu Gly Arg Lys Glu Leu Leu Ala His Ser Gly Lys Trp Ile 
225                 230                 235                 240 

Asn Lys Glu Glu Ala 
                245 

<210>   87
<211>   846
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   87
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg cgaagatata  60
aatgtattta tgaaagatga tattaatact ataacaggaa aatactatgt tgataataat  120
actgataaaa gtatagattt ctctatttct ttagttagta aaaatcaagt aaaagtaaat  180
ggattatatt taaatgaatc cgtatactca tcttaccttg attttgtgaa aaattcagat  240
ggacaccata atacttctaa ttttatgaat ttatttttgg acaatataag tttctggaaa  300
ttgtttgggt ttgaaaatat aaattttgta atcgataaat actttaccct tgttggtaaa  360
actaatcttg gatatgtaga atttatttgt gacaataata aaaatataga tatatatttt  420
ggtgaatgga aaacatcgtc atctaaaagc actatattta gcggaaatgg tagaaatgtt  480
gtagtagagc ctatatataa tcctgatacg ggtgaagata tatctacttc actagatttt  540
tcctatgaac ctctctatgg aatagataga tatatcaata aagtattgat agcacctgat  600
ttatatacaa gtttaataaa tattaatacc aattattatt caaatgagta ctaccctgag  660
attatagttc ttaacccaaa tacattccac aaaaaagtaa atataaattt agatagttct  720
tcttttgagt ataaatggtc tacagaagga agtgacttta ttttagttag atacttagaa  780
gaaagtaata aaaaaatatt acaaaaaata agaatcaaag gtatcttatc taatactcaa  840
tcattt                                                             846

<210>   88
<211>   282
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   88
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Glu Asp Ile Asn Val Phe Met Lys Asp Asp Ile Asn Thr Ile Thr 
            20                  25                  30          

Gly Lys Tyr Tyr Val Asp Asn Asn Thr Asp Lys Ser Ile Asp Phe Ser 
        35                  40                  45              

Ile Ser Leu Val Ser Lys Asn Gln Val Lys Val Asn Gly Leu Tyr Leu 
    50                  55                  60                  

Asn Glu Ser Val Tyr Ser Ser Tyr Leu Asp Phe Val Lys Asn Ser Asp 
65                  70                  75                  80  

Gly His His Asn Thr Ser Asn Phe Met Asn Leu Phe Leu Asp Asn Ile 
                85                  90                  95      

Ser Phe Trp Lys Leu Phe Gly Phe Glu Asn Ile Asn Phe Val Ile Asp 
            100                 105                 110         

Lys Tyr Phe Thr Leu Val Gly Lys Thr Asn Leu Gly Tyr Val Glu Phe 
        115                 120                 125             

Ile Cys Asp Asn Asn Lys Asn Ile Asp Ile Tyr Phe Gly Glu Trp Lys 
    130                 135                 140                 

Thr Ser Ser Ser Lys Ser Thr Ile Phe Ser Gly Asn Gly Arg Asn Val 
145                 150                 155                 160 

Val Val Glu Pro Ile Tyr Asn Pro Asp Thr Gly Glu Asp Ile Ser Thr 
                165                 170                 175     

Ser Leu Asp Phe Ser Tyr Glu Pro Leu Tyr Gly Ile Asp Arg Tyr Ile 
            180                 185                 190         

Asn Lys Val Leu Ile Ala Pro Asp Leu Tyr Thr Ser Leu Ile Asn Ile 
        195                 200                 205             

Asn Thr Asn Tyr Tyr Ser Asn Glu Tyr Tyr Pro Glu Ile Ile Val Leu 
    210                 215                 220                 

Asn Pro Asn Thr Phe His Lys Lys Val Asn Ile Asn Leu Asp Ser Ser 
225                 230                 235                 240 

Ser Phe Glu Tyr Lys Trp Ser Thr Glu Gly Ser Asp Phe Ile Leu Val 
                245                 250                 255     

Arg Tyr Leu Glu Glu Ser Asn Lys Lys Ile Leu Gln Lys Ile Arg Ile 
            260                 265                 270         

Lys Gly Ile Leu Ser Asn Thr Gln Ser Phe 
        275                 280         

<210>   89
<211>   723
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   89
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg cggtgaagat  60
gacaaccttg atttctctca aaatattgtg gtcgacaagg agtatctgct ggaaaaaatt  120
tccagcttag cgcgttcgag cgagcgcggc tatattcact acatcgttca actgcagggc  180
aacaaaatca gttatgaagc ggcgtgcaac ctgtttgcga agaccccgta tgacagtgtg  240
ctatttcaaa aaaacattga agatagcgag atcgcgtact attacaatcc tggcgatggt  300
gaaattcagg aaattgacaa gtataaaatc ccgtcgatta tctctgaccg tccaaagatc  360
aaactgacgt ttatcggtgc gggtaaagat gaattcaaca ccgatatttt tgcgggtttt  420
gacgtggata gcctgtcaac ggaaattgaa gcggcgattg atttagcaaa agaggacatc  480
tccccgaaga gcattgaaat taatctgctg ggcgcgaaca tgttttcata cagcataaac  540
gtggaggaga cctatcctgg taaactgctg ttgaaagtca aagataaaat tagcgaatta  600
atgccgtcta ttagccaaga ctccatcatt gtgtcggcga atcagtacga agttcgcatt  660
aacagtgaag gccgtcgcga gctgctagat cattctggtg aatggattaa taaagaagaa  720
agt                                                                723

<210>   90
<211>   241
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   90
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Gly Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp 
            20                  25                  30          

Lys Glu Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu 
        35                  40                  45              

Arg Gly Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asn Lys Ile Ser 
    50                  55                  60                  

Tyr Glu Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val 
65                  70                  75                  80  

Leu Phe Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn 
                85                  90                  95      

Pro Gly Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser 
            100                 105                 110         

Ile Ile Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Ala Gly 
        115                 120                 125             

Lys Asp Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser 
    130                 135                 140                 

Leu Ser Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile 
145                 150                 155                 160 

Ser Pro Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser 
                165                 170                 175     

Tyr Ser Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys 
            180                 185                 190         

Val Lys Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser 
        195                 200                 205             

Ile Ile Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly 
    210                 215                 220                 

Arg Arg Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu 
225                 230                 235                 240 

Ser 
    

<210>   91
<211>   2351
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   91
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg cagtctggtt  60
aaccgtaaac aactggaaaa aatggcgaat gtgcgcttta gaacccagga agatgaatat  120
gttgcgattc tagatgcact ggaagaatac cataacatgt cagagaatac cgtggtagaa  180
aaatatctga aactgaaaga tattaactct ctgacggata tctatattga cacgtacaaa  240
aaaagcggtc gtaataaagc tctgaaaaaa tttaaggaat atctcgttac ggaagtgctg  300
gagctcaaga acaataacct gaccccggtt gagaaaaatc tgcatttcgt ttggatcggc  360
ggtcagatta acgacaccgc catcaattac attaaccagt ggaaagatgt gaatagcgat  420
tataacgtta atgtctttta tgactcgaac gcgtttctaa ttaacacgct aaaaaaaacc  480
gtggtggaaa gcgcgattaa tgatactctt gagagctttc gcgaaaacct gaacgaccca  540
cgtttcgact acaataaatt cttccgcaaa agaatggaaa ttatctatga taaacaaaaa  600
aacttcatta actactataa agcacaacgt gaagaaaatc cggaactgat tatcgacgat  660
atcgtgaaga cgtacttgag caacgagtat agcaaggaga ttgatgaact taatacatac  720
atcgaagaat cactgaacaa aatcacgcaa aatagtggca acgacgttcg caactttgag  780
gaatttaaaa atggcgagag cttcaactta tatgaacagg agctagtgga acgatggaac  840
ctggccgcag cctccgcgat tctggcgatt tctgcgctga aagaaatcgg tggtatggcg  900
ctggcggtcg cgatgctgcc gggcattcag ccggacctgt ttgagtccat tgagaaacct  960
agtagcgtga cggtagactt ctgggaaatg acgaagttag aagcaattat gaaatacaaa  1020
gaatatattc cggaatacac aagcgaacac tttgacatgc tggacgagga agttcagtcg  1080
agctttgaat ctgtcctcgc cagcaagagc gataaaagcg aaattttcag cagcctgggt  1140
gatatggagg cgagcccgct cgaagttaaa atcgcgttta attcgaaggg tatcattaac  1200
caaggactca tctccgtaaa agacagctat tgttcaaatc tgattgtgaa acagatagag  1260
aaccgctata aaattctaaa taacagtctg aatccggcaa tctcagagga caacgatttc  1320
aataccacta caaacacatt tatcgatagt attatggccg aagcaaatgc ggacaacggt  1380
cgttttatga tggaactcgg taagtacctg cgcgtcggtt tcttcccgga tgttaaaacc  1440
accatcaact tatcgggacc agaagcgtat gctgcggcct accaggatct gctgatgttt  1500
aaagaaggaa gcatgaatat acatctaatt gaagcagacc tgcgtaactt cgagatatct  1560
aaaaccaaca tctcccaaag caccgaacag gaaatggcct cactgtggag ctttgacgat  1620
gcgcgcgcaa aagcccagtt tgaagaatat aaacgaaatt actttgaagg tagcttgggt  1680
gaagatgaca accttgattt ctctcaaaat attgtggtcg acaaggagta tctgctggaa  1740
aaaatttcca gcttagcgcg ttcgagcgag cgcggctata ttcactacat cgttcaactg  1800
cagggcaaca aaatcagtta tgaagcggcg tgcaacctgt ttgcgaagac cccgtatgac  1860
agtgtgctat ttcaaaaaaa cattgaagat agcgagatcg cgtactatta caatcctggc  1920
gatggtgaaa ttcaggaaat tgacaagtat aaaatcccgt cgattatctc tgaccgtcca  1980
aagatcaaac tgacgtttat cggtgcgggt aaagatgaat tcaacaccga tatttttgcg  2040
ggttttgacg tggatagcct gtcaacggaa attgaagcgg cgattgattt agcaaaagag  2100
gacatctccc cgaagagcat tgaaattaat ctgctgggcg cgaacatgtt ttcatacagc  2160
ataaacgtgg aggagaccta tcctggtaaa ctgctgttga aagtcaaaga taaaattagc  2220
gaattaatgc cgtctattag ccaagactcc atcattgtgt cggcgaatca gtacgaagtt  2280
cgcattaaca gtgaaggccg tcgcgagctg ctagatcatt ctggtgaatg gattaataaa  2340
gaagaaagtg g                                                       2351

<210>   92
<211>   783
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   92
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
            20                  25                  30          

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
        35                  40                  45              

Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
    50                  55                  60                  

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
65                  70                  75                  80  

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
                85                  90                  95      

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
            100                 105                 110         

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
        115                 120                 125             

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
    130                 135                 140                 

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
145                 150                 155                 160 

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
                165                 170                 175     

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
            180                 185                 190         

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
        195                 200                 205             

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
    210                 215                 220                 

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
225                 230                 235                 240 

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
                245                 250                 255     

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
            260                 265                 270         

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu 
        275                 280                 285             

Ala Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala 
    290                 295                 300                 

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
305                 310                 315                 320 

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
                325                 330                 335     

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
            340                 345                 350         

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
        355                 360                 365             

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
    370                 375                 380                 

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
385                 390                 395                 400 

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
                405                 410                 415     

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
            420                 425                 430         

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
        435                 440                 445             

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
    450                 455                 460                 

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
465                 470                 475                 480 

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
                485                 490                 495     

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
            500                 505                 510         

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
        515                 520                 525             

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
    530                 535                 540                 

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu Gly 
545                 550                 555                 560 

Glu Asp Asp Asn Leu Asp Phe Ser Gln Asn Ile Val Val Asp Lys Glu 
                565                 570                 575     

Tyr Leu Leu Glu Lys Ile Ser Ser Leu Ala Arg Ser Ser Glu Arg Gly 
            580                 585                 590         

Tyr Ile His Tyr Ile Val Gln Leu Gln Gly Asn Lys Ile Ser Tyr Glu 
        595                 600                 605             

Ala Ala Cys Asn Leu Phe Ala Lys Thr Pro Tyr Asp Ser Val Leu Phe 
    610                 615                 620                 

Gln Lys Asn Ile Glu Asp Ser Glu Ile Ala Tyr Tyr Tyr Asn Pro Gly 
625                 630                 635                 640 

Asp Gly Glu Ile Gln Glu Ile Asp Lys Tyr Lys Ile Pro Ser Ile Ile 
                645                 650                 655     

Ser Asp Arg Pro Lys Ile Lys Leu Thr Phe Ile Gly Ala Gly Lys Asp 
            660                 665                 670         

Glu Phe Asn Thr Asp Ile Phe Ala Gly Phe Asp Val Asp Ser Leu Ser 
        675                 680                 685             

Thr Glu Ile Glu Ala Ala Ile Asp Leu Ala Lys Glu Asp Ile Ser Pro 
    690                 695                 700                 

Lys Ser Ile Glu Ile Asn Leu Leu Gly Ala Asn Met Phe Ser Tyr Ser 
705                 710                 715                 720 

Ile Asn Val Glu Glu Thr Tyr Pro Gly Lys Leu Leu Leu Lys Val Lys 
                725                 730                 735     

Asp Lys Ile Ser Glu Leu Met Pro Ser Ile Ser Gln Asp Ser Ile Ile 
            740                 745                 750         

Val Ser Ala Asn Gln Tyr Glu Val Arg Ile Asn Ser Glu Gly Arg Arg 
        755                 760                 765             

Glu Leu Leu Asp His Ser Gly Glu Trp Ile Asn Lys Glu Glu Ser 
    770                 775                 780             

<210>   93
<211>   1677
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   93
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg cagtctggtt  60
aaccgtaaac aactggaaaa aatggcgaat gtgcgcttta gaacccagga agatgaatat  120
gttgcgattc tagatgcact ggaagaatac cataacatgt cagagaatac cgtggtagaa  180
aaatatctga aactgaaaga tattaactct ctgacggata tctatattga cacgtacaaa  240
aaaagcggtc gtaataaagc tctgaaaaaa tttaaggaat atctcgttac ggaagtgctg  300
gagctcaaga acaataacct gaccccggtt gagaaaaatc tgcatttcgt ttggatcggc  360
ggtcagatta acgacaccgc catcaattac attaaccagt ggaaagatgt gaatagcgat  420
tataacgtta atgtctttta tgactcgaac gcgtttctaa ttaacacgct aaaaaaaacc  480
gtggtggaaa gcgcgattaa tgatactctt gagagctttc gcgaaaacct gaacgaccca  540
cgtttcgact acaataaatt cttccgcaaa agaatggaaa ttatctatga taaacaaaaa  600
aacttcatta actactataa agcacaacgt gaagaaaatc cggaactgat tatcgacgat  660
atcgtgaaga cgtacttgag caacgagtat agcaaggaga ttgatgaact taatacatac  720
atcgaagaat cactgaacaa aatcacgcaa aatagtggca acgacgttcg caactttgag  780
gaatttaaaa atggcgagag cttcaactta tatgaacagg agctagtgga acgatggaac  840
ctggccgcag cctccgcgat tctggcgatt tctgcgctga aagaaatcgg tggtatggcg  900
ctggcggtcg cgatgctgcc gggcattcag ccggacctgt ttgagtccat tgagaaacct  960
agtagcgtga cggtagactt ctgggaaatg acgaagttag aagcaattat gaaatacaaa  1020
gaatatattc cggaatacac aagcgaacac tttgacatgc tggacgagga agttcagtcg  1080
agctttgaat ctgtcctcgc cagcaagagc gataaaagcg aaattttcag cagcctgggt  1140
gatatggagg cgagcccgct cgaagttaaa atcgcgttta attcgaaggg tatcattaac  1200
caaggactca tctccgtaaa agacagctat tgttcaaatc tgattgtgaa acagatagag  1260
aaccgctata aaattctaaa taacagtctg aatccggcaa tctcagagga caacgatttc  1320
aataccacta caaacacatt tatcgatagt attatggccg aagcaaatgc ggacaacggt  1380
cgttttatga tggaactcgg taagtacctg cgcgtcggtt tcttcccgga tgttaaaacc  1440
accatcaact tatcgggacc agaagcgtat gctgcggcct accaggatct gctgatgttt  1500
aaagaaggaa gcatgaatat acatctaatt gaagcagacc tgcgtaactt cgagatatct  1560
aaaaccaaca tctcccaaag caccgaacag gaaatggcct cactgtggag ctttgacgat  1620
gcgcgcgcaa aagcccagtt tgaagaatat aaacgaaatt actttgaagg tagcttg     1677

<210>   94
<211>   559
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   94
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Ser Leu Val Asn Arg Lys Gln Leu Glu Lys Met Ala Asn Val Arg 
            20                  25                  30          

Phe Arg Thr Gln Glu Asp Glu Tyr Val Ala Ile Leu Asp Ala Leu Glu 
        35                  40                  45              

Glu Tyr His Asn Met Ser Glu Asn Thr Val Val Glu Lys Tyr Leu Lys 
    50                  55                  60                  

Leu Lys Asp Ile Asn Ser Leu Thr Asp Ile Tyr Ile Asp Thr Tyr Lys 
65                  70                  75                  80  

Lys Ser Gly Arg Asn Lys Ala Leu Lys Lys Phe Lys Glu Tyr Leu Val 
                85                  90                  95      

Thr Glu Val Leu Glu Leu Lys Asn Asn Asn Leu Thr Pro Val Glu Lys 
            100                 105                 110         

Asn Leu His Phe Val Trp Ile Gly Gly Gln Ile Asn Asp Thr Ala Ile 
        115                 120                 125             

Asn Tyr Ile Asn Gln Trp Lys Asp Val Asn Ser Asp Tyr Asn Val Asn 
    130                 135                 140                 

Val Phe Tyr Asp Ser Asn Ala Phe Leu Ile Asn Thr Leu Lys Lys Thr 
145                 150                 155                 160 

Val Val Glu Ser Ala Ile Asn Asp Thr Leu Glu Ser Phe Arg Glu Asn 
                165                 170                 175     

Leu Asn Asp Pro Arg Phe Asp Tyr Asn Lys Phe Phe Arg Lys Arg Met 
            180                 185                 190         

Glu Ile Ile Tyr Asp Lys Gln Lys Asn Phe Ile Asn Tyr Tyr Lys Ala 
        195                 200                 205             

Gln Arg Glu Glu Asn Pro Glu Leu Ile Ile Asp Asp Ile Val Lys Thr 
    210                 215                 220                 

Tyr Leu Ser Asn Glu Tyr Ser Lys Glu Ile Asp Glu Leu Asn Thr Tyr 
225                 230                 235                 240 

Ile Glu Glu Ser Leu Asn Lys Ile Thr Gln Asn Ser Gly Asn Asp Val 
                245                 250                 255     

Arg Asn Phe Glu Glu Phe Lys Asn Gly Glu Ser Phe Asn Leu Tyr Glu 
            260                 265                 270         

Gln Glu Leu Val Glu Arg Trp Asn Leu Ala Ala Ala Ser Ala Ile Leu 
        275                 280                 285             

Ala Ile Ser Ala Leu Lys Glu Ile Gly Gly Met Ala Leu Ala Val Ala 
    290                 295                 300                 

Met Leu Pro Gly Ile Gln Pro Asp Leu Phe Glu Ser Ile Glu Lys Pro 
305                 310                 315                 320 

Ser Ser Val Thr Val Asp Phe Trp Glu Met Thr Lys Leu Glu Ala Ile 
                325                 330                 335     

Met Lys Tyr Lys Glu Tyr Ile Pro Glu Tyr Thr Ser Glu His Phe Asp 
            340                 345                 350         

Met Leu Asp Glu Glu Val Gln Ser Ser Phe Glu Ser Val Leu Ala Ser 
        355                 360                 365             

Lys Ser Asp Lys Ser Glu Ile Phe Ser Ser Leu Gly Asp Met Glu Ala 
    370                 375                 380                 

Ser Pro Leu Glu Val Lys Ile Ala Phe Asn Ser Lys Gly Ile Ile Asn 
385                 390                 395                 400 

Gln Gly Leu Ile Ser Val Lys Asp Ser Tyr Cys Ser Asn Leu Ile Val 
                405                 410                 415     

Lys Gln Ile Glu Asn Arg Tyr Lys Ile Leu Asn Asn Ser Leu Asn Pro 
            420                 425                 430         

Ala Ile Ser Glu Asp Asn Asp Phe Asn Thr Thr Thr Asn Thr Phe Ile 
        435                 440                 445             

Asp Ser Ile Met Ala Glu Ala Asn Ala Asp Asn Gly Arg Phe Met Met 
    450                 455                 460                 

Glu Leu Gly Lys Tyr Leu Arg Val Gly Phe Phe Pro Asp Val Lys Thr 
465                 470                 475                 480 

Thr Ile Asn Leu Ser Gly Pro Glu Ala Tyr Ala Ala Ala Tyr Gln Asp 
                485                 490                 495     

Leu Leu Met Phe Lys Glu Gly Ser Met Asn Ile His Leu Ile Glu Ala 
            500                 505                 510         

Asp Leu Arg Asn Phe Glu Ile Ser Lys Thr Asn Ile Ser Gln Ser Thr 
        515                 520                 525             

Glu Gln Glu Met Ala Ser Leu Trp Ser Phe Asp Asp Ala Arg Ala Lys 
    530                 535                 540                 

Ala Gln Phe Glu Glu Tyr Lys Arg Asn Tyr Phe Glu Gly Ser Leu 
545                 550                 555                 

<210>   95
<211>   1599
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   95
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg cattaccggc  60
ttcgtaaccg tgggagacga taaatactac tttaacccga tcaatggtgg tgccgcaagc  120
atcggcgaga cgattatcga tgacaaaaac tattatttca accagagcgg cgtactgcaa  180
acgggtgtgt tttcgacgga ggacggcttc aaatactttg ctccggccaa tactctggat  240
gaaaacctcg aaggcgaagc gatcgatttt accggtaaac tgatcatcga cgaaaacatc  300
tattattttg acgataatta ccgtggcgca gtggaatgga aagaactgga tggtgagatg  360
cactatttct caccggaaac gggtaaagcc tttaaaggtc tcaaccagat tggtgactac  420
aaatactatt tcaattccga tggcgtcatg cagaaaggct ttgttagtat taacgataat  480
aaacactatt ttgacgattc tggtgtcatg aaagtgggtt acaccgaaat tgatggaaag  540
catttctact tcgcagaaaa cggcgaaatg cagattggtg tgtttaacac ggaagacggc  600
tttaaatact tcgcccacca taatgaagat ttaggcaacg aagagggtga agaaataagc  660
tattccggta ttctgaattt caacaataaa atctactact ttgatgacag ctttactgca  720
gtggttggct ggaaagatct ggaggacggt agcaagtatt atttcgatga agatacggcg  780
gaagcgtaca ttggtctaag cctgattaac gacggtcaat attactttaa tgatgatggc  840
atcatgcagg tcggttttgt aaccattaac gacaaagtat tctacttcag cgactctggc  900
atcattgaat ccggcgtgca gaacattgat gacaattatt tctatattga tgacaacggt  960
attgttcaga tcggtgtgtt tgataccagc gatggctaca aatatttcgc gccggccaat  1020
accgtgaacg acaatatcta cggccaagcg gtcgaatata gtggtctggt tcgcgtcggt  1080
gaagatgtgt actattttgg tgagacgtat actatcgaga ccggctggat ttacgatatg  1140
gaaaacgaat cggacaaata ttacttcaat ccggaaacca aaaaagcgtg caaaggtatc  1200
aacctgatcg atgatattaa atattatttt gacgagaagg gaattatgcg tacaggtttg  1260
attagcttcg aaaataacaa ttactacttt aacgagaatg gtgaaatgca gtttggttat  1320
attaacattg aagataagat gttctacttt ggtgaagatg gtgtaatgca aatcggcgtg  1380
ttcaatacgc cggacggctt taaatacttt gcgcatcaga acaccctaga tgagaatttt  1440
gagggcgaga gcattaacta taccggttgg ctggatttag acgaaaagcg ctactatttc  1500
acggatgaat atatcgcggc gaccggtagc gttatcatcg atggtgagga gtactatttt  1560
gaccctgata cggcacaact ggtaatcagc gaactcgag                         1599

<210>   96
<211>   533
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   96
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Ile Thr Gly Phe Val Thr Val Gly Asp Asp Lys Tyr Tyr Phe Asn 
            20                  25                  30          

Pro Ile Asn Gly Gly Ala Ala Ser Ile Gly Glu Thr Ile Ile Asp Asp 
        35                  40                  45              

Lys Asn Tyr Tyr Phe Asn Gln Ser Gly Val Leu Gln Thr Gly Val Phe 
    50                  55                  60                  

Ser Thr Glu Asp Gly Phe Lys Tyr Phe Ala Pro Ala Asn Thr Leu Asp 
65                  70                  75                  80  

Glu Asn Leu Glu Gly Glu Ala Ile Asp Phe Thr Gly Lys Leu Ile Ile 
                85                  90                  95      

Asp Glu Asn Ile Tyr Tyr Phe Asp Asp Asn Tyr Arg Gly Ala Val Glu 
            100                 105                 110         

Trp Lys Glu Leu Asp Gly Glu Met His Tyr Phe Ser Pro Glu Thr Gly 
        115                 120                 125             

Lys Ala Phe Lys Gly Leu Asn Gln Ile Gly Asp Tyr Lys Tyr Tyr Phe 
    130                 135                 140                 

Asn Ser Asp Gly Val Met Gln Lys Gly Phe Val Ser Ile Asn Asp Asn 
145                 150                 155                 160 

Lys His Tyr Phe Asp Asp Ser Gly Val Met Lys Val Gly Tyr Thr Glu 
                165                 170                 175     

Ile Asp Gly Lys His Phe Tyr Phe Ala Glu Asn Gly Glu Met Gln Ile 
            180                 185                 190         

Gly Val Phe Asn Thr Glu Asp Gly Phe Lys Tyr Phe Ala His His Asn 
        195                 200                 205             

Glu Asp Leu Gly Asn Glu Glu Gly Glu Glu Ile Ser Tyr Ser Gly Ile 
    210                 215                 220                 

Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp Asp Ser Phe Thr Ala 
225                 230                 235                 240 

Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser Lys Tyr Tyr Phe Asp 
                245                 250                 255     

Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser Leu Ile Asn Asp Gly 
            260                 265                 270         

Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln Val Gly Phe Val Thr 
        275                 280                 285             

Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser Gly Ile Ile Glu Ser 
    290                 295                 300                 

Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr Ile Asp Asp Asn Gly 
305                 310                 315                 320 

Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe 
                325                 330                 335     

Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu 
            340                 345                 350         

Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu 
        355                 360                 365             

Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser 
    370                 375                 380                 

Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile 
385                 390                 395                 400 

Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met 
                405                 410                 415     

Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu 
            420                 425                 430         

Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe 
        435                 440                 445             

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro 
    450                 455                 460                 

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe 
465                 470                 475                 480 

Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys 
                485                 490                 495     

Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile 
            500                 505                 510         

Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val 
        515                 520                 525             

Ile Ser Glu Leu Glu 
    530             

<210>   97
<211>   687
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   97
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg cgttcagatc  60
ggtgtgtttg ataccagcga tggctacaaa tatttcgcgc cggccaatac cgtgaacgac  120
aatatctacg gccaagcggt cgaatatagt ggtctggttc gcgtcggtga agatgtgtac  180
tattttggtg agacgtatac tatcgagacc ggctggattt acgatatgga aaacgaatcg  240
gacaaatatt acttcaatcc ggaaaccaaa aaagcgtgca aaggtatcaa cctgatcgat  300
gatattaaat attattttga cgagaaggga attatgcgta caggtttgat tagcttcgaa  360
aataacaatt actactttaa cgagaatggt gaaatgcagt ttggttatat taacattgaa  420
gataagatgt tctactttgg tgaagatggt gtaatgcaaa tcggcgtgtt caatacgccg  480
gacggcttta aatactttgc gcatcagaac accctagatg agaattttga gggcgagagc  540
attaactata ccggttggct ggatttagac gaaaagcgct actatttcac ggatgaatat  600
atcgcggcga ccggtagcgt tatcatcgat ggtgaggagt actattttga ccctgatacg  660
gcacaactgg taatcagcga actcgag                                      687

<210>   98
<211>   229
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   98
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Val Gln Ile Gly Val Phe Asp Thr Ser Asp Gly Tyr Lys Tyr Phe 
            20                  25                  30          

Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr Gly Gln Ala Val Glu 
        35                  40                  45              

Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val Tyr Tyr Phe Gly Glu 
    50                  55                  60                  

Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp Met Glu Asn Glu Ser 
65                  70                  75                  80  

Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys Ala Cys Lys Gly Ile 
                85                  90                  95      

Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp Glu Lys Gly Ile Met 
            100                 105                 110         

Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn Tyr Tyr Phe Asn Glu 
        115                 120                 125             

Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile Glu Asp Lys Met Phe 
    130                 135                 140                 

Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly Val Phe Asn Thr Pro 
145                 150                 155                 160 

Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr Leu Asp Glu Asn Phe 
                165                 170                 175     

Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu Asp Leu Asp Glu Lys 
            180                 185                 190         

Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala Thr Gly Ser Val Ile 
        195                 200                 205             

Ile Asp Gly Glu Glu Tyr Tyr Phe Asp Pro Asp Thr Ala Gln Leu Val 
    210                 215                 220                 

Ile Ser Glu Leu Glu 
225                 

<210>   99
<211>   915
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   99
atgggcagca gccatcatca tcatcatcac gaaaacctgt acttccaggg ctattctggt  60
atattaaatt tcaataataa aatttactat tttgatgatt catttacagc tgtagttgga  120
tggaaagatt tagaggatgg ttcaaagtat tattttgatg aagatacagc agaagcatat  180
ataggtttgt cattaataaa tgatggtcaa tattatttta atgatgatgg aattatgcaa  240
gttggatttg tcactataaa tgataaagtc ttctacttct ctgactctgg aattatagaa  300
tctggagtac aaaacataga tgacaattat ttctatatag atgataatgg tatagttcaa  360
attggtgtat ttgatacttc agatggatat aaatattttg cacctgctaa tactgtaaat  420
gataatattt acggacaagc agttgaatat agtggtttag ttagagttgg tgaagatgta  480
tattattttg gagaaacata tacaattgag actggatgga tatatgatat ggaaaatgaa  540
agtgataaat attatttcaa tccagaaact aaaaaagcat gcaaaggtat taatttaatt  600
gatgatataa aatattattt tgatgagaag ggcataatga gaacgggtct tatatcattt  660
gaaaataata attattactt taatgagaat ggtgaaatgc aatttggtta tataaatata  720
gaagataaga tgttctattt tggtgaagat ggtgtcatgc agattggagt atttaataca  780
ccagatggat ttaaatactt tgcacatcaa aatactttgg atgagaattt tgagggagaa  840
tcaataaact atactggttg gttagattta gatgaaaaga gatattattt tacagatgaa  900
tatattgcag caact                                                   915

<210>   100
<211>   305
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   100
Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      

Gly Tyr Ser Gly Ile Leu Asn Phe Asn Asn Lys Ile Tyr Tyr Phe Asp 
            20                  25                  30          

Asp Ser Phe Thr Ala Val Val Gly Trp Lys Asp Leu Glu Asp Gly Ser 
        35                  40                  45              

Lys Tyr Tyr Phe Asp Glu Asp Thr Ala Glu Ala Tyr Ile Gly Leu Ser 
    50                  55                  60                  

Leu Ile Asn Asp Gly Gln Tyr Tyr Phe Asn Asp Asp Gly Ile Met Gln 
65                  70                  75                  80  

Val Gly Phe Val Thr Ile Asn Asp Lys Val Phe Tyr Phe Ser Asp Ser 
                85                  90                  95      

Gly Ile Ile Glu Ser Gly Val Gln Asn Ile Asp Asp Asn Tyr Phe Tyr 
            100                 105                 110         

Ile Asp Asp Asn Gly Ile Val Gln Ile Gly Val Phe Asp Thr Ser Asp 
        115                 120                 125             

Gly Tyr Lys Tyr Phe Ala Pro Ala Asn Thr Val Asn Asp Asn Ile Tyr 
    130                 135                 140                 

Gly Gln Ala Val Glu Tyr Ser Gly Leu Val Arg Val Gly Glu Asp Val 
145                 150                 155                 160 

Tyr Tyr Phe Gly Glu Thr Tyr Thr Ile Glu Thr Gly Trp Ile Tyr Asp 
                165                 170                 175     

Met Glu Asn Glu Ser Asp Lys Tyr Tyr Phe Asn Pro Glu Thr Lys Lys 
            180                 185                 190         

Ala Cys Lys Gly Ile Asn Leu Ile Asp Asp Ile Lys Tyr Tyr Phe Asp 
        195                 200                 205             

Glu Lys Gly Ile Met Arg Thr Gly Leu Ile Ser Phe Glu Asn Asn Asn 
    210                 215                 220                 

Tyr Tyr Phe Asn Glu Asn Gly Glu Met Gln Phe Gly Tyr Ile Asn Ile 
225                 230                 235                 240 

Glu Asp Lys Met Phe Tyr Phe Gly Glu Asp Gly Val Met Gln Ile Gly 
                245                 250                 255     

Val Phe Asn Thr Pro Asp Gly Phe Lys Tyr Phe Ala His Gln Asn Thr 
            260                 265                 270         

Leu Asp Glu Asn Phe Glu Gly Glu Ser Ile Asn Tyr Thr Gly Trp Leu 
        275                 280                 285             

Asp Leu Asp Glu Lys Arg Tyr Tyr Phe Thr Asp Glu Tyr Ile Ala Ala 
    290                 295                 300                 

Thr 
305 

<210>   101
<211>   320
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   101
Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
1               5                   10                  15      

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
            20                  25                  30          

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Asn Asn Asn Ile Glu Gly Gln 
        35                  40                  45              

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
    50                  55                  60                  

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
65                  70                  75                  80  

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
                85                  90                  95      

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
            100                 105                 110         

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
        115                 120                 125             

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
    130                 135                 140                 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
145                 150                 155                 160 

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
                165                 170                 175     

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
            180                 185                 190         

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
        195                 200                 205             

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
    210                 215                 220                 

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
225                 230                 235                 240 

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
                245                 250                 255     

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
            260                 265                 270         

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
        275                 280                 285             

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
    290                 295                 300                 

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
305                 310                 315                 320 

<210>   102
<211>   320
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   102
Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
1               5                   10                  15      

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
            20                  25                  30          

Glu Tyr Phe Ala Pro Ala Asn Thr His Ala Asn Asn Ile Glu Gly Gln 
        35                  40                  45              

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
    50                  55                  60                  

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
65                  70                  75                  80  

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
                85                  90                  95      

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
            100                 105                 110         

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
        115                 120                 125             

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
    130                 135                 140                 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
145                 150                 155                 160 

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
                165                 170                 175     

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
            180                 185                 190         

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
        195                 200                 205             

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
    210                 215                 220                 

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
225                 230                 235                 240 

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
                245                 250                 255     

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
            260                 265                 270         

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
        275                 280                 285             

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
    290                 295                 300                 

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
305                 310                 315                 320 

<210>   103
<211>   320
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   103
Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
1               5                   10                  15      

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
            20                  25                  30          

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln 
        35                  40                  45              

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
    50                  55                  60                  

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
65                  70                  75                  80  

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
                85                  90                  95      

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
            100                 105                 110         

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
        115                 120                 125             

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
    130                 135                 140                 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
145                 150                 155                 160 

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
                165                 170                 175     

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
            180                 185                 190         

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
        195                 200                 205             

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
    210                 215                 220                 

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
225                 230                 235                 240 

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
                245                 250                 255     

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
            260                 265                 270         

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
        275                 280                 285             

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
    290                 295                 300                 

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
305                 310                 315                 320 

<210>   104
<211>   41
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   104
Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      

Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          

Arg Trp Gly Ser Ser Arg Ile Thr Arg 
        35                  40      

<210>   105
<211>   9
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<220>
<221>   Xaa
<222>   7
<223>   Any amino acid

<400>   105
Thr Glu Ser Thr Cys Arg Xaa Gln Ala 
1               5                   

<210>   106
<211>   361
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   106
Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      

Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          

Arg Trp Gly Ser Ser Arg Ile Thr Arg Ala Ser Thr Gly Tyr Thr Ser 
        35                  40                  45              

Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile 
    50                  55                  60                  

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
65                  70                  75                  80  

Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys 
                85                  90                  95      

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys 
            100                 105                 110         

Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
        115                 120                 125             

Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys 
    130                 135                 140                 

Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr 
145                 150                 155                 160 

Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
                165                 170                 175     

Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala 
            180                 185                 190         

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn 
        195                 200                 205             

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser 
    210                 215                 220                 

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe 
225                 230                 235                 240 

Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn 
                245                 250                 255     

Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys 
            260                 265                 270         

Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn 
        275                 280                 285             

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu 
    290                 295                 300                 

Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly 
305                 310                 315                 320 

Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala 
                325                 330                 335     

Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe 
            340                 345                 350         

Phe Gly Val Asp Gly Val Lys Ala Pro 
        355                 360     

<210>   107
<211>   329
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<220>
<221>   Xaa
<222>   327
<223>   Any amino acid

<400>   107
Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
1               5                   10                  15      

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
            20                  25                  30          

Glu Tyr Phe Ala Pro Ala Asn Thr His Asn Asn Asn Ile Glu Gly Gln 
        35                  40                  45              

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
    50                  55                  60                  

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
65                  70                  75                  80  

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
                85                  90                  95      

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
            100                 105                 110         

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
        115                 120                 125             

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
    130                 135                 140                 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
145                 150                 155                 160 

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
                165                 170                 175     

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
            180                 185                 190         

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
        195                 200                 205             

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
    210                 215                 220                 

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
225                 230                 235                 240 

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
                245                 250                 255     

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
            260                 265                 270         

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
        275                 280                 285             

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
    290                 295                 300                 

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
305                 310                 315                 320 

Thr Glu Ser Thr Cys Arg Xaa Gln Ala 
                325                 

<210>   108
<211>   370
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<220>
<221>   Xaa
<222>   368
<223>   Any amino acid

<400>   108
Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      

Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          

Arg Trp Gly Ser Ser Arg Ile Thr Arg Ala Ser Thr Gly Tyr Thr Ser 
        35                  40                  45              

Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile 
    50                  55                  60                  

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
65                  70                  75                  80  

Thr His Asn Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys 
                85                  90                  95      

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys 
            100                 105                 110         

Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
        115                 120                 125             

Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys 
    130                 135                 140                 

Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr 
145                 150                 155                 160 

Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
                165                 170                 175     

Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala 
            180                 185                 190         

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn 
        195                 200                 205             

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser 
    210                 215                 220                 

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe 
225                 230                 235                 240 

Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn 
                245                 250                 255     

Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys 
            260                 265                 270         

Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn 
        275                 280                 285             

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu 
    290                 295                 300                 

Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly 
305                 310                 315                 320 

Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala 
                325                 330                 335     

Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe 
            340                 345                 350         

Phe Gly Val Asp Gly Val Lys Ala Pro Thr Glu Ser Thr Cys Arg Xaa 
        355                 360                 365             

Gln Ala 
    370 

<210>   109
<211>   361
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<400>   109
Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      

Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          

Arg Trp Gly Ser Ser Arg Ile Thr Arg Ala Ser Thr Gly Tyr Thr Ser 
        35                  40                  45              

Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile 
    50                  55                  60                  

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
65                  70                  75                  80  

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys 
                85                  90                  95      

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys 
            100                 105                 110         

Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
        115                 120                 125             

Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys 
    130                 135                 140                 

Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr 
145                 150                 155                 160 

Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
                165                 170                 175     

Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala 
            180                 185                 190         

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn 
        195                 200                 205             

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser 
    210                 215                 220                 

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe 
225                 230                 235                 240 

Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn 
                245                 250                 255     

Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys 
            260                 265                 270         

Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn 
        275                 280                 285             

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu 
    290                 295                 300                 

Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly 
305                 310                 315                 320 

Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala 
                325                 330                 335     

Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe 
            340                 345                 350         

Phe Gly Val Asp Gly Val Lys Ala Pro 
        355                 360     

<210>   110
<211>   329
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<220>
<221>   Xaa
<222>   327
<223>   Any amino acid

<400>   110
Ala Ser Thr Gly Tyr Thr Ser Ile Asn Gly Lys His Phe Tyr Phe Asn 
1               5                   10                  15      

Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asn Gly Phe 
            20                  25                  30          

Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln 
        35                  40                  45              

Ala Ile Leu Tyr Gln Asn Lys Phe Leu Thr Leu Asn Gly Lys Lys Tyr 
    50                  55                  60                  

Tyr Phe Gly Ser Asp Ser Lys Ala Val Thr Gly Leu Arg Thr Ile Asp 
65                  70                  75                  80  

Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ala Val Ala Val Thr Gly 
                85                  90                  95      

Trp Gln Thr Ile Asn Gly Lys Lys Tyr Tyr Phe Asn Thr Asn Thr Ser 
            100                 105                 110         

Ile Ala Ser Thr Gly Tyr Thr Ile Ile Ser Gly Lys His Phe Tyr Phe 
        115                 120                 125             

Asn Thr Asp Gly Ile Met Gln Ile Gly Val Phe Lys Gly Pro Asp Gly 
    130                 135                 140                 

Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly 
145                 150                 155                 160 

Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu Tyr Leu His Asp Asn Ile 
                165                 170                 175     

Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Ala Thr Gly Trp Val Thr Ile 
            180                 185                 190         

Asp Gly Asn Arg Tyr Tyr Phe Glu Pro Asn Thr Ala Met Gly Ala Asn 
        195                 200                 205             

Gly Tyr Lys Thr Ile Asp Asn Lys Asn Phe Tyr Phe Arg Asn Gly Leu 
    210                 215                 220                 

Pro Gln Ile Gly Val Phe Lys Gly Ser Asn Gly Phe Glu Tyr Phe Ala 
225                 230                 235                 240 

Pro Ala Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr 
                245                 250                 255     

Gln Asn Arg Phe Leu His Leu Leu Gly Lys Ile Tyr Tyr Phe Gly Asn 
            260                 265                 270         

Asn Ser Lys Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys Val Tyr 
        275                 280                 285             

Tyr Phe Met Pro Asp Thr Ala Met Ala Ala Ala Gly Gly Leu Phe Glu 
    290                 295                 300                 

Ile Asp Gly Val Ile Tyr Phe Phe Gly Val Asp Gly Val Lys Ala Pro 
305                 310                 315                 320 

Thr Glu Ser Thr Cys Arg Xaa Gln Ala 
                325                 

<210>   111
<211>   370
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Sequence

<220>
<221>   Xaa
<222>   368
<223>   Any amino acid

<400>   111
Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      

Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          

Arg Trp Gly Ser Ser Arg Ile Thr Arg Ala Ser Thr Gly Tyr Thr Ser 
        35                  40                  45              

Ile Asn Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln Ile 
    50                  55                  60                  

Gly Val Phe Lys Gly Pro Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn 
65                  70                  75                  80  

Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Leu Tyr Gln Asn Lys 
                85                  90                  95      

Phe Leu Thr Leu Asn Gly Lys Lys Tyr Tyr Phe Gly Ser Asp Ser Lys 
            100                 105                 110         

Ala Val Thr Gly Leu Arg Thr Ile Asp Gly Lys Lys Tyr Tyr Phe Asn 
        115                 120                 125             

Thr Asn Thr Ala Val Ala Val Thr Gly Trp Gln Thr Ile Asn Gly Lys 
    130                 135                 140                 

Lys Tyr Tyr Phe Asn Thr Asn Thr Ser Ile Ala Ser Thr Gly Tyr Thr 
145                 150                 155                 160 

Ile Ile Ser Gly Lys His Phe Tyr Phe Asn Thr Asp Gly Ile Met Gln 
                165                 170                 175     

Ile Gly Val Phe Lys Gly Pro Asp Gly Phe Glu Tyr Phe Ala Pro Ala 
            180                 185                 190         

Asn Thr Asp Ala Asn Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn 
        195                 200                 205             

Arg Phe Leu Tyr Leu His Asp Asn Ile Tyr Tyr Phe Gly Asn Asn Ser 
    210                 215                 220                 

Lys Ala Ala Thr Gly Trp Val Thr Ile Asp Gly Asn Arg Tyr Tyr Phe 
225                 230                 235                 240 

Glu Pro Asn Thr Ala Met Gly Ala Asn Gly Tyr Lys Thr Ile Asp Asn 
                245                 250                 255     

Lys Asn Phe Tyr Phe Arg Asn Gly Leu Pro Gln Ile Gly Val Phe Lys 
            260                 265                 270         

Gly Ser Asn Gly Phe Glu Tyr Phe Ala Pro Ala Asn Thr Asp Ala Asn 
        275                 280                 285             

Asn Ile Glu Gly Gln Ala Ile Arg Tyr Gln Asn Arg Phe Leu His Leu 
    290                 295                 300                 

Leu Gly Lys Ile Tyr Tyr Phe Gly Asn Asn Ser Lys Ala Val Thr Gly 
305                 310                 315                 320 

Trp Gln Thr Ile Asn Gly Lys Val Tyr Tyr Phe Met Pro Asp Thr Ala 
                325                 330                 335     

Met Ala Ala Ala Gly Gly Leu Phe Glu Ile Asp Gly Val Ile Tyr Phe 
            340                 345                 350         

Phe Gly Val Asp Gly Val Lys Ala Pro Thr Glu Ser Thr Cys Arg Xaa 
        355                 360                 365             

Gln Ala 
    370 

<210>   112
<211>   1113
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence

<220>
<221>   n
<222>   (1102)...(1103)
<223>   Any nucleotide

<400>   112
atgcggggtt ctcatcatca tcatcatcat ggtatggcta gcatgactgg tggacagcaa  60
atgggtcggg atctgtacga cgatgacgat aaggatcgat ggggatcctc tagaatcact  120
agagcctcaa ctggttatac aagtattaat ggtaaacatt tttattttaa tactgatggt  180
attatgcaga taggagtgtt taaaggacct aatggatttg aatactttgc acctgctaat  240
acggatgcta acaacataga aggtcaagct atactttacc aaaataaatt cttaactttg  300
aatggtaaaa aatattactt tggtagtgac tcaaaagcag ttaccggact gcgaactatt  360
gatggtaaaa aatattactt taatactaac actgctgttg cagttactgg atggcaaact  420
attaatggta aaaaatacta ctttaatact aacacttcta tagcttcaac tggttataca  480
attattagtg gtaaacattt ttattttaat actgatggta ttatgcagat aggagtgttt  540
aaaggacctg atggatttga atactttgca cctgctaata cagatgctaa caatatagaa  600
ggtcaagcta tacgttatca aaatagattc ctatatttac atgacaatat atattatttt  660
ggtaataatt caaaagcggc tactggttgg gtaactattg atggtaatag atattacttc  720
gagcctaata cagctatggg tgcgaatggt tataaaacta ttgataataa aaatttttac  780
tttagaaatg gtttacctca gataggagtg tttaaagggt ctaatggatt tgaatacttt  840
gcacctgcta atacggatgc taacaatata gaaggtcaag ctatacgtta tcaaaataga  900
ttcctacatt tacttggaaa aatatattac tttggtaata attcaaaagc agttactgga  960
tggcaaacta ttaatggtaa agtatattac tttatgcctg atactgctat ggctgcagct  1020
ggtggacttt tcgagattga tggtgttata tatttctttg gtgttgatgg agtaaaagcc  1080
cctacagagt cgacctgcag gnngcaagct tga                               1113

