	SEQUENCE LISTING

<110>  THE INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
       NATIONAL RESEARCH COUNCIL OF CANADA
 
<120>  SOLUBLE IGF RECEPTOR Fc FUSION PROTEINS AND USES THEREOF

<130>  05001770-467PCT

<150>  US 61/576,034
<151>  2011-12-15

<160>  18    

<170>  PatentIn version 3.5

<210> 1
<211> 933
<212> PRT
<213> Artificial Sequence

<220> 
<223> sIGFIR933 protein sequence

<400> 1
Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu
 1               5                  10                  15      
Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile
            20                  25                  30          
Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg
        35                  40                  45              
Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile
    50                  55                  60                  
Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val
65                  70                  75                  80  
Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu
                85                  90                  95      
Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe
            100                 105                 110         
Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile
        115                 120                 125             
Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu
    130                 135                 140                 
Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile
145                 150                 155                 160 
Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys
                165                 170                 175     
Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys
            180                 185                 190         
Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr
        195                 200                 205             
Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys
    210                 215                 220                 
Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser
225                 230                 235                 240 
Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr
                245                 250                 255     
Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu
            260                 265                 270         
Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala
        275                 280                 285             
Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met
    290                 295                 300                 
Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr
305                 310                 315                 320 
Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys
                325                 330                 335     
Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly
            340                 345                 350         
Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn
        355                 360                 365             
Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val
    370                 375                 380                 
Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser
385                 390                 395                 400 
Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly
                405                 410                 415     
Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp
            420                 425                 430         
Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe
        435                 440                 445             
Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu
    450                 455                 460                 
Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg
465                 470                 475                 480 
Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr
                485                 490                 495     
Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr
            500                 505                 510         
Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys
        515                 520                 525             
Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys
    530                 535                 540                 
Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys
545                 550                 555                 560 
Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln
                565                 570                 575     
Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp
            580                 585                 590         
His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala
        595                 600                 605             
Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser
    610                 615                 620                 
Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn
625                 630                 635                 640 
Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr
                645                 650                 655     
Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys
            660                 665                 670         
Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys
        675                 680                 685             
Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys
    690                 695                 700                 
Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys
705                 710                 715                 720 
Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu
                725                 730                 735     
Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser
            740                 745                 750         
Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro
        755                 760                 765             
Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn
    770                 775                 780                 
Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg
785                 790                 795                 800 
Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser
                805                 810                 815     
Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp
            820                 825                 830         
Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile
        835                 840                 845             
Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met
    850                 855                 860                 
Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val
865                 870                 875                 880 
Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu
                885                 890                 895     
Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly
            900                 905                 910         
Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr
        915                 920                 925             
Gly Tyr Glu Asn Phe
    930             

<210>  2
<211>  2799
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  2
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttc                            2799


<210>  3
<211>  4104
<212>  DNA
<213>  Human

<220> 
<223> Full length IGF-IR

<400>  3
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttca tccatctgat catcgctctg     2820

cccgtcgctg tcctgttgat cgtgggaggg ttggtgatta tgctgtacgt cttccataga     2880

aagagaaata acagcaggct ggggaatgga gtgctgtatg cctctgtgaa cccggagtac     2940

ttcagcgctg ctgatgtgta cgttcctgat gagtgggagg tggctcggga gaagatcacc     3000

atgagccggg aacttgggca ggggtcgttt gggatggtct atgaaggagt tgccaagggt     3060

gtggtgaaag atgaacctga aaccagagtg gccattaaaa cagtgaacga ggccgcaagc     3120

atgcgtgaga ggattgagtt tctcaacgaa gcttctgtga tgaaggagtt caattgtcac     3180

catgtggtgc gattgctggg tgtggtgtcc caaggccagc caacactggt catcatggaa     3240

ctgatgacac ggggcgatct caaaagttat ctccggtctc tgaggccaga aatggagaat     3300

aatccagtcc tagcacctcc aagcctgagc aagatgattc agatggccgg agagattgca     3360

gacggcatgg catacctcaa cgccaataag ttcgtccaca gagaccttgc tgcccggaat     3420

tgcatggtag ccgaagattt cacagtcaaa atcggagatt ttggtatgac gcgagatatc     3480

tatgagacag actattaccg gaaaggaggg aaagggctgc tgcccgtgcg ctggatgtct     3540

cctgagtccc tcaaggatgg agtcttcacc acttactcgg acgtctggtc cttcggggtc     3600

gtcctctggg agatcgccac actggccgag cagccctacc agggcttgtc caacgagcaa     3660

gtccttcgct tcgtcatgga gggcggcctt ctggacaagc cagacaactg tcctgacatg     3720

ctgtttgaac tgatgcgcat gtgctggcag tataacccca agatgaggcc ttccttcctg     3780

gagatcatca gcagcatcaa agaggagatg gagcctggct tccgggaggt ctccttctac     3840

tacagcgagg agaacaagct gcccgagccg gaggagctgg acctggagcc agagaacatg     3900

gagagcgtcc ccctggaccc ctcggcctcc tcgtcctccc tgccactgcc cgacagacac     3960

tcaggacaca aggccgagaa cggccccggc cctggggtgc tggtcctccg cgccagcttc     4020

gacgagagac agccttacgc ccacatgaac gggggccgca agaacgagcg ggccttgccg     4080

ctgccccagt cttcgacctg ctga                                            4104


<210> 4
<211> 1367
<212> PRT
<213> Human

<220> 
<223> Full length IGF-IR

<400> 4
Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu
 1               5                  10                  15      
Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile
            20                  25                  30          
Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg
        35                  40                  45              
Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile
    50                  55                  60                  
Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val
65                  70                  75                  80  
Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu
                85                  90                  95      
Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe
            100                 105                 110         
Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile
        115                 120                 125             
Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu
    130                 135                 140                 
Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile
145                 150                 155                 160 
Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys
                165                 170                 175     
Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys
            180                 185                 190         
Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr
        195                 200                 205             
Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys
    210                 215                 220                 
Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser
225                 230                 235                 240 
Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr
                245                 250                 255     
Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu
            260                 265                 270         
Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala
        275                 280                 285             
Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met
    290                 295                 300                 
Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr
305                 310                 315                 320 
Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys
                325                 330                 335     
Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly
            340                 345                 350         
Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn
        355                 360                 365             
Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val
    370                 375                 380                 
Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser
385                 390                 395                 400 
Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly
                405                 410                 415     
Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp
            420                 425                 430         
Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe
        435                 440                 445             
Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu
    450                 455                 460                 
Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg
465                 470                 475                 480 
Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr
                485                 490                 495     
Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr
            500                 505                 510         
Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys
        515                 520                 525             
Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys
    530                 535                 540                 
Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys
545                 550                 555                 560 
Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln
                565                 570                 575     
Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp
            580                 585                 590         
His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala
        595                 600                 605             
Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser
    610                 615                 620                 
Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn
625                 630                 635                 640 
Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr
                645                 650                 655     
Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys
            660                 665                 670         
Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys
        675                 680                 685             
Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys
    690                 695                 700                 
Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys
705                 710                 715                 720 
Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu
                725                 730                 735     
Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser
            740                 745                 750         
Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro
        755                 760                 765             
Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn
    770                 775                 780                 
Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg
785                 790                 795                 800 
Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser
                805                 810                 815     
Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp
            820                 825                 830         
Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile
        835                 840                 845             
Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met
    850                 855                 860                 
Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val
865                 870                 875                 880 
Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu
                885                 890                 895     
Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly
            900                 905                 910         
Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr
        915                 920                 925             
Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val
    930                 935                 940                 
Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg
945                 950                 955                 960 
Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val
                965                 970                 975     
Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp
            980                 985                 990         
Glu Val Ala Arg Glu Lys Ile Thr Met Ser Arg Glu Leu Gly Gln Gly
        995                 1000                1005            
Ser Phe Gly Met Val Tyr Glu Gly Val Ala Lys Gly Val Val Lys Asp
    1010                1015                1020                
Glu Pro Glu Thr Arg Val Ala Ile Lys Thr Val Asn Glu Ala Ala Ser
1025                1030                1035                1040
Met Arg Glu Arg Ile Glu Phe Leu Asn Glu Ala Ser Val Met Lys Glu
                1045                1050                1055    
Phe Asn Cys His His Val Val Arg Leu Leu Gly Val Val Ser Gln Gly
            1060                1065                1070        
Gln Pro Thr Leu Val Ile Met Glu Leu Met Thr Arg Gly Asp Leu Lys
        1075                1080                1085            
Ser Tyr Leu Arg Ser Leu Arg Pro Glu Met Glu Asn Asn Pro Val Leu
    1090                1095                1100                
Ala Pro Pro Ser Leu Ser Lys Met Ile Gln Met Ala Gly Glu Ile Ala
1105                1110                1115                1120
Asp Gly Met Ala Tyr Leu Asn Ala Asn Lys Phe Val His Arg Asp Leu
                1125                1130                1135    
Ala Ala Arg Asn Cys Met Val Ala Glu Asp Phe Thr Val Lys Ile Gly
            1140                1145                1150        
Asp Phe Gly Met Thr Arg Asp Ile Tyr Glu Thr Asp Tyr Tyr Arg Lys
        1155                1160                1165            
Gly Gly Lys Gly Leu Leu Pro Val Arg Trp Met Ser Pro Glu Ser Leu
    1170                1175                1180                
Lys Asp Gly Val Phe Thr Thr Tyr Ser Asp Val Trp Ser Phe Gly Val
1185                1190                1195                1200
Val Leu Trp Glu Ile Ala Thr Leu Ala Glu Gln Pro Tyr Gln Gly Leu
                1205                1210                1215    
Ser Asn Glu Gln Val Leu Arg Phe Val Met Glu Gly Gly Leu Leu Asp
            1220                1225                1230        
Lys Pro Asp Asn Cys Pro Asp Met Leu Phe Glu Leu Met Arg Met Cys
        1235                1240                1245            
Trp Gln Tyr Asn Pro Lys Met Arg Pro Ser Phe Leu Glu Ile Ile Ser
    1250                1255                1260                
Ser Ile Lys Glu Glu Met Glu Pro Gly Phe Arg Glu Val Ser Phe Tyr
1265                1270                1275                1280
Tyr Ser Glu Glu Asn Lys Leu Pro Glu Pro Glu Glu Leu Asp Leu Glu
                1285                1290                1295    
Pro Glu Asn Met Glu Ser Val Pro Leu Asp Pro Ser Ala Ser Ser Ser
            1300                1305                1310        
Ser Leu Pro Leu Pro Asp Arg His Ser Gly His Lys Ala Glu Asn Gly
        1315                1320                1325            
Pro Gly Pro Gly Val Leu Val Leu Arg Ala Ser Phe Asp Glu Arg Gln
    1330                1335                1340                
Pro Tyr Ala His Met Asn Gly Gly Arg Lys Asn Glu Arg Ala Leu Pro
1345                1350                1355                1360
Leu Pro Gln Ser Ser Thr Cys
                1365        

<210>  5
<211>  2802
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IGF1R from ATG to STOP

<400>  5
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttct ga                        2802


<210>  6
<211>  933
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IGF1R

<400>  6

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe 
    930             


<210>  7
<211>  3516
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sIGF1R-hFc-IgG1

<400>  7
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttcg aattcgatat ctcgagcacc     2820

atggttagat ctgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     2880

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     2940

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     3000

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     3060

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     3120

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     3180

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     3240

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     3300

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     3360

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     3420

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcacg aggctctgca caaccactac     3480

acgcagaaga gcctctccct gtctccgggt aaatga                               3516

<210>  8
<211>  1171
<212>  PRT
<213>  Artificial sequence

<220>
<223>  sIGF1R-hFc-IgG1

<400>  8

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Glu Phe Asp Ile Ser Ser Thr Met Val Arg Ser 
    930                 935                 940                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
945                 950                 955                 960 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                965                 970                 975     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            980                 985                 990         


Glu Asp Pro Glu Val Lys Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val 
        995                 1000                 1005             


His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu Gln Tyr  Asn Ser Thr 
    1010                 1015                 1020             


Tyr Arg  Val Val Ser Val Leu  Thr Val Leu His Gln  Asp Trp Leu 
    1025                 1030                 1035             


Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser Asn Lys  Ala Leu Pro 
    1040                 1045                 1050             


Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg 
    1055                 1060                 1065             


Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser Arg Glu  Glu Met Thr 
    1070                 1075                 1080             


Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro 
    1085                 1090                 1095             


Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn 
    1100                 1105                 1110             


Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe 
    1115                 1120                 1125             


Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln 
    1130                 1135                 1140             


Gly Asn  Val Phe Ser Cys Ser  Val Met His Glu Ala  Leu His Asn 
    1145                 1150                 1155             


His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser Pro Gly  Lys 
    1160                 1165                 1170     


<210>  9
<211>  3486
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sIGF1R-hFc-IgG2

<400>  9
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttcg agcgcaaatg ttgtgtcgag     2820

tgcccaccgt gcccagcacc acctgtggca ggaccgtcag tcttcctctt ccccccaaaa     2880

cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg     2940

agccacgaag accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcataat     3000

gccaagacaa agccacggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc     3060

accgttgtgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa     3120

ggcctcccag cccccatcga gaaaaccatc tccaaaacca aagggcagcc ccgagaacca     3180

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     3240

tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag     3300

ccggagaaca actacaagac cacacctccc atgctggact ccgacggctc cttcttcctc     3360

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     3420

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     3480

aaatga                                                                3486


<210>  10
<211>  1161
<212>  PRT
<213>  Artificial sequence

<220>
<223>  sIGF1R-hFc-IgG2

<400>  10

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    930                 935                 940                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
945                 950                 955                 960 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                965                 970                 975     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            980                 985                 990         


Val Asp Gly Val Glu Val His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu 
        995                 1000                 1005             


Gln Phe  Asn Ser Thr Phe Arg  Val Val Ser Val Leu  Thr Val Val 
    1010                 1015                 1020             


His Gln  Asp Trp Leu Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser 
    1025                 1030                 1035             


Asn Lys  Gly Leu Pro Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Thr 
    1040                 1045                 1050             


Lys Gly  Gln Pro Arg Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser 
    1055                 1060                 1065             


Arg Glu  Glu Met Thr Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val 
    1070                 1075                 1080             


Lys Gly  Phe Tyr Pro Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn 
    1085                 1090                 1095             


Gly Gln  Pro Glu Asn Asn Tyr  Lys Thr Thr Pro Pro  Met Leu Asp 
    1100                 1105                 1110             


Ser Asp  Gly Ser Phe Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys 
    1115                 1120                 1125             


Ser Arg  Trp Gln Gln Gly Asn  Val Phe Ser Cys Ser  Val Met His 
    1130                 1135                 1140             


Glu Ala  Leu His Asn His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser 
    1145                 1150                 1155             


Pro Gly  Lys 
    1160     


<210>  11
<211>  3516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mod#1

<400>  11
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttcg aattcgatat ctcgagcacc     2820

atggttagat ctgacaaaac tcacacaagc ccaccgagtc cagcacctga actcctgggg     2880

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     2940

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     3000

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     3060

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     3120

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     3180

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     3240

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     3300

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     3360

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     3420

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcacg aggctctgca caaccactac     3480

acgcagaaga gcctctccct gtctccgggt aaatga                               3516


<210>  12
<211>  1171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mod#1

<400>  12

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Glu Phe Asp Ile Ser Ser Thr Met Val Arg Ser 
    930                 935                 940                 


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
945                 950                 955                 960 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                965                 970                 975     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            980                 985                 990         


Glu Asp Pro Glu Val Lys Phe Asn  Trp Tyr Val Asp Gly  Val Glu Val 
        995                 1000                 1005             


His Asn  Ala Lys Thr Lys Pro  Arg Glu Glu Gln Tyr  Asn Ser Thr 
    1010                 1015                 1020             


Tyr Arg  Val Val Ser Val Leu  Thr Val Leu His Gln  Asp Trp Leu 
    1025                 1030                 1035             


Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser Asn Lys  Ala Leu Pro 
    1040                 1045                 1050             


Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala Lys Gly  Gln Pro Arg 
    1055                 1060                 1065             


Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser Arg Glu  Glu Met Thr 
    1070                 1075                 1080             


Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val Lys Gly  Phe Tyr Pro 
    1085                 1090                 1095             


Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn 
    1100                 1105                 1110             


Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe 
    1115                 1120                 1125             


Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln 
    1130                 1135                 1140             


Gly Asn  Val Phe Ser Cys Ser  Val Met His Glu Ala  Leu His Asn 
    1145                 1150                 1155             


His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser Pro Gly  Lys 
    1160                 1165                 1170     


<210>  13
<211>  3549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mod#2

<400>  13
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttcg gcggcggcgg tagtggcggc     2820

ggtggcagcg gcggtggcgg cagtggtggc ggcggcagcg gtggcgacaa aactcacaca     2880

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     2940

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     3000

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     3060

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     3120

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     3180

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     3240

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     3300

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     3360

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     3420

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     3480

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     3540

ggtaaatga                                                             3549


<210>  14
<211>  1182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mod#2

<400>  14

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Lys Thr His Thr 
945                 950                 955                 960 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                965                 970                 975     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            980                 985                 990         


Glu Val Thr Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
        995                 1000                 1005             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1010                 1015                 1020             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1025                 1030                 1035             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1040                 1045                 1050             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1055                 1060                 1065             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1070                 1075                 1080             


Tyr Thr  Leu Pro Pro Ser Arg  Glu Glu Met Thr Lys  Asn Gln Val 
    1085                 1090                 1095             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1100                 1105                 1110             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1115                 1120                 1125             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1130                 1135                 1140             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1145                 1150                 1155             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1160                 1165                 1170             


Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1175                 1180         


<210>  15
<211>  3549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mod#3

<400>  15
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttcg gcggcggcgg tagtggcggc     2820

ggtggcagcg gcggtggcgg cagtggtggc ggcggcagcg gtggcgacaa aactcacaca     2880

agcccaccga gtccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     2940

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     3000

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     3060

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     3120

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     3180

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     3240

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg     3300

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     3360

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     3420

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     3480

tccgtgatgc acgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     3540

ggtaaatga                                                             3549


<210>  16
<211>  1182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mod#3

<400>  16

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Lys Thr His Thr 
945                 950                 955                 960 


Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                965                 970                 975     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            980                 985                 990         


Glu Val Thr Cys Val Val Val Asp  Val Ser His Glu Asp  Pro Glu Val 
        995                 1000                 1005             


Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu Val His  Asn Ala Lys 
    1010                 1015                 1020             


Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser Thr Tyr  Arg Val Val 
    1025                 1030                 1035             


Ser Val  Leu Thr Val Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu 
    1040                 1045                 1050             


Tyr Lys  Cys Lys Val Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu 
    1055                 1060                 1065             


Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val 
    1070                 1075                 1080             


Tyr Thr  Leu Pro Pro Ser Arg  Glu Glu Met Thr Lys  Asn Gln Val 
    1085                 1090                 1095             


Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
    1100                 1105                 1110             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1115                 1120                 1125             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1130                 1135                 1140             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1145                 1150                 1155             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1160                 1165                 1170             


Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1175                 1180         


<210>  17
<211>  3540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mod#4

<400>  17
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttcg gcggcggcgg tagtggcggc     2820

ggtggcagcg gcggtggcgg cagtggtggc ggcggcagcg gcggcggcgg tagtggtggc     2880

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag     2940

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     3000

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     3060

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     3120

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     3180

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     3240

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     3300

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     3360

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     3420

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     3480

cacgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatga     3540


<210>  18
<211>  1179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mod#4

<400>  18

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    930                 935                 940                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
945                 950                 955                 960 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                965                 970                 975     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            980                 985                 990         


Cys Val Val Val Asp Val Ser His  Glu Asp Pro Glu Val  Lys Phe Asn 
        995                 1000                 1005             


Trp Tyr  Val Asp Gly Val Glu  Val His Asn Ala Lys  Thr Lys Pro 
    1010                 1015                 1020             


Arg Glu  Glu Gln Tyr Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu 
    1025                 1030                 1035             


Thr Val  Leu His Gln Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys 
    1040                 1045                 1050             


Lys Val  Ser Asn Lys Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile 
    1055                 1060                 1065             


Ser Lys  Ala Lys Gly Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu 
    1070                 1075                 1080             


Pro Pro  Ser Arg Glu Glu Met  Thr Lys Asn Gln Val  Ser Leu Thr 
    1085                 1090                 1095             


Cys Leu  Val Lys Gly Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp 
    1100                 1105                 1110             


Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 
    1115                 1120                 1125             


Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 
    1130                 1135                 1140             


Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 
    1145                 1150                 1155             


Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 
    1160                 1165                 1170             


Ser Leu  Ser Pro Gly Lys 
    1175                 




