                         SEQUENCE LISTING

<110>  Oslo universitetssykehus HF
       Robertson, Adam B.
       Dahl, John A.
       Klungland, Arne
       Ellevag, Linda
 
<120>  Methods and Kits for Detection of Methylation Status

<130>  INVEN-32320/WO-1/ORD

<150>  US 61/570,066
<151>  2011-12-13

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1627
<212>  PRT
<213>  Mus musculus

<400>  1

Met Pro Ala Arg Thr Ala Pro Ala Arg Val Pro Ala Leu Ala Ser Pro 
1               5                   10                  15      


Ala Gly Ser Leu Pro Asp His Val Arg Arg Arg Leu Lys Asp Leu Glu 
            20                  25                  30          


Arg Asp Gly Leu Thr Glu Lys Glu Cys Val Arg Glu Lys Leu Asn Leu 
        35                  40                  45              


Leu His Glu Phe Leu Gln Thr Glu Ile Lys Ser Gln Leu Cys Asp Leu 
    50                  55                  60                  


Glu Thr Lys Leu His Lys Glu Glu Leu Ser Glu Glu Gly Tyr Leu Ala 
65                  70                  75                  80  


Lys Val Lys Ser Leu Leu Asn Lys Asp Leu Ser Leu Glu Asn Gly Thr 
                85                  90                  95      


His Thr Leu Thr Gln Lys Ala Asn Gly Cys Pro Ala Asn Gly Ser Arg 
            100                 105                 110         


Pro Thr Trp Arg Ala Glu Met Ala Asp Ser Asn Arg Ser Pro Arg Ser 
        115                 120                 125             


Arg Pro Lys Pro Arg Gly Pro Arg Arg Ser Lys Ser Asp Ser Asp Thr 
    130                 135                 140                 


Leu Cys Lys Asp Thr Arg His Thr Ala Val Glu Thr Ser Pro Ser Ser 
145                 150                 155                 160 


Val Ala Thr Arg Arg Thr Thr Arg Gln Thr Thr Ile Thr Ala His Phe 
                165                 170                 175     


Thr Lys Gly Pro Thr Lys Arg Lys Pro Lys Glu Glu Ser Glu Glu Gly 
            180                 185                 190         


Asn Ser Ala Glu Ser Ala Ala Glu Glu Arg Asp Gln Asp Lys Lys Arg 
        195                 200                 205             


Arg Val Val Asp Thr Glu Ser Gly Ala Ala Ala Ala Val Glu Lys Leu 
    210                 215                 220                 


Glu Glu Val Thr Ala Gly Thr Gln Leu Gly Pro Glu Glu Pro Cys Glu 
225                 230                 235                 240 


Gln Glu Asp Asp Asn Arg Ser Leu Arg Arg His Thr Arg Glu Leu Ser 
                245                 250                 255     


Leu Arg Arg Lys Ser Lys Glu Asp Pro Asp Arg Glu Ala Arg Pro Glu 
            260                 265                 270         


Thr His Leu Asp Glu Asp Glu Asp Gly Lys Lys Asp Lys Arg Ser Ser 
        275                 280                 285             


Arg Pro Arg Ser Gln Pro Arg Asp Pro Ala Ala Lys Arg Arg Pro Lys 
    290                 295                 300                 


Glu Ala Glu Pro Glu Gln Val Ala Pro Glu Thr Pro Glu Asp Arg Asp 
305                 310                 315                 320 


Glu Asp Glu Arg Glu Glu Lys Arg Arg Lys Thr Thr Arg Lys Lys Leu 
                325                 330                 335     


Glu Ser His Thr Val Pro Val Gln Ser Arg Ser Glu Arg Lys Ala Ala 
            340                 345                 350         


Gln Ser Lys Ser Val Ile Pro Lys Ile Asn Ser Pro Lys Cys Pro Glu 
        355                 360                 365             


Cys Gly Gln His Leu Asp Asp Pro Asn Leu Lys Tyr Gln Gln His Pro 
    370                 375                 380                 


Glu Asp Ala Val Asp Glu Pro Gln Met Leu Thr Ser Glu Lys Leu Ser 
385                 390                 395                 400 


Ile Tyr Asp Ser Thr Ser Thr Trp Phe Asp Thr Tyr Glu Asp Ser Pro 
                405                 410                 415     


Met His Arg Phe Thr Ser Phe Ser Val Tyr Cys Ser Arg Gly His Leu 
            420                 425                 430         


Cys Pro Val Asp Thr Gly Leu Ile Glu Lys Asn Val Glu Leu Tyr Phe 
        435                 440                 445             


Ser Gly Cys Ala Lys Ala Ile His Asp Glu Asn Pro Ser Met Glu Gly 
    450                 455                 460                 


Gly Ile Asn Gly Lys Asn Leu Gly Pro Ile Asn Gln Trp Trp Leu Ser 
465                 470                 475                 480 


Gly Phe Asp Gly Gly Glu Lys Val Leu Ile Gly Phe Ser Thr Ala Phe 
                485                 490                 495     


Ala Glu Tyr Ile Leu Met Glu Pro Ser Lys Glu Tyr Glu Pro Ile Phe 
            500                 505                 510         


Gly Leu Met Gln Glu Lys Ile Tyr Ile Ser Lys Ile Val Val Glu Phe 
        515                 520                 525             


Leu Gln Asn Asn Pro Asp Ala Val Tyr Glu Asp Leu Ile Asn Lys Ile 
    530                 535                 540                 


Glu Thr Thr Val Pro Pro Ser Thr Ile Asn Val Asn Arg Phe Thr Glu 
545                 550                 555                 560 


Asp Ser Leu Leu Arg His Ala Gln Phe Val Val Ser Gln Val Glu Ser 
                565                 570                 575     


Tyr Asp Glu Ala Lys Asp Asp Asp Glu Thr Pro Ile Phe Leu Ser Pro 
            580                 585                 590         


Cys Met Arg Ala Leu Ile His Leu Ala Gly Val Ser Leu Gly Gln Arg 
        595                 600                 605             


Arg Ala Thr Arg Arg Val Met Gly Ala Thr Lys Glu Lys Asp Lys Ala 
    610                 615                 620                 


Pro Thr Lys Ala Thr Thr Thr Lys Leu Val Tyr Gln Ile Phe Asp Thr 
625                 630                 635                 640 


Phe Phe Ser Glu Gln Ile Glu Lys Tyr Asp Lys Glu Asp Lys Glu Asn 
                645                 650                 655     


Ala Met Lys Arg Arg Arg Cys Gly Val Cys Glu Val Cys Gln Gln Pro 
            660                 665                 670         


Glu Cys Gly Lys Cys Lys Ala Cys Lys Asp Met Val Lys Phe Gly Gly 
        675                 680                 685             


Thr Gly Arg Ser Lys Gln Ala Cys Leu Lys Arg Arg Cys Pro Asn Leu 
    690                 695                 700                 


Ala Val Lys Glu Ala Asp Asp Asp Glu Glu Ala Asp Asp Asp Val Ser 
705                 710                 715                 720 


Glu Met Pro Ser Pro Lys Lys Leu His Gln Gly Lys Lys Lys Lys Gln 
                725                 730                 735     


Asn Lys Asp Arg Ile Ser Trp Leu Gly Gln Pro Met Lys Ile Glu Glu 
            740                 745                 750         


Asn Arg Thr Tyr Tyr Gln Lys Val Ser Ile Asp Glu Glu Met Leu Glu 
        755                 760                 765             


Val Gly Asp Cys Val Ser Val Ile Pro Asp Asp Ser Ser Lys Pro Leu 
    770                 775                 780                 


Tyr Leu Ala Arg Val Thr Ala Leu Trp Glu Asp Lys Asn Gly Gln Met 
785                 790                 795                 800 


Met Phe His Ala His Trp Phe Cys Ala Gly Thr Asp Thr Val Leu Gly 
                805                 810                 815     


Ala Thr Ser Asp Pro Leu Glu Leu Phe Leu Val Gly Glu Cys Glu Asn 
            820                 825                 830         


Met Gln Leu Ser Tyr Ile His Ser Lys Val Lys Val Ile Tyr Lys Ala 
        835                 840                 845             


Pro Ser Glu Asn Trp Ala Met Glu Gly Gly Thr Asp Pro Glu Thr Thr 
    850                 855                 860                 


Leu Pro Gly Ala Glu Asp Gly Lys Thr Tyr Phe Phe Gln Leu Trp Tyr 
865                 870                 875                 880 


Asn Gln Glu Tyr Ala Arg Phe Glu Ser Pro Pro Lys Thr Gln Pro Thr 
                885                 890                 895     


Glu Asp Asn Lys His Lys Phe Cys Leu Ser Cys Ile Arg Leu Ala Glu 
            900                 905                 910         


Leu Arg Gln Lys Glu Met Pro Lys Val Leu Glu Gln Ile Glu Glu Val 
        915                 920                 925             


Asp Gly Arg Val Tyr Cys Ser Ser Ile Thr Lys Asn Gly Val Val Tyr 
    930                 935                 940                 


Arg Leu Gly Asp Ser Val Tyr Leu Pro Pro Glu Ala Phe Thr Phe Asn 
945                 950                 955                 960 


Ile Lys Val Ala Ser Pro Val Lys Arg Pro Lys Lys Asp Pro Val Asn 
                965                 970                 975     


Glu Thr Leu Tyr Pro Glu His Tyr Arg Lys Tyr Ser Asp Tyr Ile Lys 
            980                 985                 990         


Gly Ser Asn Leu Asp Ala Pro Glu  Pro Tyr Arg Ile Gly  Arg Ile Lys 
        995                 1000                 1005             


Glu Ile  His Cys Gly Lys Lys  Lys Gly Lys Val Asn  Glu Ala Asp 
    1010                 1015                 1020             


Ile Lys  Leu Arg Leu Tyr Lys  Phe Tyr Arg Pro Glu  Asn Thr His 
    1025                 1030                 1035             


Arg Ser  Tyr Asn Gly Ser Tyr  His Thr Asp Ile Asn  Met Leu Tyr 
    1040                 1045                 1050             


Trp Ser  Asp Glu Glu Ala Val  Val Asn Phe Ser Asp  Val Gln Gly 
    1055                 1060                 1065             


Arg Cys  Thr Val Glu Tyr Gly  Glu Asp Leu Leu Glu  Ser Ile Gln 
    1070                 1075                 1080             


Asp Tyr  Ser Gln Gly Gly Pro  Asp Arg Phe Tyr Phe  Leu Glu Ala 
    1085                 1090                 1095             


Tyr Asn  Ser Lys Thr Lys Asn  Phe Glu Asp Pro Pro  Asn His Ala 
    1100                 1105                 1110             


Arg Ser  Pro Gly Asn Lys Gly  Lys Gly Lys Gly Lys  Gly Lys Gly 
    1115                 1120                 1125             


Lys Gly  Lys His Gln Val Ser  Glu Pro Lys Glu Pro  Glu Ala Ala 
    1130                 1135                 1140             


Ile Lys  Leu Pro Lys Leu Arg  Thr Leu Asp Val Phe  Ser Gly Cys 
    1145                 1150                 1155             


Gly Gly  Leu Ser Glu Gly Phe  His Gln Ala Gly Ile  Ser Glu Thr 
    1160                 1165                 1170             


Leu Trp  Ala Ile Glu Met Trp  Asp Pro Ala Ala Gln  Ala Phe Arg 
    1175                 1180                 1185             


Leu Asn  Asn Pro Gly Thr Thr  Val Phe Thr Glu Asp  Cys Asn Val 
    1190                 1195                 1200             


Leu Leu  Lys Leu Val Met Ala  Gly Glu Val Thr Asn  Ser Leu Gly 
    1205                 1210                 1215             


Gln Arg  Leu Pro Gln Lys Gly  Asp Val Glu Met Leu  Cys Gly Gly 
    1220                 1225                 1230             


Pro Pro  Cys Gln Gly Phe Ser  Gly Met Asn Arg Phe  Asn Ser Arg 
    1235                 1240                 1245             


Thr Tyr  Ser Lys Phe Lys Asn  Ser Leu Val Val Ser  Phe Leu Ser 
    1250                 1255                 1260             


Tyr Cys  Asp Tyr Tyr Arg Pro  Arg Phe Phe Leu Leu  Glu Asn Val 
    1265                 1270                 1275             


Arg Asn  Phe Val Ser Tyr Arg  Arg Ser Met Val Leu  Lys Leu Thr 
    1280                 1285                 1290             


Leu Arg  Cys Leu Val Arg Met  Gly Tyr Gln Cys Thr  Phe Gly Val 
    1295                 1300                 1305             


Leu Gln  Ala Gly Gln Tyr Gly  Val Ala Gln Thr Arg  Arg Arg Ala 
    1310                 1315                 1320             


Ile Ile  Leu Ala Ala Ala Pro  Gly Glu Lys Leu Pro  Leu Phe Pro 
    1325                 1330                 1335             


Glu Pro  Leu His Val Phe Ala  Pro Arg Ala Cys Gln  Leu Ser Val 
    1340                 1345                 1350             


Val Val  Asp Asp Lys Lys Phe  Val Ser Asn Ile Thr  Arg Leu Ser 
    1355                 1360                 1365             


Ser Gly  Pro Phe Arg Thr Ile  Thr Val Arg Asp Thr  Met Ser Asp 
    1370                 1375                 1380             


Leu Pro  Glu Ile Gln Asn Gly  Ala Ser Asn Ser Glu  Ile Pro Tyr 
    1385                 1390                 1395             


Asn Gly  Glu Pro Leu Ser Trp  Phe Gln Arg Gln Leu  Arg Gly Ser 
    1400                 1405                 1410             


His Tyr  Gln Pro Ile Leu Arg  Asp His Ile Cys Lys  Asp Met Ser 
    1415                 1420                 1425             


Pro Leu  Val Ala Ala Arg Met  Arg His Ile Pro Leu  Phe Pro Gly 
    1430                 1435                 1440             


Ser Asp  Trp Arg Asp Leu Pro  Asn Ile Gln Val Arg  Leu Gly Asp 
    1445                 1450                 1455             


Gly Val  Ile Ala His Lys Leu  Gln Tyr Thr Phe His  Asp Val Lys 
    1460                 1465                 1470             


Asn Gly  Tyr Ser Ser Thr Gly  Ala Leu Arg Gly Val  Cys Ser Cys 
    1475                 1480                 1485             


Ala Glu  Gly Lys Ala Cys Asp  Pro Glu Ser Arg Gln  Phe Ser Thr 
    1490                 1495                 1500             


Leu Ile  Pro Trp Cys Leu Pro  His Thr Gly Asn Arg  His Asn His 
    1505                 1510                 1515             


Trp Ala  Gly Leu Tyr Gly Arg  Leu Glu Trp Asp Gly  Phe Phe Ser 
    1520                 1525                 1530             


Thr Thr  Val Thr Asn Pro Glu  Pro Met Gly Lys Gln  Gly Arg Val 
    1535                 1540                 1545             


Leu His  Pro Glu Gln His Arg  Val Val Ser Val Arg  Glu Cys Ala 
    1550                 1555                 1560             


Arg Ser  Gln Gly Phe Pro Asp  Ser Tyr Arg Phe Phe  Gly Asn Ile 
    1565                 1570                 1575             


Leu Asp  Arg His Arg Gln Val  Gly Asn Ala Val Pro  Pro Pro Leu 
    1580                 1585                 1590             


Ala Lys  Ala Ile Gly Leu Glu  Ile Lys Leu Cys Leu  Leu Ser Ser 
    1595                 1600                 1605             


Ala Arg  Glu Ser Ala Ser Ala  Ala Val Lys Ala Lys  Glu Glu Ala 
    1610                 1615                 1620             


Ala Thr  Lys Asp 
    1625         


<210>  2
<211>  1632
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ala Arg Thr Ala Pro Ala Arg Val Pro Thr Leu Ala Val Pro 
1               5                   10                  15      


Ala Ile Ser Leu Pro Asp Asp Val Arg Arg Arg Leu Lys Asp Leu Glu 
            20                  25                  30          


Arg Asp Ser Leu Thr Glu Lys Glu Cys Val Lys Glu Lys Leu Asn Leu 
        35                  40                  45              


Leu His Glu Phe Leu Gln Thr Glu Ile Lys Asn Gln Leu Cys Asp Leu 
    50                  55                  60                  


Glu Thr Lys Leu Arg Lys Glu Glu Leu Ser Glu Glu Gly Tyr Leu Ala 
65                  70                  75                  80  


Lys Val Lys Ser Leu Leu Asn Lys Asp Leu Ser Leu Glu Asn Gly Ala 
                85                  90                  95      


His Ala Tyr Asn Arg Glu Val Asn Gly Arg Leu Glu Asn Gly Asn Gln 
            100                 105                 110         


Ala Arg Ser Glu Ala Arg Arg Val Gly Met Ala Asp Ala Asn Ser Pro 
        115                 120                 125             


Pro Lys Pro Leu Ser Lys Pro Arg Thr Pro Arg Arg Ser Lys Ser Asp 
    130                 135                 140                 


Gly Glu Ala Lys Arg Ser Arg Asp Pro Pro Ala Ser Ala Ser Gln Val 
145                 150                 155                 160 


Thr Gly Ile Arg Ala Glu Pro Ser Pro Ser Pro Arg Ile Thr Arg Lys 
                165                 170                 175     


Ser Thr Arg Gln Thr Thr Ile Thr Ser His Phe Ala Lys Gly Pro Ala 
            180                 185                 190         


Lys Arg Lys Pro Gln Glu Glu Ser Glu Arg Ala Lys Ser Asp Glu Ser 
        195                 200                 205             


Ile Lys Glu Glu Asp Lys Asp Gln Asp Glu Lys Arg Arg Arg Val Thr 
    210                 215                 220                 


Ser Arg Glu Arg Val Ala Arg Pro Leu Pro Ala Glu Glu Pro Glu Arg 
225                 230                 235                 240 


Ala Lys Ser Gly Thr Arg Thr Glu Lys Glu Glu Glu Arg Asp Glu Lys 
                245                 250                 255     


Glu Glu Lys Arg Leu Arg Ser Gln Thr Lys Glu Pro Thr Pro Lys Gln 
            260                 265                 270         


Lys Leu Lys Glu Glu Pro Asp Arg Glu Ala Arg Ala Gly Val Gln Ala 
        275                 280                 285             


Asp Glu Asp Glu Asp Gly Asp Glu Lys Asp Glu Lys Lys His Arg Ser 
    290                 295                 300                 


Gln Pro Lys Asp Leu Ala Ala Lys Arg Arg Pro Glu Glu Lys Glu Pro 
305                 310                 315                 320 


Glu Lys Val Asn Pro Gln Ile Ser Asp Glu Lys Asp Glu Asp Glu Lys 
                325                 330                 335     


Glu Glu Lys Arg Arg Lys Thr Thr Pro Lys Glu Pro Thr Glu Lys Lys 
            340                 345                 350         


Met Ala Arg Ala Lys Thr Val Met Asn Ser Lys Thr His Pro Pro Lys 
        355                 360                 365             


Cys Ile Gln Cys Gly Gln Tyr Leu Asp Asp Pro Asp Leu Lys Tyr Gly 
    370                 375                 380                 


Gln His Pro Pro Asp Ala Val Asp Glu Pro Gln Met Leu Thr Asn Glu 
385                 390                 395                 400 


Lys Leu Ser Ile Phe Asp Ala Asn Glu Ser Gly Phe Glu Ser Tyr Glu 
                405                 410                 415     


Ala Leu Pro Gln His Lys Leu Thr Cys Phe Ser Val Tyr Cys Lys His 
            420                 425                 430         


Gly His Leu Cys Pro Ile Asp Thr Gly Leu Ile Glu Lys Asn Ile Glu 
        435                 440                 445             


Leu Phe Phe Ser Gly Ser Ala Lys Pro Ile Tyr Asp Asp Asp Pro Ser 
    450                 455                 460                 


Leu Glu Gly Gly Val Asn Gly Lys Asn Leu Gly Pro Ile Asn Glu Trp 
465                 470                 475                 480 


Trp Ile Thr Gly Phe Asp Gly Gly Glu Lys Ala Leu Ile Gly Phe Ser 
                485                 490                 495     


Thr Ser Phe Ala Glu Tyr Ile Leu Met Asp Pro Ser Pro Glu Tyr Ala 
            500                 505                 510         


Pro Ile Phe Gly Leu Met Gln Glu Lys Ile Tyr Ile Ser Lys Ile Val 
        515                 520                 525             


Val Glu Phe Leu Gln Ser Asn Ser Asp Ser Thr Tyr Glu Asp Leu Ile 
    530                 535                 540                 


Asn Lys Ile Glu Thr Thr Val Pro Pro Ser Gly Leu Asn Leu Asn Arg 
545                 550                 555                 560 


Phe Thr Glu Asp Ser Leu Leu Arg His Ala Gln Phe Val Val Glu Gln 
                565                 570                 575     


Val Glu Ser Tyr Asp Glu Ala Gly Asp Ser Asp Glu Gln Pro Ile Phe 
            580                 585                 590         


Leu Thr Pro Cys Met Arg Asp Leu Ile Lys Leu Ala Gly Val Thr Leu 
        595                 600                 605             


Gly Gln Arg Arg Ala Gln Ala Arg Arg Gln Thr Ile Arg His Ser Thr 
    610                 615                 620                 


Arg Glu Lys Asp Arg Gly Pro Thr Lys Ala Thr Thr Thr Lys Leu Val 
625                 630                 635                 640 


Tyr Gln Ile Phe Asp Thr Phe Phe Ala Glu Gln Ile Glu Lys Asp Asp 
                645                 650                 655     


Arg Glu Asp Lys Glu Asn Ala Phe Lys Arg Arg Arg Cys Gly Val Cys 
            660                 665                 670         


Glu Val Cys Gln Gln Pro Glu Cys Gly Lys Cys Lys Ala Cys Lys Asp 
        675                 680                 685             


Met Val Lys Phe Gly Gly Ser Gly Arg Ser Lys Gln Ala Cys Gln Glu 
    690                 695                 700                 


Arg Arg Cys Pro Asn Met Ala Met Lys Glu Ala Asp Asp Asp Glu Glu 
705                 710                 715                 720 


Val Asp Asp Asn Ile Pro Glu Met Pro Ser Pro Lys Lys Met His Gln 
                725                 730                 735     


Gly Lys Lys Lys Lys Gln Asn Lys Asn Arg Ile Ser Trp Val Gly Glu 
            740                 745                 750         


Ala Val Lys Thr Asp Gly Lys Lys Ser Tyr Tyr Lys Lys Val Cys Ile 
        755                 760                 765             


Asp Ala Glu Thr Leu Glu Val Gly Asp Cys Val Ser Val Ile Pro Asp 
    770                 775                 780                 


Asp Ser Ser Lys Pro Leu Tyr Leu Ala Arg Val Thr Ala Leu Trp Glu 
785                 790                 795                 800 


Asp Ser Ser Asn Gly Gln Met Phe His Ala His Trp Phe Cys Ala Gly 
                805                 810                 815     


Thr Asp Thr Val Leu Gly Ala Thr Ser Asp Pro Leu Glu Leu Phe Leu 
            820                 825                 830         


Val Asp Glu Cys Glu Asp Met Gln Leu Ser Tyr Ile His Ser Lys Val 
        835                 840                 845             


Lys Val Ile Tyr Lys Ala Pro Ser Glu Asn Trp Ala Met Glu Gly Gly 
    850                 855                 860                 


Met Asp Pro Glu Ser Leu Leu Glu Gly Asp Asp Gly Lys Thr Tyr Phe 
865                 870                 875                 880 


Tyr Gln Leu Trp Tyr Asp Gln Asp Tyr Ala Arg Phe Glu Ser Pro Pro 
                885                 890                 895     


Lys Thr Gln Pro Thr Glu Asp Asn Lys Phe Lys Phe Cys Val Ser Cys 
            900                 905                 910         


Ala Arg Leu Ala Glu Met Arg Gln Lys Glu Ile Pro Arg Val Leu Glu 
        915                 920                 925             


Gln Leu Glu Asp Leu Asp Ser Arg Val Leu Tyr Tyr Ser Ala Thr Lys 
    930                 935                 940                 


Asn Gly Ile Leu Tyr Arg Val Gly Asp Gly Val Tyr Leu Pro Pro Glu 
945                 950                 955                 960 


Ala Phe Thr Phe Asn Ile Lys Leu Ser Ser Pro Val Lys Arg Pro Arg 
                965                 970                 975     


Lys Glu Pro Val Asp Glu Asp Leu Tyr Pro Glu His Tyr Arg Lys Tyr 
            980                 985                 990         


Ser Asp Tyr Ile Lys Gly Ser Asn  Leu Asp Ala Pro Glu  Pro Tyr Arg 
        995                 1000                 1005             


Ile Gly  Arg Ile Lys Glu Ile  Phe Cys Pro Lys Lys  Ser Asn Gly 
    1010                 1015                 1020             


Arg Pro  Asn Glu Thr Asp Ile  Lys Ile Arg Val Asn  Lys Phe Tyr 
    1025                 1030                 1035             


Arg Pro  Glu Asn Thr His Lys  Ser Thr Pro Ala Ser  Tyr His Ala 
    1040                 1045                 1050             


Asp Ile  Asn Leu Leu Tyr Trp  Ser Asp Glu Glu Ala  Val Val Asp 
    1055                 1060                 1065             


Phe Lys  Ala Val Gln Gly Arg  Cys Thr Val Glu Tyr  Gly Glu Asp 
    1070                 1075                 1080             


Leu Pro  Glu Cys Val Gln Val  Tyr Ser Met Gly Gly  Pro Asn Arg 
    1085                 1090                 1095             


Phe Tyr  Phe Leu Glu Ala Tyr  Asn Ala Lys Ser Lys  Ser Phe Glu 
    1100                 1105                 1110             


Asp Pro  Pro Asn His Ala Arg  Ser Pro Gly Asn Lys  Gly Lys Gly 
    1115                 1120                 1125             


Lys Gly  Lys Gly Lys Gly Lys  Pro Lys Ser Gln Ala  Cys Glu Pro 
    1130                 1135                 1140             


Ser Glu  Pro Glu Ile Glu Ile  Lys Leu Pro Lys Leu  Arg Thr Leu 
    1145                 1150                 1155             


Asp Val  Phe Ser Gly Cys Gly  Gly Leu Ser Glu Gly  Phe His Gln 
    1160                 1165                 1170             


Ala Gly  Ile Ser Asp Thr Leu  Trp Ala Ile Glu Met  Trp Asp Pro 
    1175                 1180                 1185             


Ala Ala  Gln Ala Phe Arg Leu  Asn Asn Pro Gly Ser  Thr Val Phe 
    1190                 1195                 1200             


Thr Glu  Asp Cys Asn Ile Leu  Leu Lys Leu Val Met  Ala Gly Glu 
    1205                 1210                 1215             


Thr Thr  Asn Ser Arg Gly Gln  Arg Leu Pro Gln Lys  Gly Asp Val 
    1220                 1225                 1230             


Glu Met  Leu Cys Gly Gly Pro  Pro Cys Gln Gly Phe  Ser Gly Met 
    1235                 1240                 1245             


Asn Arg  Phe Asn Ser Arg Thr  Tyr Ser Lys Phe Lys  Asn Ser Leu 
    1250                 1255                 1260             


Val Val  Ser Phe Leu Ser Tyr  Cys Asp Tyr Tyr Arg  Pro Arg Phe 
    1265                 1270                 1275             


Phe Leu  Leu Glu Asn Val Arg  Asn Phe Val Ser Phe  Lys Arg Ser 
    1280                 1285                 1290             


Met Val  Leu Lys Leu Thr Leu  Arg Cys Leu Val Arg  Met Gly Tyr 
    1295                 1300                 1305             


Gln Cys  Thr Phe Gly Val Leu  Gln Ala Gly Gln Tyr  Gly Val Ala 
    1310                 1315                 1320             


Gln Thr  Arg Arg Arg Ala Ile  Ile Leu Ala Ala Ala  Pro Gly Glu 
    1325                 1330                 1335             


Lys Leu  Pro Leu Phe Pro Glu  Pro Leu His Val Phe  Ala Pro Arg 
    1340                 1345                 1350             


Ala Cys  Gln Leu Ser Val Val  Val Asp Asp Lys Lys  Phe Val Ser 
    1355                 1360                 1365             


Asn Ile  Thr Arg Leu Ser Ser  Gly Pro Phe Arg Thr  Ile Thr Val 
    1370                 1375                 1380             


Arg Asp  Thr Met Ser Asp Leu  Pro Glu Val Arg Asn  Gly Ala Ser 
    1385                 1390                 1395             


Ala Leu  Glu Ile Ser Tyr Asn  Gly Glu Pro Gln Ser  Trp Phe Gln 
    1400                 1405                 1410             


Arg Gln  Leu Arg Gly Ala Gln  Tyr Gln Pro Ile Leu  Arg Asp His 
    1415                 1420                 1425             


Ile Cys  Lys Asp Met Ser Ala  Leu Val Ala Ala Arg  Met Arg His 
    1430                 1435                 1440             


Ile Pro  Leu Ala Pro Gly Ser  Asp Trp Arg Asp Leu  Pro Asn Ile 
    1445                 1450                 1455             


Glu Val  Arg Leu Ser Asp Gly  Thr Met Ala Arg Lys  Leu Arg Tyr 
    1460                 1465                 1470             


Thr His  His Asp Arg Lys Asn  Gly Arg Ser Ser Ser  Gly Ala Leu 
    1475                 1480                 1485             


Arg Gly  Val Cys Ser Cys Val  Glu Ala Gly Lys Ala  Cys Asp Pro 
    1490                 1495                 1500             


Ala Ala  Arg Gln Phe Asn Thr  Leu Ile Pro Trp Cys  Leu Pro His 
    1505                 1510                 1515             


Thr Gly  Asn Arg His Asn His  Trp Ala Gly Leu Tyr  Gly Arg Leu 
    1520                 1525                 1530             


Glu Trp  Asp Gly Phe Phe Ser  Thr Thr Val Thr Asn  Pro Glu Pro 
    1535                 1540                 1545             


Met Gly  Lys Gln Gly Arg Val  Leu His Pro Glu Gln  His Arg Val 
    1550                 1555                 1560             


Val Ser  Val Arg Glu Cys Ala  Arg Ser Gln Gly Phe  Pro Asp Thr 
    1565                 1570                 1575             


Tyr Arg  Leu Phe Gly Asn Ile  Leu Asp Lys His Arg  Gln Val Gly 
    1580                 1585                 1590             


Asn Ala  Val Pro Pro Pro Leu  Ala Lys Ala Ile Gly  Leu Glu Ile 
    1595                 1600                 1605             


Lys Leu  Cys Met Leu Ala Lys  Ala Arg Glu Ser Ala  Ser Ala Lys 
    1610                 1615                 1620             


Ile Lys  Glu Glu Glu Ala Ala  Lys Asp 
    1625                 1630         


<210>  3
<211>  386
<212>  PRT
<213>  Spiroplasma MQ-1

<400>  3

Met Ser Lys Val Glu Asn Lys Thr Lys Lys Leu Arg Val Phe Glu Ala 
1               5                   10                  15      


Phe Ala Gly Ile Gly Ala Gln Arg Lys Ala Leu Glu Lys Val Arg Lys 
            20                  25                  30          


Asp Glu Tyr Glu Ile Val Gly Leu Ala Glu Trp Tyr Val Pro Ala Ile 
        35                  40                  45              


Val Met Tyr Gln Ala Ile His Asn Asn Phe His Thr Lys Leu Glu Tyr 
    50                  55                  60                  


Lys Ser Val Ser Arg Glu Glu Met Ile Asp Tyr Leu Glu Asn Lys Thr 
65                  70                  75                  80  


Leu Ser Trp Asn Ser Lys Asn Pro Val Ser Asn Gly Tyr Trp Lys Arg 
                85                  90                  95      


Lys Lys Asp Asp Glu Leu Lys Ile Ile Tyr Asn Ala Ile Lys Leu Ser 
            100                 105                 110         


Glu Lys Glu Gly Asn Ile Phe Asp Ile Arg Asp Leu Tyr Lys Arg Thr 
        115                 120                 125             


Leu Lys Asn Ile Asp Leu Leu Thr Tyr Ser Phe Pro Cys Gln Asp Leu 
    130                 135                 140                 


Ser Gln Gln Gly Ile Gln Lys Gly Met Lys Arg Gly Ser Gly Thr Arg 
145                 150                 155                 160 


Ser Gly Leu Leu Trp Glu Ile Glu Arg Ala Leu Asp Ser Thr Glu Lys 
                165                 170                 175     


Asn Asp Leu Pro Lys Tyr Leu Leu Met Glu Asn Val Gly Ala Leu Leu 
            180                 185                 190         


His Lys Lys Asn Glu Glu Glu Leu Asn Gln Trp Lys Gln Lys Leu Glu 
        195                 200                 205             


Ser Leu Gly Tyr Gln Asn Ser Ile Glu Val Leu Asn Ala Ala Asp Phe 
    210                 215                 220                 


Gly Ser Ser Gln Ala Arg Arg Arg Val Phe Met Ile Ser Thr Leu Asn 
225                 230                 235                 240 


Glu Phe Val Glu Leu Pro Lys Gly Asp Lys Lys Pro Lys Ser Ile Lys 
                245                 250                 255     


Lys Val Leu Asn Lys Ile Val Ser Glu Lys Asp Ile Leu Asn Asn Leu 
            260                 265                 270         


Leu Lys Tyr Asn Leu Thr Glu Phe Lys Lys Thr Lys Ser Asn Ile Asn 
        275                 280                 285             


Lys Ala Ser Leu Ile Gly Tyr Ser Lys Phe Asn Ser Glu Gly Tyr Val 
    290                 295                 300                 


Tyr Asp Pro Glu Phe Thr Gly Pro Thr Leu Thr Ala Ser Gly Ala Asn 
305                 310                 315                 320 


Ser Arg Ile Lys Ile Lys Asp Gly Ser Asn Ile Arg Lys Met Asn Ser 
                325                 330                 335     


Asp Glu Thr Phe Leu Tyr Ile Gly Phe Asp Ser Gln Asp Gly Lys Arg 
            340                 345                 350         


Val Asn Glu Ile Glu Phe Leu Thr Glu Asn Gln Lys Ile Phe Val Cys 
        355                 360                 365             


Gly Asn Ser Ile Ser Val Glu Val Leu Glu Ala Ile Ile Asp Lys Ile 
    370                 375                 380                 


Gly Gly 
385     


<210>  4
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  The residue at this position is 5-methylcytosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  The residue at this position is 5-hydroxymethylcytosine

<400>  4
tcgatcgatc gt                                                           12


<210>  5
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  The residue at this position is 5-hydroxymethylcytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  The residue at this position is 5-methylcytosine

<400>  5
acgatcgatc ga                                                           12


<210>  6
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
acgatcgatc ga                                                           12


<210>  7
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  The residue at this position is 5-methylcytosine

<400>  7
acgatcgatc ga                                                           12


<210>  8
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  The residue at this position is 5-methylcytosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  The residue at this position is 5-hydroxymethylcytosine

<400>  8
tugatcgatc gt                                                           12


<210>  9
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ttgatcgatc gt                                                           12


