                         SEQUENCE LISTING

<110>  Colgate Palmolive
       Boyd, Thomas J.
       Xu, Guofeng
       Adams, Richard
       Pierce, Robert
       Miller, Steven
       Viscio, David
       DiCosimo, Robert
       Wang, Hong
       Fosser, Kari
 
<120>  PERACID-GENERATING COMPOSITIONS

<130>  9357-00-WO-OC

<150>  61/577,499
<151>  2011-12-19

<160>  197   

<170>  PatentIn version 3.5

<210>  1
<211>  325
<212>  PRT
<213>  Thermotoga maritima

<400>  1

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly 
                325 


<210>  2
<211>  375
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(325)
<223>  Thermotoma maritima C277S variant perhydrolase

<220>
<221>  MISC_FEATURE
<222>  (326)..(375)
<223>  Oral surface targeting domain

<400>  2

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly 
                325                 330                 335     


Ser Ala Gly Gly Pro Gly Ser Thr Lys Pro Pro Arg Thr Pro Thr Ala 
            340                 345                 350         


Asn Thr Ser Arg Pro His His Asn Phe Gly Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Pro His His His His His His 
    370                 375 


<210>  3
<211>  960
<212>  DNA
<213>  Bacillus subtilis


<220>
<221>  CDS
<222>  (1)..(960)

<400>  3
atg caa cta ttc gat ctg ccg ctc gac caa ttg caa aca tat aag cct         48
Met Gln Leu Phe Asp Leu Pro Leu Asp Gln Leu Gln Thr Tyr Lys Pro           
1               5                   10                  15                

gaa aaa aca gca ccg aaa gat ttt tct gag ttt tgg aaa ttg tct ttg         96
Glu Lys Thr Ala Pro Lys Asp Phe Ser Glu Phe Trp Lys Leu Ser Leu           
            20                  25                  30                    

gag gaa ctt gca aaa gtc caa gca gaa cct gat tta cag ccg gtt gac        144
Glu Glu Leu Ala Lys Val Gln Ala Glu Pro Asp Leu Gln Pro Val Asp           
        35                  40                  45                        

tat cct gct gac gga gta aaa gtg tac cgt ctc aca tat aaa agc ttc        192
Tyr Pro Ala Asp Gly Val Lys Val Tyr Arg Leu Thr Tyr Lys Ser Phe           
    50                  55                  60                            

gga aac gcc cgc att acc gga tgg tac gcg gtg cct gac aag caa ggc        240
Gly Asn Ala Arg Ile Thr Gly Trp Tyr Ala Val Pro Asp Lys Gln Gly           
65                  70                  75                  80            

ccg cat ccg gcg atc gtg aaa tat cat ggc tac aat gca agc tat gat        288
Pro His Pro Ala Ile Val Lys Tyr His Gly Tyr Asn Ala Ser Tyr Asp           
                85                  90                  95                

ggt gag att cat gaa atg gta aac tgg gca ctc cat ggc tac gcc gca        336
Gly Glu Ile His Glu Met Val Asn Trp Ala Leu His Gly Tyr Ala Ala           
            100                 105                 110                   

ttc ggc atg ctt gtc cgc ggc cag cag agc agc gag gat acg agt att        384
Phe Gly Met Leu Val Arg Gly Gln Gln Ser Ser Glu Asp Thr Ser Ile           
        115                 120                 125                       

tca ctg cac ggt cac gct ttg ggc tgg atg acg aaa gga att ctt gat        432
Ser Leu His Gly His Ala Leu Gly Trp Met Thr Lys Gly Ile Leu Asp           
    130                 135                 140                           

aaa gat aca tac tat tac cgc ggt gtt tat ttg gac gcc gtc cgc gcg        480
Lys Asp Thr Tyr Tyr Tyr Arg Gly Val Tyr Leu Asp Ala Val Arg Ala           
145                 150                 155                 160           

ctt gag gtc atc agc agc ttc gac gag gtt gac gaa aca agg atc ggt        528
Leu Glu Val Ile Ser Ser Phe Asp Glu Val Asp Glu Thr Arg Ile Gly           
                165                 170                 175               

gtg aca gga gga agc caa ggc gga ggt tta acc att gcc gca gca gcg        576
Val Thr Gly Gly Ser Gln Gly Gly Gly Leu Thr Ile Ala Ala Ala Ala           
            180                 185                 190                   

ctg tca gac att cca aaa gcc gcg gtt gcc gat tat cct tat tta agc        624
Leu Ser Asp Ile Pro Lys Ala Ala Val Ala Asp Tyr Pro Tyr Leu Ser           
        195                 200                 205                       

aac ttc gaa cgg gcc att gat gtg gcg ctt gaa cag ccg tac ctt gaa        672
Asn Phe Glu Arg Ala Ile Asp Val Ala Leu Glu Gln Pro Tyr Leu Glu           
    210                 215                 220                           

atc aat tcc ttc ttc aga aga aat ggc agc ccg gaa aca gaa gtg cag        720
Ile Asn Ser Phe Phe Arg Arg Asn Gly Ser Pro Glu Thr Glu Val Gln           
225                 230                 235                 240           

gcg atg aag aca ctt tca tat ttc gat att atg aat ctc gct gac cga        768
Ala Met Lys Thr Leu Ser Tyr Phe Asp Ile Met Asn Leu Ala Asp Arg           
                245                 250                 255               

gtg aag gtg cct gtc ctg atg tca atc ggc ctg att gac aag gtc acg        816
Val Lys Val Pro Val Leu Met Ser Ile Gly Leu Ile Asp Lys Val Thr           
            260                 265                 270                   

ccg ccg tcc acc gtg ttt gcc gcc tac aat cat ttg gaa aca gag aaa        864
Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His Leu Glu Thr Glu Lys           
        275                 280                 285                       

gag ctg aag gtg tac cgc tac ttc gga cat gag tat atc cct gct ttt        912
Glu Leu Lys Val Tyr Arg Tyr Phe Gly His Glu Tyr Ile Pro Ala Phe           
    290                 295                 300                           

caa acg gaa aaa ctt gct ttc ttt aag cag cat ctt aaa ggc tga taa        960
Gln Thr Glu Lys Leu Ala Phe Phe Lys Gln His Leu Lys Gly                   
305                 310                 315                               


<210>  4
<211>  318
<212>  PRT
<213>  Bacillus subtilis

<400>  4

Met Gln Leu Phe Asp Leu Pro Leu Asp Gln Leu Gln Thr Tyr Lys Pro 
1               5                   10                  15      


Glu Lys Thr Ala Pro Lys Asp Phe Ser Glu Phe Trp Lys Leu Ser Leu 
            20                  25                  30          


Glu Glu Leu Ala Lys Val Gln Ala Glu Pro Asp Leu Gln Pro Val Asp 
        35                  40                  45              


Tyr Pro Ala Asp Gly Val Lys Val Tyr Arg Leu Thr Tyr Lys Ser Phe 
    50                  55                  60                  


Gly Asn Ala Arg Ile Thr Gly Trp Tyr Ala Val Pro Asp Lys Gln Gly 
65                  70                  75                  80  


Pro His Pro Ala Ile Val Lys Tyr His Gly Tyr Asn Ala Ser Tyr Asp 
                85                  90                  95      


Gly Glu Ile His Glu Met Val Asn Trp Ala Leu His Gly Tyr Ala Ala 
            100                 105                 110         


Phe Gly Met Leu Val Arg Gly Gln Gln Ser Ser Glu Asp Thr Ser Ile 
        115                 120                 125             


Ser Leu His Gly His Ala Leu Gly Trp Met Thr Lys Gly Ile Leu Asp 
    130                 135                 140                 


Lys Asp Thr Tyr Tyr Tyr Arg Gly Val Tyr Leu Asp Ala Val Arg Ala 
145                 150                 155                 160 


Leu Glu Val Ile Ser Ser Phe Asp Glu Val Asp Glu Thr Arg Ile Gly 
                165                 170                 175     


Val Thr Gly Gly Ser Gln Gly Gly Gly Leu Thr Ile Ala Ala Ala Ala 
            180                 185                 190         


Leu Ser Asp Ile Pro Lys Ala Ala Val Ala Asp Tyr Pro Tyr Leu Ser 
        195                 200                 205             


Asn Phe Glu Arg Ala Ile Asp Val Ala Leu Glu Gln Pro Tyr Leu Glu 
    210                 215                 220                 


Ile Asn Ser Phe Phe Arg Arg Asn Gly Ser Pro Glu Thr Glu Val Gln 
225                 230                 235                 240 


Ala Met Lys Thr Leu Ser Tyr Phe Asp Ile Met Asn Leu Ala Asp Arg 
                245                 250                 255     


Val Lys Val Pro Val Leu Met Ser Ile Gly Leu Ile Asp Lys Val Thr 
            260                 265                 270         


Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His Leu Glu Thr Glu Lys 
        275                 280                 285             


Glu Leu Lys Val Tyr Arg Tyr Phe Gly His Glu Tyr Ile Pro Ala Phe 
    290                 295                 300                 


Gln Thr Glu Lys Leu Ala Phe Phe Lys Gln His Leu Lys Gly 
305                 310                 315             


<210>  5
<211>  318
<212>  PRT
<213>  Bacillus subtilis

<400>  5

Met Gln Leu Phe Asp Leu Pro Leu Asp Gln Leu Gln Thr Tyr Lys Pro 
1               5                   10                  15      


Glu Lys Thr Ala Pro Lys Asp Phe Ser Glu Phe Trp Lys Leu Ser Leu 
            20                  25                  30          


Glu Glu Leu Ala Lys Val Gln Ala Glu Pro Asp Leu Gln Pro Val Asp 
        35                  40                  45              


Tyr Pro Ala Asp Gly Val Lys Val Tyr Arg Leu Thr Tyr Lys Ser Phe 
    50                  55                  60                  


Gly Asn Ala Arg Ile Thr Gly Trp Tyr Ala Val Pro Asp Lys Glu Gly 
65                  70                  75                  80  


Pro His Pro Ala Ile Val Lys Tyr His Gly Tyr Asn Ala Ser Tyr Asp 
                85                  90                  95      


Gly Glu Ile His Glu Met Val Asn Trp Ala Leu His Gly Tyr Ala Thr 
            100                 105                 110         


Phe Gly Met Leu Val Arg Gly Gln Gln Ser Ser Glu Asp Thr Ser Ile 
        115                 120                 125             


Ser Pro His Gly His Ala Leu Gly Trp Met Thr Lys Gly Ile Leu Asp 
    130                 135                 140                 


Lys Asp Thr Tyr Tyr Tyr Arg Gly Val Tyr Leu Asp Ala Val Arg Ala 
145                 150                 155                 160 


Leu Glu Val Ile Ser Ser Phe Asp Glu Val Asp Glu Thr Arg Ile Gly 
                165                 170                 175     


Val Thr Gly Gly Ser Gln Gly Gly Gly Leu Thr Ile Ala Ala Ala Ala 
            180                 185                 190         


Leu Ser Asp Ile Pro Lys Ala Ala Val Ala Asp Tyr Pro Tyr Leu Ser 
        195                 200                 205             


Asn Phe Glu Arg Ala Ile Asp Val Ala Leu Glu Gln Pro Tyr Leu Glu 
    210                 215                 220                 


Ile Asn Ser Phe Phe Arg Arg Asn Gly Ser Pro Glu Thr Glu Val Gln 
225                 230                 235                 240 


Ala Met Lys Thr Leu Ser Tyr Phe Asp Ile Met Asn Leu Ala Asp Arg 
                245                 250                 255     


Val Lys Val Pro Val Leu Met Ser Ile Gly Leu Ile Asp Lys Val Thr 
            260                 265                 270         


Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His Leu Glu Thr Lys Lys 
        275                 280                 285             


Glu Leu Lys Val Tyr Arg Tyr Phe Gly His Glu Tyr Ile Pro Ala Phe 
    290                 295                 300                 


Gln Thr Glu Lys Leu Ala Phe Phe Lys Gln His Leu Lys Gly 
305                 310                 315             


<210>  6
<211>  318
<212>  PRT
<213>  Bacillus subtilis

<400>  6

Met Gln Leu Phe Asp Leu Pro Leu Asp Gln Leu Gln Thr Tyr Lys Pro 
1               5                   10                  15      


Glu Lys Thr Thr Pro Asn Asp Phe Ser Glu Phe Trp Lys Ser Ser Leu 
            20                  25                  30          


Asp Glu Leu Ala Lys Val Lys Ala Ala Pro Asp Leu Gln Leu Val Asp 
        35                  40                  45              


Tyr Pro Ala Asp Gly Val Lys Val Tyr Arg Leu Thr Tyr Lys Ser Phe 
    50                  55                  60                  


Gly Asn Ala Arg Ile Thr Gly Trp Tyr Ala Val Pro Asp Lys Glu Gly 
65                  70                  75                  80  


Pro His Pro Ala Ile Val Lys Tyr His Gly Tyr Asn Ala Ser Tyr Asp 
                85                  90                  95      


Gly Glu Ile His Glu Met Val Asn Trp Ala Leu His Gly Tyr Ala Ala 
            100                 105                 110         


Phe Gly Met Leu Val Arg Gly Gln Gln Ser Ser Glu Asp Thr Ser Ile 
        115                 120                 125             


Ser Pro His Gly His Ala Leu Gly Trp Met Thr Lys Gly Ile Leu Asp 
    130                 135                 140                 


Lys Asp Thr Tyr Tyr Tyr Arg Gly Val Tyr Leu Asp Ala Val Arg Ala 
145                 150                 155                 160 


Leu Glu Val Ile Ser Ser Phe Asp Glu Val Asp Glu Thr Arg Ile Gly 
                165                 170                 175     


Val Thr Gly Gly Ser Gln Gly Gly Gly Leu Thr Ile Ala Ala Ala Ala 
            180                 185                 190         


Leu Ser Asp Ile Pro Lys Ala Ala Val Ala Asp Tyr Pro Tyr Leu Ser 
        195                 200                 205             


Asn Phe Glu Arg Ala Ile Asp Val Ala Leu Glu Gln Pro Tyr Leu Glu 
    210                 215                 220                 


Ile Asn Ser Phe Phe Arg Arg Asn Gly Ser Pro Glu Thr Glu Glu Lys 
225                 230                 235                 240 


Ala Met Lys Thr Leu Ser Tyr Phe Asp Ile Met Asn Leu Ala Asp Arg 
                245                 250                 255     


Val Lys Val Pro Val Leu Met Ser Ile Gly Leu Ile Asp Lys Val Thr 
            260                 265                 270         


Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His Leu Glu Thr Glu Lys 
        275                 280                 285             


Glu Leu Lys Val Tyr Arg Tyr Phe Gly His Glu Tyr Ile Pro Ala Phe 
    290                 295                 300                 


Gln Thr Glu Lys Leu Ala Phe Phe Lys Gln His Leu Lys Gly 
305                 310                 315             


<210>  7
<211>  318
<212>  PRT
<213>  Bacillus licheniformis

<400>  7

Met Gln Gln Pro Tyr Asp Met Pro Leu Glu Gln Leu Tyr Gln Tyr Lys 
1               5                   10                  15      


Pro Glu Arg Thr Ala Pro Ala Asp Phe Lys Glu Phe Trp Lys Gly Ser 
            20                  25                  30          


Leu Glu Glu Leu Ala Asn Glu Lys Ala Gly Pro Gln Leu Glu Pro His 
        35                  40                  45              


Glu Tyr Pro Ala Asp Gly Val Lys Val Tyr Trp Leu Thr Tyr Arg Ser 
    50                  55                  60                  


Ile Gly Gly Ala Arg Ile Lys Gly Trp Tyr Ala Val Pro Asp Arg Gln 
65                  70                  75                  80  


Gly Pro His Pro Ala Ile Val Lys Tyr His Gly Tyr Asn Ala Ser Tyr 
                85                  90                  95      


Asp Gly Asp Ile His Asp Ile Val Asn Trp Ala Leu His Gly Tyr Ala 
            100                 105                 110         


Ala Phe Gly Met Leu Val Arg Gly Gln Asn Ser Ser Glu Asp Thr Glu 
        115                 120                 125             


Ile Ser His His Gly His Val Pro Gly Trp Met Thr Lys Gly Ile Leu 
    130                 135                 140                 


Asp Pro Lys Thr Tyr Tyr Tyr Arg Gly Val Tyr Leu Asp Ala Val Arg 
145                 150                 155                 160 


Ala Val Glu Val Val Ser Gly Phe Ala Glu Val Asp Glu Lys Arg Ile 
                165                 170                 175     


Gly Val Ile Gly Ala Ser Gln Gly Gly Gly Leu Ala Val Ala Val Ser 
            180                 185                 190         


Ala Leu Ser Asp Ile Pro Lys Ala Ala Val Ser Glu Tyr Pro Tyr Leu 
        195                 200                 205             


Ser Asn Phe Gln Arg Ala Ile Asp Thr Ala Ile Asp Gln Pro Tyr Leu 
    210                 215                 220                 


Glu Ile Asn Ser Phe Phe Arg Arg Asn Thr Ser Pro Asp Ile Glu Gln 
225                 230                 235                 240 


Ala Ala Met His Thr Leu Ser Tyr Phe Asp Val Met Asn Leu Ala Gln 
                245                 250                 255     


Leu Val Lys Ala Thr Val Leu Met Ser Ile Gly Leu Val Asp Thr Ile 
            260                 265                 270         


Thr Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His Leu Glu Thr Asp 
        275                 280                 285             


Lys Glu Ile Lys Val Tyr Arg Tyr Phe Gly His Glu Tyr Ile Pro Pro 
    290                 295                 300                 


Phe Gln Thr Glu Lys Leu Ala Phe Leu Arg Lys His Leu Lys 
305                 310                 315             


<210>  8
<211>  320
<212>  PRT
<213>  Bacillus pumilus

<400>  8

Met Gln Leu Phe Asp Leu Ser Leu Glu Glu Leu Lys Lys Tyr Lys Pro 
1               5                   10                  15      


Lys Lys Thr Ala Arg Pro Asp Phe Ser Asp Phe Trp Lys Lys Ser Leu 
            20                  25                  30          


Glu Glu Leu Arg Gln Val Glu Ala Glu Pro Thr Leu Glu Ser Tyr Asp 
        35                  40                  45              


Tyr Pro Val Lys Gly Val Lys Val Tyr Arg Leu Thr Tyr Gln Ser Phe 
    50                  55                  60                  


Gly His Ser Lys Ile Glu Gly Phe Tyr Ala Val Pro Asp Gln Thr Gly 
65                  70                  75                  80  


Pro His Pro Ala Leu Val Arg Phe His Gly Tyr Asn Ala Ser Tyr Asp 
                85                  90                  95      


Gly Gly Ile His Asp Ile Val Asn Trp Ala Leu His Gly Tyr Ala Thr 
            100                 105                 110         


Phe Gly Met Leu Val Arg Gly Gln Gly Gly Ser Glu Asp Thr Ser Val 
        115                 120                 125             


Thr Pro Gly Gly His Ala Leu Gly Trp Met Thr Lys Gly Ile Leu Ser 
    130                 135                 140                 


Lys Asp Thr Tyr Tyr Tyr Arg Gly Val Tyr Leu Asp Ala Val Arg Ala 
145                 150                 155                 160 


Leu Glu Val Ile Gln Ser Phe Pro Glu Val Asp Glu His Arg Ile Gly 
                165                 170                 175     


Val Ile Gly Gly Ser Gln Gly Gly Ala Leu Ala Ile Ala Ala Ala Ala 
            180                 185                 190         


Leu Ser Asp Ile Pro Lys Val Val Val Ala Asp Tyr Pro Tyr Leu Ser 
        195                 200                 205             


Asn Phe Glu Arg Ala Val Asp Val Ala Leu Glu Gln Pro Tyr Leu Glu 
    210                 215                 220                 


Ile Asn Ser Tyr Phe Arg Arg Asn Ser Asp Pro Lys Val Glu Glu Lys 
225                 230                 235                 240 


Ala Phe Glu Thr Leu Ser Tyr Phe Asp Leu Ile Asn Leu Ala Gly Trp 
                245                 250                 255     


Val Lys Gln Pro Thr Leu Met Ala Ile Gly Leu Ile Asp Lys Ile Thr 
            260                 265                 270         


Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His Leu Glu Thr Asp Lys 
        275                 280                 285             


Asp Leu Lys Val Tyr Arg Tyr Phe Gly His Glu Phe Ile Pro Ala Phe 
    290                 295                 300                 


Gln Thr Glu Lys Leu Ser Phe Leu Gln Lys His Leu Leu Leu Ser Thr 
305                 310                 315                 320 


<210>  9
<211>  320
<212>  PRT
<213>  Clostridium thermocellum

<400>  9

Met Ala Gln Leu Tyr Asp Met Pro Leu Glu Glu Leu Lys Lys Tyr Lys 
1               5                   10                  15      


Pro Ala Leu Thr Lys Gln Lys Asp Phe Asp Glu Phe Trp Glu Lys Ser 
            20                  25                  30          


Leu Lys Glu Leu Ala Glu Ile Pro Leu Lys Tyr Gln Leu Ile Pro Tyr 
        35                  40                  45              


Asp Phe Pro Ala Arg Arg Val Lys Val Phe Arg Val Glu Tyr Leu Gly 
    50                  55                  60                  


Phe Lys Gly Ala Asn Ile Glu Gly Trp Leu Ala Val Pro Glu Gly Glu 
65                  70                  75                  80  


Gly Leu Tyr Pro Gly Leu Val Gln Phe His Gly Tyr Asn Trp Ala Met 
                85                  90                  95      


Asp Gly Cys Val Pro Asp Val Val Asn Trp Ala Leu Asn Gly Tyr Ala 
            100                 105                 110         


Ala Phe Leu Met Leu Val Arg Gly Gln Gln Gly Arg Ser Val Asp Asn 
        115                 120                 125             


Ile Val Pro Gly Ser Gly His Ala Leu Gly Trp Met Ser Lys Gly Ile 
    130                 135                 140                 


Leu Ser Pro Glu Glu Tyr Tyr Tyr Arg Gly Val Tyr Met Asp Ala Val 
145                 150                 155                 160 


Arg Ala Val Glu Ile Leu Ala Ser Leu Pro Cys Val Asp Glu Ser Arg 
                165                 170                 175     


Ile Gly Val Thr Gly Gly Ser Gln Gly Gly Gly Leu Ala Leu Ala Val 
            180                 185                 190         


Ala Ala Leu Ser Gly Ile Pro Lys Val Ala Ala Val His Tyr Pro Phe 
        195                 200                 205             


Leu Ala His Phe Glu Arg Ala Ile Asp Val Ala Pro Asp Gly Pro Tyr 
    210                 215                 220                 


Leu Glu Ile Asn Glu Tyr Leu Arg Arg Asn Ser Gly Glu Glu Ile Glu 
225                 230                 235                 240 


Arg Gln Val Lys Lys Thr Leu Ser Tyr Phe Asp Ile Met Asn Leu Ala 
                245                 250                 255     


Pro Arg Ile Lys Cys Arg Thr Trp Ile Cys Thr Gly Leu Val Asp Glu 
            260                 265                 270         


Ile Thr Pro Pro Ser Thr Val Phe Ala Val Tyr Asn His Leu Lys Cys 
        275                 280                 285             


Pro Lys Glu Ile Ser Val Phe Arg Tyr Phe Gly His Glu His Met Pro 
    290                 295                 300                 


Gly Ser Val Glu Ile Lys Leu Arg Ile Leu Met Asp Glu Leu Asn Pro 
305                 310                 315                 320 


<210>  10
<211>  325
<212>  PRT
<213>  Thermotoga neapolitana

<400>  10

Met Ala Phe Phe Asp Met Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Arg Glu Thr Leu 
            20                  25                  30          


Lys Glu Ser Glu Gly Phe Pro Leu Asp Pro Val Phe Glu Lys Val Asp 
        35                  40                  45              


Phe His Leu Lys Thr Val Glu Thr Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Ala Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Met Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Gly Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Val Asp Ala Val Arg Ala Val Glu Ala Ala Ile Ser Phe Pro Arg 
                165                 170                 175     


Val Asp Ser Arg Lys Val Val Val Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Asn Arg Val Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Val Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Val Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Thr Ile Cys Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Ile Glu Gln Val Lys Phe Leu Lys Arg 
305                 310                 315                 320 


Leu Phe Glu Glu Gly 
                325 


<210>  11
<211>  325
<212>  PRT
<213>  Thermotoga maritima

<400>  11

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Cys Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly 
                325 


<210>  12
<211>  320
<212>  PRT
<213>  Thermoanaerobacterium sp.

<400>  12

Met Gly Leu Phe Asp Met Pro Leu Gln Lys Leu Arg Glu Tyr Thr Gly 
1               5                   10                  15      


Thr Asn Pro Cys Pro Glu Asp Phe Asp Glu Tyr Trp Asn Arg Ala Leu 
            20                  25                  30          


Asp Glu Met Arg Ser Val Asp Pro Lys Ile Glu Leu Lys Glu Ser Ser 
        35                  40                  45              


Phe Gln Val Ser Phe Ala Glu Cys Tyr Asp Leu Tyr Phe Thr Gly Val 
    50                  55                  60                  


Arg Gly Ala Arg Ile His Ala Lys Tyr Ile Lys Pro Lys Thr Glu Gly 
65                  70                  75                  80  


Lys His Pro Ala Leu Ile Arg Phe His Gly Tyr Ser Ser Asn Ser Gly 
                85                  90                  95      


Asp Trp Asn Asp Lys Leu Asn Tyr Val Ala Ala Gly Phe Thr Val Val 
            100                 105                 110         


Ala Met Asp Val Arg Gly Gln Gly Gly Gln Ser Gln Asp Val Gly Gly 
        115                 120                 125             


Val Thr Gly Asn Thr Leu Asn Gly His Ile Ile Arg Gly Leu Asp Asp 
    130                 135                 140                 


Asp Ala Asp Asn Met Leu Phe Arg His Ile Phe Leu Asp Thr Ala Gln 
145                 150                 155                 160 


Leu Ala Gly Ile Val Met Asn Met Pro Glu Val Asp Glu Asp Arg Val 
                165                 170                 175     


Gly Val Met Gly Pro Ser Gln Gly Gly Gly Leu Ser Leu Ala Cys Ala 
            180                 185                 190         


Ala Leu Glu Pro Arg Val Arg Lys Val Val Ser Glu Tyr Pro Phe Leu 
        195                 200                 205             


Ser Asp Tyr Lys Arg Val Trp Asp Leu Asp Leu Ala Lys Asn Ala Tyr 
    210                 215                 220                 


Gln Glu Ile Thr Asp Tyr Phe Arg Leu Phe Asp Pro Arg His Glu Arg 
225                 230                 235                 240 


Glu Asn Glu Val Phe Thr Lys Leu Gly Tyr Ile Asp Val Lys Asn Leu 
                245                 250                 255     


Ala Lys Arg Ile Lys Gly Asp Val Leu Met Cys Val Gly Leu Met Asp 
            260                 265                 270         


Gln Val Cys Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Asn Ile Gln 
        275                 280                 285             


Ser Lys Lys Asp Ile Lys Val Tyr Pro Asp Tyr Gly His Glu Pro Met 
    290                 295                 300                 


Arg Gly Phe Gly Asp Leu Ala Met Gln Phe Met Leu Glu Leu Tyr Ser 
305                 310                 315                 320 


<210>  13
<211>  319
<212>  PRT
<213>  Bacillus halodurans

<400>  13

Met Pro Leu Ile Asp Met Pro Leu Thr Glu Leu Lys Glu Tyr Met Gly 
1               5                   10                  15      


Arg Asn Pro Lys Pro Asp Asp Phe Thr Glu Tyr Trp Asp Arg Ala Leu 
            20                  25                  30          


Gln Glu Met Arg Lys Val Asn Pro Asn Val Glu Leu Ile Pro Ser Asp 
        35                  40                  45              


Phe Gln Thr Thr Tyr Ala Glu Cys Phe His Leu Tyr Phe Thr Gly Val 
    50                  55                  60                  


Arg Gly Ala Arg Ile His Ala Lys Tyr Val Arg Pro Arg His Thr Ser 
65                  70                  75                  80  


Gly Thr His Pro Ala Val Ile His Phe His Gly Tyr Thr Met Asn Ala 
                85                  90                  95      


Gly Glu Trp Thr Gly Leu Leu His Tyr Ala Ala Leu Gly Tyr Ser Val 
            100                 105                 110         


Leu Ala Met Asp Val Arg Gly Gln Gly Gly Leu Ser Glu Asp Thr Gly 
        115                 120                 125             


Gly Val Lys Gly Asn Thr His Ser Gly His Ile Ile Arg Gly Leu Asp 
    130                 135                 140                 


Asp Asn Ala Asp Gln Leu Leu Phe Arg His Val Phe Leu Asp Thr Ala 
145                 150                 155                 160 


Gln Leu Ala Asn Ile Val Met Asn Leu Pro Glu Val Asp Glu Glu Arg 
                165                 170                 175     


Val Ala Val Thr Gly Trp Ser Gln Gly Gly Ala Leu Ala Ile Ala Cys 
            180                 185                 190         


Ala Ala Leu Glu Pro Lys Ile Lys Lys Val Ala Pro Val Tyr Pro Phe 
        195                 200                 205             


Leu Ser Asp Tyr Gln Arg Val Trp Glu Met Asp Leu Ala Glu Lys Ala 
    210                 215                 220                 


Tyr Asp Glu Leu Gln Thr Tyr Phe Arg Arg Phe Asp Pro Gln His Arg 
225                 230                 235                 240 


Arg Glu Ala Glu Ile Phe Thr Lys Leu Gly Tyr Ile Asp Ile Gln His 
                245                 250                 255     


Leu Ala Pro Leu Val Lys Gly Glu Val Leu Leu Ala Val Gly Leu Met 
            260                 265                 270         


Asp Thr Val Cys Pro Pro Ser Thr Gln Phe Ala Met Tyr Asn Lys Leu 
        275                 280                 285             


Thr Thr Thr Lys Ser Ile Glu Leu Tyr Pro Asp Phe Ala His Glu Asp 
    290                 295                 300                 


Leu Pro Gly His Arg Asp Arg Ile Phe Gln Phe Leu Ser Asp Leu 
305                 310                 315                 


<210>  14
<211>  317
<212>  PRT
<213>  Bacillus clausii

<400>  14

Met Pro Leu Val Asp Met Pro Leu Arg Glu Leu Leu Ala Tyr Glu Gly 
1               5                   10                  15      


Ile Asn Pro Lys Pro Ala Asp Phe Asp Gln Tyr Trp Asn Arg Ala Lys 
            20                  25                  30          


Thr Glu Ile Glu Ala Ile Asp Pro Glu Val Thr Leu Val Glu Ser Ser 
        35                  40                  45              


Phe Gln Cys Ser Phe Ala Asn Cys Tyr His Phe Tyr Tyr Arg Ser Ala 
    50                  55                  60                  


Gly Asn Ala Lys Ile His Ala Lys Tyr Val Gln Pro Lys Ala Gly Glu 
65                  70                  75                  80  


Lys Thr Pro Ala Val Phe Met Phe His Gly Tyr Gly Gly Arg Ser Ala 
                85                  90                  95      


Glu Trp Ser Ser Leu Leu Asn Tyr Val Ala Ala Gly Phe Ser Val Phe 
            100                 105                 110         


Tyr Met Asp Val Arg Gly Gln Gly Gly Thr Ser Glu Asp Pro Gly Gly 
        115                 120                 125             


Val Arg Gly Asn Thr Tyr Arg Gly His Ile Ile Arg Gly Leu Asp Ala 
    130                 135                 140                 


Gly Pro Asp Ala Leu Phe Tyr Arg Ser Val Phe Leu Asp Thr Val Gln 
145                 150                 155                 160 


Leu Val Arg Ala Ala Lys Thr Leu Pro His Ile Asp Lys Thr Arg Leu 
                165                 170                 175     


Met Ala Thr Gly Trp Ser Gln Gly Gly Ala Leu Thr Leu Ala Cys Ala 
            180                 185                 190         


Ala Leu Val Pro Glu Ile Lys Arg Leu Ala Pro Val Tyr Pro Phe Leu 
        195                 200                 205             


Ser Asp Tyr Lys Arg Val Trp Gln Met Asp Leu Ala Val Arg Ser Tyr 
    210                 215                 220                 


Lys Glu Leu Ala Asp Tyr Phe Arg Ser Tyr Asp Pro Gln His Lys Arg 
225                 230                 235                 240 


His Gly Glu Ile Phe Glu Arg Leu Gly Tyr Ile Asp Val Gln His Leu 
                245                 250                 255     


Ala Asp Arg Ile Gln Gly Asp Val Leu Met Gly Val Gly Leu Met Asp 
            260                 265                 270         


Thr Glu Cys Pro Pro Ser Thr Gln Phe Ala Ala Tyr Asn Lys Ile Lys 
        275                 280                 285             


Ala Lys Lys Ser Tyr Glu Leu Tyr Pro Asp Phe Gly His Glu His Leu 
    290                 295                 300                 


Pro Gly Met Asn Asp His Ile Phe Arg Phe Phe Thr Ser 
305                 310                 315         


<210>  15
<211>  325
<212>  PRT
<213>  Thermotoga neapolitana


<220>
<221>  MISC_FEATURE
<222>  (277)..(277)
<223>  Xaa is Ala, Val, Ser, or Thr.

<400>  15

Met Ala Phe Phe Asp Met Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Arg Glu Thr Leu 
            20                  25                  30          


Lys Glu Ser Glu Gly Phe Pro Leu Asp Pro Val Phe Glu Lys Val Asp 
        35                  40                  45              


Phe His Leu Lys Thr Val Glu Thr Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Ala Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Met Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Gly Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Val Asp Ala Val Arg Ala Val Glu Ala Ala Ile Ser Phe Pro Arg 
                165                 170                 175     


Val Asp Ser Arg Lys Val Val Val Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Asn Arg Val Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Val Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Val Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Thr Ile Xaa Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Ile Glu Gln Val Lys Phe Leu Lys Arg 
305                 310                 315                 320 


Leu Phe Glu Glu Gly 
                325 


<210>  16
<211>  325
<212>  PRT
<213>  Thermotoga maritima


<220>
<221>  MISC_FEATURE
<222>  (277)..(277)
<223>  Xaa is Ala, Val, Ser, or Thr.

<400>  16

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Xaa Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly 
                325 


<210>  17
<211>  326
<212>  PRT
<213>  Thermotoga lettingae


<220>
<221>  MISC_FEATURE
<222>  (277)..(277)
<223>  Xaa is Ala, Val, Ser, or Thr.

<400>  17

Met Val Tyr Phe Asp Met Pro Leu Glu Asp Leu Arg Lys Tyr Leu Pro 
1               5                   10                  15      


Gln Arg Tyr Glu Glu Lys Asp Phe Asp Asp Phe Trp Lys Gln Thr Ile 
            20                  25                  30          


His Glu Thr Arg Gly Tyr Phe Gln Glu Pro Ile Leu Lys Lys Val Asp 
        35                  40                  45              


Phe Tyr Leu Gln Asn Val Glu Thr Phe Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Lys Ile Lys Gly Trp Leu Ile Leu Pro Lys Phe Arg Asn 
65                  70                  75                  80  


Gly Lys Leu Pro Cys Val Val Glu Phe Val Gly Tyr Gly Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro Tyr Asp Trp Leu Leu Trp Ser Ala Ala Gly Tyr Ala His 
            100                 105                 110         


Phe Ile Met Asp Thr Arg Gly Gln Gly Ser Asn Trp Met Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Glu Asp Asn Pro Ser Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Leu Thr Lys Gly Val Leu Asn Pro Glu Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Met Asp Ala Phe Met Ala Val Glu Thr Ile Ser Gln Leu Glu Gln 
                165                 170                 175     


Ile Asp Ser Gln Thr Ile Ile Leu Ser Gly Ala Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Ser Lys Val Met Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Tyr Lys Arg Ala Val Gln Ile Thr 
    210                 215                 220                 


Asp Ser Met Pro Tyr Ala Glu Ile Thr Arg Tyr Cys Lys Thr His Ile 
225                 230                 235                 240 


Asp Lys Ile Gln Thr Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Cys Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asp Ile Xaa Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Glu Lys Asp Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe His Thr Leu Glu Lys Leu Lys Phe Val Lys Lys 
305                 310                 315                 320 


Thr Ile Ser Met Arg Glu 
                325     


<210>  18
<211>  325
<212>  PRT
<213>  Thermotoga petrophilia


<220>
<221>  MISC_FEATURE
<222>  (277)..(277)
<223>  Xaa is Ala, Val, Ser, or Thr.

<400>  18

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Gly Thr Leu 
            20                  25                  30          


Ala Glu Asn Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Met Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Met Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Asp Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Arg 
                165                 170                 175     


Val Asp His Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Val Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Xaa Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Ile Glu Gln Val Lys Phe Leu Lys Arg 
305                 310                 315                 320 


Leu Phe Glu Lys Gly 
                325 


<210>  19
<211>  325
<212>  PRT
<213>  Thermotoga sp. RQ2a


<220>
<221>  MISC_FEATURE
<222>  (277)..(277)
<223>  Xaa is Ala, Val, Ser, or Thr.

<400>  19

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Lys Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Val Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Asp Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Arg 
                165                 170                 175     


Val Asp His Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Val Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Xaa Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Ile Glu Gln Val Lys Phe Leu Lys Arg 
305                 310                 315                 320 


Leu Phe Glu Lys Gly 
                325 


<210>  20
<211>  329
<212>  PRT
<213>  Thermotoga sp. RQ2b


<220>
<221>  MISC_FEATURE
<222>  (278)..(278)
<223>  Xaa is Ala, Val, Ser, or Thr.

<400>  20

Met Ala Leu Phe Asp Met Pro Leu Glu Lys Leu Arg Ser Tyr Leu Pro 
1               5                   10                  15      


Asp Arg Tyr Glu Glu Glu Asp Phe Asp Leu Phe Trp Lys Glu Thr Leu 
            20                  25                  30          


Glu Glu Ser Arg Lys Phe Pro Leu Asp Pro Ile Phe Glu Arg Val Asp 
        35                  40                  45              


Tyr Leu Leu Glu Asn Val Glu Val Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Ala Trp Leu Ile Leu Pro Val Val Lys Lys 
65                  70                  75                  80  


Glu Glu Arg Leu Pro Cys Ile Val Glu Phe Ile Gly Tyr Arg Gly Gly 
                85                  90                  95      


Arg Gly Phe Pro Phe Asp Trp Leu Phe Trp Ser Ser Ala Gly Tyr Ala 
            100                 105                 110         


His Phe Val Met Asp Thr Arg Gly Gln Gly Thr Ser Arg Val Lys Gly 
        115                 120                 125             


Asp Thr Pro Asp Tyr Cys Asp Glu Pro Ile Asn Pro Gln Phe Pro Gly 
    130                 135                 140                 


Phe Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg 
145                 150                 155                 160 


Val Phe Thr Asp Ala Val Arg Ala Val Glu Thr Ala Ser Ser Phe Pro 
                165                 170                 175     


Gly Ile Asp Pro Glu Arg Ile Ala Val Val Gly Thr Ser Gln Gly Gly 
            180                 185                 190         


Gly Ile Ala Leu Ala Val Ala Ala Leu Ser Glu Ile Pro Lys Ala Leu 
        195                 200                 205             


Val Ser Asn Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Ile 
    210                 215                 220                 


Thr Asp Asn Ala Pro Tyr Ser Glu Ile Val Asn Tyr Leu Lys Val His 
225                 230                 235                 240 


Arg Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly 
                245                 250                 255     


Val Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Ala 
            260                 265                 270         


Leu Met Asp Lys Thr Xaa Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn 
        275                 280                 285             


His Tyr Ala Gly Pro Lys Glu Ile Lys Val Tyr Pro Phe Asn Glu His 
    290                 295                 300                 


Glu Gly Gly Glu Ser Phe Gln Arg Met Glu Glu Leu Arg Phe Met Lys 
305                 310                 315                 320 


Arg Ile Leu Lys Gly Glu Phe Lys Ala 
                325                 


<210>  21
<211>  326
<212>  PRT
<213>  Thermotoga lettingae

<400>  21

Met Val Tyr Phe Asp Met Pro Leu Glu Asp Leu Arg Lys Tyr Leu Pro 
1               5                   10                  15      


Gln Arg Tyr Glu Glu Lys Asp Phe Asp Asp Phe Trp Lys Gln Thr Ile 
            20                  25                  30          


His Glu Thr Arg Gly Tyr Phe Gln Glu Pro Ile Leu Lys Lys Val Asp 
        35                  40                  45              


Phe Tyr Leu Gln Asn Val Glu Thr Phe Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Lys Ile Lys Gly Trp Leu Ile Leu Pro Lys Phe Arg Asn 
65                  70                  75                  80  


Gly Lys Leu Pro Cys Val Val Glu Phe Val Gly Tyr Gly Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro Tyr Asp Trp Leu Leu Trp Ser Ala Ala Gly Tyr Ala His 
            100                 105                 110         


Phe Ile Met Asp Thr Arg Gly Gln Gly Ser Asn Trp Met Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Glu Asp Asn Pro Ser Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Leu Thr Lys Gly Val Leu Asn Pro Glu Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Met Asp Ala Phe Met Ala Val Glu Thr Ile Ser Gln Leu Glu Gln 
                165                 170                 175     


Ile Asp Ser Gln Thr Ile Ile Leu Ser Gly Ala Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Ser Lys Val Met Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Tyr Lys Arg Ala Val Gln Ile Thr 
    210                 215                 220                 


Asp Ser Met Pro Tyr Ala Glu Ile Thr Arg Tyr Cys Lys Thr His Ile 
225                 230                 235                 240 


Asp Lys Ile Gln Thr Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Cys Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asp Ile Cys Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Glu Lys Asp Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe His Thr Leu Glu Lys Leu Lys Phe Val Lys Lys 
305                 310                 315                 320 


Thr Ile Ser Met Arg Glu 
                325     


<210>  22
<211>  325
<212>  PRT
<213>  Thermotoga petrophilia

<400>  22

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Gly Thr Leu 
            20                  25                  30          


Ala Glu Asn Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Met Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Met Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Asp Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Arg 
                165                 170                 175     


Val Asp His Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Val Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Cys Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Ile Glu Gln Val Lys Phe Leu Lys Arg 
305                 310                 315                 320 


Leu Phe Glu Lys Gly 
                325 


<210>  23
<211>  325
<212>  PRT
<213>  Thermotoga sp. RQ2

<400>  23

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Lys Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Val Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Asp Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Arg 
                165                 170                 175     


Val Asp His Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Val Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Cys Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Ile Glu Gln Val Lys Phe Leu Lys Arg 
305                 310                 315                 320 


Leu Phe Glu Lys Gly 
                325 


<210>  24
<211>  329
<212>  PRT
<213>  Thermotoga sp. RQ2

<400>  24

Met Ala Leu Phe Asp Met Pro Leu Glu Lys Leu Arg Ser Tyr Leu Pro 
1               5                   10                  15      


Asp Arg Tyr Glu Glu Glu Asp Phe Asp Leu Phe Trp Lys Glu Thr Leu 
            20                  25                  30          


Glu Glu Ser Arg Lys Phe Pro Leu Asp Pro Ile Phe Glu Arg Val Asp 
        35                  40                  45              


Tyr Leu Leu Glu Asn Val Glu Val Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Ala Trp Leu Ile Leu Pro Val Val Lys Lys 
65                  70                  75                  80  


Glu Glu Arg Leu Pro Cys Ile Val Glu Phe Ile Gly Tyr Arg Gly Gly 
                85                  90                  95      


Arg Gly Phe Pro Phe Asp Trp Leu Phe Trp Ser Ser Ala Gly Tyr Ala 
            100                 105                 110         


His Phe Val Met Asp Thr Arg Gly Gln Gly Thr Ser Arg Val Lys Gly 
        115                 120                 125             


Asp Thr Pro Asp Tyr Cys Asp Glu Pro Ile Asn Pro Gln Phe Pro Gly 
    130                 135                 140                 


Phe Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg 
145                 150                 155                 160 


Val Phe Thr Asp Ala Val Arg Ala Val Glu Thr Ala Ser Ser Phe Pro 
                165                 170                 175     


Gly Ile Asp Pro Glu Arg Ile Ala Val Val Gly Thr Ser Gln Gly Gly 
            180                 185                 190         


Gly Ile Ala Leu Ala Val Ala Ala Leu Ser Glu Ile Pro Lys Ala Leu 
        195                 200                 205             


Val Ser Asn Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Ile 
    210                 215                 220                 


Thr Asp Asn Ala Pro Tyr Ser Glu Ile Val Asn Tyr Leu Lys Val His 
225                 230                 235                 240 


Arg Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly 
                245                 250                 255     


Val Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Ala 
            260                 265                 270         


Leu Met Asp Lys Thr Cys Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn 
        275                 280                 285             


His Tyr Ala Gly Pro Lys Glu Ile Lys Val Tyr Pro Phe Asn Glu His 
    290                 295                 300                 


Glu Gly Gly Glu Ser Phe Gln Arg Met Glu Glu Leu Arg Phe Met Lys 
305                 310                 315                 320 


Arg Ile Leu Lys Gly Glu Phe Lys Ala 
                325                 


<210>  25
<211>  320
<212>  PRT
<213>  Thermoanaerobacterium saccharolyticum

<400>  25

Met Gly Leu Phe Asp Met Pro Leu Gln Lys Leu Arg Glu Tyr Thr Gly 
1               5                   10                  15      


Thr Asn Pro Cys Pro Glu Asp Phe Asp Glu Tyr Trp Asp Arg Ala Leu 
            20                  25                  30          


Asp Glu Met Arg Ser Val Asp Pro Lys Ile Lys Met Lys Lys Ser Ser 
        35                  40                  45              


Phe Gln Val Pro Phe Ala Glu Cys Tyr Asp Leu Tyr Phe Thr Gly Val 
    50                  55                  60                  


Arg Gly Ala Arg Ile His Ala Lys Tyr Ile Arg Pro Lys Thr Glu Gly 
65                  70                  75                  80  


Lys His Pro Ala Leu Ile Arg Phe His Gly Tyr Ser Ser Asn Ser Gly 
                85                  90                  95      


Asp Trp Asn Asp Lys Leu Asn Tyr Val Ala Ala Gly Phe Thr Val Val 
            100                 105                 110         


Ala Met Asp Ala Arg Gly Gln Gly Gly Gln Ser Gln Asp Val Gly Gly 
        115                 120                 125             


Val Asn Gly Asn Thr Leu Asn Gly His Ile Ile Arg Gly Leu Asp Asp 
    130                 135                 140                 


Asp Ala Asp Asn Met Leu Phe Arg His Ile Phe Leu Asp Thr Ala Gln 
145                 150                 155                 160 


Leu Ala Gly Ile Val Met Asn Met Pro Glu Ile Asp Glu Asp Arg Val 
                165                 170                 175     


Ala Val Met Gly Pro Ser Gln Gly Gly Gly Leu Ser Leu Ala Cys Ala 
            180                 185                 190         


Ala Leu Glu Pro Lys Ile Arg Lys Val Val Ser Glu Tyr Pro Phe Leu 
        195                 200                 205             


Ser Asp Tyr Lys Arg Val Trp Asp Leu Asp Leu Ala Lys Asn Ala Tyr 
    210                 215                 220                 


Gln Glu Ile Thr Asp Tyr Phe Arg Leu Phe Asp Pro Arg His Glu Arg 
225                 230                 235                 240 


Glu Asn Glu Val Phe Thr Lys Leu Gly Tyr Ile Asp Val Lys Asn Leu 
                245                 250                 255     


Ala Lys Arg Ile Lys Gly Asp Val Leu Met Cys Val Gly Leu Met Asp 
            260                 265                 270         


Gln Val Cys Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Asn Ile Gln 
        275                 280                 285             


Ser Lys Lys Asp Ile Lys Val Tyr Pro Asp Tyr Gly His Glu Pro Met 
    290                 295                 300                 


Arg Gly Phe Gly Asp Leu Ala Met Gln Phe Met Leu Glu Leu Tyr Ser 
305                 310                 315                 320 


<210>  26
<211>  312
<212>  PRT
<213>  Lactococcus lactis

<400>  26

Met Thr Lys Ile Asn Asn Trp Gln Asp Tyr Gln Gly Ser Ser Leu Lys 
1               5                   10                  15      


Pro Glu Asp Phe Asp Lys Phe Trp Asp Glu Lys Ile Asn Leu Val Ser 
            20                  25                  30          


Asn His Gln Phe Glu Phe Glu Leu Ile Glu Lys Asn Leu Ser Ser Lys 
        35                  40                  45              


Val Val Asn Phe Tyr His Leu Trp Phe Thr Ala Ile Asp Gly Ala Lys 
    50                  55                  60                  


Ile His Ala Gln Leu Ile Val Pro Lys Asn Leu Lys Glu Lys Tyr Pro 
65                  70                  75                  80  


Ala Ile Leu Gln Phe His Gly Tyr His Cys Asp Ser Gly Asp Trp Val 
                85                  90                  95      


Asp Lys Ile Gly Ile Val Ala Glu Gly Asn Val Val Leu Ala Leu Asp 
            100                 105                 110         


Cys Arg Gly Gln Gly Gly Leu Ser Gln Asp Asn Ile Gln Thr Met Gly 
        115                 120                 125             


Met Thr Met Lys Gly Leu Ile Val Arg Gly Ile Asp Glu Gly Tyr Glu 
    130                 135                 140                 


Asn Leu Tyr Tyr Val Arg Gln Phe Met Asp Leu Ile Thr Ala Thr Lys 
145                 150                 155                 160 


Ile Leu Ser Glu Phe Asp Phe Val Asp Glu Thr Asn Ile Ser Ala Gln 
                165                 170                 175     


Gly Ala Ser Gln Gly Gly Ala Leu Ala Val Ala Cys Ala Ala Leu Ser 
            180                 185                 190         


Pro Leu Ile Lys Lys Val Thr Ala Thr Tyr Pro Phe Leu Ser Asp Tyr 
        195                 200                 205             


Arg Lys Ala Tyr Glu Leu Gly Ala Glu Glu Ser Ala Phe Glu Glu Leu 
    210                 215                 220                 


Pro Tyr Trp Phe Gln Phe Lys Asp Pro Leu His Leu Arg Glu Asp Trp 
225                 230                 235                 240 


Phe Phe Asn Gln Leu Glu Tyr Ile Asp Ile Gln Asn Leu Ala Pro Arg 
                245                 250                 255     


Ile Lys Ala Glu Val Ile Trp Ile Leu Gly Gly Lys Asp Thr Val Val 
            260                 265                 270         


Pro Pro Ile Thr Gln Met Ala Ala Tyr Asn Lys Ile Gln Ser Lys Lys 
        275                 280                 285             


Ser Leu Tyr Val Leu Pro Glu Tyr Gly His Glu Tyr Leu Pro Lys Ile 
    290                 295                 300                 


Ser Asp Trp Leu Arg Glu Asn Gln 
305                 310         


<210>  27
<211>  323
<212>  PRT
<213>  Mesorhizobium loit

<400>  27

Met Pro Phe Pro Asp Leu Ile Gln Pro Glu Leu Gly Ala Tyr Val Ser 
1               5                   10                  15      


Ser Val Gly Met Pro Asp Asp Phe Ala Gln Phe Trp Thr Ser Thr Ile 
            20                  25                  30          


Ala Glu Ala Arg Gln Ala Gly Gly Glu Val Ser Ile Val Gln Ala Gln 
        35                  40                  45              


Thr Thr Leu Lys Ala Val Gln Ser Phe Asp Val Thr Phe Pro Gly Tyr 
    50                  55                  60                  


Gly Gly His Pro Ile Lys Gly Trp Leu Ile Leu Pro Thr His His Lys 
65                  70                  75                  80  


Gly Arg Leu Pro Leu Val Val Gln Tyr Ile Gly Tyr Gly Gly Gly Arg 
                85                  90                  95      


Gly Leu Ala His Glu Gln Leu His Trp Ala Ala Ser Gly Phe Ala Tyr 
            100                 105                 110         


Phe Arg Met Asp Thr Arg Gly Gln Gly Ser Asp Trp Ser Val Gly Glu 
        115                 120                 125             


Thr Ala Asp Pro Val Gly Ser Thr Ser Ser Ile Pro Gly Phe Met Thr 
    130                 135                 140                 


Arg Gly Val Leu Asp Lys Asn Asp Tyr Tyr Tyr Arg Arg Leu Phe Thr 
145                 150                 155                 160 


Asp Ala Val Arg Ala Ile Asp Ala Leu Leu Gly Leu Asp Phe Val Asp 
                165                 170                 175     


Pro Glu Arg Ile Ala Val Cys Gly Asp Ser Gln Gly Gly Gly Ile Ser 
            180                 185                 190         


Leu Ala Val Gly Gly Ile Asp Pro Arg Val Lys Ala Val Met Pro Asp 
        195                 200                 205             


Val Pro Phe Leu Cys Asp Phe Pro Arg Ala Val Gln Thr Ala Val Arg 
    210                 215                 220                 


Asp Pro Tyr Leu Glu Ile Val Arg Phe Leu Ala Gln His Arg Glu Lys 
225                 230                 235                 240 


Lys Ala Ala Val Phe Glu Thr Leu Asn Tyr Phe Asp Cys Val Asn Phe 
                245                 250                 255     


Ala Arg Arg Ser Lys Ala Pro Ala Leu Phe Ser Val Ala Leu Met Asp 
            260                 265                 270         


Glu Val Cys Pro Pro Ser Thr Val Tyr Gly Ala Phe Asn Ala Tyr Ala 
        275                 280                 285             


Gly Glu Lys Thr Ile Thr Glu Tyr Glu Phe Asn Asn His Glu Gly Gly 
    290                 295                 300                 


Gln Gly Tyr Gln Glu Arg Gln Gln Met Thr Trp Leu Ser Arg Leu Phe 
305                 310                 315                 320 


Gly Val Gly 
            


<210>  28
<211>  329
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  28

Met Phe Asp Met Pro Leu Ala Gln Leu Gln Lys Tyr Met Gly Thr Asn 
1               5                   10                  15      


Pro Lys Pro Ala Asp Phe Ala Asp Phe Trp Ser Arg Ala Leu Glu Glu 
            20                  25                  30          


Leu Ser Ala Gln Ser Leu His Tyr Glu Leu Ile Pro Ala Thr Phe Gln 
        35                  40                  45              


Thr Thr Val Ala Ser Cys Tyr His Leu Tyr Phe Thr Gly Val Gly Gly 
    50                  55                  60                  


Ala Arg Val His Cys Gln Leu Val Lys Pro Arg Glu Gln Lys Gln Lys 
65                  70                  75                  80  


Gly Pro Gly Leu Val Trp Phe His Gly Tyr His Thr Asn Ser Gly Asp 
                85                  90                  95      


Trp Val Asp Lys Leu Ala Tyr Ala Ala Ala Gly Phe Thr Val Leu Ala 
            100                 105                 110         


Met Asp Cys Arg Gly Gln Gly Gly Lys Ser Glu Asp Asn Leu Gln Val 
        115                 120                 125             


Lys Gly Pro Thr Leu Lys Gly His Ile Ile Arg Gly Ile Glu Asp Pro 
    130                 135                 140                 


Asn Pro His His Leu Tyr Tyr Arg Asn Val Phe Leu Asp Thr Val Gln 
145                 150                 155                 160 


Ala Val Arg Ile Leu Cys Ser Met Asp His Ile Asp Arg Glu Arg Ile 
                165                 170                 175     


Gly Val Tyr Gly Ala Ser Gln Gly Gly Ala Leu Ala Leu Ala Cys Ala 
            180                 185                 190         


Ala Leu Glu Pro Ser Val Val Lys Lys Ala Val Val Leu Tyr Pro Phe 
        195                 200                 205             


Leu Ser Asp Tyr Lys Arg Ala Gln Glu Leu Asp Met Lys Asn Thr Ala 
    210                 215                 220                 


Tyr Glu Glu Ile His Tyr Tyr Phe Arg Phe Leu Asp Pro Thr His Glu 
225                 230                 235                 240 


Arg Glu Glu Glu Val Phe Tyr Lys Leu Gly Tyr Ile Asp Ile Gln Leu 
                245                 250                 255     


Leu Ala Asp Arg Ile Cys Ala Asp Val Leu Trp Ala Val Ala Leu Glu 
            260                 265                 270         


Asp His Ile Cys Pro Pro Ser Thr Gln Phe Ala Val Tyr Asn Lys Ile 
        275                 280                 285             


Lys Ser Lys Lys Asp Met Val Leu Phe Tyr Glu Tyr Gly His Glu Tyr 
    290                 295                 300                 


Leu Pro Thr Met Gly Asp Arg Ala Tyr Leu Phe Phe Cys Pro Ile Phe 
305                 310                 315                 320 


Phe Pro Ile Gln Lys Arg Asn Val Lys 
                325                 


<210>  29
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  29

Ala His Pro Glu Ser Leu Gly Ile Lys Tyr Ala Leu Asp Gly Asn Ser 
1               5                   10                  15      


Asp Pro His Ala 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  30

Ala Ser Val Ser Asn Tyr Pro Pro Ile His His Leu Ala Thr Ser Asn 
1               5                   10                  15      


Thr Thr Val Asn 
            20  


<210>  31
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  31

Asp Glu Cys Met Glu Pro Leu Asn Ala Ala His Cys Trp Arg 
1               5                   10                  


<210>  32
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  32

Asp Glu Cys Met His Gly Ser Asp Val Glu Phe Cys Thr Ser 
1               5                   10                  


<210>  33
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  33

Asp Leu Cys Ser Met Gln Met Met Asn Thr Gly Cys His Tyr 
1               5                   10                  


<210>  34
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  34

Asp Leu Cys Ser Ser Pro Ser Thr Trp Gly Ser Cys Ile Arg 
1               5                   10                  


<210>  35
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  35

Asp Pro Asn Glu Ser Asn Tyr Glu Asn Ala Thr Thr Val Ser Gln Pro 
1               5                   10                  15      


Thr Arg His Leu 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  36

Glu Pro Thr His Pro Thr Met Arg Ala Gln Met His Gln Ser Leu Arg 
1               5                   10                  15      


Ser Ser Ser Pro 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  37

Gly Asn Thr Asp Thr Thr Pro Pro Asn Ala Val Met Glu Pro Thr Val 
1               5                   10                  15      


Gln His Lys Trp 
            20  


<210>  38
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  38

Asn Gly Pro Asp Met Val Gln Ser Val Gly Lys His Lys Asn Ser 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  39

Asn Gly Pro Glu Val Arg Gln Ile Pro Ala Asn Phe Glu Lys Leu 
1               5                   10                  15  


<210>  40
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  40

Asn Asn Thr Ser Ala Asp Asn Pro Pro Glu Thr Asp Ser Lys His His 
1               5                   10                  15      


Leu Ser Met Ser 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  41

Asn Asn Thr Trp Pro Glu Gly Ala Gly His Thr Met Pro Ser Thr Asn 
1               5                   10                  15      


Ile Arg Gln Ala 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  42

Asn Pro Thr Ala Thr Pro His Met Lys Asp Pro Met His Ser Asn Ala 
1               5                   10                  15      


His Ser Ser Ala 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  43

Asn Pro Thr Asp His Ile Pro Ala Asn Ser Thr Asn Ser Arg Val Ser 
1               5                   10                  15      


Lys Gly Asn Thr 
            20  


<210>  44
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  44

Asn Pro Thr Asp Ser Thr His Met Met His Ala Arg Asn His Glu 
1               5                   10                  15  


<210>  45
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  45

Gln His Cys Ile Thr Glu Arg Leu His Pro Pro Cys Thr Lys 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  46

Thr Pro Cys Ala Pro Ala Ser Phe Asn Pro His Cys Ser Arg 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  47

Thr Pro Cys Ala Thr Tyr Pro His Phe Ser Gly Cys Arg Ala 
1               5                   10                  


<210>  48
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  48

Trp Cys Thr Asp Phe Cys Thr Arg Ser Thr Pro Thr Ser Thr Ser Arg 
1               5                   10                  15      


Ser Thr Thr Ser 
            20  


<210>  49
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  49

Ala Pro Pro Leu Lys Thr Tyr Met Gln Glu Arg Glu Leu Thr Met Ser 
1               5                   10                  15      


Gln Asn Lys Asp 
            20  


<210>  50
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  50

Glu Pro Pro Thr Arg Thr Arg Val Asn Asn His Thr Val Thr Val Gln 
1               5                   10                  15      


Ala Gln Gln His 
            20  


<210>  51
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  51

Gly Tyr Cys Leu Arg Gly Asp Glu Pro Ala Val Cys Ser Gly 
1               5                   10                  


<210>  52
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  52

Leu Ser Ser Lys Asp Phe Gly Val Thr Asn Thr Asp Gln Arg Thr Tyr 
1               5                   10                  15      


Asp Tyr Thr Thr 
            20  


<210>  53
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  53

Asn Phe Cys Glu Thr Gln Leu Asp Leu Ser Val Cys Thr Val 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  54

Asn Thr Cys Gln Pro Thr Lys Asn Ala Thr Pro Cys Ser Ala 
1               5                   10                  


<210>  55
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  55

Pro Ser Glu Pro Glu Arg Arg Asp Arg Asn Ile Ala Ala Asn Ala Gly 
1               5                   10                  15      


Arg Phe Asn Thr 
            20  


<210>  56
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  56

Thr His Asn Met Ser His Phe Pro Pro Ser Gly His Pro Lys Arg Thr 
1               5                   10                  15      


Ala Thr 
        


<210>  57
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  57

Thr Thr Cys Pro Thr Met Gly Thr Tyr His Val Cys Trp Leu 
1               5                   10                  


<210>  58
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  58

Tyr Cys Ala Asp His Thr Pro Asp Pro Ala Asn Pro Asn Lys Ile Cys 
1               5                   10                  15      


Gly Tyr Ser His 
            20  


<210>  59
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  59

Ala Ala Asn Pro His Thr Glu Trp Asp Arg Asp Ala Phe Gln Leu Ala 
1               5                   10                  15      


Met Pro Pro Lys 
            20  


<210>  60
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  60

Asp Leu His Pro Met Asp Pro Ser Asn Lys Arg Pro Asp Asn Pro Ser 
1               5                   10                  15      


Asp Leu His Thr 
            20  


<210>  61
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  61

Glu Ser Cys Val Ser Asn Ala Leu Met Asn Gln Cys Ile Tyr 
1               5                   10                  


<210>  62
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  62

His Asn Lys Ala Asp Ser Trp Asp Pro Asp Leu Pro Pro His Ala Gly 
1               5                   10                  15      


Met Ser Leu Gly 
            20  


<210>  63
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  63

Leu Asn Asp Gln Arg Lys Pro Gly Pro Pro Thr Met Pro Thr His Ser 
1               5                   10                  15      


Pro Ala Val Gly 
            20  


<210>  64
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  64

Asn Thr Cys Ala Thr Ser Pro Asn Ser Tyr Thr Cys Ser Asn 
1               5                   10                  


<210>  65
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  65

Ser Asp Cys Thr Ala Gly Leu Val Pro Pro Leu Cys Ala Thr 
1               5                   10                  


<210>  66
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  66

Thr Ile Glu Ser Ser Gln His Ser Arg Thr His Gln Gln Asn Tyr Gly 
1               5                   10                  15      


Ser Thr Lys Thr 
            20  


<210>  67
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  67

Val Gly Thr Met Lys Gln His Pro Thr Thr Thr Gln Pro Pro Arg Val 
1               5                   10                  15      


Ser Ala Thr Asn 
            20  


<210>  68
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic construct

<400>  68

Tyr Ser Glu Thr Pro Asn Asp Gln Lys Pro Asn Pro His Tyr Lys Val 
1               5                   10                  15      


Ser Gly Thr Lys 
            20  


<210>  69
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  69

Asn Gly Asn Asn His Thr Asp Ile Pro Asn Arg Ser Ser Tyr Thr Gly 
1               5                   10                  15      


Gly Ser Phe Ala 
            20  


<210>  70
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  70

Thr Met Thr Asn His Val Tyr Asn Ser Tyr Thr Glu Lys His Ser Ser 
1               5                   10                  15      


Thr His Arg Ser 
            20  


<210>  71
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  71

Thr Thr Tyr His Tyr Lys Asn Ile Tyr Gln Glu Ser Tyr Gln Gln Arg 
1               5                   10                  15      


Asn Pro Ala Val 
            20  


<210>  72
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  72

Val Glu Pro Ala Thr Lys Asn Met Arg Glu Ala Arg Ser Ser Thr Gln 
1               5                   10                  15      


Met Arg Arg Ile 
            20  


<210>  73
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  73

Tyr Leu Leu Pro Lys Asp Gln Thr Thr Ala Pro Gln Val Thr Pro Ile 
1               5                   10                  15      


Val Gln His Lys 
            20  


<210>  74
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  74

Ala Ser Asn Leu Asp Ser Thr Phe Thr Ala Ile Asn Thr Pro Ala Cys 
1               5                   10                  15      


Cys Thr 
        


<210>  75
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  75

Glu Phe Pro Tyr Tyr Asn Asp Asn Pro Pro Asn Pro Glu Arg His Thr 
1               5                   10                  15      


Leu Arg 
        


<210>  76
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  76

Gly Met Pro Thr Arg Tyr Tyr His Asn Thr Pro Pro His Leu Thr Pro 
1               5                   10                  15      


Lys Phe 
        


<210>  77
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  77

His Lys Asn Ala Ile Gln Pro Val Asn Asp Ala Thr Thr Leu Asp Thr 
1               5                   10                  15      


Thr Met 
        


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  78

Ala Val Val Pro Ala Asp Leu Asn Asp His Ala Asn His Leu Ser 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  79

Asp Leu Gly Thr Phe Pro Asn Arg Thr Leu Lys Met Ala Ala His 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  80

Phe Asp Gly Ile Gly Leu Gly Thr Ala Thr Arg His Gln Asn Arg 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  81

Gln Ala Ala Gln Val His Met Met Gln His Ser Arg Pro Thr Thr 
1               5                   10                  15  


<210>  82
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  82

Ser Glu Ala Arg Ala Arg Thr Phe Asn Asp His Thr Thr Pro Met Pro 
1               5                   10                  15      


Ile Ile 
        


<210>  83
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  83

Glu Leu Asp His Asp Ser Arg His Tyr Met Asn Gly Leu Gln Arg Lys 
1               5                   10                  15      


Val Thr 
        


<210>  84
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  84

Gly Pro Gln His Val Leu Met Gln Asp Thr His Gln Gly Tyr Ala Phe 
1               5                   10                  15      


Asp Asn 
        


<210>  85
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  85

Thr Thr Gly Ser Ser Ser Gln Ala Asp Thr Ser Ala Ser Met Ser Ile 
1               5                   10                  15      


Val Pro Ala His 
            20  


<210>  86
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  86

Lys Ala Pro Ile Ala Asn Met Leu Gln Pro His Ser Tyr Gln Tyr Ser 
1               5                   10                  15      


Val Ala 
        


<210>  87
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  87

Thr Tyr Gln Gly Val Pro Ser Trp Pro Ala Val Ile Asp Asp Ala Ile 
1               5                   10                  15      


Arg Arg 
        


<210>  88
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  88

Val Asn Pro Asn Trp Val Glu Thr Gln Ala Leu His Gln Pro Pro Gly 
1               5                   10                  15      


Asn Thr 
        


<210>  89
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  89

Asp His Asn Asn Arg Gln His Ala Val Glu Val Arg Glu Asn Lys Thr 
1               5                   10                  15      


His Thr Ala Arg 
            20  


<210>  90
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  90

Ile Tyr Pro Asn Glu Ser Met Ser Thr Ser Asn Val Arg Gly Pro Tyr 
1               5                   10                  15      


His Pro 
        


<210>  91
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  91

His Asp Pro Asn His Leu Thr His Gln Ala Arg Thr Ile Tyr Arg Asn 
1               5                   10                  15      


Ala Asn His Thr 
            20  


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  92

Ser Asn Ala Thr Met Tyr Asn Ile Gln Ser His Ser His His Gln 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  93

Ala Asn Glu Leu Ser Thr Tyr Ala Gln Thr Asn Pro Gly Ser Gly 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  94

Asp Thr Ile His Pro Asn Lys Met Lys Ser Pro Ser Ser Pro Leu 
1               5                   10                  15  


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  95

Ala Pro Pro Thr Tyr Gln Thr Ala Ser Tyr Pro His Asn Leu Pro Ser 
1               5                   10                  15      


Lys Arg Lys Met 
            20  


<210>  96
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  96

Gln Val Pro Asp Tyr Leu Ser Pro Thr His Gln Lys Lys Ala Phe Leu 
1               5                   10                  15      


Glu Ile Pro Thr 
            20  


<210>  97
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  97

Thr Asn Asp Leu His Ala Asn Pro Phe Thr Gly Thr Tyr Ile Ala Pro 
1               5                   10                  15      


Asp Pro Thr Ser 
            20  


<210>  98
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  98

His Lys Asn Glu Asn Ile Met Gln Tyr Asn Val Asn Asp Arg Trp His 
1               5                   10                  15      


Ile Thr Pro Ala 
            20  


<210>  99
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  99

Ile Asp Gly Pro His His Ser Pro Val His Arg Tyr His Thr Pro Ser 
1               5                   10                  15      


Ile Thr 
        


<210>  100
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  100

Ala Ile Glu Tyr Gln His Ser Ala Thr Thr Pro Trp Thr Met Arg Thr 
1               5                   10                  15      


Arg Leu Pro Pro 
            20  


<210>  101
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  101

Glu Phe Tyr Pro Phe Ala Glu Val Pro Pro Glu Lys Ser Gly Ile Gly 
1               5                   10                  15      


Arg Gln Val Phe 
            20  


<210>  102
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  102

Gly Val His Gln Tyr Ser Arg Pro Thr Val Pro Ser Tyr Leu Trp Thr 
1               5                   10                  15      


Ser Gly Gln His 
            20  


<210>  103
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  103

Gly Tyr Gln Pro His Tyr Val Asp His Thr Ile Gly Trp Gln Pro Met 
1               5                   10                  15      


Ile Arg Pro Asn 
            20  


<210>  104
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  104

Gln Phe Asn Gln Thr Ser His Ser Phe Met His Gly Thr Ser Gly Tyr 
1               5                   10                  15      


Val Pro Gly Lys 
            20  


<210>  105
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  105

Ser Phe Ser Trp His Arg Gly Asp Trp Glu Leu Gly His Gln Ser Lys 
1               5                   10                  15      


Thr Met Gly Met 
            20  


<210>  106
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  106

Ser Met Trp His Asp Ile Thr Lys Arg Tyr Arg Asn Pro Ser Glu Met 
1               5                   10                  15      


Val Ser Ala Tyr 
            20  


<210>  107
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  107

Thr His Gly Asn Lys His Gln Ser Trp Thr Tyr Pro Ser Glu Ile Asn 
1               5                   10                  15      


His Lys Asn Tyr 
            20  


<210>  108
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  108

Trp His Glu Pro His Gln Phe Ser Gly Glu Asn Thr Asp Tyr Ser Ser 
1               5                   10                  15      


Ser Met Gly Thr 
            20  


<210>  109
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  109

Thr His Gly Asn Lys His Gln Ser Trp Thr Tyr Pro Ser Glu Ile Asn 
1               5                   10                  15      


His Lys Asn Tyr 
            20  


<210>  110
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  110

Asp Gly Tyr Lys Leu Gln Thr Ser Leu Asp Trp Gln Met Trp Asn Pro 
1               5                   10                  15      


<210>  111
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  111

Phe Pro Ser Lys Trp Tyr Asn His His Arg His Ile Thr Gly His Val 
1               5                   10                  15      


<210>  112
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  112

Gly Gly Met Gly Ala Leu Glu Ser Tyr Arg Gln Trp Asn His Leu Ala 
1               5                   10                  15      


<210>  113
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  113

Gly Ile Asn Lys Gly Gln Arg Pro Pro Trp Glu Ser Trp His Glu Asn 
1               5                   10                  15      


<210>  114
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  114

Gly Tyr Gly Gln Tyr Val Ser Gln Gln Thr Trp Ala His Ser Asn Lys 
1               5                   10                  15      


<210>  115
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  115

His Asp His Leu Ser Trp Trp Gly Gln Phe Asp Arg Gln Asn Leu Leu 
1               5                   10                  15      


<210>  116
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  116

Met Pro Gly His Gln Glu Ser Ile Lys Val Gln Asn Trp Asn Arg Val 
1               5                   10                  15      


<210>  117
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  117

Asn Leu His Ser Pro Trp Pro Ser His Ala Ala His His Trp Ser Thr 
1               5                   10                  15      


<210>  118
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  118

Asn Gln Gln Met Lys Leu Val Pro Gln His Trp His Arg Ala Gln Pro 
1               5                   10                  15      


<210>  119
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oral-surface binding peptide

<400>  119

Ser Glu Lys Trp Phe Asn Pro Gly Pro Trp Pro Lys Leu Ala Thr Gln 
1               5                   10                  15      


<210>  120
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  120

Ser Ser Arg Pro Asn Gly Asn Asn His Thr Asp Ile Pro Asn Arg Ser 
1               5                   10                  15      


Ser Tyr Thr Gly Gly Ser Phe Ala Lys 
            20                  25  


<210>  121
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  121

Ser Ser Arg Pro Thr Met Thr Asn His Val Tyr Asn Ser Tyr Thr Glu 
1               5                   10                  15      


Lys His Ser Ser Thr His Arg Ser Lys 
            20                  25  


<210>  122
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  122

Ser Ser Arg Pro Thr Thr Tyr His Tyr Lys Asn Ile Tyr Gln Glu Ser 
1               5                   10                  15      


Tyr Gln Gln Arg Asn Pro Ala Val Lys 
            20                  25  


<210>  123
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  123

Ser Ser Arg Pro Val Glu Pro Ala Thr Lys Asn Met Arg Glu Ala Arg 
1               5                   10                  15      


Ser Ser Thr Gln Met Arg Arg Ile Lys 
            20                  25  


<210>  124
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  124

Ser Ser Arg Pro Tyr Leu Leu Pro Lys Asp Gln Thr Thr Ala Pro Gln 
1               5                   10                  15      


Val Thr Pro Ile Val Gln His Lys Lys 
            20                  25  


<210>  125
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  125

Ser Ser Arg Pro Glu Phe Pro Tyr Tyr Asn Asp Asn Pro Pro Asn Pro 
1               5                   10                  15      


Glu Arg His Thr Leu Arg Lys 
            20              


<210>  126
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  126

Ser Ser Arg Pro Asp Leu Gly Thr Phe Pro Asn Arg Thr Leu Lys Met 
1               5                   10                  15      


Ala Ala His Lys 
            20  


<210>  127
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  127

Ser Ser Arg Pro Phe Asp Gly Ile Gly Leu Gly Thr Ala Thr Arg His 
1               5                   10                  15      


Gln Asn Arg Lys 
            20  


<210>  128
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  128

Ser Ser Arg Pro Gln Ala Ala Gln Val His Met Met Gln His Ser Arg 
1               5                   10                  15      


Pro Thr Thr Lys 
            20  


<210>  129
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  129

Ser Ser Arg Pro Ser Glu Ala Arg Ala Arg Thr Phe Asn Asp His Thr 
1               5                   10                  15      


Thr Pro Met Pro Ile Ile Lys 
            20              


<210>  130
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  130

Ser Ser Arg Pro Glu Leu Asp His Asp Ser Arg His Tyr Met Asn Gly 
1               5                   10                  15      


Leu Gln Arg Lys Val Thr Lys 
            20              


<210>  131
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  131

Ser Ser Arg Pro Gly Pro Gln His Val Leu Met Gln Asp Thr His Gln 
1               5                   10                  15      


Gly Tyr Ala Phe Asp Asn Lys 
            20              


<210>  132
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  132

Ser Ser Arg Pro Thr Thr Gly Ser Ser Ser Gln Ala Asp Thr Ser Ala 
1               5                   10                  15      


Ser Met Ser Ile Val Pro Ala His Lys 
            20                  25  


<210>  133
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  133

Ser Ser Arg Pro Thr Tyr Gln Gly Val Pro Ser Trp Pro Ala Val Ile 
1               5                   10                  15      


Asp Asp Ala Ile Arg Arg Lys 
            20              


<210>  134
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  134

Ser Ser Arg Pro Val Asn Pro Asn Trp Val Glu Thr Gln Ala Leu His 
1               5                   10                  15      


Gln Pro Pro Gly Asn Thr Lys 
            20              


<210>  135
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  135

Ser Ser Arg Pro Ile Tyr Pro Asn Glu Ser Met Ser Thr Ser Asn Val 
1               5                   10                  15      


Arg Gly Pro Tyr His Pro Lys 
            20              


<210>  136
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  136

Ser Ser Arg Pro His Asp Pro Asn His Leu Thr His Gln Ala Arg Thr 
1               5                   10                  15      


Ile Tyr Arg Asn Ala Asn His Thr Lys 
            20                  25  


<210>  137
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  137

Ser Ser Arg Pro Ala Pro Pro Thr Tyr Gln Thr Ala Ser Tyr Pro His 
1               5                   10                  15      


Asn Leu Pro Ser Lys Arg Lys Met Lys 
            20                  25  


<210>  138
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  138

Ser Ser Arg Pro Gln Val Pro Asp Tyr Leu Ser Pro Thr His Gln Lys 
1               5                   10                  15      


Lys Ala Phe Leu Glu Ile Pro Thr Lys 
            20                  25  


<210>  139
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  139

Ser Ser Arg Pro His Lys Asn Glu Asn Ile Met Gln Tyr Asn Val Asn 
1               5                   10                  15      


Asp Arg Trp His Ile Thr Pro Ala Lys 
            20                  25  


<210>  140
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  140

Ser Asn Ala Thr Met Tyr Asn Ile Gln Ser His Ser His His Gln 
1               5                   10                  15  


<210>  141
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  141

Gln Ala Ala Gln Val His Met Met Gln His Ser Arg Pro Thr Thr 
1               5                   10                  15  


<210>  142
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  142

His Asp Pro Tyr Thr Met Lys Ser Ala Leu Arg Gln Ser Thr Ser 
1               5                   10                  15  


<210>  143
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  143

Asp Leu Gly Thr Phe Pro Asn Arg Thr Leu Lys Met Ala Ala His 
1               5                   10                  15  


<210>  144
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  144

Asp Thr Ile His Pro Asn Lys Met Lys Ser Pro Ser Ser Pro Leu 
1               5                   10                  15  


<210>  145
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  145

Gly Ser Asn Asn His Leu Pro Ser Thr Val Pro Arg Leu Thr Val 
1               5                   10                  15  


<210>  146
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  146

Ser Asn Pro Ile Pro Asn Phe Ala His Asp Leu Arg His Ser Lys Tyr 
1               5                   10                  15      


Asn Ser 
        


<210>  147
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  147

Thr Lys Pro Pro Arg Thr Pro Thr Ala Asn Thr Ser Arg Pro His His 
1               5                   10                  15      


Asn Phe 
        


<210>  148
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  148

Ala Asn Ser Gly Phe Pro Ile Trp Leu Gln Lys Tyr Pro Trp Ser Glu 
1               5                   10                  15      


Val Gln Gln Glu 
            20  


<210>  149
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  149

Ala Thr Pro Arg Leu Thr Pro Glu Ala His His Lys Ala Gly Asn Trp 
1               5                   10                  15      


Tyr Ala Ser 
            


<210>  150
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  150

Ala Thr Pro Ser Gln His Arg Tyr Gly Leu Met Gln Asn His Ala Pro 
1               5                   10                  15      


Asn Gly Ile Glu 
            20  


<210>  151
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  151

Gly Met Gly Ser Glu Val Leu Ser Gln Tyr Pro Gln Ala Pro Val Gly 
1               5                   10                  15      


<210>  152
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  152

Thr Thr Tyr His Tyr Lys Asn Ile Tyr Gln Glu Ser Tyr Gln Gln Arg 
1               5                   10                  15      


Asn Pro Ala Val Lys 
            20      


<210>  153
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  153

Ser Asn Ala Thr Met Tyr Asn Ile Gln Ser His Ser His His Gln Lys 
1               5                   10                  15      


<210>  154
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  154

Gln Ala Ala Gln Val His Met Met Gln His Ser Arg Pro Thr Thr Lys 
1               5                   10                  15      


<210>  155
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  155

His Asp Pro Tyr Thr Met Lys Ser Ala Leu Arg Gln Ser Thr Ser Lys 
1               5                   10                  15      


<210>  156
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  156

Asp Leu Gly Thr Phe Pro Asn Arg Thr Leu Lys Met Ala Ala His Lys 
1               5                   10                  15      


<210>  157
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  157

Asp Thr Ile His Pro Asn Lys Met Lys Ser Pro Ser Ser Pro Leu Lys 
1               5                   10                  15      


<210>  158
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  158

Gly Ser Asn Asn His Leu Pro Ser Thr Val Pro Arg Leu Thr Val Lys 
1               5                   10                  15      


<210>  159
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  159

Ser Asn Pro Ile Pro Asn Phe Ala His Asp Leu Arg His Ser Lys Tyr 
1               5                   10                  15      


Asn Ser Lys 
            


<210>  160
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  160

Thr Lys Pro Pro Arg Thr Pro Thr Ala Asn Thr Ser Arg Pro His His 
1               5                   10                  15      


Asn Phe Lys 
            


<210>  161
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  161

Ala Asn Ser Gly Phe Pro Ile Trp Leu Gln Lys Tyr Pro Trp Ser Glu 
1               5                   10                  15      


Val Gln Gln Glu Lys 
            20      


<210>  162
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  162

Ala Thr Pro Ser Gln His Arg Tyr Gly Leu Met Gln Asn His Ala Pro 
1               5                   10                  15      


Asn Gly Ile Glu Lys 
            20      


<210>  163
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  163

Gly Met Gly Ser Glu Val Leu Ser Gln Tyr Pro Gln Ala Pro Val Gly 
1               5                   10                  15      


Lys 
    


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct - caspace 3 cleavable linker

<400>  164

Leu Glu Ser Gly Asp Glu Val Asp 
1               5               


<210>  165
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  165

Thr Ser Thr Ser Lys Ala Ser Thr Thr Thr Thr Ser Ser Lys Thr Thr 
1               5                   10                  15      


Thr Thr Ser Ser Lys Thr Thr Thr Thr Thr Ser Lys Thr Ser Thr Thr 
            20                  25                  30          


Ser Ser Ser Ser Thr 
        35          


<210>  166
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  166

Gly Gln Gly Gly Tyr Gly Gly Leu Gly Ser Gln Gly Ala Gly Arg Gly 
1               5                   10                  15      


Gly Leu Gly Gly Gln Gly 
            20          


<210>  167
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  167

Gly Pro Gly Gly Tyr Gly Pro Gly Gln Gln 
1               5                   10  


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  168

Gly Gly Ser Gly Pro Gly Ser Gly Gly 
1               5                   


<210>  169
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  169

Gly Gly Pro Lys Lys 
1               5   


<210>  170
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  170

Gly Pro Gly Val Gly 
1               5   


<210>  171
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  171

Gly Gly Gly Cys Gly Gly Gly 
1               5           


<210>  172
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  172

Gly Gly Gly Cys 
1               


<210>  173
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  173

Pro His Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Ser 
1               5                   10                  


<210>  174
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  174

Gly Pro Glu Glu Ala Ala Lys Lys Glu Glu Ala Ala Lys Lys Pro Ala 
1               5                   10                  15      


<210>  175
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  175

Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  


<210>  176
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  176

Gly Pro Glu Pro Glu Pro Glu Pro Glu Pro Ile Pro Glu Pro Pro Lys 
1               5                   10                  15      


Glu Ala Pro Val Val Ile Glu Lys Pro Lys Pro Lys Pro Lys Pro Lys 
            20                  25                  30          


Pro Lys Pro Pro Ala 
        35          


<210>  177
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  177

Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly Ser Ala Gly Gly Pro 
1               5                   10                  15      


Gly Ser 
        


<210>  178
<211>  431
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  178

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly 
                325                 330                 335     


Ser Ala Gly Gly Pro Gly Ser Pro Ser Ala Gln Ser Gln Leu Pro Asp 
            340                 345                 350         


Lys His Ser Gly Leu His Glu Arg Ala Pro Gln Arg Tyr Gly Pro Glu 
        355                 360                 365             


Pro Glu Pro Glu Pro Glu Pro Ile Pro Glu Pro Pro Lys Glu Ala Pro 
    370                 375                 380                 


Val Val Ile Glu Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro 
385                 390                 395                 400 


Pro Ala His Asp His Lys Asn Gln Lys Glu Thr His Gln Arg His Ala 
                405                 410                 415     


Ala Gly Ser Gly Gly Gly Gly Ser Pro His His His His His His 
            420                 425                 430     


<210>  179
<211>  353
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  179

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly 
                325                 330                 335     


Ser Ala Gly Gly Pro Gly Ser Gly Lys Gly Lys Gly Lys Gly Lys Gly 
            340                 345                 350         


Lys 
    


<210>  180
<211>  359
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  180

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly 
                325                 330                 335     


Ser Ala Gly Gly Pro Gly Ser Gly Lys Gly Lys Gly Lys Gly Lys Gly 
            340                 345                 350         


Lys His His His His His His 
        355                 


<210>  181
<211>  375
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  181

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Thr Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly 
                325                 330                 335     


Ser Ala Gly Gly Pro Gly Ser Thr Lys Pro Pro Arg Thr Pro Thr Ala 
            340                 345                 350         


Asn Thr Ser Arg Pro His His Asn Phe Gly Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Pro His His His His His His 
    370                 375 


<210>  182
<211>  431
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  182

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Thr Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly 
                325                 330                 335     


Ser Ala Gly Gly Pro Gly Ser Pro Ser Ala Gln Ser Gln Leu Pro Asp 
            340                 345                 350         


Lys His Ser Gly Leu His Glu Arg Ala Pro Gln Arg Tyr Gly Pro Glu 
        355                 360                 365             


Pro Glu Pro Glu Pro Glu Pro Ile Pro Glu Pro Pro Lys Glu Ala Pro 
    370                 375                 380                 


Val Val Ile Glu Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro 
385                 390                 395                 400 


Pro Ala His Asp His Lys Asn Gln Lys Glu Thr His Gln Arg His Ala 
                405                 410                 415     


Ala Gly Ser Gly Gly Gly Gly Ser Pro His His His His His His 
            420                 425                 430     


<210>  183
<211>  359
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  183

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Thr Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly 
                325                 330                 335     


Ser Ala Gly Gly Pro Gly Ser Gly Lys Gly Lys Gly Lys Gly Lys Gly 
            340                 345                 350         


Lys His His His His His His 
        355                 


<210>  184
<211>  386
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  184

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Glu Pro Glu Pro Glu Gly Pro Gly Ser Gly Gly 
                325                 330                 335     


Ala Gly Ser Pro Gly Ser Ala Gly Gly Pro Gly Ser Glu Pro Glu Pro 
            340                 345                 350         


Glu Trp Lys Thr Lys Lys Ile Leu Leu Ser Arg Thr Arg Arg Ile Met 
        355                 360                 365             


Arg Gln Val Val Arg Ser Val Met His Lys Ile Trp His His His His 
    370                 375                 380                 


His His 
385     


<210>  185
<211>  387
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  185

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
                325                 330                 335     


Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly Ser Ala Gly Gly Pro 
            340                 345                 350         


Gly Ser Trp Lys Thr Lys Lys Ile Leu Leu Ser Arg Thr Arg Arg Ile 
        355                 360                 365             


Met Arg Gln Val Val Arg Ser Val Met His Lys Ile Trp His His His 
    370                 375                 380                 


His His His 
385         


<210>  186
<211>  386
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  186

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Glu Pro Glu Pro Glu Gly Pro Gly Ser Gly Gly 
                325                 330                 335     


Ala Gly Ser Pro Gly Ser Ala Gly Gly Pro Gly Ser Glu Pro Glu Pro 
            340                 345                 350         


Glu Pro Leu Trp Arg Arg Ile Thr Lys Arg Lys Leu Val Arg Pro Val 
        355                 360                 365             


Ala Thr Leu Met Trp Tyr Trp Phe Thr Ser Lys Arg His His His His 
    370                 375                 380                 


His His 
385     


<210>  187
<211>  387
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  187

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
                325                 330                 335     


Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly Ser Ala Gly Gly Pro 
            340                 345                 350         


Gly Ser Pro Leu Trp Arg Arg Ile Thr Lys Arg Lys Leu Val Arg Pro 
        355                 360                 365             


Val Ala Thr Leu Met Trp Tyr Trp Phe Thr Ser Lys Arg His His His 
    370                 375                 380                 


His His His 
385         


<210>  188
<211>  382
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  188

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Glu Pro Glu Gly Pro Gly Ser Gly Gly Ala Gly 
                325                 330                 335     


Ser Pro Gly Ser Ala Gly Gly Pro Gly Ser Glu Pro Glu Arg Met Leu 
            340                 345                 350         


Ser Arg Ile Leu Arg Met Phe Val Arg Ile Leu Lys Arg Glu Arg Leu 
        355                 360                 365             


Ser Gln Val Arg Gly Leu Phe Val His His His His His His 
    370                 375                 380         


<210>  189
<211>  383
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  189

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Glu Pro Glu Pro Glu Pro Glu Gly Pro Gly Ser 
                325                 330                 335     


Gly Gly Ala Gly Ser Pro Gly Ser Ala Gly Gly Pro Gly Ser Arg Met 
            340                 345                 350         


Leu Ser Arg Ile Leu Arg Met Phe Val Arg Ile Leu Lys Arg Glu Arg 
        355                 360                 365             


Leu Ser Gln Val Arg Gly Leu Phe Val His His His His His His 
    370                 375                 380             


<210>  190
<211>  390
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  190

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Glu Pro Glu Pro Glu Pro Glu Gly Pro Gly Ser 
                325                 330                 335     


Gly Gly Ala Gly Ser Pro Gly Ser Ala Gly Gly Pro Gly Ser Glu Pro 
            340                 345                 350         


Glu Pro Glu Pro Glu Leu Arg Phe Leu Ala Arg Arg Phe Leu Lys Leu 
        355                 360                 365             


Arg Arg Ala Arg Lys Trp Trp Asn Ala Trp Lys Val Trp Val Thr Arg 
    370                 375                 380                 


His His His His His His 
385                 390 


<210>  191
<211>  391
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  191

Met Ala Phe Phe Asp Leu Pro Leu Glu Glu Leu Lys Lys Tyr Arg Pro 
1               5                   10                  15      


Glu Arg Tyr Glu Glu Lys Asp Phe Asp Glu Phe Trp Glu Glu Thr Leu 
            20                  25                  30          


Ala Glu Ser Glu Lys Phe Pro Leu Asp Pro Val Phe Glu Arg Met Glu 
        35                  40                  45              


Ser His Leu Lys Thr Val Glu Ala Tyr Asp Val Thr Phe Ser Gly Tyr 
    50                  55                  60                  


Arg Gly Gln Arg Ile Lys Gly Trp Leu Leu Val Pro Lys Leu Glu Glu 
65                  70                  75                  80  


Glu Lys Leu Pro Cys Val Val Gln Tyr Ile Gly Tyr Asn Gly Gly Arg 
                85                  90                  95      


Gly Phe Pro His Asp Trp Leu Phe Trp Pro Ser Met Gly Tyr Ile Cys 
            100                 105                 110         


Phe Val Met Asp Thr Arg Gly Gln Gly Ser Gly Trp Leu Lys Gly Asp 
        115                 120                 125             


Thr Pro Asp Tyr Pro Glu Gly Pro Val Asp Pro Gln Tyr Pro Gly Phe 
    130                 135                 140                 


Met Thr Arg Gly Ile Leu Asp Pro Arg Thr Tyr Tyr Tyr Arg Arg Val 
145                 150                 155                 160 


Phe Thr Asp Ala Val Arg Ala Val Glu Ala Ala Ala Ser Phe Pro Gln 
                165                 170                 175     


Val Asp Gln Glu Arg Ile Val Ile Ala Gly Gly Ser Gln Gly Gly Gly 
            180                 185                 190         


Ile Ala Leu Ala Val Ser Ala Leu Ser Lys Lys Ala Lys Ala Leu Leu 
        195                 200                 205             


Cys Asp Val Pro Phe Leu Cys His Phe Arg Arg Ala Val Gln Leu Val 
    210                 215                 220                 


Asp Thr His Pro Tyr Ala Glu Ile Thr Asn Phe Leu Lys Thr His Arg 
225                 230                 235                 240 


Asp Lys Glu Glu Ile Val Phe Arg Thr Leu Ser Tyr Phe Asp Gly Val 
                245                 250                 255     


Asn Phe Ala Ala Arg Ala Lys Ile Pro Ala Leu Phe Ser Val Gly Leu 
            260                 265                 270         


Met Asp Asn Ile Ser Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn Tyr 
        275                 280                 285             


Tyr Ala Gly Pro Lys Glu Ile Arg Ile Tyr Pro Tyr Asn Asn His Glu 
    290                 295                 300                 


Gly Gly Gly Ser Phe Gln Ala Val Glu Gln Val Lys Phe Leu Lys Lys 
305                 310                 315                 320 


Leu Phe Glu Lys Gly Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
                325                 330                 335     


Pro Glu Pro Glu Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly Ser 
            340                 345                 350         


Ala Gly Gly Pro Gly Ser Leu Arg Phe Leu Ala Arg Arg Phe Leu Lys 
        355                 360                 365             


Leu Arg Arg Ala Arg Lys Trp Trp Asn Ala Trp Lys Val Trp Val Thr 
    370                 375                 380                 


Arg His His His His His His 
385                 390     


<210>  192
<211>  426
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  192

Met Gln Leu Phe Asp Leu Ser Leu Glu Glu Leu Lys Lys Tyr Lys Pro 
1               5                   10                  15      


Lys Lys Thr Ala Arg Pro Asp Phe Ser Asp Phe Trp Lys Lys Ser Leu 
            20                  25                  30          


Glu Glu Leu Arg Gln Val Glu Ala Glu Pro Thr Leu Glu Ser Tyr Asp 
        35                  40                  45              


Tyr Pro Val Lys Gly Val Lys Val Tyr Arg Leu Thr Tyr Gln Ser Phe 
    50                  55                  60                  


Gly His Ser Lys Ile Glu Gly Phe Tyr Ala Val Pro Asp Gln Thr Gly 
65                  70                  75                  80  


Pro His Pro Ala Leu Val Arg Phe His Gly Tyr Asn Ala Ser Tyr Asp 
                85                  90                  95      


Gly Gly Ile His Asp Ile Val Asn Trp Ala Leu His Gly Tyr Ala Thr 
            100                 105                 110         


Phe Gly Met Leu Val Arg Gly Gln Gly Gly Ser Glu Asp Thr Ser Val 
        115                 120                 125             


Thr Pro Gly Gly His Ala Leu Gly Trp Met Thr Lys Gly Ile Leu Ser 
    130                 135                 140                 


Lys Asp Thr Tyr Tyr Tyr Arg Gly Val Tyr Leu Asp Ala Val Arg Ala 
145                 150                 155                 160 


Leu Glu Val Ile Gln Ser Phe Pro Glu Val Asp Glu His Arg Ile Gly 
                165                 170                 175     


Val Ile Gly Gly Ser Gln Gly Gly Ala Leu Ala Ile Ala Ala Ala Ala 
            180                 185                 190         


Leu Ser Asp Ile Pro Lys Val Val Val Ala Asp Tyr Pro Tyr Leu Ser 
        195                 200                 205             


Asn Phe Glu Arg Ala Val Asp Val Ala Leu Glu Gln Pro Tyr Leu Glu 
    210                 215                 220                 


Ile Asn Ser Tyr Phe Arg Arg Asn Ser Asp Pro Lys Val Glu Glu Lys 
225                 230                 235                 240 


Ala Phe Glu Thr Leu Ser Tyr Phe Asp Leu Ile Asn Leu Ala Gly Trp 
                245                 250                 255     


Val Lys Gln Pro Thr Leu Met Ala Ile Gly Leu Ile Asp Lys Ile Thr 
            260                 265                 270         


Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His Leu Glu Thr Asp Lys 
        275                 280                 285             


Asp Leu Lys Val Tyr Arg Tyr Phe Gly His Glu Phe Ile Pro Ala Phe 
    290                 295                 300                 


Gln Thr Glu Lys Leu Ser Phe Leu Gln Lys His Leu Leu Leu Ser Thr 
305                 310                 315                 320 


Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly Ser Ala Gly Gly Pro 
                325                 330                 335     


Gly Ser Pro Ser Ala Gln Ser Gln Leu Pro Asp Lys His Ser Gly Leu 
            340                 345                 350         


His Glu Arg Ala Pro Gln Arg Tyr Gly Pro Glu Pro Glu Pro Glu Pro 
        355                 360                 365             


Glu Pro Ile Pro Glu Pro Pro Lys Glu Ala Pro Val Val Ile Glu Lys 
    370                 375                 380                 


Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Pro Ala His Asp His 
385                 390                 395                 400 


Lys Asn Gln Lys Glu Thr His Gln Arg His Ala Ala Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Pro His His His His His His 
            420                 425     


<210>  193
<211>  372
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  193

Met Gln Leu Phe Asp Leu Ser Leu Glu Glu Leu Lys Lys Tyr Lys Pro 
1               5                   10                  15      


Lys Lys Thr Ala Arg Pro Asp Phe Ser Asp Phe Trp Lys Lys Ser Leu 
            20                  25                  30          


Glu Glu Leu Arg Gln Val Glu Ala Glu Pro Thr Leu Glu Ser Tyr Asp 
        35                  40                  45              


Tyr Pro Val Lys Gly Val Lys Val Tyr Arg Leu Thr Tyr Gln Ser Phe 
    50                  55                  60                  


Gly His Ser Lys Ile Glu Gly Phe Tyr Ala Val Pro Asp Gln Thr Gly 
65                  70                  75                  80  


Pro His Pro Ala Leu Val Arg Phe His Gly Tyr Asn Ala Ser Tyr Asp 
                85                  90                  95      


Gly Gly Ile His Asp Ile Val Asn Trp Ala Leu His Gly Tyr Ala Thr 
            100                 105                 110         


Phe Gly Met Leu Val Arg Gly Gln Gly Gly Ser Glu Asp Thr Ser Val 
        115                 120                 125             


Thr Pro Gly Gly His Ala Leu Gly Trp Met Thr Lys Gly Ile Leu Ser 
    130                 135                 140                 


Lys Asp Thr Tyr Tyr Tyr Arg Gly Val Tyr Leu Asp Ala Val Arg Ala 
145                 150                 155                 160 


Leu Glu Val Ile Gln Ser Phe Pro Glu Val Asp Glu His Arg Ile Gly 
                165                 170                 175     


Val Ile Gly Gly Ser Gln Gly Gly Ala Leu Ala Ile Ala Ala Ala Ala 
            180                 185                 190         


Leu Ser Asp Ile Pro Lys Val Val Val Ala Asp Tyr Pro Tyr Leu Ser 
        195                 200                 205             


Asn Phe Glu Arg Ala Val Asp Val Ala Leu Glu Gln Pro Tyr Leu Glu 
    210                 215                 220                 


Ile Asn Ser Tyr Phe Arg Arg Asn Ser Asp Pro Lys Val Glu Glu Lys 
225                 230                 235                 240 


Ala Phe Glu Thr Leu Ser Tyr Phe Asp Leu Ile Asn Leu Ala Gly Trp 
                245                 250                 255     


Val Lys Gln Pro Thr Leu Met Ala Ile Gly Leu Ile Asp Lys Ile Thr 
            260                 265                 270         


Pro Pro Ser Thr Val Phe Ala Ala Tyr Asn His Leu Glu Thr Asp Lys 
        275                 280                 285             


Asp Leu Lys Val Tyr Arg Tyr Phe Gly His Glu Phe Ile Pro Ala Phe 
    290                 295                 300                 


Gln Thr Glu Lys Leu Ser Phe Leu Gln Lys His Leu Leu Leu Ser Thr 
305                 310                 315                 320 


Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly Ser Ala Gly Gly Pro 
                325                 330                 335     


Gly Ser Asp Pro Thr Lys Pro Pro Arg Thr Pro Thr Ala Asn Thr Ser 
            340                 345                 350         


Arg Pro His His Asn Phe Gly Ser Gly Gly Gly Gly Ser Pro His His 
        355                 360                 365             


His His His His 
    370         


<210>  194
<211>  429
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  194

Met Pro Phe Pro Asp Leu Ile Gln Pro Glu Leu Gly Ala Tyr Val Ser 
1               5                   10                  15      


Ser Val Gly Met Pro Asp Asp Phe Ala Gln Phe Trp Thr Ser Thr Ile 
            20                  25                  30          


Ala Glu Ala Arg Gln Ala Gly Gly Glu Val Ser Ile Val Gln Ala Gln 
        35                  40                  45              


Thr Thr Leu Lys Ala Val Gln Ser Phe Asp Val Thr Phe Pro Gly Tyr 
    50                  55                  60                  


Gly Gly His Pro Ile Lys Gly Trp Leu Ile Leu Pro Thr His His Lys 
65                  70                  75                  80  


Gly Arg Leu Pro Leu Val Val Gln Tyr Ile Gly Tyr Gly Gly Gly Arg 
                85                  90                  95      


Gly Leu Ala His Glu Gln Leu His Trp Ala Ala Ser Gly Phe Ala Tyr 
            100                 105                 110         


Phe Arg Met Asp Thr Arg Gly Gln Gly Ser Asp Trp Ser Val Gly Glu 
        115                 120                 125             


Thr Ala Asp Pro Val Gly Ser Thr Ser Ser Ile Pro Gly Phe Met Thr 
    130                 135                 140                 


Arg Gly Val Leu Asp Lys Asn Asp Tyr Tyr Tyr Arg Arg Leu Phe Thr 
145                 150                 155                 160 


Asp Ala Val Arg Ala Ile Asp Ala Leu Leu Gly Leu Asp Phe Val Asp 
                165                 170                 175     


Pro Glu Arg Ile Ala Val Cys Gly Asp Ser Gln Gly Gly Gly Ile Ser 
            180                 185                 190         


Leu Ala Val Gly Gly Ile Asp Pro Arg Val Lys Ala Val Met Pro Asp 
        195                 200                 205             


Val Pro Phe Leu Cys Asp Phe Pro Arg Ala Val Gln Thr Ala Val Arg 
    210                 215                 220                 


Asp Pro Tyr Leu Glu Ile Val Arg Phe Leu Ala Gln His Arg Glu Lys 
225                 230                 235                 240 


Lys Ala Ala Val Phe Glu Thr Leu Asn Tyr Phe Asp Cys Val Asn Phe 
                245                 250                 255     


Ala Arg Arg Ser Lys Ala Pro Ala Leu Phe Ser Val Ala Leu Met Asp 
            260                 265                 270         


Glu Val Cys Pro Pro Ser Thr Val Tyr Gly Ala Phe Asn Ala Tyr Ala 
        275                 280                 285             


Gly Glu Lys Thr Ile Thr Glu Tyr Glu Phe Asn Asn His Glu Gly Gly 
    290                 295                 300                 


Gln Gly Tyr Gln Glu Arg Gln Gln Met Thr Trp Leu Ser Arg Leu Phe 
305                 310                 315                 320 


Gly Val Gly Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly Ser Ala 
                325                 330                 335     


Gly Gly Pro Gly Ser Pro Ser Ala Gln Ser Gln Leu Pro Asp Lys His 
            340                 345                 350         


Ser Gly Leu His Glu Arg Ala Pro Gln Arg Tyr Gly Pro Glu Pro Glu 
        355                 360                 365             


Pro Glu Pro Glu Pro Ile Pro Glu Pro Pro Lys Glu Ala Pro Val Val 
    370                 375                 380                 


Ile Glu Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Pro Ala 
385                 390                 395                 400 


His Asp His Lys Asn Gln Lys Glu Thr His Gln Arg His Ala Ala Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Pro His His His His His His 
            420                 425                 


<210>  195
<211>  375
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  195

Met Pro Phe Pro Asp Leu Ile Gln Pro Glu Leu Gly Ala Tyr Val Ser 
1               5                   10                  15      


Ser Val Gly Met Pro Asp Asp Phe Ala Gln Phe Trp Thr Ser Thr Ile 
            20                  25                  30          


Ala Glu Ala Arg Gln Ala Gly Gly Glu Val Ser Ile Val Gln Ala Gln 
        35                  40                  45              


Thr Thr Leu Lys Ala Val Gln Ser Phe Asp Val Thr Phe Pro Gly Tyr 
    50                  55                  60                  


Gly Gly His Pro Ile Lys Gly Trp Leu Ile Leu Pro Thr His His Lys 
65                  70                  75                  80  


Gly Arg Leu Pro Leu Val Val Gln Tyr Ile Gly Tyr Gly Gly Gly Arg 
                85                  90                  95      


Gly Leu Ala His Glu Gln Leu His Trp Ala Ala Ser Gly Phe Ala Tyr 
            100                 105                 110         


Phe Arg Met Asp Thr Arg Gly Gln Gly Ser Asp Trp Ser Val Gly Glu 
        115                 120                 125             


Thr Ala Asp Pro Val Gly Ser Thr Ser Ser Ile Pro Gly Phe Met Thr 
    130                 135                 140                 


Arg Gly Val Leu Asp Lys Asn Asp Tyr Tyr Tyr Arg Arg Leu Phe Thr 
145                 150                 155                 160 


Asp Ala Val Arg Ala Ile Asp Ala Leu Leu Gly Leu Asp Phe Val Asp 
                165                 170                 175     


Pro Glu Arg Ile Ala Val Cys Gly Asp Ser Gln Gly Gly Gly Ile Ser 
            180                 185                 190         


Leu Ala Val Gly Gly Ile Asp Pro Arg Val Lys Ala Val Met Pro Asp 
        195                 200                 205             


Val Pro Phe Leu Cys Asp Phe Pro Arg Ala Val Gln Thr Ala Val Arg 
    210                 215                 220                 


Asp Pro Tyr Leu Glu Ile Val Arg Phe Leu Ala Gln His Arg Glu Lys 
225                 230                 235                 240 


Lys Ala Ala Val Phe Glu Thr Leu Asn Tyr Phe Asp Cys Val Asn Phe 
                245                 250                 255     


Ala Arg Arg Ser Lys Ala Pro Ala Leu Phe Ser Val Ala Leu Met Asp 
            260                 265                 270         


Glu Val Cys Pro Pro Ser Thr Val Tyr Gly Ala Phe Asn Ala Tyr Ala 
        275                 280                 285             


Gly Glu Lys Thr Ile Thr Glu Tyr Glu Phe Asn Asn His Glu Gly Gly 
    290                 295                 300                 


Gln Gly Tyr Gln Glu Arg Gln Gln Met Thr Trp Leu Ser Arg Leu Phe 
305                 310                 315                 320 


Gly Val Gly Gly Pro Gly Ser Gly Gly Ala Gly Ser Pro Gly Ser Ala 
                325                 330                 335     


Gly Gly Pro Gly Ser Asp Pro Thr Lys Pro Pro Arg Thr Pro Thr Ala 
            340                 345                 350         


Asn Thr Ser Arg Pro His His Asn Phe Gly Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Pro His His His His His His 
    370                 375 


<210>  196
<211>  418
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  196

Met Thr Lys Ile Asn Asn Trp Gln Asp Tyr Gln Gly Ser Ser Leu Lys 
1               5                   10                  15      


Pro Glu Asp Phe Asp Lys Phe Trp Asp Glu Lys Ile Asn Leu Val Ser 
            20                  25                  30          


Asn His Gln Phe Glu Phe Glu Leu Ile Glu Lys Asn Leu Ser Ser Lys 
        35                  40                  45              


Val Val Asn Phe Tyr His Leu Trp Phe Thr Ala Ile Asp Gly Ala Lys 
    50                  55                  60                  


Ile His Ala Gln Leu Ile Val Pro Lys Asn Leu Lys Glu Lys Tyr Pro 
65                  70                  75                  80  


Ala Ile Leu Gln Phe His Gly Tyr His Cys Asp Ser Gly Asp Trp Val 
                85                  90                  95      


Asp Lys Ile Gly Ile Val Ala Glu Gly Asn Val Val Leu Ala Leu Asp 
            100                 105                 110         


Cys Arg Gly Gln Gly Gly Leu Ser Gln Asp Asn Ile Gln Thr Met Gly 
        115                 120                 125             


Met Thr Met Lys Gly Leu Ile Val Arg Gly Ile Asp Glu Gly Tyr Glu 
    130                 135                 140                 


Asn Leu Tyr Tyr Val Arg Gln Phe Met Asp Leu Ile Thr Ala Thr Lys 
145                 150                 155                 160 


Ile Leu Ser Glu Phe Asp Phe Val Asp Glu Thr Asn Ile Ser Ala Gln 
                165                 170                 175     


Gly Ala Ser Gln Gly Gly Ala Leu Ala Val Ala Cys Ala Ala Leu Ser 
            180                 185                 190         


Pro Leu Ile Lys Lys Val Thr Ala Thr Tyr Pro Phe Leu Ser Asp Tyr 
        195                 200                 205             


Arg Lys Ala Tyr Glu Leu Gly Ala Glu Glu Ser Ala Phe Glu Glu Leu 
    210                 215                 220                 


Pro Tyr Trp Phe Gln Phe Lys Asp Pro Leu His Leu Arg Glu Asp Trp 
225                 230                 235                 240 


Phe Phe Asn Gln Leu Glu Tyr Ile Asp Ile Gln Asn Leu Ala Pro Arg 
                245                 250                 255     


Ile Lys Ala Glu Val Ile Trp Ile Leu Gly Gly Lys Asp Thr Val Val 
            260                 265                 270         


Pro Pro Ile Thr Gln Met Ala Ala Tyr Asn Lys Ile Gln Ser Lys Lys 
        275                 280                 285             


Ser Leu Tyr Val Leu Pro Glu Tyr Gly His Glu Tyr Leu Pro Lys Ile 
    290                 295                 300                 


Ser Asp Trp Leu Arg Glu Asn Gln Gly Pro Gly Ser Gly Gly Ala Gly 
305                 310                 315                 320 


Ser Pro Gly Ser Ala Gly Gly Pro Gly Ser Pro Ser Ala Gln Ser Gln 
                325                 330                 335     


Leu Pro Asp Lys His Ser Gly Leu His Glu Arg Ala Pro Gln Arg Tyr 
            340                 345                 350         


Gly Pro Glu Pro Glu Pro Glu Pro Glu Pro Ile Pro Glu Pro Pro Lys 
        355                 360                 365             


Glu Ala Pro Val Val Ile Glu Lys Pro Lys Pro Lys Pro Lys Pro Lys 
    370                 375                 380                 


Pro Lys Pro Pro Ala His Asp His Lys Asn Gln Lys Glu Thr His Gln 
385                 390                 395                 400 


Arg His Ala Ala Gly Ser Gly Gly Gly Gly Ser Pro His His His His 
                405                 410                 415     


His His 
        


<210>  197
<211>  363
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  197

Met Thr Lys Ile Asn Asn Trp Gln Asp Tyr Gln Gly Ser Ser Leu Lys 
1               5                   10                  15      


Pro Glu Asp Phe Asp Lys Phe Trp Asp Glu Lys Ile Asn Leu Val Ser 
            20                  25                  30          


Asn His Gln Phe Glu Phe Glu Leu Ile Glu Lys Asn Leu Ser Ser Lys 
        35                  40                  45              


Val Val Asn Phe Tyr His Leu Trp Phe Thr Ala Ile Asp Gly Ala Lys 
    50                  55                  60                  


Ile His Ala Gln Leu Ile Val Pro Lys Asn Leu Lys Glu Lys Tyr Pro 
65                  70                  75                  80  


Ala Ile Leu Gln Phe His Gly Tyr His Cys Asp Ser Gly Asp Trp Val 
                85                  90                  95      


Asp Lys Ile Gly Ile Val Ala Glu Gly Asn Val Val Leu Ala Leu Asp 
            100                 105                 110         


Cys Arg Gly Gln Gly Gly Leu Ser Gln Asp Asn Ile Gln Thr Met Gly 
        115                 120                 125             


Met Thr Met Lys Gly Leu Ile Val Arg Gly Ile Asp Glu Gly Tyr Glu 
    130                 135                 140                 


Asn Leu Tyr Tyr Val Arg Gln Phe Met Asp Leu Ile Thr Ala Thr Lys 
145                 150                 155                 160 


Ile Leu Ser Glu Phe Asp Phe Val Asp Glu Thr Asn Ile Ser Ala Gln 
                165                 170                 175     


Gly Ala Ser Gln Gly Gly Ala Leu Ala Val Ala Cys Ala Ala Leu Ser 
            180                 185                 190         


Pro Leu Ile Lys Lys Val Thr Ala Thr Tyr Pro Phe Leu Ser Asp Tyr 
        195                 200                 205             


Arg Lys Ala Tyr Glu Leu Gly Ala Glu Glu Ser Ala Phe Glu Glu Leu 
    210                 215                 220                 


Pro Tyr Trp Phe Gln Phe Lys Asp Pro Leu His Leu Arg Glu Asp Trp 
225                 230                 235                 240 


Phe Phe Asn Gln Leu Glu Tyr Ile Asp Ile Gln Asn Leu Ala Pro Arg 
                245                 250                 255     


Ile Lys Ala Glu Val Ile Trp Ile Leu Gly Gly Lys Asp Thr Val Val 
            260                 265                 270         


Pro Pro Ile Thr Gln Met Ala Ala Tyr Asn Lys Ile Gln Ser Lys Lys 
        275                 280                 285             


Ser Leu Tyr Val Leu Pro Glu Tyr Gly His Glu Tyr Leu Pro Lys Ile 
    290                 295                 300                 


Ser Asp Trp Leu Arg Glu Asn Gln Gly Pro Gly Ser Gly Gly Ala Gly 
305                 310                 315                 320 


Ser Pro Gly Ser Ala Gly Gly Pro Gly Ser Asp Pro Thr Lys Pro Pro 
                325                 330                 335     


Arg Thr Pro Thr Ala Asn Thr Ser Arg Pro His His Asn Phe Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Pro His His His His His 
        355                 360             


