
                                SEQUENCE LISTING

<110> BIOALLIANCE C.V.
      LIN, Shih-Yao
      LIN, Leewen
      TSAI, Yu-Ying
      HUANG, Chiu-Chen 
      CHIANG, Feng-Lin 
      HSIEH, Yu-Chi 

<120> ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND
  METHODS USING SAME

<130> 606592000740

<140> Not Yet Assigned    
<141> Concurrently Herewith

<150> US 61/584,125       
<151> 2012-01-06  

<160> 19

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 138
<212> PRT
<213> Mus musculus

<400> 1
Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly
 1               5                  10                  15      
Val Leu Ser Glu Val Glu Leu Gln Gln Phe Gly Ile Glu Met Val Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe
        35                  40                  45              
Thr Asp Tyr His Met Asp Trp Val Arg Gln Ser His Gly Lys Ser Leu
    50                  55                  60                  
Glu Trp Ile Gly Asp Ile Asp Pro Lys Tyr Asp Arg Val Thr Tyr Asn
65                  70                  75                  80  
Gln Lys Phe Lys Gly Lys Ala Ser Leu Thr Ala Asp Lys Ser Ser Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Lys Thr Gly Ala Tyr Gly Asp Tyr Leu Ala Tyr Trp
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala
    130                 135             


<210> 2
<211> 414
<212> DNA
<213> Mus musculus

<400> 2
atggaatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctctgag 60
gtcgagctgc aacagtttgg aattgagatg gtgaagcctg gggcttcagt gaagatatcc 120
tgcaaggcct ctggctacat attcactgac taccacatgg actgggtgag gcagagccat 180
ggcaagagcc ttgagtggat tggagatatt gatcctaaat atgatagagt tacctataac 240
cagaagttca agggaaaggc ctcactgact gcagacaagt cctccagcac agcctacatg 300
gaactccgca gcctgacatc tgaggacact gcagtctatt actgtgcaaa gacgggggcg 360
tatggtgatt atcttgctta ctggggccag gggactctgg tcactgtctc cgca       414

<210> 3
<211> 132
<212> PRT
<213> Mus musculus

<400> 3
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala
 1               5                  10                  15      
Ser Ser Ser Asp Leu Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val
            20                  25                  30          
Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu
        35                  40                  45              
Val His Ser Asp Gly Asn Thr Tyr Phe Tyr Trp Tyr Leu Gln Lys Pro
    50                  55                  60                  
Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Ala Gly Gly Ser Gly Thr Tyr Phe Thr
                85                  90                  95      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys
            100                 105                 110         
Ser Gln Thr Thr His Phe Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Lys Arg
    130         


<210> 4
<211> 396
<212> DNA
<213> Mus musculus

<400> 4
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat 60
cttgttatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc 120
tcttgcagat ctagtcagag ccttgtacac agtgatggaa acacctattt ctattggtac 180
ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct 240
ggggtcccag acaggttcag tgccggtgga tcagggacat atttcacact caagatcagc 300
agagtggagg ctgaggatct gggagtttat ttctgctctc aaactacaca ttttcctccg 360
acgttcggtg gaggcaccaa gctggaaatc aaacgg                           396

<210> 5
<211> 138
<212> PRT
<213> Mus musculus

<400> 5
Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys
            20                  25                  30          
Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Phe
        35                  40                  45              
Thr Ser Tyr Trp Ile Asn Trp Val Lys Leu Arg Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Ile Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asn
65                  70                  75                  80  
Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser
                85                  90                  95      
Thr Ala Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Leu
            100                 105                 110         
Tyr Tyr Cys Ala Arg Ser Ala Tyr Arg Tyr Asp Trp Phe Ala Tyr Trp
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala
    130                 135             


<210> 6
<211> 414
<212> DNA
<213> Mus musculus

<400> 6
atgggatgga gctatatcat cctcttcttg gtagcaacag ctacaggtgt ccactctcag 60
gtccaactgc agcagcctgg ggctgagctt gtgaagcctg ggacttcagt gaagctgtcc 120
tgcaaggctt ctggctacaa cttcaccagc tactggataa actgggtgaa gctgaggcct 180
ggacaaggcc ttgagtggat tggagatatt tatcctggta gtggtagtac taactacaat 240
gagaagttca agagcaaggc cacactgact gtagacacat cctccagcac agcctacatg 300
caactcagca gcctggcatc tgaggactct gctctctatt actgtgcaag atccgcctat 360
aggtacgact ggtttgctta ctggggccaa gggactctgg tcactgtctc tgca       414

<210> 7
<211> 128
<212> PRT
<213> Mus musculus

<400> 7
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser
            20                  25                  30          
Val Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn
        35                  40                  45              
Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro
    50                  55                  60                  
Gln Leu Leu Val Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn
                85                  90                  95      
Ser Leu Gln Ser Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp
            100                 105                 110         
Gly Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
        115                 120                 125             


<210> 8
<211> 384
<212> DNA
<213> Mus musculus

<400> 8
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgt 60
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc 120
atcacatgtc gagcaagtga gaatatttac agtaatttag catggtatca gcagaaacag 180
ggaaaatctc ctcagctcct ggtctatgct gcaacaaact tagcagatgg tgtgccatca 240
aggttcagtg gcagtggatc aggcacacag tattccctca agatcaacag cctgcagtct 300
gaagattttg ggagttatta ctgtcaacat ttttggggta ctccgtacac gttcggaggg 360
gggaccaagc tggaaataaa acgg                                        384

<210> 9
<211> 136
<212> PRT
<213> Mus musculus

<400> 9
Met Leu Leu Gly Leu Lys Trp Val Phe Phe Val Val Phe Tyr Gln Gly
 1               5                  10                  15      
Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
            20                  25                  30          
Pro Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser
                85                  90                  95      
Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr
            100                 105                 110         
Ala Met Tyr Tyr Cys Val Ala Tyr Gly Ser Arg Asn Tyr Trp Gly Gln
        115                 120                 125             
Gly Thr Thr Leu Thr Val Ser Ser
    130                 135     


<210> 10
<211> 408
<212> DNA
<213> Mus musculus

<400> 10
atgctgttgg ggctgaagtg ggttttcttt gttgtttttt atcaaggtgt gcattgtgag 60
gtgcagcttg ttgagtctgg tggaggattg gtgcagccta aagggtcatt gaaactctca 120
tgtgcagcct ctggattcac cttcaatacc tacgccatga actgggtccg ccaggctcca 180
ggaaagggtt tggaatgggt tgctcgcata agaagtaaaa gtaataatta tgcaacatat 240
tatgccgatt cagtgaaaga caggttcacc atctccagag atgattcaca aagcatgctc 300
tatctgcaaa tgaacaactt gaaaactgag gacacagcca tgtattactg tgtggcttac 360
ggtagtagaa actactgggg ccaaggcacc actctcacag tctcctca              408

<210> 11
<211> 134
<212> PRT
<213> Mus musculus

<400> 11
Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser
 1               5                  10                  15      
Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr
            20                  25                  30          
Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser
        35                  40                  45              
Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln
    50                  55                  60                  
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg
65                  70                  75                  80  
Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp
                85                  90                  95      
Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr
            100                 105                 110         
Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr
        115                 120                 125             
Lys Leu Glu Ile Lys Arg
    130                 


<210> 12
<211> 402
<212> DNA
<213> Mus musculus

<400> 12
atggaatcac agactcaggt cctcatgtcc ctgctgttct gggtatctgg tacctgtggg 60
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact 120
atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc 180
tggtaccagc agaaaccagg gcagcctcct aaactgttga tctactgggc atccactagg 240
gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc 300
atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga ttatagttat 360
ccgtacacgt tcggaggggg gaccaagctg gaaataaaac gg                    402

<210> 13
<211> 138
<212> PRT
<213> Mus musculus

<400> 13
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly
 1               5                  10                  15      
Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys
            20                  25                  30          
Pro Gly Ala Ser Met Lys Met Ser Cys Lys Thr Ser Gly Tyr Lys Phe
        35                  40                  45              
Thr Gly Tyr Tyr Met Asp Trp Val Lys Gln Ser Leu Gly Ala Ser Phe
    50                  55                  60                  
Glu Trp Ile Gly Arg Val Ile Pro Ser Asn Gly Asp Thr Arg Tyr Asn
65                  70                  75                  80  
Gln Lys Phe Glu Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Lys Pro Leu Ser Gly Asn Ala Ala Asp Tyr Trp
        115                 120                 125             
Gly Gln Gly Thr Ser Val Thr Val Ser Thr
    130                 135             


<210> 14
<211> 414
<212> DNA
<213> Mus musculus

<400> 14
atgggatgga gctggatctt tctcttcctc ttgtcaggaa ctgcaggtgt ccactctgag 60
gtccagctgc aacagtctgg acctgaggtg gtgaagcctg gggcttcaat gaagatgtcc 120
tgtaagactt ctggatacaa attcactggc tactacatgg actgggtgaa gcagagcctt 180
ggagcaagct ttgagtggat tggacgtgtt attccttcca atggtgatac taggtacaac 240
cagaagttcg agggcaaggc cacattgact gttgacaggt cctccagcac agcctacatg 300
gagctcaaca gcctgacatc tgaagactct gcggtctatt actgtgcaag aaaaccgcta 360
agtgggaatg ctgcggacta ctggggtcaa ggaacctcag tcaccgtctc caca       414

<210> 15
<211> 130
<212> PRT
<213> Mus musculus

<400> 15
Met Thr Met Leu Ser Leu Ala Pro Leu Leu Ser Leu Leu Leu Leu Cys
 1               5                  10                  15      
Val Ser Asp Ser Arg Ala Glu Thr Thr Val Thr Gln Ser Pro Ala Ser
            20                  25                  30          
Leu Ser Val Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Ile Thr Ser
        35                  40                  45              
Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu
    50                  55                  60                  
Pro Pro Lys Leu Leu Ile Ser Asp Gly Asn Thr Leu Arg Pro Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Ser Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr
                85                  90                  95      
Ile Glu Asn Thr Leu Ser Glu Asp Ile Thr Asp Tyr Tyr Cys Met Gln
            100                 105                 110         
Ser Asp Asn Met Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile
        115                 120                 125             
Lys Arg
    130 


<210> 16
<211> 390
<212> DNA
<213> Mus musculus

<400> 16
atgaccatgc tctcactagc tcctctcctc agccttcttc tcctctgtgt ctctgattct 60
agggcagaaa caactgtgac ccagtctcca gcatccctgt ccgtggctac aggagagaaa 120
gtcactatca gatgcataac tagcactgat attgatgatg atatgaactg gtaccaacag 180
aagccagggg aacctcctaa actccttatt tcagatggca atactcttcg tcctggagtc 240
ccatcccgat tctccagcag tggctatggc acagattttg tttttacaat tgaaaacacg 300
ctctcagaag atattacaga ttactactgt atgcagagtg ataacatgcc attcacgttc 360
ggctcgggga caaagttgga aataaaacgg                                  390

<210> 17
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Met Lys Met Ser Cys Lys Thr Ser Gly Tyr Lys Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met Asp Trp Val Lys Gln Ser Leu Gly Ala Ser Phe Glu Trp Ile
        35                  40                  45              
Gly Arg Val Ile Pro Ser Asn Gly Asp Thr Arg Tyr Asn Gln Lys Phe
    50                  55                  60                  
Glu Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Pro Leu Ser Gly Asn Ala Ala Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Ser Val Thr Val Ser Thr Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350         
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445             
Lys
    


<210> 18
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly
 1               5                  10                  15      
Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp
            20                  25                  30          
Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Leu Leu Ile
        35                  40                  45              
Ser Asp Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser
65                  70                  75                  80  
Glu Asp Ile Thr Asp Tyr Tyr Cys Met Gln Ser Asp Asn Met Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 19
<211> 760
<212> PRT
<213> Homo sapiens

<400> 19
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu
 1               5                  10                  15      
Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp
            20                  25                  30          
Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala
        35                  40                  45              
Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly
    50                  55                  60                  
Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly
65                  70                  75                  80  
Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr
                85                  90                  95      
Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro
            100                 105                 110         
Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys
        115                 120                 125             
Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile
    130                 135                 140                 
Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln
145                 150                 155                 160 
Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe
                165                 170                 175     
Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val
            180                 185                 190         
Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg
        195                 200                 205             
Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys
    210                 215                 220                 
Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys
225                 230                 235                 240 
Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile
                245                 250                 255     
Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu
            260                 265                 270         
Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe
        275                 280                 285             
Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly
    290                 295                 300                 
Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln
305                 310                 315                 320 
Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr
                325                 330                 335     
Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp
            340                 345                 350         
Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser
        355                 360                 365             
Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile
    370                 375                 380                 
Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp
385                 390                 395                 400 
His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala
                405                 410                 415     
Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met
            420                 425                 430         
Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile
        435                 440                 445             
Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr
    450                 455                 460                 
Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr
465                 470                 475                 480 
Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val
                485                 490                 495     
Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn
            500                 505                 510         
Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp
        515                 520                 525             
Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe
    530                 535                 540                 
Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp
545                 550                 555                 560 
Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu
                565                 570                 575     
Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu
            580                 585                 590         
Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn
        595                 600                 605             
Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp
    610                 615                 620                 
Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln
625                 630                 635                 640 
Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu
                645                 650                 655     
Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys
            660                 665                 670         
Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro
        675                 680                 685             
Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser
    690                 695                 700                 
Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys
705                 710                 715                 720 
Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala
                725                 730                 735     
Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp
            740                 745                 750         
Val Trp Asp Ile Asp Asn Glu Phe
        755                 760 

