                         SEQUENCE LISTING

<110>  Gilead Pharmasset LLC
 
<120>  CRYSTAL STRUCTURE OF HCV POLYMERASE COMPLEXES AND METHODS OF USE

<130>  03956.055900.PV

<150>  US 61/586,584
<151>  2012-01-13

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  1

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ser Pro 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


Tyr His Asn Lys Val Tyr Cys Thr Thr Ser Lys Ser Ala Ser Gln Arg 
        35                  40                  45              


Ala Lys Lys Val Thr Phe Asp Arg Thr Gln Val Leu Asp Ala His Tyr 
    50                  55                  60                  


Asp Ser Val Leu Lys Asp Ile Lys Leu Ala Ala Ser Lys Val Ser Ala 
65                  70                  75                  80  


Arg Leu Leu Thr Leu Glu Glu Ala Cys Gln Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Lys Tyr Gly Phe Gly Ala Lys Glu Val Arg Ser Leu Ser 
            100                 105                 110         


Gly Arg Ala Val Asn His Ile Lys Ser Val Trp Lys Asp Leu Leu Glu 
        115                 120                 125             


Asp Pro Gln Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Asp Pro Ala Lys Gly Gly Lys Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Ile Thr Gln Lys Leu Pro Gln Ala Val Met Gly Ala Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Ala Gln Arg Val Glu Tyr Leu Leu Lys Ala Trp 
        195                 200                 205             


Ala Glu Lys Lys Asp Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Gln Ala Cys Ser Leu Pro Glu Glu Ala Arg Thr Ala Ile His Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Val Gly Gly Pro Met Phe Asn Ser Lys Gly Gln 
            260                 265                 270         


Thr Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Met Gly Asn Thr Ile Thr Cys Tyr Val Lys Ala Leu Ala Ala Cys Lys 
    290                 295                 300                 


Ala Ala Gly Ile Val Ala Pro Thr Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Ser Glu Ser Gln Gly Thr Glu Glu Asp Glu Arg Asn Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Arg Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala Leu Gly Pro Arg Gly Arg Arg Arg Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Val 
385                 390                 395                 400 


Arg His Ser Pro Ile Asn Ser Trp Leu Gly Asn Ile Ile Gln Tyr Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Val Leu Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Met Val Gln Asp Thr Leu Asp Gln Asn Leu Asn Phe Glu Met Tyr 
        435                 440                 445             


Gly Ser Val Tyr Ser Val Asn Pro Leu Asp Leu Pro Ala Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Asp Ala Phe Ser Met His Thr Tyr Ser His His 
465                 470                 475                 480 


Glu Leu Thr Arg Val Ala Ser Ala Leu Arg Lys Leu Gly Ala Pro Pro 
                485                 490                 495     


Leu Arg Val Trp Lys Ser Arg Ala Arg Ala Val Arg Ala Ser Leu Ile 
            500                 505                 510         


Ser Arg Gly Gly Lys Ala Ala Val Cys Gly Arg Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Leu Pro Glu Ala Arg Leu 
    530                 535                 540                 


Leu Asp Leu Ser Ser Trp Phe Thr Val Gly Ala Gly Gly Gly Asp Ile 
545                 550                 555                 560 


Phe His Ser Val Ser Arg Ala Arg Pro Arg Ser Leu Leu Phe Gly Leu 
                565                 570                 575     


Leu Leu Leu Phe Val Gly Val Gly Leu Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  2
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  2

Ser Met Ser Tyr Thr Trp Thr Gly Ala Leu Ile Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Ser Lys Leu Pro Ile Asn Ala Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


His His Asn Met Val Tyr Ala Thr Thr Ser Arg Ser Ala Gly Leu Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His Tyr 
    50                  55                  60                  


Arg Asp Val Leu Lys Glu Met Lys Ala Lys Ala Ser Thr Val Lys Ala 
65                  70                  75                  80  


Lys Leu Leu Ser Val Glu Glu Ala Cys Lys Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val Arg Asn Leu Ser 
            100                 105                 110         


Ser Lys Ala Val Asn His Ile His Ser Val Trp Lys Asp Leu Leu Glu 
        115                 120                 125             


Asp Thr Val Thr Pro Ile Asp Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Gln Pro Glu Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Phe Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Val Val Ser Thr Leu Pro Gln Val Val Met Gly Ser Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Gly Gln Arg Val Glu Phe Leu Val Asn Thr Trp 
        195                 200                 205             


Lys Ser Lys Lys Asn Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Asn Asp Ile Arg Val Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Gln Cys Cys Asp Leu Ala Pro Glu Ala Arg Gln Ala Ile Lys Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Ile Gly Gly Pro Leu Thr Asn Ser Lys Gly Gln 
            260                 265                 270         


Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Cys Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Ser Ala Ala Cys Arg 
    290                 295                 300                 


Ala Ala Lys Leu Gln Asp Cys Thr Met Leu Val Asn Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Cys Glu Ser Ala Gly Thr Gln Glu Asp Ala Ala Ser Leu 
                325                 330                 335     


Arg Val Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Ala Ser Gly Lys Arg Val Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Tyr Ala 
                405                 410                 415     


Pro Thr Leu Trp Ala Arg Met Ile Leu Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Leu Ala Gln Glu Gln Leu Glu Lys Ala Leu Asp Cys Gln Ile Tyr 
        435                 440                 445             


Gly Ala Cys Tyr Ser Ile Glu Pro Leu Asp Leu Pro Gln Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro Gly 
465                 470                 475                 480 


Glu Ile Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly Val Pro Pro 
                485                 490                 495     


Leu Arg Val Trp Arg His Arg Ala Arg Ser Val Arg Ala Arg Leu Leu 
            500                 505                 510         


Ser Gln Gly Gly Arg Ala Ala Thr Cys Gly Lys Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Ile Pro Ala Ala Ser Arg 
    530                 535                 540                 


Leu Asp Leu Ser Gly Trp Phe Val Ala Gly Tyr Ser Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Leu Ser Arg Ala Arg Pro Arg Trp Phe Met Leu Cys Leu 
                565                 570                 575     


Leu Leu Leu Ser Val Gly Val Gly Ile Tyr Leu Leu Pro Asn Arg 
            580                 585                 590     


<210>  3
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2a WT  [HCV NS5b 2a (1-565, WT, E86Q, E87Q)]His-6

<400>  3

Met Ser Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys 
1               5                   10                  15      


Ser Pro Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu 
            20                  25                  30          


Leu Arg Tyr His Asn Lys Val Tyr Cys Thr Thr Ser Lys Ser Ala Ser 
        35                  40                  45              


Gln Arg Ala Lys Lys Val Thr Phe Asp Arg Thr Gln Val Leu Asp Ala 
    50                  55                  60                  


His Tyr Asp Ser Val Leu Lys Leu Ala Ala Ser Lys Val Ser Ala Arg 
65                  70                  75                  80  


Leu Leu Thr Leu Gln Gln Ala Cys Gln Leu Thr Pro Pro His Ser Ala 
                85                  90                  95      


Arg Ser Lys Tyr Gly Phe Gly Ala Lys Glu Val Arg Ser Leu Ser Gly 
            100                 105                 110         


Arg Ala Val Asn His Ile Lys Ser Val Trp Lys Asp Leu Leu Glu Asp 
        115                 120                 125             


Pro Gln Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val Phe 
    130                 135                 140                 


Cys Val Asp Pro Ala Lys Gly Gly Lys Lys Pro Ala Arg Leu Ile Val 
145                 150                 155                 160 


Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr Asp 
                165                 170                 175     


Ile Thr Gln Lys Leu Pro Gln Ala Val Met Gly Ala Ser Tyr Gly Phe 
            180                 185                 190         


Gln Tyr Ser Pro Ala Gln Arg Val Glu Tyr Leu Leu Lys Ala Trp Ala 
        195                 200                 205             


Glu Lys Lys Asp Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp 
    210                 215                 220                 


Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Ser Ile Tyr Gln 
225                 230                 235                 240 


Ala Cys Ser Leu Pro Glu Glu Ala Arg Thr Ala Ile His Ser Leu Thr 
                245                 250                 255     


Glu Arg Leu Tyr Val Gly Gly Pro Met Phe Asn Ser Lys Gly Gln Thr 
            260                 265                 270         


Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser Met 
        275                 280                 285             


Gly Asn Thr Ile Thr Cys Tyr Val Lys Ala Leu Ala Ala Cys Lys Ala 
    290                 295                 300                 


Ala Gly Ile Val Ala Pro Thr Met Leu Val Cys Gly Asp Asp Leu Val 
305                 310                 315                 320 


Val Ile Ser Glu Ser Gln Gly Thr Glu Glu Asp Glu Arg Asn Leu Arg 
                325                 330                 335     


Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp Pro 
            340                 345                 350         


Pro Arg Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser Asn 
        355                 360                 365             


Val Ser Val Ala Leu Gly Pro Arg Gly Arg Arg Arg Tyr Tyr Leu Thr 
    370                 375                 380                 


Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Val Arg 
385                 390                 395                 400 


His Ser Pro Ile Asn Ser Trp Leu Gly Asn Ile Ile Gln Tyr Ala Pro 
                405                 410                 415     


Thr Ile Trp Val Arg Met Val Leu Met Thr His Phe Phe Ser Ile Leu 
            420                 425                 430         


Met Val Gln Asp Thr Leu Asp Gln Asn Leu Asn Phe Glu Met Tyr Gly 
        435                 440                 445             


Ser Val Tyr Ser Val Asn Pro Leu Asp Leu Pro Ala Ile Ile Glu Arg 
    450                 455                 460                 


Leu His Gly Leu Asp Ala Phe Ser Met His Thr Tyr Ser His His Glu 
465                 470                 475                 480 


Leu Thr Arg Val Ala Ser Ala Leu Arg Lys Leu Gly Ala Pro Pro Leu 
                485                 490                 495     


Arg Val Trp Lys Ser Arg Ala Arg Ala Val Arg Ala Ser Leu Ile Ser 
            500                 505                 510         


Arg Gly Gly Lys Ala Ala Val Cys Gly Arg Tyr Leu Phe Asn Trp Ala 
        515                 520                 525             


Val Lys Thr Lys Leu Lys Leu Thr Pro Leu Pro Glu Ala Arg Leu Leu 
    530                 535                 540                 


Asp Leu Ser Ser Trp Phe Thr Val Gly Ala Gly Gly Gly Asp Ile Phe 
545                 550                 555                 560 


His Ser Val Ser Arg Ala Arg Pro Arg Leu Glu His His His His His 
                565                 570                 575     


His 
    


<210>  4
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1b WT  His-6[HCV NS5b 1B (1-570, L47Q, E86Q, E87Q, K114R, C-term 
       delta21)]

<400>  4

Met Ala Ser His His His His His His Ser Met Ser Tyr Thr Trp Thr 
1               5                   10                  15      


Gly Ala Leu Ile Thr Pro Cys Ala Ala Glu Glu Ser Lys Leu Pro Ile 
            20                  25                  30          


Asn Ala Leu Ser Asn Ser Leu Leu Arg His His Asn Met Val Tyr Ala 
        35                  40                  45              


Thr Thr Ser Arg Ser Ala Gly Gln Arg Gln Lys Lys Val Thr Phe Asp 
    50                  55                  60                  


Arg Leu Gln Val Leu Asp Asp His Tyr Arg Asp Val Leu Lys Glu Met 
65                  70                  75                  80  


Lys Ala Lys Ala Ser Thr Val Lys Ala Lys Leu Leu Ser Val Gln Gln 
                85                  90                  95      


Ala Cys Lys Leu Thr Pro Pro His Ser Ala Lys Ser Lys Phe Gly Tyr 
            100                 105                 110         


Gly Ala Lys Asp Val Arg Asn Leu Ser Ser Arg Ala Val Asn His Ile 
        115                 120                 125             


His Ser Val Trp Lys Asp Leu Leu Glu Asp Thr Val Thr Pro Ile Asp 
    130                 135                 140                 


Thr Thr Ile Met Ala Lys Asn Glu Val Phe Cys Val Gln Pro Glu Lys 
145                 150                 155                 160 


Gly Gly Arg Lys Pro Ala Arg Leu Ile Val Phe Pro Asp Leu Gly Val 
                165                 170                 175     


Arg Val Cys Glu Lys Met Ala Leu Tyr Asp Val Val Ser Thr Leu Pro 
            180                 185                 190         


Gln Val Val Met Gly Ser Ser Tyr Gly Phe Gln Tyr Ser Pro Gly Gln 
        195                 200                 205             


Arg Val Glu Phe Leu Val Asn Thr Trp Lys Ser Lys Lys Asn Pro Met 
    210                 215                 220                 


Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp Ser Thr Val Thr Glu Asn 
225                 230                 235                 240 


Asp Ile Arg Val Glu Glu Ser Ile Tyr Gln Cys Cys Asp Leu Ala Pro 
                245                 250                 255     


Glu Ala Arg Gln Ala Ile Lys Ser Leu Thr Glu Arg Leu Tyr Ile Gly 
            260                 265                 270         


Gly Pro Leu Thr Asn Ser Lys Gly Gln Asn Cys Gly Tyr Arg Arg Cys 
        275                 280                 285             


Arg Ala Ser Gly Val Leu Thr Thr Ser Cys Gly Asn Thr Leu Thr Cys 
    290                 295                 300                 


Tyr Leu Lys Ala Ser Ala Ala Cys Arg Ala Ala Lys Leu Gln Asp Cys 
305                 310                 315                 320 


Thr Met Leu Val Asn Gly Asp Asp Leu Val Val Ile Cys Glu Ser Ala 
                325                 330                 335     


Gly Thr Gln Glu Asp Ala Ala Ser Leu Arg Val Phe Thr Glu Ala Met 
            340                 345                 350         


Thr Arg Tyr Ser Ala Pro Pro Gly Asp Pro Pro Gln Pro Glu Tyr Asp 
        355                 360                 365             


Leu Glu Leu Ile Thr Ser Cys Ser Ser Asn Val Ser Val Ala His Asp 
    370                 375                 380                 


Ala Ser Gly Lys Arg Val Tyr Tyr Leu Thr Arg Asp Pro Thr Thr Pro 
385                 390                 395                 400 


Leu Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val Asn Ser 
                405                 410                 415     


Trp Leu Gly Asn Ile Ile Met Tyr Ala Pro Thr Leu Trp Ala Arg Met 
            420                 425                 430         


Ile Leu Met Thr His Phe Phe Ser Ile Leu Leu Ala Gln Glu Gln Leu 
        435                 440                 445             


Glu Lys Ala Leu Asp Cys Gln Ile Tyr Gly Ala Cys Tyr Ser Ile Glu 
    450                 455                 460                 


Pro Leu Asp Leu Pro Gln Ile Ile Glu Arg Leu His Gly Leu Ser Ala 
465                 470                 475                 480 


Phe Ser Leu His Ser Tyr Ser Pro Gly Glu Ile Asn Arg Val Ala Ser 
                485                 490                 495     


Cys Leu Arg Lys Leu Gly Val Pro Pro Leu Arg Val Trp Arg His Arg 
            500                 505                 510         


Ala Arg Ser Val Arg Ala Arg Leu Leu Ser Gln Gly Gly Arg Ala Ala 
        515                 520                 525             


Thr Cys Gly Lys Tyr Leu Phe Asn Trp Ala Val Lys Thr Lys Leu Lys 
    530                 535                 540                 


Leu Thr Pro Ile Pro Ala Ala Ser Gln Leu Asp Leu Ser Gly Trp Phe 
545                 550                 555                 560 


Val Ala Gly Tyr Ser Gly Gly Asp Ile Tyr His Ser Leu Ser Arg Ala 
                565                 570                 575     


Arg Pro Arg 
            


<210>  5
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1b S282T  His-6[HCV NS5b 1B (1-570, L47Q, E86Q, E87Q, K114R, 
       S282T, C-term delta21)]

<400>  5

Met Ala Ser His His His His His His Ser Met Ser Tyr Thr Trp Thr 
1               5                   10                  15      


Gly Ala Leu Ile Thr Pro Cys Ala Ala Glu Glu Ser Lys Leu Pro Ile 
            20                  25                  30          


Asn Ala Leu Ser Asn Ser Leu Leu Arg His His Asn Met Val Tyr Ala 
        35                  40                  45              


Thr Thr Ser Arg Ser Ala Gly Gln Arg Gln Lys Lys Val Thr Phe Asp 
    50                  55                  60                  


Arg Leu Gln Val Leu Asp Asp His Tyr Arg Asp Val Leu Lys Glu Met 
65                  70                  75                  80  


Lys Ala Lys Ala Ser Thr Val Lys Ala Lys Leu Leu Ser Val Gln Gln 
                85                  90                  95      


Ala Cys Lys Leu Thr Pro Pro His Ser Ala Lys Ser Lys Phe Gly Tyr 
            100                 105                 110         


Gly Ala Lys Asp Val Arg Asn Leu Ser Ser Arg Ala Val Asn His Ile 
        115                 120                 125             


His Ser Val Trp Lys Asp Leu Leu Glu Asp Thr Val Thr Pro Ile Asp 
    130                 135                 140                 


Thr Thr Ile Met Ala Lys Asn Glu Val Phe Cys Val Gln Pro Glu Lys 
145                 150                 155                 160 


Gly Gly Arg Lys Pro Ala Arg Leu Ile Val Phe Pro Asp Leu Gly Val 
                165                 170                 175     


Arg Val Cys Glu Lys Met Ala Leu Tyr Asp Val Val Ser Thr Leu Pro 
            180                 185                 190         


Gln Val Val Met Gly Ser Ser Tyr Gly Phe Gln Tyr Ser Pro Gly Gln 
        195                 200                 205             


Arg Val Glu Phe Leu Val Asn Thr Trp Lys Ser Lys Lys Asn Pro Met 
    210                 215                 220                 


Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp Ser Thr Val Thr Glu Asn 
225                 230                 235                 240 


Asp Ile Arg Val Glu Glu Ser Ile Tyr Gln Cys Cys Asp Leu Ala Pro 
                245                 250                 255     


Glu Ala Arg Gln Ala Ile Lys Ser Leu Thr Glu Arg Leu Tyr Ile Gly 
            260                 265                 270         


Gly Pro Leu Thr Asn Ser Lys Gly Gln Asn Cys Gly Tyr Arg Arg Cys 
        275                 280                 285             


Arg Ala Thr Gly Val Leu Thr Thr Ser Cys Gly Asn Thr Leu Thr Cys 
    290                 295                 300                 


Tyr Leu Lys Ala Ser Ala Ala Cys Arg Ala Ala Lys Leu Gln Asp Cys 
305                 310                 315                 320 


Thr Met Leu Val Asn Gly Asp Asp Leu Val Val Ile Cys Glu Ser Ala 
                325                 330                 335     


Gly Thr Gln Glu Asp Ala Ala Ser Leu Arg Val Phe Thr Glu Ala Met 
            340                 345                 350         


Thr Arg Tyr Ser Ala Pro Pro Gly Asp Pro Pro Gln Pro Glu Tyr Asp 
        355                 360                 365             


Leu Glu Leu Ile Thr Ser Cys Ser Ser Asn Val Ser Val Ala His Asp 
    370                 375                 380                 


Ala Ser Gly Lys Arg Val Tyr Tyr Leu Thr Arg Asp Pro Thr Thr Pro 
385                 390                 395                 400 


Leu Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val Asn Ser 
                405                 410                 415     


Trp Leu Gly Asn Ile Ile Met Tyr Ala Pro Thr Leu Trp Ala Arg Met 
            420                 425                 430         


Ile Leu Met Thr His Phe Phe Ser Ile Leu Leu Ala Gln Glu Gln Leu 
        435                 440                 445             


Glu Lys Ala Leu Asp Cys Gln Ile Tyr Gly Ala Cys Tyr Ser Ile Glu 
    450                 455                 460                 


Pro Leu Asp Leu Pro Gln Ile Ile Glu Arg Leu His Gly Leu Ser Ala 
465                 470                 475                 480 


Phe Ser Leu His Ser Tyr Ser Pro Gly Glu Ile Asn Arg Val Ala Ser 
                485                 490                 495     


Cys Leu Arg Lys Leu Gly Val Pro Pro Leu Arg Val Trp Arg His Arg 
            500                 505                 510         


Ala Arg Ser Val Arg Ala Arg Leu Leu Ser Gln Gly Gly Arg Ala Ala 
        515                 520                 525             


Thr Cys Gly Lys Tyr Leu Phe Asn Trp Ala Val Lys Thr Lys Leu Lys 
    530                 535                 540                 


Leu Thr Pro Ile Pro Ala Ala Ser Gln Leu Asp Leu Ser Gly Trp Phe 
545                 550                 555                 560 


Val Ala Gly Tyr Ser Gly Gly Asp Ile Tyr His Ser Leu Ser Arg Ala 
                565                 570                 575     


Arg Pro Arg 
            


<210>  6
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1b-delta8  His-6[HCV NS5b 1B (BK, QM, delta444-453, GG, C-term 
       delta21)]

<400>  6

Met Ala Ser His His His His His His Ser Met Ser Tyr Thr Trp Thr 
1               5                   10                  15      


Gly Ala Leu Ile Thr Pro Cys Ala Ala Glu Glu Ser Lys Leu Pro Ile 
            20                  25                  30          


Asn Ala Leu Ser Asn Ser Leu Leu Arg His His Asn Met Val Tyr Ala 
        35                  40                  45              


Thr Thr Ser Arg Ser Ala Gly Gln Arg Gln Lys Lys Val Thr Phe Asp 
    50                  55                  60                  


Arg Leu Gln Val Leu Asp Asp His Tyr Arg Asp Val Leu Lys Glu Met 
65                  70                  75                  80  


Lys Ala Lys Ala Ser Thr Val Lys Ala Lys Leu Leu Ser Val Gln Gln 
                85                  90                  95      


Ala Cys Lys Leu Thr Pro Pro His Ser Ala Lys Ser Lys Phe Gly Tyr 
            100                 105                 110         


Gly Ala Lys Asp Val Arg Asn Leu Ser Ser Arg Ala Val Asn His Ile 
        115                 120                 125             


His Ser Val Trp Lys Asp Leu Leu Glu Asp Thr Val Thr Pro Ile Asp 
    130                 135                 140                 


Thr Thr Ile Met Ala Lys Asn Glu Val Phe Cys Val Gln Pro Glu Lys 
145                 150                 155                 160 


Gly Gly Arg Lys Pro Ala Arg Leu Ile Val Phe Pro Asp Leu Gly Val 
                165                 170                 175     


Arg Val Cys Glu Lys Met Ala Leu Tyr Asp Val Val Ser Thr Leu Pro 
            180                 185                 190         


Gln Val Val Met Gly Ser Ser Tyr Gly Phe Gln Tyr Ser Pro Gly Gln 
        195                 200                 205             


Arg Val Glu Phe Leu Val Asn Thr Trp Lys Ser Lys Lys Asn Pro Met 
    210                 215                 220                 


Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp Ser Thr Val Thr Glu Asn 
225                 230                 235                 240 


Asp Ile Arg Val Glu Glu Ser Ile Tyr Gln Cys Cys Asp Leu Ala Pro 
                245                 250                 255     


Glu Ala Arg Gln Ala Ile Lys Ser Leu Thr Glu Arg Leu Tyr Ile Gly 
            260                 265                 270         


Gly Pro Leu Thr Asn Ser Lys Gly Gln Asn Cys Gly Tyr Arg Arg Cys 
        275                 280                 285             


Arg Ala Ser Gly Val Leu Thr Thr Ser Cys Gly Asn Thr Leu Thr Cys 
    290                 295                 300                 


Tyr Leu Lys Ala Ser Ala Ala Cys Arg Ala Ala Lys Leu Gln Asp Cys 
305                 310                 315                 320 


Thr Met Leu Val Asn Gly Asp Asp Leu Val Val Ile Cys Glu Ser Ala 
                325                 330                 335     


Gly Thr Gln Glu Asp Ala Ala Ser Leu Arg Val Phe Thr Glu Ala Met 
            340                 345                 350         


Thr Arg Tyr Ser Ala Pro Pro Gly Asp Pro Pro Gln Pro Glu Tyr Asp 
        355                 360                 365             


Leu Glu Leu Ile Thr Ser Cys Ser Ser Asn Val Ser Val Ala His Asp 
    370                 375                 380                 


Ala Ser Gly Lys Arg Val Tyr Tyr Leu Thr Arg Asp Pro Thr Thr Pro 
385                 390                 395                 400 


Leu Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val Asn Ser 
                405                 410                 415     


Trp Leu Gly Asn Ile Ile Met Tyr Ala Pro Thr Leu Trp Ala Arg Met 
            420                 425                 430         


Ile Leu Met Thr His Phe Phe Ser Ile Leu Leu Ala Gln Glu Gln Leu 
        435                 440                 445             


Glu Lys Ala Leu Gly Gly Ile Glu Pro Leu Asp Leu Pro Gln Ile Ile 
    450                 455                 460                 


Glu Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro 
465                 470                 475                 480 


Gly Glu Ile Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly Val Pro 
                485                 490                 495     


Pro Leu Arg Val Trp Arg His Arg Ala Arg Ser Val Arg Ala Arg Leu 
            500                 505                 510         


Leu Ser Gln Gly Gly Arg Ala Ala Thr Cys Gly Lys Tyr Leu Phe Asn 
        515                 520                 525             


Trp Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Ile Pro Ala Ala Ser 
    530                 535                 540                 


Gln Leu Asp Leu Ser Gly Trp Phe Val Ala Gly Tyr Ser Gly Gly Asp 
545                 550                 555                 560 


Ile Tyr His Ser Leu Ser Arg Ala Arg Pro Arg 
                565                 570     


<210>  7
<211>  571
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1b-delta8 S282T  His-6[HCV NS5b 1B (BK, QM, delta444-453, GG, 
       C-term delta21)]

<400>  7

Met Ala Ser His His His His His His Ser Met Ser Tyr Thr Trp Thr 
1               5                   10                  15      


Gly Ala Leu Ile Thr Pro Cys Ala Ala Glu Glu Ser Lys Leu Pro Ile 
            20                  25                  30          


Asn Ala Leu Ser Asn Ser Leu Leu Arg His His Asn Met Val Tyr Ala 
        35                  40                  45              


Thr Thr Ser Arg Ser Ala Gly Gln Arg Gln Lys Lys Val Thr Phe Asp 
    50                  55                  60                  


Arg Leu Gln Val Leu Asp Asp His Tyr Arg Asp Val Leu Lys Glu Met 
65                  70                  75                  80  


Lys Ala Lys Ala Ser Thr Val Lys Ala Lys Leu Leu Ser Val Gln Gln 
                85                  90                  95      


Ala Cys Lys Leu Thr Pro Pro His Ser Ala Lys Ser Lys Phe Gly Tyr 
            100                 105                 110         


Gly Ala Lys Asp Val Arg Asn Leu Ser Ser Arg Ala Val Asn His Ile 
        115                 120                 125             


His Ser Val Trp Lys Asp Leu Leu Glu Asp Thr Val Thr Pro Ile Asp 
    130                 135                 140                 


Thr Thr Ile Met Ala Lys Asn Glu Val Phe Cys Val Gln Pro Glu Lys 
145                 150                 155                 160 


Gly Gly Arg Lys Pro Ala Arg Leu Ile Val Phe Pro Asp Leu Gly Val 
                165                 170                 175     


Arg Val Cys Glu Lys Met Ala Leu Tyr Asp Val Val Ser Thr Leu Pro 
            180                 185                 190         


Gln Val Val Met Gly Ser Ser Tyr Gly Phe Gln Tyr Ser Pro Gly Gln 
        195                 200                 205             


Arg Val Glu Phe Leu Val Asn Thr Trp Lys Ser Lys Lys Asn Pro Met 
    210                 215                 220                 


Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp Ser Thr Val Thr Glu Asn 
225                 230                 235                 240 


Asp Ile Arg Val Glu Glu Ser Ile Tyr Gln Cys Cys Asp Leu Ala Pro 
                245                 250                 255     


Glu Ala Arg Gln Ala Ile Lys Ser Leu Thr Glu Arg Leu Tyr Ile Gly 
            260                 265                 270         


Gly Pro Leu Thr Asn Ser Lys Gly Gln Asn Cys Gly Tyr Arg Arg Cys 
        275                 280                 285             


Arg Ala Thr Gly Val Leu Thr Thr Ser Cys Gly Asn Thr Leu Thr Cys 
    290                 295                 300                 


Tyr Leu Lys Ala Ser Ala Ala Cys Arg Ala Ala Lys Leu Gln Asp Cys 
305                 310                 315                 320 


Thr Met Leu Val Asn Gly Asp Asp Leu Val Val Ile Cys Glu Ser Ala 
                325                 330                 335     


Gly Thr Gln Glu Asp Ala Ala Ser Leu Arg Val Phe Thr Glu Ala Met 
            340                 345                 350         


Thr Arg Tyr Ser Ala Pro Pro Gly Asp Pro Pro Gln Pro Glu Tyr Asp 
        355                 360                 365             


Leu Glu Leu Ile Thr Ser Cys Ser Ser Asn Val Ser Val Ala His Asp 
    370                 375                 380                 


Ala Ser Gly Lys Arg Val Tyr Tyr Leu Thr Arg Asp Pro Thr Thr Pro 
385                 390                 395                 400 


Leu Ala Arg Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val Asn Ser 
                405                 410                 415     


Trp Leu Gly Asn Ile Ile Met Tyr Ala Pro Thr Leu Trp Ala Arg Met 
            420                 425                 430         


Ile Leu Met Thr His Phe Phe Ser Ile Leu Leu Ala Gln Glu Gln Leu 
        435                 440                 445             


Glu Lys Ala Leu Gly Gly Ile Glu Pro Leu Asp Leu Pro Gln Ile Ile 
    450                 455                 460                 


Glu Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro 
465                 470                 475                 480 


Gly Glu Ile Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly Val Pro 
                485                 490                 495     


Pro Leu Arg Val Trp Arg His Arg Ala Arg Ser Val Arg Ala Arg Leu 
            500                 505                 510         


Leu Ser Gln Gly Gly Arg Ala Ala Thr Cys Gly Lys Tyr Leu Phe Asn 
        515                 520                 525             


Trp Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Ile Pro Ala Ala Ser 
    530                 535                 540                 


Gln Leu Asp Leu Ser Gly Trp Phe Val Ala Gly Tyr Ser Gly Gly Asp 
545                 550                 555                 560 


Ile Tyr His Ser Leu Ser Arg Ala Arg Pro Arg 
                565                 570     


<210>  8
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2a-delta8  [HCV NS5b 2a (1-565, WT, E86Q, E87Q, delta8)]His-6

<400>  8

Met Ser Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys 
1               5                   10                  15      


Ser Pro Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu 
            20                  25                  30          


Leu Arg Tyr His Asn Lys Val Tyr Cys Thr Thr Ser Lys Ser Ala Ser 
        35                  40                  45              


Gln Arg Ala Lys Lys Val Thr Phe Asp Arg Thr Gln Val Leu Asp Ala 
    50                  55                  60                  


His Tyr Asp Ser Val Leu Lys Leu Ala Ala Ser Lys Val Ser Ala Arg 
65                  70                  75                  80  


Leu Leu Thr Leu Gln Gln Ala Cys Gln Leu Thr Pro Pro His Ser Ala 
                85                  90                  95      


Arg Ser Lys Tyr Gly Phe Gly Ala Lys Glu Val Arg Ser Leu Ser Gly 
            100                 105                 110         


Arg Ala Val Asn His Ile Lys Ser Val Trp Lys Asp Leu Leu Glu Asp 
        115                 120                 125             


Pro Gln Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val Phe 
    130                 135                 140                 


Cys Val Asp Pro Ala Lys Gly Gly Lys Lys Pro Ala Arg Leu Ile Val 
145                 150                 155                 160 


Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr Asp 
                165                 170                 175     


Ile Thr Gln Lys Leu Pro Gln Ala Val Met Gly Ala Ser Tyr Gly Phe 
            180                 185                 190         


Gln Tyr Ser Pro Ala Gln Arg Val Glu Tyr Leu Leu Lys Ala Trp Ala 
        195                 200                 205             


Glu Lys Lys Asp Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe Asp 
    210                 215                 220                 


Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Ser Ile Tyr Gln 
225                 230                 235                 240 


Ala Cys Ser Leu Pro Glu Glu Ala Arg Thr Ala Ile His Ser Leu Thr 
                245                 250                 255     


Glu Arg Leu Tyr Val Gly Gly Pro Met Phe Asn Ser Lys Gly Gln Thr 
            260                 265                 270         


Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser Met 
        275                 280                 285             


Gly Asn Thr Ile Thr Cys Tyr Val Lys Ala Leu Ala Ala Cys Lys Ala 
    290                 295                 300                 


Ala Gly Ile Val Ala Pro Thr Met Leu Val Cys Gly Asp Asp Leu Val 
305                 310                 315                 320 


Val Ile Ser Glu Ser Gln Gly Thr Glu Glu Asp Glu Arg Asn Leu Arg 
                325                 330                 335     


Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp Pro 
            340                 345                 350         


Pro Arg Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser Asn 
        355                 360                 365             


Val Ser Val Ala Leu Gly Pro Arg Gly Arg Arg Arg Tyr Tyr Leu Thr 
    370                 375                 380                 


Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Val Arg 
385                 390                 395                 400 


His Ser Pro Ile Asn Ser Trp Leu Gly Asn Ile Ile Gln Tyr Ala Pro 
                405                 410                 415     


Thr Ile Trp Val Arg Met Val Leu Met Thr His Phe Phe Ser Ile Leu 
            420                 425                 430         


Met Val Gln Asp Thr Leu Asp Gln Asn Leu Gly Gly Val Asn Pro Leu 
        435                 440                 445             


Asp Leu Pro Ala Ile Ile Glu Arg Leu His Gly Leu Asp Ala Phe Ser 
    450                 455                 460                 


Met His Thr Tyr Ser His His Glu Leu Thr Arg Val Ala Ser Ala Leu 
465                 470                 475                 480 


Arg Lys Leu Gly Ala Pro Pro Leu Arg Val Trp Lys Ser Arg Ala Arg 
                485                 490                 495     


Ala Val Arg Ala Ser Leu Ile Ser Arg Gly Gly Lys Ala Ala Val Cys 
            500                 505                 510         


Gly Arg Tyr Leu Phe Asn Trp Ala Val Lys Thr Lys Leu Lys Leu Thr 
        515                 520                 525             


Pro Leu Pro Glu Ala Arg Leu Leu Asp Leu Ser Ser Trp Phe Thr Val 
    530                 535                 540                 


Gly Ala Gly Gly Gly Asp Ile Phe His Ser Val Ser Arg Ala Arg Pro 
545                 550                 555                 560 


Arg Leu Glu His His His His His His 
                565                 


<210>  9
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Symmetrical primer-template RNA construct; RNA54; n = 3'-dG


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or u

<400>  9
uaccgn                                                                   6


<210>  10
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Symmetrical primer-template RNA construct; RNA62; n = 2',3'-ddC


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or u

<400>  10
cauggcn                                                                  7


<210>  11
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Symmetrical primer-template RNA construct; RNA27

<400>  11
uacccggg                                                                 8


<210>  12
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Symmetrical primer-template RNA construct; RNA30; n = 3'-dG


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or u

<400>  12
uacccggn                                                                 8


<210>  13
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Symmetrical primer-template RNA construct; RNA29

<400>  13
uaccccgggg                                                              10


<210>  14
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Symmetrical primer-template RNA construct; RNA32; n = 3'-dG


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or u

<400>  14
uaccccgggn                                                              10


<210>  15
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Fused primer-template hairpin RNA construct; RNA35 (13-mer; 3 bp)

<400>  15
gagcccgaaa ggg                                                          13


<210>  16
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Fused primer-template hairpin RNA construct; RNA37 (17-mer; 5 bp)

<400>  16
gagcccccga aaggggg                                                      17


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Fused primer-template hairpin RNA construct; RNA38 (19-mer; 6 bp)

<400>  17
gagccccccg aaagggggg                                                    19


<210>  18
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Fused primer-template hairpin RNA construct; RNA39 (21-mer; 7 bp)

<400>  18
gagccccccc gaaagggggg g                                                 21


<210>  19
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Fused primer-template hairpin RNA construct; RNA41 (25-mer; 9 bp)

<400>  19
gagccccccc ccgaaagggg ggggg                                             25


<210>  20
<211>  531
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (173)..(173)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (187)..(187)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (215)..(215)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (313)..(313)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (343)..(343)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (414)..(414)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (423)..(423)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (426)..(426)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Ser Xaa Ser Tyr Thr Trp Thr Gly Ala Leu Ile Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Ser Lys Leu Pro Ile Asn Ala Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


His His Asn Xaa Val Tyr Ala Thr Thr Ser Arg Ser Ala Gly Leu Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His Tyr 
    50                  55                  60                  


Arg Asp Val Leu Lys Glu Xaa Lys Ala Lys Ala Ser Thr Val Lys Ala 
65                  70                  75                  80  


Lys Leu Leu Ser Val Glu Glu Ala Cys Lys Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val Arg Asn Leu Ser 
            100                 105                 110         


Ser Lys Ala Val Asn His Ile His Ser Val Trp Lys Asp Leu Leu Glu 
        115                 120                 125             


Asp Thr Val Thr Pro Ile Asp Thr Thr Ile Xaa Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Gln Pro Glu Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Phe Pro Asp Leu Gly Val Arg Val Cys Glu Lys Xaa Ala Leu Tyr 
                165                 170                 175     


Asp Val Val Ser Thr Leu Pro Gln Val Val Xaa Gly Ser Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Gly Gln Arg Val Glu Phe Leu Val Asn Thr Trp 
        195                 200                 205             


Lys Ser Lys Lys Asn Pro Xaa Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Asn Asp Ile Arg Val Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Gln Cys Cys Asp Leu Ala Pro Glu Ala Arg Gln Ala Ile Lys Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Ile Gly Gly Pro Leu Thr Asn Ser Lys Gly Gln 
            260                 265                 270         


Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Cys Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Ser Ala Ala Cys Arg 
    290                 295                 300                 


Ala Ala Lys Leu Gln Asp Cys Thr Xaa Leu Val Asn Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Cys Glu Ser Ala Gly Thr Gln Glu Asp Ala Ala Ser Leu 
                325                 330                 335     


Arg Val Phe Thr Glu Ala Xaa Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Ala Ser Gly Lys Arg Val Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Xaa Tyr Ala 
                405                 410                 415     


Pro Thr Leu Trp Ala Arg Xaa Ile Leu Xaa Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Leu Ala Gln Glu Gln Leu Glu Lys Ala Leu Asp Cys Gln Ile Tyr 
        435                 440                 445             


Gly Ala Cys Tyr Ser Ile Glu Pro Leu Asp Leu Pro Gln Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro Gly 
465                 470                 475                 480 


Glu Ile Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly Val Pro Pro 
                485                 490                 495     


Leu Arg Val Trp Arg His Arg Ala Arg Ser Val Arg Ala Arg Leu Leu 
            500                 505                 510         


Ser Gln Gly Gly Arg Ala Ala Thr Cys Gly Lys Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys 
    530     


<210>  21
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  21

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Val Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Gln Lys Leu Pro Ile Asn Ala Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


His His Asn Leu Val Tyr Ser Thr Thr Ser Arg Ser Ala Cys Gln Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Ser His Tyr 
    50                  55                  60                  


Gln Asp Val Leu Lys Glu Val Lys Ala Ala Ala Ser Lys Val Lys Ala 
65                  70                  75                  80  


Asn Leu Leu Ser Val Glu Glu Ala Cys Ser Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val Arg Cys His Ala 
            100                 105                 110         


Arg Lys Ala Val Thr His Ile Asn Ser Val Trp Lys Asp Leu Leu Glu 
        115                 120                 125             


Asp Asn Val Thr Pro Ile Asp Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Gln Pro Glu Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Phe Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Val Val Thr Lys Leu Pro Leu Ala Val Met Gly Ser Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Gly Gln Arg Val Glu Phe Leu Val Gln Ala Trp 
        195                 200                 205             


Lys Ser Lys Lys Thr Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Ser Asp Ile Arg Thr Glu Glu Ala Ile Tyr 
225                 230                 235                 240 


Gln Cys Cys Asp Leu Asp Pro Gln Ala Arg Val Ala Ile Lys Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Val Gly Gly Pro Leu Thr Asn Ser Arg Gly Glu 
            260                 265                 270         


Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Cys Gly Asn Thr Leu Thr Cys Tyr Ile Lys Ala Arg Ala Ala Cys Arg 
    290                 295                 300                 


Ala Ala Gly Leu Gln Asp Cys Thr Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Cys Glu Ser Ala Gly Val Gln Glu Asp Ala Ala Ser Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Gly Ala Gly Lys Arg Val Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Phe Ala 
                405                 410                 415     


Pro Thr Leu Trp Ala Arg Met Ile Leu Met Thr His Phe Phe Ser Val 
            420                 425                 430         


Leu Ile Ala Arg Asp Gln Leu Glu Gln Ala Leu Asp Cys Glu Ile Tyr 
        435                 440                 445             


Gly Ala Cys Tyr Ser Ile Glu Pro Leu Asp Leu Pro Pro Ile Ile Gln 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro Gly 
465                 470                 475                 480 


Glu Ile Asn Arg Val Ala Ala Cys Leu Arg Lys Leu Gly Val Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ser Val Arg Ala Arg Leu Leu 
            500                 505                 510         


Ala Arg Gly Gly Arg Ala Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Arg Thr Lys Leu Lys Leu Thr Pro Ile Ala Ala Ala Gly Gln 
    530                 535                 540                 


Leu Asp Leu Ser Gly Trp Phe Thr Ala Gly Tyr Ser Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser His Ala Arg Pro Arg Trp Ile Trp Phe Cys Leu 
                565                 570                 575     


Leu Leu Leu Ala Ala Gly Val Gly Ile Tyr Leu Leu Pro Asn Arg 
            580                 585                 590     


<210>  22
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  22

Ser Met Ser Tyr Thr Trp Thr Gly Ala Leu Ile Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Ser Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


His His Asn Met Val Tyr Ala Thr Thr Ser Arg Ser Ala Ser Leu Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His Tyr 
    50                  55                  60                  


Arg Asp Val Leu Lys Glu Met Lys Ala Lys Ala Ser Thr Val Lys Ala 
65                  70                  75                  80  


Lys Leu Leu Ser Ile Glu Glu Ala Cys Lys Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val Arg Asn Leu Ser 
            100                 105                 110         


Ser Arg Ala Val Asn His Ile Arg Ser Val Trp Glu Asp Leu Leu Glu 
        115                 120                 125             


Asp Thr Glu Thr Pro Ile Asp Thr Thr Ile Met Ala Lys Ser Glu Val 
    130                 135                 140                 


Phe Cys Val Gln Pro Glu Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Phe Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Val Val Ser Thr Leu Pro Gln Ala Val Met Gly Ser Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Lys Gln Arg Val Glu Phe Leu Val Asn Thr Trp 
        195                 200                 205             


Lys Ser Lys Lys Cys Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Ser Asp Ile Arg Val Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Gln Cys Cys Asp Leu Ala Pro Glu Ala Arg Gln Ala Ile Arg Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Ile Gly Gly Pro Leu Thr Asn Ser Lys Gly Gln 
            260                 265                 270         


Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Cys Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Thr Ala Ala Cys Arg 
    290                 295                 300                 


Ala Ala Lys Leu Gln Asp Cys Thr Met Leu Val Asn Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Cys Glu Ser Ala Gly Thr Gln Glu Asp Ala Ala Ala Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Ala Ser Gly Lys Arg Val Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Ile Asn Ser Trp Leu Gly Asn Ile Ile Met Tyr Ala 
                405                 410                 415     


Pro Thr Leu Trp Ala Arg Met Ile Leu Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Leu Ala Gln Glu Gln Leu Glu Lys Ala Leu Asp Cys Gln Ile Tyr 
        435                 440                 445             


Gly Ala Cys Tyr Ser Ile Glu Pro Leu Asp Leu Pro Gln Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Thr Leu His Ser Tyr Ser Pro Gly 
465                 470                 475                 480 


Glu Ile Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly Val Pro Pro 
                485                 490                 495     


Leu Arg Thr Trp Arg His Arg Ala Arg Ser Val Arg Ala Lys Leu Leu 
            500                 505                 510         


Ser Gln Gly Gly Arg Ala Ala Thr Cys Gly Arg Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Arg Thr Lys Leu Lys Leu Thr Pro Ile Pro Ala Ala Ser Gln 
    530                 535                 540                 


Leu Asp Leu Ser Gly Trp Phe Val Ala Gly Tyr Ser Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Leu Ser Arg Ala Arg Pro Arg Trp Phe Pro Leu Cys Leu 
                565                 570                 575     


Leu Leu Leu Ser Val Gly Val Gly Ile Tyr Leu Leu Pro Asn Arg 
            580                 585                 590     


<210>  23
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  23

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Thr Lys Leu Pro Ile Asn Ala Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


His His Asn Leu Val Tyr Ser Thr Thr Ser Arg Ser Ala Gly Gln Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His Tyr 
    50                  55                  60                  


Arg Asp Val Leu Lys Glu Ala Lys Ala Lys Ala Ser Thr Val Lys Ala 
65                  70                  75                  80  


Lys Leu Leu Ser Val Glu Glu Ala Cys Ser Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val Arg Ser His Ser 
            100                 105                 110         


Ser Lys Ala Ile Arg His Ile Asn Ser Val Trp Gln Asp Leu Leu Glu 
        115                 120                 125             


Asp Asn Thr Thr Pro Ile Asp Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Lys Pro Glu Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Arg Ala Leu Tyr 
                165                 170                 175     


Asp Val Val Lys Gln Leu Pro Ile Ala Val Met Gly Thr Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Ala Gln Arg Val Asp Phe Leu Leu Asn Ala Trp 
        195                 200                 205             


Lys Ser Lys Lys Asn Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Ala Asp Ile Arg Thr Glu Glu Asp Leu Tyr 
225                 230                 235                 240 


Gln Ser Cys Asp Leu Val Pro Glu Ala Arg Ala Ala Ile Arg Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Ile Gly Gly Pro Leu Thr Asn Ser Lys Gly Gln 
            260                 265                 270         


Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Cys Gly Asn Thr Ile Thr Cys Tyr Leu Lys Ala Ser Ala Ala Cys Arg 
    290                 295                 300                 


Ala Ala Lys Leu Arg Asp Cys Thr Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Cys Glu Ser Ala Gly Val Gln Glu Asp Ala Ala Asn Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Gly Ala Gly Lys Arg Val Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Glu Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Phe Ala 
                405                 410                 415     


Pro Thr Leu Trp Val Arg Met Val Leu Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Ile Ala Gln Glu His Leu Glu Lys Ala Leu Asp Cys Glu Ile Tyr 
        435                 440                 445             


Gly Ala Val His Ser Val Gln Pro Leu Asp Leu Pro Glu Ile Ile Gln 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro Gly 
465                 470                 475                 480 


Glu Ile Asn Arg Val Ala Ala Cys Leu Arg Lys Leu Gly Val Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ser Val Arg Ala Thr Leu Leu 
            500                 505                 510         


Ser Gln Gly Gly Arg Ala Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Leu Pro Ser Ala Ser Gln 
    530                 535                 540                 


Leu Asp Leu Ser Asn Trp Phe Thr Gly Gly Tyr Ser Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser His Val Arg Pro Arg Trp Phe Phe Trp Cys Leu 
                565                 570                 575     


Leu Leu Leu Ser Val Gly Val Gly Ile Tyr Leu Leu Pro Asn Arg 
            580                 585                 590     


<210>  24
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  24

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ser Pro 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


Tyr His Asn Lys Val Tyr Cys Thr Thr Ser Lys Ser Ala Ser Leu Arg 
        35                  40                  45              


Ala Lys Lys Val Thr Phe Asp Arg Met Gln Ala Leu Asp Ala His Tyr 
    50                  55                  60                  


Asp Ser Val Leu Lys Asp Ile Lys Leu Ala Ala Ser Lys Val Thr Ala 
65                  70                  75                  80  


Arg Leu Leu Thr Leu Glu Glu Ala Cys Gln Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Lys Tyr Gly Phe Gly Ala Lys Glu Val Arg Ser Leu Ser 
            100                 105                 110         


Gly Arg Ala Val Asn His Ile Lys Ser Val Trp Lys Asp Leu Leu Glu 
        115                 120                 125             


Asp Thr Gln Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Asp Pro Thr Lys Gly Gly Lys Lys Ala Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Ile Thr Gln Lys Leu Pro Gln Ala Val Met Gly Ala Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Ala Gln Arg Val Glu Phe Leu Leu Lys Ala Trp 
        195                 200                 205             


Ala Glu Lys Lys Asp Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Arg Ala Cys Ser Leu Pro Glu Glu Ala His Thr Ala Ile His Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Val Gly Gly Pro Met Phe Asn Ser Lys Gly Gln 
            260                 265                 270         


Thr Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Met Gly Asn Thr Ile Thr Cys Tyr Val Lys Ala Leu Ala Ala Cys Lys 
    290                 295                 300                 


Ala Ala Gly Ile Ile Ala Pro Thr Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Ser Glu Ser Gln Gly Thr Glu Glu Asp Glu Arg Asn Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Arg Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala Leu Gly Pro Gln Gly Arg Arg Arg Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Thr Thr Pro Ile Ala Arg Ala Ala Trp Glu Thr Val 
385                 390                 395                 400 


Arg His Ser Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Gln Tyr Ala 
                405                 410                 415     


Pro Thr Ile Trp Ala Arg Met Val Leu Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Met Ala Gln Asp Thr Leu Asp Gln Asn Leu Asn Phe Glu Met Tyr 
        435                 440                 445             


Gly Ala Val Tyr Ser Val Ser Pro Leu Asp Leu Pro Ala Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Asp Ala Phe Ser Leu His Thr Tyr Thr Pro His 
465                 470                 475                 480 


Glu Leu Thr Arg Val Ala Ser Ala Leu Arg Lys Leu Gly Ala Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Lys Ser Arg Ala Arg Ala Val Arg Ala Ser Leu Ile 
            500                 505                 510         


Ser Arg Gly Gly Arg Ala Ala Val Cys Gly Arg Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Leu Pro Glu Ala Arg Leu 
    530                 535                 540                 


Leu Asp Leu Ser Ser Trp Phe Thr Val Gly Ala Gly Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser Arg Ala Arg Pro Arg Leu Leu Leu Leu Gly Leu 
                565                 570                 575     


Leu Leu Leu Phe Val Gly Val Gly Leu Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  25
<211>  538
<212>  PRT
<213>  Hepatitis C virus

<400>  25

Ser Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ser 
1               5                   10                  15      


Pro Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Leu 
            20                  25                  30          


Arg Tyr His Asn Lys Val Tyr Cys Thr Thr Ser Lys Ser Ala Ser Gln 
        35                  40                  45              


Arg Ala Lys Lys Val Thr Phe Asp Arg Thr Gln Val Leu Asp Ala His 
    50                  55                  60                  


Tyr Asp Ser Val Leu Lys Asp Ile Lys Leu Ala Ala Ser Lys Val Ser 
65                  70                  75                  80  


Ala Arg Leu Leu Thr Leu Gln Gln Ala Cys Gln Leu Thr Pro Pro His 
                85                  90                  95      


Ser Ala Arg Ser Lys Tyr Gly Phe Gly Ala Lys Glu Val Arg Ser Leu 
            100                 105                 110         


Ser Gly Arg Ala Val Asn His Ile Lys Ser Val Trp Lys Asp Leu Leu 
        115                 120                 125             


Glu Asp Pro Gln Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu 
    130                 135                 140                 


Val Phe Cys Val Asp Pro Ala Lys Gly Gly Lys Lys Pro Ala Arg Leu 
145                 150                 155                 160 


Ile Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu 
                165                 170                 175     


Tyr Asp Ile Thr Gln Lys Leu Pro Gln Ala Val Met Gly Ala Ser Tyr 
            180                 185                 190         


Gly Phe Gln Tyr Ser Pro Ala Gln Arg Val Glu Tyr Leu Leu Lys Ala 
        195                 200                 205             


Trp Ala Glu Lys Lys Asp Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys 
    210                 215                 220                 


Phe Asp Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Ser Ile 
225                 230                 235                 240 


Tyr Gln Ala Cys Ser Leu Pro Glu Glu Ala Arg Thr Ala Ile His Ser 
                245                 250                 255     


Leu Thr Glu Arg Leu Tyr Val Gly Gly Pro Met Phe Asn Ser Lys Gly 
            260                 265                 270         


Gln Thr Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr 
        275                 280                 285             


Ser Met Gly Asn Thr Ile Thr Cys Tyr Val Lys Ala Leu Ala Ala Cys 
    290                 295                 300                 


Lys Ala Ala Gly Ile Val Ala Pro Thr Met Leu Val Cys Gly Asp Asp 
305                 310                 315                 320 


Leu Val Val Ile Ser Glu Ser Gln Gly Thr Glu Glu Asp Glu Arg Asn 
                325                 330                 335     


Leu Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly 
            340                 345                 350         


Asp Pro Pro Arg Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser 
        355                 360                 365             


Ser Asn Val Ser Val Ala Leu Gly Pro Arg Gly Arg Arg Arg Tyr Tyr 
    370                 375                 380                 


Leu Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr 
385                 390                 395                 400 


Val Arg His Ser Pro Ile Asn Ser Trp Leu Gly Asn Ile Ile Gln Tyr 
                405                 410                 415     


Ala Pro Thr Ile Trp Val Arg Met Val Leu Met Thr His Phe Phe Ser 
            420                 425                 430         


Ile Leu Met Val Gln Asp Thr Leu Asp Gln Asn Leu Gly Gly Val Asn 
        435                 440                 445             


Pro Leu Asp Leu Pro Ala Ile Ile Glu Arg Leu His Gly Leu Asp Ala 
    450                 455                 460                 


Phe Ser Met His Thr Tyr Ser His His Glu Leu Thr Arg Val Ala Ser 
465                 470                 475                 480 


Ala Leu Arg Lys Leu Gly Ala Pro Pro Leu Arg Val Trp Lys Ser Arg 
                485                 490                 495     


Ala Arg Ala Val Arg Ala Ser Leu Ile Ser Arg Gly Gly Lys Ala Ala 
            500                 505                 510         


Val Cys Gly Arg Tyr Leu Phe Asn Trp Ala Val Lys Thr Lys Leu Lys 
        515                 520                 525             


Leu Thr Pro Leu Pro Glu Ala Arg Leu Leu 
    530                 535             


<210>  26
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  26

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Gly Pro 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Ser Pro Leu Ser Asn Ser Leu Met Arg 
            20                  25                  30          


Phe His Asn Lys Val Tyr Ser Thr Thr Ser Arg Ser Ala Ser Leu Arg 
        35                  40                  45              


Ala Lys Lys Val Thr Phe Asp Arg Val Gln Val Leu Asp Ala His Tyr 
    50                  55                  60                  


Asp Ser Val Leu Gln Asp Val Lys Arg Ala Ala Ser Lys Val Ser Ala 
65                  70                  75                  80  


Arg Leu Leu Ser Val Glu Glu Ala Cys Ala Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Lys Ser Arg Tyr Gly Phe Gly Ala Lys Glu Val Arg Ser Leu Ser 
            100                 105                 110         


Arg Gly Ala Val Asn His Ile Arg Ser Val Trp Glu Asp Leu Leu Glu 
        115                 120                 125             


Asp Gln His Thr Pro Ile Asp Thr Thr Ala Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Ile Asp Pro Ala Lys Gly Gly Lys Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Ile Ala Gln Lys Leu Pro Lys Ala Ile Met Gly Pro Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Ala Glu Arg Val Asp Phe Leu Leu Lys Ala Trp 
        195                 200                 205             


Gly Ser Lys Lys Asp Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Gln Ala Cys Ser Leu Pro Gln Glu Ala Arg Thr Val Ile His Ser Ile 
                245                 250                 255     


Thr Glu Arg Leu Tyr Val Gly Gly Pro Met Thr Asn Ser Lys Gly Gln 
            260                 265                 270         


Ser Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Phe Thr Thr Ser 
        275                 280                 285             


Met Gly Asn Thr Met Thr Cys Tyr Ile Lys Ala Leu Ala Ala Cys Lys 
    290                 295                 300                 


Ala Ala Gly Ile Val Asp Pro Thr Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Ser Glu Ser Gln Gly Asn Glu Glu Asp Glu Arg Asn Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Leu Pro Arg Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala Leu Asp Ser Arg Gly Arg Arg Arg Tyr Phe Leu 
    370                 375                 380                 


Thr Arg Asp Pro Thr Thr Pro Ile Thr Arg Ala Ala Trp Glu Thr Val 
385                 390                 395                 400 


Arg His Ser Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Gln Tyr Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Val Ile Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Leu Ala Gln Asp Thr Leu Asn Gln Asn Leu Asn Phe Glu Met Tyr 
        435                 440                 445             


Gly Ala Val Tyr Ser Val Asn Pro Leu Asp Leu Pro Ala Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Asp Ala Phe Ser Leu His Thr Tyr Ser Pro His 
465                 470                 475                 480 


Glu Leu Ser Arg Val Ala Ala Thr Leu Arg Lys Leu Gly Ala Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Lys Ser Arg Ala Arg Ala Val Arg Ala Ser Leu Ile 
            500                 505                 510         


Ile Gln Gly Gly Arg Ala Ala Thr Cys Gly Arg Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Leu Pro Glu Ala Ser Arg 
    530                 535                 540                 


Leu Asp Leu Ser Gly Trp Phe Thr Val Gly Ala Gly Gly Gly Asp Ile 
545                 550                 555                 560 


Phe His Ser Val Ser His Ala Arg Pro Arg Leu Leu Leu Leu Cys Leu 
                565                 570                 575     


Leu Leu Leu Ser Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  27
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  27

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ser Pro 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


Tyr His Asn Lys Val Tyr Cys Thr Thr Ser Arg Ser Ala Ser Gln Arg 
        35                  40                  45              


Ala Lys Lys Val Thr Phe Asp Arg Val Gln Leu Leu Asp Ser His Tyr 
    50                  55                  60                  


Glu Ser Val Leu Lys Asp Val Lys Gln Ala Ala Thr Lys Val Ser Ala 
65                  70                  75                  80  


Lys Leu Leu Ser Ile Glu Glu Ala Cys Ala Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Lys Tyr Gly Phe Gly Ala Lys Glu Val Arg Ser Leu Ser 
            100                 105                 110         


Arg Arg Ala Val Asp His Ile Lys Ser Val Trp Glu Asp Leu Leu Glu 
        115                 120                 125             


Asp His Cys Ser Pro Ile Asp Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Asp Pro Thr Lys Gly Gly Lys Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Ile Thr Gln Lys Leu Pro Val Ala Val Met Gly Gln Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Ala Gln Arg Val Asp Phe Leu Leu Gln Ala Trp 
        195                 200                 205             


Lys Glu Lys Lys Thr Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Leu Ser Cys Ser Leu Pro Glu Glu Ala Arg Thr Ala Ile His Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Val Gly Gly Pro Met Thr Asn Ser Lys Gly Gln 
            260                 265                 270         


Ser Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Met Gly Asn Thr Leu Thr Cys Tyr Val Lys Ala Lys Ala Ala Cys Asn 
    290                 295                 300                 


Ala Ala Gly Ile Val Ala Pro Thr Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Ser Glu Ser Gln Gly Val Glu Glu Asp Glu Arg Asn Leu 
                325                 330                 335     


Arg Val Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Lys Ala Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala Leu Asp Pro Arg Gly Arg Arg Arg Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Ser Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Gln Tyr Ala 
                405                 410                 415     


Pro Thr Val Trp Val Arg Met Val Leu Met Thr His Phe Phe Ser Val 
            420                 425                 430         


Leu Met Ala Gln Asp Thr Leu Asp Gln Asp Leu Asn Phe Glu Met Tyr 
        435                 440                 445             


Gly Ala Val Tyr Ser Val Ser Pro Leu Asp Leu Pro Ala Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Glu Ala Phe Ser Leu His Ser Tyr Ser Pro His 
465                 470                 475                 480 


Glu Leu Thr Arg Val Ala Ala Ala Leu Arg Lys Leu Gly Ala Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Lys Ser Arg Ala Arg Ala Val Arg Ala Ser Leu Ile 
            500                 505                 510         


Ser Arg Gly Gly Ser Ala Ala Thr Cys Gly Arg Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Arg Thr Lys Leu Lys Leu Thr Pro Leu Pro Ala Ala Arg Leu 
    530                 535                 540                 


Leu Asp Leu Ser Ser Trp Phe Thr Val Ser Ala Gly Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser Arg Ala Arg Pro Arg Leu Leu Leu Leu Gly Leu 
                565                 570                 575     


Leu Leu Leu Cys Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  28
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  28

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Gly Pro 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


Tyr His Asn Lys Val Tyr Ser Thr Thr Ser Arg Ser Ala Ser Gln Arg 
        35                  40                  45              


Ala Lys Lys Val Thr Phe Asp Arg Val Gln Leu Leu Asp Ser His Tyr 
    50                  55                  60                  


Asp Gln Val Leu Lys Asp Ile Lys Leu Ala Ala Ser Lys Val Ser Ala 
65                  70                  75                  80  


Asn Leu Leu Ser Ile Glu Glu Ala Cys Ala Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Lys Tyr Gly Phe Gly Ala Lys Glu Val Arg Ser Leu Ser 
            100                 105                 110         


Arg Lys Ala Val Asp His Ile Lys Ser Val Trp Lys Asp Leu Leu Glu 
        115                 120                 125             


Asp Gln Gln Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Ile Asp Pro Thr Lys Gly Gly Lys Lys Ala Ala Arg Leu Ile 
145                 150                 155                 160 


Val Phe Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Ile Thr Gln Lys Leu Pro Gln Ala Val Met Gly Ala Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Ala Gln Arg Val Asp Phe Leu Leu Arg Ala Trp 
        195                 200                 205             


Lys Glu Lys Lys Asp Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Leu Ala Cys Ser Leu Pro Glu Glu Ala Arg Val Ala Ile His Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Val Gly Gly Pro Met Met Asn Ser Lys Gly Gln 
            260                 265                 270         


Ser Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Met Gly Asn Thr Ile Thr Cys Tyr Val Lys Ala Leu Ala Ala Cys Lys 
    290                 295                 300                 


Ala Ala Gly Ile Val Ala Pro Thr Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Ser Glu Ser Gln Gly Ala Glu Glu Asp Glu Arg Asn Leu 
                325                 330                 335     


Arg Val Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Lys Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala Leu Asp Gln His Gly Arg Arg Met Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Ser Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Ser Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Gln Tyr Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Val Leu Met Thr His Phe Phe Ser Val 
            420                 425                 430         


Leu Met Ala Gln Glu Thr Leu Asp Gln Asp Leu Asn Phe Glu Met Tyr 
        435                 440                 445             


Gly Ala Val Tyr Ser Val Asn Pro Leu Asp Leu Pro Ala Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Glu Ala Phe Ser Leu His Gly Tyr Ser Pro Thr 
465                 470                 475                 480 


Glu Leu Thr Arg Val Ala Ala Ala Leu Arg Lys Leu Gly Ala Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Lys Ser Arg Ala Arg Ala Val Arg Ala Ser Leu Ile 
            500                 505                 510         


Ser Gln Gly Gly Arg Ala Ala Thr Cys Gly Phe Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Arg Thr Lys Arg Lys Leu Thr Pro Leu Pro Ala Ala Arg Arg 
    530                 535                 540                 


Leu Asp Leu Ser Gly Trp Phe Thr Val Gly Ala Gly Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser Arg Ala Arg Pro Arg Phe Leu Leu Leu Cys Leu 
                565                 570                 575     


Leu Leu Leu Ser Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  29
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  29

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ser Ala 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Ser Pro Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


His His Asn Leu Val Tyr Ser Thr Ser Ser Arg Ser Ala Ser Gln Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His Tyr 
    50                  55                  60                  


Lys Thr Ala Leu Lys Glu Val Lys Glu Arg Ala Ser Arg Val Lys Ala 
65                  70                  75                  80  


Arg Met Leu Thr Ile Glu Glu Ala Cys Ala Leu Val Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Lys Phe Gly Tyr Ser Ala Lys Asp Val Arg Ser Leu Ser 
            100                 105                 110         


Ser Arg Ala Ile Asn Gln Ile Arg Ser Val Trp Glu Asp Leu Leu Glu 
        115                 120                 125             


Asp Thr Thr Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Asp Pro Ala Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Arg Ala Leu Tyr 
                165                 170                 175     


Asp Val Ile Gln Lys Leu Ser Ile Glu Thr Met Gly Pro Ala Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Gln Gln Arg Val Glu Arg Leu Leu Lys Met Trp 
        195                 200                 205             


Thr Ser Lys Lys Thr Pro Leu Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Gln Asp Ile Arg Val Glu Glu Glu Ile Tyr 
225                 230                 235                 240 


Gln Cys Cys Asn Leu Glu Pro Glu Ala Arg Lys Val Ile Ser Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Cys Gly Gly Pro Met Phe Asn Ser Lys Gly Ala 
            260                 265                 270         


Gln Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Pro Thr Ser 
        275                 280                 285             


Phe Gly Asn Thr Ile Thr Cys Tyr Ile Lys Ala Thr Ala Ala Ala Lys 
    290                 295                 300                 


Ala Ala Asn Leu Arg Asn Pro Asp Phe Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Val Ala Glu Ser Asp Gly Val Asp Glu Asp Arg Ala Ala Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Ala Pro Gln Ala Thr Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala Arg Asp Asp Lys Gly Arg Arg Tyr Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Ala Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Tyr Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Val Met Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Gln Ser Gln Glu Ile Leu Asp Arg Pro Leu Asp Phe Glu Met Tyr 
        435                 440                 445             


Gly Ala Thr Tyr Ser Val Thr Pro Leu Asp Leu Pro Ala Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Thr Leu His Ser Tyr Ser Pro Val 
465                 470                 475                 480 


Glu Leu Asn Arg Val Ala Gly Thr Leu Arg Lys Leu Gly Cys Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            500                 505                 510         


Ala Gln Gly Gly Lys Ala Lys Ile Cys Gly Leu Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Arg Thr Lys Thr Asn Leu Thr Pro Leu Pro Ala Ala Gly Gln 
    530                 535                 540                 


Leu Asp Leu Ser Ser Trp Phe Thr Val Gly Val Gly Gly Asn Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser Arg Ala Arg Thr Arg His Leu Leu Leu Cys Leu 
                565                 570                 575     


Leu Leu Leu Thr Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  30
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  30

Ser Met Ser Tyr Ser Trp Thr Gly Ala Ile Ile Thr Pro Cys Ser Ala 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Ser Pro Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


His His Asn Leu Val Tyr Ser Thr Ser Ser Arg Ser Ala Ala Ala Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His Tyr 
    50                  55                  60                  


Lys Asn Val Leu Lys Glu Val Lys Glu Arg Ala Ser Gly Val Lys Gly 
65                  70                  75                  80  


Arg Leu Leu Ser Phe Glu Glu Ala Cys Ser Leu Val Pro Pro His Ser 
                85                  90                  95      


Gly Arg Ser Lys Tyr Gly Tyr Ser Ala Lys Asp Val Arg Ser Leu Ser 
            100                 105                 110         


Ser Lys Ala Met Asn Gln Ile Arg Ser Val Trp Glu Asp Leu Leu Glu 
        115                 120                 125             


Asp Asn Ser Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Ser Val Asn Pro Ala Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Arg Ala Leu Tyr 
                165                 170                 175     


Asp Val Ile Gln Lys Leu Ser Ile Ala Thr Met Gly Pro Ala Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Lys Gln Arg Val Glu His Leu Leu Lys Met Trp 
        195                 200                 205             


Thr Ser Lys Lys Thr Pro Leu Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu His Asp Ile Arg Thr Glu Glu Gly Ile Tyr 
225                 230                 235                 240 


Gln Cys Cys Asp Leu Glu Pro Glu Ala Arg Lys Ala Ile Ser Ala Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Ile Gly Gly Pro Met Tyr Asn Ser Lys Gly Leu 
            260                 265                 270         


Gln Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Pro Thr Ser 
        275                 280                 285             


Phe Gly Asn Thr Ile Thr Cys Tyr Ile Lys Ala Thr Ala Ala Ser Arg 
    290                 295                 300                 


Ala Ala Gly Leu Lys Asn Pro Ser Phe Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Ser Glu Ser Cys Gly Val Glu Glu Asp Arg Thr Ala Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Ala Pro Gln Pro Thr Tyr Asp Leu Glu Leu Ile Ser Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala Cys Asp Gly Ala Gly Lys Arg Tyr Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Glu Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Phe Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Val Leu Ile Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Gln Ala Gln Glu Gln Leu Glu Arg Ala Leu Asp Phe Glu Met Tyr 
        435                 440                 445             


Gly Ala Thr Tyr Ser Val Thr Pro Leu Asp Leu Pro Ala Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Gly Tyr Ser Pro Thr 
465                 470                 475                 480 


Glu Leu Asn Arg Val Ala Gly Ala Leu Arg Lys Leu Gly Ile Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            500                 505                 510         


Ala Gln Gly Gly Lys Ala Arg Ile Cys Gly Leu Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Arg Thr Lys Thr Lys Leu Thr Pro Leu Pro Thr Ala Gly Gln 
    530                 535                 540                 


Leu Asp Leu Ser Ser Trp Phe Thr Val Gly Val Gly Gly Asn Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser Arg Ala Arg Thr Arg His Leu Leu Leu Cys Leu 
                565                 570                 575     


Leu Leu Leu Thr Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  31
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  31

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Ser Pro Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


His His Asn Leu Val Tyr Ser Thr Ser Ser Arg Ser Ala Ala Gln Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His Tyr 
    50                  55                  60                  


Asn Thr Thr Leu Lys Glu Ile Lys Glu Leu Ala Ser Gly Val Lys Ala 
65                  70                  75                  80  


Glu Leu Leu Ser Val Glu Glu Ala Cys Arg Leu Val Pro Ser His Ser 
                85                  90                  95      


Ala Arg Ser Lys Phe Gly Tyr Gly Ala Lys Glu Val Arg Ser Leu Ser 
            100                 105                 110         


Ser Lys Ala Ile Asn His Ile Asn Ser Val Trp Glu Asp Leu Leu Glu 
        115                 120                 125             


Asp Asn Thr Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Ala Val Ala Pro His Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Ile Cys Glu Lys Arg Ala Leu Tyr 
                165                 170                 175     


Asp Val Ile Gln Lys Leu Pro Ser Ala Ile Met Gly Ser Ala Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Lys Gln Arg Val Glu Tyr Leu Leu Lys Met Trp 
        195                 200                 205             


Asn Ser Lys Lys Thr Pro Leu Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Gln Asp Ile Arg Val Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Gln Ala Cys Asp Leu Lys Asp Glu Ala Arg Arg Val Ile Thr Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Cys Gly Gly Pro Met Phe Asn Ser Lys Gly Gln 
            260                 265                 270         


His Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Pro Thr Ser 
        275                 280                 285             


Phe Gly Asn Thr Val Thr Cys Tyr Leu Lys Ala Lys Ala Ala Thr Lys 
    290                 295                 300                 


Ala Ala Gly Ile Lys Asp Pro Ser Phe Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Ala Glu Ser Ala Gly Ile Asp Glu Asp Lys Ser Ala Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Gln Pro Thr Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Gly Ala Gly Lys Arg Tyr Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Glu Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Tyr Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Val Ile Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Gln Ala Gln Glu Gln Leu Glu Lys Ala Leu Asp Phe Glu Met Tyr 
        435                 440                 445             


Gly Ala Val Tyr Ser Val Thr Pro Leu Asp Leu Pro Ala Ile Ile Glu 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro Val 
465                 470                 475                 480 


Glu Leu Asn Arg Val Ala Gly Ala Leu Arg Lys Leu Gly Ile Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            500                 505                 510         


Ser Gln Gly Gly Lys Ala Lys Ile Cys Gly Leu Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Arg Thr Lys Ala Lys Leu Thr Pro Leu Pro Gln Ala Gly Leu 
    530                 535                 540                 


Leu Asp Leu Ser Arg Trp Phe Thr Val Gly Ala Gly Gly Asn Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser Arg Ala Arg Ser Arg His Leu Leu Leu Gly Leu 
                565                 570                 575     


Leu Leu Leu Thr Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  32
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  32

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Val Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Ser Lys Leu Pro Ile Ser Pro Leu Ser Asn Ser Leu Leu Arg 
            20                  25                  30          


His His Asn Met Val Tyr Ala Thr Thr Thr Arg Ser Ala Val Thr Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Val Asp Ser Thr Tyr 
    50                  55                  60                  


Asn Glu Val Leu Lys Glu Ile Lys Ala Arg Ala Ser Arg Val Lys Pro 
65                  70                  75                  80  


Arg Leu Leu Thr Thr Glu Glu Ala Cys Asp Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Lys Phe Gly Tyr Gly Lys Lys Asp Val Arg Ser His Ser 
            100                 105                 110         


Arg Lys Ala Ile Asn His Ile Ser Ser Val Trp Lys Asp Leu Leu Asp 
        115                 120                 125             


Asp Asn Asn Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Ala Val Asn Pro Ala Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Ser Arg Val Cys Glu Lys Arg Ala Leu His 
                165                 170                 175     


Asp Val Ile Lys Lys Thr Ala Leu Ala Val Met Gly Ala Ala Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Ala Gln Arg Val Glu Phe Leu Leu Thr Ala Trp 
        195                 200                 205             


Lys Ser Lys Asn Asp Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Lys Asp Ile Arg Val Glu Glu Glu Val Tyr 
225                 230                 235                 240 


Gln Cys Cys Asp Leu Glu Pro Glu Ala Arg Lys Val Ile Thr Ala Leu 
                245                 250                 255     


Thr Asp Arg Leu Tyr Val Gly Gly Pro Met His Asn Ser Lys Gly Asp 
            260                 265                 270         


Leu Cys Gly Tyr Arg Arg Cys Arg Ala Thr Gly Val Tyr Thr Thr Ser 
        275                 280                 285             


Phe Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Thr Ala Ala Ile Arg 
    290                 295                 300                 


Ala Ala Ala Leu Arg Asp Cys Thr Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Ala Glu Ser Asp Gly Val Glu Glu Asp Asn Arg Ala Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Ala Pro Gln Pro Ala Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Val Thr Gly Lys Lys Val Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Glu Thr Pro Leu Ala Arg Ala Val Trp Glu Thr Val 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Val Tyr Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Ile Leu Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Gln Ser Gln Glu Ala Leu Glu Lys Ala Leu Asp Phe Asp Met Tyr 
        435                 440                 445             


Gly Val Thr Tyr Ser Ile Thr Pro Leu Asp Leu Pro Ala Ile Ile Gln 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Thr Leu His Gly Tyr Ser Pro His 
465                 470                 475                 480 


Glu Leu Asn Arg Val Ala Gly Ala Leu Arg Lys Leu Gly Val Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            500                 505                 510         


Ala Gln Gly Gly Arg Ala Lys Ile Cys Gly Ile Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Leu Pro Ala Ala Ala Lys 
    530                 535                 540                 


Leu Asp Leu Ser Gly Trp Phe Thr Val Gly Ala Gly Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Met Ser His Ala Arg Pro Arg Tyr Leu Leu Leu Cys Leu 
                565                 570                 575     


Leu Ile Leu Thr Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  33
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  33

Ser Met Ser Tyr Thr Trp Thr Gly Ala Leu Ile Thr Pro Cys Ser Ala 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Thr Leu Leu Arg 
            20                  25                  30          


His His Asn Leu Val Tyr Ser Thr Ser Ser Arg Ser Ala Gly Leu Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp Asp His Tyr 
    50                  55                  60                  


Arg Glu Val Val Asp Glu Met Lys Arg Leu Ala Ser Lys Val Lys Ala 
65                  70                  75                  80  


Arg Leu Leu Pro Leu Glu Glu Ala Cys Gly Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Lys Tyr Gly Tyr Gly Ala Lys Glu Val Arg Ser Leu Asp 
            100                 105                 110         


Lys Lys Ala Leu Lys His Ile Glu Gly Val Trp Gln Asp Leu Leu Asp 
        115                 120                 125             


Asp Ser Asp Thr Pro Leu Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Ala Val Glu Pro Ser Lys Gly Gly Lys Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Arg Ala Leu Tyr 
                165                 170                 175     


Asp Val Ala Gln Lys Leu Pro Thr Ala Leu Met Gly Pro Ser Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Ala Gln Arg Val Asp Phe Leu Leu Lys Ala Trp 
        195                 200                 205             


Lys Ser Lys Lys Ile Pro Met Ala Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Ile Thr Glu His Asp Ile Met Thr Glu Glu Ser Ile Tyr 
225                 230                 235                 240 


Gln Ser Cys Asp Leu Gln Pro Glu Ala Arg Val Ala Ile Arg Ser Leu 
                245                 250                 255     


Thr Gln Arg Leu Tyr Cys Gly Gly Pro Met Tyr Asn Ser Lys Gly Gln 
            260                 265                 270         


Gln Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Phe Thr Thr Ser 
        275                 280                 285             


Met Gly Asn Thr Met Thr Cys Tyr Ile Lys Ala Leu Ala Ser Cys Arg 
    290                 295                 300                 


Ala Ala Lys Leu Arg Asp Cys Thr Leu Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Ala Ile Cys Glu Ser Gln Gly Thr His Glu Asp Glu Ala Ser Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Pro Pro Val Pro Ala Tyr Asp Leu Glu Leu Val Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala Arg Asp Ala Ser Gly Asn Arg Ile Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Gln Val Pro Leu Ala Lys Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Lys His Ser Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Tyr Ala 
                405                 410                 415     


Pro Thr Leu Trp Ala Arg Ile Val Leu Met Thr His Phe Phe Ser Val 
            420                 425                 430         


Leu Gln Ser Gln Glu Gln Leu Glu Lys Thr Leu Ala Phe Glu Met Tyr 
        435                 440                 445             


Gly Ser Val Tyr Ser Val Thr Pro Leu Asp Leu Pro Ala Ile Ile Gln 
    450                 455                 460                 


Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro Ser 
465                 470                 475                 480 


Glu Ile Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly Val Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            500                 505                 510         


Ala Gln Gly Gly Arg Ala Ala Ile Cys Gly Ile Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys Thr Lys Arg Lys Leu Thr Pro Leu Ala Asp Ala Asp Arg 
    530                 535                 540                 


Leu Asp Leu Ser Ser Trp Phe Thr Val Gly Ala Gly Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Met Ser Arg Ala Arg Pro Arg Asn Leu Leu Leu Cys Leu 
                565                 570                 575     


Leu Leu Leu Ser Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  34
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  34

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Ile Arg 
            20                  25                  30          


His His Asn Met Val Tyr Ser Thr Thr Ser Arg Ser Ala Ser Leu Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Phe Asp Gln His Tyr 
    50                  55                  60                  


Gln Asp Val Leu Lys Glu Ile Lys Leu Arg Ala Ser Thr Val Gln Ala 
65                  70                  75                  80  


Arg Leu Leu Ser Ile Glu Glu Ala Cys Asp Leu Thr Pro Ser His Ser 
                85                  90                  95      


Ala Arg Ser Lys Tyr Gly Tyr Gly Ala Gln Asp Val Arg Ser His Ala 
            100                 105                 110         


Ser Lys Ala Ile Asn His Ile Arg Ser Val Trp Glu Asp Leu Leu Glu 
        115                 120                 125             


Asp Ser Asp Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Asp Pro Ser Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Val Thr Arg Lys Leu Pro Gln Ala Val Met Gly Ser Ala Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Asn Gln Arg Val Glu Tyr Leu Leu Lys Met Trp 
        195                 200                 205             


Arg Ser Lys Lys Val Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Asn Asp Ile Tyr 
225                 230                 235                 240 


Gln Ser Cys Gln Leu Asp Pro Val Ala Arg Arg Ala Val Ser Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Val Gly Gly Pro Met Val Asn Ser Lys Gly Gln 
            260                 265                 270         


Ser Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Pro Thr Ser 
        275                 280                 285             


Met Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Gln Ala Ala Cys Arg 
    290                 295                 300                 


Ala Ala Asn Ile Lys Asp Cys Asp Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Cys Glu Ser Ala Gly Val Gln Glu Asp Thr Ala Ser Leu 
                325                 330                 335     


Arg Ala Phe Thr Asp Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Val Pro Gln Pro Thr Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Gly Asn Gly Lys Arg Tyr Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Cys Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Phe Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Val Leu Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Gln Ser Gln Glu Gln Leu Glu Lys Ala Leu Asp Phe Asp Ile Tyr 
        435                 440                 445             


Gly Val Thr Tyr Ser Val Ser Pro Leu Asp Leu Pro Ala Ile Ile Gln 
    450                 455                 460                 


Arg Leu His Gly Met Ala Ala Phe Ser Leu His Gly Tyr Ser Pro Thr 
465                 470                 475                 480 


Glu Leu Asn Arg Val Gly Ala Cys Leu Arg Lys Leu Gly Val Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            500                 505                 510         


Ala Gln Gly Gly Lys Ala Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Leu Val Ser Ala Ser Lys 
    530                 535                 540                 


Leu Asp Leu Ser Gly Trp Phe Val Ala Gly Tyr Asp Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser Gln Ala Arg Pro Arg Leu Leu Leu Leu Gly Leu 
                565                 570                 575     


Leu Leu Leu Thr Val Gly Val Gly Ile Phe Leu Val Pro Ala Arg 
            580                 585                 590     


<210>  35
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  35

Ser Met Ser Tyr Thr Trp Thr Gly Ala Leu Ile Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser Leu Ile Arg 
            20                  25                  30          


His His Asn Met Val Tyr Ser Thr Thr Ser Arg Ser Ala Gly Leu Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Val Asp Gln His Tyr 
    50                  55                  60                  


Gln Asp Val Leu Lys Glu Ile Lys Leu Arg Ala Ser Thr Val His Ala 
65                  70                  75                  80  


Arg Leu Leu Ser Thr Glu Glu Ala Cys Ser Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Arg Tyr Gly Tyr Gly Ala Arg Asp Val Arg Ser His Thr 
            100                 105                 110         


Ser Lys Ala Val Lys His Ile Asp Ser Val Trp Glu Asp Leu Leu Glu 
        115                 120                 125             


Asp Asn Ala Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Asp Pro Ser Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Ser Val Arg Val Cys Glu Lys Met Ala Leu Tyr 
                165                 170                 175     


Asp Val Thr Gln Lys Leu Pro Lys Thr Val Met Gly Ser Ala Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Ser Gln Arg Val Glu Tyr Leu Leu Lys Met Trp 
        195                 200                 205             


Arg Ser Lys Lys Thr Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Asp Ile Tyr 
225                 230                 235                 240 


Gln Ser Cys Gln Leu Asp Pro Thr Ala Arg Lys Ala Ile Ser Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Cys Gly Gly Pro Met Phe Asn Ser Lys Gly Glu 
            260                 265                 270         


Ser Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Leu Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Gln Ala Ala Cys Arg 
    290                 295                 300                 


Ala Ala Asn Ile Lys Asn Phe Asp Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Cys Glu Ser Ala Gly Val Gln Glu Asp Val Val Ala Leu 
                325                 330                 335     


Arg Ala Phe Thr Asp Ala Met Ile Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Ala Pro Gln Pro Thr Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Gly Thr Gly Gln Arg Tyr Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Cys Thr Thr Pro Leu Ala Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Tyr Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Val Leu Met Thr His Phe Phe Ser Ile 
            420                 425                 430         


Leu Gln Cys Gln Glu Gln Leu Glu Ala Ala Leu Asn Phe Asp Met Tyr 
        435                 440                 445             


Gly Val Thr Tyr Ser Val Thr Pro Leu Asp Leu Pro Ala Ile Ile Gln 
    450                 455                 460                 


Arg Leu His Gly Met Ala Ala Phe Ser Leu His Gly Tyr Ser Pro Thr 
465                 470                 475                 480 


Glu Leu Asn Arg Val Gly Ala Ser Leu Arg Lys Leu Gly Ala Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            500                 505                 510         


Ala Gln Gly Gly Lys Ala Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Lys Thr Lys Leu Lys Leu Thr Pro Leu Ala Ala Ala Ser Gln 
    530                 535                 540                 


Leu Asp Leu Ser Gly Trp Phe Val Ala Gly Tyr Asp Gly Gly Asp Ile 
545                 550                 555                 560 


Tyr His Ser Val Ser Arg Ala Arg Pro Arg Leu Leu Leu Leu Gly Leu 
                565                 570                 575     


Leu Leu Leu Thr Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


<210>  36
<211>  591
<212>  PRT
<213>  Hepatitis C virus

<400>  36

Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Ile Thr Pro Cys Ala Ala 
1               5                   10                  15      


Glu Glu Glu Lys Leu Pro Ile Ser Pro Leu Ser Asn Ala Leu Ile Arg 
            20                  25                  30          


His His Asn Leu Val Tyr Ser Thr Thr Ser Arg Ser Ala Ser Leu Arg 
        35                  40                  45              


Gln Lys Lys Val Thr Phe Asp Arg Val Gln Val Val Asp Gln His Tyr 
    50                  55                  60                  


Tyr Asp Val Leu Lys Glu Ile Lys Thr Lys Ala Ser Gly Val Ser Ala 
65                  70                  75                  80  


Lys Leu Leu Ser Val Glu Glu Ala Cys Ala Leu Thr Pro Pro His Ser 
                85                  90                  95      


Ala Arg Ser Lys Phe Gly Tyr Gly Ala Lys Glu Val Arg Gly Leu Ala 
            100                 105                 110         


Ser Lys Ala Val Asn His Ile Asn Ser Val Trp Glu Asp Leu Leu Glu 
        115                 120                 125             


Asp Asn Ser Thr Pro Ile Pro Thr Thr Ile Met Ala Lys Asn Glu Val 
    130                 135                 140                 


Phe Cys Val Asp Ala Gln Lys Gly Gly Arg Lys Pro Ala Arg Leu Ile 
145                 150                 155                 160 


Val Tyr Pro Asp Leu Gly Val Arg Val Cys Glu Lys Arg Ala Leu Tyr 
                165                 170                 175     


Asp Val Thr Gln Lys Leu Pro Ile Ala Val Met Gly Ala Ala Tyr Gly 
            180                 185                 190         


Phe Gln Tyr Ser Pro Lys Gln Arg Val Asp Tyr Leu Leu Lys Met Trp 
        195                 200                 205             


Arg Ser Lys Lys Thr Pro Met Gly Phe Ser Tyr Asp Thr Arg Cys Phe 
    210                 215                 220                 


Asp Ser Thr Val Thr Glu Arg Asp Ile Arg Thr Glu Glu Asp Ile Tyr 
225                 230                 235                 240 


Gln Cys Cys Gln Leu Asp Pro Val Ala Lys Lys Ala Ile Thr Ser Leu 
                245                 250                 255     


Thr Glu Arg Leu Tyr Cys Gly Gly Pro Met Tyr Asn Ser Arg Gly Gln 
            260                 265                 270         


Ser Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu Thr Thr Ser 
        275                 280                 285             


Leu Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Gln Ala Ala Cys Arg 
    290                 295                 300                 


Ala Ala Lys Leu Lys Asp Phe Asp Met Leu Val Cys Gly Asp Asp Leu 
305                 310                 315                 320 


Val Val Ile Ser Glu Ser Met Gly Val Ala Glu Asp Ala Ser Ala Leu 
                325                 330                 335     


Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly Asp 
            340                 345                 350         


Asp Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser Ser 
        355                 360                 365             


Asn Val Ser Val Ala His Asp Gly Ala Gly Gln Arg Tyr Tyr Tyr Leu 
    370                 375                 380                 


Thr Arg Asp Pro Leu Thr Pro Leu Ser Arg Ala Ala Trp Glu Thr Ala 
385                 390                 395                 400 


Arg His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile Ile Met Tyr Ala 
                405                 410                 415     


Pro Thr Ile Trp Val Arg Met Val Leu Met Thr His Phe Phe Ala Ile 
            420                 425                 430         


Leu Gln Ser Gln Glu Ile Leu His Lys Ala Leu Asp Phe Asp Met Tyr 
        435                 440                 445             


Gly Val Thr Tyr Ser Val Thr Pro Leu Asp Leu Pro Tyr Ile Ile Gln 
    450                 455                 460                 


Arg Leu His Gly Met Ala Ala Phe Ser Leu His Gly Tyr Ser Pro Gly 
465                 470                 475                 480 


Glu Leu Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly Ala Pro Pro 
                485                 490                 495     


Leu Arg Ala Trp Arg His Arg Ala Arg Ala Val Arg Ala Lys Leu Ile 
            500                 505                 510         


Ala Gln Gly Gly Lys His Ala Ile Cys Gly Lys Tyr Leu Phe Asn Trp 
        515                 520                 525             


Ala Val Arg Thr Lys Leu Lys Leu Thr Pro Leu Arg Gly Ala Ala Asn 
    530                 535                 540                 


Leu Asp Leu Ser Gly Trp Phe Val Ser Gly Gly Ser Gly Gly Asp Ile 
545                 550                 555                 560 


Phe His Ser Val Ser Arg Ala Arg Pro Arg Asn Leu Leu Leu Cys Leu 
                565                 570                 575     


Leu Leu Leu Thr Val Gly Val Gly Ile Phe Leu Leu Pro Ala Arg 
            580                 585                 590     


