               SEQUENCE LISTING

<110> INSTYTUT BIOCHEMII I BIOFIZYKI PAN

<120> Synthetic genes encoding peptide fragments of natural myelin proteins for induction of oral tolerance, DNA fragment comprising these genes, means of obtaining these peptides in a microbial (bacterial) system and their medical application

<130> 4277

<140> EP11176165.6
<141> 2011-08-01

<150> PLPL367507
<151> 2010-08-02

<160> 20

<170> BiSSAP 1.0

<210> 1
<211> 60
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..60
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 1
atggatcatg ctcgtcatgg ttttttacca cgtcatcgtg atactggtat tttagattca     60


<210> 2
<211> 20
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..20
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 2
Met Asp His Ala Arg His Gly Phe Leu Pro Arg His Arg Asp Thr Gly 
1               5                   10                   15    
Ile Leu Asp Ser 
            20

<210> 3
<211> 63
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..63
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 3
atggaagttg gatggtatcg ttcaccattt tcacgtgttg ttcatttata tcgtaatgga     60

aaa                                                                   63


<210> 4
<211> 21
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..21
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 4
Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                   15    
Tyr Arg Asn Gly Lys 
            20    

<210> 5
<211> 39
<212> DNA
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..39
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 5
ccaggatcac gtccacattt aattcgttta ttttcacgt                            39


<210> 6
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..13
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 6
Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser Arg 
1               5                   10            

<210> 7
<211> 39
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..39
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 7
cattcattag gaaaatggtt aggacatcca gataaattt                            39


<210> 8
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..13
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 8
His Ser Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe 
1               5                   10            

<210> 9
<211> 45
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..45
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 9
atgaatacat ggacaacatg tcaatcaatt gcttttccat caaaa                     45


<210> 10
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..14
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 10
Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
1               5                   10                

<210> 11
<211> 97
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..97
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 11
acgcgtcgac aaggagtatt tctatggatc atgctcgtca tggtttttta ccacgtcatc     60

gtgatactgg tattttagat tcataataac tgcagtt                              97


<210> 12
<211> 100
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..100
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 12
acgcgtcgac aaggagtatt tctatggaag ttggatggta tcgttcacca ttttcacgtg     60

ttgttcattt atatcgtaat ggaaaataat aactgcagtt                          100


<210> 13
<211> 79
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..79
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 13
acgcgtcgac aaggagtatt tctatgccag gatcacgtcc acatttaatt cgtttatttt     60

cacgttaata actgcagtt                                                  79


<210> 14
<211> 79
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..79
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 14
acgcgtcgac aaggagtatt tctatgcatt cattaggaaa atggttagga catccagata     60

aattttaata actgcagtt                                                  79


<210> 15
<211> 82
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..82
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 15
acgcgtcgac aaggagtatt tctatgaata catggacaac atgtcaatca attgcttttc     60

catcaaaata ataactgcag tt                                              82


<210> 16
<211> 140
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..140
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 16
gtcgcctaaa ggttgctata aagcgaaaaa taaactaatt aacaaattat ataaagcact     60

ttcaaaaaat agataacgct tgcattatga aaatgaaaac gttataatta tttttataaa    120

gaacgttaaa ttataaaacg                                                140


<210> 17
<211> 157
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..157
<223> /mol_type="DNA"
      /organism="Homo sapiens"

<400> 17
gcgattaatg tcgcctaaag gttgctataa agcgaaaaat aaactaatta acaaattata     60

taaagcactt tcaaaaaata gataacgctt gcattatgaa aatgaaaacg ttataattat    120

ttttataaag aacgttaaat tataaaacgc cgggatt                             157


<210> 18
<211> 304
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..304
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 18
Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                   15    
Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                   25                  30        
Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                   40                  45            
Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                   55                  60                
Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                   70                  75                  80
His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                   90                  95    
Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                  105                110        
Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                  120                125            
Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                  135                140                
Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                  150                155                  160
Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                  170                175    
Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                  185                190        
Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
        195                  200                205            
Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
    210                  215                220                
Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
225                  230                235                  240
Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 
                245                  250                255    
Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
            260                  265                270        
Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
        275                  280                285            
Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
    290                  295                300                

<210> 19
<211> 276
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..276
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 19
Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe Ala 
1               5                   10                   15    
Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe Cys 
            20                   25                  30        
Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr 
        35                   40                  45            
Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val Ile 
    50                   55                  60                
His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe Leu 
65                   70                  75                  80
Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala Val 
                85                   90                  95    
Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly Leu 
            100                  105                110        
Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly Gln 
        115                  120                125            
His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys Trp 
    130                  135                140                
Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr Val 
145                  150                155                  160
Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr 
                165                  170                175    
Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr 
            180                  185                190        
Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val 
        195                  200                205            
Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu 
    210                  215                220                
Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile 
225                  230                235                  240
Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe 
                245                  250                255    
Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg 
            260                  265                270        
Gly Thr Lys Phe 
        275    

<210> 20
<211> 247
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..247
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 20
Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                   15    
Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                   25                  30        
Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                   40                  45            
Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                   55                  60                
Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                   70                  75                  80
Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                   90                  95    
Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                  105                110        
Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                  120                125            
Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                  135                140                
Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                  150                155                  160
Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Val Phe Leu 
                165                  170                175    
Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                  185                190        
Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                  200                205            
Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                  215                220                
Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                  230                235                  240
Glu Glu Leu Arg Asn Pro Phe 
                245        

