                         SEQUENCE LISTING

<110>  Ablynx NV
 
<120>  SEQUENCES DIRECTED AGAINST HEPATOCYTE GROWTH FACTOR (HGF) AND 
       POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF CANCERS 
       AND/OR TUMORS

<130>  P12-002-PCT

<150>  US 61/589,569
<151>  2012-01-23

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                  25                  30          


Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                  40                  45              


Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                  55                  60                  


Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                  70                  75                  80  


Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                  90                  95      


Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                 105                 110         


Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                 120                 125             


Ile Ile His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly 
    130                 135                 140                 


Phe Asp Asp Glu Thr Thr Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr 
145                 150                 155                 160 


Arg Gly Thr Val Asn Thr Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp 
                165                 170                 175     


Asp Ser Gln Tyr Pro His Glu His Asp Met Thr Pro Glu Asn Phe Lys 
            180                 185                 190         


Cys Lys Asp Leu Arg Glu Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu 
        195                 200                 205             


Ser Pro Trp Cys Phe Thr Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys 
    210                 215                 220                 


Ser Gln Ile Pro Asn Cys Asp Met Ser His Gly Gln Asp Cys Tyr Arg 
225                 230                 235                 240 


Gly Asn Gly Lys Asn Tyr Met Gly Asn Leu Ser Gln Thr Arg Ser Gly 
                245                 250                 255     


Leu Thr Cys Ser Met Trp Asp Lys Asn Met Glu Asp Leu His Arg His 
            260                 265                 270         


Ile Phe Trp Glu Pro Asp Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg 
        275                 280                 285             


Asn Pro Asp Asp Asp Ala His Gly Pro Trp Cys Tyr Thr Gly Asn Pro 
    290                 295                 300                 


Leu Ile Pro Trp Asp Tyr Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr 
305                 310                 315                 320 


Thr Pro Thr Ile Val Asn Leu Asp His Pro Val Ile Ser Cys Ala Lys 
                325                 330                 335     


Thr Lys Gln Leu Arg Val Val Asn Gly Ile Pro Thr Arg Thr Asn Ile 
            340                 345                 350         


Gly Trp Met Val Ser Leu Arg Tyr Arg Asn Lys His Ile Cys Gly Gly 
        355                 360                 365             


Ser Leu Ile Lys Glu Ser Trp Val Leu Thr Ala Arg Gln Cys Phe Pro 
    370                 375                 380                 


Ser Arg Asp Leu Lys Asp Tyr Glu Ala Trp Leu Gly Ile His Asp Val 
385                 390                 395                 400 


His Gly Arg Gly Asp Glu Lys Cys Lys Gln Val Leu Asn Val Ser Gln 
                405                 410                 415     


Leu Val Tyr Gly Pro Glu Gly Ser Asp Leu Val Leu Met Lys Leu Ala 
            420                 425                 430         


Arg Pro Ala Val Leu Asp Asp Phe Val Ser Thr Ile Asp Leu Pro Asn 
        435                 440                 445             


Tyr Gly Cys Thr Ile Pro Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp 
    450                 455                 460                 


Gly Tyr Thr Gly Leu Ile Asn Tyr Asp Gly Leu Leu Arg Val Ala His 
465                 470                 475                 480 


Leu Tyr Ile Met Gly Asn Glu Lys Cys Ser Gln His His Arg Gly Lys 
                485                 490                 495     


Val Thr Leu Asn Glu Ser Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly 
            500                 505                 510         


Ser Gly Pro Cys Glu Gly Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln 
        515                 520                 525             


His Lys Met Arg Met Val Leu Gly Val Ile Val Pro Gly Arg Gly Cys 
    530                 535                 540                 


Ala Ile Pro Asn Arg Pro Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala 
545                 550                 555                 560 


Lys Trp Ile His Lys Ile Ile Leu Thr Tyr Lys Val Pro Gln Ser Asn 
                565                 570                 575     


Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr Thr Leu 
            580                 585                 590         


Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys Ala Asp 
        595                 600                 605             


Asn Thr Met Asn Asp Thr Asp Val Pro Leu Gly Lys Gly Arg Ser Tyr 
    610                 615                 620                 


Lys Gly Thr Val Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
625                 630                 635                 640 


Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
                645                 650                 655     


Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
            660                 665                 670         


His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
        675                 680                 685             


Ser Ile Thr Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile 
    690                 695                 700                 


Pro His Glu His Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu 
705                 710                 715                 720 


Gln Glu Asn Tyr Cys Arg Asn Pro 
                725             


<210>  2
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  2

Gln Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys 
1               5                   10                  15      


Thr Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys 
            20                  25                  30          


Val Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly 
        35                  40                  45              


Leu Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln 
    50                  55                  60                  


Cys Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu 
65                  70                  75                  80  


Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
                85                  90                  95      


Cys Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr 
            100                 105                 110         


Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu 
        115                 120                 125             


His Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 
    130                 135                 140                 


Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr 
145                 150                 155                 160 


Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 
                165                 170                 175     


Glu Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met 
            180                 185                 190         


Asp His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr 
        195                 200                 205             


Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 
    210                 215                 220                 


Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys 
225                 230                 235                 240 


Tyr Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr 
                245                 250                 255     


Cys Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr 
            260                 265                 270         


Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr 
        275                 280                 285             


Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 
    290                 295                 300                 


Glu His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 
305                 310                 315                 320 


Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr 
                325                 330                 335     


Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys 
            340                 345                 350         


Asp Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 
        355                 360                 365             


Met Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 
    370                 375                 380                 


Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp 
385                 390                 395                 400 


Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala 
                405                 410                 415     


His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 
            420                 425                 430         


Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 
        435                 440                 445             


Leu Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val 
    450                 455                 460                 


Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu 
465                 470                 475                 480 


Arg Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser 
                485                 490                 495     


Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp 
            500                 505                 510         


Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu 
        515                 520                 525             


Lys Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu 
    530                 535                 540                 


Gly Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp 
545                 550                 555                 560 


Asp Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro 
                565                 570                 575     


Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile 
            580                 585                 590         


Asn Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn 
        595                 600                 605             


Glu Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser 
    610                 615                 620                 


Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly 
625                 630                 635                 640 


Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val 
                645                 650                 655     


Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro 
            660                 665                 670         


Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile 
        675                 680                 685             


Ile Leu Thr Tyr Lys Val Pro Gln Ser 
    690                 695         


<210>  3
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant

<400>  3

Gln Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys 
1               5                   10                  15      


Thr Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys 
            20                  25                  30          


Val Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly 
        35                  40                  45              


Leu Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln 
    50                  55                  60                  


Cys Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu 
65                  70                  75                  80  


Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
                85                  90                  95      


Cys Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr 
            100                 105                 110         


Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu 
        115                 120                 125             


His Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 
    130                 135                 140                 


Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr 
145                 150                 155                 160 


Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 
                165                 170                 175     


Glu Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met 
            180                 185                 190         


Asp His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr 
        195                 200                 205             


Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 
    210                 215                 220                 


Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys 
225                 230                 235                 240 


Tyr Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr 
                245                 250                 255     


Cys Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr 
            260                 265                 270         


Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr 
        275                 280                 285             


Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 
    290                 295                 300                 


Glu His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 
305                 310                 315                 320 


Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr 
                325                 330                 335     


Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys 
            340                 345                 350         


Asp Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 
        355                 360                 365             


Met Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 
    370                 375                 380                 


Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp 
385                 390                 395                 400 


Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala 
                405                 410                 415     


His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 
            420                 425                 430         


Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 
        435                 440                 445             


Leu Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val 
    450                 455                 460                 


Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu 
465                 470                 475                 480 


Arg Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser 
                485                 490                 495     


Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp 
            500                 505                 510         


Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu 
        515                 520                 525             


Lys Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu 
    530                 535                 540                 


Gly Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp 
545                 550                 555                 560 


Asp Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro 
                565                 570                 575     


Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile 
            580                 585                 590         


Asn Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn 
        595                 600                 605             


Glu Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser 
    610                 615                 620                 


Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly 
625                 630                 635                 640 


Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val 
                645                 650                 655     


Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro 
            660                 665                 670         


Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile 
        675                 680                 685             


Ile Leu Thr Tyr Lys Val Pro Gln Ser 
    690                 695         


<210>  4
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  5
<211>  1152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimera

<400>  5

Glu Cys Lys Glu Ala Leu Ala Lys Ser Glu Met Asn Val Asn Met Lys 
1               5                   10                  15      


Tyr Gln Leu Pro Asn Phe Thr Ala Glu Thr Pro Ile Gln Asn Val Ile 
            20                  25                  30          


Leu His Glu His His Ile Phe Leu Gly Ala Thr Asn Tyr Ile Tyr Val 
        35                  40                  45              


Leu Asn Glu Glu Asp Leu Gln Lys Val Ala Glu Tyr Lys Thr Gly Pro 
    50                  55                  60                  


Val Leu Glu His Pro Asp Cys Phe Pro Cys Gln Asp Cys Ser Ser Lys 
65                  70                  75                  80  


Ala Asn Leu Ser Gly Gly Val Trp Lys Asp Asn Ile Asn Met Ala Leu 
                85                  90                  95      


Val Val Asp Thr Tyr Tyr Asp Asp Gln Leu Ile Ser Cys Gly Ser Val 
            100                 105                 110         


Asn Arg Gly Thr Cys Gln Arg His Val Phe Pro His Asn His Thr Ala 
        115                 120                 125             


Asp Ile Gln Ser Glu Val His Cys Ile Phe Ser Pro Gln Ile Glu Glu 
    130                 135                 140                 


Pro Ser Gln Cys Pro Asp Cys Val Val Ser Ala Leu Gly Ala Lys Val 
145                 150                 155                 160 


Leu Ser Ser Val Lys Asp Arg Phe Ile Asn Phe Phe Val Gly Asn Thr 
                165                 170                 175     


Ile Asn Ser Ser Tyr Phe Pro Asp His Pro Leu His Ser Ile Ser Val 
            180                 185                 190         


Arg Arg Leu Lys Glu Thr Lys Asp Gly Phe Met Phe Leu Thr Asp Gln 
        195                 200                 205             


Ser Tyr Ile Asp Val Leu Pro Glu Phe Arg Asp Ser Tyr Pro Ile Lys 
    210                 215                 220                 


Tyr Val His Ala Phe Glu Ser Asn Asn Phe Ile Tyr Phe Leu Thr Val 
225                 230                 235                 240 


Gln Arg Glu Thr Leu Asp Ala Gln Thr Phe His Thr Arg Ile Ile Arg 
                245                 250                 255     


Phe Cys Ser Ile Asn Ser Gly Leu His Ser Tyr Met Glu Met Pro Leu 
            260                 265                 270         


Glu Cys Ile Leu Thr Glu Lys Arg Lys Lys Arg Ser Thr Lys Lys Glu 
        275                 280                 285             


Val Phe Asn Ile Leu Gln Ala Ala Tyr Val Ser Lys Pro Gly Ala Gln 
    290                 295                 300                 


Leu Ala Arg Gln Ile Gly Ala Ser Leu Asn Asp Asp Ile Leu Phe Gly 
305                 310                 315                 320 


Val Phe Ala Gln Ser Lys Pro Asp Ser Ala Glu Pro Met Asp Arg Ser 
                325                 330                 335     


Ala Met Cys Ala Phe Pro Ile Lys Tyr Val Asn Asp Phe Phe Asn Lys 
            340                 345                 350         


Ile Val Asn Lys Asn Asn Val Arg Cys Leu Gln His Phe Tyr Gly Pro 
        355                 360                 365             


Asn His Glu His Cys Phe Asn Arg Thr Leu Leu Arg Asn Ser Ser Gly 
    370                 375                 380                 


Cys Glu Ala Arg Arg Asp Glu Tyr Arg Thr Glu Phe Thr Thr Ala Leu 
385                 390                 395                 400 


Gln Arg Val Asp Leu Phe Met Gly Gln Phe Ser Glu Val Leu Leu Thr 
                405                 410                 415     


Ser Ile Ser Thr Phe Ile Lys Gly Asp Leu Thr Ile Ala Asn Leu Gly 
            420                 425                 430         


Thr Ser Glu Gly Arg Phe Met Gln Val Val Val Ser Arg Ser Gly Pro 
        435                 440                 445             


Ser Thr Pro His Val Asn Phe Leu Leu Asp Ser His Pro Val Ser Pro 
    450                 455                 460                 


Glu Val Ile Val Glu His Thr Leu Asn Gln Asn Gly Tyr Thr Leu Val 
465                 470                 475                 480 


Ile Thr Gly Lys Lys Ile Thr Lys Ile Pro Leu Asn Gly Leu Gly Cys 
                485                 490                 495     


Arg His Phe Gln Ser Cys Ser Gln Cys Leu Ser Ala Pro Pro Phe Val 
            500                 505                 510         


Gln Cys Gly Trp Cys His Asp Lys Cys Val Arg Ser Glu Glu Cys Leu 
        515                 520                 525             


Ser Gly Thr Trp Thr Gln Gln Ile Cys Leu Pro Ala Ile Tyr Lys Val 
    530                 535                 540                 


Phe Pro Asn Ser Ala Pro Leu Glu Gly Gly Thr Arg Leu Thr Ile Cys 
545                 550                 555                 560 


Gly Trp Asp Phe Gly Phe Arg Arg Asn Asn Lys Phe Asp Leu Lys Lys 
                565                 570                 575     


Thr Arg Val Leu Leu Gly Asn Glu Ser Cys Thr Leu Thr Leu Ser Glu 
            580                 585                 590         


Ser Thr Met Asn Thr Leu Lys Cys Thr Val Gly Pro Ala Met Asn Lys 
        595                 600                 605             


His Phe Asn Met Ser Ile Ile Ile Ser Asn Gly His Gly Thr Thr Gln 
    610                 615                 620                 


Tyr Ser Thr Phe Ser Tyr Val Asp Pro Val Ile Thr Ser Ile Ser Pro 
625                 630                 635                 640 


Lys Tyr Gly Pro Met Ala Gly Gly Thr Leu Leu Thr Leu Thr Gly Asn 
                645                 650                 655     


Tyr Leu Asn Ser Gly Asn Ser Arg His Ile Ser Ile Gly Gly Lys Thr 
            660                 665                 670         


Cys Thr Leu Lys Ser Val Ser Asn Ser Ile Leu Glu Cys Tyr Thr Pro 
        675                 680                 685             


Ala Gln Thr Ile Ser Thr Glu Phe Ala Val Lys Leu Lys Ile Asp Leu 
    690                 695                 700                 


Ala Asn Arg Glu Thr Ser Ile Phe Ser Tyr Arg Glu Asp Pro Ile Val 
705                 710                 715                 720 


Tyr Glu Ile His Pro Thr Lys Ser Phe Ile Ser Gly Gly Ser Thr Ile 
                725                 730                 735     


Thr Gly Val Gly Lys Asn Leu Asn Ser Val Ser Val Pro Arg Met Val 
            740                 745                 750         


Ile Asn Val His Glu Ala Gly Arg Asn Phe Thr Val Ala Cys Gln His 
        755                 760                 765             


Arg Ser Asn Ser Glu Ile Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln 
    770                 775                 780                 


Leu Asn Leu Gln Leu Pro Leu Lys Thr Lys Ala Phe Phe Met Leu Asp 
785                 790                 795                 800 


Gly Ile Leu Ser Lys Tyr Phe Asp Leu Ile Tyr Val His Asn Pro Val 
                805                 810                 815     


Phe Lys Pro Phe Glu Lys Pro Val Met Ile Ser Met Gly Asn Glu Asn 
            820                 825                 830         


Val Leu Glu Ile Lys Gly Asn Asp Ile Asp Pro Glu Ala Val Lys Gly 
        835                 840                 845             


Glu Val Leu Lys Val Gly Asn Lys Ser Cys Glu Asn Ile His Leu His 
    850                 855                 860                 


Ser Glu Ala Val Leu Cys Thr Val Pro Asn Asp Leu Leu Lys Leu Asn 
865                 870                 875                 880 


Ser Glu Leu Asn Ile Glu Trp Lys Gln Ala Ile Ser Ser Thr Val Leu 
                885                 890                 895     


Gly Lys Val Ile Val Gln Pro Asp Gln Asn Phe Thr His Ile Glu Gly 
            900                 905                 910         


Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
        915                 920                 925             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    930                 935                 940                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
945                 950                 955                 960 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                965                 970                 975     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            980                 985                 990         


Glu Gln Tyr Asn Ser Thr Tyr Arg  Val Val Ser Val Leu  Thr Val Leu 
        995                 1000                 1005             


His Gln  Asp Trp Leu Asn Gly  Lys Glu Tyr Lys Cys  Lys Val Ser 
    1010                 1015                 1020             


Asn Lys  Ala Leu Pro Ala Pro  Ile Glu Lys Thr Ile  Ser Lys Ala 
    1025                 1030                 1035             


Lys Gly  Gln Pro Arg Glu Pro  Gln Val Tyr Thr Leu  Pro Pro Ser 
    1040                 1045                 1050             


Arg Asp  Glu Leu Thr Lys Asn  Gln Val Ser Leu Thr  Cys Leu Val 
    1055                 1060                 1065             


Lys Gly  Phe Tyr Pro Ser Asp  Ile Ala Val Glu Trp  Glu Ser Asn 
    1070                 1075                 1080             


Gly Gln  Pro Glu Asn Asn Tyr  Lys Thr Thr Pro Pro  Val Leu Asp 
    1085                 1090                 1095             


Ser Asp  Gly Ser Phe Phe Leu  Tyr Ser Lys Leu Thr  Val Asp Lys 
    1100                 1105                 1110             


Ser Arg  Trp Gln Gln Gly Asn  Val Phe Ser Cys Ser  Val Met His 
    1115                 1120                 1125             


Glu Ala  Leu His Asn His Tyr  Thr Gln Lys Ser Leu  Ser Leu Ser 
    1130                 1135                 1140             


Pro Gly  Lys His His His His  His His 
    1145                 1150         


<210>  6
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Val Gly Arg Ala Asp Leu Tyr Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  7
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Ser Ser Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Val Gly Arg Ala Asp Leu Tyr Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp His Tyr 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Leu Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ala Gly Cys Gly Ala Tyr Gly Leu Ile Pro Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  9
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Cys Ala Ile Ser Arg Ser Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Met Tyr Tyr Gly Ile Pro Asp Gln Asn Trp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Gly Ser Ser 
            20                  25                  30          


His Met Ala Trp Phe Arg Gln Val Pro Glu Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Cys Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Phe Trp Gly Ser Thr Ser Thr Arg Met Asp Asp Tyr 
            100                 105                 110         


Gln Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  11
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Cys Ala Ile Ser Arg Ser Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Met Tyr Tyr Gly Ile Pro Asp Gln Asn Trp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Cys Ala Ile Ser Arg Ser Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Met Tyr Tyr Gly Ile Pro Asp Gln Asn Trp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  13
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Pro Tyr 
            20                  25                  30          


Ala Ala Gly Trp Phe Arg His Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Thr Ala Ile Thr Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Tyr Arg Trp Gly Ile Thr His Glu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Cys Ala Ile Ser Arg Ser Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Met Tyr Tyr Gly Ile Pro Asp Gln Asn Trp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Asp Val Gly Arg Pro Asp Leu Tyr Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Gly Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Asn Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Leu Asp Pro Leu Gly Val Leu Ala Gly Thr Ser Gly Ile 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  17
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Cys Ala Ile Ser Arg Ser Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Met Tyr Tyr Gly Ile Pro Asp Gln Asn Trp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Asp Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ser Tyr Arg Trp Gly Ile Thr His Glu Tyr Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Cys Ala Ile Ser Arg Ser Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Met Tyr Tyr Gly Ile Pro Asp Gln Asn Trp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Leu Gly Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Asn Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Glu Trp Gly Asp Tyr Pro Gly Gln Val Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Cys Ala Ile Ser Arg Ser Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Met Tyr Tyr Gly Ile Pro Asp Gln Asn Trp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  22
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  22

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Asn Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Ser Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Thr Gln Pro Asn Phe Gly Trp Gln Leu Leu Leu Leu Gln Thr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  23
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Pro Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Arg Thr Trp Ser Gly Gly Val Ala Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Glu Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Ser Pro Gly Arg Thr Tyr Ser Pro Arg Glu Glu Arg Ala 
            100                 105                 110         


Tyr Ala Arg Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  24
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Asp Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Asn Thr Gly Gly Pro Ile Thr Ser Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Asn Cys 
                85                  90                  95      


Ala Ala Arg Leu Pro Thr Lys Met Ser Pro Arg Asp Tyr Ser Ser Tyr 
            100                 105                 110         


Ala Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  25
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn Leu Asn 
            20                  25                  30          


Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Val Thr Gly Glu Gly Arg Thr Asn Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Ala Phe Trp Ala Tyr Asp Asp Ala Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  26
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Cys Ala Ile Ser Arg Ser Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Lys Asp Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Met Tyr Tyr Gly Ile Pro Asp Gln Asn Trp Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  27
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Asp Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Val Asn Trp Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Val Gly Arg Ala Asp Leu Tyr Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  28
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30  


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp 
            20                  25                  30  


<210>  30
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Gly 
            20                  25                  30  


<210>  31
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30  


<210>  32
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30  


<210>  33
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Asp Ser 
            20                  25                  30  


<210>  34
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Leu Gly 
            20                  25                  30  


<210>  35
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Leu Ser 
            20                  25                  30  


<210>  36
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  36

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30  


<210>  37
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser 
            20                  25                  30  


<210>  38
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser 
            20                  25                  30  


<210>  39
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Asn 
            20                  25                  30  


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  40

Ser Tyr Ala Met Gly 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  41

His Tyr Thr Ile Gly 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  42

Ser Ser His Met Ala 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  43

Ser Tyr Ala Met Gly 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  44

Asp Tyr Ala Met Ser 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  45

Ser Tyr Ala Met Gly 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  46

Ile Asn Ala Met Gly 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  47

Asn Tyr Ala Met Gly 
1               5   


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  48

Ser Tyr Ala Met Gly 
1               5   


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  49

Pro Tyr Thr Met Gly 
1               5   


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  50

Asp Tyr Thr Met Gly 
1               5   


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  51

Leu Asn Pro Met Gly 
1               5   


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  52

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  53
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  53

Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Gly Val Ser 
1               5                   10                  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  54

Trp Phe Arg Gln Val Pro Glu Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  55

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  56

Trp Gly Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  57

Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val Ala 
1               5                   10                  


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  58

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  59
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  59

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val Cys 
1               5                   10                  


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  60

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Asn Val Ala 
1               5                   10                  


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  61

Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  62
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  62

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  63
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  63

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  64
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  64

Gly Ile Ser Trp Ser Gly Ser Ser Ser Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  65

Cys Ile Ser Ser Leu Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  66

Ala Ile Ser Arg Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  67

Ala Ile Asn Trp Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  68

Ala Ile Ser Trp Asn Gly Gly Ser Thr Tyr Tyr Ala Glu Ser Met Lys 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  69

Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  70

Val Ile Asn Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  71

Ala Ile Ser Arg Ser Gly Ser Ile Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  72

Ala Ile Ser Ser Ser Gly Gly Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  73

Ala Arg Thr Trp Ser Gly Gly Val Ala Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  74

Arg Ile Asn Thr Gly Gly Pro Ile Thr Ser Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  75

Thr Val Thr Gly Glu Gly Arg Thr Asn Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  76
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  76

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  77
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  77

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val 
            20                  25                  30          


<210>  78
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  78

Arg Cys Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  79
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  79

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  80
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  80

Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  81
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  81

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Ala 
            20                  25                  30          


<210>  82
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  82

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
            20                  25                  30          


<210>  83
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  83

Arg Phe Thr Ile Ala Lys Asp Asn Ala Ala Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  84
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  84

Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Gly 
            20                  25                  30          


<210>  85
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  85

Arg Phe Thr Ile Ser Ser Asp Asn Ala Glu Asn Met Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  86
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  86

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Asn Cys Ala Ala 
            20                  25                  30          


<210>  87
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  87

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
            20                  25                  30          


<210>  88
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  88

Asp Pro Val Gly Arg Ala Asp Leu Tyr Glu Tyr Asp Tyr 
1               5                   10              


<210>  89
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  89

Ala Gly Cys Gly Ala Tyr Gly Leu Ile Pro Tyr Asp Tyr 
1               5                   10              


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  90

Ala Arg Phe Trp Gly Ser Thr Ser Thr Arg Met Asp Asp Tyr Gln Tyr 
1               5                   10                  15      


<210>  91
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  91

Gly Asp Val Gly Arg Pro Asp Leu Tyr Glu Tyr Asp Tyr 
1               5                   10              


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  92

Ala Leu Asp Pro Leu Gly Val Leu Ala Gly Thr Ser Gly Ile Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  93

Ser Tyr Arg Trp Gly Ile Thr His Glu Tyr Glu Tyr 
1               5                   10          


<210>  94
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  94

Asp Glu Trp Gly Asp Tyr Pro Gly Gln Val Tyr Asp Tyr 
1               5                   10              


<210>  95
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  95

Asp Pro Met Tyr Tyr Gly Ile Pro Asp Gln Asn Trp Asp Tyr 
1               5                   10                  


<210>  96
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  96

Thr Gln Pro Asn Phe Gly Trp Gln Leu Leu Leu Leu Gln Thr Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  97

Lys Ser Pro Gly Arg Thr Tyr Ser Pro Arg Glu Glu Arg Ala Tyr Ala 
1               5                   10                  15      


Arg 
    


<210>  98
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  98

Arg Leu Pro Thr Lys Met Ser Pro Arg Asp Tyr Ser Ser Tyr Ala Tyr 
1               5                   10                  15      


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  99

Ala Phe Trp Ala Tyr Asp Asp Ala Tyr 
1               5                   


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  100

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  101

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  102

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  103

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  104

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  105

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  106

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  107

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  108

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  109

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  110

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  111

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  112
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Ser Ser Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Val Gly Arg Ala Asp Leu Tyr Glu Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
145                 150                 155                 160 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly 
                245                 250                 255     


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            260                 265                 270         


Ala Ala His His His His His His 
        275                 280 


<210>  113
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Asp Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu His Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Ala Ser Tyr Arg Trp Gly Ile Thr His Glu Tyr Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp 
            180                 185                 190         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr 
        195                 200                 205             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp 
                245                 250                 255     


Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala 
            260                 265                 270         


Ala His His His His His His 
        275                 


<210>  114
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  115
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
        115                 120                 125             


Asn Gly Ala Ala His His His His His His 
    130                 135             


<210>  116
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tag

<400>  116

Gly Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
1               5                   10                  15      


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala His His His His 
            20                  25                  30          


His His 
        


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  117

Gly Gly Gly Gly Ser 
1               5   


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  118

Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  119

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  120

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  121

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  122
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  122

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  123
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  123

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  124
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  124

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  125
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  125

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  126
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic linker

<400>  126

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  127
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  127

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala 
        


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  128

Ser Phe Gly Met Ser 
1               5   


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  129

Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISVD derived sequence

<400>  130

Gly Gly Ser Leu Ser Arg 
1               5       


