﻿               SEQUENCE LISTING

<110> Canvax Biotech S.L.

<120> HETEROLOGOUS VIRAL-GPCR-DERIVED SEQUENCES AND USES THEREOF

<130> PCT-05143

<160> 9

<170> BiSSAP 1.0

<210> 1
<211> 105
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..105
<223> /mol_type="DNA"
      /note="Heterologous viral-GPCR sequence derived (VGS)"
      /organism="Artificial Sequence"

<400> 1
ctgagcacaa tggccccagg ctccaccgtg ggaacactcg atgccaacat gaccagcgtg     60

aatgccacag aggacgcctg caccaagagc tacagcgcct tcctc                    105


<210> 2
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..36
<223> /mol_type="DNA"
      /note="Heterologous viral-GPCR sequence derived (VGS shorter sequ
      ence)"
      /organism="Artificial Sequence"

<400> 2
ctgagcacaa tggccccagg ctccaccgtg ggaaca                               36


<210> 3
<211> 1205
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1205
<223> /mol_type="DNA"
      /note="Human elongation factor 1 alpha promoter"
      /organism="Artificial Sequence"

<400> 3
ttgctgactt gcgtgaggct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt      60

ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg     120

ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga     180

accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag     240

aacacaggta agtgccgtgt gtggttcccg cgggcctggc ctctttacgg gttatggccc     300

ttgcgtgcct tgaattactt ccacgcccct ggctgcagta cgtgattctt gatcccgagc     360

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     420

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     480

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     540

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     600

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt     660

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     720

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     780

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     840

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     900

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     960

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg    1020

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc    1080

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt    1140

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgct    1200

agctt                                                                1205


<210> 4
<211> 790
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..790
<223> /mol_type="DNA"
      /note="Human phosphoglycerate kinase promoter"
      /organism="Artificial Sequence"

<400> 4
agatctcccg atcccctatg gtgcactctc agtacaatct gctctgatgc cgcatagtta      60

agccagtatc tgctccctgc ttgtgtgttg gaggtcgctg agtagtgcgc gagcaaaatt     120

taagctacaa caaggcaagg cttgaccgac aattgcatga agaatctgct tagggttagg     180

cgttttgcgc tgcttcgcga tgtacgggcc agatatacgc gttgacattg attattgact     240

agagtcatac ctgtttggat ccaaccgggt aggggaggcg cttttcccaa ggcagtctgg     300

agcatgcgct ttagcagccc cgctgggcac ttggcgctac acaagtggcc tctggcctcg     360

cacacattcc acatccaccg gtaggcgcca accggctccg ttctttggtg gccccttcgc     420

gccaccttct actcctcccc tagtcaggaa gttccccccc gccccgcagc tcgcgtcgtg     480

caggacgtga caaatggaag tagcacgtct cactagtctc gtgcagatgg acagcaccgc     540

tgagcaatgg aagcgggtag gcctttgggg cagcggccaa tagcagcttt gctccttcgc     600

tttctgggct cagaggctgg gaaggggtgg gtccgggggc gggctcaggg gcgggctcag     660

gggcggggcg ggcgcccgaa ggtcctccgg aggcccggca ttctgcacgc ttcaaaagcg     720

cacgtctgcc gcgctgtcct cctcttcctc atctcgggct cgagtaggaa ttatctgcgg     780

cctagctagc                                                            790


<210> 5
<211> 428
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..428
<223> /mol_type="DNA"
      /note="Rous sarcoma virus promoter"
      /organism="Artificial Sequence"

<400> 5
cgacctcatg gctgcgcccc gacacccgcc aacacccgct gacgcctgac gggcttgtct      60

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     120

gttttcaccg tcatcaccga aacgcgcgag gcagccggat cataatcagc cataccacat     180

ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata     240

aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa     300

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt     360

tgtccaaact catcaatgta tcttatcatg tctggatccg gccttgccgg cctcgagcgg     420

ccgctagc                                                              428


<210> 6
<211> 479
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..479
<223> /mol_type="DNA"
      /note="Promoter MoMLV-5´LTR"
      /organism="Artificial Sequence"

<400> 6
agtctccaga aaaagggggg aatgaaagac cccacctgta ggtttggcaa gctagcttaa      60

gtaacgccat tttgcaaggc atggaaaaat acataactga gaatagagaa gttcagatca     120

aggtcaggaa cagatggaac agctgaatat gggccaaaca ggatatctgt ggtaagcagt     180

tcctgccccg gctcagggcc aagaacagat ggaacagctg aatatgggcc aaacaggata     240

tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg     300

tccagccctc agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg     360

aaatgaccct gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc     420

gcttctgctc cccgagctca ataaaagagc ccacaacccc tcactcgggg cgccagtcc      479


<210> 7
<211> 5348
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..5348
<223> /mol_type="DNA"
      /note="Vector with the structure PMo-MLV-5´LTR-SP-cmyc-VGS-MCS-po
      lyA"
      /organism="Artificial Sequence"

<400> 7
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgtg atatcgaatt cagtctccag aaaaaggggg      240

gaatgaaaga ccccacctgt aggtttggca agctagctta agtaacgcca ttttgcaagg      300

catggaaaaa tacataactg agaatagaga agttcagatc aaggtcagga acagatggaa      360

cagctgaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc ggctcagggc      420

caagaacaga tggaacagct gaatatgggc caaacaggat atctgtggta agcagttcct      480

gccccggctc agggccaaga acagatggtc cccagatgcg gtccagccct cagcagtttc      540

tagagaacca tcagatgttt ccagggtgcc ccaaggacct gaaatgaccc tgtgccttat      600

ttgaactaac caatcagttc gcttctcgct tctgttcgcg cgcttctgct ccccgagctc      660

aataaaagag cccacaaccc ctcactcggg gcgccagtcc aagcttggta ccgagctcgg      720

atcgatcatg gagacagaca cactcctgct atgggtactg ctgctctggg ttccaggttc      780

caccggtgac gaacaaaaac tcatctcaga agaggatctg gggccatcgc gactgagcac      840

aatggcccca ggctccaccg tgggaacact cgagggatcc gcggccgctc tagagggccc      900

tattctatag tgtcacctaa atgctagagc tcgctgatca gcctcgactg tgccttctag      960

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     1020

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     1080

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     1140

caggcatgct ggggatgcgg tgggctctat ggcttctgag gcggaaagaa ccagctgggg     1200

ctctaggggg tatccccacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt     1260

tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt     1320

cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc     1380

tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga     1440

tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc     1500

cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt     1560

ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct     1620

gatttaacaa aaatttaacg cgaattaatt ctgtggaatg tgtgtcagtt agggtgtgga     1680

aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca     1740

accaggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc     1800

aattagtcag caaccatagt cccgccccta actccgccca tcccgcccct aactccgccc     1860

agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc agaggccgag     1920

gccgcctctg cctctgagct attccagaag tagtgaggag gcttttttgg aggcctaggc     1980

ttttgcaaaa agctcccggg agcttgtata tccattttcg gatctgatca agagacagga     2040

tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg caggttctcc ggccgcttgg     2100

gtggagaggc tattcggcta tgactgggca caacagacaa tcggctgctc tgatgccgcc     2160

gtgttccggc tgtcagcgca ggggcgcccg gttctttttg tcaagaccga cctgtccggt     2220

gccctgaatg aactgcagga cgaggcagcg cggctatcgt ggctggccac gacgggcgtt     2280

ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa gggactggct gctattgggc     2340

gaagtgccgg ggcaggatct cctgtcatct caccttgctc ctgccgagaa agtatccatc     2400

atggctgatg caatgcggcg gctgcatacg cttgatccgg ctacctgccc attcgaccac     2460

caagcgaaac atcgcatcga gcgagcacgt actcggatgg aagccggtct tgtcgatcag     2520

gatgatctgg acgaagagca tcaggggctc gcgccagccg aactgttcgc caggctcaag     2580

gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat     2640

atcatggtgg aaaatggccg cttttctgga ttcatcgact gtggccggct gggtgtggcg     2700

gaccgctatc aggacatagc gttggctacc cgtgatattg ctgaagagct tggcggcgaa     2760

tgggctgacc gcttcctcgt gctttacggt atcgccgctc ccgattcgca gcgcatcgcc     2820

ttctatcgcc ttcttgacga gttcttctga gcgggactct ggggttcgaa atgaccgacc     2880

aagcgacgcc caacctgcca tcacgagatt tcgattccac cgccgccttc tatgaaaggt     2940

tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc ggggatctca     3000

tgctggagtt cttcgcccac cccaacttgt ttattgcagc ttataatggt tacaaataaa     3060

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt     3120

tgtccaaact catcaatgta tcttatcatg tctgtatacc gtcgacctct agctagagct     3180

tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac     3240

acaacatacg agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac     3300

tcacattaat tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc     3360

tgcattaatg aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg     3420

cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc     3480

actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt     3540

gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc     3600

ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa     3660

acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc     3720

ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg     3780

cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc     3840

tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc     3900

gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca     3960

ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact     4020

acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg     4080

gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc ggtttttttg     4140

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     4200

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     4260

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct     4320

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta     4380

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa     4440

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac     4500

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa     4560

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag     4620

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg     4680

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag     4740

ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg     4800

tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc     4860

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat     4920

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata     4980

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa     5040

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca     5100

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc     5160

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc     5220

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg     5280

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac     5340

ctgacgtc                                                              5348


<210> 8
<211> 35
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..35
<223> /mol_type="protein"
      /note="Heterologous viral-GPCR sequence derived (VGS)"
      /organism="Artificial Sequence"

<400> 8
Leu Ser Thr Met Ala Pro Gly Ser Thr Val Gly Thr Leu Asp Ala Asn 
1               5                   10                   15    
Met Thr Ser Val Asn Ala Thr Glu Asp Ala Cys Thr Lys Ser Tyr Ser 
            20                   25                  30        
Ala Phe Leu 
        35

<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> SOURCE
<222> 1..12
<223> /mol_type="protein"
      /note="Heterologous viral-GPCR sequence derived (VGS shorter sequ
      ence)"
      /organism="Artificial Sequence"

<400> 9
Leu Ser Thr Met Ala Pro Gly Ser Thr Val Gly Thr 
1               5                   10        

