                         SEQUENCE LISTING

<110>  Pieris AG
 
<120>  Muteins of a1m lipocalin and method of production therefor

<130>  PIE14416PCT

<150>  US 61/592,843
<151>  2012-01-31

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  183
<212>  PRT
<213>  human


<220>
<221>  misc_feature
<222>  (1)..(183)
<223>  wild-type human a1m sequence

<400>  1

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Ser Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn 
                85                  90                  95      


Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ile Leu Ile Pro Arg 
            180             


<210>  2
<211>  78
<212>  DNA
<213>  artificial

<220>
<223>  Primer for construction of a1m library


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  n = g, a, t, or c

<400>  2
ctggcaattg gtagcaccnn nccgnnnnnn aagaaaatca tggatcgtat gaccgttnnn       60

accctggttc tgggtgaa                                                     78


<210>  3
<211>  84
<212>  DNA
<213>  artificial

<220>
<223>  Primer for construction of a1m library


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  n = g, a, t, or c

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  n = g, a, t, or c

<400>  3
accgaagcag aaatcagcnn naccnnnacc cgttggcgta aaggtgtttg tnnngaannn       60

agcnnngcct acgaaagacc gata                                              84


<210>  4
<211>  116
<212>  DNA
<213>  artificial

<220>
<223>  Primer for construction of a1m library


<220>
<221>  misc_features
<222>  (19)..(19)
<223>  n =t, a, g or c

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_features
<222>  (20)..(20)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (21)..(21)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (40)..(40)
<223>  n =t, a, g or c

<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  n is a, c, g, or t

<220>
<221>  misc_features
<222>  (41)..(41)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (42)..(42)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (46)..(46)
<223>  n =t, a, g or c

<220>
<221>  misc_feature
<222>  (46)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_features
<222>  (47)..(47)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (48)..(48)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (84)..(84)
<223>  n =t, a, g or c

<220>
<221>  misc_feature
<222>  (84)..(86)
<223>  n is a, c, g, or t

<220>
<221>  misc_features
<222>  (85)..(85)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (86)..(86)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (90)..(90)
<223>  n =t, a, g or c

<220>
<221>  misc_feature
<222>  (90)..(92)
<223>  n is a, c, g, or t

<220>
<221>  misc_features
<222>  (91)..(91)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (92)..(92)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (96)..(96)
<223>  n =t, a, g or c

<220>
<221>  misc_feature
<222>  (96)..(98)
<223>  n is a, c, g, or t

<220>
<221>  misc_features
<222>  (97)..(97)
<223>  n =t, a, g or c

<220>
<221>  misc_features
<222>  (98)..(98)
<223>  n =t, a, g or c

<400>  4
accgacggta aattcctgnn ncataaaagc aaacataacn nnaccnnnga aagctatgtc       60

gtgcacaccg tcagcatggt ccgnnnattn nngcannnct gtatggtcgt gcacct          116


<210>  5
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Primer for construction of a1m library


<220>
<221>  misc_features
<222>  (19)..(19)
<223>  n =t, a, c or g

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  n is a, c, g, or t

<220>
<221>  misc_features
<222>  (20)..(20)
<223>  n =t, a, c or g

<220>
<221>  misc_features
<222>  (21)..(21)
<223>  n =t, a, c or g

<220>
<221>  misc_features
<222>  (25)..(25)
<223>  n =t, a, c or g

<220>
<221>  misc_feature
<222>  (25)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_features
<222>  (26)..(26)
<223>  n =t, a, c or g

<220>
<221>  misc_features
<222>  (27)..(27)
<223>  n =t, a, c or g

<400>  5
gagtacgcca tcttcctgnn naaannnttc agc                                    33


<210>  6
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Primer for construction of a1m library

<400>  6
tgggaccaag acccacttcc acgatggctt cgtctttagt cg                          42


<210>  7
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Primer for construction of a1m library

<400>  7
cggatgcttt tctggctatg gctgccattt aaggac                                 36


<210>  8
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Primer for construction of a1m library

<400>  8
ttcgatacag cacgtgtggt tgatactact catgcggtag aaggac                      46


<210>  9
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Primer for construction of a1m library

<400>  9
gacataccag cacgtggagt cgacgcactt tgggacgacg tccta                       45


<210>  10
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Primer for construction of a1m library

<400>  10
tatctcccag atctatggga aatggtataa tctggcaatt ggtagcacc                   49


<210>  11
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Primer for construction of a1m library

<400>  11
ctttgggacg acgtcctaaa agcacaacaa cgggtcccac aaccgtaggg                  50


<210>  12
<211>  183
<212>  PRT
<213>  Artificial

<220>
<223>  a1m mutein D1A10

<400>  12

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Gln Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Lys Pro Val Lys Lys Lys Ile Met Asp Arg Met Thr Val Ala Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Tyr 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Lys Glu Phe Ser Glu Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Gly His Lys Ser Lys His Asn 
                85                  90                  95      


Val Thr Trp Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Tyr Lys His Phe Ser Arg Gln His Gly Pro Ile Ile Met 
        115                 120                 125             


Ala Ala Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ile Leu Ile Pro Arg 
            180             


<210>  13
<211>  183
<212>  PRT
<213>  Artificial

<220>
<223>  a1m mutein D1A11

<400>  13

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Gln Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Ile Pro Glu Arg Lys Lys Ile Met Asp Arg Met Thr Val Gln Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Ala Thr Ala 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Pro Ser Asp Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys His Asn 
                85                  90                  95      


Tyr Thr His Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Lys Lys Lys Phe Ser Arg Gln His Gly Pro Trp Ile Asn 
        115                 120                 125             


Ala Trp Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ile Leu Ile Pro Arg 
            180             


<210>  14
<211>  183
<212>  PRT
<213>  Artificial

<220>
<223>  a1m mutein D1B1

<400>  14

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Gln Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Gln Pro Arg Leu Lys Lys Ile Met Asp Arg Met Thr Val His Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Gly Thr Pro 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Lys Glu Phe Ser Lys Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Lys His Lys Ser Lys His Asn 
                85                  90                  95      


His Thr Lys Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Arg Lys Ile Phe Ser Arg Gln His Gly Pro Ser Ile Ile 
        115                 120                 125             


Ala Tyr Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ile Leu Ile Pro Arg 
            180             


<210>  15
<211>  183
<212>  PRT
<213>  Artificial

<220>
<223>  a1m mutein D1E1

<400>  15

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Gln Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr His Pro Lys Gln Lys Lys Ile Met Asp Arg Met Thr Val Ile Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Val Thr Glu 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Trp Glu Phe Ser Arg Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Ile His Lys Ser Lys His Asn 
                85                  90                  95      


Asn Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Met Phe Ser Arg Gln His Gly Pro Trp Ile Met 
        115                 120                 125             


Ala Glu Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ile Leu Ile Pro Arg 
            180             


<210>  16
<211>  183
<212>  PRT
<213>  Artificial

<220>
<223>  a1m mutein D1H3

<400>  16

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Gln Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Ile Pro Thr Lys Lys Lys Ile Met Asp Arg Met Thr Val Asp Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Gly 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Ala Glu Trp Gly Tyr Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Asn His Lys Ser Lys His Asn 
                85                  90                  95      


Tyr Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Phe Lys Met Phe Ser Arg Gln His Gly Pro Trp Ile Val 
        115                 120                 125             


Ala Gln Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ile Leu Ile Pro Arg 
            180             


<210>  17
<211>  183
<212>  PRT
<213>  Artificial

<220>
<223>  a1m mutein D1H3

<400>  17

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Gln Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Phe Pro Trp His Lys Lys Ile Met Asp Arg Met Thr Val Tyr Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Asn Thr Glu 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Leu Glu His Ser Arg Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Lys His Lys Ser Lys His Asn 
                85                  90                  95      


Glu Thr Trp Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Ser Lys Asp Phe Ser Arg Gln His Gly Pro Pro Ile Glu 
        115                 120                 125             


Ala Met Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ile Leu Ile Pro Arg 
            180             


<210>  18
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  a1m mutein C1A1

<400>  18

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Gln Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Ser Pro His Lys Lys Ile Met Asp Arg Met Thr Val Asp Thr Leu 
        35                  40                  45              


Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Ala Thr Ile Thr 
    50                  55                  60                  


Arg Trp Arg Lys Gly Val Cys Glu Glu His Ser Tyr Ala Tyr Glu Lys 
65                  70                  75                  80  


Thr Asp Thr Asp Gly Lys Phe Leu Trp His Lys Ser Lys His Asn Glu 
                85                  90                  95      


Thr Val Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile 
            100                 105                 110         


Phe Leu Ile Lys Trp Phe Ser Arg Gln His Gly Pro His Ile Glu Ala 
        115                 120                 125             


Trp Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp 
    130                 135                 140                 


Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe 
145                 150                 155                 160 


Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu 
                165                 170                 175     


Pro Ile Leu Ile Pro Arg 
            180         


<210>  19
<211>  182
<212>  PRT
<213>  Artificial

<220>
<223>  a1m mutein C1D1

<400>  19

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Gln Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Pro Phe Ser Lys Lys Ile Met Asp Arg Met Thr Val Asp Thr Leu 
        35                  40                  45              


Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Val Thr Phe Thr 
    50                  55                  60                  


Arg Trp Arg Lys Gly Val Cys Tyr Glu Lys Ser Glu Ala Tyr Glu Lys 
65                  70                  75                  80  


Thr Asp Thr Asp Gly Lys Phe Leu Leu His Lys Ser Lys His Asn Gln 
                85                  90                  95      


Thr Ile Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile 
            100                 105                 110         


Phe Leu Ile Lys Glu Phe Ser Arg Gln His Gly Pro Asn Ile Val Ala 
        115                 120                 125             


Phe Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln Asp 
    130                 135                 140                 


Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile Phe 
145                 150                 155                 160 


Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro Glu 
                165                 170                 175     


Pro Ile Leu Ile Pro Arg 
            180         


<210>  20
<211>  4978
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid pNGAL 108

<400>  20
ccatcgaatg gccagatgat taattcctaa tttttgttga cactctatca ttgatagagt       60

tattttacca ctccctatca gtgatagaga aaagtgaaat gaatagttcg acaaaaatct      120

agataacgag ggcaaaaaat gaaaaagaca gctatcgcga ttgcagtggc tctggctggc      180

ttcgctaccg tagcgcaggc cggccctgtg ccaacgccgc ccgacaatat ccaagtgcag      240

gaaaacttca atatctccca gatctatggg aagtggtaca acctggccat cggttccacc      300

agcccctggc tgaagaagat catggacagg atgacagtga gcacgctggt gctgggagag      360

ggcgctacag aggcggagat cagcatgacc agcactcgtt ggcggaaagg tgtctgtgag      420

gagacgtctg gagcttatga gaaaacagat actgatggga agtttctcta tcacaaatcc      480

aaatggaaca taaccatgga gtcctatgtg gtccacacca actatgatga gtatgccatt      540

ttcctgacca agaaattcag ccgccatcat ggacccacca ttactgccaa gctctacggg      600

cgggcgccgc agctgaggga aactctcctg caggacttca gagtggttgc ccagggtgtt      660

ggcatccctg aggactccat cttcaccatg gctgaccgag gtgaatgtgt ccctggggag      720

caggaaccag agcccatctt aatcccgaga agcgcttggc gtcacccgca gttcggtggg      780

gcctagactg ttgaaagttg tttagcaaaa ccccatacag aaaattcatt tactaacgtc      840

tggaaagacg acaaaacttt agatcgttac gctaactatg agggctgtct gtggaatgct      900

acaggcgttg tagtttgtac tggtgacgaa actcagtgtt acggtacatg ggttcctatt      960

gggcttgcta tccctgaaaa tgagggtggt ggctctgagg gtggcggttc tgagggtggc     1020

ggttctgagg gtggcggtac taaacctcct gagtacggtg atacacctat tccgggctat     1080

acttatatca accctctcga cggcacttat ccgcctggta ctgagcaaaa ccccgctaat     1140

cctaatcctt ctcttgagga gtctcagcct cttaatactt tcatgtttca gaataatagg     1200

ttccgaaata ggcagggggc attaactgtt tatacgggca ctgttactca aggcactgac     1260

cccgttaaaa cttattacca gtacactcct gtatcatcaa aagccatgta tgacgcttac     1320

tggaacggta aattcagaga ctgcgctttc cattctggct ttaatgagga tccattcgtt     1380

tgtgaatatc aaggccaatc gtctgacctg cctcaacctc ctgtcaatgc tggcggcggc     1440

tctggtggtg gttctggtgg cggctctgag ggtggtggct ctgagggtgg cggttctgag     1500

ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga ttttgattat     1560

gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga aaacgcgcta     1620

cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc tgctatcgat     1680

ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg tgattttgct     1740

ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt aatgaataat     1800

ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt tgtctttggc     1860

gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt ccgtggtgtc     1920

tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt tgctaacata     1980

ctgcgtaata aggagtctta ataagcttga cctgtgaagt gaaaaatggc gcacattgtg     2040

cgacattttt tttgtctgcc gtttaccgct actgcgtcac ggatctccac gcgccctgta     2100

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     2160

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     2220

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     2280

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat     2340

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     2400

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc     2460

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta     2520

acaaaatatt aacgcttaca atttcaggtg gcacttttcg gggaaatgtg cgcggaaccc     2580

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct     2640

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg     2700

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg     2760

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc     2820

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca     2880

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac     2940

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa     3000

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg     3060

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt     3120

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg     3180

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc     3240

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaattg atagactgga     3300

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta     3360

ttgctgataa atctggagcc ggtgagcgtg gctctcgcgg tatcattgca gcactggggc     3420

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg     3480

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaggaat     3540

taatgatgtc tcgtttagat aaaagtaaag tgattaacag cgcattagag ctgcttaatg     3600

aggtcggaat cgaaggttta acaacccgta aactcgccca gaagctaggt gtagagcagc     3660

ctacattgta ttggcatgta aaaaataagc gggctttgct cgacgcctta gccattgaga     3720

tgttagatag gcaccatact cacttttgcc ctttagaagg ggaaagctgg caagattttt     3780

tacgtaataa cgctaaaagt tttagatgtg ctttactaag tcatcgcgat ggagcaaaag     3840

tacatttagg tacacggcct acagaaaaac agtatgaaac tctcgaaaat caattagcct     3900

ttttatgcca acaaggtttt tcactagaga atgcattata tgcactcagc gcagtggggc     3960

attttacttt aggttgcgta ttggaagatc aagagcatca agtcgctaaa gaagaaaggg     4020

aaacacctac tactgatagt atgccgccat tattacgaca agctatcgaa ttatttgatc     4080

accaaggtgc agagccagcc ttcttattcg gccttgaatt gatcatatgc ggattagaaa     4140

aacaacttaa atgtgaaagt gggtcttaaa agcagcataa cctttttccg tgatggtaac     4200

ttcactagtt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc     4260

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt     4320

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac     4380

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct     4440

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact     4500

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg     4560

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata     4620

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga     4680

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag     4740

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg     4800

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac     4860

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca     4920

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg acccgaca       4978


<210>  21
<211>  3760
<212>  DNA
<213>  Artificial

<220>
<223>  plasmid pa1m2

<400>  21
ccatcgaatg gccagatgat taattcctaa tttttgttga cactctatca ttgatagagt       60

tattttacca ctccctatca gtgatagaga aaagtgaaat gaatagttcg acaaaaatct      120

agataacgag ggcaaaaaat gaaaaagaca gctatcgcga ttgcagtggc actggctggt      180

ttcgctaccg tagcgcaggc cggccctgtg ccaacgccgc ccgacaatat ccaagtgcag      240

gaaaacttca atatctccca gatctatggg aagtggtaca acctggccat cggttccacc      300

agcccctggc tgaagaagat catggacagg atgacagtga gcacgctggt gctgggagag      360

ggcgctacag aggcggagat cagcatgacc agcactcgtt ggcggaaagg tgtctgtgag      420

gagacgtctg gagcttatga gaaaacagat actgatggga agtttctcta tcacaaatcc      480

aaatggaaca taaccatgga gtcctatgtg gtccacacca actatgatga gtatgccatt      540

ttcctgacca agaaattcag ccgccatcat ggacccacca ttactgccaa gctctacggg      600

cgggcgccgc agctgaggga aactctcctg caggacttca gagtggttgc ccagggtgtt      660

ggcatccctg aggactccat cttcaccatg gctgaccgag gtgaatgtgt ccctggggag      720

caggaaccag agcccatctt aatcccgaga agcgcttggt ctcacccgca gttcgaaaaa      780

taataagctt gacctgtgaa gtgaaaaatg gcgcacattg tgcgacattt tttttgtctg      840

ccgtttaccg ctactgcgtc acggatctcc acgcgccctg tagcggcgca ttaagcgcgg      900

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc      960

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     1020

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     1080

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     1140

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     1200

accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt     1260

taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgttta     1320

caatttcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     1380

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat     1440

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     1500

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     1560

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     1620

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     1680

gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact     1740

attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca     1800

tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact     1860

tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg     1920

atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg     1980

agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg     2040

aactacttac tctagcttcc cggcaacaat tgatagactg gatggaggcg gataaagttg     2100

caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag     2160

ccggtgagcg tggctctcgc ggtatcattg cagcactggg gccagatggt aagccctccc     2220

gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga     2280

tcgctgagat aggtgcctca ctgattaagc attggtagga attaatgatg tctcgtttag     2340

ataaaagtaa agtgattaac agcgcattag agctgcttaa tgaggtcgga atcgaaggtt     2400

taacaacccg taaactcgcc cagaagctag gtgtagagca gcctacattg tattggcatg     2460

taaaaaataa gcgggctttg ctcgacgcct tagccattga gatgttagat aggcaccata     2520

ctcacttttg ccctttagaa ggggaaagct ggcaagattt tttacgtaat aacgctaaaa     2580

gttttagatg tgctttacta agtcatcgcg atggagcaaa agtacattta ggtacacggc     2640

ctacagaaaa acagtatgaa actctcgaaa atcaattagc ctttttatgc caacaaggtt     2700

tttcactaga gaatgcatta tatgcactca gcgcagtggg gcattttact ttaggttgcg     2760

tattggaaga tcaagagcat caagtcgcta aagaagaaag ggaaacacct actactgata     2820

gtatgccgcc attattacga caagctatcg aattatttga tcaccaaggt gcagagccag     2880

ccttcttatt cggccttgaa ttgatcatat gcggattaga aaaacaactt aaatgtgaaa     2940

gtgggtctta aaagcagcat aacctttttc cgtgatggta acttcactag tttaaaagga     3000

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     3060

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     3120

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     3180

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     3240

caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     3300

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     3360

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     3420

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     3480

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     3540

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     3600

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     3660

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     3720

tcctggcctt ttgctggcct tttgctcaca tgacccgaca                           3760


<210>  22
<211>  173
<212>  PRT
<213>  Human

<400>  22

Ala Ser Pro Ile Ser Thr Ile Gln Pro Lys Ala Asn Phe Asp Ala Gln 
1               5                   10                  15      


Gln Phe Ala Gly Thr Trp Leu Leu Val Ala Val Gly Ser Ala Ala Arg 
            20                  25                  30          


Phe Leu Gln Glu Gln Gly His Arg Ala Glu Ala Thr Thr Leu His Val 
        35                  40                  45              


Ala Pro Gln Gly Thr Ala Met Ala Val Ser Thr Phe Arg Lys Leu Asp 
    50                  55                  60                  


Gly Ile Cys Trp Gln Val Arg Gln Leu Tyr Gly Asp Thr Gly Val Leu 
65                  70                  75                  80  


Gly Arg Phe Leu Leu Gln Ala Arg Gly Ala Arg Gly Ala Val His Val 
                85                  90                  95      


Val Val Ala Glu Thr Asp Tyr Gln Ser Phe Ala Val Leu Tyr Leu Glu 
            100                 105                 110         


Arg Ala Gly Gln Leu Ser Val Lys Leu Tyr Ala Arg Ser Leu Pro Val 
        115                 120                 125             


Ser Asp Ser Val Leu Ser Gly Phe Glu Gln Arg Val Gln Glu Ala His 
    130                 135                 140                 


Leu Thr Glu Asp Gln Ile Phe Tyr Phe Pro Lys Tyr Gly Phe Cys Glu 
145                 150                 155                 160 


Ala Ala Asp Gln Phe His Val Leu Asp Glu Val Arg Arg 
                165                 170             


<210>  23
<211>  162
<212>  PRT
<213>  Human

<400>  23

Ser Val Gln Pro Asn Phe Gln Gln Asp Lys Phe Leu Gly Arg Trp Phe 
1               5                   10                  15      


Ser Ala Gly Leu Ala Ser Asn Ser Ser Trp Leu Arg Glu Lys Lys Ala 
            20                  25                  30          


Ala Leu Ser Met Ala Lys Ser Val Val Ala Pro Ala Thr Asp Gly Gly 
        35                  40                  45              


Leu Asn Leu Thr Ser Thr Phe Leu Arg Lys Asn Gln Cys Glu Thr Arg 
    50                  55                  60                  


Thr Met Leu Leu Gln Pro Ala Gly Ser Leu Gly Ser Tyr Ser Tyr Arg 
65                  70                  75                  80  


Ser Pro His Trp Gly Ser Thr Tyr Ser Val Ser Val Val Glu Thr Asp 
                85                  90                  95      


Tyr Asp Gln Tyr Ala Leu Leu Tyr Ser Gln Gly Ser Lys Gly Pro Gly 
            100                 105                 110         


Glu Asp Phe Arg Met Ala Thr Leu Tyr Ser Arg Thr Gln Thr Pro Arg 
        115                 120                 125             


Ala Glu Leu Lys Glu Lys Phe Thr Ala Phe Cys Lys Ala Gln Gly Phe 
    130                 135                 140                 


Thr Glu Asp Thr Ile Val Phe Leu Pro Gln Thr Asp Lys Cys Met Thr 
145                 150                 155                 160 


Glu Gln 
        


<210>  24
<211>  161
<212>  PRT
<213>  Human

<400>  24

Thr Ala Gln Ala Glu Val Leu Leu Gln Pro Asp Phe Asn Ala Glu Lys 
1               5                   10                  15      


Phe Ser Gly Leu Trp Tyr Val Val Ser Met Ala Ser Asp Cys Arg Val 
            20                  25                  30          


Phe Leu Gly Lys Lys Asp His Leu Ser Met Ser Thr Arg Ala Ile Arg 
        35                  40                  45              


Pro Thr Glu Glu Gly Gly Leu His Val His Met Glu Phe Pro Gly Ala 
    50                  55                  60                  


Asp Gly Cys Asn Gln Val Asp Ala Glu Tyr Leu Lys Val Gly Ser Glu 
65                  70                  75                  80  


Gly His Phe Arg Val Pro Ala Leu Gly Tyr Leu Asp Val Arg Ile Val 
                85                  90                  95      


Asp Thr Asp Tyr Ser Ser Phe Ala Val Leu Tyr Ile Tyr Lys Glu Leu 
            100                 105                 110         


Glu Gly Ala Leu Ser Thr Met Val Gln Leu Tyr Ser Arg Thr Gln Asp 
        115                 120                 125             


Val Ser Pro Gln Ala Leu Lys Ser Phe Gln Asp Phe Tyr Pro Thr Leu 
    130                 135                 140                 


Gly Leu Pro Lys Asp Met Met Val Met Leu Pro Gln Ser Asp Ala Cys 
145                 150                 155                 160 


Asn 
    


<210>  25
<211>  181
<212>  PRT
<213>  Gallus gallus

<400>  25

Thr Pro Val Gly Asp Gln Asp Glu Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Glu Pro Glu Arg Met Tyr Gly Lys Trp Tyr Asp Val Ala Val Gly Thr 
            20                  25                  30          


Thr Cys Lys Trp Met Lys Asn Tyr Lys Glu Lys Phe Ser Met Gly Thr 
        35                  40                  45              


Leu Val Leu Gly Pro Gly Pro Ser Ala Asp Gln Ile Ser Thr Ile Ser 
    50                  55                  60                  


Thr Arg Leu Arg Gln Gly Asp Cys Lys Arg Val Ser Gly Glu Tyr Gln 
65                  70                  75                  80  


Lys Thr Asp Thr Pro Gly Lys Tyr Thr Tyr Tyr Asn Pro Lys Trp Asp 
                85                  90                  95      


Val Ser Ile Lys Ser Tyr Val Leu Arg Thr Asn Tyr Glu Glu Tyr Ala 
            100                 105                 110         


Val Ile Leu Met Lys Lys Thr Ser Asn Phe Gly Pro Thr Thr Thr Leu 
        115                 120                 125             


Lys Leu Tyr Gly Arg Ser Pro Glu Leu Arg Glu Glu Leu Thr Glu Ala 
    130                 135                 140                 


Phe Gln Gln Leu Ala Leu Glu Met Gly Ile Pro Ala Asp Ser Val Phe 
145                 150                 155                 160 


Ile Leu Ala Asn Lys Gly Glu Cys Val Pro Gln Glu Thr Ala Thr Ala 
                165                 170                 175     


Pro Glu Glu Gln Arg 
            180     


<210>  26
<211>  181
<212>  PRT
<213>  Meleagris gallopavo

<400>  26

Thr Pro Ile Gly Asp Gln Asp Glu Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Glu Pro Glu Arg Met Tyr Gly Lys Trp Tyr Asp Val Ala Val Ala Thr 
            20                  25                  30          


Thr Cys Lys Trp Met Lys Asn Tyr Lys Glu Lys Phe Ser Met Gly Thr 
        35                  40                  45              


Leu Val Leu Gly Pro Gly Pro Ser Thr Asp Gln Ile Ser Thr Ile Ser 
    50                  55                  60                  


Thr Arg Leu Arg Gln Gly Asp Cys Lys Arg Val Ser Gly Glu Tyr Gln 
65                  70                  75                  80  


Lys Thr Asp Thr Pro Gly Lys Tyr Thr Tyr Tyr Asn Pro Lys Trp Asp 
                85                  90                  95      


Val Ser Ile Lys Ser Tyr Val Leu Arg Thr Asn Tyr Glu Glu Tyr Ala 
            100                 105                 110         


Val Ile Leu Met Lys Lys Thr Ser Asn Phe Gly Pro Thr Thr Thr Leu 
        115                 120                 125             


Lys Leu Tyr Gly Arg Ser Pro Glu Leu Arg Glu Glu Leu Thr Glu Ala 
    130                 135                 140                 


Phe Gln Gln Leu Ala Leu Glu Met Gly Ile Pro Ala Asp Ser Ile Phe 
145                 150                 155                 160 


Ile Leu Ala Asn Lys Gly Glu Cys Val Pro Gln Glu Thr Ala Asn Ala 
                165                 170                 175     


Pro Glu Glu Gln Arg 
            180     


<210>  27
<211>  183
<212>  PRT
<213>  Pongo abelii

<400>  27

Gly Pro Val Pro Thr Pro Pro Asp Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Ile Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn 
                85                  90                  95      


Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Lys Phe Ser Arg Arg His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ile Leu Ile Pro Arg 
            180             


<210>  28
<211>  183
<212>  PRT
<213>  Nomascus leucogenys

<400>  28

Ser Cys Val Pro Cys Pro His Pro Gly Leu Thr Val Asp Arg His Leu 
1               5                   10                  15      


Gly Trp His Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Met Thr Val Ser Thr 
        35                  40                  45              


Leu Val Leu Arg Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Thr Ser Gly Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn 
                85                  90                  95      


Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Lys Phe Ser Arg Arg His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Ala Pro Gln Leu Arg Glu Thr Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Ile Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ile Leu Ile Pro Arg 
            180             


<210>  29
<211>  183
<212>  PRT
<213>  Callithrix jacchus

<400>  29

Gly Pro Val Pro Thr Pro Pro Glu Gly Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Leu Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Lys Ile Met Asp Arg Leu Lys Val Ser Thr 
        35                  40                  45              


Leu Val Leu Glu Glu Gly Thr Thr Glu Val Glu Ile Asn Met Thr Ser 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Phe Cys Glu Gln Thr Ser Leu Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn 
                85                  90                  95      


Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Gln Leu Tyr Gly Arg Glu Pro Gln Leu Arg Asp Ser Leu Leu Gln 
    130                 135                 140                 


Asp Phe Arg Val Val Ala Gln Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Ile Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Gln Pro Ile Leu His Pro Arg 
            180             


<210>  30
<211>  183
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  30

Asp Pro Val Pro Thr Leu Pro Asp Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Glu Leu Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Val Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Arg Ile Lys Asp Arg Met Ala Val Ser Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Thr Ser Glu Thr Glu Ile Ser Met Thr Ser 
    50                  55                  60                  


Thr His Trp Arg Arg Gly Val Cys Glu Glu Ile Ser Gly Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Ala Lys Trp Asn 
                85                  90                  95      


Leu Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Lys Phe Ser Arg Arg His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Glu Ser Leu Leu Gln 
    130                 135                 140                 


Glu Phe Arg Glu Val Ala Leu Gly Val Gly Ile Pro Glu Asn Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ile Asp Arg Gly Glu Cys Val Pro Gly Gln Gln Glu Pro 
                165                 170                 175     


Lys Pro Ala Pro Val Leu Arg 
            180             


<210>  31
<211>  182
<212>  PRT
<213>  Mus musculus

<400>  31

Asp Pro Ala Ser Thr Leu Pro Asp Ile Gln Val Gln Glu Asn Phe Ser 
1               5                   10                  15      


Glu Ser Arg Ile Tyr Gly Lys Trp Tyr Asn Leu Ala Val Gly Ser Thr 
            20                  25                  30          


Cys Pro Trp Leu Ser Arg Ile Lys Asp Lys Met Ser Val Ser Thr Leu 
        35                  40                  45              


Val Leu Gln Glu Gly Ala Thr Glu Thr Glu Ile Ser Met Thr Ser Thr 
    50                  55                  60                  


Arg Trp Arg Arg Gly Val Cys Glu Glu Ile Thr Gly Ala Tyr Gln Lys 
65                  70                  75                  80  


Thr Asp Ile Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile 
                85                  90                  95      


Thr Leu Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile 
            100                 105                 110         


Phe Leu Thr Lys Lys Ser Ser His His His Gly Leu Thr Ile Thr Ala 
        115                 120                 125             


Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Asp Ser Leu Leu Gln Glu 
    130                 135                 140                 


Phe Lys Asp Val Ala Leu Asn Val Gly Ile Ser Glu Asn Ser Ile Ile 
145                 150                 155                 160 


Phe Met Pro Asp Arg Gly Glu Cys Val Pro Gly Asp Arg Glu Val Glu 
                165                 170                 175     


Pro Thr Ser Ile Ala Arg 
            180         


<210>  32
<211>  182
<212>  PRT
<213>  Rattus norvegicus

<400>  32

Asp Asn Val Pro Thr Leu Pro Asp Ile Gln Val Gln Glu Asn Phe Asn 
1               5                   10                  15      


Glu Ala Arg Ile Tyr Gly Lys Trp Phe Asn Leu Ala Val Gly Ser Thr 
            20                  25                  30          


Cys Pro Trp Leu Arg Arg Ile Lys Asn Lys Met Ser Val Ser Thr Leu 
        35                  40                  45              


Val Leu Gln Glu Gly Ala Thr Glu Ala Glu Ile Ser Val Thr Ser Thr 
    50                  55                  60                  


Gln Trp Arg Lys Gly Val Cys Glu Glu Ile Ser Gly Val Tyr Gln Lys 
65                  70                  75                  80  


Thr Asp Ile Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ala 
                85                  90                  95      


Thr Leu Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile 
            100                 105                 110         


Phe Leu Thr Lys Lys Phe Ser His Arg His Gly Pro Thr Ile Thr Ala 
        115                 120                 125             


Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Asp Ser Leu Leu Gln Glu 
    130                 135                 140                 


Phe Arg Glu Val Ala Leu Ser Val Gly Ile Pro Glu Asn Ser Ile Val 
145                 150                 155                 160 


Phe Met Ala Asp Arg Gly Glu Cys Val Pro Gly Asp Arg Glu Val Glu 
                165                 170                 175     


Ser Thr Ser Phe Ala Arg 
            180         


<210>  33
<211>  182
<212>  PRT
<213>  Meriones unguiculatus

<400>  33

Asp Asp Ala Ala Thr Leu Pro Asp Ile Gln Val Gln Glu Asn Phe Ile 
1               5                   10                  15      


Glu Ser Leu Ile Tyr Gly Lys Trp Phe Asn Leu Ala Val Gly Ser Thr 
            20                  25                  30          


Cys Pro Trp Leu Arg Arg Ile Lys Asp Lys Met Ser Met Ser Thr Leu 
        35                  40                  45              


Val Leu Gln Glu Gly Ala Thr Glu Ala Glu Ile Ser Met Thr Ser Thr 
    50                  55                  60                  


Arg Trp Arg Arg Gly Val Cys Glu Glu Ile Ser Gly Ala Tyr Glu Lys 
65                  70                  75                  80  


Thr Asp Ile Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Ile 
                85                  90                  95      


Thr Leu Glu Thr Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile 
            100                 105                 110         


Phe Leu Thr Lys Lys Phe Ser His Tyr His Gly Pro Thr Ile Thr Leu 
        115                 120                 125             


Lys Leu Tyr Gly Arg Glu Pro Lys Leu Arg Asp Ser Leu Leu Leu Glu 
    130                 135                 140                 


Phe Arg Glu Val Ala Leu Ser Met Gly Ile Pro Glu Asn Ser Ile Val 
145                 150                 155                 160 


Phe Met Ala Asp Lys Gly Glu Cys Val Pro Gly Asp Gln Glu Val Lys 
                165                 170                 175     


Pro Ser Pro His Leu Arg 
            180         


<210>  34
<211>  182
<212>  PRT
<213>  Mesocricetus auratus

<400>  34

Asp Pro Val Pro Ala Leu Pro Asp Ile Gln Val Gln Glu Asn Phe Asn 
1               5                   10                  15      


Glu Ser Arg Ile Tyr Gly Lys Trp Phe Asn Leu Ala Val Gly Ser Thr 
            20                  25                  30          


Cys Pro Trp Leu Ser Arg Ile Lys Asn Lys Met Ser Met Ser Thr Leu 
        35                  40                  45              


Val Leu Arg Glu Gly Ala Thr Gly Ala Glu Ile Ser Thr Thr Ser Thr 
    50                  55                  60                  


Arg Trp Arg Arg Gly Val Cys Glu Glu Val Ser Gly Thr Tyr Glu Lys 
65                  70                  75                  80  


Thr Asp Met Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn Val 
                85                  90                  95      


Thr Leu Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile 
            100                 105                 110         


Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr Ala 
        115                 120                 125             


Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Asp Ser Leu Leu Gln Glu 
    130                 135                 140                 


Phe Arg Glu Val Ala Leu Ser Val Gly Ile Pro Glu Asn Ser Ile Val 
145                 150                 155                 160 


Phe Met Glu Asp Arg Gly Glu Cys Val Pro Gly Asp Leu Glu Gln Lys 
                165                 170                 175     


Ser Thr Ser Leu Leu Arg 
            180         


<210>  35
<211>  183
<212>  PRT
<213>  Bos taurus

<400>  35

Ser Ser Val Pro Thr Leu Pro Asp Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asp Leu Ser Arg Ile Tyr Gly Lys Trp Phe Asn Val Ala Val Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Arg Phe Lys Glu Lys Met Thr Met Ser Thr 
        35                  40                  45              


Val Val Leu Ile Ala Gly Pro Thr Ser Lys Glu Ile Ser Val Thr Asn 
    50                  55                  60                  


Thr His Arg Arg Lys Gly Val Cys Glu Ser Ile Ser Gly Thr Tyr Glu 
65                  70                  75                  80  


Lys Thr Ser Ala Asp Gly Lys Phe Leu Tyr His Lys Ala Lys Trp Asn 
                85                  90                  95      


Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Lys Leu Ser Arg Arg His Gly Pro Thr Ile Thr 
        115                 120                 125             


Val Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Glu Ser Leu Leu Glu 
    130                 135                 140                 


Glu Phe Arg Glu Val Ala Leu Gly Val Gly Ile Pro Glu Asp Ala Ile 
145                 150                 155                 160 


Phe Thr Met Pro Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Asp Pro 
                165                 170                 175     


Val Pro Thr Pro Leu Ser Arg 
            180             


<210>  36
<211>  183
<212>  PRT
<213>  Sus scrofa

<400>  36

Ser Pro Val Leu Thr Leu Pro Asn Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asp Leu Ser Arg Ile Tyr Gly Lys Trp Phe His Val Ala Val Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Arg Phe Lys Asp Lys Met Thr Met Gly Thr 
        35                  40                  45              


Leu Met Leu Gly Glu Gly Ala Thr Glu Arg Glu Ile Ser Val Thr Lys 
    50                  55                  60                  


Thr His Arg Arg Lys Gly Ile Cys Glu Val Ile Ser Gly Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Ser Thr Asp Gly Lys Phe Leu Tyr His Lys Ser Lys Trp Asn 
                85                  90                  95      


Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Lys Phe Ser Arg Arg His Gly Pro Thr Leu Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Glu Ser Leu Leu Glu 
    130                 135                 140                 


Glu Phe Arg Glu Val Ala Leu Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Pro Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Thr Leu Leu Ser Arg 
            180             


<210>  37
<211>  183
<212>  PRT
<213>  Ailuropoda melanoleuca

<400>  37

Ser Pro Val Leu Thr Pro Pro Asp Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asp Ile Ser Arg Met Tyr Gly Lys Trp Phe His Val Ala Met Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Lys Phe Met Asp Arg Met Ser Met Ser Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Asp Gly Glu Ile Ser Met Thr Ser 
    50                  55                  60                  


Thr Arg Trp Arg Arg Gly Ala Cys Glu Glu Ile Ser Gly Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Ser Thr Asn Gly Lys Phe Leu Tyr His Lys Pro Lys Trp Asn 
                85                  90                  95      


Met Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Gln Pro Gln Leu Arg Glu Ser Leu Leu Glu 
    130                 135                 140                 


Glu Phe Arg Glu Val Ala Leu Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Lys Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ser Pro His Arg Arg 
            180             


<210>  38
<211>  183
<212>  PRT
<213>  Felis catus

<400>  38

Ser Pro Val Leu Thr Pro Pro Asp Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asp Ile Ser Arg Ile Tyr Gly Lys Trp Phe His Val Ala Met Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Lys Phe Met Asp Arg Met Ser Met Ser Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Lys Asp Lys Glu Ile Ser Met Thr Ser 
    50                  55                  60                  


Thr Arg Trp Arg Arg Gly Thr Cys Glu Glu Ile Ser Gly Ala Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Asp Gly Lys Phe Leu Tyr His Lys Pro Arg Trp Asn 
                85                  90                  95      


Ile Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Leu Leu Thr Lys Lys Phe Ser His His His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Gln Pro Gln Leu Arg Glu Ser Leu Leu Glu 
    130                 135                 140                 


Glu Phe Arg Glu Val Ala Leu Gly Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Lys Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ser Pro Leu Thr Arg 
            180             


<210>  39
<211>  183
<212>  PRT
<213>  Canis familiaris

<400>  39

Ser Pro Val Leu Thr Pro Pro Asp Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asp Val Ser Arg Ile Tyr Gly Lys Trp Phe His Val Ala Val Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Lys Phe Met Asp Arg Met Ser Met Ser Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Pro Thr Asp Arg Glu Leu Ser Met Thr Ser 
    50                  55                  60                  


Thr Arg Trp Arg Arg Gly Thr Cys Glu Glu Ile Ser Gly Thr Tyr Glu 
65                  70                  75                  80  


Ile Thr Gly Thr Ser Gly Lys Phe Leu Tyr His Lys Pro Lys Trp Asn 
                85                  90                  95      


Leu Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Gln Pro Gln Leu Arg Glu Ser Leu Leu Glu 
    130                 135                 140                 


Glu Phe Arg Glu Val Ala Leu Gly Val Gly Ile Pro Ala Asp Ala Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Lys Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Ser Pro Tyr Met Arg 
            180             


<210>  40
<211>  183
<212>  PRT
<213>  Equus caballus

<400>  40

Ser Pro Val Pro Thr Pro Pro Ala Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asp Leu Ser Arg Ile Tyr Gly Lys Trp Phe Leu Val Ala Met Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Lys Ile Lys Asp Arg Met Thr Ile Ser Thr 
        35                  40                  45              


Leu Val Leu Gly Glu Gly Ala Thr Asp Gly Glu Ile Ser Thr Thr Ser 
    50                  55                  60                  


Thr Arg Trp Arg Lys Gly Val Cys Glu Glu Ile Ser Gly Thr Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Lys Gly Lys Phe Arg Tyr His Lys Ser Lys Trp Asn 
                85                  90                  95      


Leu Ser Ile Glu Ser Tyr Val Val Gln Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Phe Leu Ser Lys Lys Phe Ser Arg Arg His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Asp Arg Gln Leu Arg Glu Ser Leu Leu Asp 
    130                 135                 140                 


Thr Phe Arg Glu Val Ala Leu Gly Val Gly Ile Pro Gly Asp Ser Ile 
145                 150                 155                 160 


Val Thr Leu Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Glu Pro Met Pro Phe Ser Arg 
            180             


<210>  41
<211>  183
<212>  PRT
<213>  Myotis lucifugus

<400>  41

Asn Pro Val Pro Thr Pro Pro Ala Asn Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asp Val Ser Arg Phe Tyr Gly Lys Trp Phe His Val Ala Ile Gly Ser 
            20                  25                  30          


Thr Cys Ser Trp Leu Val Arg Phe Lys Asp Arg Leu Thr Val Ser Thr 
        35                  40                  45              


Leu Leu Leu Arg Glu Gly Glu Thr Glu Arg Gln Ile Ser Thr Thr Ile 
    50                  55                  60                  


Thr Arg Trp Arg Arg Gly Val Cys Glu Glu His Ser Gly Thr Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Glu Gly Lys Phe Leu Tyr His Arg Ser Arg Arg Asn 
                85                  90                  95      


Ile Asn Ile Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Ile Leu Ser Lys Lys Ser Ser Ser His His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Gly Pro Gln Leu Arg Glu Ser Leu Leu Gln 
    130                 135                 140                 


Glu Phe Arg Glu Val Ala Leu Gly Val Gly Ile Pro Glu Asp Ala Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asp Arg Gly Glu Cys Val Pro Gly Glu Gln Glu Pro 
                165                 170                 175     


Asp Leu Thr Ser Ser Ser Arg 
            180             


<210>  42
<211>  183
<212>  PRT
<213>  Cavia porcellus

<400>  42

Asn Pro Val Leu Thr Leu Pro Asp Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asp Glu Ser Arg Met Tyr Gly Lys Trp Tyr Ser Leu Ala Ile Gly Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Arg Ile Lys Asp Arg Leu Ser Val Asp Thr 
        35                  40                  45              


Met Val Leu Gly Lys Gly Ala Thr Glu Ala Gln Met Ser Thr Thr Arg 
    50                  55                  60                  


Thr His Trp Arg Arg Gly Val Cys Glu Arg Thr Ser Gly Phe Tyr Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Ala Gly Lys Tyr Leu Tyr Ser Asn Pro Lys Trp Asn 
                85                  90                  95      


Leu Thr Met Glu Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Thr Val Leu Thr Lys Lys Phe Ser Arg His His Gly Pro Thr Ile Thr 
        115                 120                 125             


Ala Lys Leu Tyr Gly Arg Glu Pro Gln Leu Arg Asp Ser Leu Leu Gln 
    130                 135                 140                 


Gly Phe Arg Glu Met Ala Leu Ser Val Gly Ile Pro Glu Asp Ser Ile 
145                 150                 155                 160 


Phe Thr Met Ala Asn Arg Gly Glu Cys Ile Pro Gly Glu Gln Ile Pro 
                165                 170                 175     


Gln Pro Thr Pro Ala Leu Arg 
            180             


<210>  43
<211>  187
<212>  PRT
<213>  Monodelphis domestica

<400>  43

Gly Asn Pro Val Ser Ile Gln Asp Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asn Leu Ser Arg Ile Phe Gly Lys Trp Tyr Asp Ile Ala Met Ala Ser 
            20                  25                  30          


Asn Cys Pro Trp Leu Lys Arg Leu Asn Arg Pro Leu Ser Met Gly Thr 
        35                  40                  45              


Leu Val Leu Gly Gln Gly Gln Thr Asp Gln Glu Ile Ser Thr Ile Arg 
    50                  55                  60                  


Thr Arg Phe Arg Lys Gly Val Cys Glu Gln Val Ser Asp Val His Glu 
65                  70                  75                  80  


Lys Thr Asp Thr Glu Gly Lys Phe Ser Tyr Tyr Asn Ser Lys Trp Asn 
                85                  90                  95      


Val Thr Met Glu Tyr Phe Val Val His Thr Asn Tyr Asp Glu Tyr Val 
            100                 105                 110         


Met Ile Leu Lys His Lys Leu Arg His Ser Gly Pro Ser Thr Thr Val 
        115                 120                 125             


Thr Leu Tyr Gly Arg Arg Pro Gln Ile Arg Asn Ser Leu Leu Glu Glu 
    130                 135                 140                 


Phe Lys Asp Phe Ala Leu Ser Leu Gly Ile Pro Glu Ser Ser Ile Tyr 
145                 150                 155                 160 


Phe Lys Leu Asp Lys Gly Glu Cys Val Pro Gly Glu Arg Glu Pro Val 
                165                 170                 175     


Pro Gln Pro Gln Val Ser Leu Ser Ala Ser Arg 
            180                 185         


<210>  44
<211>  179
<212>  PRT
<213>  Xenopus tropicalis

<400>  44

Ser Ser Pro Val Gln Thr Gln Glu Asp Ile Gln Val Gln Glu Asn Phe 
1               5                   10                  15      


Asp Leu Gln Lys Ile Tyr Gly Lys Trp Tyr Asp Val Ala Ile Gly Ser 
            20                  25                  30          


Thr Cys Lys Trp Leu Lys Leu His Lys Asp Lys Leu Asn Met Gly Thr 
        35                  40                  45              


Leu Glu Leu Ser Glu Gly Glu Ala Asp Gly Glu Val Arg Ile Val Asn 
    50                  55                  60                  


Thr Arg Met Arg His Gly Thr Cys Ser Gln Ile Val Gly Ala Tyr Gln 
65                  70                  75                  80  


Lys Thr Glu Thr Pro Gly Lys Phe Asp Tyr Phe Asn Gln Arg Trp Gly 
                85                  90                  95      


Thr Thr Ile Gln Asn Tyr Ile Val Phe Thr Asn Tyr Asn Glu Tyr Ala 
            100                 105                 110         


Ile Met Leu Met Arg Lys Lys Lys Gly Thr Glu Thr Thr Thr Thr Val 
        115                 120                 125             


Lys Leu Tyr Gly Arg Ser Pro Asp Leu Arg Pro Val Leu Ile Asp Glu 
    130                 135                 140                 


Phe Gln Gln Phe Ala Leu Ala Gln Gly Val Pro Glu Asp Ser Ile Phe 
145                 150                 155                 160 


Thr Leu Thr Asn Ser Gly Glu Cys Ala Pro Gly Asp Ile Glu Val Arg 
                165                 170                 175     


Pro Arg Arg 
            


<210>  45
<211>  179
<212>  PRT
<213>  Xenopus laevis

<400>  45

Cys Ser Pro Ile Gln Pro Glu Asp Asn Ile Gln Ile Gln Glu Asn Phe 
1               5                   10                  15      


Asp Leu Gln Arg Ile Tyr Gly Lys Trp Tyr Asp Ile Ala Ile Gly Ser 
            20                  25                  30          


Thr Cys Lys Trp Leu Lys His His Lys Glu Lys Phe Asn Met Gly Thr 
        35                  40                  45              


Leu Glu Leu Ser Asp Gly Glu Thr Asp Gly Glu Val Arg Ile Val Asn 
    50                  55                  60                  


Thr Arg Met Arg His Gly Thr Cys Ser Gln Ile Val Gly Ser Tyr Gln 
65                  70                  75                  80  


Lys Thr Glu Thr Pro Gly Lys Phe Asp Tyr Phe Asn Ala Arg Trp Gly 
                85                  90                  95      


Thr Thr Ile Gln Asn Tyr Ile Val Phe Thr Asn Tyr Asn Glu Tyr Val 
            100                 105                 110         


Ile Met Gln Met Arg Lys Lys Lys Gly Ser Glu Thr Thr Thr Thr Val 
        115                 120                 125             


Lys Leu Tyr Gly Arg Ser Pro Asp Leu Arg Pro Thr Leu Val Asp Glu 
    130                 135                 140                 


Phe Arg Gln Phe Ala Leu Ala Gln Gly Ile Pro Glu Asp Ser Ile Val 
145                 150                 155                 160 


Met Leu Pro Asn Asn Gly Glu Cys Ser Pro Gly Glu Ile Glu Val Arg 
                165                 170                 175     


Pro Arg Arg 
            


<210>  46
<211>  183
<212>  PRT
<213>  Ctenopharyngodon idella

<400>  46

Ala Gly Pro Leu Pro Asp Glu Pro Val Leu Gln Thr Gln Glu Asn Phe 
1               5                   10                  15      


Asp Val Thr Arg Phe Met Gly Lys Trp Tyr Asp Ile Ala Met Ala Ser 
            20                  25                  30          


Thr Cys Pro Trp Leu Lys Arg His Lys Gly Asp Ala Ala Ile Gly Ser 
        35                  40                  45              


Met Glu Leu Gln Tyr Ser Ala Ser Thr Gln Thr Ile Ser Val Thr Arg 
    50                  55                  60                  


Ile Gly Leu Arg His Gly Thr Cys Lys Ser Ile Ser Gly Glu Tyr Gln 
65                  70                  75                  80  


Leu Thr Lys Thr Pro Gly Arg Phe His Tyr His Ile Ala Lys Trp Asn 
                85                  90                  95      


Ala Asp Val Asp Ser Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Leu Val Val Met Tyr Lys Gln Lys Thr Gly Gly Glu Lys Ser Thr Ser 
        115                 120                 125             


Val Lys Leu Tyr Gly Arg Thr Met Gln Leu Arg Pro Thr Leu Ile Glu 
    130                 135                 140                 


Glu Phe Lys Thr Leu Val Ala Glu Gln Gly Met Ser Glu Asp Thr Ile 
145                 150                 155                 160 


Val Ile Lys Lys Asn Lys Gly Glu Cys Val Pro Gly Glu Gln Ala Thr 
                165                 170                 175     


Pro Glu Pro Gln Ile Gln Arg 
            180             


<210>  47
<211>  183
<212>  PRT
<213>  Danio rerio

<400>  47

Ala Gly Pro Leu Pro Asp Glu Pro Val Leu Gln Thr Gln Glu Asn Phe 
1               5                   10                  15      


Asn Val Asn Arg Phe Met Gly Lys Trp Tyr Asp Ile Ala Val Ala Ser 
            20                  25                  30          


Thr Cys Pro Trp Met Lys Arg His Lys Gly Asp Ala Ala Ile Gly Ser 
        35                  40                  45              


Leu Glu Leu Gln Ser Ser Gly Ser Pro Gln Ser Leu Ser Met Thr Arg 
    50                  55                  60                  


Ile Gly Leu Arg Arg Gly Thr Cys Lys Ser Ile Ser Gly Glu Tyr Gln 
65                  70                  75                  80  


Leu Thr Lys Thr Pro Gly Arg Phe His Tyr His Ser Ala Lys Trp Asn 
                85                  90                  95      


Ser Asp Val Asp Ala Tyr Val Val His Thr Asn Tyr Asn Glu Tyr Ala 
            100                 105                 110         


Leu Val Val Met Leu Lys Gln Lys Pro Gly Gly Glu Lys Ser Thr Ser 
        115                 120                 125             


Val Lys Leu Tyr Gly Arg Thr Met Glu Leu Arg Pro Thr Leu Ile Glu 
    130                 135                 140                 


Asp Phe Lys Thr Leu Val Ala Glu Gln Gly Met Ser Glu Asp Thr Ile 
145                 150                 155                 160 


Ile Ile Lys Lys Asn Lys Gly Glu Cys Val Pro Gly Glu Glu Thr Thr 
                165                 170                 175     


Pro Glu Pro Gln Ile Gln Arg 
            180             


<210>  48
<211>  188
<212>  PRT
<213>  Oncorhynchus mykiss

<400>  48

Gly Val Pro Leu Leu Pro Glu Pro Leu Phe Pro Thr Gln Glu Asn Phe 
1               5                   10                  15      


Asp Leu Thr Lys Phe Met Gly Lys Trp His Asp Ile Ala Val Ala Ser 
            20                  25                  30          


Thr Trp Pro Trp Met Gln Arg His Lys Gly Asp Ala Ala Ile Gly Ile 
        35                  40                  45              


Leu Glu Leu Gln Ala Ser Gly Thr Glu Asp Lys Val Ser Met Thr Arg 
    50                  55                  60                  


Ser Met Asn Lys His Gly Thr Cys Gln Gln Ile Ser Gly Asp Tyr Lys 
65                  70                  75                  80  


Leu Thr Asp Thr Pro Gly Arg Phe Thr Tyr His Ile Ala Lys Trp Gly 
                85                  90                  95      


Ala Asp Val Asp Ala Tyr Val Val Asp Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Val Met Ile Ser Lys Gln Lys Thr Glu Gly Glu Lys Thr Lys Ser 
        115                 120                 125             


Ala Lys Leu Tyr Ser Arg Thr Met Glu Leu Ser Pro Ala Ile Leu Glu 
    130                 135                 140                 


Asp Phe Arg Arg Leu Val Arg Glu Gln Gly Met Asp Asp Asn Thr Ile 
145                 150                 155                 160 


Ile Ile Lys Gln Asn Lys Gly Glu Cys Val Pro Gly Thr Glu Pro Val 
                165                 170                 175     


Ala Ser Glu Pro Gln Pro Glu Ile Thr Ala Pro Arg 
            180                 185             


<210>  49
<211>  188
<212>  PRT
<213>  Salmo salar

<400>  49

Gly Val Pro Val Leu Ala Glu Pro Leu Phe Pro Thr Gln Glu Asn Phe 
1               5                   10                  15      


Asp Leu Ser Lys Phe Met Gly Lys Trp His Asp Ile Ala Val Ala Ser 
            20                  25                  30          


Thr Cys Pro Trp Ile Gln Arg His Arg Gly Asp Ala Ala Ile Gly Ile 
        35                  40                  45              


Leu Glu Leu Gln Ala Gly Asp Thr Glu Gly Lys Val Ser Met Lys Arg 
    50                  55                  60                  


Ser Met Lys Lys His Gly Thr Cys Lys Gln Ile Ser Gly Asp Tyr Glu 
65                  70                  75                  80  


Leu Thr Asp Thr Pro Gly Arg Phe Thr Tyr His Val Ala Lys Trp Gly 
                85                  90                  95      


Ala Asp Val Asp Ala Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Val Met Met Ser Lys Gln Lys Thr Gly Gly Glu Lys Thr Lys Ser 
        115                 120                 125             


Ala Lys Leu Tyr Ser Arg Thr Met Glu Leu Arg Thr Thr Ile Leu Asp 
    130                 135                 140                 


Asp Phe Arg Arg Leu Val Arg Glu Gln Gly Met Ala Asp Asp Thr Val 
145                 150                 155                 160 


Ile Ile Lys Gln Asn Lys Gly Glu Cys Ile Pro Gly Ala Glu Pro Val 
                165                 170                 175     


Ala Ala Glu Ser Gln Ser Glu Ile Thr Ala Pro Arg 
            180                 185             


<210>  50
<211>  186
<212>  PRT
<213>  Esox lucius

<400>  50

Gly Val Pro Val Leu Thr Asp Pro Leu Tyr Thr Thr Gln Glu Asn Phe 
1               5                   10                  15      


Asp Leu Ser Lys Phe Met Gly Lys Trp His Asp Ile Ala Met Ala Ser 
            20                  25                  30          


Thr Cys Pro Trp Met Gln Arg His Lys Gly Asp Ala Ala Ile Gly Thr 
        35                  40                  45              


Leu Glu Leu Gln Thr Gly Ser Thr Glu Gly Lys Ile Ser Met Thr Arg 
    50                  55                  60                  


Lys Met Lys Lys Leu Gly Thr Cys Lys Gln Ile Ser Gly Glu Tyr Gln 
65                  70                  75                  80  


Ile Thr Asp Thr Pro Gly Arg Phe Thr Tyr His Val Ala Lys Trp Gly 
                85                  90                  95      


Ala Asp Val Asp Ala Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala 
            100                 105                 110         


Ile Val Leu Met Ser Lys Gln Lys Thr Gly Gly Glu Lys Thr Lys Ser 
        115                 120                 125             


Ala Lys Leu Tyr Ser Arg Thr Met Glu Val Arg Asp Thr Ile Leu Asp 
    130                 135                 140                 


Asp Phe Lys Arg Leu Val Lys Glu Gln Gly Met Ala Asp Asp Thr Val 
145                 150                 155                 160 


Val Val Lys Gln Asn Lys Gly Glu Cys Ile Pro Gly Val Glu Thr Val 
                165                 170                 175     


Gln Thr Glu Pro Gln Pro Asp Ile Thr Arg 
            180                 185     


<210>  51
<211>  185
<212>  PRT
<213>  Pleuronectes platessa

<400>  51

Gly Leu Pro Val Leu Pro Glu Pro Leu Tyr Pro Thr Gln Glu Asn Phe 
1               5                   10                  15      


Asp Leu Thr Arg Phe Val Gly Thr Trp His Asp Val Ala Leu Thr Ser 
            20                  25                  30          


Ser Cys Pro His Met Gln Arg Asn Arg Ala Asp Ala Ala Ile Gly Lys 
        35                  40                  45              


Leu Val Leu Glu Lys Asp Thr Gly Asn Lys Leu Lys Val Thr Arg Thr 
    50                  55                  60                  


Arg Leu Arg His Gly Thr Cys Val Glu Met Ser Gly Glu Tyr Glu Leu 
65                  70                  75                  80  


Thr Ser Thr Pro Gly Arg Ile Phe Tyr His Ile Asp Arg Trp Asp Ala 
                85                  90                  95      


Asp Val Asp Ala Tyr Val Val His Thr Asn Tyr Asp Glu Tyr Ala Ile 
            100                 105                 110         


Ile Ile Met Ser Lys Gln Lys Thr Ser Gly Glu Asn Ser Thr Ser Leu 
        115                 120                 125             


Lys Leu Tyr Ser Arg Thr Met Ser Val Arg Asp Thr Val Leu Asp Asp 
    130                 135                 140                 


Phe Lys Thr Leu Val Arg His Gln Gly Met Ser Asp Asp Thr Ile Ile 
145                 150                 155                 160 


Ile Lys Gln Asn Lys Gly Asp Cys Ile Pro Gly Glu Gln Val Glu Glu 
                165                 170                 175     


Ala Pro Ser Gln Pro Glu Pro Lys Arg 
            180                 185 


