                         SEQUENCE LISTING

<110>  University of Rochester
 
<120>  COMPOSITIONS AND METHODS FOR RECOMBINANT SYNTHESIS OF HIGH 
       MOLECULAR WEIGHT HYALURONIC ACID

<130>  055652.00079

<150>  61/594,929
<151>  2012-02-03

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  552
<212>  PRT
<213>  naked mole rat

<400>  1

Met His Cys Glu Arg Phe Leu Cys Ile Leu Arg Ile Ile Gly Thr Thr 
1               5                   10                  15      


Leu Phe Gly Val Ser Leu Leu Leu Gly Ile Thr Ala Ala Tyr Ile Val 
            20                  25                  30          


Gly Tyr Gln Phe Ile Gln Thr Asp Asn Tyr Tyr Phe Ser Phe Gly Leu 
        35                  40                  45              


Tyr Gly Ala Phe Leu Ala Ser His Leu Ile Ile Gln Ser Leu Phe Ala 
    50                  55                  60                  


Phe Leu Glu His Arg Lys Met Lys Lys Ser Leu Glu Thr Pro Ile Lys 
65                  70                  75                  80  


Leu Asn Lys Thr Val Ala Leu Cys Ile Ala Ala Tyr Gln Glu Asp Pro 
                85                  90                  95      


Asp Tyr Leu Arg Lys Cys Leu Gln Ser Val Lys Arg Leu Thr Tyr Pro 
            100                 105                 110         


Gly Ile Lys Val Val Met Val Ile Asp Gly Asn Ser Asp Asp Asp Leu 
        115                 120                 125             


Tyr Met Met Asp Ile Phe Ser Glu Val Met Gly Arg Asp Lys Ser Ala 
    130                 135                 140                 


Thr Tyr Ile Trp Lys Asn Asn Phe His Glu Lys Gly Pro Gly Glu Thr 
145                 150                 155                 160 


Asp Glu Ser His Lys Glu Ser Ser Gln His Val Thr Gln Leu Val Leu 
                165                 170                 175     


Ser Ser Lys Ser Val Cys Ile Met Gln Lys Trp Gly Gly Lys Arg Glu 
            180                 185                 190         


Val Met Tyr Thr Ala Phe Arg Ala Leu Gly Arg Ser Val Asp Tyr Val 
        195                 200                 205             


Gln Val Cys Asp Ser Asp Thr Met Leu Asp Pro Ala Ser Ser Val Glu 
    210                 215                 220                 


Met Val Lys Val Leu Glu Glu Asp Pro Met Val Gly Gly Val Gly Gly 
225                 230                 235                 240 


Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile Ser Phe Leu Ser 
                245                 250                 255     


Ser Val Arg Tyr Trp Met Ala Phe Asn Ile Glu Arg Ala Cys Gln Ser 
            260                 265                 270         


Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu Gly Met Tyr Arg 
        275                 280                 285             


Asn Ser Leu Leu His Glu Phe Val Glu Asp Trp Tyr Ser Gln Glu Phe 
    290                 295                 300                 


Met Gly Asn Gln Cys Ser Phe Gly Asp Asp Arg His Leu Thr Asn Arg 
305                 310                 315                 320 


Val Leu Ser Leu Gly Tyr Ala Thr Lys Tyr Thr Ala Arg Ser Lys Cys 
                325                 330                 335     


Leu Thr Glu Thr Pro Ile Glu Tyr Leu Arg Trp Leu Asn Gln Gln Thr 
            340                 345                 350         


Arg Trp Ser Lys Ser Tyr Phe Arg Glu Trp Leu Tyr Asn Ala Met Trp 
        355                 360                 365             


Phe His Lys His His Leu Trp Met Thr Tyr Glu Ala Val Ile Thr Gly 
    370                 375                 380                 


Phe Phe Pro Phe Phe Leu Ile Ala Thr Val Ile Gln Leu Phe Tyr Arg 
385                 390                 395                 400 


Gly Lys Ile Trp Asn Ile Leu Leu Phe Leu Leu Thr Val Gln Leu Val 
                405                 410                 415     


Gly Leu Ile Lys Ser Ser Phe Ala Ser Cys Leu Arg Gly Asn Ile Ile 
            420                 425                 430         


Met Val Phe Met Ser Leu Tyr Ser Val Leu Tyr Met Ser Ser Leu Leu 
        435                 440                 445             


Pro Ala Lys Met Phe Ala Ile Ala Thr Ile Asn Lys Ala Gly Trp Gly 
    450                 455                 460                 


Thr Ser Gly Arg Lys Thr Ile Val Val Asn Phe Ile Gly Leu Ile Pro 
465                 470                 475                 480 


Val Ser Val Trp Phe Thr Ile Leu Leu Gly Gly Val Ile Phe Thr Ile 
                485                 490                 495     


Tyr Lys Glu Ser Lys Lys Pro Phe Ser Glu Ser Lys Gln Thr Val Leu 
            500                 505                 510         


Ile Val Gly Thr Leu Leu Tyr Ala Cys Tyr Trp Val Met Leu Leu Thr 
        515                 520                 525             


Leu Tyr Val Val Leu Ile Asn Lys Cys Gly Arg Arg Lys Lys Gly Gln 
    530                 535                 540                 


Gln Tyr Asp Met Val Leu Asp Val 
545                 550         


<210>  2
<211>  1659
<212>  DNA
<213>  naked mole rat

<400>  2
atgcattgtg agaggtttct atgtatcctg agaataattg gaaccacgct ttttggagtc       60

tctcttctcc ttggaatcac agctgcttat atcgttggct accagtttat ccaaacggac      120

aattactatt tctcttttgg attatatggt gcctttttag catcacatct catcatccaa      180

agcctatttg cctttttgga acacaggaaa atgaaaaaat ctctagaaac ccccattaag      240

ttgaacaaaa ctgttgctct ttgcatcgct gcatatcaag aagacccaga ctacttacga      300

aaatgtttgc aatctgtgaa aaggctcacc taccccggga ttaaggttgt catggtcata      360

gatgggaact cggatgatga cctgtacatg atggacatct tcagcgaagt catgggcagg      420

gacaagtcag ccacttacat ctggaaaaac aacttccacg aaaagggtcc tggtgagacg      480

gatgagtcac ataaagagag ctcacagcac gtgacacagt tggtcttgtc cagtaaaagt      540

gtgtgcatca tgcaaaagtg gggtggaaaa cgagaagtca tgtacacagc cttccgagcc      600

ctgggacgaa gtgtggatta tgtgcaggtt tgtgactccg ataccatgct ggaccctgcc      660

tcatctgtgg agatggtgaa agttttagaa gaagacccca tggttggagg agttgggggg      720

gatgtccaga ttttaaacaa gtatgattcc tggatctctt tcctcagcag tgtgagatac      780

tggatggctt ttaatataga aagggcctgt cagtcgtatt ttgggtgtgt ccagtgcatc      840

agtggacctc tgggaatgta cagaaactcc ctgctgcatg agtttgtgga agactggtac      900

agtcaagaat tcatgggcaa ccagtgtagt tttggagatg acaggcacct aacaaatcgg      960

gtgctgagtc tgggctatgc cacaaaatac acagctcggt ccaagtgcct tactgaaaca     1020

ccaatcgaat atctcagatg gttgaaccag cagacccgtt ggagcaagtc ctacttccga     1080

gagtggctgt acaatgcaat gtggttccac aagcatcact tgtggatgac ctatgaagca     1140

gtcatcactg gatttttccc tttctttctc attgccacag taatccagct cttctacagg     1200

gggaaaattt ggaacatcct tctcttcttg ctaactgtcc agctggtagg gctcataaaa     1260

tcatcttttg ccagctgcct cagaggaaac atcatcatgg tctttatgtc tctctactca     1320

gtgttgtata tgtcaagttt acttcctgcc aaaatgtttg caatcgcaac aataaacaaa     1380

gctgggtggg gcacatccgg aaggaaaacc attgttgtca acttcatagg actcatccca     1440

gtgtcagttt ggtttacaat tctcctgggt ggtgtgattt tcaccattta taaggaatct     1500

aaaaagccat tttctgaatc caaacagaca gttttaattg ttggaacatt gctctatgca     1560

tgctattggg tcatgctgtt gacactgtac gtggttctca tcaataagtg tggcaggcgg     1620

aagaaaggac agcagtatga catggtgctg gacgtatga                            1659


<210>  3
<211>  165
<212>  PRT
<213>  naked mole rat

<400>  3

Pro Gly Glu Thr Asp Glu Ser His Lys Glu Ser Ser Gln His Val Thr 
1               5                   10                  15      


Gln Leu Val Leu Ser Ser Lys Ser Val Cys Ile Met Gln Lys Trp Gly 
            20                  25                  30          


Gly Lys Arg Glu Val Met Tyr Thr Ala Phe Arg Ala Leu Gly Arg Ser 
        35                  40                  45              


Val Asp Tyr Val Gln Val Cys Asp Ser Asp Thr Met Leu Asp Pro Ala 
    50                  55                  60                  


Ser Ser Val Glu Met Val Lys Val Leu Glu Glu Asp Pro Met Val Gly 
65                  70                  75                  80  


Gly Val Gly Gly Asp Val Gln Ile Leu Asn Lys Tyr Asp Ser Trp Ile 
                85                  90                  95      


Ser Phe Leu Ser Ser Val Arg Tyr Trp Met Ala Phe Asn Ile Glu Arg 
            100                 105                 110         


Ala Cys Gln Ser Tyr Phe Gly Cys Val Gln Cys Ile Ser Gly Pro Leu 
        115                 120                 125             


Gly Met Tyr Arg Asn Ser Leu Leu His Glu Phe Val Glu Asp Trp Tyr 
    130                 135                 140                 


Ser Gln Glu Phe Met Gly Asn Gln Cys Ser Phe Gly Asp Asp Arg His 
145                 150                 155                 160 


Leu Thr Asn Arg Val 
                165 


