                         SEQUENCE LISTING

<110>  Moredun research Institute
       Matthews, Jacqueline
       Nisbet, Alasdair J
       Knox, David J
 
<120>  Sheep Nematode Vaccine

<130>  PG443191WO

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  162
<212>  PRT
<213>  Teladorsagia circumcincta

<400>  1

Met Phe Cys Arg Val Thr Val Ala Val Leu Leu Leu Ala Val Ser Ala 
1               5                   10                  15      


His Ala Gly Phe Phe Asp Asp Val Ser Gly Leu Ala Ser Asp Val Gly 
            20                  25                  30          


Asp Phe Phe Thr Lys Gln Phe Asn Asn Val Lys Asp Leu Phe Ala Asn 
        35                  40                  45              


Asn Gln Ser Glu Leu Glu Lys Asn Ile Gln Arg Val Lys Asp Leu Leu 
    50                  55                  60                  


Met Ala Ile Lys Glu Lys Ala Lys Met Leu Glu Pro Met Ala Asn Asp 
65                  70                  75                  80  


Ala Gln Lys Lys Thr Ile Ser Glu Val Asn Asn Tyr Met Gln Gln Val 
                85                  90                  95      


Asp Ala Phe Gly Ala Gln Val Lys Arg Asp Gly Glu Ala Lys Phe Glu 
            100                 105                 110         


Gln Asn Lys Ala Lys Trp Gln Asp Met Leu Asn Asn Ile Phe Glu Lys 
        115                 120                 125             


Gly Gly Leu Glu Asn Val Met Lys Leu Met Asn Leu Lys Ser Ala Thr 
    130                 135                 140                 


Gln Cys Thr Val Met Ala Ala Leu Ile Ala Pro Val Ile Leu Ala Phe 
145                 150                 155                 160 


Thr Arg 
        


<210>  2
<211>  115
<212>  PRT
<213>  Teladorsagia circumcincta

<400>  2

Met Pro Val Phe Ser Phe His Thr Asn Val Ser Ala Asp Lys Val Thr 
1               5                   10                  15      


Pro Asp Leu Leu Lys Gln Ile Ser Ser Val Val Ala Arg Ile Leu His 
            20                  25                  30          


Lys Pro Glu Ser Tyr Val Cys Val His Val Val Pro Asp Gln Gln Met 
        35                  40                  45              


Ile Phe Asp Gly Thr Asp Gly Pro Cys Gly Val Gly Val Leu Lys Ser 
    50                  55                  60                  


Ile Gly Gly Val Gly Gly Ser Lys Asn Asn Glu His Ala Lys Ala Leu 
65                  70                  75                  80  


Phe Ala Leu Ile Lys Asp His Leu Gly Ile Ala Gly Asn Arg Met Tyr 
                85                  90                  95      


Ile Glu Phe Ile Asp Ile Gly Ala Ala Asp Ile Ala Phe Asn Ser Arg 
            100                 105                 110         


Thr Phe Ala 
        115 


<210>  3
<211>  236
<212>  PRT
<213>  Teladorsagia circumcincta

<400>  3

Met Phe Thr Pro Ile Gly Ile Ala Val Leu Tyr Leu Ala Leu Val Thr 
1               5                   10                  15      


Pro His Ala Lys Ala Gly Phe Cys Cys Pro Ala Asp Leu Asp Gln Thr 
            20                  25                  30          


Asp Glu Ala Arg Lys Ile Leu Leu Asn Phe His Asn Glu Val Arg Arg 
        35                  40                  45              


Asp Val Ser Ser Ala Ser Pro Leu Leu Asn Leu Thr Gly Ala Val Leu 
    50                  55                  60                  


Met Arg Asn Val Leu Gly Pro Ala Lys Asn Met Tyr Lys Met Asp Trp 
65                  70                  75                  80  


Asp Cys Asn Leu Glu Lys Lys Ala Leu Glu Met Ile Ser Pro Cys Thr 
                85                  90                  95      


Val Pro Leu Pro Ile Asp Thr Ser Ile Pro Gln Asn Leu Ala Gln Trp 
            100                 105                 110         


Leu Leu Tyr Arg Lys Met Glu Glu Thr Glu Val Leu Glu Lys Ala Pro 
        115                 120                 125             


Trp Ser Trp Val Ile Ala Ser Leu Arg Asn Leu Lys Asn Asp Thr Glu 
    130                 135                 140                 


Ala Asp Leu Tyr Asn Trp Lys Ile Arg Thr Ile Ser Asn Ile Leu Asn 
145                 150                 155                 160 


Trp Arg Asn Thr Lys Val Gly Cys Ala His Lys Val Cys Gln Phe Pro 
                165                 170                 175     


Thr Gly Thr Asn Met Val Ile Ser Cys Ala Tyr Gly Gly Asp Lys Leu 
            180                 185                 190         


Glu Asn Asn Glu Val Val Trp Gln Lys Gly Pro Thr Cys Glu Cys Asn 
        195                 200                 205             


Ala Tyr Pro Asp Ser Tyr Cys Cys Asn Asn Leu Cys Asp Thr Lys Ala 
    210                 215                 220                 


Ala Ala Ala Leu Arg Glu Glu Pro Cys Lys Ser Asn 
225                 230                 235     


<210>  4
<211>  305
<212>  PRT
<213>  Teladorsagia circumcincta

<400>  4

Met Arg Leu Leu Asn Ser Met Gly Met Gln Glu Pro Pro Asn Val Asp 
1               5                   10                  15      


Ser Ile Asp Leu Ser Pro Ser Thr Ile Glu Glu Met Leu Glu Ser Leu 
            20                  25                  30          


Gly Glu Asn Asp Lys Leu Glu Gln Asp Gln Glu Glu Lys Thr Phe Ile 
        35                  40                  45              


Met Ala Val Asp Pro Ser Asp Gly Ile Asp Pro Asp Met Leu Val Ala 
    50                  55                  60                  


Arg Phe Pro Val Ser Ile Thr Thr Met Val Arg Lys Val Ser Arg Ala 
65                  70                  75                  80  


Tyr Leu His Val Tyr Leu His Val Ser Glu Pro Leu Pro Glu Pro Glu 
                85                  90                  95      


Ile Val Thr Val Val Val Arg Glu Arg Leu Leu Asn Gly Asp Val Gly 
            100                 105                 110         


Asp Ile Val Ala Thr Asn Pro Val Glu Ile Gln Arg Ser Gly Lys Ala 
        115                 120                 125             


Val Leu Pro Leu Arg Ala Ser Asp Val Glu Arg Trp Trp Lys Ser Glu 
    130                 135                 140                 


Pro Ile Leu Gly Leu Tyr Val Val Ala Met Leu Asn Gly Glu Asn Ile 
145                 150                 155                 160 


Ala Val His Pro Gln Gln Asp His His Ala Arg His Thr Met Phe Met 
                165                 170                 175     


Ser Val Ile Leu Ala Ser Asp Ala Lys Ser Arg Gly Lys Arg Ser Pro 
            180                 185                 190         


Ser Val Cys Met Pro Glu Asp Gln Glu Pro Gly Cys Cys Leu Tyr Asp 
        195                 200                 205             


Leu Ile Val Asp Phe Gln Gln Ile Gly Trp Lys Phe Ile Ile Ala Pro 
    210                 215                 220                 


His Lys Tyr Asn Ala Tyr Met Cys Arg Gly Asp Cys Ser Val Asn His 
225                 230                 235                 240 


Thr His Val Thr Arg Ser Gly His Thr Lys Val Ala Lys Thr Gly Ile 
                245                 250                 255     


Ile Thr Arg Gln Asp Ala Thr Gly Asn Gln Gly Met Cys Cys His Pro 
            260                 265                 270         


Ala Glu Tyr Asp Ala Val Arg Met Ile Tyr Met Asn Gly Asp Asn Gln 
        275                 280                 285             


Val Thr Met Ala Arg Val Pro Gly Met Ile Ala Arg Lys Cys Thr Cys 
    290                 295                 300                 


Ser 
305 


<210>  5
<211>  364
<212>  PRT
<213>  Teladorsagia circumcincta

<400>  5

Met Ser Leu Leu Phe Leu Leu Leu Ile Pro His Leu Phe Ala Ala Thr 
1               5                   10                  15      


Val Lys Gln Gln Tyr Ser Gly Gly Val Lys Pro Leu Thr Glu Leu Arg 
            20                  25                  30          


Thr Asp Leu Ile Asp Lys Lys Thr Lys Gly Ser Ile Glu Phe Ala Arg 
        35                  40                  45              


Leu Gly Gln His Ile Ser Pro Lys Asp Phe Gly Ala Trp Asn His Phe 
    50                  55                  60                  


Thr Ser Phe Ile Glu Arg His Asp Lys Val Tyr Arg Asn Glu Ser Glu 
65                  70                  75                  80  


Ala Leu Lys Arg Phe Gly Ile Phe Lys Arg Asn Leu Glu Ile Ile Arg 
                85                  90                  95      


Ser Ala Gln Glu Asn Asp Lys Gly Thr Ala Ile Tyr Gly Ile Asn Gln 
            100                 105                 110         


Phe Ala Asp Leu Ser Pro Glu Glu Phe Lys Lys Thr His Leu Pro His 
        115                 120                 125             


Thr Trp Lys Gln Pro Asp His Pro Asn Arg Ile Val Asp Leu Ala Ala 
    130                 135                 140                 


Glu Gly Val Asp Pro Lys Glu Pro Leu Pro Glu Ser Phe Asp Trp Arg 
145                 150                 155                 160 


Glu His Gly Ala Val Thr Lys Val Lys Thr Glu Gly His Cys Ala Ala 
                165                 170                 175     


Cys Trp Ala Phe Ser Val Thr Gly Asn Ile Glu Gly Gln Trp Phe Leu 
            180                 185                 190         


Ala Lys Lys Lys Leu Val Ser Leu Ser Ala Gln Gln Leu Leu Asp Cys 
        195                 200                 205             


Asp Val Val Asp Glu Gly Cys Asn Gly Gly Phe Pro Leu Asp Ala Tyr 
    210                 215                 220                 


Lys Glu Ile Val Arg Met Gly Gly Leu Glu Pro Glu Asp Lys Tyr Pro 
225                 230                 235                 240 


Tyr Glu Ala Lys Ala Glu Gln Cys Arg Leu Val Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Tyr Ile Asn Gly Ser Val Glu Leu Pro His Asp Glu Glu Lys Met 
            260                 265                 270         


Arg Ala Trp Leu Val Lys Lys Gly Pro Ile Ser Ile Gly Ile Thr Val 
        275                 280                 285             


Asp Asp Ile Gln Phe Tyr Lys Gly Gly Val Ser Arg Pro Thr Thr Cys 
    290                 295                 300                 


Arg Leu Ser Ser Met Ile His Gly Ala Leu Leu Val Gly Tyr Gly Val 
305                 310                 315                 320 


Glu Lys Asn Ile Pro Tyr Trp Ile Ile Lys Asn Ser Trp Gly Pro Asn 
                325                 330                 335     


Trp Gly Glu Asp Gly Tyr Tyr Arg Met Val Arg Gly Glu Asn Ala Cys 
            340                 345                 350         


Arg Ile Asn Arg Phe Pro Thr Ser Ala Val Val Leu 
        355                 360                 


<210>  6
<211>  339
<212>  PRT
<213>  Teladorsagia circumcincta

<400>  6

Met Leu Leu Tyr Ile Leu Ser Leu Val Leu Leu Ile Asp Ala Leu Pro 
1               5                   10                  15      


Pro Gly Tyr Pro Asp Gly Lys Glu His Gly Ser Arg Pro Thr Ile Arg 
            20                  25                  30          


Ser Leu Pro Asp Gly Ser Thr Glu Tyr Lys Leu Leu Ile Val Thr Asp 
        35                  40                  45              


Met Asp Lys Asp Ser Lys Ala Gly Glu Trp Thr Trp Arg Ala Val Thr 
    50                  55                  60                  


Arg Glu Gly Arg Leu Thr Leu Ser Pro Asp Met Ala His Val Ser Ile 
65                  70                  75                  80  


Ala Trp Asp Glu Asn Ser Glu Arg Asn Leu Thr Ser Ser Met Asn Ile 
                85                  90                  95      


Lys Gly Arg Ala Met Glu Leu Ser Asp Leu Ser Val Phe His Asn Arg 
            100                 105                 110         


Ile Leu Thr Pro Asp Asp Arg Thr Gly Leu Ile Ser Glu Ile Lys Asn 
        115                 120                 125             


Asn Lys Met Ile Pro Trp Val Phe Leu Asn Ser Gly Pro Gly Asn Thr 
    130                 135                 140                 


Thr Ser Pro Phe Lys Cys Glu Trp Met Thr Ile Lys Asp Asp Val Leu 
145                 150                 155                 160 


Tyr Val Gly Gly His Gly Asn Glu Phe Arg Asn Lys Gln Gly Glu Ile 
                165                 170                 175     


Val His Arg Asn Asn Leu Trp Ile Lys Thr Val Thr Pro Glu Gly Glu 
            180                 185                 190         


Val Thr Asn Val Asp Trp Thr Asp Val Phe Asn Asn Leu Arg Asn Ala 
        195                 200                 205             


Val Gly Ile Ser Glu Pro Gly Tyr Leu Thr His Glu Ala Val Gln Trp 
    210                 215                 220                 


Ser Glu Lys Gln Gly His Trp Tyr Phe Leu Pro Arg Lys Glu Ser Lys 
225                 230                 235                 240 


Thr Val Tyr Val Glu Glu Asp Asp Glu Lys Lys Gly Thr Asp Leu Leu 
                245                 250                 255     


Ile Ile Gly Asn Pro Asp Leu Asp Gln Phe Glu Thr Lys Arg Ile Gly 
            260                 265                 270         


Val Leu Arg Pro Glu Arg Gly Tyr Ser Ala Phe Asp Phe Ile Pro Gly 
        275                 280                 285             


Thr Asp Asp Lys Ile Ile Val Ala Leu Lys Ser Lys Glu Val Thr Asp 
    290                 295                 300                 


Glu Pro Thr Glu Thr Tyr Val Thr Val Phe Thr Ile Asp Gly Glu Ile 
305                 310                 315                 320 


Leu Leu Asp Asp Gln Lys Leu Asp Gly Asn Tyr Lys Phe Glu Gly Leu 
                325                 330                 335     


Tyr Phe Ile 
            


<210>  7
<211>  498
<212>  PRT
<213>  Teladorsagia circumcincta

<400>  7

Met Arg Leu Ala Val Leu Leu Leu Val Leu Val Val Ser Ala Gln Ala 
1               5                   10                  15      


Gly Leu Leu Asp Lys Val Lys Asp Phe Phe Lys Gly Gly Asn Phe Gly 
            20                  25                  30          


Glu Lys Thr Lys Thr Ala Thr Leu Ser Lys Phe Lys Lys Leu Phe Glu 
        35                  40                  45              


Lys Thr Gly Ile Leu Ser Leu Gly Asn Lys Leu Ala Glu Met Arg Ser 
    50                  55                  60                  


Lys Val Met Lys Lys Leu Glu Leu Ser Lys Ala Lys Lys Ala Glu Val 
65                  70                  75                  80  


Asp Arg Lys Leu Lys Glu Val Glu Glu Arg Met Asp Asn Thr Val Glu 
                85                  90                  95      


Asn Leu Lys Asp Thr Ile Phe Glu Ile Asn Ala Val Lys Asn Val Gly 
            100                 105                 110         


Glu Ser Leu Phe Gln Ser Asp Ile Leu Leu Thr Lys Arg Gln Val Glu 
        115                 120                 125             


Glu Val Met Asp Gly Val Glu Gly Gly Arg Pro Lys Arg Gln Ala Phe 
    130                 135                 140                 


Lys Asp Gln Asn Tyr Pro Asn Thr Thr Trp Gln Gln Gly Val Phe Tyr 
145                 150                 155                 160 


Arg Phe Asp Asp Ser Ala Asp Tyr Tyr Thr Arg Lys Val Phe Glu Met 
                165                 170                 175     


Gly Thr Lys Gln Trp Glu Glu Ala Thr Cys Ile Asp Phe Lys Glu Asp 
            180                 185                 190         


Lys Glu Lys Lys Ala Glu Asn Ser Ile Ile Leu Ile Lys Glu Asp Gly 
        195                 200                 205             


Cys Trp Ser Tyr Val Gly Gln Val Gly Gly Glu Gln Pro Leu Ser Leu 
    210                 215                 220                 


Gly Asp Gly Cys Glu Gln Val Gly Ile Ala Thr His Glu Leu Gly His 
225                 230                 235                 240 


Ala Leu Gly Leu Phe His Thr Met Ser Arg Tyr Asp Arg Asp Asp Phe 
                245                 250                 255     


Ile Thr Val Val Leu Glu Asn Val Val Glu Gly Phe Val Asp Gln Tyr 
            260                 265                 270         


Ile Lys Glu Thr Pro Gln Thr Thr Thr Asn Tyr Gly Phe Thr Tyr Asp 
        275                 280                 285             


Tyr Gly Ser Ile Met His Tyr Gly Ala Ser Ser Ala Ser His Asn Asn 
    290                 295                 300                 


Lys Pro Thr Met Val Ala Asn Asp Thr Arg Tyr Gln Glu Ser Met Gly 
305                 310                 315                 320 


Ser Gln Ile Ile Ser Phe Ile Asp Lys Ser Met Ile Asn Asp His Tyr 
                325                 330                 335     


Asn Cys Lys Ala Asp Cys Pro Lys Ala Thr Ser Ala Lys Cys Gln Asn 
            340                 345                 350         


Gly Gly Phe Pro His Pro Arg Lys Cys Ser Glu Cys Ile Cys Pro Ser 
        355                 360                 365             


Gly Tyr Gly Gly Ala Leu Cys Asp Gln Arg Pro Thr Gly Cys Gly Gln 
    370                 375                 380                 


Thr Leu Lys Ala Lys Glu Ser Lys Gln Phe Leu Ile Asp Lys Leu Gly 
385                 390                 395                 400 


Phe Pro Ser Gly Val Arg Asp Glu Phe Thr Phe Cys Asn His Trp Ile 
                405                 410                 415     


Glu Ala Pro Glu Gly Lys Lys Ile Glu Leu Lys Ile Asn Ser Ile Ser 
            420                 425                 430         


His Gly Tyr Ala His Asp Gly Cys Ile Leu Gly Gly Val Glu Ile Lys 
        435                 440                 445             


Thr Ser Glu Asp Gln Thr Arg Thr Gly Phe Arg Phe Cys Ser Pro Asn 
    450                 455                 460                 


Asp Arg Asn Thr Val Leu Val Ser Ala Ser Asn Arg Val Pro Ile Ile 
465                 470                 475                 480 


Thr Phe Asn Arg Ser Gly Gln Gln Gln Ile Ile Leu Glu Tyr Lys Val 
                485                 490                 495     


Val Ser 
        


<210>  8
<211>  160
<212>  PRT
<213>  Teladorsagia circumcincta

<400>  8

Met Leu Arg Ser Ile Leu Leu Ile Leu Val Ser Ala Ser Val Tyr Val 
1               5                   10                  15      


Ser Val Gln Gly Gln Gly Asn Gly Asp Met Lys Lys Val Glu Leu Tyr 
            20                  25                  30          


Met Gly Tyr Ala Lys Lys Asp Met Glu Lys Val Arg Glu Phe Leu Lys 
        35                  40                  45              


Leu Lys Asp Glu Arg Leu Thr Lys Leu Leu Ser Asp Leu Phe Arg Tyr 
    50                  55                  60                  


Leu Asp Lys Thr Thr Phe Glu Trp Met Lys Asp Glu Ala Thr Leu Glu 
65                  70                  75                  80  


Gln Phe Ile Gln Thr Arg Gly Lys Phe Ser Ser Ala Leu Val His Pro 
                85                  90                  95      


Asp Val Gln Lys Arg Tyr Lys Asp Asn Arg Lys Leu Trp Ala Phe Arg 
            100                 105                 110         


Tyr Ala Arg Leu Met Asn Cys Ile Gly Gly Ser Asp Met Gly Arg Ala 
        115                 120                 125             


Thr Ala Tyr Leu Pro Gly Val Ser Val Gln Glu Lys Glu Glu Thr Leu 
    130                 135                 140                 


Arg Tyr Ser Leu Lys Leu Glu Arg Thr Cys Ala Tyr Thr Tyr Phe Arg 
145                 150                 155                 160 


