                         SEQUENCE LISTING

<110>  University of North Carolina at Chapel Hill
       Dana-Farber Cancer Institute, Inc.
       Sharpless, Norman
       Lui, Wenjin
       Bear, James
       Monahan, Kimberly
       Wong, Kwok-kin
 
<120>  LKB1/STK11 DELETION IN MELANOMA AND RELATED METHODS

<130>  421/298 PCT

<150>  61/595,512
<151>  2012-02-06

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  3286
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1116)..(2417)

<400>  1
gcgtgtcggg cgcggaaggg ggaggcggcc cggggcgccc gcgagtgagg cgcggggcgg     60

cgaagggagc gcgggtggcg gcacttgctg ccgcggcctt ggatgggctg ggcccccctc    120

gccgctccgc ctcctccaca cgcgcggcgg ccgcggcgag ggggacgcgc cgcccggggc    180

ccggcacctt cgggaacccc ccggcccgga gcctgcggcc tgcgccgcct cggccgccgg    240

gagccccgtg gagcccccgc cgccgcgccg ccccgcggac cggacgctga gggcactcgg    300

ggcggggcgc gcgctcgggc agacgtttgc ggggaggggg gcgcctgccg ggccccggcg    360

accaccttgg gggtcgcggg ccggctcggg gggcgcccag tgcgggccct cgcgggcgcc    420

gggcagcgac cagccctgag cggagctgtt ggccgcggcg ggaggcctcc cggacgcccc    480

cagccccccg aacgctcgcc cgggccggcg ggagtcggcg ccccccggga ggtccgctcg    540

gtcgtccgcg gcggagcgtt tgctcctggg acaggcggtg ggaccggggc gtcgccggag    600

acgcccccag cgaagttggg ctctccaggt gtgggggtcc cggggggtag cgacgtcgcg    660

gacccggcct gtgggatggg cggcccggag aagactgcgc tcggccgtgt tcatacttgt    720

ccgtgggcct gaggtccccg gaggatgacc tagcactgaa aagccccggc cggcctcccc    780

agggtccccg aggacgaagt tgaccctgac cgggccgtct cccagttctg aggcccgggt    840

cccactggaa ctcgcgtctg agccgccgtc ccggaccccc ggtgcccgcc ggtccgcaga    900

ccctgcaccg ggcttggact cgcagccggg actgacgtgt agaacaatcg tttctgttgg    960

aagaagggtt tttcccttcc ttttggggtt tttgttgcct tttttttttc ttttttcttt   1020

gtaaaatttt ggagaaggga agtcggaaca caaggaagga ccgctcaccc gcggactcag   1080

ggctggcggc gggactccag gaccctgggt ccagc atg gag gtg gtg gac ccg      1133
                                       Met Glu Val Val Asp Pro          
                                       1               5                

cag cag ctg ggc atg ttc acg gag ggc gag ctg atg tcg gtg ggt atg     1181
Gln Gln Leu Gly Met Phe Thr Glu Gly Glu Leu Met Ser Val Gly Met         
            10                  15                  20                  

gac acg ttc atc cac cgc atc gac tcc acc gag gtc atc tac cag ccg     1229
Asp Thr Phe Ile His Arg Ile Asp Ser Thr Glu Val Ile Tyr Gln Pro         
        25                  30                  35                      

cgc cgc aag cgg gcc aag ctc atc ggc aag tac ctg atg ggg gac ctg     1277
Arg Arg Lys Arg Ala Lys Leu Ile Gly Lys Tyr Leu Met Gly Asp Leu         
    40                  45                  50                          

ctg ggg gaa ggc tct tac ggc aag gtg aag gag gtg ctg gac tcg gag     1325
Leu Gly Glu Gly Ser Tyr Gly Lys Val Lys Glu Val Leu Asp Ser Glu         
55                  60                  65                  70          

acg ctg tgc agg agg gcc gtc aag atc ctc aag aag aag aag ttg cga     1373
Thr Leu Cys Arg Arg Ala Val Lys Ile Leu Lys Lys Lys Lys Leu Arg         
                75                  80                  85              

agg atc ccc aac ggg gag gcc aac gtg aag aag gaa att caa cta ctg     1421
Arg Ile Pro Asn Gly Glu Ala Asn Val Lys Lys Glu Ile Gln Leu Leu         
            90                  95                  100                 

agg agg tta cgg cac aaa aat gtc atc cag ctg gtg gat gtg tta tac     1469
Arg Arg Leu Arg His Lys Asn Val Ile Gln Leu Val Asp Val Leu Tyr         
        105                 110                 115                     

aac gaa gag aag cag aaa atg tat atg gtg atg gag tac tgc gtg tgt     1517
Asn Glu Glu Lys Gln Lys Met Tyr Met Val Met Glu Tyr Cys Val Cys         
    120                 125                 130                         

ggc atg cag gaa atg ctg gac agc gtg ccg gag aag cgt ttc cca gtg     1565
Gly Met Gln Glu Met Leu Asp Ser Val Pro Glu Lys Arg Phe Pro Val         
135                 140                 145                 150         

tgc cag gcc cac ggg tac ttc tgt cag ctg att gac ggc ctg gag tac     1613
Cys Gln Ala His Gly Tyr Phe Cys Gln Leu Ile Asp Gly Leu Glu Tyr         
                155                 160                 165             

ctg cat agc cag ggc att gtg cac aag gac atc aag ccg ggg aac ctg     1661
Leu His Ser Gln Gly Ile Val His Lys Asp Ile Lys Pro Gly Asn Leu         
            170                 175                 180                 

ctg ctc acc acc ggt ggc acc ctc aaa atc tcc gac ctg ggc gtg gcc     1709
Leu Leu Thr Thr Gly Gly Thr Leu Lys Ile Ser Asp Leu Gly Val Ala         
        185                 190                 195                     

gag gca ctg cac ccg ttc gcg gcg gac gac acc tgc cgg acc agc cag     1757
Glu Ala Leu His Pro Phe Ala Ala Asp Asp Thr Cys Arg Thr Ser Gln         
    200                 205                 210                         

ggc tcc ccg gct ttc cag ccg ccc gag att gcc aac ggc ctg gac acc     1805
Gly Ser Pro Ala Phe Gln Pro Pro Glu Ile Ala Asn Gly Leu Asp Thr         
215                 220                 225                 230         

ttc tcc ggc ttc aag gtg gac atc tgg tcg gct ggg gtc acc ctc tac     1853
Phe Ser Gly Phe Lys Val Asp Ile Trp Ser Ala Gly Val Thr Leu Tyr         
                235                 240                 245             

aac atc acc acg ggt ctg tac ccc ttc gaa ggg gac aac atc tac aag     1901
Asn Ile Thr Thr Gly Leu Tyr Pro Phe Glu Gly Asp Asn Ile Tyr Lys         
            250                 255                 260                 

ttg ttt gag aac atc ggg aag ggg agc tac gcc atc ccg ggc gac tgt     1949
Leu Phe Glu Asn Ile Gly Lys Gly Ser Tyr Ala Ile Pro Gly Asp Cys         
        265                 270                 275                     

ggc ccc ccg ctc tct gac ctg ctg aaa ggg atg ctt gag tac gaa ccg     1997
Gly Pro Pro Leu Ser Asp Leu Leu Lys Gly Met Leu Glu Tyr Glu Pro         
    280                 285                 290                         

gcc aag agg ttc tcc atc cgg cag atc cgg cag cac agc tgg ttc cgg     2045
Ala Lys Arg Phe Ser Ile Arg Gln Ile Arg Gln His Ser Trp Phe Arg         
295                 300                 305                 310         

aag aaa cat cct ccg gct gaa gca cca gtg ccc atc cca ccg agc cca     2093
Lys Lys His Pro Pro Ala Glu Ala Pro Val Pro Ile Pro Pro Ser Pro         
                315                 320                 325             

gac acc aag gac cgg tgg cgc agc atg act gtg gtg ccg tac ttg gag     2141
Asp Thr Lys Asp Arg Trp Arg Ser Met Thr Val Val Pro Tyr Leu Glu         
            330                 335                 340                 

gac ctg cac ggc gcg gac gag gac gag gac ctc ttc gac atc gag gat     2189
Asp Leu His Gly Ala Asp Glu Asp Glu Asp Leu Phe Asp Ile Glu Asp         
        345                 350                 355                     

gac atc atc tac act cag gac ttc acg gtg ccc gga cag gtc cca gaa     2237
Asp Ile Ile Tyr Thr Gln Asp Phe Thr Val Pro Gly Gln Val Pro Glu         
    360                 365                 370                         

gag gag gcc agt cac aat gga cag cgc cgg ggc ctc ccc aag gcc gtg     2285
Glu Glu Ala Ser His Asn Gly Gln Arg Arg Gly Leu Pro Lys Ala Val         
375                 380                 385                 390         

tgt atg aac ggc aca gag gcg gcg cag ctg agc acc aaa tcc agg gcg     2333
Cys Met Asn Gly Thr Glu Ala Ala Gln Leu Ser Thr Lys Ser Arg Ala         
                395                 400                 405             

gag ggc cgg gcc ccc aac cct gcc cgc aag gcc tgc tcc gcc agc agc     2381
Glu Gly Arg Ala Pro Asn Pro Ala Arg Lys Ala Cys Ser Ala Ser Ser         
            410                 415                 420                 

aag atc cgc cgg ctg tcg gcc tgc aag cag cag tga ggctggccgc          2427
Lys Ile Arg Arg Leu Ser Ala Cys Lys Gln Gln                             
        425                 430                                         

ctgcagcccg tgtccaggag ccccgccagg tgcccgcgcc aggccctcag tcttcctgcc   2487

ggttccgccc gccctcccgg agaggtggcc gccatgcttc tgtgccgacc acgccccagg   2547

acctccggag cgccctgcag ggccgggcag ggggacagca gggaccgggc gcagccctcc   2607

cccctcggcc gcccggcagt gcacgcggct tgttgacttc gcagccccgg gcggagcctt   2667

cccgggcggg cgtgggagga gggaggcggc ctccatgcac tttatgtgga gactactggc   2727

cccgcccgtg gcctcgtgct ccgcagggcg cccagcgccg tccggcggcc ccgccgcaga   2787

ccagctggcg ggtgtggaga ccaggctcct gaccccgcca tgcatgcagc gccacctgga   2847

agccgcgcgg ccgctttggt tttttgtttg gttggttcca ttttcttttt ttcttttttt   2907

ttttaagaaa aaataaaagg tggatttgag ctgtggctgt gaggggtgtt tgggagctgc   2967

tgggtggcag gggggctgtg gggtcgggct cacgtcgcgg ccgcctttgc gctctcgggt   3027

caccctgctt tggcggcccg gccggagggc aggaccctca cctctccccc aaggccactg   3087

cgctcttggg accccagaga aaacccggag caagcaggag tgtgcggtca atatttatat   3147

catccagaaa agaaaaacac gagaaacgcc atcgcgggat ggtgcagacg cggcggggac   3207

tcggagggtg ccgtgcgggc gaggccgccc aaatttggca ataaataaag cttgggaagc   3267

ttggacctga aaaaaaaaa                                                3286


<210>  2
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Val Val Asp Pro Gln Gln Leu Gly Met Phe Thr Glu Gly Glu 
1               5                   10                  15      


Leu Met Ser Val Gly Met Asp Thr Phe Ile His Arg Ile Asp Ser Thr 
            20                  25                  30          


Glu Val Ile Tyr Gln Pro Arg Arg Lys Arg Ala Lys Leu Ile Gly Lys 
        35                  40                  45              


Tyr Leu Met Gly Asp Leu Leu Gly Glu Gly Ser Tyr Gly Lys Val Lys 
    50                  55                  60                  


Glu Val Leu Asp Ser Glu Thr Leu Cys Arg Arg Ala Val Lys Ile Leu 
65                  70                  75                  80  


Lys Lys Lys Lys Leu Arg Arg Ile Pro Asn Gly Glu Ala Asn Val Lys 
                85                  90                  95      


Lys Glu Ile Gln Leu Leu Arg Arg Leu Arg His Lys Asn Val Ile Gln 
            100                 105                 110         


Leu Val Asp Val Leu Tyr Asn Glu Glu Lys Gln Lys Met Tyr Met Val 
        115                 120                 125             


Met Glu Tyr Cys Val Cys Gly Met Gln Glu Met Leu Asp Ser Val Pro 
    130                 135                 140                 


Glu Lys Arg Phe Pro Val Cys Gln Ala His Gly Tyr Phe Cys Gln Leu 
145                 150                 155                 160 


Ile Asp Gly Leu Glu Tyr Leu His Ser Gln Gly Ile Val His Lys Asp 
                165                 170                 175     


Ile Lys Pro Gly Asn Leu Leu Leu Thr Thr Gly Gly Thr Leu Lys Ile 
            180                 185                 190         


Ser Asp Leu Gly Val Ala Glu Ala Leu His Pro Phe Ala Ala Asp Asp 
        195                 200                 205             


Thr Cys Arg Thr Ser Gln Gly Ser Pro Ala Phe Gln Pro Pro Glu Ile 
    210                 215                 220                 


Ala Asn Gly Leu Asp Thr Phe Ser Gly Phe Lys Val Asp Ile Trp Ser 
225                 230                 235                 240 


Ala Gly Val Thr Leu Tyr Asn Ile Thr Thr Gly Leu Tyr Pro Phe Glu 
                245                 250                 255     


Gly Asp Asn Ile Tyr Lys Leu Phe Glu Asn Ile Gly Lys Gly Ser Tyr 
            260                 265                 270         


Ala Ile Pro Gly Asp Cys Gly Pro Pro Leu Ser Asp Leu Leu Lys Gly 
        275                 280                 285             


Met Leu Glu Tyr Glu Pro Ala Lys Arg Phe Ser Ile Arg Gln Ile Arg 
    290                 295                 300                 


Gln His Ser Trp Phe Arg Lys Lys His Pro Pro Ala Glu Ala Pro Val 
305                 310                 315                 320 


Pro Ile Pro Pro Ser Pro Asp Thr Lys Asp Arg Trp Arg Ser Met Thr 
                325                 330                 335     


Val Val Pro Tyr Leu Glu Asp Leu His Gly Ala Asp Glu Asp Glu Asp 
            340                 345                 350         


Leu Phe Asp Ile Glu Asp Asp Ile Ile Tyr Thr Gln Asp Phe Thr Val 
        355                 360                 365             


Pro Gly Gln Val Pro Glu Glu Glu Ala Ser His Asn Gly Gln Arg Arg 
    370                 375                 380                 


Gly Leu Pro Lys Ala Val Cys Met Asn Gly Thr Glu Ala Ala Gln Leu 
385                 390                 395                 400 


Ser Thr Lys Ser Arg Ala Glu Gly Arg Ala Pro Asn Pro Ala Arg Lys 
                405                 410                 415     


Ala Cys Ser Ala Ser Ser Lys Ile Arg Arg Leu Ser Ala Cys Lys Gln 
            420                 425                 430         


Gln 
    


<210>  3
<211>  4685
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (222)..(1853)

<400>  3
ggaggaggtg gagagtgagg ccgaggcgtg gggagcccgg gaactccctc ctcctgaagt     60

aacgcgtccc gggccggctc tgccgtcgtt gctgccgccg ggcgccccgg gacgaggagg    120

tggaggaggg agagggcccg cgggcctcgc ctccgccctc cgccacctcg agctgcggta    180

gcagcgactc atgagagcgc ggccggagga cagatttgat a atg ggc tgc att aaa    236
                                              Met Gly Cys Ile Lys       
                                              1               5         

agt aaa gaa aac aaa agt cca gcc att aaa tac aga cct gaa aat act      284
Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr Arg Pro Glu Asn Thr         
                10                  15                  20              

cca gag cct gtc agt aca agt gtg agc cat tat gga gca gaa ccc act      332
Pro Glu Pro Val Ser Thr Ser Val Ser His Tyr Gly Ala Glu Pro Thr         
            25                  30                  35                  

aca gtg tca cca tgt ccg tca tct tca gca aag gga aca gca gtt aat      380
Thr Val Ser Pro Cys Pro Ser Ser Ser Ala Lys Gly Thr Ala Val Asn         
        40                  45                  50                      

ttc agc agt ctt tcc atg aca cca ttt gga gga tcc tca ggg gta acg      428
Phe Ser Ser Leu Ser Met Thr Pro Phe Gly Gly Ser Ser Gly Val Thr         
    55                  60                  65                          

cct ttt gga ggt gca tct tcc tca ttt tca gtg gtg cca agt tca tat      476
Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val Val Pro Ser Ser Tyr         
70                  75                  80                  85          

cct gct ggt tta aca ggt ggt gtt act ata ttt gtg gcc tta tat gat      524
Pro Ala Gly Leu Thr Gly Gly Val Thr Ile Phe Val Ala Leu Tyr Asp         
                90                  95                  100             

tat gaa gct aga act aca gaa gac ctt tca ttt aag aag ggt gaa aga      572
Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe Lys Lys Gly Glu Arg         
            105                 110                 115                 

ttt caa ata att aac aat acg gaa gga gat tgg tgg gaa gca aga tca      620
Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp Trp Glu Ala Arg Ser         
        120                 125                 130                     

atc gct aca gga aag aat ggt tat atc ccg agc aat tat gta gcg cct      668
Ile Ala Thr Gly Lys Asn Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro         
    135                 140                 145                         

gca gat tcc att cag gca gaa gaa tgg tat ttt ggc aaa atg ggg aga      716
Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Met Gly Arg         
150                 155                 160                 165         

aaa gat gct gaa aga tta ctt ttg aat cct gga aat caa cga ggt att      764
Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly Asn Gln Arg Gly Ile         
                170                 175                 180             

ttc tta gta aga gag agt gaa aca act aaa ggt gct tat tcc ctt tct      812
Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser         
            185                 190                 195                 

att cgt gat tgg gat gag ata agg ggt gac aat gtg aaa cac tac aaa      860
Ile Arg Asp Trp Asp Glu Ile Arg Gly Asp Asn Val Lys His Tyr Lys         
        200                 205                 210                     

att agg aaa ctt gac aat ggt gga tac tat atc aca acc aga gca caa      908
Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln         
    215                 220                 225                         

ttt gat act ctg cag aaa ttg gtg aaa cac tac aca gaa cat gct gat      956
Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr Thr Glu His Ala Asp         
230                 235                 240                 245         

ggt tta tgc cac aag ttg aca act gtg tgt cca act gtg aaa cct cag     1004
Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro Thr Val Lys Pro Gln         
                250                 255                 260             

act caa ggt cta gca aaa gat gct tgg gaa atc cct cga gaa tct ttg     1052
Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu         
            265                 270                 275                 

cga cta gag gtt aaa cta gga caa gga tgt ttc ggc gaa gtg tgg atg     1100
Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met         
        280                 285                 290                     

gga aca tgg aat gga acc acg aaa gta gca atc aaa aca cta aaa cca     1148
Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile Lys Thr Leu Lys Pro         
    295                 300                 305                         

ggt aca atg atg cca gaa gct ttc ctt caa gaa gct cag ata atg aaa     1196
Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu Ala Gln Ile Met Lys         
310                 315                 320                 325         

aaa tta aga cat gat aaa ctt gtt cca cta tat gct gtt gtt tct gaa     1244
Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr Ala Val Val Ser Glu         
                330                 335                 340             

gaa cca att tac att gtc act gaa ttt atg tca aaa gga agc tta tta     1292
Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser Lys Gly Ser Leu Leu         
            345                 350                 355                 

gat ttc ctt aag gaa gga gat gga aag tat ttg aag ctt cca cag ctg     1340
Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu Lys Leu Pro Gln Leu         
        360                 365                 370                     

gtt gat atg gct gct cag att gct gat ggt atg gca tat att gaa aga     1388
Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met Ala Tyr Ile Glu Arg         
    375                 380                 385                         

atg aac tat att cac cga gat ctt cgg gct gct aat att ctt gta gga     1436
Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly         
390                 395                 400                 405         

gaa aat ctt gtg tgc aaa ata gca gac ttt ggt tta gca agg tta att     1484
Glu Asn Leu Val Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile         
                410                 415                 420             

gaa gac aat gaa tac aca gca aga caa ggt gca aaa ttt cca atc aaa     1532
Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys         
            425                 430                 435                 

tgg aca gct cct gaa gct gca ctg tat ggt cgg ttt aca ata aag tct     1580
Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser         
        440                 445                 450                     

gat gtc tgg tca ttt gga att ctg caa aca gaa cta gta aca aag ggc     1628
Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu Leu Val Thr Lys Gly         
    455                 460                 465                         

cga gtg cca tat cca ggt atg gtg aac cgt gaa gta cta gaa caa gtg     1676
Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Glu Gln Val         
470                 475                 480                 485         

gag cga gga tac agg atg ccg tgc cct cag ggc tgt cca gaa tcc ctc     1724
Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly Cys Pro Glu Ser Leu         
                490                 495                 500             

cat gaa ttg atg aat ctg tgt tgg aag aag gac cct gat gaa aga cca     1772
His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp Pro Asp Glu Arg Pro         
            505                 510                 515                 

aca ttt gaa tat att cag tcc ttc ttg gaa gac tac ttc act gct aca     1820
Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr         
        520                 525                 530                     

gag cca cag tac cag cca gga gaa aat tta taa ttcaagtagc ctattttata   1873
Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu                                 
    535                 540                                             

tgcacaaatc tgccaaaata taaagaactt gtgtagattt tctacaggaa tcaaaagaag   1933

aaaatcttct ttactctgca tgtttttaat ggtaaactgg aatcccagat atggttgcac   1993

aaaaccactt ttttttcccc aagtattaaa ctctaatgta ccaatgatga atttatcagc   2053

gtatttcagg gtccaaacaa aatagagcta agatactgat gacagtgtgg gtgacagcat   2113

ggtaatgaag gacagtgagg ctcctgctta tttataaatc atttcctttc tttttttccc   2173

caaagtcaga attgctcaaa gaaaattatt tattgttaca gataaaactt gagagataaa   2233

aagctatacc ataataaaat ctaaaattaa ggaatatcat gggaccaaat aattccattc   2293

cagtttttta aagtttcttg catttattat tctcaaaagt tttttctaag ttaaacagtc   2353

agtatgcaat cttaatatat gctttctttt gcatggacat gggccaggtt tttcaaaagg   2413

aatataaaca ggatctcaaa cttgattaaa tgttagacca cagaagtgga atttgaaagt   2473

ataatgcagt acattaatat tcatgttcat ggaactgaaa gaataagaac tttttcactt   2533

cagtcctttt ctgaagagtt tgacttagaa taatgaaggt aactagaaag tgagttaatc   2593

ttgtatgagg ttgcattgat tttttaaggc aatatataat tgaaactact gtccaatcaa   2653

aggggaaatg ttttgatctt tagatagcat gcaaagtaag acccagcatt ttaaaagccc   2713

tttttaaaaa ctagacttcg tactgtgagt attgcttata tgtccttatg gggatgggtg   2773

ccacaaatag aaaatatgac cagatcaggg acttgaatgc acttttgctc atggtgaata   2833

tagatgaaca gagaggaaaa tgtatttaaa agaaatacga gaaaagaaag tgaaagtttt   2893

acaagttaga gggatggaag gtaatgttta atgttgatgt catggagtga cagaatggct   2953

ttgctggcac tcagagctcc tcacttagct atattctgag actttgaaga gttataaagt   3013

ataactataa aactaatttt tcttacacac taaatgggta tttgttcaaa ataatgaagt   3073

tatggcttca cattcattgc agtgggatat ggtttttatg taaaacattt ttagaactcc   3133

agttttcaaa tcatgtttga atctacattc actttttttt gttttctttt ttgagacgga   3193

gtctcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac tgcaagctct   3253

gcctcccagg ttcacaccat tctcctgcct cagcctcccg agtagctggg actacaggtg   3313

cccaccacca cgcctggcta gttttttgta tttttagtag agacgcagtt tcaccgtgtt   3373

agccaggatg gtctcgatct cctgaccttg tgatctgccc gcctcggcct cccaaagtgc   3433

tgggattaca ggcgtgagcc accgcgccca gcctacattc acttctaaag tctatgtaat   3493

ggtggtcatt ttttcccttt tagaatacat taaatggttg atttggggag gaaaacttat   3553

tctgaatatt aacggtggtg aaaaggggac agtttttacc ctaaagtgca aaagtgaaac   3613

atacaaaata agactaattt ttaagagtaa ctcagtaatt tcaaaataca gatttgaata   3673

gcagcattag tggtttgagt gtctagcaaa ggaaaaattg atgaataaaa tgaaggtctg   3733

gtgtatatgt tttaaaatac tctcatatag tcacacttta aattaagcct tatattaggc   3793

ccctctattt tcaggatata attcttaact atcattattt acctgatttt aatcatcaga   3853

ttcgaaattc tgtgccatgg catatatgtt caaattcaaa ccatttttaa aatgtgaaga   3913

tggacttcat gcaagttggc agtggttctg gtactaaaaa ttgtggttgt tttttctgtt   3973

tacgtaacct gcttagtatt gacactctct accaagaggg tcttcctaag aagagtgctg   4033

tcattatttc ctcttatcaa caacttgtga catgagattt tttaagggct ttatgtgaac   4093

tatgatattg taatttttct aagcatattc aaaagggtga caaaattacg tttatgtact   4153

aaatctaatc aggaaagtaa ggcaggaaaa gttgatggta ttcattaggt tttaactgaa   4213

tggagcagtt ccttatataa taacaattgt atagtaggga taaaacacta acttaatgtg   4273

tattcatttt aaattgttct gtatttttaa attgccaaga aaaacaactt tgtaaatttg   4333

gagatatttt ccaacagctt ttcgtcttca gtgtcttaat gtggaagtta acccttacca   4393

aaaaaggaag ttggcaaaaa cagccttcta gcacactttt ttaaatgaat aatggtagcc   4453

taaacttaat atttttataa agtattgtaa tattgttttg tggataattg aaataaaaag   4513

ttctcattga atgcacctat taatcgtttt agttgctatt catattctca ttcgtttttt   4573

aaaaactgat atattctgaa tttattcttc cattgagaaa aaaatgttca gttacttgta   4633

actactgagc agaatttaat caatccttta ttaaattcag aacattattg aa           4685


<210>  4
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Arg Pro Glu Asn Thr Pro Glu Pro Val Ser Thr Ser Val Ser His Tyr 
            20                  25                  30          


Gly Ala Glu Pro Thr Thr Val Ser Pro Cys Pro Ser Ser Ser Ala Lys 
        35                  40                  45              


Gly Thr Ala Val Asn Phe Ser Ser Leu Ser Met Thr Pro Phe Gly Gly 
    50                  55                  60                  


Ser Ser Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val 
65                  70                  75                  80  


Val Pro Ser Ser Tyr Pro Ala Gly Leu Thr Gly Gly Val Thr Ile Phe 
                85                  90                  95      


Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe 
            100                 105                 110         


Lys Lys Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp 
        115                 120                 125             


Trp Glu Ala Arg Ser Ile Ala Thr Gly Lys Asn Gly Tyr Ile Pro Ser 
    130                 135                 140                 


Asn Tyr Val Ala Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe 
145                 150                 155                 160 


Gly Lys Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly 
                165                 170                 175     


Asn Gln Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly 
            180                 185                 190         


Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Glu Ile Arg Gly Asp Asn 
        195                 200                 205             


Val Lys His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile 
    210                 215                 220                 


Thr Thr Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr 
225                 230                 235                 240 


Thr Glu His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro 
                245                 250                 255     


Thr Val Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile 
            260                 265                 270         


Pro Arg Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe 
        275                 280                 285             


Gly Glu Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile 
    290                 295                 300                 


Lys Thr Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu 
305                 310                 315                 320 


Ala Gln Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr 
                325                 330                 335     


Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser 
            340                 345                 350         


Lys Gly Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu 
        355                 360                 365             


Lys Leu Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met 
    370                 375                 380                 


Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
385                 390                 395                 400 


Asn Ile Leu Val Gly Glu Asn Leu Val Cys Lys Ile Ala Asp Phe Gly 
                405                 410                 415     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala 
            420                 425                 430         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg 
        435                 440                 445             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu 
    450                 455                 460                 


Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu 
465                 470                 475                 480 


Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly 
                485                 490                 495     


Cys Pro Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp 
            500                 505                 510         


Pro Asp Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp 
        515                 520                 525             


Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540             


<210>  5
<211>  2194
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (111)..(353)

<400>  5
gggtctcgcc ggctcgccgc gctccccacc ttgcctgcgc ccgcccggag ccagcggttc     60

tccaagcacc cagcatcctg ctagacgcgc cgcgcaccga cggaggggac atg ggc       116
                                                       Met Gly          
                                                       1                

aga gca atg gtg gcc agg ctc ggg ctg ggg ctg ctg ctg ctg gca ctg      164
Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu Ala Leu         
        5                   10                  15                      

ctc cta ccc acg cag att tat tcc agt gaa aca aca act gga act tca      212
Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly Thr Ser         
    20                  25                  30                          

agt aac tcc tcc cag agt act tcc aac tct ggg ttg gcc cca aat cca      260
Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro Asn Pro         
35                  40                  45                  50          

act aat gcc acc acc aag gcg gct ggt ggt gcc ctg cag tca aca gcc      308
Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser Thr Ala         
                55                  60                  65              

agt ctc ttc gtg gtc tca ctc tct ctt ctg cat ctc tac tct taa          353
Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser                 
            70                  75                  80                  

gagactcagg ccaagaaacg tcttctaaat ttccccatct tctaaaccca atccaaatgg    413

cgtctggaag tccaatgtgg caaggaaaaa caggtcttca tcgaatctac taattccaca    473

ccttttattg acacagaaaa tgttgagaat cccaaatttg attgatttga agaacatgtg    533

agaggtttga ctagatgatg gatgccaata ttaaatctgc tggagtttca tgtacaagat    593

gaaggagagg caacatccaa aatagttaag acatgatttc cttgaatgtg gcttgagaaa    653

tatggacact taatactacc ttgaaaataa gaatagaaat aaaggatggg attgtggaat    713

ggagattcag ttttcatttg gttcattaat tctataaggc cataaaacag gtaatataaa    773

aagcttccat gattctattt atatgtacat gagaaggaac ttccaggtgt tactgtaatt    833

cctcaacgta ttgtttcgac agcactaatt taatgccgat atactctaga tgaagtttta    893

cattgttgag ctattgctgt tctcttggga actgaactca ctttcctcct gaggctttgg    953

atttgacatt gcatttgacc ttttatgtag taattgacat gtgccagggc aatgatgaat   1013

gagaatctac ccccagatcc aagcatcctg agcaactctt gattatccat attgagtcaa   1073

atggtaggca tttcctatca cctgtttcca ttcaacaaga gcactacatt catttagcta   1133

aacggattcc aaagagtaga attgcattga ccacgactaa tttcaaaatg ctttttatta   1193

ttattatttt ttagacagtc tcactttgtc gcccaggccg gagtgcagtg gtgcgatctc   1253

agatcagtgt accatttgcc tcccgggctc aagcgattct cctgcctcag cctcccaagt   1313

agctgggatt acaggcacct gccaccatgc ccggctaatt tttgtaattt tagtagagac   1373

agggtttcac catgttgccc aggctggttt cgaactcctg acctcaggtg atccacccgc   1433

ctcggcctcc caaagtgctg ggattacagg cttgagcccc cgcgcccagc catcaaaatg   1493

ctttttattt ctgcatatgt tgaatacttt ttacaattta aaaaaatgat ctgttttgaa   1553

ggcaaaattg caaatcttga aattaagaag gcaaaaatgt aaaggagtca aaactataaa   1613

tcaagtattt gggaagtgaa gactggaagc taatttgcat taaattcaca aacttttata   1673

ctctttctgt atatacattt tttttcttta aaaaacaact atggatcaga atagccacat   1733

ttagaacact ttttgttatc agtcaatatt tttagatagt tagaacctgg tcctaagcct   1793

aaaagtgggc ttgattctgc agtaaatctt ttacaactgc ctcgacacac ataaaccttt   1853

ttaaaaatag acactccccg aagtcttttg ttcgcatggt cacacactga tgcttagatg   1913

ttccagtaat ctaatatggc cacagtagtc ttgatgacca aagtcctttt tttccatctt   1973

tagaaaacta catgggaaca aacagatcga acagttttga agctactgtg tgtgtgaatg   2033

aacactcttg ctttattcca gaatgctgta catctatttt ggattgtata ttgtgtttgt   2093

gtatttacgc tttgattcat agtaacttct tatggaattg atttgcattg aacacaaact   2153

gtaaataaaa agaaatggct gaaagagcaa aaaaaaaaaa a                       2194


<210>  6
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly 
            20                  25                  30          


Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro 
        35                  40                  45              


Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser 
    50                  55                  60                  


Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser 
65                  70                  75                  80  


