                         SEQUENCE LISTING

<110>  Aura Biosciences, Inc.
       de los Pinos, Elisabet
       Kines, Rhonda
 
<120>  VIRION-DERIVED NANOSPHERES FOR SELECTIVE DELIVERY OF THERAPEUTIC 
       AND DIAGNOSTIC AGENTS TO CANCER CELLS

<130>  A0915.70007WO00

<140>  TBD
<141>  2013-02-07

<150>  61/596042
<151>  2012-02-07

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  10827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  1
ctagagccac catgagcctg tggctgccca gcgaggccac cgtgtacctg ccccccgtgc       60

ccgtgagcaa ggtggtgagc accgacgagt acgtggccag gaccaacatc tactaccacg      120

ccggcaccag caggctgctg gccgtgggcc acccctactt ccccatcaag aagcccaaca      180

acaacaagat cctggtgccc aaggtgagcg gcctgcagta cagggtgttc aggatccacc      240

tgcccgaccc caacaagttc ggcttccccg acaccagctt ctacaacccc gacacccaga      300

ggctggtgtg ggcctgcgtg ggcgtggagg tgggcagggg ccagcccctg ggcgtgggca      360

tcagcggcca ccccctgctg aacaagctgg acgacaccga gaacgccagc gcctacgccg      420

ccaacgccgg cgtggacaac agggagtgca tcagcatgga ctacaagcag acccagctgt      480

gcctgatcgg ctgcaagccc cccatcggcg agcactgggg caagggcagc ccctgcacca      540

acgtggccgt gaaccccggc gactgccccc ccctggagct gatcaacacc gtgatccagg      600

acggcgacat ggtggacacc ggcttcggcg ccatggactt caccaccctg caggccaaca      660

agagcgaggt gcccctggac atctgcacca gcatctgcaa gtaccccgac tacatcaaga      720

tggtgagcga gccctacggc gacagcctgt tcttctacct gaggagggag cagatgttcg      780

tgaggcacct gttcaacagg gccggcgccg tgggcgagaa cgtgcccacc gacctgtaca      840

tcaagggcag cggcagcacc gccaccctgg ccaacagcaa ctacttcccc acccccagcg      900

gcagcatggt gaccagcgac gcccagatct tcaacaagcc ctactggctg cagagggccc      960

agggccacaa caacggcatc tgctggggca accagctgtt cgtgaccgtg gtggacacca     1020

ccaggagcac caacatgagc ctgtgcgccg ccatcagcac cagcgagacc acctacaaga     1080

acaccaactt caaggagtac ctgaggcacg gcgaggagta cgacctgcag ttcatcttcc     1140

agctgtgcaa gatcaccctg accgccgacg tgatgaccta catccacagc atgaacagca     1200

ccatcctgga ggactggaac ttcggcctgc agcccccccc cggcggcacc ctggaggaca     1260

cctacaggtt cgtgaccagc caggccatcg cctgccagaa gcacaccccc cccgccccca     1320

aggaggaccc cctgaagaag tacaccttct gggaggtgaa cctgaaggag aagttcagcg     1380

ccgacctgga ccagttcccc ctgggcagga agttcctgct gcaggccggc ctgaaggcca     1440

agcccaagtt caccctgggc aagaggaagg ccacccccac caccagcagc accagcacca     1500

ccgccaagag gaagaagagg aagctgtgaa agcttatcga taccgtcgac ctcgacctgc     1560

agaagcttaa aacagctctg gggttgtacc caccccagag gcccacgtgg cggctagtac     1620

tccggtattg cggtaccctt gtacgcctgt tttatactcc cttcccgtaa cttagacgca     1680

caaaaccaag ttcaatagaa gggggtacaa accagtacca ccacgaacaa gcacttctgt     1740

ttccccggtg atgtcgtata gactgcttgc gtggttgaaa gcgacggatc cgttatccgc     1800

ttatgtactt cgagaagccc agtaccacct cggaatcttc gatgcgttgc gctcagcact     1860

caaccccaga gtgtagctta ggctgatgag tctggacatc cctcaccggt gacggtggtc     1920

caggctgcgt tggcggccta cctatggcta acgccatggg acgctagttg tgaacaaggt     1980

gtgaagagcc tattgagcta cataagaatc ctccggcccc tgaatgcggc taatcccaac     2040

ctcggagcag gtggtcacaa accagtgatt ggcctgtcgt aacgcgcaag tccgtggcgg     2100

aaccgactac tttgggtgtc cgtgtttcct tttattttat tgtggctgct tatggtgaca     2160

atcacagatt gttatcataa agcgaattgg attgcggccg ctctagagcc accatgaggc     2220

acaagaggag cgccaagagg accaagaggg ccagcgccac ccagctgtac aagacctgca     2280

agcaggccgg cacctgcccc cccgacatca tccccaaggt ggagggcaag accatcgccg     2340

accagatcct gcagtacggc agcatgggcg tgttcttcgg cggcctgggc atcggcaccg     2400

gcagcggcac cggcggcagg accggctaca tccccctggg caccaggccc cccaccgcca     2460

ccgacaccct ggcccccgtg aggccccccc tgaccgtgga ccccgtgggc cccagcgacc     2520

ccagcatcgt gagcctggtg gaggagacca gcttcatcga cgccggcgcc cccaccagcg     2580

tgcccagcat cccccccgac gtgagcggct tcagcatcac caccagcacc gacaccaccc     2640

ccgccatcct ggacatcaac aacaccgtga ccaccgtgac cacccacaac aaccccacct     2700

tcaccgaccc cagcgtgctg cagcccccca cccccgccga gaccggcggc cacttcaccc     2760

tgagcagcag caccatcagc acccacaact acgaggagat ccccatggac accttcatcg     2820

tgagcaccaa ccccaacacc gtgaccagca gcacccccat ccccggcagc aggcccgtgg     2880

ccaggctggg cctgtacagc aggaccaccc agcaggtgaa ggtggtggac cccgccttcg     2940

tgaccacccc caccaagctg atcacctacg acaaccccgc ctacgagggc atcgacgtgg     3000

acaacaccct gtacttcagc agcaacgaca acagcatcaa catcgccccc gaccccgact     3060

tcctggacat cgtggccctg cacaggcccg ccctgaccag caggaggacc ggcatcaggt     3120

acagcaggat cggcaacaag cagaccctga ggaccaggag cggcaagagc atcggcgcca     3180

aggtgcacta ctactacgac ctgagcacca tcgaccccgc cgaggagatc gagctgcaga     3240

ccatcacccc cagcacctac accaccacca gccacgccgc cagccccacc agcatcaaca     3300

acggcctgta cgacatctac gccgacgact tcatcaccga caccagcacc acccccgtgc     3360

ccagcgtgcc cagcaccagc ctgagcggct acatccccgc caacaccacc atccccttcg     3420

gtggcgccta caacatcccc ctggtgagcg gccccgacat ccccatcaac atcaccgacc     3480

aggcccccag cctgatcccc atcgtgcccg gcagccccca gtacaccatc atcgccgacg     3540

ccggcgactt ctacctgcac cccagctact acatgctgag gaagaggagg aagaggctgc     3600

cctacttctt cagcgacgtg agcctggccg cctgaaagct ttttgaattc tttggatcca     3660

ctagtggatc ccccgggctg caggaattcg atatcaagct tatcgataat caacctctgg     3720

attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct tttacgctat     3780

gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg gctttcattt     3840

tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg cccgttgtca     3900

ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt tggggcattg     3960

ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt gccacggcgg     4020

aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg ggcactgaca     4080

attccgtggt gttgtcgggg aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca     4140

cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat ccagcggacc     4200

ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc     4260

agacgagtcg gatctccctt tgggccgcct ccccgcatcg ataccgtcgg cccgtttaaa     4320

cccgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc     4380

ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg     4440

aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg     4500

acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta     4560

tggcttctga ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta     4620

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     4680

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     4740

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     4800

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat     4860

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     4920

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc     4980

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat     5040

tctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag     5100

tatgcaaagc atgcagaatt ctatcaaata tttaaagaaa aaaaaattgt atcaactttc     5160

tacaatctct ttcagaagac agaagcagag ggaatacttc ctaaatcatt caactaggcc     5220

agcattacct taataccgga actagaaaat gacattacaa gaaaagaaaa caacagacca     5280

atatctctca tgaacaaaga tacaaacatt ttcaacaaaa tattagcaaa aagaatccaa     5340

gaatgtatca aaaaatatac accacaacca agtagaattt attccagata tgtaagggtg     5400

gttcaacgtt tgaaaatcaa ttaacgtaat ttgtcccatc aacaggttaa agaagaaaat     5460

cacatggtca tattgataga cacagaaaaa gcatttgaca aaatttaaca cccattcatg     5520

atgcaatctc tcagtaaact aggaatagag gaaaacttcc tcagcttgaa tgtaccttcc     5580

tctcaatttt gctatgaacc tgaaactcct cttaaaaaat aaagtttttc atttaaaaag     5640

aaaacaaaaa acatggagga gcgttgatgt atctcatttt agaccaatca gctatggata     5700

gttaggcgac agcacagata gctgctgtac ttctgtttct ggcaatgttc cagactacat     5760

ttaaaaaatt tttaattata gacttgtact taatgttcaa gaaaaatatg aaaatggctt     5820

tgccgtgtta atgctactct tttttaaaaa aaactaaagt tcaaacttta tttatatttc     5880

attagttttt tagctactgt tctttttctg ttctgggatc tcattcagaa tgccacatta     5940

catataattc tcatgtctcc ttgggttcct cttagttttg acagttcctc agacttttct     6000

tatttttgat gaccttgaca gttttgagga gtactggtta gatatagggt aatggttttt     6060

aaagtatatt tgtcatgatt tatactgggg taagggtttg gggaggaagc ccatggggta     6120

aagtactgtt ctcatcacat catatcaagg ttatatacca tcaatattgc cacagatgtt     6180

acttagcctt ttaatatttc tctaatttag tgtatatgca atgatagttc tctgatttct     6240

gagattgagt ttctcatgtg taatgattat ttagagtttc tctttcatct gttcaaattt     6300

ttgtctagtt ttatttttta ctgatttgta agacttcttt ttataatctg catattacaa     6360

ttctctttac tggggtgttg caaatatttt ctgtcattct atggcctgac ttttcttaat     6420

ggttttttaa ttttaaaaat aagtcttaat attcatgcaa tctaattaac aatcttttct     6480

ttgtggttag gactttgagt cataagaaat ttttctctac actgaagtca tgatggcatg     6540

cttctatatt attttctaaa agatttaaag ttttgccttc tccatttaga cttataattc     6600

actggaattt ttttgtgtgt atggtatgac atatgggttc ccttttattt tttacatata     6660

aatatatttc cctgtttttc taaaaaagaa aaagatcatc attttcccat tgtaaaatgc     6720

catatttttt tcataggtca cttacatata tcaatgggtc tgtttctgag ctctactcta     6780

ttttatcagc ctcactgtct atccccacac atctcatgct ttgctctaaa tcttgatatt     6840

tagtggaaca ttctttccca ttttgttcta caagaatatt tttgttattg tcttttgggc     6900

ttctatatac attttagaat gaggttggca agttaacaaa cagctttttt ggggtgaaca     6960

tattgactac aaatttatgt ggaaagaaag taccaagttg accagtgccg ttccggtgct     7020

caccgcgcgc gacgtcgccg gagcggtcga gttctggacc gaccggctcg ggttctcccg     7080

ggacttcgtg gaggacgact tcgccggtgt ggtccgggac gacgtgaccc tgttcatcag     7140

cgcggtccag gaccaggtgg tgccggacaa caccctggcc tgggtgtggg tgcgcggcct     7200

ggacgagctg tacgccgagt ggtcggaggt cgtgtccacg aacttccggg acgcctccgg     7260

gccggccatg accgagatcg gcgagcagcc gtgggggcgg gagttcgccc tgcgcgaccc     7320

ggccggcaac tgcgtgcact tcgtggccga ggagcaggac tgacacgtgc tacgagattt     7380

cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc gggacgccgg     7440

ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc ccaacttgtt     7500

tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc     7560

atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt     7620

ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc tgtttcctgt     7680

gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa     7740

agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc     7800

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag     7860

aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt     7920

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     7980

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     8040

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     8100

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     8160

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     8220

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     8280

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     8340

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     8400

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     8460

tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat     8520

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     8580

acaaaccacc gctggtagcg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     8640

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     8700

ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt     8760

aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag     8820

ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat     8880

agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc     8940

cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa     9000

ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca     9060

gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa     9120

cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt     9180

cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc     9240

ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact     9300

catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc     9360

tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg     9420

ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct     9480

catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc     9540

cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag     9600

cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac     9660

acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg     9720

ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt     9780

tccgcgcaca tttccccgaa aagtgccacc tgacgtcgac ggatcgggag atctcccgat     9840

cccctatggt gcactctcag tacaatctgc tctgatgccg catagttaag ccagtatctg     9900

ctccctgctt gtgtgttgga ggtcgctgag tagtgcgcga gcaaaattta agctacaaca     9960

aggcaaggct tgaccgacaa ttgcatgaag aatctgctta gggttaggcg ttttgcgctg    10020

cttcgcgatg tacgggccag atatacgcgt tgacattgat tattgactag ttattaatag    10080

taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt    10140

acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg    10200

acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat    10260

ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct    10320

attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg    10380

gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg    10440

ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc    10500

caccccattg acgtcaatgg gagtttgttt tggaaccaaa atcaacggga ctttccaaaa    10560

tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc    10620

tatataagca gagctctccc tatcagtgat agagatctcc ctatcagtga tagagatcgt    10680

cgacgagctc gtttagtgaa ccgtcagatc gcctggagac gccatccacg ctgttttgac    10740

ctccatagaa gacaccggga ccgatccagc ctccggactc tagcgtttaa acttaaggct    10800

agagtactta atacgactca ctatagg                                        10827


<210>  2
<211>  1516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  2
atgagcctgt ggctgcccag cgaggccacc gtgtacctgc cccccgtgcc cgtgagcaag       60

gtggtgagca ccgacgagta cgtggccaga accaacatct actaccacgc cggcaccagc      120

agactgctgg ccgtgggcca cccctacttc cccatcaaga agcccaacaa caacaagatc      180

ctggtgccca aggtgagcgg cctgcagtac agagtgttca gaatccacct gcccgacccc      240

aacaagttcg gcttccccga caccagcttc tacaaccccg acacccagag actggtgtgg      300

gcctgcgtgg gcgtggaggt gggcagaggc cagcccctgg gcgtgggcat cagcggccac      360

cccctgctga acaagctgga cgacaccgag aacgccagcg cctacgccgc caacgccggc      420

gtggacaaca gagagtgcat cagcatggac tacaagcaga cccagctgtg cctgatcggc      480

tgcaagcccc ccatcggcga gcactggggc aagggcagcc cctgcaccaa cgtggccgtg      540

aaccccggcg actgcccccc cctggagctg atcaacaccg tgatccagga cggcgacatg      600

gtggacaccg gcttcggcgc catggacttc accaccctgc aggccaacaa gagcgaggtg      660

cccctggaca tctgcaccag catctgcaag taccccgact acatcaagat ggtgagcgag      720

ccctacggcg acagcctgtt cttctacctg agaagagagc agatgttcgt gagacacctg      780

ttcaacagag ccggcgccgt gggcgagaac gtgcccaccg acctgtacat caagggcagc      840

ggcagcaccg ccaccctggc caacagcaac tacttcccca cccccagcgg cagcatggtg      900

accagcgacg cccagatctt caacaagccc tactggctgc agagagccca gggccacaac      960

aacggcatct gctggggcaa ccagctgttc gtgaccgtgg tggacaccac cagaagcacc     1020

aacatgagcc tgtgcgccgc catcagcacc agcgagacca cctacaagaa caccaacttc     1080

aaggagtacc tgagacacgg cgaggagtac gacctgcagt tcatcttcca gctgtgcaag     1140

atcaccctga ccgccgacgt gatgacctac atccacagca tgaacagcac catcctggag     1200

gactggaact tcggcctgca gccccccccc ggcggcaccc tggaggacac ctacagattc     1260

gtgaccagcc aggccatcgc ctgccagaag cacacccccc ccgcccccaa ggaggacccc     1320

ctgaagaagt acaccttctg ggaggtgaac ctgaaggaga agttcagcgc cgacctggac     1380

cagttccccc tgggcagaaa gttcctgctg caggccggcc tgaaggccaa gcccaagttc     1440

accctgggca agagaaaggc cacccccacc accagcagca ccagcaccac cgccaagaga     1500

aagaagagaa agctga                                                     1516


<210>  3
<211>  6754
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  3
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtcattac agtttacgct      180

tcttacgctt cgcggtggtg ctagtgctgc tggtggtcgg cgtggccttg cgcttgccca      240

gggtaaactt cggttttgcc ttcagacccg cttgcagcag gaatttgcgg cccagcggaa      300

actggtccaa atcagccgag aatttctctt tcagattgac ctcccaaaag gtgtatttct      360

tcagcggatc ttctttcggt gccggtgggg tatgcttctg acacgcgatt gcctgggagg      420

taacaaaacg gtacgtatcc tccagcgtgc cgccaggcgg aggttgcaga ccgaagttcc      480

aatcctccag aatcgtgctg ttcatgctat gaatgtagct catcacgtcc gccgtcaggg      540

tgattttaca cagctgaaaa atgaattgca gatcatattc ttcgccgtga cgcagatatt      600

ctttaaagtt ggtattctta taggtcggct cgctggtcga gatcgctgca cacaggctca      660

tattcgtgct gcgcgtagtg tcaaccacgg taacaaacag ttgattaccc cagcaaatac      720

cattattgtg accctgtgca cgttgcagcc agtaaggctt attgaaaatc tgagcatcgc      780

tagtaaccat gctgccgctt ggcgtcggaa agtaattgct gttcgccaac gtcgcggtgc      840

taccgctacc tttgatgtac aggtcagtcg gcacgttctc acccacggca cctgcgcgat      900

tgaacaggtg acggacgaac atttgctcgc gacgcaggta aaagaacagg ctgtcaccat      960

acggttcgct gaccattttg atatagtccg ggtacttgca gatagaggtg caaatgtcca     1020

acggaacctc gctcttgttg gcctgcaagg tggtaaagtc catcgcacca aagcccgtat     1080

ccaccatatc accatcttga atcaccgtat tgatcagttc cagcggtggg caatcacccg     1140

gattcaccgc cacgttattg cacgggctac ctttacccca gtgctcaccg atcggcggtt     1200

tacaaccgat caggcacagc tgggtttgct tatagtccat cgaaatgcat tcacgattat     1260

ccacgcctgc gttcgcggcg taggcagaag cgttctcggt atcgtccagt ttgttcagca     1320

gcggatggcc ggagatgccg acgcccagcg gctgaccacg accaacctca acgccgacac     1380

acgcccaaac cagacgctgc gtgtccgggt tatagaagct ggtgtccggg aaaccgaatt     1440

tgttcgggtc acgcagatga atgcggaaca cacgatattg caagccgctg accttcggta     1500

ccagaatttt gttgttgttc ggtttcttaa tcgggaaata cgggtgaccc acggccaaca     1560

ggcgggacgt acccgcgtgg tagtagatat tggtgcgcgc gacgtattcg tcggtagaga     1620

caaccttgct aactgggaca ggcggtaagt acacggtcgc ttcgctcggg agccacaggg     1680

acattttttt tatctccttt aaagttaaac aaaattattt ctagagggga attgttatcc     1740

gctcacaatt cccctatagt gagtcgtatt aatttcgcgg gatcgagatc tcgatcctct     1800

acgccggacg catcgtggcc ggcatcaccg gcgccacagg tgcggttgct ggcgcctata     1860

tcgccgacat caccgatggg gaagatcggg ctcgccactt cgggctcatg agcgcttgtt     1920

tcggcgtggg tatggtggca ggccccgtgg ccgggggact gttgggcgcc atctccttgc     1980

atgcaccatt ccttgcggcg gcggtgctca acggcctcaa cctactactg ggctgcttcc     2040

taatgcagga gtcgcataag ggagagcgtc gagatcccgg acaccatcga atggcgcaaa     2100

acctttcgcg gtatggcatg atagcgcccg gaagagagtc aattcagggt ggtgaatgtg     2160

aaaccagtaa cgttatacga tgtcgcagag tatgccggtg tctcttatca gaccgtttcc     2220

cgcgtggtga accaggccag ccacgtttct gcgaaaacgc gggaaaaagt ggaagcggcg     2280

atggcggagc tgaattacat tcccaaccgc gtggcacaac aactggcggg caaacagtcg     2340

ttgctgattg gcgttgccac ctccagtctg gccctgcacg cgccgtcgca aattgtcgcg     2400

gcgattaaat ctcgcgccga tcaactgggt gccagcgtgg tggtgtcgat ggtagaacga     2460

agcggcgtcg aagcctgtaa agcggcggtg cacaatcttc tcgcgcaacg cgtcagtggg     2520

ctgatcatta actatccgct ggatgaccag gatgccattg ctgtggaagc tgcctgcact     2580

aatgttccgg cgttatttct tgatgtctct gaccagacac ccatcaacag tattattttc     2640

tcccatgaag acggtacgcg actgggcgtg gagcatctgg tcgcattggg tcaccagcaa     2700

atcgcgctgt tagcgggccc attaagttct gtctcggcgc gtctgcgtct ggctggctgg     2760

cataaatatc tcactcgcaa tcaaattcag ccgatagcgg aacgggaagg cgactggagt     2820

gccatgtccg gttttcaaca aaccatgcaa atgctgaatg agggcatcgt tcccactgcg     2880

atgctggttg ccaacgatca gatggcgctg ggcgcaatgc gcgccattac cgagtccggg     2940

ctgcgcgttg gtgcggatat ctcggtagtg ggatacgacg ataccgaaga cagctcatgt     3000

tatatcccgc cgttaaccac catcaaacag gattttcgcc tgctggggca aaccagcgtg     3060

gaccgcttgc tgcaactctc tcagggccag gcggtgaagg gcaatcagct gttgcccgtc     3120

tcactggtga aaagaaaaac caccctggcg cccaatacgc aaaccgcctc tccccgcgcg     3180

ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag cgggcagtga     3240

gcgcaacgca attaatgtaa gttagctcac tcattaggca ccgggatctc gaccgatgcc     3300

cttgagagcc ttcaacccag tcagctcctt ccggtgggcg cggggcatga ctatcgtcgc     3360

cgcacttatg actgtcttct ttatcatgca actcgtagga caggtgccgg cagcgctctg     3420

ggtcattttc ggcgaggacc gctttcgctg gagcgcgacg atgatcggcc tgtcgcttgc     3480

ggtattcgga atcttgcacg ccctcgctca agccttcgtc actggtcccg ccaccaaacg     3540

tttcggcgag aagcaggcca ttatcgccgg catggcggcc ccacgggtgc gcatgatcgt     3600

gctcctgtcg ttgaggaccc ggctaggctg gcggggttgc cttactggtt agcagaatga     3660

atcaccgata cgcgagcgaa cgtgaagcga ctgctgctgc aaaacgtctg cgacctgagc     3720

aacaacatga atggtcttcg gtttccgtgt ttcgtaaagt ctggaaacgc ggaagtcagc     3780

gccctgcacc attatgttcc ggatctgcat cgcaggatgc tgctggctac cctgtggaac     3840

acctacatct gtattaacga agcgctggca ttgaccctga gtgatttttc tctggtcccg     3900

ccgcatccat accgccagtt gtttaccctc acaacgttcc agtaaccggg catgttcatc     3960

atcagtaacc cgtatcgtga gcatcctctc tcgtttcatc ggtatcatta cccccatgaa     4020

cagaaatccc ccttacacgg aggcatcagt gaccaaacag gaaaaaaccg cccttaacat     4080

ggcccgcttt atcagaagcc agacattaac gcttctggag aaactcaacg agctggacgc     4140

ggatgaacag gcagacatct gtgaatcgct tcacgaccac gctgatgagc tttaccgcag     4200

ctgcctcgcg cgtttcggtg atgacggtga aaacctctga cacatgcagc tcccggagac     4260

ggtcacagct tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc     4320

gggtgttggc gggtgtcggg gcgcagccat gacccagtca cgtagcgata gcggagtgta     4380

tactggctta actatgcggc atcagagcag attgtactga gagtgcacca tatatgcggt     4440

gtgaaatacc gcacagatgc gtaaggagaa aataccgcat caggcgctct tccgcttcct     4500

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     4560

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     4620

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     4680

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     4740

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     4800

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     4860

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     4920

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     4980

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     5040

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     5100

acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     5160

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     5220

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     5280

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgaacaata     5340

aaactgtctg cttacataaa cagtaataca aggggtgtta tgagccatat tcaacgggaa     5400

acgtcttgct ctaggccgcg attaaattcc aacatggatg ctgatttata tgggtataaa     5460

tgggctcgcg ataatgtcgg gcaatcaggt gcgacaatct atcgattgta tgggaagccc     5520

gatgcgccag agttgtttct gaaacatggc aaaggtagcg ttgccaatga tgttacagat     5580

gagatggtca gactaaactg gctgacggaa tttatgcctc ttccgaccat caagcatttt     5640

atccgtactc ctgatgatgc atggttactc accactgcga tccccgggaa aacagcattc     5700

caggtattag aagaatatcc tgattcaggt gaaaatattg ttgatgcgct ggcagtgttc     5760

ctgcgccggt tgcattcgat tcctgtttgt aattgtcctt ttaacagcga tcgcgtattt     5820

cgtctcgctc aggcgcaatc acgaatgaat aacggtttgg ttgatgcgag tgattttgat     5880

gacgagcgta atggctggcc tgttgaacaa gtctggaaag aaatgcataa acttttgcca     5940

ttctcaccgg attcagtcgt cactcatggt gatttctcac ttgataacct tatttttgac     6000

gaggggaaat taataggttg tattgatgtt ggacgagtcg gaatcgcaga ccgataccag     6060

gatcttgcca tcctatggaa ctgcctcggt gagttttctc cttcattaca gaaacggctt     6120

tttcaaaaat atggtattga taatcctgat atgaataaat tgcagtttca tttgatgctc     6180

gatgagtttt tctaagaatt aattcatgag cggatacata tttgaatgta tttagaaaaa     6240

taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgaaa ttgtaaacgt     6300

taatattttg ttaaaattcg cgttaaattt ttgttaaatc agctcatttt ttaaccaata     6360

ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag accgagatag ggttgagtgt     6420

tgttccagtt tggaacaaga gtccactatt aaagaacgtg gactccaacg tcaaagggcg     6480

aaaaaccgtc tatcagggcg atggcccact acgtgaacca tcaccctaat caagtttttt     6540

ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa gggagccccc gatttagagc     6600

ttgacgggga aagccggcga acgtggcgag aaaggaaggg aagaaagcga aaggagcggg     6660

cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta accaccacac ccgccgcgct     6720

taatgcgccg ctacagggcg cgtcccattc gcca                                 6754


<210>  4
<211>  5386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  4
aagaaaccaa ttgtccatat tgcatcagac attgccgtca ctgcgtcttt tactggctct       60

tctcgctaac caaaccggta accccgctta ttaaaagcat tctgtaacaa agcgggacca      120

aagccatgac aaaaacgcgt aacaaaagtg tctataatca cggcagaaaa gtccacattg      180

attatttgca cggcgtcaca ctttgctatg ccatagcatt tttatccata agattagcgg      240

atcctacctg acgcttttta tcgcaactct ctactgtttc tccatacccg ttttttgggc      300

taacaggagg aattaaccat gagacacaaa agatcagcca aacgtacgaa gagagcaagc      360

gcgacccaac tgtataagac ctgcaaacag gcgggtactt gtccgcctga catcatccct      420

aaggttgagg gtaagaccat cgcggatcaa attctgcaat acggcagcat gggcgttttc      480

tttggtggcc tgggtattgg tacgggtagc ggcaccggcg gtcgtaccgg ctacatcccg      540

ctgggcaccc gcccaccgac cgccaccgat acgctggccc cagtgcgtcc gccgctgacc      600

gtcgatccgg ttggcccgtc cgacccgagc attgttagcc tggtggaaga aaccagcttc      660

attgatgcgg gtgctcctac gagcgttccg tctatcccgc cagacgtgag cggttttagc      720

attacgacga gcaccgatac caccccggct attttggaca ttaacaacac ggtgactacc      780

gtgaccaccc acaacaatcc tacctttact gacccaagcg tgttgcaacc gccgaccccg      840

gcagaaacgg gtggccactt caccctgagc agctccacca tcagcacgca caattatgaa      900

gagattccga tggacacctt tatcgtatct acgaatccga atacggtcac gagcagcacc      960

ccgattccgg gctcccgtcc ggtcgcgcgt ctgggtctgt actcccgtac cacccagcag     1020

gttaaagtcg ttgacccggc gtttgttacg accccgacga agctgattac ctatgacaat     1080

ccggcctacg agggcattga cgttgataac accctgtact tcagcagcaa cgataatagc     1140

atcaatattg caccggaccc tgattttctg gacatcgtcg cactgcaccg tccggcgctg     1200

acgagccgtc gcacgggtat tcgttattcc cgcatcggca acaaacaaac cctgcgcacc     1260

cgttcgggta agtctatcgg cgcaaaagtc cattactatt acgacctgtc taccatcgat     1320

ccggcggaag agattgagtt gcagacgatt actccgagca cctacaccac tacgtcccat     1380

gcagcgagcc cgaccagcat caacaatggt ctgtacgaca tctatgcgga tgactttatc     1440

actgatacga gcaccacgcc ggtcccgagc gtgccgagca ccagcctgtc gggctatatc     1500

ccggccaaca ccacgattcc gttcggtggt gcgtataaca tcccgttggt gagcggtcca     1560

gacatcccga tcaacattac ggatcaggca ccgagcctga ttccgatcgt cccgggtagc     1620

ccacagtaca ccatcattgc tgatgcaggt gacttctacc tgcatccgtc ttactatatg     1680

ttgcgtaaac gccgcaagcg tctgccgtac ttcttctcgg atgtgagcct ggcggcgtaa     1740

tgaattcgaa gcttggctgt tttggcggat gagagaagat tttcagcctg atacagatta     1800

aatcagaacg cagaagcggt ctgataaaac agaatttgcc tggcggcagt agcgcggtgg     1860

tcccacctga ccccatgccg aactcagaag tgaaacgccg tagcgccgat ggtagtgtgg     1920

ggtctcccca tgcgagagta gggaactgcc aggcatcaaa taaaacgaaa ggctcagtcg     1980

aaagactggg cctttcgttt tatctgttgt ttgtcggtga acgctctcct gagtaggaca     2040

aatccgccgg gagcggattt gaacgttgcg aagcaacggc ccggagggtg gcgggcagga     2100

cgcccgccat aaactgccag gcatcaaatt aagcagaagg ccatcctgac ggatggcctt     2160

tttgcgtttc tacaaactct tttgtttatt tttctaaata cattcaaata tgtatccgct     2220

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     2280

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     2340

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     2400

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     2460

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtgttga     2520

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     2580

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     2640

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     2700

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     2760

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     2820

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     2880

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     2940

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     3000

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     3060

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     3120

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     3180

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     3240

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     3300

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     3360

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     3420

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     3480

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     3540

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     3600

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     3660

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     3720

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     3780

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     3840

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     3900

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     3960

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     4020

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgcct     4080

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct     4140

cagtacaatc tgctctgatg ccgcatagtt aagccagtat acactccgct atcgctacgt     4200

gactgggtca tggctgcgcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct     4260

tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt     4320

cagaggtttt caccgtcatc accgaaacgc gcgaggcagc agatcaattc gcgcgcgaag     4380

gcgaagcggc atgcataatg tgcctgtcaa atggacgaag cagggattct gcaaacccta     4440

tgctactccg tcaagccgtc aattgtctga ttcgttacca attatgacaa cttgacggct     4500

acatcattca ctttttcttc acaaccggca cggaactcgc tcgggctggc cccggtgcat     4560

tttttaaata cccgcgagaa atagagttga tcgtcaaaac caacattgcg accgacggtg     4620

gcgataggca tccgggtggt gctcaaaagc agcttcgcct ggctgatacg ttggtcctcg     4680

cgccagctta agacgctaat ccctaactgc tggcggaaaa gatgtgacag acgcgacggc     4740

gacaagcaaa catgctgtgc gacgctggcg atatcaaaat tgctgtctgc caggtgatcg     4800

ctgatgtact gacaagcctc gcgtacccga ttatccatcg gtggatggag cgactcgtta     4860

atcgcttcca tgcgccgcag taacaattgc tcaagcagat ttatcgccag cagctccgaa     4920

tagcgccctt ccccttgccc ggcgttaatg atttgcccaa acaggtcgct gaaatgcggc     4980

tggtgcgctt catccgggcg aaagaacccc gtattggcaa atattgacgg ccagttaagc     5040

cattcatgcc agtaggcgcg cggacgaaag taaacccact ggtgatacca ttcgcgagcc     5100

tccggatgac gaccgtagtg atgaatctct cctggcggga acagcaaaat atcacccggt     5160

cggcaaacaa attctcgtcc ctgatttttc accaccccct gaccgcgaat ggtgagattg     5220

agaatataac ctttcattcc cagcggtcgg tcgataaaaa aatcgagata accgttggcc     5280

tcaatcggcg ttaaacccgc caccagatgg gcattaaacg agtatcccgg cagcagggga     5340

tcattttgcg cttcagccat acttttcata ctcccgccat tcagag                    5386


