                               SEQUENCE LISTING

<110> GENENTECH, INC. ET AL.
 
<120> SINGLE-CHAIN ANTIBODIES AND OTHER HETEROMULTIMERS

<130> P4733R1-WO

<140>
<141>

<150> 61/597,486
<151> 2012-02-10

<160> 21    

<170> PatentIn version 3.5

<210> 1
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 1
Thr His Thr 
1           


<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Gly Gly Gly Ser Thr His Thr 
1               5           


<210> 3
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Gly Gly Gly Ser Gly Gly Gly Ser Thr His Thr 
1               5                   10      


<210> 4
<211> 7
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: Cleavage site
      peptide cleaved by TEV"

<400> 4
Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210> 5
<211> 9
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: Cleavage site 
      peptide for Hedgehog protein"

<400> 5
Gly Asp Trp Asn Ala Arg Trp Cys Phe 
1               5                   


<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any basic amino acid

<220>
<221> MOD_RES
<222> (2)..(3)
<223> Any amino acid

<220>
<221> source
<223> /note="see specification as filed for detailed description
      of substitutions and preferred embodiments"

<400> 6
Xaa Xaa Xaa Arg 
1               


<210> 7
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (5)..(5)
<223> /note="Residue given in the sequence has no preference 
      with respect to the annotation for said position"

<400> 7
Arg Xaa Arg Xaa Lys Arg 
1               5       


<210> 8
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 8
Arg Xaa Arg Xaa Arg Arg 
1               5       


<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Arg Lys Arg Lys Arg Arg 
1               5       


<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Arg His Arg Gln Pro Arg 
1               5       


<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Arg Ser Arg Lys Arg Arg 
1               5       


<210> 12
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<400> 12
cncaat                                                                   6


<210> 13
<211> 6
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
aataaa                                                                   6


<210> 14
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Arg Lys Arg Lys Arg Arg Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Arg Ser Arg Lys Arg Arg 
            20                  25                  30          


<210> 15
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Arg Ser Arg Lys Arg Arg 
            20                  25                  30  


<210> 16
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Arg Ser Arg Lys Arg 
            20                  25                  30          


Arg 
    


<210> 17
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Arg Ser 
            20                  25                  30          


Arg Lys Arg Arg 
        35      


<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Arg Lys Arg Lys Arg 
1               5   


<210> 19
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (25)..(27)
<223> /replace=" "

<220>
<221> misc_feature
<222> (25)..(27)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> misc_feature
<222> (1)..(27)
<223> /note="This sequence may encompass 8 to 9 "Gly Gly Ser"
      repeating units

<400> 19
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            20                  25          


<210> 20
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210> 21
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      10xHis tag"

<400> 21
His His His His His His His His His His 
1               5                   10      



