                         SEQUENCE LISTING

<110>  PROLOR BIOTECH INC.
       FIMA, UDI EYAL
       HART, GILI
 
<120>  LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME

<130>  P-9520-PC5

<150>  13/372,540
<151>  2012-02-14

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
1               5                   10                  15      


Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
            20                  25                  30          


<210>  2
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro 
1               5                   10          


<210>  4
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for Factor VII

<400>  5
ctcgaggaca tggtctccca ggccc                                             25


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for Factor VII

<400>  6
tctagaatag gtatttttcc acat                                              24


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for Factor VII

<400>  7
tctagaaaaa agaaatgcca gc                                                22


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer for Factor VII

<400>  8
gcggccgcat cctcagggaa atggggctcg ca                                     32


<210>  9
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro 
        435                 440                 


<210>  10
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Cys Gly Arg 
        435                 440                 445             


<210>  11
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  11
ctcgaggaca tggtctccca ggccctcagg ctcctctgcc ttctgcttgg gcttcagggc       60

tgcctggctg cagtcttcgt aacccaggag gaagcccacg gcgtcctgca ccggcgccgg      120

cgcgccaacg cgttcctgga ggagctgcgg ccgggctccc tggagaggga gtgcaaggag      180

gagcagtgct ccttcgagga ggcccgggag atcttcaagg acgcggagag gacgaagctg      240

ttctggattt cttacagtga tggggaccag tgtgcctcaa gtccatgcca gaatgggggc      300

tcctgcaagg accagctcca gtcctatatc tgcttctgcc tccctgcctt cgagggccgg      360

aactgtgaga cgcacaagga tgaccagctg atctgtgtga acgagaacgg cggctgtgag      420

cagtactgca gtgaccacac gggcaccaag cgctcctgtc ggtgccacga ggggtactct      480

ctgctggcag acggggtgtc ctgcacaccc acagttgaat atccatgtgg aaaaatacct      540

attctagaaa aaagaaatgc cagcaaaccc caaggccgaa ttgtgggggg caaggtgtgc      600

cccaaagggg agtgtccatg gcaggtcctg ttgttggtga atggagctca gttgtgtggg      660

gggaccctga tcaacaccat ctgggtggtc tccgcggccc actgtttcga caaaatcaag      720

aactggagga acctgatcgc ggtgctgggc gagcacgacc tcagcgagca cgacggggat      780

gagcagagcc ggcgggtggc gcaggtcatc atccccagca cgtacgtccc gggcaccacc      840

aaccacgaca tcgcgctgct ccgcctgcac cagcccgtgg tcctcactga ccatgtggtg      900

cccctctgcc tgcccgaacg gacgttctct gagaggacgc tggccttcgt gcgcttctca      960

ttggtcagcg gctggggcca gctgctggac cgtggcgcca cggccctgga gctcatggtc     1020

ctcaacgtgc cccggctgat gacccaggac tgcctgcagc agtcacggaa ggtgggagac     1080

tccccaaata tcacggagta catgttctgt gccggctact cggatggcag caaggactcc     1140

tgcaaggggg acagtggagg cccacatgcc acccactacc ggggcacgtg gtacctgacg     1200

ggcatcgtca gctggggcca gggctgcgca accgtgggcc actttggggt gtacaccagg     1260

gtctcccagt acatcgagtg gctgcaaaag ctcatgcgct cagagccacg cccaggagtc     1320

ctcctgcgag ccccatttcc ctgaggatgc ggccgc                               1356


<210>  12
<211>  1442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  12
ctcgaggaca tggtctccca ggccctcagg ctcctctgcc ttctgcttgg gcttcagggc       60

tgcctggctg cagtcttcgt aacccaggag gaagcccacg gcgtcctgca ccggcgccgg      120

cgcgccaacg cgttcctgga ggagctgcgg ccgggctccc tggagaggga gtgcaaggag      180

gagcagtgct ccttcgagga ggcccgggag atcttcaagg acgcggagag gacgaagctg      240

ttctggattt cttacagtga tggggaccag tgtgcctcaa gtccatgcca gaatgggggc      300

tcctgcaagg accagctcca gtcctatatc tgcttctgcc tccctgcctt cgagggccgg      360

aactgtgaga cgcacaagga tgaccagctg atctgtgtga acgagaacgg cggctgtgag      420

cagtactgca gtgaccacac gggcaccaag cgctcctgtc ggtgccacga ggggtactct      480

ctgctggcag acggggtgtc ctgcacaccc acagttgaat atccatgtgg aaaaatacct      540

attctagaaa aaagaaatgc cagcaaaccc caaggccgaa ttgtgggggg caaggtgtgc      600

cccaaagggg agtgtccatg gcaggtcctg ttgttggtga atggagctca gttgtgtggg      660

gggaccctga tcaacaccat ctgggtggtc tccgcggccc actgtttcga caaaatcaag      720

aactggagga acctgatcgc ggtgctgggc gagcacgacc tcagcgagca cgacggggat      780

gagcagagcc ggcgggtggc gcaggtcatc atccccagca cgtacgtccc gggcaccacc      840

aaccacgaca tcgcgctgct ccgcctgcac cagcccgtgg tcctcactga ccatgtggtg      900

cccctctgcc tgcccgaacg gacgttctct gagaggacgc tggccttcgt gcgcttctca      960

ttggtcagcg gctggggcca gctgctggac cgtggcgcca cggccctgga gctcatggtc     1020

ctcaacgtgc cccggctgat gacccaggac tgcctgcagc agtcacggaa ggtgggagac     1080

tccccaaata tcacggagta catgttctgt gccggctact cggatggcag caaggactcc     1140

tgcaaggggg acagtggagg cccacatgcc acccactacc ggggcacgtg gtacctgacc     1200

ggcatcgtga gctggggcca gggctgcgcc accgtgggcc acttcggcgt gtacaccagg     1260

gtgtcccagt acatcgagtg gctgcagaaa ctgatgagaa gcgagcccag acccggcgtg     1320

ctgctgagag cccccttccc cagcagcagc tccaaggccc ctccccctag cctgcccagc     1380

cctagcagac tgcctgggcc cagcgacacc cccatcctgc cccagtgagg atccgcggcc     1440

gc                                                                    1442


<210>  13
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  13

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Ser Ser Ser Ser 
        435                 440                 445             


Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro 
    450                 455                 460                 


Ser Asp Thr Pro Ile Leu Pro Gln 
465                 470         


<210>  14
<211>  1535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  14
ctcgaggaca tggtctccca ggccctcagg ctcctctgcc ttctgcttgg gcttcagggc       60

tgcctggctg cagtcttcgt aacccaggag gaagcccacg gcgtcctgca ccggcgccgg      120

cgcgccaacg cgttcctgga ggagctgcgg ccgggctccc tggagaggga gtgcaaggag      180

gagcagtgct ccttcgagga ggcccgggag atcttcaagg acgcggagag gacgaagctg      240

ttctggattt cttacagtga tggggaccag tgtgcctcaa gtccatgcca gaatgggggc      300

tcctgcaagg accagctcca gtcctatatc tgcttctgcc tccctgcctt cgagggccgg      360

aactgtgaga cgcacaagga tgaccagctg atctgtgtga acgagaacgg cggctgtgag      420

cagtactgca gtgaccacac gggcaccaag cgctcctgtc ggtgccacga ggggtactct      480

ctgctggcag acggggtgtc ctgcacaccc acagttgaat atccatgtgg aaaaatacct      540

attctagaaa aaagaaatgc cagcaaaccc caaggccgaa ttgtgggggg caaggtgtgc      600

cccaaagggg agtgtccatg gcaggtcctg ttgttggtga atggagctca gttgtgtggg      660

gggaccctga tcaacaccat ctgggtggtc tccgcggccc actgtttcga caaaatcaag      720

aactggagga acctgatcgc ggtgctgggc gagcacgacc tcagcgagca cgacggggat      780

gagcagagcc ggcgggtggc gcaggtcatc atccccagca cgtacgtccc gggcaccacc      840

aaccacgaca tcgcgctgct ccgcctgcac cagcccgtgg tcctcactga ccatgtggtg      900

cccctctgcc tgcccgaacg gacgttctct gagaggacgc tggccttcgt gcgcttctca      960

ttggtcagcg gctggggcca gctgctggac cgtggcgcca cggccctgga gctcatggtc     1020

ctcaacgtgc cccggctgat gacccaggac tgcctgcagc agtcacggaa ggtgggagac     1080

tccccaaata tcacggagta catgttctgt gccggctact cggatggcag caaggactcc     1140

tgcaaggggg acagtggagg cccacatgcc acccactacc ggggcacgtg gtacctgacc     1200

ggcatcgtga gctggggcca gggctgcgcc accgtgggcc acttcggcgt gtacaccagg     1260

gtgtcccagt acatcgagtg gctgcagaaa ctgatgagaa gcgagcccag acccggcgtg     1320

ctgctgagag cccccttccc cagcagcagc tccaaggccc ctccccctag cctgcccagc     1380

cctagcagac tgcctgggcc ctccgacaca ccaatcctgc cacagagcag ctcctctaag     1440

gcccctcctc catccctgcc atccccctcc cggctgccag gcccctctga cacccctatc     1500

ctgcctcagt gatgaaggtc tggatccgcg gccgc                                1535


<210>  15
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  15

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Ser Ser Ser Ser 
        435                 440                 445             


Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro 
    450                 455                 460                 


Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro 
465                 470                 475                 480 


Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro 
                485                 490                 495     


Ile Leu Pro Gln 
            500 


<210>  16
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  16
gcgatcgcca tgcagcgcgt gaacatgatc atggcagaat caccaggcct catcaccatt       60

gccttttagg atatctactc agtgctgaat gtacagtttt tcttgatcat gaaaacgcca      120

acaaaattct gaatcggcca aagaggtata attcaggtaa attggaagag tttgttcaag      180

ggaaccttga gagagaatgt atggaagaaa agtgtagttt tgaagaagca cgagaagttt      240

ttgaaaacac tgaaagaaca actgaatttt ggaagcagta tgttgatgga gatcagtgtg      300

agtccaatcc atgtttaaat ggcggcagtt gcaaggatga cattaattcc tatgaatgtt      360

ggtgtccctt tggatttgaa ggaaagaact gtgaattaga tgtaacatgt aacattaaga      420

atggcagatg cgagcagttt tgtaaaaata gtgctgataa caaggtggtt tgctcctgta      480

ctgagggata tcgacttgca gaaaaccaga agtcctgtga accagcagtg ccatttccat      540

gtggaagagt ttctgtttca caaacttcta agctcacccg tgctgagact gtttttcctg      600

atgtggacta tgtaaattct actgaagctg aaaccatttt ggataacatc actcaaagca      660

cccaatcatt taatgacttc actcgagttg ttggtggaga agatgccaaa ccaggtcaat      720

tcccttggca ggttgttttg aatggtaaag ttgatgcatt ctgtggaggc tctatcgtta      780

atgaaaaatg gattgtaact gctgcccact gtgttgaaac tggtgttaaa attacagttg      840

tcgcaggtga acataatatt gaggagacag aacatacaga gcaaaagcga aatgtgattc      900

gaattattcc tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc      960

ttctggaact ggacgaaccc ttagtgctaa acagctacgt tacacctatt tgcattgctg     1020

acaaggaata cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt ggctggggaa     1080

gagtcttcca caaagggaga tcagctttag ttctccagta ccttagagtt ccacttgttg     1140

accgagccac atgtcttcga tctacaaagt tcaccatcta taacaacatg ttctgtgctg     1200

gcttccatga aggaggtaga gattcatgtc aaggagatag tgggggaccc catgttactg     1260

aagtggaagg gaccagtttc ttaactggaa ttattagctg gggtgaagag tgtgcaatga     1320

aaggcaaata tggaatatat accaaggtat cccggtatgt caactggatt aaggaaaaaa     1380

caaagctcac ttgaacgcgg ccgc                                            1404


<210>  17
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  18
<211>  1502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  18
gcgatcgcca tgcagcgcgt gaacatgatc atggcagaat caccaggcct catcaccatc       60

tgccttttag gatatctact cagtgctgaa tgtacagttt ttcttgatca tgaaaacgcc      120

aacaaaattc tgaatcggcc aaagaggtat aattcaggta aattggaaga gtttgttcaa      180

gggaaccttg agagagaatg tatggaagaa aagtgtagtt ttgaagaagc acgagaagtt      240

tttgaaaaca ctgaaagaac aactgaattt tggaagcagt atgttgatgg agatcagtgt      300

gagtccaatc catgtttaaa tggcggcagt tgcaaggatg acattaattc ctatgaatgt      360

tggtgtccct ttggatttga aggaaagaac tgtgaattag atgtaacatg taacattaag      420

aatggcagat gcgagcagtt ttgtaaaaat agtgctgata acaaggtggt ttgctcctgt      480

actgagggat atcgacttgc agaaaaccag aagtcctgtg aaccagcagt gccatttcca      540

tgtggaagag tttctgtttc acaaacttct aagctcaccc gtgctgagac tgtttttcct      600

gatgtggact atgtaaattc tactgaagct gaaaccattt tggataacat cactcaaagc      660

acccaatcat ttaatgactt cactcgagtt gttggtggag aagatgccaa accaggtcaa      720

ttcccttggc aggttgtttt gaatggtaaa gttgatgcat tctgtggagg ctctatcgtt      780

aatgaaaaat ggattgtaac tgctgcccac tgtgttgaaa ctggtgttaa aattacagtt      840

gtcgcaggtg aacataatat tgaggagaca gaacatacag agcaaaagcg aaatgtgatt      900

cgaattattc ctcaccacaa ctacaatgca gctattaata agtacaacca tgacattgcc      960

cttctggaac tggacgaacc cttagtgcta aacagctacg ttacacctat ttgcattgct     1020

gacaaggaat acacgaacat cttcctcaaa tttggatctg gctatgtaag tggctgggga     1080

agagtcttcc acaaagggag atcagcttta gttcttcagt accttagagt tccacttgtt     1140

gaccgagcca catgtcttcg atctacaaag ttcaccatct ataacaacat gttctgtgct     1200

ggcttccatg aaggaggtag agattcatgt caaggagata gtgggggacc ccatgttact     1260

gaagtggaag ggaccagttt cttaactgga attattagct ggggtgaaga gtgtgcaatg     1320

aaaggcaaat atggaatata taccaaggta tcccggtatg tcaactggat taaggaaaaa     1380

acaaagctca ctagctccag cagcaaggcc cctcccccga gcctgccctc cccaagcagg     1440

ctgcctgggc cctccgacac accaatcctg ccacagtgat gaaggtctgg atccgcggcc     1500

gc                                                                    1502


<210>  19
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  19

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Ser Ser Ser 
    450                 455                 460                 


Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Asp Thr Pro Ile Leu Pro Gln 
                485                 


<210>  20
<211>  1585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  20
gcgatcgcca tgcagcgcgt gaacatgatc atggcagaat caccaggcct catcaccatc       60

tgccttttag gatatctact cagtgctgaa tgtacagttt ttcttgatca tgaaaacgcc      120

aacaaaattc tgaatcggcc aaagaggtat aattcaggta aattggaaga gtttgttcaa      180

gggaaccttg agagagaatg tatggaagaa aagtgtagtt ttgaagaagc acgagaagtt      240

tttgaaaaca ctgaaagaac aactgaattt tggaagcagt atgttgatgg agatcagtgt      300

gagtccaatc catgtttaaa tggcggcagt tgcaaggatg acattaattc ctatgaatgt      360

tggtgtccct ttggatttga aggaaagaac tgtgaattag atgtaacatg taacattaag      420

aatggcagat gcgagcagtt ttgtaaaaat agtgctgata acaaggtggt ttgctcctgt      480

actgagggat atcgacttgc agaaaaccag aagtcctgtg aaccagcagt gccatttcca      540

tgtggaagag tttctgtttc acaaacttct aagctcaccc gtgctgagac tgtttttcct      600

gatgtggact atgtaaattc tactgaagct gaaaccattt tggataacat cactcaaagc      660

acccaatcat ttaatgactt cactcgagtt gttggtggag aagatgccaa accaggtcaa      720

ttcccttggc aggttgtttt gaatggtaaa gttgatgcat tctgtggagg ctctatcgtt      780

aatgaaaaat ggattgtaac tgctgcccac tgtgttgaaa ctggtgttaa aattacagtt      840

gtcgcaggtg aacataatat tgaggagaca gaacatacag agcaaaagcg aaatgtgatt      900

cgaattattc ctcaccacaa ctacaatgca gctattaata agtacaacca tgacattgcc      960

cttctggaac tggacgaacc cttagtgcta aacagctacg ttacacctat ttgcattgct     1020

acaaggaata cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt ggctggggaa     1080

gagtcttcca caaagggaga tcagctttag ttcttcagta ccttagagtt ccacttgttg     1140

accgagccac atgtcttcga tctacaaagt tcaccatcta taacaacatg ttctgtgctg     1200

gcttccatga aggaggtaga gattcatgtc aaggagatag tgggggaccc catgttactg     1260

aagtggaagg gaccagtttc ttaactggaa ttattagctg gggtgaagag tgtgcaatga     1320

aaggcaaata tggaatatat accaaggtat cccggtatgt caactggatt aaggaaaaaa     1380

caaagctcac tagctccagc agcaaggccc ctcccccgag cctgccctcc ccaagcaggc     1440

tgcctgggcc ctccgacaca ccaatcctgc cacagagcag ctcctctaag gcccctcctc     1500

catccctgcc atccccctcc cggctgcctg gcccctctga cacccctatc ctgcctcagt     1560

gatgaaggtc tggatccgcg gccgc                                           1585


<210>  21
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  21

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Ser Ser Ser 
    450                 455                 460                 


Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro 
                485                 490                 495     


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
            500                 505                 510         


Pro Ile Leu Pro Gln 
        515         


<210>  22
<211>  2413
<212>  DNA
<213>  Homo sapiens

<400>  22
tctagagtcg accccgccat ggagctgagg ccctggttgc tatgggtggt agcagcaaca       60

ggaaccttgg tcctgctagc agctgatgct cagggccaga aggtcttcac caacacgtgg      120

gctgtgcgca tccctggagg cccagcggtg gccaacagtg tggcacggaa gcatgggttc      180

ctcaacctgg gccagatctt cggggactat taccacttct ggcatcgagg agtgacgaag      240

cggtccctgt cgcctcaccg cccgcggcac agccggctgc agagggagcc tcaagtacag      300

tggctggaac agcaggtggc aaagcgacgg actaaacggg acgtgtacca ggagcccaca      360

gaccccaagt ttcctcagca gtggtacctg tctggtgtca ctcagcggga cctgaatgtg      420

aaggcggcct gggcgcaggg ctacacaggg cacggcattg tggtctccat tctggacgat      480

ggcatcgaga agaaccaccc ggacttggca ggcaattatg atcctggggc cagttttgat      540

gtcaatgacc aggaccctga cccccagcct cggtacacac agatgaatga caacaggcac      600

ggcacacggt gtgcggggga agtggctgcg gtggccaaca acggtgtctg tggtgtaggt      660

gtggcctaca acgcccgcat tggaggggtg cgcatgctgg atggcgaggt gacagatgca      720

gtggaggcac gctcgctggg cctgaacccc aaccacatcc acatctacag tgccagctgg      780

ggccccgagg atgacggcaa gacagtggat gggccagccc gcctcgccga ggaggccttc      840

ttccgtgggg ttagccaggg ccgagggggg ctgggctcca tctttgtctg ggcctcgggg      900

aacgggggcc gggaacatga cagctgcaac tgcgacggct acaccaacag tatctacacg      960

ctgtccatca gcagcgccac gcagtttggc aacgtgccgt ggtacagcga ggcctgctcg     1020

tccacactgg ccacgaccta cagcagtggc aaccagaatg agaagcagat cgtgacgact     1080

gacttgcggc agaagtgcac ggagtctcac acgggcacct cagcctctgc ccccttagca     1140

gccggcatca ttgctctcac cctggaggcc aataagaacc tcacatggcg ggacatgcaa     1200

cacctggtgg tacagacctc gaagccagcc cacctcaatg ccaacgactg ggccaccaat     1260

ggtgtgggcc ggaaagtgag ccactcatat ggctacgggc ttttggacgc aggcgccatg     1320

gtggccctgg cccagaattg gaccacagtg gccccccagc ggaagtgcat catcgacatc     1380

ctcaccgagc ccaaagacat cgggaaacgg ctcgaggtgc ggaagaccgt gaccgcgtgc     1440

ctgggcgagc ccaaccacat cactcggctg gagcacgctc aggcgcggct caccctgtcc     1500

tataatcgcc gtggcgacct ggccatccac ctggtcagcc ccatgggcac ccgctccacc     1560

ctgctggcag ccaggccaca tgactactcc gcagatgggt ttaatgactg ggccttcatg     1620

acaactcatt cctgggatga ggatccctct ggcgagtggg tcctagagat tgaaaacacc     1680

agcgaagcca acaactatgg gacgctgacc aagttcaccc tcgtactcta tggcaccgcc     1740

cctgaggggc tgcccgtacc tccagaaagc agtggctgca agaccctcac gtccagtcag     1800

gcctgtgtgg tgtgcgagga aggcttctcc ctgcaccaga agagctgtgt ccagcactgc     1860

cctccaggct tcgcccccca agtcctcgat acgcactata gcaccgagaa tgacgtggag     1920

accatccggg ccagcgtctg cgccccctgc cacgcctcat gtgccacatg ccaggggccg     1980

gccctgacag actgcctcag ctgccccagc cacgcctcct tggaccctgt ggagcagact     2040

tgctcccggc aaagccagag cagccgagag tccccgccac agcagcagcc acctcggctg     2100

cccccggagg tggaggcggg gcaacggctg cgggcagggc tgctgccctc acacctgcct     2160

gaggtggtgg ccggcctcag ctgcgccttc atcgtgctgg tcttcgtcac tgtcttcctg     2220

gtcctgcagc tgcgctctgg ctttagtttt cggggggtga aggtgtacac catggaccgt     2280

ggcctcatct cctacaaggg gctgccccct gaagcctggc aggaggagtg cccgtctgac     2340

tcagaagagg acgagggccg gggcgagagg accgccttta tcaaagacca gagcgccctc     2400

tgaacgcggc cgc                                                        2413


<210>  23
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  24
<211>  1621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  24
ctcgaggaca tggtctccca ggccctcagg ctcctctgcc ttctgcttgg gcttcagggc       60

tgcctggctg cagtcttcgt aacccaggag gaagcccacg gcgtcctgca ccggcgccgg      120

cgcgccaacg cgttcctgga ggagctgcgg ccgggctccc tggagaggga gtgcaaggag      180

gagcagtgct ccttcgagga ggcccgggag atcttcaagg acgcggagag gacgaagctg      240

ttctggattt cttacagtga tggggaccag tgtgcctcaa gtccatgcca gaatgggggc      300

tcctgcaagg accagctcca gtcctatatc tgcttctgcc tccctgcctt cgagggccgg      360

aactgtgaga cgcacaagga tgaccagctg atctgtgtga acgagaacgg cggctgtgag      420

cagtactgca gtgaccacac gggcaccaag cgctcctgtc ggtgccacga ggggtactct      480

ctgctggcag acggggtgtc ctgcacaccc acagttgaat atccatgtgg aaaaatacct      540

attctagaaa aaagaaatgc cagcaaaccc caaggccgaa ttgtgggggg caaggtgtgc      600

cccaaagggg agtgtccatg gcaggtcctg ttgttggtga atggagctca gttgtgtggg      660

gggaccctga tcaacaccat ctgggtggtc tccgcggccc actgtttcga caaaatcaag      720

aactggagga acctgatcgc ggtgctgggc gagcacgacc tcagcgagca cgacggggat      780

gagcagagcc ggcgggtggc gcaggtcatc atccccagca cgtacgtccc gggcaccacc      840

aaccacgaca tcgcgctgct ccgcctgcac cagcccgtgg tcctcactga ccatgtggtg      900

cccctctgcc tgcccgaacg gacgttctct gagaggacgc tggccttcgt gcgcttctca      960

ttggtcagcg gctggggcca gctgctggac cgtggcgcca cggccctgga gctcatggtc     1020

ctcaacgtgc cccggctgat gacccaggac tgcctgcagc agtcacggaa ggtgggagac     1080

tccccaaata tcacggagta catgttctgt gccggctact cggatggcag caaggactcc     1140

tgcaaggggg acagtggagg cccacatgcc acccactacc ggggcacgtg gtacctgacc     1200

ggcatcgtga gctggggcca gggctgcgcc accgtgggcc acttcggcgt gtacaccagg     1260

gtgtcccagt acatcgagtg gctgcagaaa ctgatgagaa gcgagcccag acccggcgtg     1320

ctgctgagag cccccttccc cagcagcagc tccaaggccc ctccccctag cctgcccagc     1380

cctagcagac tgcctgggcc cagtgacacc cctatcctgc ctcagtccag ctccagcaag     1440

gccccacccc ctagcctgcc ttctccttct cggctgcctg gccccagcga tactccaatt     1500

ctgccccagt cctccagcag taaggctccc cctccatctc tgccatcccc cagcagactg     1560

ccaggccctt ctgatacacc catcctccca cagtgatgag gatccgcggc cgcttaatta     1620

a                                                                     1621


<210>  25
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  25

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Ser Ser Ser Ser 
        435                 440                 445             


Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro 
    450                 455                 460                 


Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro 
465                 470                 475                 480 


Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro 
                485                 490                 495     


Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro 
            500                 505                 510         


Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
        515                 520                 525             


<210>  26
<211>  1607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  26
ctcgaggaca tggtctccca ggccctcagg ctcctctgcc ttctgcttgg gcttcagggc       60

tgcctggctg cagtcttcgt aacccaggag gaagcccacg gcgtcctgca ccggcgccgg      120

cgcgccaacg cgttcctgga ggagctgcgg ccgggctccc tggagaggga gtgcaaggag      180

gagcagtgct ccttcgagga ggcccgggag atcttcaagg acgcggagag gacgaagctg      240

ttctggattt cttacagtga tggggaccag tgtgcctcaa gtccatgcca gaatgggggc      300

tcctgcaagg accagctcca gtcctatatc tgcttctgcc tccctgcctt cgagggccgg      360

aactgtgaga cgcacaagga tgaccagctg atctgtgtga acgagaacgg cggctgtgag      420

cagtactgca gtgaccacac gggcaccaag cgctcctgtc ggtgccacga ggggtactct      480

ctgctggcag acggggtgtc ctgcacaccc acagttgaat atccatgtgg aaaaatacct      540

attctagaaa aaagaaatgc cagcaaaccc caaggccgaa ttgtgggggg caaggtgtgc      600

cccaaagggg agtgtccatg gcaggtcctg ttgttggtga atggagctca gttgtgtggg      660

gggaccctga tcaacaccat ctgggtggtc tccgcggccc actgtttcga caaaatcaag      720

aactggagga acctgatcgc ggtgctgggc gagcacgacc tcagcgagca cgacggggat      780

gagcagagcc ggcgggtggc gcaggtcatc atccccagca cgtacgtccc gggcaccacc      840

aaccacgaca tcgcgctgct ccgcctgcac cagcccgtgg tcctcactga ccatgtggtg      900

cccctctgcc tgcccgaacg gacgttctct gagaggacgc tggccttcgt gcgcttctca      960

ttggtcagcg gctggggcca gctgctggac cgtggcgcca cggccctgga gctcatggtc     1020

ctcaacgtgc cccggctgat gacccaggac tgcctgcagc agtcacggaa ggtgggagac     1080

tccccaaata tcacggagta catgttctgt gccggctact cggatggcag caaggactcc     1140

tgcaaggggg acagtggagg cccacatgcc acccactacc ggggcacgtg gtacctgacc     1200

ggcatcgtga gctggggcca gggctgcgcc accgtgggcc acttcggcgt gtacaccagg     1260

gtgtcccagt acatcgagtg gctgcagaaa ctgatgagaa gcgagcccag acccggcgtg     1320

ctgctgagag cccccttccc cagcagcagc tccaaggccc ctccccctag cctgcccagc     1380

cctagcagac tgcctgggcc cagtgacacc cctatcctgc ctcagtccag ctccagcaag     1440

gccccacccc ctagcctgcc ttctccttct cggctgcctg gccccagcga tactccaatt     1500

ctgccccagt cctccagcag taaggctccc cctccatctc tgccatcccc cagcagactg     1560

ccaggccctt ctgatacacc catcctccca cagtgatgag gatccgc                   1607


<210>  27
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  27

Leu Glu Asp Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu 
1               5                   10                  15      


Gly Leu Gln Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala 
            20                  25                  30          


His Gly Val Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu 
        35                  40                  45              


Leu Arg Pro Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser 
    50                  55                  60                  


Phe Glu Glu Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu 
65                  70                  75                  80  


Phe Trp Ile Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys 
                85                  90                  95      


Gln Asn Gly Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe 
            100                 105                 110         


Cys Leu Pro Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp 
        115                 120                 125             


Gln Leu Ile Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser 
    130                 135                 140                 


Asp His Thr Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser 
145                 150                 155                 160 


Leu Leu Ala Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys 
                165                 170                 175     


Gly Lys Ile Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly 
            180                 185                 190         


Arg Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln 
        195                 200                 205             


Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile 
    210                 215                 220                 


Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys 
225                 230                 235                 240 


Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu 
                245                 250                 255     


His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro 
            260                 265                 270         


Ser Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg 
        275                 280                 285             


Leu His Gln Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu 
    290                 295                 300                 


Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser 
305                 310                 315                 320 


Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu 
                325                 330                 335     


Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu 
            340                 345                 350         


Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met 
        355                 360                 365             


Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp 
    370                 375                 380                 


Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr 
385                 390                 395                 400 


Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly 
                405                 410                 415     


Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met 
            420                 425                 430         


Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Ser 
        435                 440                 445             


Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu 
    450                 455                 460                 


Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys 
465                 470                 475                 480 


Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser 
                485                 490                 495     


Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro 
            500                 505                 510         


Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile 
        515                 520                 525             


Leu Pro Gln Gly 
    530         


<210>  28
<211>  1775
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  28
ctcgaggaca tggtctccca ggccctcagg ctcctctgcc ttctgcttgg gcttcagggc       60

tgcctggctg cagtcttcgt aacccaggag gaagcccacg gcgtcctgca ccggcgccgg      120

cgcgccaacg cgttcctgga ggagctgcgg ccgggctccc tggagaggga gtgcaaggag      180

gagcagtgct ccttcgagga ggcccgggag atcttcaagg acgcggagag gacgaagctg      240

ttctggattt cttacagtga tggggaccag tgtgcctcaa gtccatgcca gaatgggggc      300

tcctgcaagg accagctcca gtcctatatc tgcttctgcc tccctgcctt cgagggccgg      360

aactgtgaga cgcacaagga tgaccagctg atctgtgtga acgagaacgg cggctgtgag      420

cagtactgca gtgaccacac gggcaccaag cgctcctgtc ggtgccacga ggggtactct      480

ctgctggcag acggggtgtc ctgcacaccc acagttgaat atccatgtgg aaaaatacct      540

attctagaaa aaagaaatgc cagcaaaccc caaggccgaa ttgtgggggg caaggtgtgc      600

cccaaagggg agtgtccatg gcaggtcctg ttgttggtga atggagctca gttgtgtggg      660

gggaccctga tcaacaccat ctgggtggtc tccgcggccc actgtttcga caaaatcaag      720

aactggagga acctgatcgc ggtgctgggc gagcacgacc tcagcgagca cgacggggat      780

gagcagagcc ggcgggtggc gcaggtcatc atccccagca cgtacgtccc gggcaccacc      840

aaccacgaca tcgcgctgct ccgcctgcac cagcccgtgg tcctcactga ccatgtggtg      900

cccctctgcc tgcccgaacg gacgttctct gagaggacgc tggccttcgt gcgcttctca      960

ttggtcagcg gctggggcca gctgctggac cgtggcgcca cggccctgga gctcatggtc     1020

ctcaacgtgc cccggctgat gacccaggac tgcctgcagc agtcacggaa ggtgggagac     1080

tccccaaata tcacggagta catgttctgt gccggctact cggatggcag caaggactcc     1140

tgcaaggggg acagtggagg cccacatgcc acccactacc ggggcacgtg gtacctgacc     1200

ggcatcgtga gctggggcca gggctgcgcc accgtgggcc acttcggcgt gtacaccagg     1260

gtgtcccagt acatcgagtg gctgcagaaa ctgatgagaa gcgagcccag acccggcgtg     1320

ctgctgagag cccccttccc cagcagcagc tccaaggccc ctccccctag cctgcccagc     1380

cctagcagac tgcctgggcc ctctgacacc cctatcctgc ctcagtccag ctcctctaag     1440

gctccaccac cttccctgcc tagcccttca agactgccag gccctagcga tacaccaatt     1500

ctgccccagt cctccagcag caaggctccc ccacctagcc tgccttctcc atcaaggctg     1560

cctggcccat ccgatacccc aattttgcct cagagcagct ctagcaaggc acctcccccc     1620

agtctgccct ctccaagcag actccctggc ccttcagaca ctccaatcct cccacagtcc     1680

tctagctcta aagctccacc tcccagcctg cccagcccta gtagactccc cggaccttct     1740

gataccccca tcttgcccca gtgatgagga tccgc                                1775


<210>  29
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor VII

<400>  29

Leu Glu Asp Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu 
1               5                   10                  15      


Gly Leu Gln Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala 
            20                  25                  30          


His Gly Val Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu 
        35                  40                  45              


Leu Arg Pro Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser 
    50                  55                  60                  


Phe Glu Glu Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu 
65                  70                  75                  80  


Phe Trp Ile Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys 
                85                  90                  95      


Gln Asn Gly Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe 
            100                 105                 110         


Cys Leu Pro Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp 
        115                 120                 125             


Gln Leu Ile Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser 
    130                 135                 140                 


Asp His Thr Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser 
145                 150                 155                 160 


Leu Leu Ala Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys 
                165                 170                 175     


Gly Lys Ile Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly 
            180                 185                 190         


Arg Ile Val Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln 
        195                 200                 205             


Val Leu Leu Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile 
    210                 215                 220                 


Asn Thr Ile Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys 
225                 230                 235                 240 


Asn Trp Arg Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu 
                245                 250                 255     


His Asp Gly Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro 
            260                 265                 270         


Ser Thr Tyr Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg 
        275                 280                 285             


Leu His Gln Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu 
    290                 295                 300                 


Pro Glu Arg Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser 
305                 310                 315                 320 


Leu Val Ser Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu 
                325                 330                 335     


Glu Leu Met Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu 
            340                 345                 350         


Gln Gln Ser Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met 
        355                 360                 365             


Phe Cys Ala Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Lys Gly Asp 
    370                 375                 380                 


Ser Gly Gly Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr 
385                 390                 395                 400 


Gly Ile Val Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly 
                405                 410                 415     


Val Tyr Thr Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met 
            420                 425                 430         


Arg Ser Glu Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Ser 
        435                 440                 445             


Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu 
    450                 455                 460                 


Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys 
465                 470                 475                 480 


Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser 
                485                 490                 495     


Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro 
            500                 505                 510         


Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile 
        515                 520                 525             


Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser 
    530                 535                 540                 


Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser 
545                 550                 555                 560 


Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu 
                565                 570                 575     


Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly Ser 
            580                 585                 


<210>  30
<211>  1673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  30
tctagagtcg accccgccat gcagcgcgtg aacatgatca tggcagaatc accaggcctc       60

atcaccatct gccttttagg atatctactc agtgctgaat gtacagtttt tcttgatcat      120

gaaaacgcca acaaaattct gaatcggcca aagaggtata attcaggtaa attggaagag      180

tttgttcaag ggaaccttga gagagaatgt atggaagaaa agtgtagttt tgaagaagca      240

cgagaagttt ttgaaaacac tgaaagaaca actgaatttt ggaagcagta tgttgatgga      300

gatcagtgtg agtccaatcc atgtttaaat ggcggcagtt gcaaggatga cattaattcc      360

tatgaatgtt ggtgtccctt tggatttgaa ggaaagaact gtgaattaga tgtaacatgt      420

aacattaaga atggcagatg cgagcagttt tgtaaaaata gtgctgataa caaggtggtt      480

tgctcctgta ctgagggata tcgacttgca gaaaaccaga agtcctgtga accagcagtg      540

ccatttccat gtggaagagt ttctgtttca caaacttcta agctcacccg tgctgaggca      600

gtttttcctg atgtggacta tgtaaattct actgaagctg aaaccatttt ggataacatc      660

actcaaagca cccaatcatt taatgacttc actcgagttg ttggtggaga agatgccaaa      720

ccaggtcaat tcccttggca ggttgttttg aatggtaaag ttgatgcatt ctgtggaggc      780

tctatcgtta atgaaaaatg gattgtaact gctgcccact gtgttgaaac tggtgttaaa      840

attacagttg tcgcaggtga acataatatt gaggagacag aacatacaga gcaaaagcga      900

aatgtgattc gaattattcc tcaccacaac tacaatgcag ctattaataa gtacaaccat      960

gacattgccc ttctggaact ggacgaaccc ttagtgctaa acagctacgt tacacctatt     1020

tgcattgctg acaaggaata cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt     1080

ggctggggaa gagtcttcca caaagggaga tcagctttag ttcttcagta ccttagagtt     1140

ccacttgttg accgagccac atgtcttcga tctacaaagt tcaccatcta taacaacatg     1200

ttctgtgctg gcttccatga aggaggtaga gattcatgtc aaggagatag tgggggaccc     1260

catgttactg aagtggaagg gaccagtttc ttaactggaa ttattagctg gggtgaagag     1320

tgtgcaatga aaggcaaata tggaatatat accaaggtat cccggtatgt caactggatt     1380

aaggaaaaaa caaagctcac tagctccagc agcaaggccc ctcccccgag cctgccctcc     1440

ccaagcaggc tgcctgggcc cagtgacacc cctatcctgc ctcagtccag ctccagcaag     1500

gccccacccc ctagcctgcc ttctccttct cggctgcctg gccccagcga tactccaatt     1560

ctgccccagt cctccagcag taaggctccc cctccatctc tgccatcccc cagcagactg     1620

ccaggccctt ctgatacacc catcctccca cagtgatgag gatccgcggc cgc            1673


<210>  31
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  31

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr Ser Ser Ser 
    450                 455                 460                 


Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly 
465                 470                 475                 480 


Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro 
                485                 490                 495     


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
            500                 505                 510         


Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu 
        515                 520                 525             


Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro 
    530                 535                 540                 


Gln 
545 


<210>  32
<211>  1757
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  32
tctagagtcg accccgccat gcagcgcgtg aacatgatca tggcagaatc accaggcctc       60

atcaccatct gccttttagg atatctactc agtgctgaat gtacagtttt tcttgatcat      120

gaaaacgcca acaaaattct gaatcggcca aagaggtata attcaggtaa attggaagag      180

tttgttcaag ggaaccttga gagagaatgt atggaagaaa agtgtagttt tgaagaagca      240

cgagaagttt ttgaaaacac tgaaagaaca actgaatttt ggaagcagta tgttgatgga      300

gatcagtgtg agtccaatcc atgtttaaat ggcggcagtt gcaaggatga cattaattcc      360

tatgaatgtt ggtgtccctt tggatttgaa ggaaagaact gtgaattaga tgtaacatgt      420

aacattaaga atggcagatg cgagcagttt tgtaaaaata gtgctgataa caaggtggtt      480

tgctcctgta ctgagggata tcgacttgca gaaaaccaga agtcctgtga accagcagtg      540

ccatttccat gtggaagagt ttctgtttca caaacttcta agctcacccg tgctgaggca      600

gtttttcctg atgtggacta tgtaaattct actgaagctg aaaccatttt ggataacatc      660

actcaaagca cccaatcatt taatgacttc actcgagttg ttggtggaga agatgccaaa      720

ccaggtcaat tcccttggca ggttgttttg aatggtaaag ttgatgcatt ctgtggaggc      780

tctatcgtta atgaaaaatg gattgtaact gctgcccact gtgttgaaac tggtgttaaa      840

attacagttg tcgcaggtga acataatatt gaggagacag aacatacaga gcaaaagcga      900

aatgtgattc gaattattcc tcaccacaac tacaatgcag ctattaataa gtacaaccat      960

gacattgccc ttctggaact ggacgaaccc ttagtgctaa acagctacgt tacacctatt     1020

tgcattgctg acaaggaata cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt     1080

ggctggggaa gagtcttcca caaagggaga tcagctttag ttcttcagta ccttagagtt     1140

ccacttgttg accgagccac atgtcttcga tctacaaagt tcaccatcta taacaacatg     1200

ttctgtgctg gcttccatga aggaggtaga gattcatgtc aaggagatag tgggggaccc     1260

catgttactg aagtggaagg gaccagtttc ttaactggaa ttattagctg gggtgaagag     1320

tgtgcaatga aaggcaaata tggaatatat accaaggtat cccggtatgt caactggatt     1380

aaggaaaaaa caaagctcac tagctccagc agcaaggccc ctcccccgag cctgccctcc     1440

ccaagcaggc tgcctgggcc ctctgacacc cctatcctgc ctcagtccag ctcctctaag     1500

gccccaccac cttccctgcc tagcccttca agactgccag gccctagcga tacaccaatt     1560

ctgccccagt cctccagcag caaggctccc ccacctagcc tgccttctcc atcaaggctg     1620

cctggcccat ccgatacccc aattttgcct cagagcagct ctagcaaggc acctcccccc     1680

agtctgccct ctccaagcag actccctggc ccttcagaca ctcccattct gccacagtga     1740

tgaggatccg cggccgc                                                    1757


<210>  33
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  33

Ser Arg Val Asp Pro Ala Met Gln Arg Val Asn Met Ile Met Ala Glu 
1               5                   10                  15      


Ser Pro Gly Leu Ile Thr Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala 
            20                  25                  30          


Glu Cys Thr Val Phe Leu Asp His Glu Asn Ala Asn Lys Ile Leu Asn 
        35                  40                  45              


Arg Pro Lys Arg Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly 
    50                  55                  60                  


Asn Leu Glu Arg Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala 
65                  70                  75                  80  


Arg Glu Val Phe Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln 
                85                  90                  95      


Tyr Val Asp Gly Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly 
            100                 105                 110         


Ser Cys Lys Asp Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly 
        115                 120                 125             


Phe Glu Gly Lys Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn 
    130                 135                 140                 


Gly Arg Cys Glu Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val 
145                 150                 155                 160 


Cys Ser Cys Thr Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys 
                165                 170                 175     


Glu Pro Ala Val Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr 
            180                 185                 190         


Ser Lys Leu Thr Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val 
        195                 200                 205             


Asn Ser Thr Glu Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr 
    210                 215                 220                 


Gln Ser Phe Asn Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys 
225                 230                 235                 240 


Pro Gly Gln Phe Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala 
                245                 250                 255     


Phe Cys Gly Gly Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala 
            260                 265                 270         


His Cys Val Glu Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His 
        275                 280                 285             


Asn Ile Glu Glu Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg 
    290                 295                 300                 


Ile Ile Pro His His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His 
305                 310                 315                 320 


Asp Ile Ala Leu Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr 
                325                 330                 335     


Val Thr Pro Ile Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu 
            340                 345                 350         


Lys Phe Gly Ser Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys 
        355                 360                 365             


Gly Arg Ser Ala Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp 
    370                 375                 380                 


Arg Ala Thr Cys Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met 
385                 390                 395                 400 


Phe Cys Ala Gly Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp 
                405                 410                 415     


Ser Gly Gly Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr 
            420                 425                 430         


Gly Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly 
        435                 440                 445             


Ile Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr 
    450                 455                 460                 


Lys Leu Thr Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser 
465                 470                 475                 480 


Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser 
                485                 490                 495     


Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu 
            500                 505                 510         


Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys 
        515                 520                 525             


Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser 
    530                 535                 540                 


Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro 
545                 550                 555                 560 


Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile 
                565                 570                 575     


Leu Pro Gln Gly Ser Ala Ala 
            580             


<210>  34
<211>  1840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  34
ctagagtcga ccccgccatg cagcgcgtga acatgatcat ggcagaatca ccaggcctca       60

tcaccatctg ccttttagga tatctactca gtgctgaatg tacagttttt cttgatcatg      120

aaaacgccaa caaaattctg aatcggccaa agaggtataa ttcaggtaaa ttggaagagt      180

ttgttcaagg gaaccttgag agagaatgta tggaagaaaa gtgtagtttt gaagaagcac      240

gagaagtttt tgaaaacact gaaagaacaa ctgaattttg gaagcagtat gttgatggag      300

atcagtgtga gtccaatcca tgtttaaatg gcggcagttg caaggatgac attaattcct      360

atgaatgttg gtgtcccttt ggatttgaag gaaagaactg tgaattagat gtaacatgta      420

acattaagaa tggcagatgc gagcagtttt gtaaaaatag tgctgataac aaggtggttt      480

gctcctgtac tgagggatat cgacttgcag aaaaccagaa gtcctgtgaa ccagcagtgc      540

catttccatg tggaagagtt tctgtttcac aaacttctaa gctcacccgt gctgaggcag      600

tttttcctga tgtggactat gtaaattcta ctgaagctga aaccattttg gataacatca      660

ctcaaagcac ccaatcattt aatgacttca ctcgagttgt tggtggagaa gatgccaaac      720

caggtcaatt cccttggcag gttgttttga atggtaaagt tgatgcattc tgtggaggct      780

ctatcgttaa tgaaaaatgg attgtaactg ctgcccactg tgttgaaact ggtgttaaaa      840

ttacagttgt cgcaggtgaa cataatattg aggagacaga acatacagag caaaagcgaa      900

atgtgattcg aattattcct caccacaact acaatgcagc tattaataag tacaaccatg      960

acattgccct tctggaactg gacgaaccct tagtgctaaa cagctacgtt acacctattt     1020

gcattgctga caaggaatac acgaacatct tcctcaaatt tggatctggc tatgtaagtg     1080

gctggggaag agtcttccac aaagggagat cagctttagt tcttcagtac cttagagttc     1140

cacttgttga ccgagccaca tgtcttcgat ctacaaagtt caccatctat aacaacatgt     1200

tctgtgctgg cttccatgaa ggaggtagag attcatgtca aggagatagt gggggacccc     1260

atgttactga agtggaaggg accagtttct taactggaat tattagctgg ggtgaagagt     1320

gtgcaatgaa aggcaaatat ggaatatata ccaaggtatc ccggtatgtc aactggatta     1380

aggaaaaaac aaagctcact agctccagca gcaaggcccc tcccccgagc ctgccctccc     1440

caagcaggct gcctgggccc tctgacaccc ctatcctgcc tcagtccagc tcctctaagg     1500

ctccaccacc ttccctgcct agcccttcaa gactgccagg ccctagcgat acaccaattc     1560

tgccccagtc ctccagcagc aaggctcccc cacctagcct gccttctcca tcaaggctgc     1620

ctggcccatc cgatacccca attttgcctc agagcagctc tagcaaggca cctcccccca     1680

gtctgccctc tccaagcaga ctccctggcc cttcagacac tccaatcctc ccacagtcct     1740

ctagctctaa agctccacct cccagcctgc ccagccctag tagactcccc ggaccttctg     1800

atacccccat cttgccccag tgatgaggat ccgcggccgc                           1840


<210>  35
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTP-modified Factor IX

<400>  35

Arg Val Asp Pro Ala Met Gln Arg Val Asn Met Ile Met Ala Glu Ser 
1               5                   10                  15      


Pro Gly Leu Ile Thr Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu 
            20                  25                  30          


Cys Thr Val Phe Leu Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg 
        35                  40                  45              


Pro Lys Arg Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn 
    50                  55                  60                  


Leu Glu Arg Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg 
65                  70                  75                  80  


Glu Val Phe Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr 
                85                  90                  95      


Val Asp Gly Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser 
            100                 105                 110         


Cys Lys Asp Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe 
        115                 120                 125             


Glu Gly Lys Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly 
    130                 135                 140                 


Arg Cys Glu Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys 
145                 150                 155                 160 


Ser Cys Thr Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu 
                165                 170                 175     


Pro Ala Val Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser 
            180                 185                 190         


Lys Leu Thr Arg Ala Glu Ala Val Phe Pro Asp Val Asp Tyr Val Asn 
        195                 200                 205             


Ser Thr Glu Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln 
    210                 215                 220                 


Ser Phe Asn Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro 
225                 230                 235                 240 


Gly Gln Phe Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe 
                245                 250                 255     


Cys Gly Gly Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His 
            260                 265                 270         


Cys Val Glu Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn 
        275                 280                 285             


Ile Glu Glu Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile 
    290                 295                 300                 


Ile Pro His His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp 
305                 310                 315                 320 


Ile Ala Leu Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val 
                325                 330                 335     


Thr Pro Ile Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys 
            340                 345                 350         


Phe Gly Ser Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly 
        355                 360                 365             


Arg Ser Ala Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg 
    370                 375                 380                 


Ala Thr Cys Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe 
385                 390                 395                 400 


Cys Ala Gly Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser 
                405                 410                 415     


Gly Gly Pro His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly 
            420                 425                 430         


Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile 
        435                 440                 445             


Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys 
    450                 455                 460                 


Leu Thr Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro 
465                 470                 475                 480 


Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser 
                485                 490                 495     


Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro 
            500                 505                 510         


Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala 
        515                 520                 525             


Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp 
    530                 535                 540                 


Thr Pro Ile Leu Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser 
545                 550                 555                 560 


Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu 
                565                 570                 575     


Pro Gln Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro 
            580                 585                 590         


Ser Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Gly Ser 
        595                 600                 605             


Ala Ala 
    610 


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 101 for FIX-(CTP)2

<400>  36
gtttagtgaa ccgtcagaat                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 103-R for FIX-(CTP)2

<400>  37
ttgaggaaga tgttcgtgta                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 98 for FIX-(CTP)2

<400>  38
attacagttg tcgcaggtga                                                   20


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 99-Rfor FIX-(CTP)2

<400>  39
gctggagcta gtgagctttg ttttttcctt                                        30


<210>  40
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 100 for FIX-(CTP)2

<400>  40
gctcactagc tccagcagca aggcc                                             25


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 27-R for FIX-(CTP)2

<400>  41
ttttcactgc attctagttg tgg                                               23


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 75

<400>  42
ctcccagttc aattacagct                                                   20


<210>  43
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 122r

<400>  43
ggaaaaactg cctcagcacg ggtgagc                                           27


<210>  44
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 123

<400>  44
gtgctgaggc agtttttcct gatgtggact at                                     32


<210>  45
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 124r

<400>  45
caacacagtg ggcagcag                                                     18


