                         SEQUENCE LISTING

<110>  aTyr Pharma Inc.
 
<120>  HISTIDYL TRNA SYNTHETASES FOR TREATING AUTOIMMUNE AND 
       INFLAMMATORY DISEASES

<130>  ATYR-110/03WO 315789-2415

<150>  US 61/725,414
<151>  2012-11-12

<150>  US 61/655,358
<151>  2012-06-04

<150>  US 61/599,802
<151>  2012-02-16

<160>  236   

<170>  PatentIn version 3.5

<210>  1
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  2
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met 
    130                 135                 140     


<210>  3
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu 
                405             


<210>  4
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu 
    


<210>  5
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  6
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Gly Tyr Pro Trp Trp Asn Ser Cys Ser Arg Ile Leu 
                245                 250                 255     


Asn Tyr Pro Lys Thr Ser Arg Pro Trp Arg Ala Trp Glu Thr 
            260                 265                 270 


<210>  7
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu 
1               5                   10                  15      


Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile 
            20                  25                  30          


Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu 
        35                  40                  45              


Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu 
    50                  55                  60                  


Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg 
65                  70                  75                  80  


Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg 
                85                  90                  95      


Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            100                 105 


<210>  8
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Asp Phe Asp Ile 
    50                  55                  60                  


Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile 
65                  70                  75                  80  


Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val Lys 
                85                  90                  95      


Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val 
            100                 105                 110         


Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp 
        115                 120                 125             


Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly 
    130                 135                 140                 


Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His 
145                 150                 155                 160 


Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser 
                165                 170                 175     


Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe 
            180                 185                 190         


Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu 
        195                 200                 205             


Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala 
    210                 215                 220                 


Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val 
225                 230                 235                 240 


Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe 
                245                 250                 255     


Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val 
            260                 265                 270         


Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu 
        275                 280                 285             


Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys 
    290                 295                 300                 


Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala 
305                 310                 315                 320 


Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn 
                325                 330                 335     


Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile 
            340                 345                 350         


Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr 
        355                 360                 365             


Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile 
    370                 375                 380                 


Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
385                 390                 395 


<210>  9
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Val Asn Asp Arg 
    50                  55                  60                  


Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys 
65                  70                  75                  80  


Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp 
                85                  90                  95      


Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu 
            100                 105                 110         


Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser 
        115                 120                 125             


Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln 
    130                 135                 140                 


Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr 
145                 150                 155                 160 


Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg 
                165                 170                 175     


Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln 
            180                 185                 190         


Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala 
        195                 200                 205             


Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly 
    210                 215                 220                 


Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe 
225                 230                 235                 240 


Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr 
                245                 250                 255     


Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu 
            260                 265                 270         


Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala 
        275                 280                 285             


Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr 
    290                 295                 300                 


Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu 
305                 310                 315                 320 


Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu 
                325                 330                 335     


Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr 
            340                 345                 350         


Gly Gln Pro Leu Cys Ile Cys 
        355                 


<210>  10
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala 
            100                 105                 110         


Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val 
        115                 120                 125             


Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val 
    130                 135                 140                 


Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr 
145                 150                 155                 160 


Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp 
                165                 170                 175     


Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu 
            180                 185                 190         


Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile 
        195                 200                 205             


Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val 
    210                 215                 220                 


Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu 
225                 230                 235                 240 


Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu 
                245                 250                 255     


Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu 
            260                 265                 270         


Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu 
        275                 280                 285             


Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala 
    290                 295                 300                 


Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu 
305                 310                 315                 320 


Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro 
                325                 330                 335     


Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu 
            340                 345                 350         


Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu 
        355                 360                 365             


Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu 
    370                 375                 380                 


Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
385                 390                 395                 


<210>  11
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Val Asn 
                165                 170                 175     


Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp 
            180                 185                 190         


Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val 
        195                 200                 205             


Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala 
    210                 215                 220                 


Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly 
225                 230                 235                 240 


Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn 
                245                 250                 255     


Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr 
            260                 265                 270         


Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu 
        275                 280                 285             


Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu 
    290                 295                 300                 


Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser 
305                 310                 315                 320 


Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro 
                325                 330                 335     


Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg 
            340                 345                 350         


Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile 
        355                 360                 365             


Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu 
    370                 375                 380                 


Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile 
385                 390                 395                 400 


Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu 
                405                 410                 415     


Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu 
            420                 425                 430         


Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg 
        435                 440                 445             


Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg 
    450                 455                 460                 


Arg Thr Gly Gln Pro Leu Cys Ile Cys 
465                 470             


<210>  12
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Glu Thr Leu Met 
    50                  55                  60                  


Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln 
65                  70                  75                  80  


Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala 
                85                  90                  95      


Arg Tyr Leu Ala Met Asn Lys Leu Thr Asn Ile Lys Arg Tyr His Ile 
            100                 105                 110         


Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr 
        115                 120                 125             


Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro 
    130                 135                 140                 


Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser 
145                 150                 155                 160 


Ser Leu Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile 
                165                 170                 175     


Leu Asp Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg 
            180                 185                 190         


Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu 
        195                 200                 205             


Val Lys Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala 
    210                 215                 220                 


Asp Arg Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val 
225                 230                 235                 240 


Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu 
                245                 250                 255     


Glu Gly Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe 
            260                 265                 270         


Gly Ile Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu 
        275                 280                 285             


Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro 
    290                 295                 300                 


Ala Gln Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly 
305                 310                 315                 320 


Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys 
                325                 330                 335     


Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile 
            340                 345                 350         


Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu 
        355                 360                 365             


Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg 
    370                 375                 380                 


Leu Lys Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu 
385                 390                 395                 400 


Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu 
                405                 410                 415     


Glu Ala Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys 
            420                 425                 430         


Asp Gly Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp 
        435                 440                 445             


Val Arg Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln 
    450                 455                 460                 


Pro Leu Cys Ile Cys 
465                 


<210>  13
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile 
            100                 105                 110         


Pro Asp Ala Glu Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu 
        115                 120                 125             


Gln Ile Gly Asp Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp 
    130                 135                 140                 


Gly Met Phe Ala Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile 
145                 150                 155                 160 


Cys Ser Ser Val Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys 
                165                 170                 175     


Asn Glu Met Val Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg 
            180                 185                 190         


Ile Gly Asp Tyr Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln 
        195                 200                 205             


Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly 
    210                 215                 220                 


Leu Gly Asp Leu Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile 
225                 230                 235                 240 


Asp Asp Lys Ile Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr 
                245                 250                 255     


Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu Leu Gln Thr Pro Ala Gln 
            260                 265                 270         


Ala Gly Glu Glu Pro Leu Gly Val Gly Ser Val Ala Ala Gly Gly Arg 
        275                 280                 285             


Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys Gly Arg Lys Val Pro 
    290                 295                 300                 


Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile Val Glu 
305                 310                 315                 320 


Gln Arg Leu Glu Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln 
                325                 330                 335     


Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys 
            340                 345                 350         


Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr 
        355                 360                 365             


Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala 
    370                 375                 380                 


Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly 
385                 390                 395                 400 


Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg 
                405                 410                 415     


Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            420                 425                 430         


Cys Ile Cys 
        435 


<210>  14
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Ala Leu Glu Glu 
    50                  55                  60                  


Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys 
65                  70                  75                  80  


Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp Ala 
                85                  90                  95      


Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn 
            100                 105                 110         


Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile Ile 
        115                 120                 125             


Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val Thr 
    130                 135                 140                 


Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu Ile 
145                 150                 155                 160 


Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
                165                 170     


<210>  15
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Ala Leu Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln 
            100                 105                 110         


Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys 
        115                 120                 125             


Leu Val Ser Glu Leu Trp Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr 
    130                 135                 140                 


Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala 
145                 150                 155                 160 


Gly Ile Pro Leu Val Ala Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly 
                165                 170                 175     


Val Ile Lys Leu Arg Ser Val Thr Ser Arg Glu Glu Val Asp Val Arg 
            180                 185                 190         


Arg Glu Asp Leu Val Glu Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
        195                 200                 205             


Cys Ile Cys 
    210     


<210>  16
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
1               5                   10                  15      


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
            20                  25                  30          


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
        35                  40                  45              


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
    50                  55                  60                  


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
65                  70                  75                  80  


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
                85                  90                  95      


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
            100                 105                 110         


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
        115                 120                 125             


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
    130                 135                 140     


<210>  17
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Leu Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp 
1               5                   10                  15      


Phe Leu Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala 
            20                  25                  30          


Ile Cys Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val 
        35                  40                  45              


Asp Lys Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val 
    50                  55                  60                  


Gly Glu Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr 
65                  70                  75                  80  


Val Gln Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp 
                85                  90                  95      


Pro Lys Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu 
            100                 105                 110         


Lys Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile 
        115                 120                 125             


Ser Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly 
    130                 135                 140             


<210>  18
<211>  509
<212>  PRT
<213>  Mus musculus

<400>  18

Met Ala Asp Arg Ala Ala Leu Glu Glu Leu Val Arg Leu Gln Gly Ala 
1               5                   10                  15      


His Val Arg Gly Leu Lys Glu Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Thr Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Gln Asp 
        35                  40                  45              


Glu Gly Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asn Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Val Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Ile Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Met Pro Thr Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Ile Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Ser 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Trp Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Arg Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Ala Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Arg Arg Arg Thr Asn Gln Pro Leu Ser Thr Cys 
            500                 505                 


<210>  19
<211>  509
<212>  PRT
<213>  Canis lupus familiaris

<400>  19

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Arg Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Gly Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Ser Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Glu Ile Met Cys Glu Ile Leu Arg Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp His Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Ile Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Glu 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Val Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Thr 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asn Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Ala Ser Arg Glu Glu Val Asp Val Pro Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Ser Gln Pro Phe Cys Ile Cys 
            500                 505                 


<210>  20
<211>  509
<212>  PRT
<213>  Bos taurus

<400>  20

Met Ala Asp Arg Ala Ala Leu Glu Asp Leu Val Arg Val Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Gly Lys Pro Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Ser Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Leu Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Pro Pro Ala Arg Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Ile Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Thr Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Ala Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Ser Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  21
<211>  508
<212>  PRT
<213>  Rattus norvegicus

<400>  21

Met Ala Asp Arg Ala Ala Leu Glu Glu Leu Val Arg Leu Gln Gly Ala 
1               5                   10                  15      


His Val Arg Gly Leu Lys Glu Gln Lys Ala Ser Ala Glu Gln Ile Glu 
            20                  25                  30          


Glu Glu Val Thr Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly His Asp 
        35                  40                  45              


Glu Gly Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asn Phe Gln 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys 
    210                 215                 220                 


Gly Val Pro Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Val Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Met Pro Thr Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Ile Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Lys Leu Glu Ala Ser 
385                 390                 395                 400 


Glu Glu Lys Val Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Ile Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Arg Arg Arg Thr Ser Gln Pro Leu Ser Met 
            500                 505             


<210>  22
<211>  500
<212>  PRT
<213>  Gallus gallus

<400>  22

Met Ala Asp Glu Ala Ala Val Arg Gln Gln Ala Glu Val Val Arg Arg 
1               5                   10                  15      


Leu Lys Gln Asp Lys Ala Glu Pro Asp Glu Ile Ala Lys Glu Val Ala 
            20                  25                  30          


Lys Leu Leu Glu Met Lys Ala His Leu Gly Gly Asp Glu Gly Lys His 
        35                  40                  45              


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Gly Pro Lys 
    50                  55                  60                  


Gln Met Ala Ile Arg Glu Arg Val Phe Ser Ala Ile Ile Ala Cys Phe 
65                  70                  75                  80  


Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val Phe Glu Leu Lys 
                85                  90                  95      


Glu Thr Leu Thr Gly Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp 
            100                 105                 110         


Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr 
        115                 120                 125             


Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Ile Thr Asn Ile Lys 
    130                 135                 140                 


Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr 
145                 150                 155                 160 


Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly 
                165                 170                 175     


Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys Ile Val Gln 
            180                 185                 190         


Glu Ile Leu Ser Asp Leu Gln Leu Gly Asp Phe Leu Ile Lys Val Asn 
        195                 200                 205             


Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Val Cys Gly Val Pro Asp 
    210                 215                 220                 


Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys Met 
225                 230                 235                 240 


Pro Trp Glu Glu Val Arg Asn Glu Met Val Gly Glu Lys Gly Leu Ser 
                245                 250                 255     


Pro Glu Ala Ala Asp Arg Ile Gly Glu Tyr Val Gln Leu His Gly Gly 
            260                 265                 270         


Met Asp Leu Ile Glu Gln Leu Leu Gln Asp Pro Lys Leu Ser Gln Asn 
        275                 280                 285             


Lys Leu Val Lys Glu Gly Leu Gly Asp Met Lys Leu Leu Phe Glu Tyr 
    290                 295                 300                 


Leu Thr Leu Phe Gly Ile Thr Gly Lys Ile Ser Phe Asp Leu Ser Leu 
305                 310                 315                 320 


Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Val Leu 
                325                 330                 335     


Leu Gln Gln Asn Asp His Gly Glu Glu Ser Val Ser Val Gly Ser Val 
            340                 345                 350         


Ala Gly Gly Gly Arg Tyr Asp Gly Leu Val Gly Met Phe Asp Pro Lys 
        355                 360                 365             


Gly Arg Lys Val Pro Cys Val Gly Ile Ser Ile Gly Ile Glu Arg Ile 
    370                 375                 380                 


Phe Ser Ile Leu Glu Gln Arg Val Glu Ala Ser Glu Glu Lys Ile Arg 
385                 390                 395                 400 


Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln Lys Lys Leu Leu 
                405                 410                 415     


Glu Glu Arg Leu Lys Leu Ile Ser Glu Leu Trp Asp Ala Gly Ile Lys 
            420                 425                 430         


Ala Glu Val Leu Tyr Lys Lys Asn Pro Lys Leu Leu Asn Gln Leu Gln 
        435                 440                 445             


Tyr Cys Glu Asp Thr Gly Ile Pro Leu Val Ala Ile Val Gly Glu Gln 
    450                 455                 460                 


Glu Leu Lys Asp Gly Val Val Lys Leu Arg Val Val Ala Thr Gly Glu 
465                 470                 475                 480 


Glu Val Asn Ile Arg Arg Glu Ser Leu Val Glu Glu Ile Arg Arg Arg 
                485                 490                 495     


Thr Asn Gln Leu 
            500 


<210>  23
<211>  437
<212>  PRT
<213>  Danio rerio

<400>  23

Met Ala Ala Leu Gly Leu Val Ser Met Arg Leu Cys Ala Gly Leu Met 
1               5                   10                  15      


Gly Arg Arg Ser Ala Val Arg Leu His Ser Leu Arg Val Cys Ser Gly 
            20                  25                  30          


Met Thr Ile Ser Gln Ile Asp Glu Glu Val Ala Arg Leu Leu Gln Leu 
        35                  40                  45              


Lys Ala Gln Leu Gly Gly Asp Glu Gly Lys His Val Phe Val Leu Lys 
    50                  55                  60                  


Thr Ala Lys Gly Thr Arg Asp Tyr Asn Pro Lys Gln Met Ala Ile Arg 
65                  70                  75                  80  


Glu Lys Val Phe Asn Ile Ile Ile Asn Cys Phe Lys Arg His Gly Ala 
                85                  90                  95      


Glu Thr Ile Asp Ser Pro Val Phe Glu Leu Lys Glu Thr Leu Thr Gly 
            100                 105                 110         


Lys Tyr Gly Glu Asp Ser Lys Leu Ile Tyr Asp Leu Lys Asp Gln Gly 
        115                 120                 125             


Gly Glu Leu Leu Ser Leu Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg 
    130                 135                 140                 


Tyr Leu Ala Met Asn Lys Ile Thr Asn Ile Lys Arg Tyr His Ile Ala 
145                 150                 155                 160 


Lys Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg 
                165                 170                 175     


Glu Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Gln Tyr Asp Ala Met 
            180                 185                 190         


Ile Pro Asp Ala Glu Cys Leu Lys Leu Val Tyr Glu Ile Leu Ser Glu 
        195                 200                 205             


Leu Asp Leu Gly Asp Phe Arg Ile Lys Val Asn Asp Arg Arg Ile Leu 
    210                 215                 220                 


Asp Gly Met Phe Ala Ile Cys Gly Val Pro Asp Glu Lys Phe Arg Thr 
225                 230                 235                 240 


Ile Cys Ser Thr Val Asp Lys Leu Asp Lys Leu Ala Trp Glu Glu Val 
                245                 250                 255     


Lys Lys Glu Met Val Asn Glu Lys Gly Leu Ser Glu Glu Val Ala Asp 
            260                 265                 270         


Arg Ile Arg Asp Tyr Val Ser Met Gln Gly Gly Lys Asp Leu Ala Glu 
        275                 280                 285             


Arg Leu Leu Gln Asp Pro Lys Leu Ser Gln Ser Lys Gln Ala Cys Ala 
    290                 295                 300                 


Gly Ile Thr Asp Met Lys Leu Leu Phe Ser Tyr Leu Glu Leu Phe Gln 
305                 310                 315                 320 


Ile Thr Asp Lys Val Val Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp 
                325                 330                 335     


Tyr Tyr Thr Gly Val Ile Tyr Glu Ala Ile Leu Thr Gln Ala Asn Pro 
            340                 345                 350         


Ala Pro Ala Ser Thr Pro Ala Glu Gln Asn Gly Ala Glu Asp Ala Gly 
        355                 360                 365             


Val Ser Val Gly Ser Val Ala Gly Gly Gly Arg Tyr Asp Gly Leu Val 
    370                 375                 380                 


Gly Met Phe Asp Pro Lys Ala Gly Lys Cys Pro Val Trp Gly Ser Ala 
385                 390                 395                 400 


Leu Ala Leu Arg Gly Ser Ser Pro Ser Trp Ser Arg Arg Gln Ser Cys 
                405                 410                 415     


Leu Gln Arg Arg Cys Ala Pro Leu Lys Leu Lys Cys Leu Trp Leu Gln 
            420                 425                 430         


His Arg Arg Thr Phe 
        435         


<210>  24
<211>  1527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for wild type HisRs

<400>  24
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag      180

ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc      240

atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag      300

gaaacactga tgggaaagta tggggaagac tccaagctta tctatgacct gaaggaccag      360

ggcggggagc tcctgtccct tcgctatgac ctcactgttc cttttgctcg gtatttggca      420

atgaataaac tgaccaacat taaacgctac cacatagcaa aggtatatcg gcgggataac      480

ccagccatga cccgtggccg ataccgggaa ttctaccagt gtgattttga cattgctggg      540

aactttgatc ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga gatcctgagt      600

tcacttcaga taggcgactt cctggtcaag gtaaacgatc gacgcattct agatgggatg      660

tttgctatct gtggtgtttc tgacagcaag ttccgtacca tctgctcctc agtagacaag      720

ctggacaagg tgtcctggga agaggtgaag aatgagatgg tgggagagaa gggccttgca      780

cctgaggtgg ctgaccgcat tggggactat gtccagcaac atggtggggt atccctggtg      840

gaacagctgc tccaggatcc taaactatcc caaaacaagc aggccttgga gggcctggga      900

gacctgaagt tgctctttga gtacctgacc ctatttggca ttgatgacaa aatctccttt      960

gacctgagcc ttgctcgagg gctggattac tacactgggg tgatctatga ggcagtgctg     1020

ctacagaccc cagcccaggc aggggaagag cccctgggtg tgggcagtgt ggctgctgga     1080

ggacgctatg atgggctagt gggcatgttc gaccccaaag ggcgcaaggt gccatgtgtg     1140

gggctcagca ttggggtgga gcggattttc tccatcgtgg aacagagact agaggctttg     1200

gaggagaaga tacggaccac ggagacacag gtgcttgtgg catctgcaca gaagaagctg     1260

ctagaggaaa gactaaagct tgtctcagaa ctgtgggatg ctgggatcaa ggctgagctg     1320

ctgtacaaga agaacccaaa gctactgaac cagttacagt actgtgagga ggcaggcatc     1380

ccactggtgg ctatcatcgg cgagcaggaa ctcaaggatg gggtcatcaa gctccgttca     1440

gtgacgagca gggaagaggt ggatgtccga agagaagacc ttgtggagga aatcaaaagg     1500

agaacaggcc agcccctctg catctgc                                         1527


<210>  25
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for N-terminal fragment of 
       HisRS1

<400>  25
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaacccgtg actattctcc tcgtcaaatg gccgtccgtg aaaaagtgtt cgacgtgatc      240

attcgctgct ttaaacgcca tggtgccgaa gtgattgata ccccggtgtt tgagctgaaa      300

gagacactga tgggcaaata tggtgaggac agcaaactga tttatgacct gaaagatcag      360

ggtggtgaac tgctgagtct gcgctatgat ctgacagttc cgtttgcccg ttatctggca      420

atg                                                                    423


<210>  26
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for N-terminal fragment of 
       HisRS1

<400>  26
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaacccgtg actattctcc tcgtcaaatg gccgtccgtg aaaaagtgtt cgacgtgatc      240

attcgctgct ttaaacgcca tggtgccgaa gtgattgata ccccggtgtt tgagctgaaa      300

gagacactga tgggcaaata tggtgaggac agcaaactga tttatgacct gaaagatcag      360

ggtggtgaac tgctgagtct gcgctatgat ctgacagttc cgtttgcccg ttatctggca      420

atgaataaac tgaccaacat taaacgctat cacattgcta aagtctatcg ccgtgacaat      480

cctgctatga cccgtggtcg ttatcgtgag ttctatcagt gtgacttcga tattgccggc      540

aactttgatc cgatgatccc ggatgctgaa tgcctgaaaa tcatgtgtga gatcctgagc      600

agtctgcaga ttggcgattt cctggtgaaa gtcaacgatc gccgtattct ggatggcatg      660

ttcgccatct gtggtgttag cgactccaaa ttccgtacca tctgtagtag tgtggacaaa      720

ctggataaag tgagctggga ggaggtgaaa aacgaaatgg tgggcgagaa aggtctggct      780

cctgaagtgg ctgaccgtat tggtgattat gtccagcagc acggtggagt atcactggtt      840

gagcaactgc tgcaagaccc taaactgagt cagaataaac aggccctgga gggactggga      900

gatctgaaac tgctgttcga gtatctgacc ctgttcggta tcgatgacaa aatctccttt      960

gacctgtcac tggctcgtgg actggactat tataccggcg tgatctatga agctgtactg     1020

ctgcaaactc cagcacaagc aggtgaagag cctctgggtg tgggtagtgt agccgctggg     1080

ggacgttatg atggactggt ggggatgttc gaccctaaag gccgtaaagt tccgtgtgtg     1140

ggtctgagta tcggtgttga gcgtatcttt tccatcgtcg agcaacgtct ggaagcactg     1200

gaggaaaaaa tccgtacgac cgaa                                            1224


<210>  27
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for N-terminal fragment of 
       HisRS1

<400>  27
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaacccgtg actattctcc tcgtcaaatg gccgtccgtg aaaaagtgtt cgacgtgatc      240

attcgctgct ttaaacgcca tggtgccgaa gtgattgata ccccggtgtt tgagctgaaa      300

gagacactga tgggcaaata tggtgaggac agcaaactg                             339


<210>  28
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for N-terminal fragment of 
       HisRS

<400>  28
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaag      180


<210>  29
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for intermediate fragment 
       of HisRS1

<400>  29
tgcctgaaaa tcatgtgtga gatcctgagt agtctgcaaa ttggcgactt tctggtcaaa       60

gtgaacgatc gccgtattct ggatggcatg ttcgccatct gtggtgttag cgactccaaa      120

ttccgtacaa tctgtagcag cgtggacaaa ctggataaag tgtcctggga agaggtgaaa      180

aacgaaatgg tgggtgaaaa aggtctggct ccggaggttg ctgaccgtat cggtgattat      240

gttcagcagc acggcggtgt tagtctggtt gaacaactgc tgcaagaccc gaaactgtct      300

cagaacaaac aggccctgga aggactggga gatctgaaac tgctgttcga gtatctgacg      360

ctgttcggca ttgatgacaa aatttctttc gacctgtcac tggcacgtgg actggactat      420

tataccggt                                                              429


<210>  30
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for C-terminal fragment of 
       HisRS1

<400>  30
cgtaccaccg aaacccaagt tctggttgcc tcagctcaga aaaaactgct ggaagaacgc       60

ctgaaactgg ttagcgaact gtgggatgct ggcattaaag ccgaactgct gtataaaaaa      120

aacccgaaac tgctgaatca gctgcagtat tgtgaggaag cgggtattcc tctggtggcc      180

attatcggag aacaggaact gaaagacggc gttattaaac tgcgtagcgt gacctctcgt      240

gaagaagttg acgttcgccg tgaagatctg gtcgaggaaa tcaaacgtcg taccggtcaa      300

cctctgtgta tttgc                                                       315


<210>  31
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for N-terminal fragment of 
       HisRS1

<400>  31
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaacccgtg actattctcc tcgtcaaatg gccgtccgtg aaaaagtgtt cgacgtgatc      240

attcgctgct ttaaacgcca tggtgccgaa gtgattgata ccccggtgtt tgagctgaaa      300

gagacactga tgggcaaata tggtgaggac agcaaactga tctatgacct gaaagaccaa      360

ggcggtgaac tgctgtccct gcgttatgat ctgactgtgc cgtttgcccg ttatctggcc      420

atgaataaac tgacgaacat taaacgctat cacattgcca aagtgtatcg ccgtgacaat      480

cctgctatga ctcgtggacg ttatcgtgaa ttctatcagt gtgacttcga tattgccggc      540

aacttcgacc ctatgattcc ggatgctgaa tgcctgaaaa tcatgtgtga gatcctgagc      600

agcctgcaaa ttggtgactt cctggtgaaa gtgaatgacc gtcgtatcct ggatggcatg      660

tttgccattt gtggtgtgag cgattccaaa ttccgtacca tctgtagtag tgtggacaaa      720

ctggataaag tgggctatcc gtggtggaac tcttgtagcc gtattctgaa ctatcctaaa      780

accagccgcc cgtggcgtgc ttgggaaact                                       810


<210>  32
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for C-terminal fragment of 
       HisRS1

<400>  32
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

gacttcgata ttgccgggaa ttttgaccct atgatccctg atgccgaatg tctgaaaatc      240

atgtgtgaga tcctgagcag tctgcagatt ggtgacttcc tggtgaaagt gaacgatcgc      300

cgtattctgg atggaatgtt tgccatttgt ggcgtgtctg acagcaaatt tcgtacgatc      360

tgtagcagcg tggataaact ggataaagtg agctgggagg aggtgaaaaa tgagatggtg      420

ggcgaaaaag gtctggcacc tgaagtggct gaccgtatcg gtgattatgt tcagcaacat      480

ggcggtgttt ctctggtcga acagctgctg caagacccaa aactgagcca gaacaaacag      540

gcactggaag gactgggtga tctgaaactg ctgtttgagt atctgacgct gtttggcatc      600

gatgacaaaa tctcgtttga cctgagcctg gcacgtggtc tggattatta taccggcgtg      660

atctatgaag ccgtcctgct gcaaactcca gcacaagcag gtgaagaacc tctgggtgtt      720

ggtagtgtag cggcaggcgg acgttatgat ggactggtgg ggatgtttga tccgaaaggc      780

cgtaaagttc cgtgtgtcgg tctgagtatc ggggttgagc gtatctttag cattgtggag      840

caacgtctgg aagctctgga ggaaaaaatc cgtaccaccg aaacccaagt tctggttgcc      900

tcagctcaga aaaaactgct ggaagaacgc ctgaaactgg ttagcgaact gtgggatgct      960

ggcattaaag ccgaactgct gtataaaaaa aacccgaaac tgctgaatca gctgcagtat     1020

tgtgaggaag cgggtattcc tctggtggcc attatcggag aacaggaact gaaagacggc     1080

gttattaaac tgcgtagcgt gacctctcgt gaagaagttg acgttcgccg tgaagatctg     1140

gtcgaggaaa tcaaacgtcg taccggtcaa cctctgtgta tttgc                     1185


<210>  33
<211>  1077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for C-terminal fragment of 
       HisRS1

<400>  33
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

gtgaatgatc gccgtatcct ggatggcatg tttgccattt gtggtgtgag cgactcgaaa      240

ttccgtacga tttgctctag cgtcgataaa ctggacaaag tgtcctggga agaggtgaaa      300

aacgagatgg tgggtgagaa aggtctggct cctgaagttg ccgaccgtat tggtgattat      360

gttcagcagc atggcggtgt ttcactggtt gaacaactgc tgcaagaccc gaaactgtct      420

cagaataaac aggcgctgga aggactggga gatctgaaac tgctgtttga gtatctgacc      480

ctgttcggca ttgatgacaa aatcagcttc gacctgagcc tggcacgtgg tctggattat      540

tataccggcg tgatctatga agccgttctg ctgcagacac cagcacaagc aggcgaagaa      600

cctctgggtg ttggttctgt ggcagccggt ggtcgttatg atggactggt aggcatgttc      660

gatccgaaag gccgtaaagt tccgtgtgtg ggactgagta tcggtgttga gcgtatcttt      720

agcatcgtgg aacaacgtct ggaagcgctg gaggagaaaa ttcgtaccac cgaaacccaa      780

gttctggttg cctcagctca gaaaaaactg ctggaagaac gcctgaaact ggttagcgaa      840

ctgtgggatg ctggcattaa agccgaactg ctgtataaaa aaaacccgaa actgctgaat      900

cagctgcagt attgtgagga agcgggtatt cctctggtgg ccattatcgg agaacaggaa      960

ctgaaagacg gcgttattaa actgcgtagc gtgacctctc gtgaagaagt tgacgttcgc     1020

cgtgaagatc tggtcgagga aatcaaacgt cgtaccggtc aacctctgtg tatttgc        1077


<210>  34
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized nucleic acid sequence for C-terminal fragment of 
       HisRS1

<400>  34
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaactcgtg attatagccc tcgccagatg gctgtccgtg aaaaagtgtt cgatgtgatc      240

attcgctgct tcaaacgtca tggtgccgaa gtcattgata ccccggtgtt cgagctgaaa      300

gtgaacgatc gccgtattct ggatggcatg ttcgccattt gtggtgttag cgatagcaaa      360

ttccgtacaa tctgctctag cgtggacaaa ctggacaaag tgagctggga agaggtgaaa      420

aacgagatgg tgggtgagaa aggcctggct cctgaagttg ccgaccgtat cggagattat      480

gttcagcagc atggcggagt ttcactggtt gaacaactgc tgcaagaccc gaaactgtct      540

cagaacaaac aggcactgga aggtctggga gatctgaaac tgctgttcga gtatctgacg      600

ctgttcggta ttgacgacaa aatttccttc gacctgtcgc tggcacgtgg tctggattat      660

tatacaggcg tgatctatga ggctgtactg ctgcagacac cagcacaagc aggtgaagag      720

cctctgggtg ttggttcagt tgctgccggt ggacgttatg acggactggt agggatgttt      780

gacccaaaag gccgtaaagt cccgtgtgta ggactgtcta ttggcgttga gcgtatcttt      840

agcatcgtgg agcaacgtct ggaagctctg gaggagaaaa tccgtaccac cgaaacccaa      900

gttctggttg cctcagctca gaaaaaactg ctggaagaac gcctgaaact ggttagcgaa      960

ctgtgggatg ctggcattaa agccgaactg ctgtataaaa aaaacccgaa actgctgaat     1020

cagctgcagt attgtgagga agcgggtatt cctctggtgg ccattatcgg agaacaggaa     1080

ctgaaagacg gcgttattaa actgcgtagc gtgacctctc gtgaagaagt tgacgttcgc     1140

cgtgaagatc tggtcgagga aatcaaacgt cgtaccggtc aacctctgtg tatttgc        1197


<210>  35
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for C-terminal fragment of 
       HisRS1

<400>  35
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaactcgtg attatagccc tcgccagatg gctgtccgtg aaaaagtgtt cgatgtgatc      240

attcgctgct tcaaacgtca tggtgccgaa gtcattgata ccccggtgtt cgagctgaaa      300

gaaaccctga tgggcaaata tggggaagat tccaaactga tctatgacct gaaagaccag      360

ggaggtgaac tgctgtctct gcgctatgac ctgactgttc cttttgctcg ctatctggcc      420

atgaataaac tgaccaacat caaacgctat catatcgcca aagtgtatcg ccgtgacaat      480

ccagcaatga cccgtggtcg ttatcgtgaa ttttatcagt gtgtgaacga tcgccgtatt      540

ctggacggca tgttcgccat ttgtggtgtg tctgactcca aatttcgtac gatctgctca      600

agcgtggaca aactggacaa agtgagctgg gaagaggtga aaaacgagat ggtgggtgag      660

aaaggcctgg ctcctgaagt tgccgaccgt atcggagatt atgttcagca gcatggcgga      720

gtttcactgg ttgaacaact gctgcaagac ccgaaactgt cacagaacaa acaggcactg      780

gaaggtctgg gggatctgaa actgctgttc gagtatctga cgctgttcgg tattgacgac      840

aaaatcagct tcgatctgag cctggcacgt ggtctggact attataccgg cgtgatttat      900

gaagccgttc tgctgcagac tccagcacaa gcaggtgaag agcctctggg tgttggaagt      960

gtggcagccg gtggccgtta tgatggtctg gttggcatgt ttgacccgaa aggccgtaaa     1020

gtcccgtgtg taggactgtc tatcggcgtg gagcgtattt ttagcatcgt ggaacaacgc     1080

ctggaagctc tggaagagaa aatccgtacc accgaaaccc aagttctggt tgcctcagct     1140

cagaaaaaac tgctggaaga acgcctgaaa ctggttagcg aactgtggga tgctggcatt     1200

aaagccgaac tgctgtataa aaaaaacccg aaactgctga atcagctgca gtattgtgag     1260

gaagcgggta ttcctctggt ggccattatc ggagaacagg aactgaaaga cggcgttatt     1320

aaactgcgta gcgtgacctc tcgtgaagaa gttgacgttc gccgtgaaga tctggtcgag     1380

gaaatcaaac gtcgtaccgg tcaacctctg tgtatttgc                            1419


<210>  36
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for C-terminal fragment of 
       HisRS1

<400>  36
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

gaaaccctga tgggcaaata tggcgaagat tccaaactga tctatgacct gaaagaccaa      240

ggcggtgaac tgctgtccct gcgttatgac ctgactgttc cgtttgctcg ttatctggcc      300

atgaataaac tgaccaacat taaacgctat cacattgcca aagtgtatcg ccgtgacaat      360

cctgctatga ctcgtggacg ttatcgtgaa ttctatcagt gtgacttcga tattgccggc      420

aacttcgacc ctatgattcc ggatgctgaa tgcctgaaaa tcatgtgtga gatcctgagc      480

agcctgcaaa ttggtgactt cctggtgaaa gtgaatgacc gtcgtatcct ggatggcatg      540

ttcgccattt gtggtgttag cgattccaaa ttccgtacca tctgtagtag tgtggacaaa      600

ctggataaag tgagctggga agaggtgaaa aacgaaatgg tgggcgaaaa aggtctggca      660

cctgaggttg ctgatcgtat cggtgactat gtccagcagc atggaggtgt ttcactggtt      720

gagcaactgc tgcaagatcc gaaactgtct cagaacaaac aggccctgga aggactgggt      780

gatctgaaac tgctgttcga gtatctgacg ctgttcggta ttgatgacaa aatctcgttc      840

gacctgtctc tggctcgtgg actggattat tatacgggcg taatctatga agctgtcctg      900

ctgcagacac cagcacaagc aggtgaagag cctctgggtg ttggaagtgt tgctgccggt      960

ggtcgctatg acggactggt tggcatgttc gatccgaaag gccgtaaagt tccgtgtgta     1020

ggactgagca ttggcgttga gcgtatcttt tccatcgttg agcaacgtct ggaagcactg     1080

gaagagaaaa tccgtaccac cgaaacccaa gttctggttg cctcagctca gaaaaaactg     1140

ctggaagaac gcctgaaact ggttagcgaa ctgtgggatg ctggcattaa agccgaactg     1200

ctgtataaaa aaaacccgaa actgctgaat cagctgcagt attgtgagga agcgggtatt     1260

cctctggtgg ccattatcgg agaacaggaa ctgaaagacg gcgttattaa actgcgtagc     1320

gtgacctctc gtgaagaagt tgacgttcgc cgtgaagatc tggtcgagga aatcaaacgt     1380

cgtaccggtc aacctctgtg tatttgc                                         1407


<210>  37
<211>  1305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence from C-terminal of HisRS1

<400>  37
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgatgaatca aaacaaaaat tcgtcctgaa aactccgaaa      180

ggaactcgtg attatagccc tcgccagatg gctgtccgtg aaaaagtgtt cgatgtgatc      240

attcgctgct tcaaacgtca tggtgccgaa gtcattgata ccccggtgtt cgagctgaaa      300

gatttcgata ttgccggcaa ctttgatccg atgattccgg atgctgagtg tctgaaaatc      360

atgtgtgaga tcctgagtag tctgcagatt ggggatttcc tggtgaaagt gaacgatcgc      420

cgtattctgg acggcatgtt tgccatttgt ggcgttagcg atagcaaatt ccgtacgatc      480

tgtagcagtg tggacaaact ggataaagtc tcttgggaag aggtcaaaaa cgagatggtt      540

ggtgagaaag gcctggctcc tgaagtggct gaccgtattg gtgattatgt ccagcagcat      600

ggtggtgttt cactggttga acaactgctg caagacccga aactgtctca gaacaaacag      660

gcactggaag gtctgggtga tctgaaactg ctgttcgagt atctgacgct gttcggtatt      720

gacgacaaaa tttccttcga cctgtcactg gcacgtggtc tggattatta tacaggcgta      780

atctatgagg ctgtactgct gcaaactcca gcacaagcag gtgaagaacc tctgggagtt      840

ggtagtgtag cggcaggggg tcgttatgat gggctggtcg ggatgttcga tccaaaaggc      900

cgtaaagtcc cgtgtgttgg tctgtctatt ggcgttgagc gtatcttctc catcgtggag      960

caacgtctgg aagctctgga agaaaaaatc cgtaccaccg aaacccaagt tctggttgcc     1020

tcagctcaga aaaaactgct ggaagaacgc ctgaaactgg ttagcgaact gtgggatgct     1080

ggcattaaag ccgaactgct gtataaaaaa aacccgaaac tgctgaatca gctgcagtat     1140

tgtgaggaag cgggtattcc tctggtggcc attatcggag aacaggaact gaaagacggc     1200

gttattaaac tgcgtagcgt gacctctcgt gaagaagttg acgttcgccg tgaagatctg     1260

gtcgaggaaa tcaaacgtcg taccggtcaa cctctgtgta tttgc                     1305


<210>  38

<400>  38
000

<210>  39
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Pro Leu Leu Gly Leu Leu Pro Arg Arg Ala Trp Ala Ser Leu Leu 
1               5                   10                  15      


Ser Gln Leu Leu Arg Pro Pro Cys Ala Ser Cys Thr Gly Ala Val Arg 
            20                  25                  30          


Cys Gln Ser Gln Val Ala Glu Ala Val Leu Thr Ser Gln Leu Lys Ala 
        35                  40                  45              


His Gln Glu Lys Pro Asn Phe Ile Ile Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60                  


Asp Leu Ser Pro Gln His Met Val Val Arg Glu Lys Ile Leu Asp Leu 
65                  70                  75                  80  


Val Ile Ser Cys Phe Lys Arg His Gly Ala Lys Gly Met Asp Thr Pro 
                85                  90                  95      


Ala Phe Glu Leu Lys Glu Thr Leu Thr Glu Lys Tyr Gly Glu Asp Ser 
            100                 105                 110         


Gly Leu Met Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu 
        115                 120                 125             


Arg Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys 
    130                 135                 140                 


Val Lys Lys Met Lys Arg Tyr His Val Gly Lys Val Trp Arg Arg Glu 
145                 150                 155                 160 


Ser Pro Thr Ile Val Gln Gly Arg Tyr Arg Glu Phe Cys Gln Cys Asp 
                165                 170                 175     


Phe Asp Ile Ala Gly Gln Phe Asp Pro Met Ile Pro Asp Ala Glu Cys 
            180                 185                 190         


Leu Lys Ile Met Cys Glu Ile Leu Ser Gly Leu Gln Leu Gly Asp Phe 
        195                 200                 205             


Leu Ile Lys Val Asn Asp Arg Arg Ile Val Asp Gly Met Phe Ala Val 
    210                 215                 220                 


Cys Gly Val Pro Glu Ser Lys Phe Arg Ala Ile Cys Ser Ser Ile Asp 
225                 230                 235                 240 


Lys Leu Asp Lys Met Ala Trp Lys Asp Val Arg His Glu Met Val Val 
                245                 250                 255     


Lys Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val 
            260                 265                 270         


Gln Cys His Gly Gly Val Ser Leu Val Glu Gln Met Phe Gln Asp Pro 
        275                 280                 285             


Arg Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys 
    290                 295                 300                 


Leu Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Ala Asp Lys Ile Ser 
305                 310                 315                 320 


Phe Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile 
                325                 330                 335     


Tyr Glu Ala Val Leu Leu Gln Thr Pro Thr Gln Ala Gly Glu Glu Pro 
            340                 345                 350         


Leu Asn Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val 
        355                 360                 365             


Gly Met Phe Asp Pro Lys Gly His Lys Val Pro Cys Val Gly Leu Ser 
    370                 375                 380                 


Ile Gly Val Glu Arg Ile Phe Tyr Ile Val Glu Gln Arg Met Lys Thr 
385                 390                 395                 400 


Lys Gly Glu Lys Val Arg Thr Thr Glu Thr Gln Val Phe Val Ala Thr 
                405                 410                 415     


Pro Gln Lys Asn Phe Leu Gln Glu Arg Leu Lys Leu Ile Ala Glu Leu 
            420                 425                 430         


Trp Asp Ser Gly Ile Lys Ala Glu Met Leu Tyr Lys Asn Asn Pro Lys 
        435                 440                 445             


Leu Leu Thr Gln Leu His Tyr Cys Glu Ser Thr Gly Ile Pro Leu Val 
    450                 455                 460                 


Val Ile Ile Gly Glu Gln Glu Leu Lys Glu Gly Val Ile Lys Ile Arg 
465                 470                 475                 480 


Ser Val Ala Ser Arg Glu Glu Val Ala Ile Lys Arg Glu Asn Phe Val 
                485                 490                 495     


Ala Glu Ile Gln Lys Arg Leu Ser Glu Ser 
            500                 505     


<210>  40
<211>  198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized DNA endcoding resokine (N-terminal fragment of 
       HisRS) for E. coli expression

<400>  40
atggcagaac gtgcggcatt ggaagaattg gttaaactgc aaggtgaacg tgttcgtggt       60

ctgaagcagc agaaggctag cgcggagctg atcgaagaag aggtggccaa actgctgaag      120

ctgaaggcgc agctgggccc ggacgagagc aaacaaaagt tcgtcctgaa aaccccgaaa      180

caccaccatc accatcac                                                    198


<210>  41
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Resokine (N-terminal fragment of HisRs) with His tag

<400>  41

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys His His His His 
    50                  55                  60                  


His His 
65      


<210>  42
<211>  1563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized full length HisRS gene for E. coli expression

<400>  42
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgttatg tatttgcgcg gccgcactcg agcaccacca ccaccaccac     1560

tga                                                                   1563


<210>  43
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length HisRS with His tag

<400>  43

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys Ala Ala Ala 
            500                 505                 510         


Leu Glu His His His His His His 
        515                 520 


<210>  44
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer designed to selectively mutate cysteine residue

<400>  44
gtttgacgta atcatccgtt gcttcaagcg ccacggtgca g                           41


<210>  45
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer designed to selectively mutate cysteine residue

<400>  45
ctgcaccgtg gcgcttgaag caacggatga ttacgtcaaa c                           41


<210>  46
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer designed to selectively mutate cysteine residue

<400>  46
gccgataccg ggaattctac cagtgtgatt ttgacattgc tggg                        44


<210>  47
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer designed to selectively mutate cysteine residue

<400>  47
cccagcaatg tcaaaatcac actggtagaa ttcccggtat cggc                        44


<210>  48
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  48
ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga g                           41


<210>  49
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  49
ctcgcacatg atcttcaggc actctgcatc agggatcatg g                           41


<210>  50
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  50
gcagagtgcc tgaagatcat gtgcgagatc ctgagttcac ttc                         43


<210>  51
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primere

<400>  51
gaagtgaact caggatctcg cacatgatct tcaggcactc tgc                         43


<210>  52
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52
ctagatggga tgtttgctat ctgtggtgtt tctgacagca agttc                       45


<210>  53
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53
gaacttgctg tcagaaacac cacagatagc aaacatccca tctag                       45


<210>  54
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primier

<400>  54
cagcaagttc cgtaccatct gctcctcagt agacaagctg g                           41


<210>  55
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primieer

<400>  55
ccagcttgtc tactgaggag cagatggtac ggaacttgct g                           41


<210>  56
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primier

<400>  56
gggcgcaagg tgccatgtgt ggggctcagc attgggg                                37


<210>  57
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primier

<400>  57
ccccaatgct gagccccaca catggcacct tgcgccc                                37


<210>  58
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  58
ctgaaccagt tacagtactg tgaggaggca ggcatccc                               38


<210>  59
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primier

<400>  59
gggatgcctg cctcctcaca gtactgtaac tggttcag                               38


<210>  60
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primier

<400>  60
gagaacaggc cagcccctct gcatctgcta gaacccagc                              39


<210>  61
<211>  39
<212>  DNA
<213>  Artificial Sequenc

<220>
<223>  primeir

<400>  61
gctgggttct agcagatgca gaggggctgg cctgttctc                              39


<210>  62
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primeir

<400>  62
ccagcccctc tgcatctgct agaacccagc tttcttg                                37


<210>  63
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  63
caagaaagct gggttctagc agatgcagag gggctgg                                37


<210>  64
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  64
gaacaggcca gcccctctag aacccagctt tcttg                                  35


<210>  65
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primier

<400>  65
caagaaagct gggttctaga ggggctggcc tgttc                                  35


<210>  66
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  66
cgccgcaccg gtcaaccgtt acaccaccac caccaccact g                           41


<210>  67
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  67
cagtggtggt ggtggtggtg taacggttga ccggtgcggc g                           41


<210>  68
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  68
cgccgcaccg gtcaaccgtt atgagatccg gctgctaac                              39


<210>  69
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  69
gttagcagcc ggatctcata acggttgacc ggtgcggcg                              39


<210>  70
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  71
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


<210>  72
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid sequence for N-terminal fragment of 
       HisRS1

<400>  72
atggcagagc gtgcggcgct ggaggagctg gtgaaacttc agggagagcg cgtgcgaggc       60

ctcaagcagc agaaggccag cgccgagctg atcgaggagg aggtggcgaa actcctgaaa      120

ctgaaggcac agctgggtcc tgatgaaagc aaacagaaat ttgtgctcaa aacccccaag      180

ggcacaagag actatagtcc ccggcagatg gcagttcgcg agaaggtgtt tgacgtaatc      240

atccgttgct tcaagcgcca cggtgcagaa gtcattgata cacctgtatt tgaactaaag      300

gaaacactga tgggaaagta tggggaagac tccaagctta tctatgacct gaaggaccag      360

ggcggggagc tcctgtccct tcgctatgac ctcactgttc cttttgctcg gtatttggca      420

atgaataaac tgaccaacat taaacgctac cacatagcaa aggtatatcg gcgggataac      480

ccagccatga cccgtggccg ataccgggaa ttctaccagt gtgattttga cattgctggg      540

aactttgatc ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga gatcctgagt      600

tcacttcaga taggcgactt cctggtcaag gtaaacgatc gacgcattct agatgggatg      660

tttgctatct gtggtgtttc tgacagcaag ttccgtacca tctgctcctc agtagacaag      720

ctggacaagg tgtcctggga agaggtgaag aatgagatgg tgggagagaa gggccttgca      780

cctgaggtgg ctgaccgcat tggggactat gtccagcaac atggtggggt atccctggtg      840

gaacagctgc tccaggatcc taaactatcc caaaacaagc aggccttgga gggcctggga      900

gacctgaagt tgctctttga gtacctgacc ctatttggca ttgatgacaa aatctccttt      960

gacctgagcc ttgctcgagg gctggattac tacactgggg tgatctatga ggcagtgctg     1020

ctacagaccc cagcccaggc aggggaagag cccctgggtg tgggcagtgt ggctgctgga     1080

ggacgctatg atgggctagt gggcatgttc gaccccaaag ggcgcaaggt gccatgtgtg     1140

gggctcagca ttggggtgga gcggattttc tccatcgtgg aacagagact agaggctttg     1200

gaggagaaga tacggaccac ggagacacag gtgcttgtgg catctgcaca gaagaagctg     1260

ctagaggaaa gactaaagct tgtctcagaa ctgtgggatg ctgggatcaa ggctgagctg     1320

ctgtacaaga agaacccaaa gctactgaac cagttacagt actgtgagga ggcaggcatc     1380

ccactggtgg ctatcatcgg cgagcaggaa ctcaaggatg gggtcatcaa gctccgttca     1440

gtgacgagca gggaagaggt ggatgtccga agagaagacc ttgtggagga aatcaaaagg     1500

agaacaggcc agcccctc                                                   1518


<210>  73
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized nucleic acid fragment for N-terminal fragment of 
       HisRS1

<400>  73
atggcagaac gtgccgccct ggaagagctg gtaaaactgc aaggcgagcg tgttcgtggt       60

ctgaaacagc agaaagcaag cgctgaactg atcgaagaag aagtggcgaa actgctgaaa      120

ctgaaagcac agctgggtcc tgat                                             144


<210>  74
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


<210>  75
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val 
65                  70                  75                  


<210>  76
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp 
65                  70                  75              


<210>  77
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
65                  70                  75          


<210>  78
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
65                  70                  75      


<210>  79
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys 
65                  70                  75  


<210>  80
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu 
65                  70                  


<210>  81
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg 
65                  70              


<210>  82
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val 
65                  70          


<210>  83
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala 
65                  70      


<210>  84
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met 
65                  70  


<210>  85
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln 
65                  


<210>  86
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg 
65              


<210>  87
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro 
65          


<210>  88
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser 
65      


<210>  89
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr 
65  


<210>  90
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


<210>  91
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg 
    50                  55                  60              


<210>  92
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr 
    50                  55                  60          


<210>  93
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
    50                  55                  60      


<210>  94
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  95
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro 
    50                  55                  


<210>  96
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr 
    50                  55              


<210>  97
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys 
    50                  55          


<210>  98
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu 
    50                  55      


<210>  99
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val 
    50                  55  


<210>  100
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe 
    50                  


<210>  101
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys 
    50              


<210>  102
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln 
    50          


<210>  103
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys 
    50      


<210>  104
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser 
    50  


<210>  105
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu 
    


<210>  106
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


<210>  107
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
        35                  40                  45          


<210>  108
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly 
        35                  40                  45      


<210>  109
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
        35                  40                  45  


<210>  110
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
        35                  40                  


<210>  111
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala 
        35                  40              


<210>  112
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys 
        35                  40          


<210>  113
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu 
        35                  40      


<210>  114
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys 
        35                  40  


<210>  115
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  115

Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg 
1               5                   10                  15      


Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
            20                  25                  30          


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
        35                  40                  45              


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
    50                  55                  60                  


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  


<210>  116
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  116

Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val 
1               5                   10                  15      


Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu 
            20                  25                  30          


Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
        35                  40                  45              


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser 
    50                  55                  60                  


Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75              


<210>  117
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  117

Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg 
1               5                   10                  15      


Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val 
            20                  25                  30          


Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys 
        35                  40                  45              


Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro 
    50                  55                  60                  


Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75          


<210>  118
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  118

Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly 
1               5                   10                  15      


Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala 
            20                  25                  30          


Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln 
        35                  40                  45              


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg 
    50                  55                  60                  


Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75      


<210>  119
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  119

Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu 
1               5                   10                  15      


Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys 
            20                  25                  30          


Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys 
        35                  40                  45              


Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
    50                  55                  60                  


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75  


<210>  120
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  120

Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys 
1               5                   10                  15      


Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu 
            20                  25                  30          


Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe 
        35                  40                  45              


Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met 
    50                  55                  60                  


Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  


<210>  121
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  121

Glu Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln 
1               5                   10                  15      


Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu 
            20                  25                  30          


Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
        35                  40                  45              


Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala 
    50                  55                  60                  


Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70              


<210>  122
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  122

Glu Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln 
1               5                   10                  15      


Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys 
            20                  25                  30          


Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu 
        35                  40                  45              


Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val 
    50                  55                  60                  


Arg Glu Lys Val Phe Asp Val Ile 
65                  70          


<210>  123
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  123

Leu Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys 
1               5                   10                  15      


Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu 
            20                  25                  30          


Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys 
        35                  40                  45              


Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg 
    50                  55                  60                  


Glu Lys Val Phe Asp Val Ile 
65                  70      


<210>  124
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  124

Val Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala 
1               5                   10                  15      


Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys 
            20                  25                  30          


Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr 
        35                  40                  45              


Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu 
    50                  55                  60                  


Lys Val Phe Asp Val Ile 
65                  70  


<210>  125
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  125

Lys Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser 
1               5                   10                  15      


Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala 
            20                  25                  30          


Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro 
        35                  40                  45              


Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys 
    50                  55                  60                  


Val Phe Asp Val Ile 
65                  


<210>  126
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  126

Leu Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala 
1               5                   10                  15      


Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
            20                  25                  30          


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
        35                  40                  45              


Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
    50                  55                  60                  


Phe Asp Val Ile 
65              


<210>  127
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  127

Gln Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu 
1               5                   10                  15      


Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
            20                  25                  30          


Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
        35                  40                  45              


Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
    50                  55                  60                  


Asp Val Ile 
65          


<210>  128
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  128

Gly Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu 
1               5                   10                  15      


Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly 
            20                  25                  30          


Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr 
        35                  40                  45              


Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp 
    50                  55                  60                  


Val Ile 
65      


<210>  129
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  129

Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
1               5                   10                  15      


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
            20                  25                  30          


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
        35                  40                  45              


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60                  


<210>  130
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  130

Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
1               5                   10                  15      


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
            20                  25                  30          


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
        35                  40                  45              


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60              


<210>  131
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  131

Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu 
1               5                   10                  15      


Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
            20                  25                  30          


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser 
        35                  40                  45              


Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60          


<210>  132
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  132

Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val 
1               5                   10                  15      


Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys 
            20                  25                  30          


Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro 
        35                  40                  45              


Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60      


<210>  133
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  133

Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala 
1               5                   10                  15      


Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln 
            20                  25                  30          


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg 
        35                  40                  45              


Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  60  


<210>  134
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  134

Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys 
1               5                   10                  15      


Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys 
            20                  25                  30          


Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
        35                  40                  45              


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55                  


<210>  135
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  135

Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu 
1               5                   10                  15      


Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe 
            20                  25                  30          


Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met 
        35                  40                  45              


Ala Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55              


<210>  136
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  136

Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu 
1               5                   10                  15      


Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
            20                  25                  30          


Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala 
        35                  40                  45              


Val Arg Glu Lys Val Phe Asp Val Ile 
    50                  55          


<210>  137
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  137

Lys Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys 
1               5                   10                  15      


Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu 
            20                  25                  30          


Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val 
        35                  40                  45              


Arg Glu Lys Val Phe Asp Val Ile 
    50                  55      


<210>  138
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  138

Ala Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu 
1               5                   10                  15      


Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys 
            20                  25                  30          


Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg 
        35                  40                  45              


Glu Lys Val Phe Asp Val Ile 
    50                  55  


<210>  139
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  139

Ser Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys 
1               5                   10                  15      


Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr 
            20                  25                  30          


Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu 
        35                  40                  45              


Lys Val Phe Asp Val Ile 
    50                  


<210>  140
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  140

Ala Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala 
1               5                   10                  15      


Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys 
        35                  40                  45              


Val Phe Asp Val Ile 
    50              


<210>  141
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  141

Glu Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln 
1               5                   10                  15      


Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
            20                  25                  30          


Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val 
        35                  40                  45              


Phe Asp Val Ile 
    50          


<210>  142
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  142

Leu Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu 
1               5                   10                  15      


Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly 
            20                  25                  30          


Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe 
        35                  40                  45              


Asp Val Ile 
    50      


<210>  143
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  143

Ile Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly 
1               5                   10                  15      


Pro Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr 
            20                  25                  30          


Arg Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp 
        35                  40                  45              


Val Ile 
    50  


<210>  144
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  144

Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
1               5                   10                  15      


Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg 
            20                  25                  30          


Asp Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val 
        35                  40                  45              


Ile 
    


<210>  145
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  145

Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
1               5                   10                  15      


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
            20                  25                  30          


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45              


<210>  146
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  146

Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
1               5                   10                  15      


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
            20                  25                  30          


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45          


<210>  147
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  147

Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser 
1               5                   10                  15      


Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser 
            20                  25                  30          


Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45      


<210>  148
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  148

Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys 
1               5                   10                  15      


Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro 
            20                  25                  30          


Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  45  


<210>  149
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  149

Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln 
1               5                   10                  15      


Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg 
            20                  25                  30          


Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40                  


<210>  150
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  150

Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys 
1               5                   10                  15      


Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln 
            20                  25                  30          


Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40              


<210>  151
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  151

Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe 
1               5                   10                  15      


Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met 
            20                  25                  30          


Ala Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40          


<210>  152
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  152

Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val 
1               5                   10                  15      


Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala 
            20                  25                  30          


Val Arg Glu Lys Val Phe Asp Val Ile 
        35                  40      


<210>  153
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  153

Leu Lys Ala Gln Leu Gly Pro Asp Glu Ser Lys Gln Lys Phe Val Leu 
1               5                   10                  15      


Lys Thr Pro Lys Gly Thr Arg Asp Tyr Ser Pro Arg Gln Met Ala Val 
            20                  25                  30          


Arg Glu Lys Val Phe Asp Val Ile 
        35                  40  

<210>  154
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  154
aaacaaaaca aaaca                                                        15


<210>  155
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  155
aaacaaaaca                                                              10


<210>  156
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  156
caaaacaaaa                                                              10


<210>  157
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  157
caaaacaaaa caaaa                                                        15

<210>  158
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  158
aaacaaaaca                                                              10


<210>  159
<211>  10
<212>  DNA
<213>  Homo sapiens

<400>  159
acaaaacaaa                                                              10

<210>  160
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg 
            500 


<210>  161
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg 
            500     


<210>  162
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr 
            500         


<210>  163
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly 
            500             


<210>  164
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln 
            500                 


<210>  165
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro 
            500                 505 

<210>  166
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  166

Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg 
1               5                   10                  15      


Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu 
            20                  25                  30          


Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp Glu 
        35                  40                  45              


Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp Tyr 
    50                  55                  60                  


Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile Ile 
65                  70                  75                  80  


Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val Phe 
                85                  90                  95      


Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys Leu 
            100                 105                 110         


Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg Tyr 
        115                 120                 125             


Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu Thr 
    130                 135                 140                 


Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn Pro 
145                 150                 155                 160 


Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe Asp 
                165                 170                 175     


Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu Lys 
            180                 185                 190         


Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val 
        195                 200                 205             


Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly 
    210                 215                 220                 


Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu 
225                 230                 235                 240 


Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu Lys 
                245                 250                 255     


Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln Gln 
            260                 265                 270         


His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys Leu 
        275                 280                 285             


Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu Leu 
    290                 295                 300                 


Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe Asp 
305                 310                 315                 320 


Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr Glu 
                325                 330                 335     


Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu Gly 
            340                 345                 350         


Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly Met 
        355                 360                 365             


Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile Gly 
    370                 375                 380                 


Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu Glu 
385                 390                 395                 400 


Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala Gln 
                405                 410                 415     


Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp Asp 
            420                 425                 430         


Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu Leu 
        435                 440                 445             


Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala Ile 
    450                 455                 460                 


Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser Val 
465                 470                 475                 480 


Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu Glu 
                485                 490                 495     


Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505 

<210>  167
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys 
            500                 505  

<210>  168
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile 
            500                 505             


<210>  169
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            500                 505                 
 
<210>  170
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HRS polypeptide

<400>  170

Met Cys Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly 
1               5                   10                  15      


Glu Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile 
            20                  25                  30          


Glu Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro 
        35                  40                  45              


Asp Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60      


<210>  171
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HRS polypeptide

<400>  171

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Cys Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys 
    50                  55                  60  


<210>  172
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine modified HRS polypeptide

<400>  172

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Cys 
    50                  55                  60      


<210>  173
<211>  183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cyteine modified HRS

<400>  173
atgtgtgcag aaagagccgc cctggaagag ttagttaagt tgcaaggtga acgtgtccgt       60

ggtctgaagc agcagaaggc tagcgcggag ctgatcgaag aagaggtggc caaactgctg      120

aagctgaagg cgcagctggg cccggacgag agcaaacaaa agttcgtcct gaaaaccccg      180

aaa                                                                    183


<210>  174
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cyteine modified HRS

<400>  174
atggcagaac gtgcggcatt ggaagaattg gttaaactgc aaggtgaacg tgttcgtggt       60

ctgaagcagc agaagtgcag cgcggagctg atcgaagaag aggtggccaa actgctgaag      120

ctgaaggcgc agctgggccc ggacgagagc aaacaaaagt tcgtcctgaa aaccccgaaa      180


<210>  175
<211>  183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cyteine modified HRS

<400>  175
atggcagaac gtgcggcatt ggaagaattg gttaaactgc aaggtgaacg tgttcgtggt       60

ctgaagcagc agaaggctag cgcggagctg atcgaagaag aggtggccaa actgctgaag      120

ctgaaggcgc agctgggccc ggacgagagc aaacaaaagt tcgtcctgaa aaccccgaaa      180

tgc                                                                    183 

<210>  176
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  176

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Ala Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  177
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  177

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Val Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  178
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  178

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Ala Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  179
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  179

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Ser Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  180
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  180

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Val Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  181
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  181

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Ser 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  182
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cysteine mutated HRS polypeptide

<400>  182

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Ser Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu 
            500                 505     


<210>  183
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  183
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagg ctgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  184
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  184
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagg ttgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  185
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  185
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag gctttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  186
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  186
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag agtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  187
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  187
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag gttttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  188
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  188
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt ccggtgtttc tgattccaaa ttccgtacaa tctgctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518


<210>  189
<211>  1518
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide encoding cysteine mutated HRS protein

<400>  189
atggcggaac gtgccgcact ggaagaattg gttaaattac agggagaacg cgtacgtggt       60

cttaaacaac aaaaagcctc tgcggaattg attgaagaag aagttgccaa attactgaaa      120

ctgaaagctc aacttggacc cgatgaaagt aaacaaaaat ttgtgttgaa aacgcccaaa      180

ggaacccgtg attatagtcc acgtcaaatg gccgttcgtg aaaaagtgtt cgacgttatt      240

attcgctgtt ttaaacgtca cggtgctgaa gtaatcgata cccccgtatt tgaattgaaa      300

gagactctga tgggcaaata tggtgaagat tctaaactga tttatgattt gaaagaccaa      360

ggaggtgaac tgctgagcct gcgctacgac ttaactgtgc cttttgcccg ttacttagcc      420

atgaataaat taaccaacat caaacgttac catattgcaa aagtatatcg ccgcgacaac      480

cctgcaatga ctcgtggacg ctatcgcgaa ttctatcagt gtgattttga tattgccgga      540

aatttcgacc cgatgatccc ggatgccgag tgtttgaaaa ttatgtgtga aattctgagt      600

tcgttgcaga tcggagactt tcttgtaaaa gttaatgacc gccgtattct ggatggtatg      660

tttgctattt gcggtgtttc tgattccaaa ttccgtacaa tctcctcaag cgtggacaaa      720

ttggataaag tgtcttggga agaagtaaaa aatgaaatgg tgggagaaaa aggcctggct      780

ccagaagtag cagaccgtat tggtgactat gttcaacaac atggcggtgt gtccttagtc      840

gaacagttat tacaggatcc taaactgagc caaaataaac aagcacttga aggactggga      900

gatctgaaat tactctttga atatctgacc ttatttggga ttgatgataa aattagcttt      960

gatctgagct tggcccgcgg tcttgattat tataccggcg tgatttacga agctgttctc     1020

ttgcaaaccc cagcccaggc gggcgaagag cctttgggag tcggcagtgt ggcagccggt     1080

ggtcgttatg atggtttggt aggaatgttt gaccctaaag gccgtaaagt accatgtgtg     1140

gggctttcta tcggtgtcga acgtatcttt tctattgttg aacaacgtct tgaagctttg     1200

gaggaaaaga tccgtaccac ggaaacccaa gtcttagttg caagtgccca aaaaaaactg     1260

ttagaagaac gcctgaaact cgtatcagaa ctttgggacg ccggcatcaa ggccgaactg     1320

ctgtataaaa agaacccgaa attgttaaac caactccagt attgtgaaga agctgggatc     1380

ccactcgtag ctattattgg tgagcaagaa ttaaaagatg gcgtgattaa actgcgttca     1440

gtaacaagcc gtgaagaggt agatgtacgt cgcgaagact tagtggaaga aattaaacgc     1500

cgcaccggtc aaccgtta                                                   1518  


<210>  190
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  190

Val Phe Asp Val Ile Ile Arg Cys Phe Lys 
1               5                   10  


<210>  191
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  191

Val Tyr Arg Arg Asp Asn Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu 
1               5                   10                  15      


Phe Tyr Gln Cys Asp Phe Asp Ile Ala Gly Asn Phe Asp Pro Met Ile 
            20                  25                  30          


Pro Asp Ala Glu Cys Leu Lys 
        35                  


<210>  192
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  192

Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu Val 
1               5                   10                  15      


Lys 
    


<210>  193
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  193

Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys Gly Val 
1               5                   10                  15      


Ser Asp Ser Lys 
            20  


<210>  194
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  194

Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
1               5                   10  


<210>  195
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  195

Phe Arg Thr Ile Cys Ser Ser Val Asp Lys Leu Asp Lys 
1               5                   10              


<210>  196
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  196

Val Pro Cys Val Gly Leu Ser Ile Gly Val Glu Arg Ile Phe Ser Ile 
1               5                   10                  15      


Val Glu Gln Arg Leu Glu Ala Leu Glu Glu Lys 
            20                  25          


<210>  197
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  197

Leu Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val 
1               5                   10                  15      


Ala Ile Ile Gly Glu Gln Glu Leu Lys 
            20                  25  


<210>  198
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  198

Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
1               5                   10  


<210>  199
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  199
gtttgacgta atcatccgtt gcttcaagcg ccacggtgca g                           41


<210>  200
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  200
ctgcaccgtg gcgcttgaag caacggatga ttacgtcaaa c                           41


<210>  201
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  201
gccgataccg ggaattctac cagtgtgatt ttgacattgc tggg                        44


<210>  202
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  202
cccagcaatg tcaaaatcac actggtagaa ttcccggtat cggc                        44


<210>  203
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  203
ccatgatccc tgatgcagag tgcctgaaga tcatgtgcga g                           41


<210>  204
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  204
ctcgcacatg atcttcaggc actctgcatc agggatcatg g                           41


<210>  205
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  205
gcagagtgcc tgaagatcat gtgcgagatc ctgagttcac ttc                         43


<210>  206
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  206
gaagtgaact caggatctcg cacatgatct tcaggcactc tgc                         43


<210>  207
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  207
ctagatggga tgtttgctat ctgtggtgtt tctgacagca agttc                       45


<210>  208
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  208
gaacttgctg tcagaaacac cacagatagc aaacatccca tctag                       45


<210>  209
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  209
cagcaagttc cgtaccatct gctcctcagt agacaagctg g                           41


<210>  210
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  210
ccagcttgtc tactgaggag cagatggtac ggaacttgct g                           41


<210>  211
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  211
gggcgcaagg tgccatgtgt ggggctcagc attgggg                                37


<210>  212
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  212
ccccaatgct gagccccaca catggcacct tgcgccc                                37


<210>  213
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  213
ctgaaccagt tacagtactg tgaggaggca ggcatccc                               38


<210>  214
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  214
gggatgcctg cctcctcaca gtactgtaac tggttcag                               38


<210>  215
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  215
gagaacaggc cagcccctct gcatctgcta gaacccagc                              39


<210>  216
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  216
gctgggttct agcagatgca gaggggctgg cctgttctc                              39


<210>  217
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  217
ccagcccctc tgcatctgct agaacccagc tttcttg                                37


<210>  218
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  218
caagaaagct gggttctagc agatgcagag gggctgg                                37


<210>  219
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  219
gaacaggcca gcccctctag aacccagctt tcttg                                  35


<210>  220
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  220
caagaaagct gggttctaga ggggctggcc tgttc                                  35


<210>  221
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  221
cccggatgcc gaggctttga aaattatgtg                                        30


<210>  222
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  222
cacataattt tcaaagcctc ggcatccggg                                        30


<210>  223
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  223
gatcccggat gccgagagtt tgaaaattat gtgtg                                  35


<210>  224
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  224
cacacataat tttcaaactc tcggcatccg ggatc                                  35


<210>  225
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  225
gatcccggat gccgaggttt tgaaaattat gtgtg                                  35


<210>  226
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  226
cacacataat tttcaaaacc tcggcatccg ggatc                                  35


<210>  227
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  227
cgcgaattct atcaggctga ttttgatatt gccgg                                  35


<210>  228
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  228
ccggcaatat caaaatcagc ctgatagaat tcgcg                                  35


<210>  229
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  229
cgcgaattct atcaggttga ttttgatatt gccg                                   34


<210>  230
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  230
cggcaatatc aaaatcaacc tgatagaatt cgcg                                   34


<210>  231
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  231
ggtatgtttg ctatttccgg tgtttctgat tcc                                    33


<210>  232
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  232
ggaatcagaa acaccggaaa tagcaaacat acc                                    33


<210>  233
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  233
ccaaattccg tacaatctcc tcaagcgtgg acaaattgg                              39


<210>  234
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  234
ccaatttgtc cacgcttgag gagattgtac ggaatttgg                              39


<210>  235
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  235
cccggatgcc gaggctttga aaattatgtg                                        30


<210>  236
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer to selectively mutate cysteine residue

<400>  236
cacataattt tcaaagcctc ggcatccggg                                        30

  