                               SEQUENCE LISTING

<110> CYTONICS CORPORATION
 
<120> SYSTEMS, COMPOSITIONS, AND METHODS FOR TRANSPLANTATION

<130> 37151-701.601

<140> PCT/US2013/027159
<141> 2013-02-21

<150> 61/740,218
<151> 2012-12-20

<150> 61/727,433
<151> 2012-11-16

<150> 61/726,840
<151> 2012-11-15

<150> 61/726,815
<151> 2012-11-15

<150> 61/601,434
<151> 2012-02-21

<160> 76    

<170> PatentIn version 3.5

<210> 1
<211> 8993
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
ctcatgacca aaatccctta acgtgagtta cgcgcgcgtc gttccactga gcgtcagacc       60

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct      120

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa      180

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag      240

tgtagccgta gttagcccac cacttcaaga actctgtagc accgcctaca tacctcgctc      300

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg      360

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca      420

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat      480

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg      540

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc      600

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc      660

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc      720

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg      780

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga      840

gcgaggaagc ggaaggcgag agtagggaac tgccaggcat caaactaagc agaaggcccc      900

tgacggatgg cctttttgcg tttctacaaa ctctttctgt gttgtaaaac gacggccagt      960

cttaagctcg ggccccctgg gcggttctga taacgagtaa tcgttaatcc gcaaataacg     1020

taaaaacccg cttcggcggg tttttttatg gggggagttt agggaaagag catttgtcag     1080

aatatttaag ggcgcctgtc actttgcttg atatatgaga attatttaac cttataaatg     1140

agaaaaaagc aacgcacttt aaataagata cgttgctttt tcgattgatg aacacctata     1200

attaaactat tcatctatta tttatgattt tttgtatata caatatttct agtttgttaa     1260

agagaattaa gaaaataaat ctcgaaaata ataaagggaa aatcagtttt tgatatcaaa     1320

attatacatg tcaacgataa tacaaaatat aatacaaact ataagatgtt atcagtattt     1380

attatcattt agaataaatt ttgtgtcgcc cttaattgtg agcggataac aattacgagc     1440

ttcatgcaca gtggcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg     1500

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc     1560

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     1620

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     1680

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     1740

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     1800

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca     1860

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     1920

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     1980

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     2040

ctctctggct aactagagaa cccactgctt actggcttat cgaaattaat acgactcact     2100

ataggggtac ctgccaccat ggggaaaaac aaactgctgc atccaagcct ggtcctgctg     2160

ctgctggttc tgctgcctac tgacgcctct gtgagcggaa agccccagta tatggttctg     2220

gtcccgtccc tgctgcacac cgagaccaca gaaaaagggt gcgtgctgct gtcttacctg     2280

aatgaaacag tgactgttag tgcctcactg gagagtgtgc gcggaaatcg ttcactgttc     2340

accgatctgg aggcggaaaa cgatgtgctg cattgcgtcg catttgctgt gccaaaaagc     2400

tcctctaatg aagaagtgat gttcctgacc gtccaggtga agggccctac acaggaattc     2460

aaaaaacgca ctaccgttat ggtcaaaaac gaggatagcc tggtgtttgt tcagacagac     2520

aaatccatct ataagcctgg tcagactgtg aagttccggg tggttagcat ggatgaaaat     2580

tttcaccccc tgaacgagct gattccactg gtgtacatcc aggaccctaa aggcaaccgc     2640

atcgcccagt ggcagtcttt ccagctggaa ggcggtctga agcagtttag tttccctctg     2700

agttcagagc cgtttcaggg ttcttataaa gtcgtggttc agaaaaagag tgggggacgt     2760

actgaacatc cttttaccgt tgaagagttc gtcctgccga aatttgaggt ccaggtgacc     2820

gttcccaaga ttatcacaat tctggaagag gaaatgaacg tgagcgtgtg cggactgtat     2880

acctacggca aaccagtgcc tggtcacgtt acagtcagta tctgccgtaa gtactcagat     2940

gcaagcgact gtcatggcga agattcacag gctttttgcg agaagttcag cggccagctg     3000

aactcccacg gttgcttcta tcagcaggtg aaaaccaagg tttttcagct gaaacggaag     3060

gagtacgaaa tgaaactgca tacagaagcc cagattcagg aagaaggcac cgtcgtggaa     3120

ctgactggtc gtcagagctc cgagattacc cggacaatca ctaaactgag cttcgtgaag     3180

gttgattccc actttcggca ggggattccc tttttcggac aggtgcgcct ggttgacggg     3240

aaaggagttc cgatccccaa caaagtgatc tttattcgcg gcaatgaagc caactattac     3300

agcaacgcga caactgatga gcatgggctg gtgcagttca gtatcaatac cacaaacgtg     3360

atgggaacct cactgacagt ccgcgtgaat tataaagacc gttcaccgtg ttatggctac     3420

cagtgggtga gcgaggaaca cgaggaagcc caccataccg cgtacctggt tttcagcccc     3480

tccaaatctt ttgtccatct ggaacctatg tctcacgagc tgccgtgcgg ccatacccag     3540

acagtgcagg cacattatat tctgaacggc ggcaccctgc tgggtctgaa aaagctgagc     3600

ttttattacc tgattatggc taagggggga atcgtccgca ctggcaccca cggtctgctg     3660

gttaaacagg aagatatgaa gggccatttc agtatttcaa tccctgttaa aagcgacatt     3720

gctccggtcg cccgtctgct gatctatgcc gtgctgccaa ccggcgatgt tatcggtgac     3780

tccgccaaat acgatgtgga gaattgtctg gcgaacaagg ttgacctgag cttttccccc     3840

tctcagagtc tgccagcgtc tcatgcacat ctgcgtgtga ccgcagcccc tcagagcgtt     3900

tgcgctctgc gtgcagtgga tcagtccgtg ctgctgatga agccagacgc agaactgtct     3960

gctagcagcg tgtataatct gctgcctgag aaagatctga ccgggttccc aggacctctg     4020

aacgatcagg atgacgaaga ctgtattaat cgccacaacg tgtatattaa tgggatcaca     4080

tacactccgg tttcaagcac caacgaaaaa gatatgtaca gcttcctgga ggacatgggt     4140

ctgaaagcgt ttaccaattc caagatccgg aaacccaaga tgtgcccaca gctgcagcag     4200

tatgaaatgc acggacctga gggtctgcgt gtgggctttt acgaatctga tgtgatggga     4260

cgtggtcatg cacgtctggt tcatgtcgag gaaccacaca ccgaaacagt gcgtaaatac     4320

ttccctgaga cctggatttg ggacctggtt gtggtgaact ccgcgggtgt ggcagaagtg     4380

ggtgttaccg tcccggatac tattaccgaa tggaaagcag gtgccttctg tctgtctgag     4440

gatgcagggc tgggaatctc ctctacagcc tctctgcgcg cgtttcagcc ctttttcgtc     4500

gaactgacta tgccatatag cgtgattcgt ggcgaggcat tcactctgaa agctaccgtg     4560

ctgaattacc tgcccaagtg catccgcgtg agcgtgcagc tggaagctag tcccgccttt     4620

ctggcggtcc cagtggagaa ggaacaggca ccgcactgca tttgtgctaa cggccggcag     4680

actgtttcct gggccgtcac ccccaaatct ctgggtaatg tgaacttcac cgtttcagca     4740

gaggctctgg aaagccagga gctgtgcggc accgaagtcc catccgtgcc tgagcatggt     4800

cgcaaagata cagtcatcaa gcctctgctg gttgaaccgg aaggcctgga gaaggaaact     4860

acctttaatt ctctgctgtg cccaagtggc ggtgaagtgt ccgaggaact gtctctgaaa     4920

ctgccgccca acgtggtcga ggaatctgcc cgtgcgtcag ttagcgtcct gggggatatt     4980

ctgggaagtg ccatgcagaa tacccagaac ctgctgcaga tgccgtatgg ctgtggcgag     5040

cagaatatgg ttctgtttgc gcccaacatc tatgtcctgg attacctgaa tgaaacacag     5100

cagctgactc ctgaaatcaa aagcaaggca atcgggtatc tgaataccgg ataccagcgg     5160

cagctgaact ataagcacta cgacggctcc tattctacct tcggcgaacg gtacggtcgc     5220

aatcagggga acacttggct gaccgccttt gtgctgaaaa cctttgccca ggctcgcgcc     5280

tatatcttta ttgatgaggc ccatattaca caggcgctga tctggctgtc acagcgccag     5340

aaggacaacg ggtgtttccg tagttcagga agcctgctga acaatgccat caaaggcggc     5400

gtcgaggatg aagtgacact gagcgcatac attactatcg ctctgctgga aatccctctg     5460

acagtgactc acccggtggt tcgcaatgct ctgttttgcc tggaaagtgc atggaaaaca     5520

gctcaggaag gcgatcacgg atcacacgtg tatactaagg cactgctggc gtacgcattc     5580

gctctggccg gcaaccagga taaacgtaaa gaagtgctga aatcactgaa tgaggaagca     5640

gttaaaaagg acaacagcgt ccactgggaa cggccgcaga aacccaaggc tccagtgggt     5700

cacttttatg agcctcaggc accgagtgct gaggtggaaa tgacctcata tgttctgctg     5760

gcatacctga ccgcacagcc tgcccccaca tcagaagatc tgacaagcgc cactaatatt     5820

gtgaaatgga tcaccaagca gcagaacgcg cagggcggtt ttagctccac ccaggacaca     5880

gtcgtggcac tgcacgctct gtctaaatat ggggcagcta ccttcacacg cactggaaag     5940

gccgcgcaag tgactattca gtctagtggc accttttcaa gcaagttcca ggtggataac     6000

aataaccgtc tgctgctgca gcaggtgtcc ctgcccgaac tgccaggcga gtactctatg     6060

aaagtcactg gggaaggatg cgtgtatctg cagacctccc tgaaatacaa tattctgccc     6120

gagaaagaag aatttccatt cgcactgggc gtgcagaccc tgcctcagac atgcgatgaa     6180

ccgaaggctc atacttcttt tcagatcagt ctgtcagtga gctataccgg gtcccgctct     6240

gccagtaaca tggcgattgt ggatgtgaaa atggtgagtg gattcatccc tctgaaaccg     6300

actgtgaaga tgctggaacg gagtaatcac gtttcacgca ccgaggtctc ctctaaccat     6360

gtgctgatct acctggataa agtgtccaat cagacactgt ctctgttttt cactgtgctg     6420

caggatgtcc ccgtgcgtga cctgaaacca gccattgtta aggtctatga ttattacgaa     6480

accgacgagt tcgcgatcgc agaatacaac gcgccgtgca gcaaagacct ggggaatgct     6540

gactacaagg acgacgacga caagggggca agccaccacc atcaccatca ctaaggatcc     6600

aaaatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt     6660

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat     6720

tgcatcacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg     6780

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattaattc     6840

tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg ctccccagca ggcagaagta     6900

tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag     6960

caggcagaag tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa     7020

ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc catggctgac     7080

taattttttt tatttatgca gaggccgagg ccgcctctgc ctctgagcta ttccagaagt     7140

agtgaggagg cttttttgga ggcctaggct tttgcaaaaa gctcccggga gcttgtatat     7200

ccattttcgg atctgatcag cacgtgttga caattaatca tcggcatagt atatcggcat     7260

agtataatac gacaaggtga ggaactaaac catggccaag cctttgtctc aagaagaatc     7320

caccctcatt gaaagagcaa cggctacaat caacagcatc cccatctctg aagactacag     7380

cgtcgccagc gcagctctct ctagcgacgg ccgcatcttc actggtgtca atgtatatca     7440

ttttactggg ggaccttgtg cagaactcgt ggtgctgggc actgctgctg ctgcggcagc     7500

tggcaacctg acttgtatcg tcgcgatcgg aaatgagaac aggggcatct tgagcccctg     7560

cggacggtgc cgacaggtgc ttctcgatct gcatcctggg atcaaagcca tagtgaagga     7620

cagtgatgga cagccgacgg cagttgggat tcgtgaattg ctgccctctg gttatgtgtg     7680

ggagggctaa cacgtgctac gagatttcga ttccaccgcc gccttctatg aaaggttggg     7740

cttcggaatc gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct     7800

ggagttcttc gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa     7860

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     7920

caaactcatc aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc     7980

gtaatcatgg tcattaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     8040

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     8100

taccatctgg ccccagcgct gcgatgatac cgcgagaacc acgctcaccg gctccggatt     8160

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     8220

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     8280

atagtttgcg caacgttgtt gccatcgcta caggcatcgt ggtgtcacgc tcgtcgtttg     8340

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     8400

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     8460

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     8520

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     8580

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     8640

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     8700

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt     8760

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     8820

gaataagggc gacacggaaa tgttgaatac tcatattctt cctttttcaa tattattgaa     8880

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     8940

aacaaatagg ggtcagtgtt acaaccaatt aaccaattct gaacattatc gcg            8993


<210> 2
<211> 8994
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
ctcatgacca aaatccctta acgtgagtta cgcgcgcgtc gttccactga gcgtcagacc       60

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct      120

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa      180

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag      240

tgtagccgta gttagcccac cacttcaaga actctgtagc accgcctaca tacctcgctc      300

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg      360

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca      420

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat      480

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg      540

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc      600

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc      660

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc      720

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg      780

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga      840

gcgaggaagc ggaaggcgag agtagggaac tgccaggcat caaactaagc agaaggcccc      900

tgacggatgg cctttttgcg tttctacaaa ctctttctgt gttgtaaaac gacggccagt      960

cttaagctcg ggccccctgg gcggttctga taacgagtaa tcgttaatcc gcaaataacg     1020

taaaaacccg cttcggcggg tttttttatg gggggagttt agggaaagag catttgtcag     1080

aatatttaag ggcgcctgtc actttgcttg atatatgaga attatttaac cttataaatg     1140

agaaaaaagc aacgcacttt aaataagata cgttgctttt tcgattgatg aacacctata     1200

attaaactat tcatctatta tttatgattt tttgtatata caatatttct agtttgttaa     1260

agagaattaa gaaaataaat ctcgaaaata ataaagggaa aatcagtttt tgatatcaaa     1320

attatacatg tcaacgataa tacaaaatat aatacaaact ataagatgtt atcagtattt     1380

attatcattt agaataaatt ttgtgtcgcc cttaattgtg agcggataac aattacgagc     1440

ttcatgcaca gtggcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg     1500

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc     1560

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca     1620

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg     1680

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg     1740

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt     1800

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca     1860

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     1920

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     1980

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     2040

ctctctggct aactagagaa cccactgctt actggcttat cgaaattaat acgactcact     2100

ataggggtac ctgccaccat ggggaaaaac aaactgctgc atccaagcct ggtcctgctg     2160

ctgctggttc tgctgcctac tgacgcctct gtgagcggaa agccccagta tatggttctg     2220

gtcccgtccc tgctgcacac cgagaccaca gaaaaagggt gcgtgctgct gtcttacctg     2280

aatgaaacag tgactgttag tgcctcactg gagagtgtgc gcggaaatcg ttcactgttc     2340

accgatctgg aggcggaaaa cgatgtgctg cattgcgtcg catttgctgt gccaaaaagc     2400

tcctctaatg aagaagtgat gttcctgacc gtccaggtga agggccctac acaggaattc     2460

aaaaaacgca ctaccgttat ggtcaaaaac gaggatagcc tggtgtttgt tcagacagac     2520

aaatccatct ataagcctgg tcagactgtg aagttccggg tggttagcat ggatgaaaat     2580

tttcaccccc tgaacgagct gattccactg gtgtacatcc aggaccctaa aggcaaccgc     2640

atcgcccagt ggcagtcttt ccagctggaa ggcggtctga agcagtttag tttccctctg     2700

agttcagagc cgtttcaggg ttcttataaa gtcgtggttc agaaaaagag tgggggacgt     2760

actgaacatc cttttaccgt tgaagagttc gtcctgccga aatttgaggt ccaggtgacc     2820

gttcccaaga ttatcacaat tctggaagag gaaatgaacg tgagcgtgtg cggactgtat     2880

acctacggca aaccagtgcc tggtcacgtt acagtcagta tctgccgtaa gtactcagat     2940

gcaagcgact gtcatggcga agattcacag gctttttgcg agaagttcag cggccagctg     3000

aactcccacg gttgcttcta tcagcaggtg aaaaccaagg tttttcagct gaaacggaag     3060

gagtacgaaa tgaaactgca tacagaagcc cagattcagg aagaaggcac cgtcgtggaa     3120

ctgactggtc gtcagagctc cgagattacc cggacaatca ctaaactgag cttcgtgaag     3180

gttgattccc actttcggca ggggattccc tttttcggac aggtgcgcct ggttgacggg     3240

aaaggagttc cgatccccaa caaagtgatc tttattcgcg gcaatgaagc caactattac     3300

agcaacgcga caactgatga gcatgggctg gtgcagttca gtatcaatac cacaaacgtg     3360

atgggaacct cactgacagt ccgcgtgaat tataaagacc gttcaccgtg ttatggctac     3420

cagtgggtga gcgaggaaca cgaggaagcc caccataccg cgtacctggt tttcagcccc     3480

tccaaatctt ttgtccatct ggaacctatg tctcacgagc tgccgtgcgg ccatacccag     3540

acagtgcagg cacattatat tctgaacggc ggcaccctgc tgggtctgaa aaagctgagc     3600

ttttattacc tgattatggc taagggggga atcgtccgca ctggcaccca cggtctgctg     3660

gttaaacagg aagatatgaa gggccatttc agtatttcaa tccctgttaa aagcgacatt     3720

gctccggtcg cccgtctgct gatctatgcc gtgctgccaa ccggcgatgt tatcggtgac     3780

tccgccaaat acgatgtgga gaattgtctg gcgaacaagg ttgacctgag cttttccccc     3840

tctcagagtc tgccagcgtc tcatgcacat ctgcgtgtga ccgcagcccc tcagagcgtt     3900

tgcgctctgc gtgcagtgga tcagtccgtg ctgctgatga agccagacgc agaactgtct     3960

gctagcagcg tgtataatct gctgcctgag aaagatctga ccgggttccc aggacctctg     4020

aacgatcagg atgacgaaga ctgtattaat cgccacaacg tgtatattaa tgggatcaca     4080

tacactccgg tttcaagcac caacgaaaaa gatatgtaca gcttcctgga ggacatgggt     4140

ctgaaagcgt ttaccaattc caagatccgg aaaccccaag atgtgcccac agctcgagca     4200

gtatgaaatg cacggacctg agggtctgcg tgtgggcttt tacgaatctg atgtgatggg     4260

acgtggtcat gcacgtctgg ttcatgtcga ggaaccacac accgaaaagc ttcgtaaata     4320

cttccctgag acctggattt gggacctggt tgtggtgaac tccgcgggtg tggcagaagt     4380

gggtgttacc gtcccggata ctattaccga atggaaagca ggtgccttct gtctgtctga     4440

ggatgcaggg ctgggaatct cctctacagc ctctctgcgc gcgtttcagc cctttttcgt     4500

cgaactgact atgccatata gcgtgattcg tggcgaggca ttcactctga aagctaccgt     4560

gctgaattac ctgcccaagt gcatccgcgt gagcgtgcag ctggaagcta gtcccgcctt     4620

tctggcggtc ccagtggaga aggaacaggc accgcactgc atttgtgcta acggccggca     4680

gactgtttcc tgggccgtca cccccaaatc tctgggtaat gtgaacttca ccgtttcagc     4740

agaggctctg gaaagccagg agctgtgcgg caccgaagtc ccatccgtgc ctgagcatgg     4800

tcgcaaagat acagtcatca agcctctgct ggttgaaccg gaaggcctgg agaaggaaac     4860

tacctttaat tctctgctgt gcccaagtgg cggtgaagtg tccgaggaac tgtctctgaa     4920

actgccgccc aacgtggtcg aggaatctgc ccgtgcgtca gttagcgtcc tgggggatat     4980

tctgggaagt gccatgcaga atacccagaa cctgctgcag atgccgtatg gctgtggcga     5040

gcagaatatg gttctgtttg cgcccaacat ctatgtcctg gattacctga atgaaacaca     5100

gcagctgact cctgaaatca aaagcaaggc aatcgggtat ctgaataccg gataccagcg     5160

gcagctgaac tataagcact acgacggctc ctattctacc ttcggcgaac ggtacggtcg     5220

caatcagggg aacacttggc tgaccgcctt tgtgctgaaa acctttgccc aggctcgcgc     5280

ctatatcttt attgatgagg cccatattac acaggcgctg atctggctgt cacagcgcca     5340

gaaggacaac gggtgtttcc gtagttcagg aagcctgctg aacaatgcca tcaaaggcgg     5400

cgtcgaggat gaagtgacac tgagcgcata cattactatc gctctgctgg aaatccctct     5460

gacagtgact cacccggtgg ttcgcaatgc tctgttttgc ctggaaagtg catggaaaac     5520

agctcaggaa ggcgatcacg gatcacacgt gtatactaag gcactgctgg cgtacgcatt     5580

cgctctggcc ggcaaccagg ataaacgtaa agaagtgctg aaatcactga atgaggaagc     5640

agttaaaaag gacaacagcg tccactggga acggccgcag aaacccaagg ctccagtggg     5700

tcacttttat gagcctcagg caccgagtgc tgaggtggaa atgacctcat atgttctgct     5760

ggcatacctg accgcacagc ctgcccccac atcagaagat ctgacaagcg ccactaatat     5820

tgtgaaatgg atcaccaagc agcagaacgc gcagggcggt tttagctcca cccaggacac     5880

agtcgtggca ctgcacgctc tgtctaaata tggggcagct accttcacac gcactggaaa     5940

ggccgcgcaa gtgactattc agtctagtgg caccttttca agcaagttcc aggtggataa     6000

caataaccgt ctgctgctgc agcaggtgtc cctgcccgaa ctgccaggcg agtactctat     6060

gaaagtcact ggggaaggat gcgtgtatct gcagacctcc ctgaaataca atattctgcc     6120

cgagaaagaa gaatttccat tcgcactggg cgtgcagacc ctgcctcaga catgcgatga     6180

accgaaggct catacttctt ttcagatcag tctgtcagtg agctataccg ggtcccgctc     6240

tgccagtaac atggcgattg tggatgtgaa aatggtgagt ggattcatcc ctctgaaacc     6300

gactgtgaag atgctggaac ggagtaatca cgtttcacgc accgaggtct cctctaacca     6360

tgtgctgatc tacctggata aagtgtccaa tcagacactg tctctgtttt tcactgtgct     6420

gcaggatgtc cccgtgcgtg acctgaaacc agccattgtt aaggtctatg attattacga     6480

aaccgacgag ttcgcgatcg cagaatacaa cgcgccgtgc agcaaagacc tggggaatgc     6540

tgactacaag gacgacgacg acaagggggc aagccaccac catcaccatc actaaggatc     6600

caaaatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg     6660

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa     6720

ttgcatcaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     6780

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt     6840

ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt     6900

atgcaaagca tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca     6960

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta     7020

actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga     7080

ctaatttttt ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag     7140

tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata     7200

tccattttcg gatctgatca gcacgtgttg acaattaatc atcggcatag tatatcggca     7260

tagtataata cgacaaggtg aggaactaaa ccatggccaa gcctttgtct caagaagaat     7320

ccaccctcat tgaaagagca acggctacaa tcaacagcat ccccatctct gaagactaca     7380

gcgtcgccag cgcagctctc tctagcgacg gccgcatctt cactggtgtc aatgtatatc     7440

attttactgg gggaccttgt gcagaactcg tggtgctggg cactgctgct gctgcggcag     7500

ctggcaacct gacttgtatc gtcgcgatcg gaaatgagaa caggggcatc ttgagcccct     7560

gcggacggtg ccgacaggtg cttctcgatc tgcatcctgg gatcaaagcc atagtgaagg     7620

acagtgatgg acagccgacg gcagttggga ttcgtgaatt gctgccctct ggttatgtgt     7680

gggagggcta acacgtgcta cgagatttcg attccaccgc cgccttctat gaaaggttgg     7740

gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc     7800

tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca     7860

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt     7920

ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg     7980

cgtaatcatg gtcattacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     8040

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     8100

ttaccatctg gccccagcgc tgcgatgata ccgcgagaac cacgctcacc ggctccggat     8160

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     8220

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     8280

aatagtttgc gcaacgttgt tgccatcgct acaggcatcg tggtgtcacg ctcgtcgttt     8340

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     8400

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     8460

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     8520

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     8580

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     8640

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     8700

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     8760

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     8820

ggaataaggg cgacacggaa atgttgaata ctcatattct tcctttttca atattattga     8880

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     8940

aaacaaatag gggtcagtgt tacaaccaat taaccaattc tgaacattat cgcg           8994


<210> 3
<211> 1491
<212> PRT
<213> Homo sapiens


<220>
<223>  Tagged wild-type human A2M polypeptide

<400> 3
Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                405                 410                 415     


Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asp Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                645                 650                 655     


Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Thr Glu Thr Val Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Thr Gln Gln Leu Thr Pro Glu Ile  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Thr  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Thr Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Thr Trp  Leu Thr Ala Phe Val  Leu Lys Thr Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Thr Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Thr  Leu Ser Ala Tyr Ile  Thr Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Thr  Val Thr His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Thr Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Thr Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Thr Ser  Tyr Val Leu Leu Ala  Tyr Leu Thr 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Thr Ser  Glu Asp Leu Thr Ser  Ala Thr Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Thr Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Thr Gln Asp Thr Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Thr Phe Thr  Arg Thr Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Thr Ile  Gln Ser Ser Gly Thr  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Thr Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Thr Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Thr Leu Pro Gln  Thr Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Thr Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Thr  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Thr  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Thr Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Thr Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Thr Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Thr  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala Asp  Tyr Lys Asp Asp Asp  Asp Lys Gly Ala Ser  His His His 
    1475                 1480                 1485             


His His  His 
    1490     


<210> 4
<211> 1491
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Gly Lys Asn Lys Leu Leu His Pro Ser Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Pro Thr Asp Ala Ser Val Ser Gly Lys Pro Gln Tyr Met 
            20                  25                  30          


Val Leu Val Pro Ser Leu Leu His Thr Glu Thr Thr Glu Lys Gly Cys 
        35                  40                  45              


Val Leu Leu Ser Tyr Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu 
    50                  55                  60                  


Glu Ser Val Arg Gly Asn Arg Ser Leu Phe Thr Asp Leu Glu Ala Glu 
65                  70                  75                  80  


Asn Asp Val Leu His Cys Val Ala Phe Ala Val Pro Lys Ser Ser Ser 
                85                  90                  95      


Asn Glu Glu Val Met Phe Leu Thr Val Gln Val Lys Gly Pro Thr Gln 
            100                 105                 110         


Glu Phe Lys Lys Arg Thr Thr Val Met Val Lys Asn Glu Asp Ser Leu 
        115                 120                 125             


Val Phe Val Gln Thr Asp Lys Ser Ile Tyr Lys Pro Gly Gln Thr Val 
    130                 135                 140                 


Lys Phe Arg Val Val Ser Met Asp Glu Asn Phe His Pro Leu Asn Glu 
145                 150                 155                 160 


Leu Ile Pro Leu Val Tyr Ile Gln Asp Pro Lys Gly Asn Arg Ile Ala 
                165                 170                 175     


Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly Leu Lys Gln Phe Ser Phe 
            180                 185                 190         


Pro Leu Ser Ser Glu Pro Phe Gln Gly Ser Tyr Lys Val Val Val Gln 
        195                 200                 205             


Lys Lys Ser Gly Gly Arg Thr Glu His Pro Phe Thr Val Glu Glu Phe 
    210                 215                 220                 


Val Leu Pro Lys Phe Glu Val Gln Val Thr Val Pro Lys Ile Ile Thr 
225                 230                 235                 240 


Ile Leu Glu Glu Glu Met Asn Val Ser Val Cys Gly Leu Tyr Thr Tyr 
                245                 250                 255     


Gly Lys Pro Val Pro Gly His Val Thr Val Ser Ile Cys Arg Lys Tyr 
            260                 265                 270         


Ser Asp Ala Ser Asp Cys His Gly Glu Asp Ser Gln Ala Phe Cys Glu 
        275                 280                 285             


Lys Phe Ser Gly Gln Leu Asn Ser His Gly Cys Phe Tyr Gln Gln Val 
    290                 295                 300                 


Lys Thr Lys Val Phe Gln Leu Lys Arg Lys Glu Tyr Glu Met Lys Leu 
305                 310                 315                 320 


His Thr Glu Ala Gln Ile Gln Glu Glu Gly Thr Val Val Glu Leu Thr 
                325                 330                 335     


Gly Arg Gln Ser Ser Glu Ile Thr Arg Thr Ile Thr Lys Leu Ser Phe 
            340                 345                 350         


Val Lys Val Asp Ser His Phe Arg Gln Gly Ile Pro Phe Phe Gly Gln 
        355                 360                 365             


Val Arg Leu Val Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Val Ile 
    370                 375                 380                 


Phe Ile Arg Gly Asn Glu Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asp 
385                 390                 395                 400 


Glu His Gly Leu Val Gln Phe Ser Ile Asn Thr Thr Asn Val Met Gly 
                405                 410                 415     


Thr Ser Leu Thr Val Arg Val Asn Tyr Lys Asp Arg Ser Pro Cys Tyr 
            420                 425                 430         


Gly Tyr Gln Trp Val Ser Glu Glu His Glu Glu Ala His His Thr Ala 
        435                 440                 445             


Tyr Leu Val Phe Ser Pro Ser Lys Ser Phe Val His Leu Glu Pro Met 
    450                 455                 460                 


Ser His Glu Leu Pro Cys Gly His Thr Gln Thr Val Gln Ala His Tyr 
465                 470                 475                 480 


Ile Leu Asn Gly Gly Thr Leu Leu Gly Leu Lys Lys Leu Ser Phe Tyr 
                485                 490                 495     


Tyr Leu Ile Met Ala Lys Gly Gly Ile Val Arg Thr Gly Thr His Gly 
            500                 505                 510         


Leu Leu Val Lys Gln Glu Asp Met Lys Gly His Phe Ser Ile Ser Ile 
        515                 520                 525             


Pro Val Lys Ser Asp Ile Ala Pro Val Ala Arg Leu Leu Ile Tyr Ala 
    530                 535                 540                 


Val Leu Pro Thr Gly Asp Val Ile Gly Asp Ser Ala Lys Tyr Asp Val 
545                 550                 555                 560 


Glu Asn Cys Leu Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ser Gln 
                565                 570                 575     


Ser Leu Pro Ala Ser His Ala His Leu Arg Val Thr Ala Ala Pro Gln 
            580                 585                 590         


Ser Val Cys Ala Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys 
        595                 600                 605             


Pro Asp Ala Glu Leu Ser Ala Ser Ser Val Tyr Asn Leu Leu Pro Glu 
    610                 615                 620                 


Lys Asp Leu Thr Gly Phe Pro Gly Pro Leu Asn Asp Gln Asp Asp Glu 
625                 630                 635                 640 


Asp Cys Ile Asn Arg His Asn Val Tyr Ile Asn Gly Ile Thr Tyr Thr 
                645                 650                 655     


Pro Val Ser Ser Thr Asn Glu Lys Asp Met Tyr Ser Phe Leu Glu Asp 
            660                 665                 670         


Met Gly Leu Lys Ala Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Met 
        675                 680                 685             


Cys Pro Gln Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg 
    690                 695                 700                 


Val Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His Ala Arg Leu 
705                 710                 715                 720 


Val His Val Glu Glu Pro His Thr Glu Lys Leu Arg Lys Tyr Phe Pro 
                725                 730                 735     


Glu Thr Trp Ile Trp Asp Leu Val Val Val Asn Ser Ala Gly Val Ala 
            740                 745                 750         


Glu Val Gly Val Thr Val Pro Asp Thr Ile Thr Glu Trp Lys Ala Gly 
        755                 760                 765             


Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu Gly Ile Ser Ser Thr Ala 
    770                 775                 780                 


Ser Leu Arg Ala Phe Gln Pro Phe Phe Val Glu Leu Thr Met Pro Tyr 
785                 790                 795                 800 


Ser Val Ile Arg Gly Glu Ala Phe Thr Leu Lys Ala Thr Val Leu Asn 
                805                 810                 815     


Tyr Leu Pro Lys Cys Ile Arg Val Ser Val Gln Leu Glu Ala Ser Pro 
            820                 825                 830         


Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys Ile 
        835                 840                 845             


Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys Ser 
    850                 855                 860                 


Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser Gln 
865                 870                 875                 880 


Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg Lys 
                885                 890                 895     


Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu Lys 
            900                 905                 910         


Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val Ser 
        915                 920                 925             


Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser Ala 
    930                 935                 940                 


Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met Gln 
945                 950                 955                 960 


Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln Asn 
                965                 970                 975     


Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn Glu 
            980                 985                 990         


Thr Gln Gln Leu Thr Pro Glu Ile  Lys Ser Lys Ala Ile  Gly Tyr Leu 
        995                 1000                 1005             


Asn Thr  Gly Tyr Gln Arg Gln  Leu Asn Tyr Lys His  Tyr Asp Gly 
    1010                 1015                 1020             


Ser Tyr  Ser Thr Phe Gly Glu  Arg Tyr Gly Arg Asn  Gln Gly Asn 
    1025                 1030                 1035             


Thr Trp  Leu Thr Ala Phe Val  Leu Lys Thr Phe Ala  Gln Ala Arg 
    1040                 1045                 1050             


Ala Tyr  Ile Phe Ile Asp Glu  Ala His Ile Thr Gln  Ala Leu Ile 
    1055                 1060                 1065             


Trp Leu  Ser Gln Arg Gln Lys  Asp Asn Gly Cys Phe  Arg Ser Ser 
    1070                 1075                 1080             


Gly Ser  Leu Leu Asn Asn Ala  Ile Lys Gly Gly Val  Glu Asp Glu 
    1085                 1090                 1095             


Val Thr  Leu Ser Ala Tyr Ile  Thr Ile Ala Leu Leu  Glu Ile Pro 
    1100                 1105                 1110             


Leu Thr  Val Thr His Pro Val  Val Arg Asn Ala Leu  Phe Cys Leu 
    1115                 1120                 1125             


Glu Ser  Ala Trp Lys Thr Ala  Gln Glu Gly Asp His  Gly Ser His 
    1130                 1135                 1140             


Val Tyr  Thr Lys Ala Leu Leu  Ala Tyr Ala Phe Ala  Leu Ala Gly 
    1145                 1150                 1155             


Asn Gln  Asp Lys Arg Lys Glu  Val Leu Lys Ser Leu  Asn Glu Glu 
    1160                 1165                 1170             


Ala Val  Lys Lys Asp Asn Ser  Val His Trp Glu Arg  Pro Gln Lys 
    1175                 1180                 1185             


Pro Lys  Ala Pro Val Gly His  Phe Tyr Glu Pro Gln  Ala Pro Ser 
    1190                 1195                 1200             


Ala Glu  Val Glu Met Thr Ser  Tyr Val Leu Leu Ala  Tyr Leu Thr 
    1205                 1210                 1215             


Ala Gln  Pro Ala Pro Thr Ser  Glu Asp Leu Thr Ser  Ala Thr Asn 
    1220                 1225                 1230             


Ile Val  Lys Trp Ile Thr Lys  Gln Gln Asn Ala Gln  Gly Gly Phe 
    1235                 1240                 1245             


Ser Ser  Thr Gln Asp Thr Val  Val Ala Leu His Ala  Leu Ser Lys 
    1250                 1255                 1260             


Tyr Gly  Ala Ala Thr Phe Thr  Arg Thr Gly Lys Ala  Ala Gln Val 
    1265                 1270                 1275             


Thr Ile  Gln Ser Ser Gly Thr  Phe Ser Ser Lys Phe  Gln Val Asp 
    1280                 1285                 1290             


Asn Asn  Asn Arg Leu Leu Leu  Gln Gln Val Ser Leu  Pro Glu Leu 
    1295                 1300                 1305             


Pro Gly  Glu Tyr Ser Met Lys  Val Thr Gly Glu Gly  Cys Val Tyr 
    1310                 1315                 1320             


Leu Gln  Thr Ser Leu Lys Tyr  Asn Ile Leu Pro Glu  Lys Glu Glu 
    1325                 1330                 1335             


Phe Pro  Phe Ala Leu Gly Val  Gln Thr Leu Pro Gln  Thr Cys Asp 
    1340                 1345                 1350             


Glu Pro  Lys Ala His Thr Ser  Phe Gln Ile Ser Leu  Ser Val Ser 
    1355                 1360                 1365             


Tyr Thr  Gly Ser Arg Ser Ala  Ser Asn Met Ala Ile  Val Asp Val 
    1370                 1375                 1380             


Lys Met  Val Ser Gly Phe Ile  Pro Leu Lys Pro Thr  Val Lys Met 
    1385                 1390                 1395             


Leu Glu  Arg Ser Asn His Val  Ser Arg Thr Glu Val  Ser Ser Asn 
    1400                 1405                 1410             


His Val  Leu Ile Tyr Leu Asp  Lys Val Ser Asn Gln  Thr Leu Ser 
    1415                 1420                 1425             


Leu Phe  Phe Thr Val Leu Gln  Asp Val Pro Val Arg  Asp Leu Lys 
    1430                 1435                 1440             


Pro Ala  Ile Val Lys Val Tyr  Asp Tyr Tyr Glu Thr  Asp Glu Phe 
    1445                 1450                 1455             


Ala Ile  Ala Glu Tyr Asn Ala  Pro Cys Ser Lys Asp  Leu Gly Asn 
    1460                 1465                 1470             


Ala Asp  Tyr Lys Asp Asp Asp  Asp Lys Gly Ala Ser  His His His 
    1475                 1480                 1485             


His His  His 
    1490     


<210> 5
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Lys 
1               5                   10                  15      


Glu Glu Glu Gly Leu Gly Ser Ile Pro Glu Asn Phe Phe Gly Val Ser 
            20                  25                  30          


Glu Leu Glu Gly Arg Gly Ser Lys Leu 
        35                  40      


<210> 6
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Ile 
1               5                   10                  15      


Pro Glu Asn Phe Phe Gly Val Ser Glu Leu Glu Gly Arg Gly Ser Lys 
            20                  25                  30          


Glu Glu Glu Gly Leu Gly Ser Lys Leu 
        35                  40      


<210> 7
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Ser 
1               5                   10                  15      


Glu Leu Glu Gly Arg Gly Ser Lys Glu Glu Glu Gly Leu Gly Ser Ile 
            20                  25                  30          


Pro Glu Asn Phe Phe Gly Val Lys Leu 
        35                  40      


<210> 8
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Lys 
1               5                   10                  15      


Glu Glu Glu Gly Leu Gly Ser Ser Glu Leu Glu Gly Arg Gly Ser Thr 
            20                  25                  30          


Ala Gln Glu Ala Gly Glu Gly Lys Leu 
        35                  40      


<210> 9
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Ile 
1               5                   10                  15      


Pro Glu Asn Phe Phe Gly Val Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 10
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Lys 
1               5                   10                  15      


Glu Glu Glu Gly Leu Gly Ser Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 11
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Ser 
1               5                   10                  15      


Glu Leu Glu Gly Arg Gly Ser Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 12
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Glu 
1               5                   10                  15      


Ala Ile Pro Met Ser Ile Pro Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 13
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Thr 
1               5                   10                  15      


Ala Gln Glu Ala Gly Glu Gly Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 14
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Val 
1               5                   10                  15      


Ser Gln Glu Leu Gly Gln Arg Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 15
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Thr 
1               5                   10                  15      


Glu Gly Glu Ala Arg Gly Ser Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 16
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Thr 
1               5                   10                  15      


Ser Glu Asp Leu Val Val Gln Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 17
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Glu 
1               5                   10                  15      


Gly Glu Gly Glu Gly Glu Gly Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 18
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Gly 
1               5                   10                  15      


Glu Glu Gly Val Glu Glu Gly Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 19
<211> 46
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Gly 
1               5                   10                  15      


Ala Arg Gly Leu Glu Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly 
            20                  25                  30          


His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu 
        35                  40                  45      


<210> 20
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Gly 
1               5                   10                  15      


Pro Pro Gly Leu Ala Pro Gly Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 21
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Gly 
1               5                   10                  15      


Glu Pro Glu Gly Ala Lys Gly Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 22
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Glu 
1               5                   10                  15      


Glu Glu Gly Gly Gly Phe Tyr Glu Ser Asp Val Met Gly Arg Gly His 
            20                  25                  30          


Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu 
        35                  40                  45  


<210> 23
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Gly 
1               5                   10                  15      


Tyr Pro Gly Ser Ser Arg Gly Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu Leu 
        35                  40                  45              


<210> 24
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Gly 
1               5                   10                  15      


Ala Arg Gly Leu Glu Gly Gly Phe Ala Gly Leu Pro Asn Gly Gly Glu 
            20                  25                  30          


Glu Gly Val Glu Glu Gly Lys Leu 
        35                  40  


<210> 25
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Glu 
1               5                   10                  15      


Ser Glu Ser Glu Gly Gly Gly Gly Gly Ser Leu Leu Gly Glu Phe Glu 
            20                  25                  30          


Val Glu Gly Gly Phe Ala Gly Leu Pro Asn Gly Lys Leu 
        35                  40                  45  


<210> 26
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Gly 
1               5                   10                  15      


Phe Lys Glu Gly Val Glu Gly Glu Ile Glu Glu Gly Gly Gly Phe Lys 
            20                  25                  30          


Glu Gly Val Glu Gly Lys Leu 
        35                  


<210> 27
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Glu 
1               5                   10                  15      


Ser Glu Ser Glu Gly Gly Phe Ala Gly Leu Pro Asn Gly Lys Glu Glu 
            20                  25                  30          


Glu Gly Leu Gly Ser Ile Pro Glu Asn Phe Phe Gly Val Lys Leu 
        35                  40                  45          


<210> 28
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Ile 
1               5                   10                  15      


Pro Glu Asn Phe Phe Gly Val Thr Ser Glu Asp Leu Val Val Gln Glu 
            20                  25                  30          


Ala Ile Pro Met Ser Ile Pro Lys Leu 
        35                  40      


<210> 29
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Glu 
1               5                   10                  15      


Ala Ile Pro Met Ser Ile Pro Thr Ser Glu Asp Leu Val Val Gln Ile 
            20                  25                  30          


Pro Glu Asn Phe Phe Gly Val Lys Leu 
        35                  40      


<210> 30
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Leu Glu Pro Ala Gly Ala Ala Arg Gly Glu Ser Glu Ser Glu Gly Gly 
1               5                   10                  15      


Phe Phe Gly Phe Pro Ile Gly Glu Arg Glu Ser Thr Gly Gly Asp Arg 
            20                  25                  30          


Gly Leu Pro Ile Gly Glu Asn Glu Ala Gly Gly Lys Leu 
        35                  40                  45  


<210> 31
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Leu Glu Thr Glu Gly Arg Gly Glu Arg Glu Ala Gln Gly Glu Phe Pro 
1               5                   10                  15      


Glu Val Glu Gly Glu Glu Glu Gly Gly Gly Pro Glu Lys Glu Thr Gly 
            20                  25                  30          


Gly Glu Arg Glu Ala Gln Gly Lys Leu 
        35                  40      


<210> 32
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Leu Glu Ala Arg Gly Leu Glu Gly Gly Gly Gly Gly Ser Leu Leu Gly 
1               5                   10                  15      


Gly Tyr Pro Gly Ser Ser Arg Gly Gly Phe Lys Glu Gly Val Glu Gly 
            20                  25                  30          


Gly Pro Ala Gly Ala Ala Arg Gly Lys Leu 
        35                  40          


<210> 33
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Leu Glu Pro Gly Leu Ala Pro Gly Gly Glu Glu Gly Val Glu Glu Gly 
1               5                   10                  15      


Gly Pro Glu Glu Gly Val Glu Glu Gly Gly Phe Lys Glu Gly Val Glu 
            20                  25                  30          


Gly Glu Pro Glu Ser Ser Gly Lys Leu 
        35                  40      


<210> 34
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Leu Glu Glu Gly Glu Ala Arg Gly Ser Thr Ala Gln Glu Ala Gly Glu 
1               5                   10                  15      


Gly Pro Lys Glu Glu Glu Gly Leu Gly Ser Ser Glu Leu Glu Gly Arg 
            20                  25                  30          


Gly Ser Pro Val Ser Gln Glu Leu Gly Gln Arg Lys Leu 
        35                  40                  45  


<210> 35
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Leu Glu Ala Gln Glu Ala Gly Glu Gly Lys Glu Glu Glu Gly Leu Gly 
1               5                   10                  15      


Ser Pro Val Ser Gln Glu Leu Gly Gln Arg Ser Glu Leu Glu Gly Arg 
            20                  25                  30          


Gly Ser Pro Thr Glu Gly Glu Ala Arg Gly Ser Lys Leu 
        35                  40                  45  


<210> 36
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Leu Glu Glu Glu Glu Gly Leu Gly Ser Lys Glu Glu Glu Gly Leu Gly 
1               5                   10                  15      


Ser Pro Lys Glu Glu Glu Gly Leu Gly Ser Lys Glu Glu Glu Gly Leu 
            20                  25                  30          


Gly Ser Pro Lys Glu Glu Glu Gly Leu Gly Ser Lys Leu 
        35                  40                  45  


<210> 37
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Leu Glu Glu Leu Glu Gly Arg Gly Ser Lys Glu Glu Glu Gly Leu Gly 
1               5                   10                  15      


Ser Ile Pro Glu Asn Phe Phe Gly Val Phe Tyr Glu Ser Asp Val Met 
            20                  25                  30          


Gly Arg Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 38
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Leu Glu Glu Asn Phe Phe Gly Val Thr Glu Gly Glu Ala Arg Gly Ser 
1               5                   10                  15      


Pro Thr Ser Glu Asp Leu Val Val Gln Lys Glu Glu Glu Gly Leu Gly 
            20                  25                  30          


Ser Glu Ala Ile Pro Met Ser Ile Pro Lys Leu 
        35                  40              


<210> 39
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Leu Glu Ile Pro Met Ser Ile Pro Lys Glu Glu Glu Gly Leu Gly Ser 
1               5                   10                  15      


Ile Pro Glu Asn Phe Phe Gly Val Thr Glu Gly Glu Ala Arg Gly Ser 
            20                  25                  30          


Pro Thr Ser Glu Asp Leu Val Val Gln Lys Leu 
        35                  40              


<210> 40
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Leu Glu Leu Gln Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val 
1               5                   10                  15      


Gly Glu Ala Ile Pro Met Ser Ile Pro Ile Pro Glu Asn Phe Phe Gly 
            20                  25                  30          


Val Lys Glu Glu Glu Gly Leu Gly Ser Lys Leu 
        35                  40              


<210> 41
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Leu Glu Glu Glu Gly Val Glu Glu Gly Lys Glu Glu Glu Gly Leu Gly 
1               5                   10                  15      


Ser Gly Pro Ala Gly Ala Ala Arg Gly Ser Glu Leu Glu Gly Arg Gly 
            20                  25                  30          


Ser Pro Thr Glu Gly Glu Ala Arg Gly Ser Lys Leu 
        35                  40                  


<210> 42
<211> 46
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Leu Glu Pro Glu Ser Ser Gly Glu Ala Ile Pro Met Ser Ile Pro Thr 
1               5                   10                  15      


Ser Glu Asp Leu Val Val Gln Ile Pro Glu Asn Phe Phe Gly Val Glu 
            20                  25                  30          


Ala Glu Gly Thr Gly Gly Glu Arg Gly Val Leu Gly Lys Leu 
        35                  40                  45      


<210> 43
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Leu Glu Gly Gly Gly Ser Leu Leu Gly Glu Pro Glu Pro Glu Gly Glu 
1               5                   10                  15      


Arg Glu Ala Gln Gly Gly Val Glu Gly Val Glu Leu Gly Gly Phe Lys 
            20                  25                  30          


Glu Gly Val Glu Gly Glu Gln Glu Gly Arg Gly Lys Leu 
        35                  40                  45  


<210> 44
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Leu Glu Ser Gln Glu Leu Gly Gln Arg Glu Ser Glu Ser Glu Gly Ser 
1               5                   10                  15      


Glu Leu Glu Gly Arg Gly Ser Gly Phe Lys Glu Gly Val Glu Gly Lys 
            20                  25                  30          


Glu Glu Glu Gly Leu Gly Ser Gly Phe Phe Gly Phe Pro Ile Gly Lys 
        35                  40                  45              


Leu 
    


<210> 45
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Leu Glu Gln Tyr Glu Met His Gly Pro Lys Glu Glu Glu Gly Leu Gly 
1               5                   10                  15      


Ser Ser Glu Leu Glu Gly Arg Gly Ser Glu Ala Ile Pro Met Ser Ile 
            20                  25                  30          


Pro Thr Ile Pro Glu Asn Phe Phe Gly Val Val Glu Glu Pro His Thr 
        35                  40                  45              


Lys Leu 
    50  


<210> 46
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Leu Glu Gln Tyr Glu Met His Gly Pro Ser Glu Leu Glu Gly Arg Gly 
1               5                   10                  15      


Ser Ile Pro Glu Asn Phe Phe Gly Val Glu Ala Ile Pro Met Ser Ile 
            20                  25                  30          


Pro Thr Ser Glu Asp Leu Val Val Gln Ile Val Glu Glu Pro His Thr 
        35                  40                  45              


Lys Leu 
    50  


<210> 47
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Glu Gly Glu Gly Glu 
1               5                   10                  15      


Gly Ile Pro Glu Asn Phe Phe Gly Val Ser Glu Asp Leu Val Val Gln 
            20                  25                  30          


Ile Ser Glu Leu Glu Gly Arg Gly Ser Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 48

<400> 48
000


<210> 49

<400> 49
000


<210> 50
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Leu Glu Gln Tyr Glu Met His Gly Pro Ile Pro Glu Asn Phe Phe Gly 
1               5                   10                  15      


Val Ser Glu Leu Glu Gly Arg Gly Ser Glu Ala Ile Pro Met Ser Ile 
            20                  25                  30          


Pro Thr Glu Gly Glu Gly Glu Gly Glu Gly Val Glu Glu Pro His Thr 
        35                  40                  45              


Lys Leu 
    50  


<210> 51
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Leu Glu Gln Tyr Glu Met His Gly Pro Ser Glu Leu Glu Gly Arg Gly 
1               5                   10                  15      


Ser Glu Ala Ile Pro Met Ser Ile Pro Thr Lys Glu Glu Glu Gly Leu 
            20                  25                  30          


Gly Ser Ile Pro Glu Asn Phe Phe Gly Val Val Glu Glu Pro His Thr 
        35                  40                  45              


Lys Leu 
    50  


<210> 52
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Ala Ile Pro Met Ser Ile 
1               5                   10                  15      


Pro Thr Glu Gly Glu Gly Glu Gly Glu Gly Ile Pro Glu Asn Phe Phe 
            20                  25                  30          


Gly Val Ser Glu Asp Leu Val Val Gln Ile Val Glu Glu Pro His Thr 
        35                  40                  45              


Lys Leu 
    50  


<210> 53
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Leu Glu Gln Tyr Glu Met His Gly Pro Ser Glu Asp Leu Val Val Gln 
1               5                   10                  15      


Ile Glu Gly Glu Gly Glu Gly Glu Gly Ile Pro Glu Asn Phe Phe Gly 
            20                  25                  30          


Val Glu Ala Ile Pro Met Ser Ile Pro Thr Val Glu Glu Pro His Thr 
        35                  40                  45              


Lys Leu 
    50  


<210> 54
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Glu Gly Glu Gly Glu 
1               5                   10                  15      


Gly Ile Ser Glu Asp Leu Val Val Gln Ile Pro Glu Asn Phe Phe Gly 
            20                  25                  30          


Val Lys Glu Glu Glu Gly Leu Gly Ser Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 55
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Glu Gly Glu Gly Glu 
1               5                   10                  15      


Gly Ile Pro Glu Asn Phe Phe Gly Val Ser Glu Leu Glu Gly Arg Gly 
            20                  25                  30          


Ser Ser Glu Asp Leu Val Val Gln Ile Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 56
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Leu Glu Gln Tyr Glu Met His Gly Pro Ile Pro Glu Asn Phe Phe Gly 
1               5                   10                  15      


Val Glu Gly Glu Gly Glu Gly Glu Ser Glu Leu Glu Gly Arg Gly Ser 
            20                  25                  30          


Ser Glu Asp Leu Val Val Gln Ile Val Glu Glu Pro His Thr Lys Leu 
        35                  40                  45              


<210> 57
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Leu Glu Gln Tyr Glu Met His Gly Pro Ser Glu Leu Glu Gly Arg Gly 
1               5                   10                  15      


Ser Ile Pro Glu Asn Phe Phe Gly Val Lys Glu Glu Glu Gly Leu Gly 
            20                  25                  30          


Ser Ser Glu Asp Leu Val Val Gln Ile Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 58
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 58
Leu Glu Gln Tyr Glu Met His Gly Pro Ile Pro Glu Asn Phe Phe Gly 
1               5                   10                  15      


Val Ser Glu Leu Glu Gly Arg Gly Ser Ser Glu Asp Leu Val Val Gln 
            20                  25                  30          


Ile Lys Glu Glu Glu Gly Leu Gly Ser Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 59
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 59
Leu Glu Gln Tyr Glu Met His Gly Pro Lys Glu Glu Glu Gly Leu Gly 
1               5                   10                  15      


Ser Ile Pro Glu Asn Phe Phe Gly Val Ser Glu Leu Glu Gly Arg Gly 
            20                  25                  30          


Ser Glu Gly Glu Gly Glu Gly Glu Gly Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 60
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Leu Glu Gln Tyr Glu Met His Gly Pro Ser Glu Asp Leu Val Val Gln 
1               5                   10                  15      


Ile Lys Glu Glu Glu Gly Leu Gly Ser Ile Pro Glu Asn Phe Phe Gly 
            20                  25                  30          


Val Ser Glu Leu Glu Gly Arg Gly Ser Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 61
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 61
Leu Glu Gln Tyr Glu Met His Gly Pro Ser Glu Asp Leu Val Val Gln 
1               5                   10                  15      


Ile Glu Gly Glu Gly Glu Gly Glu Gly Ile Pro Glu Asn Phe Phe Gly 
            20                  25                  30          


Val Lys Glu Glu Glu Gly Leu Gly Ser Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 62
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 62
Leu Glu Gln Tyr Glu Met His Gly Pro Ser Glu Asp Leu Val Val Gln 
1               5                   10                  15      


Ile Glu Gly Glu Gly Glu Gly Glu Gly Ile Pro Glu Asn Phe Phe Gly 
            20                  25                  30          


Val Glu Ala Ile Pro Met Ser Ile Pro Thr Glu Pro His Thr Lys Leu 
        35                  40                  45              


<210> 63
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 63
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Glu Gly Glu Gly Glu 
1               5                   10                  15      


Gly Ile Pro Glu Asn Phe Phe Gly Val Glu Ala Ile Pro Met Ser Ile 
            20                  25                  30          


Pro Thr Ser Glu Leu Glu Gly Arg Gly Ser Glu Pro His Thr Lys Leu 
        35                  40                  45              


<210> 64
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Ala Ile Pro Met Ser Ile 
1               5                   10                  15      


Pro Thr Ser Glu Leu Glu Gly Arg Gly Ser Ile Pro Glu Asn Phe Phe 
            20                  25                  30          


Gly Val Glu Gly Glu Gly Glu Gly Glu Gly Glu Pro His Thr Lys Leu 
        35                  40                  45              


<210> 65
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Leu Glu Gln Tyr Glu Met His Gly Pro Ser Glu Leu Glu Gly Arg Gly 
1               5                   10                  15      


Ser Ile Pro Glu Asn Phe Phe Gly Val Glu Gly Glu Gly Glu Gly Glu 
            20                  25                  30          


Gly Lys Glu Glu Glu Gly Leu Gly Ser Val Glu Glu Pro His Thr Lys 
        35                  40                  45              


Leu 
    


<210> 66
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Leu Glu Gln Tyr Glu Met His Gly Pro Ile Pro Glu Asn Phe Phe Gly 
1               5                   10                  15      


Val Ser Glu Asp Leu Val Val Gln Ile Glu Gly Glu Gly Glu Gly Glu 
            20                  25                  30          


Gly Glu Ala Ile Pro Met Ser Ile Pro Thr Glu Pro His Thr Lys Leu 
        35                  40                  45              


<210> 67
<211> 10
<212> PRT
<213> Homo sapiens

<400> 67
Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser 
1               5                   10  


<210> 68
<211> 11
<212> PRT
<213> Homo sapiens

<400> 68
Thr Ala Ser Glu Leu Glu Gly Arg Gly Thr Ile 
1               5                   10      


<210> 69
<211> 11
<212> PRT
<213> Homo sapiens

<400> 69
Thr Phe Lys Glu Glu Glu Gly Leu Gly Ser Val 
1               5                   10      


<210> 70
<211> 9
<212> PRT
<213> Homo sapiens

<400> 70
Val Asp Ile Pro Glu Asn Phe Phe Gly 
1               5                   


<210> 71
<211> 5
<212> PRT
<213> Homo sapiens

<400> 71
Ala Arg Gly Ser Val 
1               5   


<210> 72
<211> 10
<212> PRT
<213> Homo sapiens

<400> 72
Ile Leu Thr Val Lys Pro Ile Phe Glu Val 
1               5                   10  


<210> 73
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ser His His His His His 
1               5                   10                  15      


His 
    


<210> 74
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 74
His His His His His His 
1               5       


<210> 75
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Glu 
1               5                   10                  15      


Gly Glu Gly Glu Gly Glu Gly Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu 
        35                  40                  45          


<210> 76
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Leu Glu Gln Tyr Glu Met His Gly Pro Glu Gly Leu Arg Val Gly Ser 
1               5                   10                  15      


Glu Leu Glu Gly Arg Gly Ser Phe Tyr Glu Ser Asp Val Met Gly Arg 
            20                  25                  30          


Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr Lys Leu 
        35                  40                  45          


