                         SEQUENCE LISTING

<110>  Massachusetts Eye and Ear Infirmary
 
<120>  Methods for Treating Corneal and Conjunctival Inflammation and 
       Inflammatory Disorders

<130>  00633-0129WO1

<150>  61/601,300
<151>  2012-02-21

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val 
1               5                   10                  15      


Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala 
            20                  25                  30          


Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser 
        35                  40                  45              


Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg 
    50                  55                  60                  


Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr Ala Phe 
                85                  90                  95      


Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly Asp Pro 
            100                 105                 110         


Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro Asn Ala 
        115                 120                 125             


Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly Ala Gln 
    130                 135                 140                 


Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln Gly Asp 
145                 150                 155                 160 


Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro Pro Leu 
                165                 170                 175     


Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met Arg Leu 
            180                 185                 190         


Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Ala Ser Lys Pro 
        195                 200                 205             


Ala Gly Asp Gln Leu Pro Ala Ala Leu Trp Thr Ser Ser Ala Val Leu 
    210                 215                 220                 


Gly Leu Leu Leu Leu Ala Leu Pro Thr Tyr His Leu Trp Lys Arg Cys 
225                 230                 235                 240 


Arg His Leu Ala Glu Asp Asp Thr His Pro Pro Ala Ser Leu Arg Leu 
                245                 250                 255     


Leu Pro Gln Val Ser Ala Trp Ala Gly Leu Arg Gly Thr Gly Gln Val 
            260                 265                 270         


Gly Ile Ser Pro Ser 
        275         


<210>  2
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val 
1               5                   10                  15      


Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala 
            20                  25                  30          


Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser 
        35                  40                  45              


Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg 
    50                  55                  60                  


Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr Ala Phe 
                85                  90                  95      


Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly Asp Pro 
            100                 105                 110         


Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro Asn Ala 
        115                 120                 125             


Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly Ala Gln 
    130                 135                 140                 


Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln Gly Asp 
145                 150                 155                 160 


Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro Pro Leu 
                165                 170                 175     


Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met Arg Leu 
            180                 185                 190         


Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu His Ser 
        195                 200                 205             


Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp 
    210                 215                 220                 


Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln Glu Pro Pro Asp 
225                 230                 235                 240 


Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro Ala Pro 
                245                 250                 255     


Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr Arg Thr 
            260                 265                 270         


Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu Val Ile 
        275                 280                 285             


Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala Ala Leu 
    290                 295                 300                 


Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu Pro Thr 
305                 310                 315                 320 


Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp Thr His 
                325                 330                 335     


Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp Ala Gly 
            340                 345                 350         


Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
        355                 360                 


<210>  3
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val 
1               5                   10                  15      


Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala 
            20                  25                  30          


Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser 
        35                  40                  45              


Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg 
    50                  55                  60                  


Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr Ala Phe 
                85                  90                  95      


Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly Asp Pro 
            100                 105                 110         


Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro Asn Ala 
        115                 120                 125             


Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly Ala Gln 
    130                 135                 140                 


Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln Gly Asp 
145                 150                 155                 160 


Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro Pro Leu 
                165                 170                 175     


Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met Arg Leu 
            180                 185                 190         


Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu His Ser 
        195                 200                 205             


Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp 
    210                 215                 220                 


Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln Glu Pro Pro Asp 
225                 230                 235                 240 


Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro Ala Pro 
                245                 250                 255     


Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr Arg Thr 
            260                 265                 270         


Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu Val Ile 
        275                 280                 285             


Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala Ala Leu 
    290                 295                 300                 


Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu Pro Thr 
305                 310                 315                 320 


Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp Thr His 
                325                 330                 335     


Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp Ala Gly 
            340                 345                 350         


Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
        355                 360                 


<210>  4
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val 
1               5                   10                  15      


Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala 
            20                  25                  30          


Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser 
        35                  40                  45              


Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg 
    50                  55                  60                  


Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr Ala Phe 
                85                  90                  95      


Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly Asp Pro 
            100                 105                 110         


Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro Asn Ala 
        115                 120                 125             


Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly Ala Gln 
    130                 135                 140                 


Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln Gly Asp 
145                 150                 155                 160 


Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro Pro Leu 
                165                 170                 175     


Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met Arg Leu 
            180                 185                 190         


Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu His Ser 
        195                 200                 205             


Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Pro Pro Asn 
    210                 215                 220                 


Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp 
225                 230                 235                 240 


Thr Thr Ser Gln Glu Pro Pro Asp Thr Thr Ser Gln Glu Pro Pro Asp 
                245                 250                 255     


Thr Thr Ser Gln Glu Pro Pro Asp Thr Thr Ser Pro Glu Pro Pro Asp 
            260                 265                 270         


Lys Thr Ser Pro Glu Pro Ala Pro Gln Gln Gly Ser Thr His Thr Pro 
        275                 280                 285             


Arg Ser Pro Gly Ser Thr Arg Thr Arg Arg Pro Glu Ile Ser Gln Ala 
    290                 295                 300                 


Gly Pro Thr Gln Gly Glu Val Ile Pro Thr Gly Ser Ser Lys Pro Ala 
305                 310                 315                 320 


Gly Asp Gln Leu Pro Ala Ala Leu Trp Thr Ser Ser Ala Val Leu Gly 
                325                 330                 335     


Leu Leu Leu Leu Ala Leu Pro Thr Tyr His Leu Trp Lys Arg Cys Arg 
            340                 345                 350         


His Leu Ala Glu Asp Asp Thr His Pro Pro Ala Ser Leu Arg Leu Leu 
        355                 360                 365             


Pro Gln Val Ser Ala Trp Ala Gly Leu Arg Gly Thr Gly Gln Val Gly 
    370                 375                 380                 


Ile Ser Pro Ser 
385             


<210>  5
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val 
1               5                   10                  15      


Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala 
            20                  25                  30          


Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser 
        35                  40                  45              


Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg 
    50                  55                  60                  


Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr Ala Phe 
                85                  90                  95      


Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly Asp Pro 
            100                 105                 110         


Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro Asn Ala 
        115                 120                 125             


Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly Ala Gln 
    130                 135                 140                 


Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln Gly Asp 
145                 150                 155                 160 


Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro Pro Leu 
                165                 170                 175     


Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met Arg Leu 
            180                 185                 190         


Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu His Ser 
        195                 200                 205             


Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Pro Pro Asn 
    210                 215                 220                 


Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp 
225                 230                 235                 240 


Thr Thr Ser Gln Glu Pro Pro Asp Thr Thr Ser Gln Glu Pro Pro Asp 
                245                 250                 255     


Thr Thr Ser Gln Glu Pro Pro Asp Thr Thr Ser Pro Glu Pro Pro Asp 
            260                 265                 270         


Lys Thr Ser Pro Glu Pro Ala Pro Gln Gln Gly Ser Thr His Thr Pro 
        275                 280                 285             


Arg Ser Pro Gly Ser Thr Arg Thr Arg Arg Pro Glu Ile Ser Gln Ala 
    290                 295                 300                 


Gly Pro Thr Gln Gly Glu Val Ile Pro Thr Gly Ser Ser Lys Pro Ala 
305                 310                 315                 320 


Gly Asp Gln Leu Pro Ala Ala Leu Trp Thr Ser Ser Ala Val Leu Gly 
                325                 330                 335     


Leu Leu Leu Leu Ala Leu Pro Thr Tyr His Leu Trp Lys Arg Cys Arg 
            340                 345                 350         


His Leu Ala Glu Asp Asp Thr His Pro Pro Ala Ser Leu Arg Leu Leu 
        355                 360                 365             


Pro Gln Val Ser Ala Trp Ala Gly Leu Arg Gly Thr Gly Gln Val Gly 
    370                 375                 380                 


Ile Ser Pro Ser 
385             


<210>  6
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val 
1               5                   10                  15      


Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala 
            20                  25                  30          


Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser 
        35                  40                  45              


Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg 
    50                  55                  60                  


Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr Ala Phe 
                85                  90                  95      


Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly Asp Pro 
            100                 105                 110         


Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro Asn Ala 
        115                 120                 125             


Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly Ala Gln 
    130                 135                 140                 


Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln Gly Asp 
145                 150                 155                 160 


Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro Pro Leu 
                165                 170                 175     


Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met Arg Leu 
            180                 185                 190         


Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu His Ser 
        195                 200                 205             


Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp 
    210                 215                 220                 


Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Pro Glu Pro Pro Asp 
225                 230                 235                 240 


Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro Ala Pro 
                245                 250                 255     


Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr Arg Thr 
            260                 265                 270         


Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu Val Ile 
        275                 280                 285             


Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala Ala Leu 
    290                 295                 300                 


Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu Pro Thr 
305                 310                 315                 320 


Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp Thr His 
                325                 330                 335     


Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp Ala Gly 
            340                 345                 350         


Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
        355                 360                 


<210>  7
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val 
1               5                   10                  15      


Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala 
            20                  25                  30          


Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser 
        35                  40                  45              


Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg 
    50                  55                  60                  


Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr Ala Phe 
                85                  90                  95      


Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly Asp Pro 
            100                 105                 110         


Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro Asn Ala 
        115                 120                 125             


Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly Ala Gln 
    130                 135                 140                 


Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln Gly Asp 
145                 150                 155                 160 


Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro Pro Leu 
                165                 170                 175     


Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met Arg Leu 
            180                 185                 190         


Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu His Ser 
        195                 200                 205             


Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp 
    210                 215                 220                 


Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln Glu Pro Pro Asp 
225                 230                 235                 240 


Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro Ala Pro 
                245                 250                 255     


Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr Arg Thr 
            260                 265                 270         


Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu Val Ile 
        275                 280                 285             


Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala Ala Leu 
    290                 295                 300                 


Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu Pro Thr 
305                 310                 315                 320 


Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp Thr His 
                325                 330                 335     


Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp Ala Gly 
            340                 345                 350         


Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
        355                 360                 


<210>  8
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  8

Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His Asn 
1               5                   10                  15      


Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn Arg 
            20                  25                  30          


Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala Ser 
        35                  40                  45              


Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn Pro 
    50                  55                  60                  


Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu Pro 
65                  70                  75                  80  


Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly Val 
                85                  90                  95      


Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys Gly 
            100                 105                 110         


His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu Pro 
        115                 120                 125             


Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu Ser 
    130                 135                 140                 


Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly Glu 
145                 150                 155                 160 


Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys Asp 
                165                 170                 175     


Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser Leu 
            180                 185                 190         


Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp Lys 
        195                 200                 205             


Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly Ala 
    210                 215                 220                 


Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala Pro 
225                 230                 235                 240 


Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu Lys 
                245                 250                 255     


Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser Tyr 
            260                 265                 270         


Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe Ser 
        275                 280                 285             


Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu Gly 
    290                 295                 300                 


Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn Ala 
305                 310                 315                 320 


Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe Gly 
                325                 330                 335     


Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu Asp 
            340                 345                 350         


Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile Tyr 
        355                 360                 365             


Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln Arg 
    370                 375                 380                 


Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln Ser 
385                 390                 395                 400 


Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val Ala 
                405                 410                 415     


Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg Pro 
            420                 425                 430         


Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn Arg 
        435                 440                 445             


Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile Asp 
    450                 455                 460                 


Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr Ile 
465                 470                 475                 480 


Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu Ser 
                485                 490                 495     


Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile Thr 
            500                 505                 510         


Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His Gln 
        515                 520                 525             


Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln Ile 
    530                 535                 540                 


Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser Thr 
545                 550                 555                 560 


Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu Lys 
                565                 570                 575     


Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His Glu 
            580                 585                 590         


Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu Lys 
        595                 600                 605             


Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr Leu 
    610                 615                 620                 


Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu Thr 
625                 630                 635                 640 


Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile Leu 
                645                 650                 655     


Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser Gly 
            660                 665                 670         


Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His Leu 
        675                 680                 685             


Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser Arg 
    690                 695                 700                 


Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn Glu 
705                 710                 715                 720 


Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile Pro 
                725                 730                 735     


Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro Thr 
            740                 745                 750         


Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys Met 
        755                 760                 765             


Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn Ser 
    770                 775                 780                 


Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe Ser 
785                 790                 795                 800 


Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr Thr 
                805                 810                 815     


Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu Gln 
            820                 825                 830         


Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu Ser 
        835                 840                 845             


Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His Cys 
    850                 855                 860                 


Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu Ala 
865                 870                 875                 880 


Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met Asp 
                885                 890                 895     


Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro Glu 
            900                 905                 910         


Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala His 
        915                 920                 925             


Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe Thr 
    930                 935                 940                 


Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu Leu 
945                 950                 955                 960 


Leu Ile Ser Tyr Val Met Trp Lys Ala Gly Phe Phe Lys Arg Gln Tyr 
                965                 970                 975     


Lys Ser Ile Leu Gln Glu Glu Asn Arg Arg Asp Ser Trp Ser Tyr Ile 
            980                 985                 990         


Asn Ser Lys Ser Asn Asp Asp 
        995                 


<210>  9
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr Glu Trp Arg 
1               5                   10                  15      


Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala Pro Ser Cys 
            20                  25                  30          


Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys Lys Gln Leu 
        35                  40                  45              


Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys Ala Arg Arg 
    50                  55                  60                  


Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu Glu Glu Pro 
65                  70                  75                  80  


Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser Gln Gly Ala 
                85                  90                  95      


Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val Arg Val Thr 
            100                 105                 110         


Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe Leu Arg Ala 
        115                 120                 125             


Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser 
    130                 135                 140                 


Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His Ala Leu Leu 
145                 150                 155                 160 


Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser 
                165                 170                 175     


Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val Pro Ser Lys 
            180                 185                 190         


Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln Ser Pro Phe 
        195                 200                 205             


Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln Ala Phe Glu 
    210                 215                 220                 


Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp Ser Pro Glu 
225                 230                 235                 240 


Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln Glu Gln Ile 
                245                 250                 255     


Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser Asp Asp Thr 
            260                 265                 270         


Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe Met Pro Ser 
        275                 280                 285             


Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser Arg Ser Thr 
    290                 295                 300                 


Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala Leu Ser Ala 
305                 310                 315                 320 


Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro Val 
                325                 330                 335     


Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu Leu 
            340                 345                 350         


Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp Ala Tyr Asn 
        355                 360                 365             


Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu Pro Pro Gly 
    370                 375                 380                 


Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu Lys Arg Glu 
385                 390                 395                 400 


Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg Ile Asn Gln 
                405                 410                 415     


Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys Leu Pro Glu 
            420                 425                 430         


Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu Glu Leu Ile 
        435                 440                 445             


Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp Thr Gln Pro 
    450                 455                 460                 


Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln Cys Gly Val 
465                 470                 475                 480 


Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu Cys Ser Val 
                485                 490                 495     


Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg Ala Pro Asn 
            500                 505                 510         


Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln Cys Gly Arg 
        515                 520                 525             


Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu Cys Asp Asp 
    530                 535                 540                 


Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly Phe Gly Arg 
545                 550                 555                 560 


Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr Gly Arg Ala 
                565                 570                 575     


Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro Glu Gly Gly 
            580                 585                 590         


Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys Gln Cys Leu 
        595                 600                 605             


Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly Cys Lys Thr 
    610                 615                 620                 


Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala Phe Arg Thr 
625                 630                 635                 640 


Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His Thr Asn Val 
                645                 650                 655     


Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys Lys Glu Arg 
            660                 665                 670         


Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp Asp Ala Arg 
        675                 680                 685             


Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly Ala Asp His 
    690                 695                 700                 


Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val Ala Val Gly 
705                 710                 715                 720 


Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile Tyr Asp Arg 
                725                 730                 735     


Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu Asn Trp Lys 
            740                 745                 750         


Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr Thr Ile Asn 
        755                 760                 765             


Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
    770                 775                 


<210>  10
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Cys Arg Arg Thr Arg Glu Gly Pro Ser Lys Ala Met Ile Phe 
1               5                   10                  15      


Pro Trp Lys Cys Gln Ser Thr Gln Arg Asp Leu Trp Asn Ile Phe Lys 
            20                  25                  30          


Leu Trp Gly Trp Thr Met Leu Cys Cys Asp Phe Leu Ala His His Gly 
        35                  40                  45              


Thr Asp Cys Trp Thr Tyr His Tyr Ser Glu Lys Pro Met Asn Trp Gln 
    50                  55                  60                  


Arg Ala Arg Arg Phe Cys Arg Asp Asn Tyr Thr Asp Leu Val Ala Ile 
65                  70                  75                  80  


Gln Asn Lys Ala Glu Ile Glu Tyr Leu Glu Lys Thr Leu Pro Phe Ser 
                85                  90                  95      


Arg Ser Tyr Tyr Trp Ile Gly Ile Arg Lys Ile Gly Gly Ile Trp Thr 
            100                 105                 110         


Trp Val Gly Thr Asn Lys Ser Leu Thr Glu Glu Ala Glu Asn Trp Gly 
        115                 120                 125             


Asp Gly Glu Pro Asn Asn Lys Lys Asn Lys Glu Asp Cys Val Glu Ile 
    130                 135                 140                 


Tyr Ile Lys Arg Asn Lys Asp Ala Gly Lys Trp Asn Asp Asp Ala Cys 
145                 150                 155                 160 


His Lys Leu Lys Ala Ala Leu Cys Tyr Thr Ala Ser Cys Gln Pro Trp 
                165                 170                 175     


Ser Cys Ser Gly His Gly Glu Cys Val Glu Ile Ile Asn Asn Tyr Thr 
            180                 185                 190         


Cys Asn Cys Asp Val Gly Tyr Tyr Gly Pro Gln Cys Gln Phe Val Ile 
        195                 200                 205             


Gln Cys Glu Pro Leu Glu Ala Pro Glu Leu Gly Thr Met Asp Cys Thr 
    210                 215                 220                 


His Pro Leu Gly Asn Phe Ser Phe Ser Ser Gln Cys Ala Phe Ser Cys 
225                 230                 235                 240 


Ser Glu Gly Thr Asn Leu Thr Gly Ile Glu Glu Thr Thr Cys Gly Pro 
                245                 250                 255     


Phe Gly Asn Trp Ser Ser Pro Glu Pro Thr Cys Gln Val Ile Gln Cys 
            260                 265                 270         


Glu Pro Leu Ser Ala Pro Asp Leu Gly Ile Met Asn Cys Ser His Pro 
        275                 280                 285             


Leu Ala Ser Phe Ser Phe Thr Ser Ala Cys Thr Phe Ile Cys Ser Glu 
    290                 295                 300                 


Gly Thr Glu Leu Ile Gly Lys Lys Lys Thr Ile Cys Glu Ser Ser Gly 
305                 310                 315                 320 


Ile Trp Ser Asn Pro Ser Pro Ile Cys Gln Lys Leu Asp Lys Ser Phe 
                325                 330                 335     


Ser Met Ile Lys Glu Gly Asp Tyr Asn Pro Leu Phe Ile Pro Val Ala 
            340                 345                 350         


Val Met Val Thr Ala Phe Ser Gly Leu Ala Phe Ile Ile Trp Leu Ala 
        355                 360                 365             


Arg Arg Leu Lys Lys Gly Lys Lys Ser Lys Arg Ser Met Asn Asp Pro 
    370                 375                 380                 


Tyr 
385 


<210>  11
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Phe Gly Leu Ala Leu Leu Leu Ala Gly Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu 
            20                  25                  30          


Pro Val Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp 
    50                  55                  60                  


Thr Ser Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr 
65                  70                  75                  80  


Val Arg Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly 
                85                  90                  95      


Ser Cys Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr 
            100                 105                 110         


Ala Phe Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly 
        115                 120                 125             


Asp Pro Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro 
    130                 135                 140                 


Asn Ala Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly 
145                 150                 155                 160 


Ala Gln Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln 
                165                 170                 175     


Gly Asp Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro 
            180                 185                 190         


Pro Leu Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met 
        195                 200                 205             


Arg Leu Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu 
    210                 215                 220                 


His Ser Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser 
225                 230                 235                 240 


Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln Glu Pro 
                245                 250                 255     


Pro Asp Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro 
            260                 265                 270         


Ala Pro Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr 
        275                 280                 285             


Arg Thr Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu 
    290                 295                 300                 


Val Ile Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala 
305                 310                 315                 320 


Ala Leu Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu 
                325                 330                 335     


Pro Thr Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp 
            340                 345                 350         


Thr His Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp 
        355                 360                 365             


Ala Gly Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
    370                 375                 380         


<210>  12
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      


Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          


Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              


Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  


Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  


Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      


Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         


Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             


Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 


Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 


Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     


Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         


Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             


Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 


Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 


Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     


Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         


Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             


Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 


Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 


Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     


Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         


Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             


Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 


Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 


Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     


Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         


Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             


Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 


Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 


Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     


Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         


Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             


Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 


Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 


Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     


Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         


Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             


Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 


Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 


Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     


Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         


Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             


Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 


Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 


Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     


Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         


Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             


Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 


Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 


Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     


Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         


Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             


Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 


Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 


Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     


Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         


Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             


Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 


Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 


His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     


Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         


Leu Leu Ile Ser Tyr Val Met Trp  Lys Ala Gly Phe Phe  Lys Arg Gln 
        995                 1000                 1005             


Tyr Lys  Ser Ile Leu Gln Glu  Glu Asn Arg Arg Asp  Ser Trp Ser 
    1010                 1015                 1020             


Tyr Ile  Asn Ser Lys Ser Asn  Asp Asp 
    1025                 1030         


<210>  13
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      


Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          


Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              


Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  


Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  


Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      


Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         


Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             


Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 


Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 


Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     


Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         


Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             


Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 


Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 


Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     


Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         


Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             


Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 


Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 


Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     


Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         


Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             


Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 


Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 


Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     


Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         


Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys 
        435                 440                 445             


Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu 
    450                 455                 460                 


Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp 
465                 470                 475                 480 


Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln 
                485                 490                 495     


Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu 
            500                 505                 510         


Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg 
        515                 520                 525             


Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln 
    530                 535                 540                 


Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu 
545                 550                 555                 560 


Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly 
                565                 570                 575     


Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr 
            580                 585                 590         


Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro 
        595                 600                 605             


Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys 
    610                 615                 620                 


Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly 
625                 630                 635                 640 


Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala 
                645                 650                 655     


Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His 
            660                 665                 670         


Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys 
        675                 680                 685             


Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp 
    690                 695                 700                 


Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly 
705                 710                 715                 720 


Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val 
                725                 730                 735     


Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile 
            740                 745                 750         


Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu 
        755                 760                 765             


Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr 
    770                 775                 780                 


Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
785                 790                 795             


<210>  14
<211>  1546
<212>  DNA
<213>  Homo sapiens

<400>  14
gggactgagc atggatttcg gactggccct cctgctggcg gggcttctgg ggctcctcct       60

cggccagtcc ctccaggtga agcccctgca ggtggagccc ccggagccgg tggtggccgt      120

ggccttgggc gcctcgcgcc agctcacctg ccgcctggcc tgcgcggacc gcggggcctc      180

ggtgcagtgg cggggcctgg acaccagcct gggcgcggtg cagtcggaca cgggccgcag      240

cgtcctcacc gtgcgcaacg cctcgctgtc ggcggccggg acccgcgtgt gcgtgggctc      300

ctgcgggggc cgcaccttcc agcacaccgt gcagctcctt gtgtacgcct tcccggacca      360

gctgaccgtc tccccagcag ccctggtgcc tggtgacccg gaggtggcct gtacggccca      420

caaagtcacg cccgtggacc ccaacgcgct ctccttctcc ctgctcgtcg ggggccagga      480

actggagggg gcgcaagccc tgggcccgga ggtgcaggag gaggaggagg agccccaggg      540

ggacgaggac gtgctgttca gggtgacaga gcgctggcgg ctgccgcccc tggggacccc      600

tgtcccgccc gccctctact gccaggccac gatgaggctg cctggcttgg agctcagcca      660

ccgccaggcc atccccgtcc tgcacagccc gacctccccg gagcctcccg acaccacctc      720

cccggagtct cccgacacca cctccccgga gtctcccgac accacctccc aggagcctcc      780

cgacaccacc tccccggagc ctcccgacaa gacctccccg gagcccgccc cccagcaggg      840

ctccacacac acccccagga gcccaggctc caccaggact cgccgccctg agatctccca      900

ggctgggccc acgcagggag aagtgatccc aacaggctcg tccaaacctg cgggtgacca      960

gctgcccgcg gctctgtgga ccagcagtgc ggtgctggga ctgctgctcc tggccttgcc     1020

cacctatcac ctctggaaac gctgccggca cctggctgag gacgacaccc acccaccagc     1080

ttctctgagg cttctgcccc aggtgtcggc ctgggctggg ttaaggggga ccggccaggt     1140

cgggatcagc ccctcctgag tggccagcct ttccccctgt gaaagcaaaa tagcttggac     1200

cccttcaagt tgagaactgg tcagggcaaa cctgcctccc attctactca aagtcatccc     1260

tctgttcaca gagatggatg catgttctga ttgcctcttt ggagaagctc atcagaaact     1320

caaaagaagg ccactgtttg tctcacctac ccatgacctg aagcccctcc ctgagtggtc     1380

cccacctttc tggacggaac cacgtacttt ttacatacat tgattcatgt ctcacgtctc     1440

cctaaaaatg cgtaagacca agctgtgccc tgaccaccct gggcccctgt cgtcaggacc     1500

tcctgaggct ttggcaaata aacctcctaa aatgataaaa aaaaaa                    1546


<210>  15
<211>  2442
<212>  DNA
<213>  Homo sapiens

<400>  15
aggaggaagg ggagggaaaa ggggaggagg aggaggatgt gagactgggt tagagaaatg       60

aaagaaagca aggctttctg ttgacattca gtgcagtcta cctgcagcac agcacactcc      120

ctttgggcaa ggacctgaga cccttgtgct aagtcaagag gctcaatggg ctgcagaaga      180

actagagaag gaccaagcaa agccatgata tttccatgga aatgtcagag cacccagagg      240

gacttatgga acatcttcaa gttgtggggg tggacaatgc tctgttgtga tttcctggca      300

catcatggaa ccgactgctg gacttaccat tattctgaaa aacccatgaa ctggcaaagg      360

gctagaagat tctgccgaga caattacaca gatttagttg ccatacaaaa caaggcggaa      420

attgagtatc tggagaagac tctgcctttc agtcgttctt actactggat aggaatccgg      480

aagataggag gaatatggac gtgggtggga accaacaaat ctcttactga agaagcagag      540

aactggggag atggtgagcc caacaacaag aagaacaagg aggactgcgt ggagatctat      600

atcaagagaa acaaagatgc aggcaaatgg aacgatgacg cctgccacaa actaaaggca      660

gccctctgtt acacagcttc ttgccagccc tggtcatgca gtggccatgg agaatgtgta      720

gaaatcatca ataattacac ctgcaactgt gatgtggggt actatgggcc ccagtgtcag      780

tttgtgattc agtgtgagcc tttggaggcc ccagagctgg gtaccatgga ctgtactcac      840

cctttgggaa acttcagctt cagctcacag tgtgccttca gctgctctga aggaacaaac      900

ttaactggga ttgaagaaac cacctgtgga ccatttggaa actggtcatc tccagaacca      960

acctgtcaag tgattcagtg tgagcctcta tcagcaccag atttggggat catgaactgt     1020

agccatcccc tggccagctt cagctttacc tctgcatgta ccttcatctg ctcagaagga     1080

actgagttaa ttgggaagaa gaaaaccatt tgtgaatcat ctggaatctg gtcaaatcct     1140

agtccaatat gtcaaaaatt ggacaaaagt ttctcaatga ttaaggaggg tgattataac     1200

cccctcttca ttccagtggc agtcatggtt actgcattct ctgggttggc atttatcatt     1260

tggctggcaa ggagattaaa aaaaggcaag aaatccaaga gaagtatgaa tgacccatat     1320

taaatcgccc ttggtgaaag aaaattcttg gaatactaaa aatcatgaga tcctttaaat     1380

ccttccatga aacgttttgt gtggtggcac ctcctacgtc aaacatgaag tgtgtttcct     1440

tcagtgcatc tgggaagatt tctacctgac caacagttcc ttcagcttcc atttcgcccc     1500

tcatttatcc ctcaaccccc agcccacagg tgtttataca gctcagcttt ttgtcttttc     1560

tgaggagaaa caaataagac cataaaggga aaggattcat gtggaatata aagatggctg     1620

actttgctct ttcttgactc ttgttttcag tttcaattca gtgctgtact tgatgacaga     1680

cacttctaaa tgaagtgcaa atttgataca tatgtgaata tggactcagt tttcttgcag     1740

atcaaatttc acgtcgtctt ctgtatactg tggaggtaca ctcttataga aagttcaaaa     1800

agtctacgct ctcctttctt tctaactcca gtgaagtaat ggggtcctgc tcaagttgaa     1860

agagtcctat ttgcactgta gcctcgccgt ctgtgaattg gaccatccta tttaactggc     1920

ttcagcctcc ccaccttctt cagccacctc tctttttcag ttggctgact tccacaccta     1980

gcatctcatg agtgccaagc aaaaggagag aagagagaaa tagcctgcgc tgttttttag     2040

tttgggggtt ttgctgtttc cttttatgag acccattcct atttcttata gtcaatgttt     2100

cttttatcac gatattatta gtaagaaaac atcactgaaa tgctagctgc aagtgacatc     2160

tctttgatgt catatggaag agttaaaaca ggtggagaaa ttccttgatt cacaatgaaa     2220

tgctctcctt tcccctgccc ccagaccttt tatccactta cctagattct acatattctt     2280

taaatttcat ctcaggcctc cctcaacccc accacttctt ttataactag tcctttacta     2340

atccaaccca tgatgagctc ctcttcctgg cttcttactg aaaggttacc ctgtaacatg     2400

caattttgca tttgaataaa gcctgctttt taagtgttaa ct                        2442


<210>  16
<211>  2798
<212>  DNA
<213>  Homo sapiens

<400>  16
cgttgctgtc gctctgcacg cacctatgtg gaaactaaag cccagagaga aagtctgact       60

tgccccacag ccagtgagtg actgcagcag caccagaatc tggtctgttt cctgtttggc      120

tcttctacca ctacggcttg ggatctcggg catggtggct ttgccaatgg tccttgtttt      180

gctgctggtc ctgagcagag gtgagagtga attggacgcc aagatcccat ccacagggga      240

tgccacagaa tggcggaatc ctcacctgtc catgctgggg tcctgccagc cagccccctc      300

ctgccagaag tgcatcctct cacaccccag ctgtgcatgg tgcaagcaac tgaacttcac      360

cgcgtcggga gaggcggagg cgcggcgctg cgcccgacga gaggagctgc tggctcgagg      420

ctgcccgctg gaggagctgg aggagccccg cggccagcag gaggtgctgc aggaccagcc      480

gctcagccag ggcgcccgcg gagagggtgc cacccagctg gcgccgcagc gggtccgggt      540

cacgctgcgg cctggggagc cccagcagct ccaggtccgc ttccttcgtg ctgagggata      600

cccggtggac ctgtactacc ttatggacct gagctactcc atgaaggacg acctggaacg      660

cgtgcgccag ctcgggcacg ctctgctggt ccggctgcag gaagtcaccc attctgtgcg      720

cattggtttt ggttcctttg tggacaaaac ggtgctgccc tttgtgagca cagtaccctc      780

caaactgcgc cacccctgcc ccacccggct ggagcgctgc cagtcaccat tcagctttca      840

ccatgtgctg tccctgacgg gggacgcaca agccttcgag cgggaggtgg ggcgccagag      900

tgtgtccggc aatctggact cgcctgaagg tggcttcgat gccattctgc aggctgcact      960

ctgccaggag cagattggct ggagaaatgt gtcccggctg ctggtgttca cttcagacga     1020

cacattccat acagctgggg acgggaagtt gggcggcatt ttcatgccca gtgatgggca     1080

ctgccacttg gacagcaatg gcctctacag tcgcagcaca gagtttgact acccttctgt     1140

gggtcaggta gcccaggccc tctctgcagc aaatatccag cccatctttg ctgtcaccag     1200

tgccgcactg cctgtctacc aggagctgag taaactgatt cctaagtctg cagttgggga     1260

gctgagtgag gactccagca acgtggtaca gctcatcatg gatgcttata atagcctgtc     1320

ttccaccgtg acccttgaac actcttcact ccctcctggg gtccacattt cttacgaatc     1380

ccagtgtgag ggtcctgaga agagggaggg taaggctgag gatcgaggac agtgcaacca     1440

cgtccgaatc aaccagacgg tgactttctg ggtttctctc caagccaccc actgcctccc     1500

agagccccat ctcctgaggc tccgggccct tggcttctca gaggagctga ttgtggagtt     1560

gcacacgctg tgtgactgta attgcagtga cacccagccc caggctcccc actgcagtga     1620

tggccaggga cacctacaat gtggtgtatg cagctgtgcc cctggccgcc taggtcggct     1680

ctgtgagtgc tctgtggcag agctgtcctc cccagacctg gaatctgggt gccgggctcc     1740

caatggcaca gggcccctgt gcagtggaaa gggtcactgt caatgtggac gctgcagctg     1800

cagtggacag agctctgggc atctgtgcga gtgtgacgat gccagctgtg agcgacatga     1860

gggcatcctc tgcggaggct ttggtcgctg ccaatgtgga gtatgtcact gtcatgccaa     1920

ccgcacgggc agagcatgcg aatgcagtgg ggacatggac agttgcatca gtcccgaggg     1980

agggctctgc agtgggcatg gacgctgcaa atgcaaccgc tgccagtgct tggacggcta     2040

ctatggtgct ctatgcgacc aatgcccagg ctgcaagaca ccatgcgaga gacaccggga     2100

ctgtgcagag tgtggggcct tcaggactgg cccactggcc accaactgca gtacagcttg     2160

tgcccatacc aatgtgaccc tggccttggc ccctatcttg gatgatggct ggtgcaaaga     2220

gcggaccctg gacaaccagc tgttcttctt cttggtggag gatgacgcca gaggcacggt     2280

cgtgctcaga gtgagacccc aagaaaaggg agcagaccac acgcaggcca ttgtgctggg     2340

ctgcgtaggg ggcatcgtgg cagtggggct ggggctggtc ctggcttacc ggctctcggt     2400

ggaaatctat gaccgccggg aatacagtcg ctttgagaag gagcagcaac aactcaactg     2460

gaagcaggac agtaatcctc tctacaaaag tgccatcacg accaccatca atcctcgctt     2520

tcaagaggca gacagtccca ctctctgaag gagggaggga cacttaccca aggctcttct     2580

ccttggagga cagtgggaac tggagggtga gaggaagggt gggtctgtaa gaccttggta     2640

ggggactaat tcactggcga ggtgcggcca ccaccctact tcattttcag agtgacaccc     2700

aagagggctg cttcccatgc ctgcaacctt gcatccatct gggctacccc acccaagtat     2760

acaataaagt cttacctcag aaaaaaaaaa aaaaaaaa                             2798


<210>  17
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  18
<211>  3879
<212>  DNA
<213>  Homo sapiens

<400>  18
atcagacgcg cagaggaggc ggggccgcgg ctggtttcct gccggggggc ggctctgggc       60

cgccgagtcc cctcctcccg cccctgagga ggaggagccg ccgccacccg ccgcgcccga      120

cacccgggag gccccgccag cccgcgggag aggcccagcg ggagtcgcgg aacagcaggc      180

ccgagcccac cgcgccgggc cccggacgcc gcgcggaaaa gatgaattta caaccaattt      240

tctggattgg actgatcagt tcagtttgct gtgtgtttgc tcaaacagat gaaaatagat      300

gtttaaaagc aaatgccaaa tcatgtggag aatgtataca agcagggcca aattgtgggt      360

ggtgcacaaa ttcaacattt ttacaggaag gaatgcctac ttctgcacga tgtgatgatt      420

tagaagcctt aaaaaagaag ggttgccctc cagatgacat agaaaatccc agaggctcca      480

aagatataaa gaaaaataaa aatgtaacca accgtagcaa aggaacagca gagaagctca      540

agccagagga tattactcag atccaaccac agcagttggt tttgcgatta agatcagggg      600

agccacagac atttacatta aaattcaaga gagctgaaga ctatcccatt gacctctact      660

accttatgga cctgtcttac tcaatgaaag acgatttgga gaatgtaaaa agtcttggaa      720

cagatctgat gaatgaaatg aggaggatta cttcggactt cagaattgga tttggctcat      780

ttgtggaaaa gactgtgatg ccttacatta gcacaacacc agctaagctc aggaaccctt      840

gcacaagtga acagaactgc accagcccat ttagctacaa aaatgtgctc agtcttacta      900

ataaaggaga agtatttaat gaacttgttg gaaaacagcg catatctgga aatttggatt      960

ctccagaagg tggtttcgat gccatcatgc aagttgcagt ttgtggatca ctgattggct     1020

ggaggaatgt tacacggctg ctggtgtttt ccacagatgc cgggtttcac tttgctggag     1080

atgggaaact tggtggcatt gttttaccaa atgatggaca atgtcacctg gaaaataata     1140

tgtacacaat gagccattat tatgattatc cttctattgc tcaccttgtc cagaaactga     1200

gtgaaaataa tattcagaca atttttgcag ttactgaaga atttcagcct gtttacaagg     1260

agctgaaaaa cttgatccct aagtcagcag taggaacatt atctgcaaat tctagcaatg     1320

taattcagtt gatcattgat gcatacaatt ccctttcctc agaagtcatt ttggaaaacg     1380

gcaaattgtc agaaggcgta acaataagtt acaaatctta ctgcaagaac ggggtgaatg     1440

gaacagggga aaatggaaga aaatgttcca atatttccat tggagatgag gttcaatttg     1500

aaattagcat aacttcaaat aagtgtccaa aaaaggattc tgacagcttt aaaattaggc     1560

ctctgggctt tacggaggaa gtagaggtta ttcttcagta catctgtgaa tgtgaatgcc     1620

aaagcgaagg catccctgaa agtcccaagt gtcatgaagg aaatgggaca tttgagtgtg     1680

gcgcgtgcag gtgcaatgaa gggcgtgttg gtagacattg tgaatgcagc acagatgaag     1740

ttaacagtga agacatggat gcttactgca ggaaagaaaa cagttcagaa atctgcagta     1800

acaatggaga gtgcgtctgc ggacagtgtg tttgtaggaa gagggataat acaaatgaaa     1860

tttattctgg caaattctgc gagtgtgata atttcaactg tgatagatcc aatggcttaa     1920

tttgtggagg aaatggtgtt tgcaagtgtc gtgtgtgtga gtgcaacccc aactacactg     1980

gcagtgcatg tgactgttct ttggatacta gtacttgtga agccagcaac ggacagatct     2040

gcaatggccg gggcatctgc gagtgtggtg tctgtaagtg tacagatccg aagtttcaag     2100

ggcaaacgtg tgagatgtgt cagacctgcc ttggtgtctg tgctgagcat aaagaatgtg     2160

ttcagtgcag agccttcaat aaaggagaaa agaaagacac atgcacacag gaatgttcct     2220

attttaacat taccaaggta gaaagtcggg acaaattacc ccagccggtc caacctgatc     2280

ctgtgtccca ttgtaaggag aaggatgttg acgactgttg gttctatttt acgtattcag     2340

tgaatgggaa caacgaggtc atggttcatg ttgtggagaa tccagagtgt cccactggtc     2400

cagacatcat tccaattgta gctggtgtgg ttgctggaat tgttcttatt ggccttgcat     2460

tactgctgat atggaagctt ttaatgataa ttcatgacag aagggagttt gctaaatttg     2520

aaaaggagaa aatgaatgcc aaatgggaca cgggtgaaaa tcctatttat aagagtgccg     2580

taacaactgt ggtcaatccg aagtatgagg gaaaatgagt actgcccgtg caaatcccac     2640

aacactgaat gcaaagtagc aatttccata gtcacagtta ggtagcttta gggcaatatt     2700

gccatggttt tactcatgtg caggttttga aaatgtacaa tatgtataat ttttaaaatg     2760

ttttattatt ttgaaaataa tgttgtaatt catgccaggg actgacaaaa gacttgagac     2820

aggatggtta ctcttgtcag ctaaggtcac attgtgcctt tttgaccttt tcttcctgga     2880

ctattgaaat caagcttatt ggattaagtg atatttctat agcgattgaa agggcaatag     2940

ttaaagtaat gagcatgatg agagtttctg ttaatcatgt attaaaactg atttttagct     3000

ttacaaatat gtcagtttgc agttatgcag aatccaaagt aaatgtcctg ctagctagtt     3060

aaggattgtt ttaaatctgt tattttgcta tttgcctgtt agacatgact gatgacatat     3120

ctgaaagaca agtatgttga gagttgctgg tgtaaaatac gtttgaaata gttgatctac     3180

aaaggccatg ggaaaaattc agagagttag gaaggaaaaa ccaatagctt taaaacctgt     3240

gtgccatttt aagagttact taatgtttgg taacttttat gccttcactt tacaaattca     3300

agccttagat aaaagaaccg agcaattttc tgctaaaaag tccttgattt agcactattt     3360

acatacaggc catactttac aaagtatttg ctgaatgggg accttttgag ttgaatttat     3420

tttattattt ttattttgtt taatgtctgg tgctttctgt cacctcttct aatcttttaa     3480

tgtatttgtt tgcaattttg gggtaagact ttttttatga gtactttttc tttgaagttt     3540

tagcggtcaa tttgcctttt taatgaacat gtgaagttat actgtggcta tgcaacagct     3600

ctcacctacg cgagtcttac tttgagttag tgccataaca gaccactgta tgtttacttc     3660

tcaccatttg agttgcccat cttgtttcac actagtcaca ttcttgtttt aagtgccttt     3720

agttttaaca gttcactttt tacagtgcta tttactgaag ttatttatta aatatgccta     3780

aaatacttaa atcggatgtc ttgactctga tgtattttat caggttgtgt gcatgaaatt     3840

tttatagatt aaagaagttg aggaaaagca aaaaaaaaa                            3879


<210>  19
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu Pro Val 
1               5                   10                  15      


Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg Leu Ala 
            20                  25                  30          


Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp Thr Ser 
        35                  40                  45              


Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr Val Arg 
    50                  55                  60                  


Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly Ser Cys 
65                  70                  75                  80  


Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr Ala Phe 
                85                  90                  95      


Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly Asp Pro 
            100                 105                 110         


Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro Asn Ala 
        115                 120                 125             


Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly Ala Gln 
    130                 135                 140                 


Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln Gly Asp 
145                 150                 155                 160 


Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro Pro Leu 
                165                 170                 175     


Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met Arg Leu 
            180                 185                 190         


Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu His Ser 
        195                 200                 205             


Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp 
    210                 215                 220                 


Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln Glu Pro Pro Asp 
225                 230                 235                 240 


Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro Ala Pro 
                245                 250                 255     


Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr Arg Thr 
            260                 265                 270         


Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu Val Ile 
        275                 280                 285             


Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala Ala Leu 
    290                 295                 300                 


Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu Pro Thr 
305                 310                 315                 320 


Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp Thr His 
                325                 330                 335     


Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp Ala Gly 
            340                 345                 350         


Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
        355                 360                 


<210>  20
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala Lys Ser Cys Gly 
1               5                   10                  15      


Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys Thr Asn Ser Thr 
            20                  25                  30          


Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys Asp Asp Leu Glu 
        35                  40                  45              


Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile Glu Asn Pro Arg 
    50                  55                  60                  


Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr Asn Arg Ser Lys 
65                  70                  75                  80  


Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr Gln Ile Gln Pro 
                85                  90                  95      


Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro Gln Thr Phe Thr 
            100                 105                 110         


Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp Leu Tyr Tyr Leu 
        115                 120                 125             


Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu Asn Val Lys Ser 
    130                 135                 140                 


Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile Thr Ser Asp Phe 
145                 150                 155                 160 


Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val Met Pro Tyr Ile 
                165                 170                 175     


Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr Ser Glu Gln Asn 
            180                 185                 190         


Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser Leu Thr Asn Lys 
        195                 200                 205             


Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg Ile Ser Gly Asn 
    210                 215                 220                 


Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met Gln Val Ala Val 
225                 230                 235                 240 


Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg Leu Leu Val Phe 
                245                 250                 255     


Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly Lys Leu Gly Gly 
            260                 265                 270         


Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu Asn Asn Met Tyr 
        275                 280                 285             


Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala His Leu Val Gln 
    290                 295                 300                 


Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala Val Thr Glu Glu 
305                 310                 315                 320 


Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile Pro Lys Ser Ala 
                325                 330                 335     


Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile Gln Leu Ile Ile 
            340                 345                 350         


Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu Glu Asn Gly Lys 
        355                 360                 365             


Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr Cys Lys Asn Gly 
    370                 375                 380                 


Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser Asn Ile Ser Ile 
385                 390                 395                 400 


Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser Asn Lys Cys Pro 
                405                 410                 415     


Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu Gly Phe Thr Glu 
            420                 425                 430         


Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys Glu Cys Gln Ser 
        435                 440                 445             


Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly Asn Gly Thr Phe 
    450                 455                 460                 


Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val Gly Arg His Cys 
465                 470                 475                 480 


Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met Asp Ala Tyr Cys 
                485                 490                 495     


Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn Gly Glu Cys Val 
            500                 505                 510         


Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr Asn Glu Ile Tyr 
        515                 520                 525             


Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys Asp Arg Ser Asn 
    530                 535                 540                 


Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys Arg Val Cys Glu 
545                 550                 555                 560 


Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys Ser Leu Asp Thr 
                565                 570                 575     


Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn Gly Arg Gly Ile 
            580                 585                 590         


Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys Phe Gln Gly Gln 
        595                 600                 605             


Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys Ala Glu His Lys 
    610                 615                 620                 


Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu Lys Lys Asp Thr 
625                 630                 635                 640 


Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys Val Glu Ser Arg 
                645                 650                 655     


Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val Ser His Cys Lys 
            660                 665                 670         


Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr Tyr Ser Val Asn 
        675                 680                 685             


Gly Asn Asn Glu Val Met Val His Val Val Glu Asn Pro Glu Cys Pro 
    690                 695                 700                 


Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val Val Ala Gly Ile 
705                 710                 715                 720 


Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys Leu Leu Met Ile 
                725                 730                 735     


Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys Glu Lys Met Asn 
            740                 745                 750         


Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr 
        755                 760                 765             


Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
    770                 775             


<210>  21
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Pro Leu Gln Leu Leu Leu Leu Leu Ile Leu Leu Gly Pro Gly Asn 
1               5                   10                  15      


Ser Leu Gln Leu Trp Asp Thr Trp Ala Asp Glu Ala Glu Lys Ala Leu 
            20                  25                  30          


Gly Pro Leu Leu Ala Arg Asp Arg Arg Gln Ala Thr Glu Tyr Glu Tyr 
        35                  40                  45              


Leu Asp Tyr Asp Phe Leu Pro Glu Thr Glu Pro Pro Glu Met Leu Arg 
    50                  55                  60                  


Asn Ser Thr Asp Thr Thr Pro Leu Thr Gly Pro Gly Thr Pro Glu Ser 
65                  70                  75                  80  


Thr Thr Val Glu Pro Ala Ala Arg Arg Ser Thr Gly Leu Asp Ala Gly 
                85                  90                  95      


Gly Ala Val Thr Glu Leu Thr Thr Glu Leu Ala Asn Met Gly Asn Leu 
            100                 105                 110         


Ser Thr Asp Ser Ala Ala Met Glu Ile Gln Thr Thr Gln Pro Ala Ala 
        115                 120                 125             


Thr Glu Ala Gln Thr Thr Gln Pro Val Pro Thr Glu Ala Gln Thr Thr 
    130                 135                 140                 


Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Arg Leu Thr Ala Thr Glu 
145                 150                 155                 160 


Ala Gln Thr Thr Pro Leu Ala Ala Thr Glu Ala Gln Thr Thr Pro Pro 
                165                 170                 175     


Ala Ala Thr Glu Ala Gln Thr Thr Gln Pro Thr Gly Leu Glu Ala Gln 
            180                 185                 190         


Thr Thr Ala Pro Ala Ala Met Glu Ala Gln Thr Thr Ala Pro Ala Ala 
        195                 200                 205             


Met Glu Ala Gln Thr Thr Pro Pro Ala Ala Met Glu Ala Gln Thr Thr 
    210                 215                 220                 


Gln Thr Thr Ala Met Glu Ala Gln Thr Thr Ala Pro Glu Ala Thr Glu 
225                 230                 235                 240 


Ala Gln Thr Thr Gln Pro Thr Ala Thr Glu Ala Gln Thr Thr Pro Leu 
                245                 250                 255     


Ala Ala Met Glu Ala Leu Ser Thr Glu Pro Ser Ala Thr Glu Ala Leu 
            260                 265                 270         


Ser Met Glu Pro Thr Thr Lys Arg Gly Leu Phe Ile Pro Phe Ser Val 
        275                 280                 285             


Ser Ser Val Thr His Lys Gly Ile Pro Met Ala Ala Ser Asn Leu Ser 
    290                 295                 300                 


Val Asn Tyr Pro Val Gly Ala Pro Asp His Ile Ser Val Lys Gln Cys 
305                 310                 315                 320 


Leu Leu Ala Ile Leu Ile Leu Ala Leu Val Ala Thr Ile Phe Phe Val 
                325                 330                 335     


Cys Thr Val Val Leu Ala Val Arg Leu Ser Arg Lys Gly His Met Tyr 
            340                 345                 350         


Pro Val Arg Asn Tyr Ser Pro Thr Glu Met Val Cys Ile Ser Ser Leu 
        355                 360                 365             


Leu Pro Asp Gly Gly Glu Gly Pro Ser Ala Thr Ala Asn Gly Gly Leu 
    370                 375                 380                 


Ser Lys Ala Lys Ser Pro Gly Leu Thr Pro Glu Pro Arg Glu Asp Arg 
385                 390                 395                 400 


Glu Gly Asp Asp Leu Thr Leu His Ser Phe Leu Pro 
                405                 410         


<210>  22
<211>  2573
<212>  DNA
<213>  Homo sapiens

<400>  22
acacacagcc attgggggtt gctcggatcc gggactgccg cagggggtgc cacagcagtg       60

cctggcagcg tgggctggga ccttgtcact aaagcagaga agccacttct tctgggccca      120

cgaggcagct gtcccatgct ctgctgagca cggtggtgcc atgcctctgc aactcctcct      180

gttgctgatc ctactgggcc ctggcaacag cttgcagctg tgggacacct gggcagatga      240

agccgagaaa gccttgggtc ccctgcttgc ccgggaccgg agacaggcca ccgaatatga      300

gtacctagat tatgatttcc tgccagaaac ggagcctcca gaaatgctga ggaacagcac      360

tgacaccact cctctgactg ggcctggaac ccctgagtct accactgtgg agcctgctgc      420

aaggcgttct actggcctgg atgcaggagg ggcagtcaca gagctgacca cggagctggc      480

caacatgggg aacctgtcca cggattcagc agctatggag atacagacca ctcaaccagc      540

agccacggag gcacagacca ctcaaccagt gcccacggag gcacagacca ctccactggc      600

agccacagag gcacagacaa ctcgactgac ggccacggag gcacagacca ctccactggc      660

agccacagag gcacagacca ctccaccagc agccacggaa gcacagacca ctcaacccac      720

aggcctggag gcacagacca ctgcaccagc agccatggag gcacagacca ctgcaccagc      780

agccatggaa gcacagacca ctccaccagc agccatggag gcacagacca ctcaaaccac      840

agccatggag gcacagacca ctgcaccaga agccacggag gcacagacca ctcaacccac      900

agccacggag gcacagacca ctccactggc agccatggag gccctgtcca cagaacccag      960

tgccacagag gccctgtcca tggaacctac taccaaaaga ggtctgttca tacccttttc     1020

tgtgtcctct gttactcaca agggcattcc catggcagcc agcaatttgt ccgtcaacta     1080

cccagtgggg gccccagacc acatctctgt gaagcagtgc ctgctggcca tcctaatctt     1140

ggcgctggtg gccactatct tcttcgtgtg cactgtggtg ctggcggtcc gcctctcccg     1200

caagggccac atgtaccccg tgcgtaatta ctcccccacc gagatggtct gcatctcatc     1260

cctgttgcct gatgggggtg aggggccctc tgccacagcc aatgggggcc tgtccaaggc     1320

caagagcccg ggcctgacgc cagagcccag ggaggaccgt gagggggatg acctcaccct     1380

gcacagcttc ctcccttagc tcactctgcc atctgttttg gcaagacccc acctccacgg     1440

gctctcctgg gccacccctg agtgcccaga ccccattcca cagctctggg cttcctcgga     1500

gacccctggg gatggggatc ttcagggaag gaactctggc cacccaaaca ggacaagagc     1560

agcctggggc caagcagacg ggcaagtgga gccacctctt tcctccctcc gcggatgaag     1620

cccagccaca tttcagccga ggtccaaggc aggaggccat ttacttgaga cagattctct     1680

cctttttcct gtcccccatc ttctctgggt ccctctaaca tctcccatgg ctctccccgc     1740

ttctcctggt cactggagtc tcctccccat gtacccaagg aagatggagc tcccccatcc     1800

cacacgcact gcactgccat tgtcttttgg ttgccatggt caccaaacag gaagtggaca     1860

ttctaaggga ggagtactga agagtgacgg acttctgagg ctgtttcctg ctgctcctct     1920

gacttggggc agcttgggtc ttcttgggca cctctctggg aaaacccagg gtgaggttca     1980

gcctgtgagg gctgggatgg gtttcgtggg cccaagggca gacctttctt tgggactgtg     2040

tggaccaagg agcttccatc tagtgacaag tgacccccag ctatcgcctc ttgccttccc     2100

ctgtggccac tttccagggt ggactctgtc ttgttcactg cagtatccca actgcaggtc     2160

cagtgcaggc aataaatatg tgatggacaa acgatagcgg aatccttcaa ggtttcaagg     2220

ctgtctcctt caggcagcct tcccggaatt ctccatccct cagtgcagga tgggggctgg     2280

tcctcagctg tctgccctca gcccctggcc ccccaggaag cctctttcat gggctgttag     2340

gttgacttca gttttgcctc ttggacaaca gggggtcttg tacatccttg ggtgaccagg     2400

aaaagttcag gctatggggg gccaaaggga gggctgcccc ttccccacca gtgaccactt     2460

tattccactt cctccattac ccagttttgg cccacagagt ttggtccccc ccaaacctcg     2520

gaccaatatc cctctaaaca tcaatctatc ctcctgttaa agaaaaaaaa aaa            2573


<210>  23
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Gly Glu Asp Pro Tyr Tyr Thr Glu Asn Gly Gly Gly 
                325                 330                 335     


Gln Gly Tyr Ser Ser Gly Pro Gly Thr Ser Pro Glu Ala Gln Gly Lys 
            340                 345                 350         


Ala Ser Val Asn Arg Gly Ala Gln Glu Asn Gly Thr Gly Gln Ala Thr 
        355                 360                 365             


Ser Arg Asn Gly His Ser Ala Arg Gln His Val Val Ala Asp Thr Glu 
    370                 375                 380                 


Leu 
385 


<210>  24
<211>  2621
<212>  DNA
<213>  Homo sapiens

<400>  24
ccttttttgg cctcgacggc ggcaacccag cctccctcct aacgccctcc gcctttggga       60

ccaaccaggg gagctcaagt tagtagcagc caaggagagg cgctgccttg ccaagactaa      120

aaagggaggg gagaagagag gaaaaaagca agaatccccc acccctctcc cgggcggagg      180

gggcgggaag agcgcgtcct ggccaagccg agtagtgtct tccactcggt gcgtctctct      240

aggagccgcg cgggaaggat gctggtccgc aggggcgcgc gcgcagggcc caggatgccg      300

cggggctgga ccgcgctttg cttgctgagt ttgctgcctt ctgggttcat gagtcttgac      360

aacaacggta ctgctacccc agagttacct acccagggaa cattttcaaa tgtttctaca      420

aatgtatcct accaagaaac tacaacacct agtacccttg gaagtaccag cctgcaccct      480

gtgtctcaac atggcaatga ggccacaaca aacatcacag aaacgacagt caaattcaca      540

tctacctctg tgataacctc agtttatgga aacacaaact cttctgtcca gtcacagacc      600

tctgtaatca gcacagtgtt caccacccca gccaacgttt caactccaga gacaaccttg      660

aagcctagcc tgtcacctgg aaatgtttca gacctttcaa ccactagcac tagccttgca      720

acatctccca ctaaacccta tacatcatct tctcctatcc taagtgacat caaggcagaa      780

atcaaatgtt caggcatcag agaagtgaaa ttgactcagg gcatctgcct ggagcaaaat      840

aagacctcca gctgtgcgga gtttaagaag gacaggggag agggcctggc ccgagtgctg      900

tgtggggagg agcaggctga tgctgatgct ggggcccagg tatgctccct gctccttgcc      960

cagtctgagg tgaggcctca gtgtctactg ctggtcttgg ccaacagaac agaaatttcc     1020

agcaaactcc aacttatgaa aaagcaccaa tctgacctga aaaagctggg gatcctagat     1080

ttcactgagc aagatgttgc aagccaccag agctattccc aaaagaccct gattgcactg     1140

gtcacctcgg gagccctgct ggctgtcttg ggcatcactg gctatttcct gatgaatcgc     1200

cgcagctgga gccccacagg agaaaggctg ggcgaagacc cttattacac ggaaaacggt     1260

ggaggccagg gctatagctc aggacctggg acctcccctg aggctcaggg aaaggccagt     1320

gtgaaccgag gggctcagga aaacgggacc ggccaggcca cctccagaaa cggccattca     1380

gcaagacaac acgtggtggc tgataccgaa ttgtgactcg gctaggtggg gcaaggctgg     1440

gcagtgtccg agagagcacc cctctctgca tctgaccacg tgctaccccc atgctggagg     1500

tgacatctct tacgcccaac ccttccccac tgcacacacc tcagaggctg ttcttggggc     1560

cctacacctt gaggaggggc aggtaaactc ctgtccttta cacattcggc tccctggagc     1620

cagactctgg tcttctttgg gtaaacgtgt gacgggggaa agccaaggtc tggagaagct     1680

cccaggaaca atcgatggcc ttgcagcact cacacaggac ccccttcccc taccccctcc     1740

tctctgccgc aatacaggaa cccccagggg aaagatgagc ttttctaggc tacaattttc     1800

tcccaggaag ctttgatttt taccgtttct tccctgtatt ttctttctct actttgagga     1860

aaccaaagta accttttgca cctgctctct tgtaatgata tagccagaaa aacgtgttgc     1920

cttgaaccac ttccctcatc tctcctccaa gacactgtgg acttggtcac cagctcctcc     1980

cttgttctct aagttccact gagctccatg tgccccctct accatttgca gagtcctgca     2040

cagttttctg gctggagcct agaacaggcc tcccaagttt taggacaaac agctcagttc     2100

tagtctctct ggggccacac agaaactctt tttgggctcc tttttctccc tctggatcaa     2160

agtaggcagg accatgggac caggtcttgg agctgagcct ctcacctgta ctcttccgaa     2220

aaatcctctt cctctgaggc tggatcctag ccttatcctc tgatctccat ggcttcctcc     2280

tccctcctgc cgactcctgg gttgagctgt tgcctcagtc ccccaacaga tgcttttctg     2340

tctctgcctc cctcaccctg agccccttcc ttgctctgca cccccatatg gtcatagccc     2400

agatcagctc ctaaccctta tcaccagctg cctcttctgt gggtgaccca ggtccttgtt     2460

tgctgttgat ttctttccag aggggttgag cagggatcct ggtttcaatg acggttggaa     2520

atagaaattt ccagagaaga gagtattggg tagatatttt ttctgaatac aaagtgatgt     2580

gtttaaatac tgcaattaaa gtgatactga aacacaaaaa a                         2621


<210>  25
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Lys Phe Phe Met Val Leu Leu Pro Ala Ser Leu Ala Ser Thr Ser 
1               5                   10                  15      


Leu Ala Ile Leu Asp Val Glu Ser Gly Leu Leu Pro Gln Leu Ser Val 
            20                  25                  30          


Leu Leu Ser Asn Arg Leu Arg Gly Lys Thr Cys Gln Thr Gly Pro 
        35                  40                  45          


<210>  26
<211>  297
<212>  DNA
<213>  Homo sapiens

<400>  26
aactgatcct gctacagctc caccatgaag ttcttcatgg tcctgctgcc agccagccta       60

gcctccacct ctctcgccat ccttgatgtt gaatctggcc tccttccaca actctcagta      120

ctcctcagca accgcctcag agggaaaact tgccaaactg gcccataaaa tcgggaagaa      180

tctggacaaa gcattgaaag gaatcataaa ctatctgaaa aacctaatcc ctagcgccaa      240

tgatgtcatg aggccctaat gatgagggtg cctgaattcc aggctaggct gtgggag         297


<210>  27
<211>  6082
<212>  DNA
<213>  Homo sapiens

<400>  27
ataacgtctt tgtcactaaa atgttcccca ggggccttcg gcgagtcttt ttgtttggtt       60

ttttgttttt aatctgtggc tcttgataat ttatctagtg gttgcctaca cctgaaaaac      120

aagacacagt gtttaactat caacgaaaga actggacggc tccccgccgc agtcccactc      180

cccgagtttg tggctggcat ttgggccacg ccgggctggg cggtcacagc gaggggcgcg      240

cagtttgggg tcacacagct ccgcttctag gccccaacca ccgttaaaag gggaagcccg      300

tgccccatca ggtccgctct tgctgagccc agagccatcc cgcgctctgc gggctgggag      360

gcccgggcca ggacgcgagt cctgcgcagc cgaggttccc cagcgccccc tgcagccgcg      420

cgtaggcaga gacggagccc ggccctgcgc ctccgcacca cgcccgggac cccacccagc      480

ggcccgtacc cggagaagca gcgcgagcac ccgaagctcc cggctggcgg cagaaaccgg      540

gagtggggcc gggcgagtgc gcggcatccc aggccggccc gaacgctccg cccgcggtgg      600

gccgacttcc cctcctcttc cctctctcct tcctttagcc cgctggcgcc ggacacgctg      660

cgcctcatct cttggggcgt tcttccccgt tggccaaccg tcgcatcccg tgcaactttg      720

gggtagtggc cgtttagtgt tgaatgttcc ccaccgagag cgcatggctt gggaagcgag      780

gcgcgaaccc ggcccccgaa gggccgccgt ccgggagacg gtgatgctgt tgctgtgcct      840

gggggtcccg accggccgcc cctacaacgt ggacactgag agcgcgctgc tttaccaggg      900

cccccacaac acgctgttcg gctactcggt cgtgctgcac agccacgggg cgaaccgatg      960

gctcctagtg ggtgcgccca ctgccaactg gctcgccaac gcttcagtga tcaatcccgg     1020

ggcgatttac agatgcagga tcggaaagaa tcccggccag acgtgcgaac agctccagct     1080

gggtagccct aatggagaac cttgtggaaa gacttgtttg gaagagagag acaatcagtg     1140

gttgggggtc acactttcca gacagccagg agaaaatgga tccatcgtga cttgtgggca     1200

tagatggaaa aatatatttt acataaagaa tgaaaataag ctccccactg gtggttgcta     1260

tggagtgccc cctgatttac gaacagaact gagtaaaaga atagctccgt gttatcaaga     1320

ttatgtgaaa aaatttggag aaaattttgc atcatgtcaa gctggaatat ccagttttta     1380

cacaaaggat ttaattgtga tgggggcccc aggatcatct tactggactg gctctctttt     1440

tgtctacaat ataactacaa ataaatacaa ggctttttta gacaaacaaa atcaagtaaa     1500

atttggaagt tatttaggat attcagtcgg agctggtcat tttcggagcc agcatactac     1560

cgaagtagtc ggaggagctc ctcaacatga gcagattggt aaggcatata tattcagcat     1620

tgatgaaaaa gaactaaata tcttacatga aatgaaaggt aaaaagcttg gatcgtactt     1680

tggagcttct gtctgtgctg tggacctcaa tgcagatggc ttctcagatc tgctcgtggg     1740

agcacccatg cagagcacca tcagagagga aggaagagtg tttgtgtaca tcaactctgg     1800

ctcgggagca gtaatgaatg caatggaaac aaacctcgtt ggaagtgaca aatatgctgc     1860

aagatttggg gaatctatag ttaatcttgg cgacattgac aatgatggct ttgaagatgt     1920

tgctatcgga gctccacaag aagatgactt gcaaggtgct atttatattt acaatggccg     1980

tgcagatggg atctcgtcaa ccttctcaca gagaattgaa ggacttcaga tcagcaaatc     2040

gttaagtatg tttggacagt ctatatcagg acaaattgat gcagataata atggctatgt     2100

agatgtagca gttggtgctt ttcggtctga ttctgctgtc ttgctaagga caagacctgt     2160

agtaattgtt gacgcttctt taagccaccc tgagtcagta aatagaacga aatttgactg     2220

tgttgaaaat ggatggcctt ctgtgtgcat agatctaaca ctttgtttct catataaggg     2280

caaggaagtt ccaggttaca ttgttttgtt ttataacatg agtttggatg tgaacagaaa     2340

ggcagagtct ccaccaagat tctatttctc ttctaatgga acttctgacg tgattacagg     2400

aagcatacag gtgtccagca gagaagctaa ctgtagaaca catcaagcat ttatgcggaa     2460

agatgtgcgg gacatcctca ccccaattca gattgaagct gcttaccacc ttggtcctca     2520

tgtcatcagt aaacgaagta cagaggaatt cccaccactt cagccaattc ttcagcagaa     2580

gaaagaaaaa gacataatga aaaaaacaat aaactttgca aggttttgtg cccatgaaaa     2640

ttgttctgct gatttacagg tttctgcaaa gattgggttt ttgaagcccc atgaaaataa     2700

aacatatctt gctgttggga gtatgaagac attgatgttg aatgtgtcct tgtttaatgc     2760

tggagatgat gcatatgaaa cgactctaca tgtcaaacta cccgtgggtc tttatttcat     2820

taagatttta gagctggaag agaagcaaat aaactgtgaa gtcacagata actctggcgt     2880

ggtacaactt gactgcagta ttggctatat atatgtagat catctctcaa ggatagatat     2940

tagctttctc ctggatgtga gctcactcag cagagcggaa gaggacctca gtatcacagt     3000

gcatgctacc tgtgaaaatg aagaggaaat ggacaatcta aagcacagca gagtgactgt     3060

agcaatacct ttaaaatatg aggttaagct gactgttcat gggtttgtaa acccaacttc     3120

atttgtgtat ggatcaaatg atgaaaatga gcctgaaacg tgcatggtgg agaaaatgaa     3180

cttaactttc catgttatca acactggcaa tagtatggct cccaatgtta gtgtggaaat     3240

aatggtacca aattctttta gcccccaaac tgataagctg ttcaacattt tggatgtcca     3300

gactactact ggagaatgcc actttgaaaa ttatcaaaga gtgtgtgcat tagagcagca     3360

aaagagtgca atgcagacct tgaaaggcat agtccggttc ttgtccaaga ctgataagag     3420

gctattgtac tgcataaaag ctgatccaca ttgtttaaat ttcttgtgta attttgggaa     3480

aatggaaagt ggaaaagaag ccagtgttca tatccaactg gaaggccggc catccatttt     3540

agaaatggat gagacttcag cactcaagtt tgaaataaga gcaacaggtt ttccagagcc     3600

aaatccaaga gtaattgaac taaacaagga tgagaatgtt gcgcatgttc tactggaagg     3660

actacatcat caaagaccca aacgttattt caccatagtg attatttcaa gtagcttgct     3720

acttggactt attgtacttc tgttgatctc atatgttatg tggaaggctg gcttctttaa     3780

aagacaatac aaatctatcc tacaagaaga aaacagaaga gacagttgga gttatatcaa     3840

cagtaaaagc aatgatgatt aaggacttct ttcaaattga gagaatggaa aacagactca     3900

ggttgtagta aagaaattta aaagacactg tttacaagaa aaaatgaatt ttgtttggac     3960

ttcttttact catgatcttg tgacatatta tgtcttcatg caaggggaaa atctcagcaa     4020

tgattactct ttgagataga agaactgcaa aggtaataat acagccaaag ataatctctc     4080

agcttttaaa tgggtagaga aacactaaag cattcaattt attcaagaaa agtaagccct     4140

tgaagatatc ttgaaatgaa agtataactg agttaaatta tactggagaa gtcttagact     4200

tgaaatacta cttaccatat gtgcttgcct cagtaaaatg aaccccactg ggtgggcaga     4260

ggttcatttc aaatacatct ttgatacttg ttcaaaatat gttctttaaa aatataattt     4320

tttagagagc tgttcccaaa ttttctaacg agtggaccat tatcacttta aagcccttta     4380

tttataatac atttcctacg ggctgtgttc caacaaccat tttttttcag cagactatga     4440

atattatagt attataggcc aaactggcaa acttcagact gaacatgtac actggtttga     4500

gcttagtgaa attacttctg gataattatt tttttataat tatggatttc accatctttc     4560

tttctgtata tatacatgtg tttttatgta ggtatatatt taccattctt cctatctatt     4620

cttcctataa cacaccttta tcaagcatac ccaggagtaa tcttcaaatc ttttgttata     4680

ttctgaaaca aaagattgtg agtgttgcac tttacctgat acacgctgat ttagaaaata     4740

cagaaaccat acctcactaa taactttaaa atcaaagctg tgcaaagact agggggccta     4800

tacttcatat gtattatgta ctatgtaaaa tattgactat cacacaacta tttccttgga     4860

tgtaattctt tgttaccctt tacaagtata agtgttacct tacatggaaa cgaagaaaca     4920

aaattcataa atttaaattc ataaatttag ctgaaagata ctgattcaat ttgtatacag     4980

tgaatataaa tgagacgaca gcaaaatttt catgaaatgt aaaatatttt tatagtttgt     5040

tcatactata tgaggttcta ttttaaatga ctttctggat tttaaaaaat ttctttaaat     5100

acaatcattt ttgtaatatt tattttatgc ttatgatcta gataattgca gaatatcatt     5160

ttatctgact ctgccttcat aagagagctg tggccgaatt ttgaacatct gttataggga     5220

gtgatcaaat tagaaggcaa tgtggaaaaa caattctggg aaagatttct ttatatgaag     5280

tccctgccac tagccagcca tcctaattga tgaaagttat ctgttcacag gcctgcagtg     5340

atggtgagga atgttctgag atttgcgaag gcatttgagt agtgaaatgt aagcacaaaa     5400

cctcctgaac ccagagtgtg tatacacagg aataaacttt atgacattta tgtattttta     5460

aaaaactttg tatcgttata aaaaggctag tcattctttc aggagaacat ctaggatcat     5520

agatgaaaaa tcaagccccg atttagaact gtcttctcca ggatggtctc taaggaaatt     5580

tacatttggt tctttcctac tcagaactac tcagaaacaa ctatatattt caggttatct     5640

gagcacagtg aaagcagagt actatggttg tccaacacag gcctctcaga tacaagggga     5700

acacaattac atattgggct agattttgcc cagttcaaaa tagtatttgt tatcaactta     5760

ctttgttact tgtatcatga attttaaaac cctaccactt taagaagaca gggatgggtt     5820

attctttttt ggcaggtagg ctatataact atgtgatttt gaaatttaac tgctctggat     5880

tagggagcag tgaatcaagg cagacttatg aaatctgtat tatatttgta acagaatata     5940

ggaaatttaa cataattgat gagctcaaat cctgaaaaat gaaagaatcc aaattatttc     6000

agaattatct aggttaaata ttgatgtatt atgatggttg caaagttttt ttgtgtgtcc     6060

aataaacaca ttgtaaaaaa aa                                              6082


