                         SEQUENCE LISTING

<110>  Cornell University
 
<120>  AAV-DIRECTED PERSISTENT EXPRESSION OF AN ANTI-NICOTINE ANTIBODY 
       GENE FOR SMOKING CESSATION

<130>  712129

<150>  US 61/604,203
<151>  2012-02-28

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  2200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gccaccatgg aatggacctg ggtctttctc ttcctcctgt cagtgcctgc aggtgtccac       60

tcccagtttc agctgcagca gtctggaact gagctgatga agcctggggc ctcagtgaag      120

atatcctgca aggcttctgc ctacacattc aatacctact ggatagagtg gattaaacag      180

aggcctggac ttggccttga gtggattgga gaaattttac ctggaagtgg aagtactcac      240

tacaatgaga aattcaaggc caaggccaca ttcactgcag atacatcctc caacacagcc      300

ttcatgcaac tcaacagcct gacatctgag gactctgccg tctattactg tgcaacgggt      360

gggtcctatg gtaactacga ttacttcgat gtctggggcg ctgggaccac ggtcaccgtc      420

tcctcagcca aaacgacacc cccatctgtc tatccactgg cccctggatc tgctgcccaa      480

actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga gccagtgaca      540

gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc tgtcctgcag      600

tctgacctct acactctgag cagctcagtg actgtcccct ccagcacctg gcccagcgag      660

accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa gaaaattgtg      720

cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc atctgtcttc      780

atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa ggtcacgtgt      840

gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt tgtagatgat      900

gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag cactttccgc      960

tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga gttcaaatgc     1020

agggtcaaca gtgcagcttt ccctgccccc atcgagaaaa ccatctccaa aaccaaaggc     1080

agaccgaagg ctccacaggt gtacaccatt ccacctccca aggagcagat ggccaaggat     1140

aaagtcagtc tgacctgcat gataacagac ttcttccctg aagacattac tgtggagtgg     1200

cagtggaatg ggcagccagc ggagaactac aagaacactc agcccatcat ggacacagat     1260

ggctcttact tcgtctacag caagctcaat gtgcagaaga gcaactggga ggcaggaaat     1320

actttcacct gctctgtgtt acatgagggc ctgcacaacc accatactga gaagagcctc     1380

tcccactctc ctggtaaaag agccaagagg gcacctgtga aacagacttt gaattttgac     1440

cttctcaagt tggcgggaga cgtcgagtcc aaccctgggc ccatgaagtt gcctgttagg     1500

ctgttggtgc tgatgttctg gattcctgct tccagcagtg atgttgtgat gacccaaagt     1560

ccactctccc tgcctgtcag tcttggagat cgagccgcca tatcttgcag atctagtcag     1620

agccttgtaa acagttatgg aatcacctat ttatattggt atttgcagaa gcccggccag     1680

tctccaaagg tcctgattta caaagtttcc aaacgatttt ctggggtccc agacaggttc     1740

agtggcagtg gatcagggac agatttcaca ctcaagatca gcagagtgga gactgaggat     1800

ctgggagttt atttctgctc tcaaacttca cattttcctc ccacgttcgg tgctgggacc     1860

aagctggagt tgaaacgggc tgatgctgca ccaactgtat ccatcttccc accatccagt     1920

gagcagttaa catctggagg tgcctcagtc gtgtgcttct tgaacaactt ctaccccaaa     1980

gacatcaatg tcaagtggaa gattgatggc agtgaacgac aaaatggcgt cctgaacagt     2040

tggactgatc aggacagcaa agacagcacc tacagcatga gcagcaccct cacgttgacc     2100

aaggacgagt atgaacgaca taacagctat acctgtgagg ccactcacaa gacatcaact     2160

tcacccattg tcaagagctt caacaggaat gagtgttaga                           2200


<210>  2
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Pro Ala Gly 
1               5                   10                  15      


Val His Ser Gln Phe Gln Leu Gln Gln Ser Gly Thr Glu Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Ala Tyr Thr Phe 
        35                  40                  45              


Asn Thr Tyr Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly Leu Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr His Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ala Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Phe Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Gly Gly Ser Tyr Gly Asn Tyr Asp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     


Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 


<210>  3
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Arg Ala Ala Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val Asn Ser Tyr Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Val Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Thr Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Thr Ser His Phe Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


