                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       Fass, Deborah
       Grossman, Iris
       Ilani, Tal
       Alon, Assaf
 
<120>  COMPOSITIONS FOR INHIBITION OF QUIESCIN SULFHYDRYL OXIDASE 
       (QSOX1) AND USES OF SAME

<130>  55583

<150>  US 61/607,696
<151>  2012-03-07

<150>  US 61/665,365
<151>  2012-06-28

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  3316
<212>  DNA
<213>  Homo sapiens

<400>  1
ggaggcaggc ggtgccgcgg cgccgggacc cgactcatcc ggtgcttgcg tgtggtggtg       60

agcgcagcgc cgaggatgag gaggtgcaac agcggctccg ggccgccgcc gtcgctgctg      120

ctgctgctgc tgtggctgct cgcggttccc ggcgctaacg cggccccgcg gtcggcgctc      180

tattcgcctt ccgacccgct gacgctgctg caggcggaca cggtgcgcgg cgcggtgctg      240

ggctcccgca gcgcctgggc cgtggagttc ttcgcctcct ggtgcggcca ctgcatcgcc      300

ttcgccccga cgtggaaggc gctggccgaa gacgtcaaag cctggaggcc ggccctgtat      360

ctcgccgccc tggactgtgc tgaggagacc aacagtgcag tctgcagaga cttcaacatc      420

cctggcttcc cgactgtgag gttcttcaag gcctttacca agaacggctc gggagcagta      480

tttccagtgg ctggtgctga cgtgcagaca ctgcgggaga ggctcattga cgccctggag      540

tcccatcatg acacgtggcc cccagcctgt cccccactgg agcctgccaa gctggaggag      600

attgatggat tctttgcgag aaataacgaa gagtacctgg ctctgatctt tgaaaaggga      660

ggctcctacc tgggtagaga ggtggctctg gacctgtccc agcacaaagg cgtggcggtg      720

cgcagggtgc tgaacacaga ggccaatgtg gtgagaaagt ttggtgtcac cgacttcccc      780

tcttgctacc tgctgttccg gaatggctct gtctcccgag tccccgtgct catggaatcc      840

aggtccttct ataccgctta cctgcagaga ctctctgggc tcaccaggga ggctgcccag      900

accacagttg caccaaccac tgctaacaag atagctccca ctgtttggaa attggcagat      960

cgctccaaga tctacatggc tgacctggaa tctgcactgc actacatcct gcggatagaa     1020

gtgggcaggt tcccggtcct ggaagggcag cgcctggtgg ccctgaaaaa gtttgtggca     1080

gtgctggcca agtatttccc tggccggccc ttagtccaga acttcctgca ctccgtgaat     1140

gaatggctca agaggcagaa gagaaataaa attccctaca gtttctttaa aactgccctg     1200

gacgacagga aagagggtgc cgttcttgcc aagaaggtga actggattgg ctgccagggg     1260

agtgagccgc atttccgggg ctttccctgc tccctgtggg tcctcttcca cttcttgact     1320

gtgcaggcag ctcggcaaaa tgtagaccac tcacaggaag cagccaaggc caaggaggtc     1380

ctcccagcca tccgaggcta cgtgcactac ttcttcggct gccgagactg cgctagccac     1440

ttcgagcaga tggctgctgc ctccatgcac cgggtgggga gtcccaacgc cgctgtcctc     1500

tggctctggt ctagccacaa cagggtcaat gctcgccttg caggtgcccc cagcgaggac     1560

ccccagttcc ccaaggtgca gtggccaccc cgtgaacttt gttctgcctg ccacaatgaa     1620

cgcctggatg tgcccgtgtg ggacgtggaa gccaccctca acttcctcaa ggcccacttc     1680

tccccaagca acatcatcct ggacttccct gcagctgggt cagctgcccg gagggatgtg     1740

cagaatgtgg cagccgcccc agagctggcg atgggagccc tggagctgga aagccggaat     1800

tcaactctgg accctgggaa gcctgagatg atgaagtccc ccacaaacac caccccacat     1860

gtgccggctg agggacctga ggcaagtcga cccccgaagc tgcaccctgg cctcagagct     1920

gcaccaggcc aggagcctcc tgagcacatg gcagagcttc agaggaatga gcaggagcag     1980

ccgcttgggc agtggcactt gagcaagcga gacacagggg ctgcattgct ggctgagtcc     2040

agggctgaga agaaccgcct ctggggccct ttggaggtca ggcgcgtggg ccgcagctcc     2100

aagcagctgg tcgacatccc tgagggccag ctggaggccc gagctggacg gggccgaggc     2160

cagtggctgc aggtgctggg agggggcttc tcttacctgg acatcagcct ctgtgtgggg     2220

ctctattccc tgtccttcat gggcctgctg gccatgtaca cctacttcca ggccaagata     2280

agggccctga agggccatgc tggccaccct gcagcctgaa ccacctgggg aggaggcggg     2340

agagggagct gccatctcta ggcacctcaa gccccctgac cccattccct cccctcccac     2400

cccttgctcc ttgtctggcc tagaagtgtg ggaaattcag gaaaacgagt tgctccagtg     2460

aagcttcttg gggttgctag gacagagagc tcctttgaca caaaagacag gagcagggtc     2520

caggttcccc tgctgtgcag ggagggcagc cccgggcagt gggcataggg cagctcagtc     2580

cctggcctct tagcaccaca ttcctgtttt tcagcttatt tgaagtcctg cctcattctc     2640

actggagcct cagtctctcc tgcttggtct tggccctcaa ctggggcaag tgaagccaga     2700

ggagggtccc ccagctgggt gggctggaat ggaactcctc actagctgct ggggctccgc     2760

ccaccctgct cccttccgga caatgaagaa gcctttgcac cctgggagga aggaccaccc     2820

cgggccctct atgcctggcc agcctccagc tcctcagacc tcctgggtgg ggtttggctt     2880

cagggtgggg tttggaagct tctggaagtc gtgctggtct cccaggtgag gcaagccatg     2940

gttgctgggc tgtagggtga gtggcttgct tggtgggacc tgacgagttg gtggcatggg     3000

aaggatgtgg gtctctagtg ccttgccctg gcttagctgc aggagaagat ggctgctttc     3060

acttcccccc attgagctct gctccctctg agcctggtct tttgtccttt tttattttgg     3120

tctccaagat gaatgctcat ctttggaggg tgccaggtag aagctaggga ggggagtgtc     3180

ttctctctcc aggtttcacc ttccagtgtg cagaagttag aagggtctgg cgggggcagt     3240

gccttacaca tgcttgattc ccacgctacc ccctgccttg ggaggtgtgt ggaataaatt     3300

atttttgtta aggcaa                                                     3316


<210>  2
<211>  2583
<212>  DNA
<213>  Homo sapiens

<400>  2
ggaggcaggc ggtgccgcgg cgccgggacc cgactcatcc ggtgcttgcg tgtggtggtg       60

agcgcagcgc cgaggatgag gaggtgcaac agcggctccg ggccgccgcc gtcgctgctg      120

ctgctgctgc tgtggctgct cgcggttccc ggcgctaacg cggccccgcg gtcggcgctc      180

tattcgcctt ccgacccgct gacgctgctg caggcggaca cggtgcgcgg cgcggtgctg      240

ggctcccgca gcgcctgggc cgtggagttc ttcgcctcct ggtgcggcca ctgcatcgcc      300

ttcgccccga cgtggaaggc gctggccgaa gacgtcaaag cctggaggcc ggccctgtat      360

ctcgccgccc tggactgtgc tgaggagacc aacagtgcag tctgcagaga cttcaacatc      420

cctggcttcc cgactgtgag gttcttcaag gcctttacca agaacggctc gggagcagta      480

tttccagtgg ctggtgctga cgtgcagaca ctgcgggaga ggctcattga cgccctggag      540

tcccatcatg acacgtggcc cccagcctgt cccccactgg agcctgccaa gctggaggag      600

attgatggat tctttgcgag aaataacgaa gagtacctgg ctctgatctt tgaaaaggga      660

ggctcctacc tgggtagaga ggtggctctg gacctgtccc agcacaaagg cgtggcggtg      720

cgcagggtgc tgaacacaga ggccaatgtg gtgagaaagt ttggtgtcac cgacttcccc      780

tcttgctacc tgctgttccg gaatggctct gtctcccgag tccccgtgct catggaatcc      840

aggtccttct ataccgctta cctgcagaga ctctctgggc tcaccaggga ggctgcccag      900

accacagttg caccaaccac tgctaacaag atagctccca ctgtttggaa attggcagat      960

cgctccaaga tctacatggc tgacctggaa tctgcactgc actacatcct gcggatagaa     1020

gtgggcaggt tcccggtcct ggaagggcag cgcctggtgg ccctgaaaaa gtttgtggca     1080

gtgctggcca agtatttccc tggccggccc ttagtccaga acttcctgca ctccgtgaat     1140

gaatggctca agaggcagaa gagaaataaa attccctaca gtttctttaa aactgccctg     1200

gacgacagga aagagggtgc cgttcttgcc aagaaggtga actggattgg ctgccagggg     1260

agtgagccgc atttccgggg ctttccctgc tccctgtggg tcctcttcca cttcttgact     1320

gtgcaggcag ctcggcaaaa tgtagaccac tcacaggaag cagccaaggc caaggaggtc     1380

ctcccagcca tccgaggcta cgtgcactac ttcttcggct gccgagactg cgctagccac     1440

ttcgagcaga tggctgctgc ctccatgcac cgggtgggga gtcccaacgc cgctgtcctc     1500

tggctctggt ctagccacaa cagggtcaat gctcgccttg caggtgcccc cagcgaggac     1560

ccccagttcc ccaaggtgca gtggccaccc cgtgaacttt gttctgcctg ccacaatgaa     1620

cgcctggatg tgcccgtgtg ggacgtggaa gccaccctca acttcctcaa ggcccacttc     1680

tccccaagca acatcatcct ggacttccct gcagctgggt cagctgcccg gagggatgtg     1740

cagaatgtgg cagccgcccc agagctggcg atgggagccc tggagctgga aagccggaat     1800

tcaactctgg accctgggaa gcctgagatg atgaagtccc ccacaaacac caccccacat     1860

gtgccggctg agggacctga gcttatttga agtcctgcct cattctcact ggagcctcag     1920

tctctcctgc ttggtcttgg ccctcaactg gggcaagtga agccagagga gggtccccca     1980

gctgggtggg ctggaatgga actcctcact agctgctggg gctccgccca ccctgctccc     2040

ttccggacaa tgaagaagcc tttgcaccct gggaggaagg accaccccgg gccctctatg     2100

cctggccagc ctccagctcc tcagacctcc tgggtggggt ttggcttcag ggtggggttt     2160

ggaagcttct ggaagtcgtg ctggtctccc aggtgaggca agccatggtt gctgggctgt     2220

agggtgagtg gcttgcttgg tgggacctga cgagttggtg gcatgggaag gatgtgggtc     2280

tctagtgcct tgccctggct tagctgcagg agaagatggc tgctttcact tccccccatt     2340

gagctctgct ccctctgagc ctggtctttt gtcctttttt attttggtct ccaagatgaa     2400

tgctcatctt tggagggtgc caggtagaag ctagggaggg gagtgtcttc tctctccagg     2460

tttcaccttc cagtgtgcag aagttagaag ggtctggcgg gggcagtgcc ttacacatgc     2520

ttgattccca cgctaccccc tgccttggga ggtgtgtgga ataaattatt tttgttaagg     2580

caa                                                                   2583


<210>  3
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  4
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Leu Ile 
        595                 600                 


<210>  5
<211>  1576
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nucleic acid sequence of human QSOX (133-546)

<400>  5
atgggccatc atcaccacca tcaccatatg tcggcgctct attcgccttc cgacccgctg       60

acgctgctgc aggcggacac ggtgcgcggc gcggtgctgg gctcccgcag cgcctgggcc      120

gtggagttct tcgcctcctg gtgcggccac tgcatcgcct tcgccccgac gtggaaggcg      180

ctggccgaag acgtcaaagc ctggaggccg gccctgtatc tcgccgccct ggactgtgct      240

gaggagacca acagtgcagt ctgcagagac ttcaacatcc ctggcttccc gactgtgagg      300

ttcttcaagg cctttaccaa gaacggctca ggagcagtat ttccagtggc tggtgctgac      360

gtgcagacgc tgcgggagag gctcattgac gccctggagt cccatcatga cacgtggccc      420

ccagcctgtc ccccactgga gcctgccaag ctggaggaga ttgatggatt ctttgcgaga      480

aataacgaag agtacctggc tctgatcttt gaaaagggag gctcctacct ggctagagag      540

gtggctctgg acctgtccca gcacaaaggc gtggcggtgc gcagggtgct gaacacagag      600

gccaatgtgg tgagaaagtt tggtgtcacc gacttcccct cttgctacct gctgttccgg      660

aatggctctg tctcccgagt ccccgtgctc atggaatcca ggtccttcta taccgcttac      720

ctgcagagac tctctgggct aaccagggag gctgcccaga ccacagttgc accaaccact      780

gctaacaaga tagctcccac tgtttggaaa ttggcagatc gctccaagat ctacatggct      840

gacctggaat ctgcactgca ctacatcctg cggatagaag tgggcaggtt cccggtcctg      900

gaagggcagc gcctggtggc cctgaaaaag tttgtggcag tgctggccaa gtatttccct      960

ggccggccct tagtccagaa cttcctgcac tccgtgaatg aatggctcaa gaggcagaag     1020

agaaataaaa ttccctacag tttctttaaa actgccctgg acgacaggaa agagggtgcc     1080

gttctcgcca agaaggtgaa ctggattggc tgccagggga gtgagccgca tttccggggc     1140

tttccctgct ccctgtgggt tcttttccac ttcttgactg tgcaggcagc tcggcaaaat     1200

gtagaccact cacaggaagc agccaaggcc aaggaggtcc tcccagccat ccgaggctac     1260

gtgcactact tcttcggctg ccgagactgc gctagccact tcgagcagat ggctgctgcc     1320

tccatgcacc gggtggggag tcccaacgcc gctgtcctct ggctctggtc tagccacaac     1380

agggtcaatg ctcgccttgc aggtgccccc agcgaggacc cccagttccc caaggtgcag     1440

tggccacccc gtgaactttg ttctgcctgc cacaatgaac gcctggatgt gcccgtgtgg     1500

gacgtggaag ccaccctcaa cttcctcaag gcccacttct ccccaagcaa catcatcctg     1560

gacttccctg cataag                                                     1576


<210>  6
<211>  524
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence of human QSOX (133-546)

<400>  6

Met Gly His His His His His His His Met Ser Ala Leu Tyr Ser Pro 
1               5                   10                  15      


Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp Thr Val Arg Gly Ala Val 
            20                  25                  30          


Leu Gly Ser Arg Ser Ala Trp Ala Val Glu Phe Phe Ala Ser Trp Cys 
        35                  40                  45              


Gly His Cys Ile Ala Phe Ala Pro Thr Trp Lys Ala Leu Ala Glu Asp 
    50                  55                  60                  


Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu Ala Ala Leu Asp Cys Ala 
65                  70                  75                  80  


Glu Glu Thr Asn Ser Ala Val Cys Arg Asp Phe Asn Ile Pro Gly Phe 
                85                  90                  95      


Pro Thr Val Arg Phe Phe Lys Ala Phe Thr Lys Asn Gly Ser Gly Ala 
            100                 105                 110         


Val Phe Pro Val Ala Gly Ala Asp Val Gln Thr Leu Arg Glu Arg Leu 
        115                 120                 125             


Ile Asp Ala Leu Glu Ser His His Asp Thr Trp Pro Pro Ala Cys Pro 
    130                 135                 140                 


Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile Asp Gly Phe Phe Ala Arg 
145                 150                 155                 160 


Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe Glu Lys Gly Gly Ser Tyr 
                165                 170                 175     


Leu Ala Arg Glu Val Ala Leu Asp Leu Ser Gln His Lys Gly Val Ala 
            180                 185                 190         


Val Arg Arg Val Leu Asn Thr Glu Ala Asn Val Val Arg Lys Phe Gly 
        195                 200                 205             


Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu Phe Arg Asn Gly Ser Val 
    210                 215                 220                 


Ser Arg Val Pro Val Leu Met Glu Ser Arg Ser Phe Tyr Thr Ala Tyr 
225                 230                 235                 240 


Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu Ala Ala Gln Thr Thr Val 
                245                 250                 255     


Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro Thr Val Trp Lys Leu Ala 
            260                 265                 270         


Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu Glu Ser Ala Leu His Tyr 
        275                 280                 285             


Ile Leu Arg Ile Glu Val Gly Arg Phe Pro Val Leu Glu Gly Gln Arg 
    290                 295                 300                 


Leu Val Ala Leu Lys Lys Phe Val Ala Val Leu Ala Lys Tyr Phe Pro 
305                 310                 315                 320 


Gly Arg Pro Leu Val Gln Asn Phe Leu His Ser Val Asn Glu Trp Leu 
                325                 330                 335     


Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr Ser Phe Phe Lys Thr Ala 
            340                 345                 350         


Leu Asp Asp Arg Lys Glu Gly Ala Val Leu Ala Lys Lys Val Asn Trp 
        355                 360                 365             


Ile Gly Cys Gln Gly Ser Glu Pro His Phe Arg Gly Phe Pro Cys Ser 
    370                 375                 380                 


Leu Trp Val Leu Phe His Phe Leu Thr Val Gln Ala Ala Arg Gln Asn 
385                 390                 395                 400 


Val Asp His Ser Gln Glu Ala Ala Lys Ala Lys Glu Val Leu Pro Ala 
                405                 410                 415     


Ile Arg Gly Tyr Val His Tyr Phe Phe Gly Cys Arg Asp Cys Ala Ser 
            420                 425                 430         


His Phe Glu Gln Met Ala Ala Ala Ser Met His Arg Val Gly Ser Pro 
        435                 440                 445             


Asn Ala Ala Val Leu Trp Leu Trp Ser Ser His Asn Arg Val Asn Ala 
    450                 455                 460                 


Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro Gln Phe Pro Lys Val Gln 
465                 470                 475                 480 


Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys His Asn Glu Arg Leu Asp 
                485                 490                 495     


Val Pro Val Trp Asp Val Glu Ala Thr Leu Asn Phe Leu Lys Ala His 
            500                 505                 510         


Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe Pro Ala 
        515                 520                 


<210>  7
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 variable light amino acid sequence

<400>  7

Asp Val Val Met Thr Gln Thr His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  8
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 variable heavy amino acid sequence

<400>  8

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Asp Gly Arg Thr Asp Tyr Lys Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Phe Cys Ala 
                85                  90                  95      


Ser Asp Tyr Tyr Gly Ser Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  9
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  9

Asp Val Val Met Thr Gln Thr His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg 
        


<210>  10
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  10

Asp Val Val Met Thr Gln Thr His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Thr Ile Cys Lys 
            20                  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  11

Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  12

Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys 
1               5                   10                  15  


<210>  13
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  13

Leu Leu Ile His Ser Ala Ser Tyr Arg 
1               5                   


<210>  14
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  14

Asp Val Val Met Thr Gln Thr His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


<210>  15
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  15

Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
1               5                   10                  15      


Gln 
    


<210>  16
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  16

Gln Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile His Ser Ala Ser 
1               5                   10                  15      


Tyr 
    


<210>  17
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  17

Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe 
1               5                   10      


<210>  18
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  18

Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
1               5                   10          


<210>  19
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  19

Ser Leu Thr Gly Tyr Gly Val Asn Trp 
1               5                   


<210>  20
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  20

Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
1               5                   10                  15  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  21

Asp Tyr Lys Ser Ala Leu Lys Ser Arg Leu 
1               5                   10  


<210>  22
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  22

Lys Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe 
1               5                   10                  15      


<210>  23
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  23

Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp 
1               5                   10                  15      


Gly Arg 
        


<210>  24
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  24

Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg 
1               5                   10              


<210>  25
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  25

Gly Leu Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Thr Asp Tyr 
1               5                   10                  15      


Lys 
    


<210>  26
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 representative peptide detected by LC-MS/MS

<400>  26

Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg 
1               5                   10      


<210>  27
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 light chain amino acid sequence

<400>  27

Asp Val Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  28
<211>  484
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 heavy chain amino acid sequence

<400>  28

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Asp Gly Arg Thr Asp Tyr Lys Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Phe Cys Ala 
                85                  90                  95      


Ser Asp Tyr Tyr Gly Ser Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Glu 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
    210                 215                 220                 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            260                 265                 270         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
305                 310                 315                 320 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
            340                 345                 350         


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
        355                 360                 365             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe 
385                 390                 395                 400 


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                405                 410                 415     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Glu Lys Ser Leu Ser His Ser Pro Gly Lys Gln Leu Asp Glu Thr Cys 
        435                 440                 445             


Ala Glu Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr 
    450                 455                 460                 


Ile Phe Ile Ser Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Ala Val 
465                 470                 475                 480 


Thr Leu Phe Lys 
                


<210>  29
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 light chain CDR1 amino acid sequence

<400>  29

Gln Asp Val Ser Thr Ala 
1               5       


<210>  30
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 light chain CDR2 amino acid sequence

<400>  30

Ser Ala Ser 
1           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 light chain CDR3 amino acid sequence

<400>  31

Gln Gln His Tyr Ser Ile Pro Leu Thr 
1               5                   


<210>  32
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 heavy chain CDR1 amino acid sequence

<400>  32

Gly Phe Ser Leu Thr Gly Tyr Gly 
1               5               


<210>  33
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 heavy chain CDR2 amino acid sequence

<400>  33

Ile Trp Gly Asp Gly Arg Thr 
1               5           


<210>  34
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAb492.1 heavy chain CDR3 amino acid sequence

<400>  34

Ala Ser Asp Tyr Tyr Gly Ser Gly Ser Phe Ala Tyr 
1               5                   10          


<210>  35
<211>  747
<212>  PRT
<213>  Artificial sequence

<220>
<223>  QSOX1 trypsin cleavage product (Lower band)

<400>  35

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  36
<211>  747
<212>  PRT
<213>  Artificial sequence

<220>
<223>  QSOX1 chemotrypsin cleavage product (Lower band)

<400>  36

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  37
<211>  747
<212>  PRT
<213>  Artificial sequence

<220>
<223>  QSOX1 trypsin cleavage product (Upper band)

<400>  37

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  38
<211>  747
<212>  PRT
<213>  Artificial sequence

<220>
<223>  QSOX1 chemotrypsin cleavage product (Upper band)

<400>  38

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  39
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  39
ggtcagtaca tatgtcggcg ctctattcgc cttccg                                 36


<210>  40
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  40
tatgtggatc cttatgcagg gaagtccagg atgatgtt                               38


<210>  41
<211>  613
<212>  PRT
<213>  Cavia porcellus

<400>  41

Met Thr Gly Cys Gly Arg Arg Ser Gly Trp Leu Pro Pro Leu Arg Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Leu Gly Gly Pro Gly Val Gly Ala Ala Gln 
            20                  25                  30          


Leu Ala Ala Leu Tyr Ser Ala Ser Asp Pro Leu Thr Leu Leu Gln Ala 
        35                  40                  45              


Asp Thr Val Arg Ser Thr Val Leu Asn Ser Pro Ser Ala Trp Ala Val 
    50                  55                  60                  


Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr 
65                  70                  75                  80  


Trp Lys Ala Leu Ala Lys Asp Ile Lys Asp Trp Arg Pro Ala Leu Asn 
                85                  90                  95      


Leu Ala Ala Leu Asn Cys Ala Asp Glu Thr Asn Asn Ala Val Cys Arg 
            100                 105                 110         


Asp Phe Asn Ile Ala Gly Phe Pro Ser Val Arg Phe Phe Lys Ala Phe 
        115                 120                 125             


Ser Lys Asn Ser Thr Gly Thr Thr Leu Pro Val Ala Gly Ala Asn Val 
    130                 135                 140                 


Gln Met Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp 
145                 150                 155                 160 


Thr Trp Pro Ser Ala Cys Pro Pro Leu Glu Pro Val Lys Pro Lys Glu 
                165                 170                 175     


Ile Asp Thr Phe Phe Ala Arg Asn Asn Gln Glu Tyr Leu Val Leu Ile 
            180                 185                 190         


Phe Glu Gln Glu Asn Ser Tyr Leu Gly Arg Glu Val Thr Leu Asp Leu 
        195                 200                 205             


Ser Gln His His Asp Leu Val Val Arg Arg Val Leu Ser Thr Glu Ala 
    210                 215                 220                 


Asn Val Val Arg Lys Phe Gly Val Ala Asp Phe Pro Ser Cys Tyr Leu 
225                 230                 235                 240 


Leu Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Val Glu Ser 
                245                 250                 255     


Arg Arg Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Glu Val Thr Arg 
            260                 265                 270         


Glu Gly Thr Pro Thr Pro Ala Val Pro Thr Ile Ser Asp Gln Ile Ala 
        275                 280                 285             


Pro Thr Val Trp Lys Phe Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp 
    290                 295                 300                 


Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Val Glu Val Gly Arg Phe 
305                 310                 315                 320 


Ser Val Leu Glu Gly Gln Arg Leu Met Ala Leu Lys Lys Phe Val Thr 
                325                 330                 335     


Val Leu Thr Lys Tyr Phe Pro Gly Gln Pro Leu Val Arg Asn Phe Leu 
            340                 345                 350         


Gln Ser Thr Asn Glu Trp Leu Lys Arg Gln His Lys Lys Lys Met Pro 
        355                 360                 365             


Tyr Ser Phe Phe Lys Thr Ala Met Asp Ser Arg Asn Glu Glu Ala Val 
    370                 375                 380                 


Ile Thr Lys Glu Val Asn Trp Val Gly Cys Gln Gly Ser Glu Ser His 
385                 390                 395                 400 


Phe Arg Gly Phe Pro Cys Ser Leu Trp Ile Leu Phe His Phe Leu Thr 
                405                 410                 415     


Val Gln Ala Ser Gln Lys Asn Ala Glu Ser Ser Gln Lys Pro Ala Asn 
            420                 425                 430         


Gly Gln Glu Val Leu Gln Ala Ile Arg Asn Tyr Val Arg Phe Phe Phe 
        435                 440                 445             


Gly Cys Arg Asp Cys Ala Asn His Phe Glu Gln Met Ala Ala Gly Ser 
    450                 455                 460                 


Met His Arg Val Lys Ser Pro Asn Asp Ala Val Leu Trp Leu Trp Thr 
465                 470                 475                 480 


Ser His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp 
                485                 490                 495     


Pro Gln Phe Pro Lys Val Gln Trp Pro Pro Pro Glu Leu Cys Ser Ala 
            500                 505                 510         


Cys His Asn Glu Leu Ser Gly Glu Pro Val Trp Asp Val Asp Ala Thr 
        515                 520                 525             


Leu Arg Phe Leu Lys Thr His Phe Ser Pro Ser Asn Ile Val Leu Asn 
    530                 535                 540                 


Phe Pro Pro Ala Glu Pro Ala Ser Arg Ser Ser Val His Ser Trp Gly 
545                 550                 555                 560 


Ala Thr Pro His Leu Glu Leu Asp Ala Leu Gly Leu Val Thr Arg Asn 
                565                 570                 575     


Ser Ala Leu Ala Leu Glu Arg Ala Glu Ile Ser Glu Ser Pro Gly Ser 
            580                 585                 590         


Asn Ala Met Pro Asn Ile Pro Ala Glu Arg Pro Glu Leu Phe Glu Ala 
        595                 600                 605             


Leu Ser His Ser Arg 
    610             


<210>  42
<211>  750
<212>  PRT
<213>  Rattus norvegicus

<400>  42

Met Arg Arg Cys Gly Arg His Ser Gly Pro Pro Ser Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Leu Leu Leu Ser Val Pro Gly Ala Tyr Ala 
            20                  25                  30          


Ala Arg Leu Ser Val Leu Tyr Ser Ser Ser Asp Pro Leu Thr Leu Leu 
        35                  40                  45              


Asp Ala Asp Thr Val Arg Pro Ala Val Leu Gly Ser Ser Ser Ala Trp 
    50                  55                  60                  


Ala Val Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala 
65                  70                  75                  80  


Pro Thr Trp Lys Glu Leu Ala Asn Asp Val Lys Asp Trp Arg Pro Ala 
                85                  90                  95      


Leu Asn Leu Ala Val Leu Asp Cys Ala Asp Glu Thr Asn Ser Ala Val 
            100                 105                 110         


Cys Arg Glu Phe Asn Ile Ala Gly Phe Pro Thr Val Arg Phe Phe Lys 
        115                 120                 125             


Ala Phe Ser Lys Asn Gly Thr Gly Thr Ala Leu Pro Ala Ala Gly Ala 
    130                 135                 140                 


Asn Val Gln Thr Leu Arg Met Arg Leu Ile Asp Ala Leu Glu Ser His 
145                 150                 155                 160 


Arg Asp Thr Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu 
                165                 170                 175     


Lys Asp Ile Asn Glu Phe Phe Thr Arg Ser Lys Ala Glu Tyr Leu Ala 
            180                 185                 190         


Leu Ile Phe Glu Arg Glu Asp Ser Tyr Leu Gly Arg Glu Val Thr Leu 
        195                 200                 205             


Asp Leu Ser Gln Phe His Ala Val Ala Val Arg Arg Val Leu Asn Ser 
    210                 215                 220                 


Glu Ser Asp Val Val Ser Lys Phe Ala Val Thr Asp Phe Pro Ser Cys 
225                 230                 235                 240 


Tyr Leu Leu Leu Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Val 
                245                 250                 255     


Glu Ser Arg Pro Phe Tyr Thr Ser Tyr Leu Arg Gly Leu Pro Gly Leu 
            260                 265                 270         


Thr Arg Glu Ala Pro Pro Thr Thr Ala Ala Pro Val Thr Pro Asp Lys 
        275                 280                 285             


Ile Ala Pro Thr Val Trp Lys Phe Ala Asp Arg Ser Lys Ile Tyr Met 
    290                 295                 300                 


Ala Asp Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Val Glu Val Gly 
305                 310                 315                 320 


Lys Phe Ser Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe 
                325                 330                 335     


Val Ala Val Leu Ala Lys Tyr Phe Pro Gly Gln Pro Leu Val Gln Asn 
            340                 345                 350         


Phe Leu His Ser Ile Asn Asp Trp Leu Gln Lys Gln Gln Lys Lys Lys 
        355                 360                 365             


Ile Pro Tyr Ser Tyr Phe Lys Ala Ala Leu Asp Ser Arg Lys Glu Asn 
    370                 375                 380                 


Ala Val Leu Ala Glu Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu 
385                 390                 395                 400 


Pro His Phe Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe 
                405                 410                 415     


Leu Thr Val Gln Ala His Arg Tyr Ser Glu Ala His Pro Gln Glu Pro 
            420                 425                 430         


Ala Asp Gly Gln Glu Val Leu Gln Ala Met Arg Ser Tyr Val Gln Ser 
        435                 440                 445             


Phe Phe Gly Cys Arg Asp Cys Ala Asn His Phe Glu Gln Met Ala Ala 
    450                 455                 460                 


Ala Ser Met His Gln Val Lys Ser Pro Ser Asn Ala Val Leu Trp Leu 
465                 470                 475                 480 


Trp Thr Ser His Asn Arg Val Asn Ala Arg Leu Ser Gly Ala Leu Ser 
                485                 490                 495     


Glu Asp Pro Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys 
            500                 505                 510         


Ser Ala Cys His Asn Glu Val Asn Gly Gln Val Pro Leu Trp Asp Leu 
        515                 520                 525             


Gly Ala Thr Leu Asn Phe Leu Lys Ala His Phe Ser Pro Ala Asn Ile 
    530                 535                 540                 


Val Arg Asp Pro Pro Ala Pro Gly Pro Ala Ser Arg Arg Gly Thr Gln 
545                 550                 555                 560 


Asp Pro Glu Ala Ser Pro Asn Leu Val Met Asp Thr Leu Lys Leu Glu 
                565                 570                 575     


Thr Gly Asn Ser Val Leu Gly His Glu Gln Ala Ala Ser Ala Ala Ser 
            580                 585                 590         


Pro Gly Ala Thr Ala Leu Asp Val Pro Ala Gly Lys Pro Glu Ala Ser 
        595                 600                 605             


Gly Pro Gln Glu Leu Asn Ala Gly Leu Ser Met Gly Gly Ala Ser Pro 
    610                 615                 620                 


Gly Gln Gly Pro Pro Glu His Thr Glu Glu Leu Leu Arg Asp Val Gln 
625                 630                 635                 640 


Glu Asn Ala Gln Gly Gln Gln His Leu Ser Lys Arg Asp Thr Glu Ala 
                645                 650                 655     


Leu Leu Leu Pro Glu Val Asn His Leu Gln Gly Pro Leu Ala Pro Arg 
            660                 665                 670         


Arg Gly Gly His Ser Pro Lys Gln Leu Ala Ser Ile Leu Glu Gly Glu 
        675                 680                 685             


Pro Glu Ala Leu Ala Ile Gln Gly Arg Arg Gln Trp Leu Gln Val Leu 
    690                 695                 700                 


Gly Gly Gly Val Ser Phe Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr 
705                 710                 715                 720 


Ser Val Ser Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Arg Ala 
                725                 730                 735     


Arg Met Arg Thr Pro Lys Gly His Val Ser Tyr Pro Thr Ala 
            740                 745                 750 


<210>  43
<211>  748
<212>  PRT
<213>  Mus musculus

<400>  43

Met Arg Arg Cys Gly Arg Leu Ser Gly Pro Pro Ser Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Pro Leu Leu Phe Ser Gly Pro Gly Ala Tyr Ala 
            20                  25                  30          


Ala Arg Leu Ser Val Leu Tyr Ser Ser Ser Asp Pro Leu Thr Leu Leu 
        35                  40                  45              


Asp Ala Asp Ser Val Arg Pro Thr Val Leu Gly Ser Ser Ser Ala Trp 
    50                  55                  60                  


Ala Val Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala 
65                  70                  75                  80  


Pro Thr Trp Lys Glu Leu Ala Asn Asp Val Lys Asp Trp Arg Pro Ala 
                85                  90                  95      


Leu Asn Leu Ala Val Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val 
            100                 105                 110         


Cys Arg Glu Phe Asn Ile Ala Gly Phe Pro Thr Val Arg Phe Phe Gln 
        115                 120                 125             


Ala Phe Thr Lys Asn Gly Ser Gly Ala Thr Leu Pro Gly Ala Gly Ala 
    130                 135                 140                 


Asn Val Gln Thr Leu Arg Met Arg Leu Ile Asp Ala Leu Glu Ser His 
145                 150                 155                 160 


Arg Asp Thr Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu 
                165                 170                 175     


Asn Asp Ile Asp Gly Phe Phe Thr Arg Asn Lys Ala Asp Tyr Leu Ala 
            180                 185                 190         


Leu Val Phe Glu Arg Glu Asp Ser Tyr Leu Gly Arg Glu Val Thr Leu 
        195                 200                 205             


Asp Leu Ser Gln Tyr His Ala Val Ala Val Arg Arg Val Leu Asn Thr 
    210                 215                 220                 


Glu Ser Asp Leu Val Asn Lys Phe Gly Val Thr Asp Phe Pro Ser Cys 
225                 230                 235                 240 


Tyr Leu Leu Leu Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Val 
                245                 250                 255     


Glu Ser Arg Ser Phe Tyr Thr Ser Tyr Leu Arg Gly Leu Pro Gly Leu 
            260                 265                 270         


Thr Arg Asp Ala Pro Pro Thr Thr Ala Thr Pro Val Thr Ala Asp Lys 
        275                 280                 285             


Ile Ala Pro Thr Val Trp Lys Phe Ala Asp Arg Ser Lys Ile Tyr Met 
    290                 295                 300                 


Ala Asp Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Val Glu Val Gly 
305                 310                 315                 320 


Lys Phe Ser Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe 
                325                 330                 335     


Val Ala Val Leu Ala Lys Tyr Phe Pro Gly Gln Pro Leu Val Gln Asn 
            340                 345                 350         


Phe Leu His Ser Ile Asn Asp Trp Leu Gln Lys Gln Gln Lys Lys Arg 
        355                 360                 365             


Ile Pro Tyr Ser Phe Phe Lys Ala Ala Leu Asp Ser Arg Lys Glu Asp 
    370                 375                 380                 


Ala Val Leu Thr Glu Lys Val Asn Trp Val Gly Cys Gln Gly Ser Glu 
385                 390                 395                 400 


Pro His Phe Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe 
                405                 410                 415     


Leu Thr Val Gln Ala Asn Arg Tyr Ser Glu Ala His Pro Gln Glu Pro 
            420                 425                 430         


Ala Asp Gly Gln Glu Val Leu Gln Ala Met Arg Ser Tyr Val Gln Phe 
        435                 440                 445             


Phe Phe Gly Cys Arg Asp Cys Ala Asp His Phe Glu Gln Met Ala Ala 
    450                 455                 460                 


Ala Ser Met His Gln Val Arg Ser Pro Ser Asn Ala Ile Leu Trp Leu 
465                 470                 475                 480 


Trp Thr Ser His Asn Arg Val Asn Ala Arg Leu Ser Gly Ala Leu Ser 
                485                 490                 495     


Glu Asp Pro His Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys 
            500                 505                 510         


Ser Ala Cys His Asn Glu Leu Asn Gly Gln Val Pro Leu Trp Asp Leu 
        515                 520                 525             


Gly Ala Thr Leu Asn Phe Leu Lys Ala His Phe Ser Pro Ala Asn Ile 
    530                 535                 540                 


Val Ile Asp Ser Ser Ala Ser Arg His Thr Gly Arg Arg Gly Ser Pro 
545                 550                 555                 560 


Glu Ala Thr Pro Glu Leu Val Met Asp Thr Leu Lys Leu Glu Ser Arg 
                565                 570                 575     


Asn Ser Val Leu Gly His Glu Gln Ala Ala Ser Ala Glu Ser Pro Gly 
            580                 585                 590         


Ala Thr Ala Leu Asp Val Pro Ala Glu Lys Pro Glu Ala Ser Gly Pro 
        595                 600                 605             


Gln Glu Leu Tyr Thr Gly Leu Arg Met Gly Gly Ala Ser Pro Gly Gln 
    610                 615                 620                 


Gly Pro Pro Glu Arg Met Glu Asp His Gln Arg Asp Met Gln Glu Asn 
625                 630                 635                 640 


Ala Pro Gly Gln Gln His Leu Ser Lys Arg Asp Thr Glu Ala Leu Phe 
                645                 650                 655     


Leu Pro Glu Val Asn His Leu Gln Gly Pro Leu Glu Leu Arg Arg Gly 
            660                 665                 670         


Gly Arg Ser Pro Lys Gln Leu Ala Pro Ile Leu Glu Glu Glu Pro Glu 
        675                 680                 685             


Ala Leu Ala Ile Gln Gly Gln Gly Gln Trp Leu Gln Val Leu Gly Gly 
    690                 695                 700                 


Gly Ile Ser His Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Val 
705                 710                 715                 720 


Ser Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Arg Ala Arg Leu 
                725                 730                 735     


Arg Thr Pro Lys Gly His Ala Ser Tyr Pro Thr Ala 
            740                 745             


