                         SEQUENCE LISTING

<110>  University College London (UCLB)
 
<120>  Treatment of disease

<130>  AXH/65754PCT1

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1389
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctgctgc tggcgagatg tctgctgcta gtcctcgtct cctcgctgct ggtatgctcg       60

ggactggcgt gcggaccggg cagggggttc gggaagagga ggcaccccaa aaagctgacc      120

cctttagcct acaagcagtt tatccccaat gtggccgaga agaccctagg cgccagcgga      180

aggtatgaag ggaagatctc cagaaactcc gagcgattta aggaactcac ccccaattac      240

aaccccgaca tcatatttaa ggatgaagaa aacaccggag cggacaggct gatgactcag      300

aggtgtaagg acaagttgaa cgctttggcc atctcggtga tgaaccagtg gccaggagtg      360

aaactgcggg tgaccgaggg ctgggacgaa gatggccacc actcagagga gtctctgcac      420

tacgagggcc gcgcagtgga catcaccacg tctgaccgcg accgcagcaa gtacggcatg      480

ctggcccgcc tggcggtgga ggccggcttc gactgggtgt actacgagtc caaggcacat      540

atccactgct cggtgaaagc agagaactcg gtggcggcca aatcgggagg ctgcttcccg      600

ggctcggcca cggtgcacct ggagcagggc ggcaccaagc tggtgaagga cctgagcccc      660

ggggaccgcg tgctggcggc ggacgaccag ggccggctgc tctacagcga cttcctcact      720

ttcctggacc gcgacgacgg cgccaagaag gtcttctacg tgatcgagac gcgggagccg      780

cgcgagcgcc tgctgctcac cgccgcgcac ctgctctttg tggcgccgca caacgactcg      840

gccaccgggg agcccgaggc gtcctcgggc tcggggccgc cttccggggg cgcactgggg      900

cctcgggcgc tgttcgccag ccgcgtgcgc ccgggccagc gcgtgtacgt ggtggccgag      960

cgtgacgggg accgccggct cctgcccgcc gctgtgcaca gcgtgaccct aagcgaggag     1020

gccgcgggcg cctacgcgcc gctcacggcc cagggcacca ttctcatcaa ccgggtgctg     1080

gcctcgtgct acgcggtcat cgaggagcac agctgggcgc accgggcctt cgcgcccttc     1140

cgcctggcgc acgcgctcct ggctgcactg gcgcccgcgc gcacggaccg cggcggggac     1200

agcggcggcg gggaccgcgg gggcggcggc ggcagagtag ccctaaccgc tccaggtgct     1260

gccgacgctc cgggtgcggg ggccaccgcg ggcatccact ggtactcgca gctgctctac     1320

caaataggca cctggctcct ggacagcgag gccctgcacc cgctgggcat ggcggtcaag     1380

tccagctga                                                             1389


<210>  2
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Gly Pro Gly Arg Gly Phe Gly Lys 
            20                  25                  30          


Arg Arg His Pro Lys Lys Leu Thr Pro Leu Ala Tyr Lys Gln Phe Ile 
        35                  40                  45              


Pro Asn Val Ala Glu Lys Thr Leu Gly Ala Ser Gly Arg Tyr Glu Gly 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ser Glu Arg Phe Lys Glu Leu Thr Pro Asn Tyr 
65                  70                  75                  80  


Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Thr Gly Ala Asp Arg 
                85                  90                  95      


Leu Met Thr Gln Arg Cys Lys Asp Lys Leu Asn Ala Leu Ala Ile Ser 
            100                 105                 110         


Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg Val Thr Glu Gly Trp 
        115                 120                 125             


Asp Glu Asp Gly His His Ser Glu Glu Ser Leu His Tyr Glu Gly Arg 
    130                 135                 140                 


Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg Ser Lys Tyr Gly Met 
145                 150                 155                 160 


Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr Glu 
                165                 170                 175     


Ser Lys Ala His Ile His Cys Ser Val Lys Ala Glu Asn Ser Val Ala 
            180                 185                 190         


Ala Lys Ser Gly Gly Cys Phe Pro Gly Ser Ala Thr Val His Leu Glu 
        195                 200                 205             


Gln Gly Gly Thr Lys Leu Val Lys Asp Leu Ser Pro Gly Asp Arg Val 
    210                 215                 220                 


Leu Ala Ala Asp Asp Gln Gly Arg Leu Leu Tyr Ser Asp Phe Leu Thr 
225                 230                 235                 240 


Phe Leu Asp Arg Asp Asp Gly Ala Lys Lys Val Phe Tyr Val Ile Glu 
                245                 250                 255     


Thr Arg Glu Pro Arg Glu Arg Leu Leu Leu Thr Ala Ala His Leu Leu 
            260                 265                 270         


Phe Val Ala Pro His Asn Asp Ser Ala Thr Gly Glu Pro Glu Ala Ser 
        275                 280                 285             


Ser Gly Ser Gly Pro Pro Ser Gly Gly Ala Leu Gly Pro Arg Ala Leu 
    290                 295                 300                 


Phe Ala Ser Arg Val Arg Pro Gly Gln Arg Val Tyr Val Val Ala Glu 
305                 310                 315                 320 


Arg Asp Gly Asp Arg Arg Leu Leu Pro Ala Ala Val His Ser Val Thr 
                325                 330                 335     


Leu Ser Glu Glu Ala Ala Gly Ala Tyr Ala Pro Leu Thr Ala Gln Gly 
            340                 345                 350         


Thr Ile Leu Ile Asn Arg Val Leu Ala Ser Cys Tyr Ala Val Ile Glu 
        355                 360                 365             


Glu His Ser Trp Ala His Arg Ala Phe Ala Pro Phe Arg Leu Ala His 
    370                 375                 380                 


Ala Leu Leu Ala Ala Leu Ala Pro Ala Arg Thr Asp Arg Gly Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Gly Asp Arg Gly Gly Gly Gly Gly Arg Val Ala Leu Thr 
                405                 410                 415     


Ala Pro Gly Ala Ala Asp Ala Pro Gly Ala Gly Ala Thr Ala Gly Ile 
            420                 425                 430         


His Trp Tyr Ser Gln Leu Leu Tyr Gln Ile Gly Thr Trp Leu Leu Asp 
        435                 440                 445             


Ser Glu Ala Leu His Pro Leu Gly Met Ala Val Lys Ser Ser 
    450                 455                 460         


<210>  3
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtctcccg cccggctccg gccccgactg cacttctgcc tggtcctgtt gctgctgctg       60

gtggtgccgg cggcatgggg ctgcgggccg ggtcgggtgg tgggcagccg ccggcgaccg      120

ccacgcaaac tcgtgccgct cgcctacaag cagttcagcc ccaatgtgcc cgagaagacc      180

ctgggcgcca gcggacgcta tgaaggcaag atcgctcgca gctccgagcg cttcaaggag      240

ctcaccccca attacaatcc agacatcatc ttcaaggacg aggagaacac aggcgccgac      300

cgcctcatga cccagcgctg caaggaccgc ctgaactcgc tggctatctc ggtgatgaac      360

cagtggcccg gtgtgaagct gcgggtgacc gagggctggg acgaggacgg ccaccactca      420

gaggagtccc tgcattatga gggccgcgcg gtggacatca ccacatcaga ccgcgaccgc      480

aataagtatg gactgctggc gcgcttggca gtggaggccg gctttgactg ggtgtattac      540

gagtcaaagg cccacgtgca ttgctccgtc aagtccgagc actcggccgc agccaagacg      600

ggcggctgct tccctgccgg agcccaggta cgcctggaga gtggggcgcg tgtggccttg      660

tcagccgtga ggccgggaga ccgtgtgctg gccatggggg aggatgggag ccccaccttc      720

agcgatgtgc tcattttcct ggaccgcgag cctcacaggc tgagagcctt ccaggtcatc      780

gagactcagg accccccacg ccgcctggca ctcacacccg ctcacctgct ctttacggct      840

gacaatcaca cggagccggc agcccgcttc cgggccacat ttgccagcca cgtgcagcct      900

ggccagtacg tgctggtggc tggggtgcca ggcctgcagc ctgcccgcgt ggcagctgtc      960

tctacacacg tggccctcgg ggcctacgcc ccgctcacaa agcatgggac actggtggtg     1020

gaggatgtgg tggcatcctg cttcgcggcc gtggctgacc accacctggc tcagttggcc     1080

ttctggcccc tgagactctt tcacagcttg gcatggggca gctggactcc gggggagggt     1140

gtgcattggt acccccagct gctctaccgc ctggggcgtc tcctgctaga agagggcagc     1200

ttccacccac tgggcatgtc cggggcaggg agctga                               1236


<210>  4
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Pro Ala Arg Leu Arg Pro Arg Leu His Phe Cys Leu Val Leu 
1               5                   10                  15      


Leu Leu Leu Leu Val Val Pro Ala Ala Trp Gly Cys Gly Pro Gly Arg 
            20                  25                  30          


Val Val Gly Ser Arg Arg Arg Pro Pro Arg Lys Leu Val Pro Leu Ala 
        35                  40                  45              


Tyr Lys Gln Phe Ser Pro Asn Val Pro Glu Lys Thr Leu Gly Ala Ser 
    50                  55                  60                  


Gly Arg Tyr Glu Gly Lys Ile Ala Arg Ser Ser Glu Arg Phe Lys Glu 
65                  70                  75                  80  


Leu Thr Pro Asn Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn 
                85                  90                  95      


Thr Gly Ala Asp Arg Leu Met Thr Gln Arg Cys Lys Asp Arg Leu Asn 
            100                 105                 110         


Ser Leu Ala Ile Ser Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg 
        115                 120                 125             


Val Thr Glu Gly Trp Asp Glu Asp Gly His His Ser Glu Glu Ser Leu 
    130                 135                 140                 


His Tyr Glu Gly Arg Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg 
145                 150                 155                 160 


Asn Lys Tyr Gly Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp 
                165                 170                 175     


Trp Val Tyr Tyr Glu Ser Lys Ala His Val His Cys Ser Val Lys Ser 
            180                 185                 190         


Glu His Ser Ala Ala Ala Lys Thr Gly Gly Cys Phe Pro Ala Gly Ala 
        195                 200                 205             


Gln Val Arg Leu Glu Ser Gly Ala Arg Val Ala Leu Ser Ala Val Arg 
    210                 215                 220                 


Pro Gly Asp Arg Val Leu Ala Met Gly Glu Asp Gly Ser Pro Thr Phe 
225                 230                 235                 240 


Ser Asp Val Leu Ile Phe Leu Asp Arg Glu Pro His Arg Leu Arg Ala 
                245                 250                 255     


Phe Gln Val Ile Glu Thr Gln Asp Pro Pro Arg Arg Leu Ala Leu Thr 
            260                 265                 270         


Pro Ala His Leu Leu Phe Thr Ala Asp Asn His Thr Glu Pro Ala Ala 
        275                 280                 285             


Arg Phe Arg Ala Thr Phe Ala Ser His Val Gln Pro Gly Gln Tyr Val 
    290                 295                 300                 


Leu Val Ala Gly Val Pro Gly Leu Gln Pro Ala Arg Val Ala Ala Val 
305                 310                 315                 320 


Ser Thr His Val Ala Leu Gly Ala Tyr Ala Pro Leu Thr Lys His Gly 
                325                 330                 335     


Thr Leu Val Val Glu Asp Val Val Ala Ser Cys Phe Ala Ala Val Ala 
            340                 345                 350         


Asp His His Leu Ala Gln Leu Ala Phe Trp Pro Leu Arg Leu Phe His 
        355                 360                 365             


Ser Leu Ala Trp Gly Ser Trp Thr Pro Gly Glu Gly Val His Trp Tyr 
    370                 375                 380                 


Pro Gln Leu Leu Tyr Arg Leu Gly Arg Leu Leu Leu Glu Glu Gly Ser 
385                 390                 395                 400 


Phe His Pro Leu Gly Met Ser Gly Ala Gly Ser 
                405                 410     


<210>  5
<211>  1191
<212>  DNA
<213>  Homo sapiens

<400>  5
atggctctcc tgaccaatct actgcccctg tgctgcttgg cacttctggc gctgccagcc       60

cagagctgcg ggccgggccg ggggccggtt ggccggcgcc gctatgcgcg caagcagctc      120

gtgccgctac tctacaagca atttgtgccc ggcgtgccag agcggaccct gggcgccagt      180

gggccagcgg aggggagggt ggcaaggggc tccgagcgct tccgggacct cgtgcccaac      240

tacaaccccg acatcatctt caaggatgag gagaacagtg gagccgaccg cctgatgacc      300

gagcgttgta aggagcgggt gaacgctttg gccattgccg tgatgaacat gtggcccgga      360

gtgcgcctac gagtgactga gggctgggac gaggacggcc accacgctca ggattcactc      420

cactacgaag gccgtgcttt ggacatcact acgtctgacc gcgaccgcaa caagtatggg      480

ttgctggcgc gcctcgcagt ggaagccggc ttcgactggg tctactacga gtcccgcaac      540

cacgtccacg tgtcggtcaa agctgataac tcactggcgg tccgggcggg cggctgcttt      600

ccgggaaatg caactgtgcg cctgtggagc ggcgagcgga aagggctgcg ggaactgcac      660

cgcggagact gggttttggc ggccgatgcg tcaggccggg tggtgcccac gccggtgctg      720

ctcttcctgg accgggactt gcagcgccgg gcttcatttg tggctgtgga gaccgagtgg      780

cctccacgca aactgttgct cacgccctgg cacctggtgt ttgccgctcg agggccggcg      840

cccgcgccag gcgactttgc accggtgttc gcgcgccggc tacgcgctgg ggactcggtg      900

ctggcgcccg gcggggatgc gcttcggcca gcgcgcgtgg cccgtgtggc gcgggaggaa      960

gccgtgggcg tgttcgcgcc gctcaccgcg cacgggacgc tgctggtgaa cgatgtcctg     1020

gcctcttgct acgcggttct ggagagtcac cagtgggcgc accgcgcttt tgcccccttg     1080

agactgctgc acgcgctagg ggcgctgctc cccggcgggg ccgtccagcc gactggcatg     1140

cattggtact ctcggctcct ctaccgctta gcggaggagc tactgggctg a              1191


<210>  6
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Leu Leu Thr Asn Leu Leu Pro Leu Cys Cys Leu Ala Leu Leu 
1               5                   10                  15      


Ala Leu Pro Ala Gln Ser Cys Gly Pro Gly Arg Gly Pro Val Gly Arg 
            20                  25                  30          


Arg Arg Tyr Ala Arg Lys Gln Leu Val Pro Leu Leu Tyr Lys Gln Phe 
        35                  40                  45              


Val Pro Gly Val Pro Glu Arg Thr Leu Gly Ala Ser Gly Pro Ala Glu 
    50                  55                  60                  


Gly Arg Val Ala Arg Gly Ser Glu Arg Phe Arg Asp Leu Val Pro Asn 
65                  70                  75                  80  


Tyr Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Ser Gly Ala Asp 
                85                  90                  95      


Arg Leu Met Thr Glu Arg Cys Lys Glu Arg Val Asn Ala Leu Ala Ile 
            100                 105                 110         


Ala Val Met Asn Met Trp Pro Gly Val Arg Leu Arg Val Thr Glu Gly 
        115                 120                 125             


Trp Asp Glu Asp Gly His His Ala Gln Asp Ser Leu His Tyr Glu Gly 
    130                 135                 140                 


Arg Ala Leu Asp Ile Thr Thr Ser Asp Arg Asp Arg Asn Lys Tyr Gly 
145                 150                 155                 160 


Leu Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr 
                165                 170                 175     


Glu Ser Arg Asn His Val His Val Ser Val Lys Ala Asp Asn Ser Leu 
            180                 185                 190         


Ala Val Arg Ala Gly Gly Cys Phe Pro Gly Asn Ala Thr Val Arg Leu 
        195                 200                 205             


Trp Ser Gly Glu Arg Lys Gly Leu Arg Glu Leu His Arg Gly Asp Trp 
    210                 215                 220                 


Val Leu Ala Ala Asp Ala Ser Gly Arg Val Val Pro Thr Pro Val Leu 
225                 230                 235                 240 


Leu Phe Leu Asp Arg Asp Leu Gln Arg Arg Ala Ser Phe Val Ala Val 
                245                 250                 255     


Glu Thr Glu Trp Pro Pro Arg Lys Leu Leu Leu Thr Pro Trp His Leu 
            260                 265                 270         


Val Phe Ala Ala Arg Gly Pro Ala Pro Ala Pro Gly Asp Phe Ala Pro 
        275                 280                 285             


Val Phe Ala Arg Arg Leu Arg Ala Gly Asp Ser Val Leu Ala Pro Gly 
    290                 295                 300                 


Gly Asp Ala Leu Arg Pro Ala Arg Val Ala Arg Val Ala Arg Glu Glu 
305                 310                 315                 320 


Ala Val Gly Val Phe Ala Pro Leu Thr Ala His Gly Thr Leu Leu Val 
                325                 330                 335     


Asn Asp Val Leu Ala Ser Cys Tyr Ala Val Leu Glu Ser His Gln Trp 
            340                 345                 350         


Ala His Arg Ala Phe Ala Pro Leu Arg Leu Leu His Ala Leu Gly Ala 
        355                 360                 365             


Leu Leu Pro Gly Gly Ala Val Gln Pro Thr Gly Met His Trp Tyr Ser 
    370                 375                 380                 


Arg Leu Leu Tyr Arg Leu Ala Glu Glu Leu Leu Gly 
385                 390                 395     


<210>  7
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  7
tgctctccca gttctcagac tc                                                22


<210>  8
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  8
ccacaacctt ggctttgg                                                     18


