                         SEQUENCE LISTING

<110>  Codexis, Inc.
       Behrouzian, Behnaz
       Xie, Xinkai
       Chan, Kui
       Zhang, Xiyun
       Mitchell, Vesna
       Hattendorf, Douglas A.
 
<120>  CBH1A VARIANTS

<130>  90834-832291 (005710PC)

<150>  US 61/609,843
<151>  2012-03-12

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  1581
<212>  DNA
<213>  Myceliophthora thermophila

<400>  1
atgtacgcca agttcgcgac cctcgccgcc cttgtggctg gcgccgctgc tcagaacgcc       60

tgcactctga ccgctgagaa ccacccctcg ctgacgtggt ccaagtgcac gtctggcggc      120

agctgcacca gcgtccaggg ttccatcacc atcgacgcca actggcggtg gactcaccgg      180

accgatagcg ccaccaactg ctacgagggc aacaagtggg atacttcgta ctgcagcgat      240

ggtccttctt gcgcctccaa gtgctgcatc gacggcgctg actactcgag cacctatggc      300

atcaccacga gcggtaactc cctgaacctc aagttcgtca ccaagggcca gtactcgacc      360

aacatcggct cgcgtaccta cctgatggag agcgacacca agtaccagat gttccagctc      420

ctcggcaacg agttcacctt cgatgtcgac gtctccaacc tcggctgcgg cctcaatggc      480

gccctctact tcgtgtccat ggatgccgat ggtggcatgt ccaagtactc gggcaacaag      540

gcaggtgcca agtacggtac cggctactgt gattctcagt gcccccgcga cctcaagttc      600

atcaacggcg aggccaacgt agagaactgg cagagctcga ccaacgatgc caacgccggc      660

acgggcaagt acggcagctg ctgctccgag atggacgtct gggaggccaa caacatggcc      720

gccgccttca ctccccaccc ttgcaccgtg atcggccagt cgcgctgcga gggcgactcg      780

tgcggcggta cctacagcac cgaccgctat gccggcatct gcgaccccga cggatgcgac      840

ttcaactcgt accgccaggg caacaagacc ttctacggca agggcatgac ggtcgacacg      900

accaagaaga tcacggtcgt cacccagttc ctcaagaact cggccggcga gctctccgag      960

atcaagcggt tctacgtcca gaacggcaag gtcatcccca actccgagtc caccatcccg     1020

ggcgtcgagg gcaactccat cacccaggac tggtgcgacc gccagaaggc cgccttcggc     1080

gacgtgaccg acttccagga caagggcggc atggtccaga tgggcaaggc cctcgcgggg     1140

cccatggtcc tcgtcatgtc catctgggac gaccacgccg tcaacatgct ctggctcgac     1200

tccacctggc ccatcgacgg cgccggcaag ccgggcgccg agcgcggtgc ctgccccacc     1260

acctcgggcg tccccgctga ggtcgaggcc gaggccccca actccaacgt catcttctcc     1320

aacatccgct tcggccccat cggctccacc gtctccggcc tgcccgacgg cggcagcggc     1380

aaccccaacc cgcccgtcag ctcgtccacc ccggtcccct cctcgtccac cacatcctcc     1440

ggttcctccg gcccgactgg cggcacgggt gtcgctaagc actatgagca atgcggagga     1500

atcgggttca ctggccctac ccagtgcgag agcccctaca cttgcaccaa gctgaatgac     1560

tggtactcgc agtgcctgta a                                               1581


<210>  2
<211>  509
<212>  PRT
<213>  Myceliophthora thermophila

<400>  2

Gln Asn Ala Cys Thr Leu Thr Ala Glu Asn His Pro Ser Leu Thr Trp 
1               5                   10                  15      


Ser Lys Cys Thr Ser Gly Gly Ser Cys Thr Ser Val Gln Gly Ser Ile 
            20                  25                  30          


Thr Ile Asp Ala Asn Trp Arg Trp Thr His Arg Thr Asp Ser Ala Thr 
        35                  40                  45              


Asn Cys Tyr Glu Gly Asn Lys Trp Asp Thr Ser Tyr Cys Ser Asp Gly 
    50                  55                  60                  


Pro Ser Cys Ala Ser Lys Cys Cys Ile Asp Gly Ala Asp Tyr Ser Ser 
65                  70                  75                  80  


Thr Tyr Gly Ile Thr Thr Ser Gly Asn Ser Leu Asn Leu Lys Phe Val 
                85                  90                  95      


Thr Lys Gly Gln Tyr Ser Thr Asn Ile Gly Ser Arg Thr Tyr Leu Met 
            100                 105                 110         


Glu Ser Asp Thr Lys Tyr Gln Met Phe Gln Leu Leu Gly Asn Glu Phe 
        115                 120                 125             


Thr Phe Asp Val Asp Val Ser Asn Leu Gly Cys Gly Leu Asn Gly Ala 
    130                 135                 140                 


Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Met Ser Lys Tyr Ser 
145                 150                 155                 160 


Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln 
                165                 170                 175     


Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Glu Ala Asn Val Glu Asn 
            180                 185                 190         


Trp Gln Ser Ser Thr Asn Asp Ala Asn Ala Gly Thr Gly Lys Tyr Gly 
        195                 200                 205             


Ser Cys Cys Ser Glu Met Asp Val Trp Glu Ala Asn Asn Met Ala Ala 
    210                 215                 220                 


Ala Phe Thr Pro His Pro Cys Thr Val Ile Gly Gln Ser Arg Cys Glu 
225                 230                 235                 240 


Gly Asp Ser Cys Gly Gly Thr Tyr Ser Thr Asp Arg Tyr Ala Gly Ile 
                245                 250                 255     


Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Gln Gly Asn Lys 
            260                 265                 270         


Thr Phe Tyr Gly Lys Gly Met Thr Val Asp Thr Thr Lys Lys Ile Thr 
        275                 280                 285             


Val Val Thr Gln Phe Leu Lys Asn Ser Ala Gly Glu Leu Ser Glu Ile 
    290                 295                 300                 


Lys Arg Phe Tyr Val Gln Asn Gly Lys Val Ile Pro Asn Ser Glu Ser 
305                 310                 315                 320 


Thr Ile Pro Gly Val Glu Gly Asn Ser Ile Thr Gln Asp Trp Cys Asp 
                325                 330                 335     


Arg Gln Lys Ala Ala Phe Gly Asp Val Thr Asp Phe Gln Asp Lys Gly 
            340                 345                 350         


Gly Met Val Gln Met Gly Lys Ala Leu Ala Gly Pro Met Val Leu Val 
        355                 360                 365             


Met Ser Ile Trp Asp Asp His Ala Val Asn Met Leu Trp Leu Asp Ser 
    370                 375                 380                 


Thr Trp Pro Ile Asp Gly Ala Gly Lys Pro Gly Ala Glu Arg Gly Ala 
385                 390                 395                 400 


Cys Pro Thr Thr Ser Gly Val Pro Ala Glu Val Glu Ala Glu Ala Pro 
                405                 410                 415     


Asn Ser Asn Val Ile Phe Ser Asn Ile Arg Phe Gly Pro Ile Gly Ser 
            420                 425                 430         


Thr Val Ser Gly Leu Pro Asp Gly Gly Ser Gly Asn Pro Asn Pro Pro 
        435                 440                 445             


Val Ser Ser Ser Thr Pro Val Pro Ser Ser Ser Thr Thr Ser Ser Gly 
    450                 455                 460                 


Ser Ser Gly Pro Thr Gly Gly Thr Gly Val Ala Lys His Tyr Glu Gln 
465                 470                 475                 480 


Cys Gly Gly Ile Gly Phe Thr Gly Pro Thr Gln Cys Glu Ser Pro Tyr 
                485                 490                 495     


Thr Cys Thr Lys Leu Asn Asp Trp Tyr Ser Gln Cys Leu 
            500                 505                 


<210>  3
<211>  17
<212>  PRT
<213>  Myceliophthora thermophila

<400>  3

Met Tyr Ala Lys Phe Ala Thr Leu Ala Ala Leu Val Ala Gly Ala Ala 
1               5                   10                  15      


Ala 
    


<210>  4
<211>  538
<212>  PRT
<213>  thielavia australiensis

<400>  4

Met Tyr Ala Lys Phe Ala Thr Leu Ala Ala Leu Val Ala Gly Ala Ser 
1               5                   10                  15      


Ala Gln Ala Val Cys Ser Leu Thr Ala Glu Thr His Pro Ser Leu Thr 
            20                  25                  30          


Trp Gln Lys Cys Thr Ala Pro Gly Ser Cys Thr Asn Val Ala Gly Ser 
        35                  40                  45              


Ile Thr Ile Asp Ala Asn Trp Arg Trp Thr His Gln Thr Ser Ser Ala 
    50                  55                  60                  


Thr Asn Cys Tyr Ser Gly Ser Lys Trp Asp Ser Ser Ile Cys Thr Thr 
65                  70                  75                  80  


Gly Thr Asp Cys Ala Ser Lys Cys Cys Ile Asp Gly Ala Glu Tyr Ser 
                85                  90                  95      


Ser Thr Tyr Gly Ile Thr Thr Ser Gly Asn Ala Leu Asn Leu Lys Phe 
            100                 105                 110         


Val Thr Lys Gly Gln Tyr Ser Thr Asn Ile Gly Ser Arg Thr Tyr Leu 
        115                 120                 125             


Met Glu Ser Asp Thr Lys Tyr Gln Met Phe Lys Leu Leu Gly Asn Glu 
    130                 135                 140                 


Phe Thr Phe Asp Val Asp Val Ser Asn Leu Gly Cys Gly Leu Asn Gly 
145                 150                 155                 160 


Ala Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Met Ser Lys Tyr 
                165                 170                 175     


Ser Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ala 
            180                 185                 190         


Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Glu Ala Asn Val Glu 
        195                 200                 205             


Gly Trp Glu Ser Ser Thr Asn Asp Ala Asn Ala Gly Ser Gly Lys Tyr 
    210                 215                 220                 


Gly Ser Cys Cys Thr Glu Met Asp Val Trp Glu Ala Asn Asn Met Ala 
225                 230                 235                 240 


Thr Ala Phe Thr Pro His Pro Cys Thr Thr Ile Gly Gln Thr Arg Cys 
                245                 250                 255     


Glu Gly Asp Thr Cys Gly Gly Thr Tyr Ser Ser Asp Arg Tyr Ala Gly 
            260                 265                 270         


Val Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Gln Gly Asn 
        275                 280                 285             


Lys Thr Phe Tyr Gly Lys Gly Met Thr Val Asp Thr Thr Lys Lys Ile 
    290                 295                 300                 


Thr Val Val Thr Gln Phe Leu Lys Asn Ser Ala Gly Glu Leu Ser Glu 
305                 310                 315                 320 


Ile Lys Arg Phe Tyr Ala Gln Asp Gly Lys Val Ile Pro Asn Ser Glu 
                325                 330                 335     


Ser Thr Ile Ala Gly Ile Pro Gly Asn Ser Ile Thr Lys Ala Tyr Cys 
            340                 345                 350         


Asp Ala Gln Lys Thr Val Phe Gln Asn Thr Asp Asp Phe Thr Ala Lys 
        355                 360                 365             


Gly Gly Leu Val Gln Met Gly Lys Ala Leu Ala Gly Asp Met Val Leu 
    370                 375                 380                 


Val Met Ser Val Trp Asp Asp His Ala Val Asn Met Leu Trp Leu Asp 
385                 390                 395                 400 


Ser Thr Tyr Pro Thr Asp Gln Val Gly Val Ala Gly Ala Glu Arg Gly 
                405                 410                 415     


Ala Cys Pro Thr Thr Ser Gly Val Pro Ser Asp Val Glu Ala Asn Ala 
            420                 425                 430         


Pro Asn Ser Asn Val Ile Phe Ser Asn Ile Arg Phe Gly Pro Ile Gly 
        435                 440                 445             


Ser Thr Val Gln Gly Leu Pro Ser Ser Gly Gly Thr Ser Ser Ser Ser 
    450                 455                 460                 


Ser Ala Ala Pro Gln Ser Thr Ser Thr Lys Ala Ser Thr Thr Thr Ser 
465                 470                 475                 480 


Ala Val Arg Thr Thr Ser Thr Ala Thr Thr Lys Thr Thr Ser Ser Ala 
                485                 490                 495     


Pro Ala Gln Gly Thr Asn Thr Ala Lys His Trp Gln Gln Cys Gly Gly 
            500                 505                 510         


Asn Gly Trp Thr Gly Pro Thr Val Cys Glu Ser Pro Tyr Lys Cys Thr 
        515                 520                 525             


Lys Gln Asn Asp Trp Tyr Ser Gln Cys Leu 
    530                 535             


<210>  5
<211>  525
<212>  PRT
<213>  Humicola grisea

<400>  5

Met Arg Thr Ala Lys Phe Ala Thr Leu Ala Ala Leu Val Ala Ser Ala 
1               5                   10                  15      


Ala Ala Gln Gln Ala Cys Ser Leu Thr Thr Glu Arg His Pro Ser Leu 
            20                  25                  30          


Ser Trp Lys Lys Cys Thr Ala Gly Gly Gln Cys Gln Thr Val Gln Ala 
        35                  40                  45              


Ser Ile Thr Leu Asp Ser Asn Trp Arg Trp Thr His Gln Val Ser Gly 
    50                  55                  60                  


Ser Thr Asn Cys Tyr Thr Gly Asn Lys Trp Asp Thr Ser Ile Cys Thr 
65                  70                  75                  80  


Asp Ala Lys Ser Cys Ala Gln Asn Cys Cys Val Asp Gly Ala Asp Tyr 
                85                  90                  95      


Thr Ser Thr Tyr Gly Ile Thr Thr Asn Gly Asp Ser Leu Ser Leu Lys 
            100                 105                 110         


Phe Val Thr Lys Gly Gln Tyr Ser Thr Asn Val Gly Ser Arg Thr Tyr 
        115                 120                 125             


Leu Met Asp Gly Glu Asp Lys Tyr Gln Thr Phe Glu Leu Leu Gly Asn 
    130                 135                 140                 


Glu Phe Thr Phe Asp Val Asp Val Ser Asn Ile Gly Cys Gly Leu Asn 
145                 150                 155                 160 


Gly Ala Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Leu Ser Arg 
                165                 170                 175     


Tyr Pro Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp 
            180                 185                 190         


Ala Gln Cys Pro Arg Asp Ile Lys Phe Ile Asn Gly Glu Ala Asn Ile 
        195                 200                 205             


Glu Gly Trp Thr Gly Ser Thr Asn Asp Pro Asn Ala Gly Ala Gly Arg 
    210                 215                 220                 


Tyr Gly Thr Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Asn Met 
225                 230                 235                 240 


Ala Thr Ala Phe Thr Pro His Pro Cys Thr Ile Ile Gly Gln Ser Arg 
                245                 250                 255     


Cys Glu Gly Asp Ser Cys Gly Gly Thr Tyr Ser Asn Glu Arg Tyr Ala 
            260                 265                 270         


Gly Val Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Gln Gly 
        275                 280                 285             


Asn Lys Thr Phe Tyr Gly Lys Gly Met Thr Val Asp Thr Thr Lys Lys 
    290                 295                 300                 


Ile Thr Val Val Thr Gln Phe Leu Lys Asp Ala Asn Gly Asp Leu Gly 
305                 310                 315                 320 


Glu Ile Lys Arg Phe Tyr Val Gln Asp Gly Lys Ile Ile Pro Asn Ser 
                325                 330                 335     


Glu Ser Thr Ile Pro Gly Val Glu Gly Asn Ser Ile Thr Gln Asp Trp 
            340                 345                 350         


Cys Asp Arg Gln Lys Val Ala Phe Gly Asp Ile Asp Asp Phe Asn Arg 
        355                 360                 365             


Lys Gly Gly Met Lys Gln Met Gly Lys Ala Leu Ala Gly Pro Met Val 
    370                 375                 380                 


Leu Val Met Ser Ile Trp Asp Asp His Ala Ser Asn Met Leu Trp Leu 
385                 390                 395                 400 


Asp Ser Thr Phe Pro Val Asp Ala Ala Gly Lys Pro Gly Ala Glu Arg 
                405                 410                 415     


Gly Ala Cys Pro Thr Thr Ser Gly Val Pro Ala Glu Val Glu Ala Glu 
            420                 425                 430         


Ala Pro Asn Ser Asn Val Val Phe Ser Asn Ile Arg Phe Gly Pro Ile 
        435                 440                 445             


Gly Ser Thr Val Ala Gly Leu Pro Gly Ala Gly Asn Gly Gly Asn Asn 
    450                 455                 460                 


Gly Gly Asn Pro Pro Pro Pro Thr Thr Thr Thr Ser Ser Ala Pro Ala 
465                 470                 475                 480 


Thr Thr Thr Thr Ala Ser Ala Gly Pro Lys Ala Gly Arg Trp Gln Gln 
                485                 490                 495     


Cys Gly Gly Ile Gly Phe Thr Gly Pro Thr Gln Cys Glu Glu Pro Tyr 
            500                 505                 510         


Thr Cys Thr Lys Leu Asn Asp Trp Tyr Ser Gln Cys Leu 
        515                 520                 525 


<210>  6
<211>  532
<212>  PRT
<213>  Chaetomium thermophilum

<400>  6

Met Met Tyr Lys Lys Phe Ala Ala Leu Ala Ala Leu Val Ala Gly Ala 
1               5                   10                  15      


Ser Ala Gln Gln Ala Cys Ser Leu Thr Ala Glu Asn His Pro Ser Leu 
            20                  25                  30          


Thr Trp Lys Arg Cys Thr Ser Gly Gly Ser Cys Ser Thr Val Asn Gly 
        35                  40                  45              


Ala Val Thr Ile Asp Ala Asn Trp Arg Trp Thr His Thr Val Ser Gly 
    50                  55                  60                  


Ser Thr Asn Cys Tyr Thr Gly Asn Gln Trp Asp Thr Ser Leu Cys Thr 
65                  70                  75                  80  


Asp Gly Lys Ser Cys Ala Gln Thr Cys Cys Val Asp Gly Ala Asp Tyr 
                85                  90                  95      


Ser Ser Thr Tyr Gly Ile Thr Thr Ser Gly Asp Ser Leu Asn Leu Lys 
            100                 105                 110         


Phe Val Thr Lys His Gln Tyr Gly Thr Asn Val Gly Ser Arg Val Tyr 
        115                 120                 125             


Leu Met Glu Asn Asp Thr Lys Tyr Gln Met Phe Glu Leu Leu Gly Asn 
    130                 135                 140                 


Glu Phe Thr Phe Asp Val Asp Val Ser Asn Leu Gly Cys Gly Leu Asn 
145                 150                 155                 160 


Gly Ala Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Met Ser Lys 
                165                 170                 175     


Tyr Ser Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp 
            180                 185                 190         


Ala Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Glu Ala Asn Val 
        195                 200                 205             


Gly Asn Trp Thr Pro Ser Thr Asn Asp Ala Asn Ala Gly Phe Gly Arg 
    210                 215                 220                 


Tyr Gly Ser Cys Cys Ser Glu Met Asp Val Trp Glu Ala Asn Asn Met 
225                 230                 235                 240 


Ala Thr Ala Phe Thr Pro His Pro Cys Thr Thr Val Gly Gln Ser Arg 
                245                 250                 255     


Cys Glu Ala Asp Thr Cys Gly Gly Thr Tyr Ser Ser Asp Arg Tyr Ala 
            260                 265                 270         


Gly Val Cys Asp Pro Asp Gly Cys Asp Phe Asn Ala Tyr Arg Gln Gly 
        275                 280                 285             


Asp Lys Thr Phe Tyr Gly Lys Gly Met Thr Val Asp Thr Asn Lys Lys 
    290                 295                 300                 


Met Thr Val Val Thr Gln Phe His Lys Asn Ser Ala Gly Val Leu Ser 
305                 310                 315                 320 


Glu Ile Lys Arg Phe Tyr Val Gln Asp Gly Lys Ile Ile Ala Asn Ala 
                325                 330                 335     


Glu Ser Lys Ile Pro Gly Asn Pro Gly Asn Ser Ile Thr Gln Glu Tyr 
            340                 345                 350         


Cys Asp Ala Gln Lys Val Ala Phe Ser Asn Thr Asp Asp Phe Asn Arg 
        355                 360                 365             


Lys Gly Gly Met Ala Gln Met Ser Lys Ala Leu Ala Gly Pro Met Val 
    370                 375                 380                 


Leu Val Met Ser Val Trp Asp Asp His Tyr Ala Asn Met Leu Trp Leu 
385                 390                 395                 400 


Asp Ser Thr Tyr Pro Ile Asp Gln Ala Gly Ala Pro Gly Ala Glu Arg 
                405                 410                 415     


Gly Ala Cys Pro Thr Thr Ser Gly Val Pro Ala Glu Ile Glu Ala Gln 
            420                 425                 430         


Val Pro Asn Ser Asn Val Ile Phe Ser Asn Ile Arg Phe Gly Pro Ile 
        435                 440                 445             


Gly Ser Thr Val Pro Gly Leu Asp Gly Ser Asn Pro Gly Asn Pro Thr 
    450                 455                 460                 


Thr Thr Val Val Pro Pro Ala Ser Thr Ser Thr Ser Arg Pro Thr Ser 
465                 470                 475                 480 


Ser Thr Ser Ser Pro Val Ser Thr Pro Thr Gly Gln Pro Gly Gly Cys 
                485                 490                 495     


Thr Thr Gln Lys Trp Gly Gln Cys Gly Gly Ile Gly Tyr Thr Gly Cys 
            500                 505                 510         


Thr Asn Cys Val Ala Gly Thr Thr Cys Thr Gln Leu Asn Pro Trp Tyr 
        515                 520                 525             


Ser Gln Cys Leu 
    530         


<210>  7
<211>  522
<212>  PRT
<213>  Sordaria macrospora

<400>  7

Met Leu Ala Lys Phe Ala Ala Leu Ala Ala Leu Val Ala Ser Ala Asn 
1               5                   10                  15      


Ala Gln Ala Val Cys Ser Leu Thr Ala Glu Thr His Pro Ser Leu Asn 
            20                  25                  30          


Trp Ser Lys Cys Thr Ser Ser Gly Cys Thr Asn Val Ala Gly Ser Val 
        35                  40                  45              


Thr Ile Asp Ala Asn Trp Arg Trp Thr His Thr Leu Ser Gly Ser Thr 
    50                  55                  60                  


Asn Cys Tyr Asn Gly Asn Lys Trp Asp Thr Thr Ile Cys Ser Thr Asn 
65                  70                  75                  80  


Thr Asp Cys Ala Thr Lys Cys Cys Val Asp Gly Ala Glu Tyr Ser Ser 
                85                  90                  95      


Thr Tyr Gly Ile Gln Thr Ser Gly Asn Ser Leu Ser Leu Gln Phe Val 
            100                 105                 110         


Thr Lys Gly Gln Tyr Ser Thr Asn Ile Gly Ser Arg Thr Tyr Leu Met 
        115                 120                 125             


Asn Gly Asn Asp Ala Tyr Gln Gly Phe Glu Leu Leu Gly Asn Glu Phe 
    130                 135                 140                 


Thr Phe Asp Val Asp Val Ser Gly Thr Gly Cys Gly Leu Asn Gly Ala 
145                 150                 155                 160 


Leu Tyr Phe Val Ser Met Asp Leu Asp Gly Gly Lys Ser Lys Tyr Ser 
                165                 170                 175     


Thr Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ala Gln 
            180                 185                 190         


Cys Pro Arg Asp Leu Lys Tyr Ile Asn Gly Val Gly Asn Val Glu Gly 
        195                 200                 205             


Trp Ser Ser Ser Thr Asn Asp Pro Asn Ala Gly Ile Gly Asn His Gly 
    210                 215                 220                 


Thr Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Lys Val Ser Thr 
225                 230                 235                 240 


Ala Phe Thr Pro His Pro Cys Thr Thr Ile Asp Gln His Met Cys Glu 
                245                 250                 255     


Gly Asn Ser Cys Gly Gly Thr Tyr Ser Thr Asp Arg Tyr Gly Gly Thr 
            260                 265                 270         


Cys Asp Ala Asp Gly Cys Asp Phe Asn Ser Tyr Arg Met Gly Asn Thr 
        275                 280                 285             


Thr Phe Tyr Gly Glu Gly Lys Thr Val Asp Thr Arg Ser Lys Phe Thr 
    290                 295                 300                 


Val Val Thr Gln Phe Ile Lys Asn Ser Ala Gly Asp Leu Gly Glu Ile 
305                 310                 315                 320 


Lys Arg Phe Tyr Val Gln Asn Gly Lys Val Ile Glu Asn Ser Gln Ser 
                325                 330                 335     


Asn Ile Ala Gly Val Ser Gly Asn Ser Ile Thr Gln Ser Phe Cys Asp 
            340                 345                 350         


Ala Gln Lys Thr Ala Phe Gly Asp Val Gly Asp Phe Asn Val Lys Gly 
        355                 360                 365             


Gly Leu Lys Gln Met Gly Lys Ala Leu Ala Lys Pro Met Val Leu Val 
    370                 375                 380                 


Met Ser Ile Trp Asp Asp His Ala Ala Asn Met Leu Trp Leu Asp Ser 
385                 390                 395                 400 


Thr Tyr Pro Val Glu Gly Gly Ser Pro Gly Ala Tyr Arg Gly Glu Cys 
                405                 410                 415     


Pro Thr Thr Ser Gly Val Pro Ala Glu Val Glu Ala Asn Ala Pro Asn 
            420                 425                 430         


Ser Lys Val Ile Phe Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr 
        435                 440                 445             


Phe Ser Gly Gly Ser Ser Gly Gly Thr Pro Ser Asn Pro Ser Ser Ser 
    450                 455                 460                 


Val Lys Pro Val Thr Ser Thr Ala Lys Pro Thr Thr Thr Ser Thr Ala 
465                 470                 475                 480 


Ser Asn Pro Ser Gly Thr Gly Ala Ala His Trp Ala Gln Cys Gly Gly 
                485                 490                 495     


Ile Gly Phe Asn Gly Pro Thr Thr Cys Gln Ser Pro Tyr Thr Cys Gln 
            500                 505                 510         


Lys Ile Asn Asp Tyr Tyr Ser Gln Cys Leu 
        515                 520         


<210>  8
<211>  532
<212>  PRT
<213>  Chaetomidium pingtungium

<400>  8

Met Leu Ala Ser Thr Phe Ser Tyr Arg Met Tyr Lys Thr Ala Leu Ile 
1               5                   10                  15      


Leu Ala Ala Leu Leu Gly Ser Gly Gln Ala Gln Gln Val Gly Thr Ser 
            20                  25                  30          


Gln Ala Glu Val His Pro Ser Met Thr Trp Gln Ser Cys Thr Ala Gly 
        35                  40                  45              


Gly Ser Cys Thr Thr Asn Asn Gly Lys Val Val Ile Asp Ala Asn Trp 
    50                  55                  60                  


Arg Trp Val His Lys Val Gly Asp Tyr Thr Asn Cys Tyr Thr Gly Asn 
65                  70                  75                  80  


Thr Trp Asp Thr Thr Ile Cys Pro Asp Asp Ala Thr Cys Ala Ser Asn 
                85                  90                  95      


Cys Ala Leu Glu Gly Ala Asn Tyr Glu Ser Thr Tyr Gly Val Thr Ala 
            100                 105                 110         


Ser Gly Asn Ser Leu Arg Leu Asn Phe Val Thr Thr Ser Gln Gln Lys 
        115                 120                 125             


Asn Ile Gly Ser Arg Leu Tyr Met Met Lys Asp Asp Ser Thr Tyr Glu 
    130                 135                 140                 


Met Phe Lys Leu Leu Asn Gln Glu Phe Thr Phe Asp Val Asp Val Ser 
145                 150                 155                 160 


Asn Leu Pro Cys Gly Leu Asn Gly Ala Leu Tyr Phe Val Ala Met Asp 
                165                 170                 175     


Ala Gly Gly Gly Met Ser Lys Tyr Pro Thr Asn Lys Ala Gly Ala Lys 
            180                 185                 190         


Tyr Gly Thr Gly Tyr Cys Asp Ser Gln Cys Pro Arg Asp Leu Lys Phe 
        195                 200                 205             


Ile Asn Gly Gln Ala Asn Val Glu Gly Trp Gln Pro Ser Ser Asn Asp 
    210                 215                 220                 


Ala Asn Ala Gly Thr Gly Asn His Gly Ser Cys Cys Ala Glu Met Asp 
225                 230                 235                 240 


Ile Trp Glu Ala Asn Ser Ile Ser Thr Ala Phe Thr Pro His Pro Cys 
                245                 250                 255     


Asp Thr Pro Gly Gln Val Met Cys Thr Gly Asp Ala Cys Gly Gly Thr 
            260                 265                 270         


Tyr Ser Ser Asp Arg Tyr Gly Gly Thr Cys Asp Pro Asp Gly Cys Asp 
        275                 280                 285             


Phe Asn Ser Phe Arg Gln Gly Asn Lys Thr Phe Tyr Gly Pro Gly Met 
    290                 295                 300                 


Thr Val Asp Thr Lys Ser Lys Phe Thr Val Val Thr Gln Phe Ile Thr 
305                 310                 315                 320 


Asp Asp Gly Thr Ser Ser Gly Thr Leu Lys Glu Ile Lys Arg Phe Tyr 
                325                 330                 335     


Val Gln Asn Gly Lys Val Ile Pro Asn Ser Glu Ser Thr Trp Thr Gly 
            340                 345                 350         


Val Ser Gly Asn Ser Ile Thr Thr Glu Tyr Cys Thr Ala Gln Lys Ser 
        355                 360                 365             


Leu Phe Gln Asp Gln Asn Val Phe Glu Lys His Gly Gly Leu Glu Gly 
    370                 375                 380                 


Met Gly Ala Ala Leu Ala Gln Gly Met Val Leu Val Met Ser Leu Trp 
385                 390                 395                 400 


Asp Asp His Ser Ala Asn Met Leu Trp Leu Asp Ser Asn Tyr Pro Thr 
                405                 410                 415     


Thr Ala Ser Ser Thr Thr Pro Gly Val Ala Arg Gly Thr Cys Asp Ile 
            420                 425                 430         


Ser Ser Gly Val Pro Ala Asp Val Glu Ala Asn His Pro Asp Ala Tyr 
        435                 440                 445             


Val Val Tyr Ser Asn Ile Lys Val Gly Pro Ile Gly Ser Thr Phe Asn 
    450                 455                 460                 


Ser Gly Gly Ser Asn Pro Gly Gly Gly Thr Thr Thr Thr Thr Thr Thr 
465                 470                 475                 480 


Gln Pro Thr Thr Thr Thr Thr Thr Ala Gly Asn Pro Gly Gly Thr Gly 
                485                 490                 495     


Val Ala Gln His Tyr Gly Gln Cys Gly Gly Ile Gly Trp Thr Gly Pro 
            500                 505                 510         


Thr Thr Cys Ala Ser Pro Tyr Thr Cys Gln Lys Leu Asn Asp Tyr Tyr 
        515                 520                 525             


Ser Gln Cys Leu 
    530         


<210>  9
<211>  454
<212>  PRT
<213>  Botryosphaeria rhodina

<400>  9

Met Leu Thr Gln Ala Val Leu Ala Thr Leu Ala Thr Leu Ala Ala Ser 
1               5                   10                  15      


Gln Gln Val Gly Thr Gln Lys Glu Glu Val His Pro Ser Met Thr Trp 
            20                  25                  30          


Gln Thr Cys Thr Ser Ser Gly Cys Thr Thr Asn Gln Gly Ser Ile Val 
        35                  40                  45              


Val Asp Ala Asn Trp Arg Trp Val His Asn Thr Glu Gly Tyr Thr Asn 
    50                  55                  60                  


Cys Tyr Thr Gly Asn Thr Trp Asn Ala Asp Tyr Cys Thr Asp Asn Thr 
65                  70                  75                  80  


Glu Cys Ala Ser Asn Cys Ala Leu Asp Gly Ala Asp Tyr Ser Gly Thr 
                85                  90                  95      


Tyr Gly Ala Thr Thr Ser Gly Asp Ser Leu Arg Leu Asn Phe Ile Thr 
            100                 105                 110         


Asn Gly Gln Gln Lys Asn Ile Gly Ser Arg Met Tyr Leu Met Gln Asp 
        115                 120                 125             


Asp Glu Thr Tyr Ala Val His Lys Leu Leu Asn Lys Glu Phe Thr Phe 
    130                 135                 140                 


Asp Val Asp Thr Ser Lys Leu Pro Cys Gly Leu Asn Gly Ala Val Tyr 
145                 150                 155                 160 


Phe Val Ser Met Asp Ala Asp Gly Gly Met Ala Lys Phe Pro Asp Asn 
                165                 170                 175     


Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln Cys Pro 
            180                 185                 190         


Arg Asp Leu Lys Phe Ile Asp Gly Lys Ala Asn Val Glu Gly Trp Val 
        195                 200                 205             


Pro Ser Glu Asn Asp Ser Asn Ala Gly Val Gly Asn Leu Gly Ser Cys 
    210                 215                 220                 


Cys Ala Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Thr Ala Tyr 
225                 230                 235                 240 


Thr Pro His Ser Cys Lys Thr Val Ala Gln His Ser Cys Thr Gly Asp 
                245                 250                 255     


Asp Cys Gly Gly Thr Tyr Ser Ala Thr Arg Tyr Ala Gly Asp Cys Asp 
            260                 265                 270         


Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Gln Gly Val Lys Asp Phe 
        275                 280                 285             


Tyr Gly Pro Gly Met Thr Val Asp Ser Asn Ser Val Val Thr Val Val 
    290                 295                 300                 


Thr Gln Phe Ile Thr Asn Asp Gly Thr Ala Ser Gly Thr Leu Ser Glu 
305                 310                 315                 320 


Ile Lys Arg Phe Tyr Val Gln Asn Gly Lys Val Ile Pro Asn Ser Glu 
                325                 330                 335     


Ser Thr Ile Ala Gly Val Ser Gly Asn Ser Ile Thr Ser Ala Tyr Cys 
            340                 345                 350         


Asp Ala Gln Lys Glu Val Phe Gly Asp Asn Thr Ser Phe Gln Asp Gln 
        355                 360                 365             


Gly Gly Leu Ala Ser Met Ser Gln Ala Leu Asn Ala Gly Met Val Leu 
    370                 375                 380                 


Val Met Ser Ile Trp Asp Asp His His Ser Asn Met Leu Trp Leu Asp 
385                 390                 395                 400 


Ser Asp Tyr Pro Val Asp Ala Asp Pro Ser Gln Pro Gly Ile Ser Arg 
                405                 410                 415     


Gly Thr Cys Pro Thr Thr Ser Gly Val Pro Ser Glu Val Glu Glu Ser 
            420                 425                 430         


Ala Ala Ser Ala Tyr Val Val Tyr Ser Asn Ile Lys Val Gly Asp Leu 
        435                 440                 445             


Asn Ser Thr Phe Ser Ala 
    450                 


<210>  10
<211>  458
<212>  PRT
<213>  Trichophaea saccata

<400>  10

Met Gln Arg Leu Leu Val Leu Leu Thr Ser Leu Leu Ala Phe Thr Tyr 
1               5                   10                  15      


Gly Gln Gln Val Gly Thr Gln Gln Ala Glu Val His Pro Ser Met Thr 
            20                  25                  30          


Trp Gln Gln Cys Thr Lys Ser Gly Gly Cys Thr Thr Lys Asn Gly Lys 
        35                  40                  45              


Val Val Ile Asp Ala Asn Trp Arg Trp Val His Asn Val Gly Gly Tyr 
    50                  55                  60                  


Thr Asn Cys Tyr Thr Gly Asn Thr Trp Asp Ser Ser Leu Cys Pro Asp 
65                  70                  75                  80  


Asp Val Thr Cys Ala Lys Asn Cys Ala Leu Asp Gly Ala Asp Tyr Ser 
                85                  90                  95      


Gly Thr Tyr Gly Val Thr Ala Gly Gly Asn Ser Leu Lys Leu Thr Phe 
            100                 105                 110         


Val Thr Lys Gly Gln Tyr Ser Thr Asn Val Gly Ser Arg Leu Tyr Met 
        115                 120                 125             


Leu Ala Asp Asp Ser Thr Tyr Gln Met Tyr Asn Leu Leu Asn Gln Glu 
    130                 135                 140                 


Phe Thr Phe Asp Val Asp Val Ser Asn Leu Pro Cys Gly Leu Asn Gly 
145                 150                 155                 160 


Ala Leu Tyr Phe Val Ser Met Asp Lys Asp Gly Gly Met Ser Lys Tyr 
                165                 170                 175     


Ser Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser 
            180                 185                 190         


Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Gln Gly Asn Val Glu 
        195                 200                 205             


Gly Trp Lys Pro Ser Ser Asn Asp Ala Asn Ala Gly Val Gly Gly His 
    210                 215                 220                 


Gly Ser Cys Cys Ala Glu Met Asp Val Trp Glu Ala Asn Ser Ile Ser 
225                 230                 235                 240 


Ala Ala Val Thr Pro His Ser Cys Ser Thr Thr Ser Gln Thr Met Cys 
                245                 250                 255     


Asn Gly Asp Ser Cys Gly Gly Thr Tyr Ser Ala Thr Arg Tyr Ala Gly 
            260                 265                 270         


Val Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Met Gly Asp 
        275                 280                 285             


Thr Thr Phe Tyr Gly Lys Gly Lys Thr Val Asp Thr Ser Ser Lys Phe 
    290                 295                 300                 


Thr Val Val Thr Gln Phe Ile Thr Asp Thr Gly Thr Ala Ser Gly Ser 
305                 310                 315                 320 


Leu Thr Glu Ile Arg Arg Phe Tyr Val Gln Asn Gly Lys Leu Ile Pro 
                325                 330                 335     


Asn Ser Gln Ser Lys Ile Ser Gly Val Thr Gly Asn Ser Ile Thr Ser 
            340                 345                 350         


Ala Phe Cys Asp Ala Gln Lys Ala Ala Phe Gly Asp Asn Tyr Thr Phe 
        355                 360                 365             


Lys Asp Lys Gly Gly Phe Ala Ser Met Thr Thr Ala Met Lys Asn Gly 
    370                 375                 380                 


Met Val Leu Val Met Ser Leu Trp Asp Asp His Tyr Ala Asn Met Leu 
385                 390                 395                 400 


Trp Leu Asp Ser Asp Tyr Pro Thr Asn Ala Asp Ser Ser Lys Pro Gly 
                405                 410                 415     


Val Ala Arg Gly Thr Cys Pro Thr Ser Ser Gly Val Pro Ser Asp Val 
            420                 425                 430         


Glu Thr Asn Asn Ala Ser Ala Ser Val Thr Tyr Ser Asn Ile Arg Phe 
        435                 440                 445             


Gly Asp Leu Asn Ser Thr Tyr Thr Ala Gln 
    450                 455             


<210>  11
<211>  526
<212>  PRT
<213>  Aspergillus nidulans

<400>  11

Met Ala Ser Ser Phe Gln Leu Tyr Lys Ala Leu Leu Phe Phe Ser Ser 
1               5                   10                  15      


Leu Leu Ser Ala Val Gln Ala Gln Lys Val Gly Thr Gln Gln Ala Glu 
            20                  25                  30          


Val His Pro Gly Leu Thr Trp Gln Thr Cys Thr Ser Ser Gly Ser Cys 
        35                  40                  45              


Thr Thr Val Asn Gly Glu Val Thr Ile Asp Ala Asn Trp Arg Trp Leu 
    50                  55                  60                  


His Thr Val Asn Gly Tyr Thr Asn Cys Tyr Thr Gly Asn Glu Trp Asp 
65                  70                  75                  80  


Thr Ser Ile Cys Thr Ser Asn Glu Val Cys Ala Glu Gln Cys Ala Val 
                85                  90                  95      


Asp Gly Ala Asn Tyr Ala Ser Thr Tyr Gly Ile Thr Thr Ser Gly Ser 
            100                 105                 110         


Ser Leu Arg Leu Asn Phe Val Thr Gln Ser Gln Gln Lys Asn Ile Gly 
        115                 120                 125             


Ser Arg Val Tyr Leu Met Asp Asp Glu Asp Thr Tyr Thr Met Phe Tyr 
    130                 135                 140                 


Leu Leu Asn Lys Glu Phe Thr Phe Asp Val Asp Val Ser Glu Leu Pro 
145                 150                 155                 160 


Cys Gly Leu Asn Gly Ala Val Tyr Phe Val Ser Met Asp Ala Asp Gly 
                165                 170                 175     


Gly Lys Ser Arg Tyr Ala Thr Asn Glu Ala Gly Ala Lys Tyr Gly Thr 
            180                 185                 190         


Gly Tyr Cys Asp Ser Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly 
        195                 200                 205             


Val Ala Asn Val Glu Gly Trp Glu Ser Ser Asp Thr Asn Pro Asn Gly 
    210                 215                 220                 


Gly Val Gly Asn His Gly Ser Cys Cys Ala Glu Met Asp Ile Trp Glu 
225                 230                 235                 240 


Ala Asn Ser Ile Ser Thr Ala Phe Thr Pro His Pro Cys Asp Thr Pro 
                245                 250                 255     


Gly Gln Thr Leu Cys Thr Gly Asp Ser Cys Gly Gly Thr Tyr Ser Asn 
            260                 265                 270         


Asp Arg Tyr Gly Gly Thr Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser 
        275                 280                 285             


Tyr Arg Gln Gly Asn Lys Thr Phe Tyr Gly Pro Gly Leu Thr Val Asp 
    290                 295                 300                 


Thr Asn Ser Pro Val Thr Val Val Thr Gln Phe Leu Thr Asp Asp Asn 
305                 310                 315                 320 


Thr Asp Thr Gly Thr Leu Ser Glu Ile Lys Arg Phe Tyr Val Gln Asn 
                325                 330                 335     


Gly Val Val Ile Pro Asn Ser Glu Ser Thr Tyr Pro Ala Asn Pro Gly 
            340                 345                 350         


Asn Ser Ile Thr Thr Glu Phe Cys Glu Ser Gln Lys Glu Leu Phe Gly 
        355                 360                 365             


Asp Val Asp Val Phe Ser Ala His Gly Gly Met Ala Gly Met Gly Ala 
    370                 375                 380                 


Ala Leu Glu Gln Gly Met Val Leu Val Leu Ser Leu Trp Asp Asp Asn 
385                 390                 395                 400 


Tyr Ser Asn Met Leu Trp Leu Asp Ser Asn Tyr Pro Thr Asp Ala Asp 
                405                 410                 415     


Pro Thr Gln Pro Gly Ile Ala Arg Gly Thr Cys Pro Thr Asp Ser Gly 
            420                 425                 430         


Val Pro Ser Glu Val Glu Ala Gln Tyr Pro Asn Ala Tyr Val Val Tyr 
        435                 440                 445             


Ser Asn Ile Lys Phe Gly Pro Ile Gly Ser Thr Phe Gly Asn Gly Gly 
    450                 455                 460                 


Gly Ser Gly Pro Thr Thr Thr Val Thr Thr Ser Thr Ala Thr Ser Thr 
465                 470                 475                 480 


Thr Ser Ser Ala Thr Ser Thr Ala Thr Gly Gln Ala Gln His Trp Glu 
                485                 490                 495     


Gln Cys Gly Gly Asn Gly Trp Thr Gly Pro Thr Val Cys Ala Ser Pro 
            500                 505                 510         


Trp Ala Cys Thr Val Val Asn Ser Trp Tyr Ser Gln Cys Leu 
        515                 520                 525     


<210>  12
<211>  455
<212>  PRT
<213>  Schizophyllum commune

<400>  12

Met Phe Pro Ala Ala Ala Leu Val Ser Leu Thr Leu Ala Ala Ile Ala 
1               5                   10                  15      


Arg Ala Gln Gln Val Gly Asn Leu Thr Ala Glu Thr His Pro Ser Leu 
            20                  25                  30          


Ser Trp Gln Glu Cys Thr Ser Ser Gly Cys Thr Asp His Ser Ala Ala 
        35                  40                  45              


Ile Thr Ile Asp Ala Asn Trp Arg Trp Leu His Thr Val Glu Gly Tyr 
    50                  55                  60                  


Asp Asn Cys Tyr Thr Gly Asn Glu Trp Asp Glu Ser Val Cys Thr Asp 
65                  70                  75                  80  


Gly Ala Thr Cys Ala Ser Ser Cys Ala Leu Asp Gly Ala Asp Tyr Ser 
                85                  90                  95      


Gly Thr Tyr Gly Ile Thr Thr Ser Gly Asp Ala Leu Ser Leu Lys Phe 
            100                 105                 110         


Val Thr Ser Gly Gln Gln Lys Asn Ile Gly Ser Arg Thr Tyr Leu Met 
        115                 120                 125             


Asn Gly Glu Asp Lys Tyr Gln Met Phe Lys Leu Lys Asn Lys Glu Phe 
    130                 135                 140                 


Thr Phe Thr Val Asp Met Ser Thr Leu Pro Cys Gly Leu Asn Gly Ala 
145                 150                 155                 160 


Leu Tyr Phe Val Glu Met Asp Glu Asp Gly Gly Val Ser Lys Tyr Pro 
                165                 170                 175     


Thr Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln 
            180                 185                 190         


Cys Pro His Asp Ile Lys Phe Ile Asn Gly Glu Ala Asn Ser Glu Gly 
        195                 200                 205             


Trp Ala Gly Ser Asp Asn Asp Pro Asn Ala Gly Thr Gly Thr Tyr Gly 
    210                 215                 220                 


Ser Cys Cys Ser Glu Met Asp Ile Trp Glu Ala Asn Ser Gln Ala Ala 
225                 230                 235                 240 


Ala Tyr Thr Pro His Val Cys Thr Val Glu Gly Gln Thr Arg Cys Glu 
                245                 250                 255     


Gly Thr Asp Cys Gly Asp Asp Asp Asp Arg Tyr Ser Gly Val Cys Asp 
            260                 265                 270         


Lys Asp Gly Cys Asp Phe Asn Ser Tyr Arg Met Gly Asp Thr Thr Phe 
        275                 280                 285             


Leu Gly Glu Gly Leu Thr Ile Asp Thr Thr Gln Pro Ile Thr Val Val 
    290                 295                 300                 


Thr Gln Phe Ile Thr Ala Asp Asn Thr Thr Ser Gly Ala Leu Ser Glu 
305                 310                 315                 320 


Ile Arg Arg Leu Tyr Val Gln Gly Gly Glu Val Val Ala Asn Ser Ala 
                325                 330                 335     


Thr Lys Ile Glu Gly Leu Asp Asp Tyr Asp Ser Ile Thr Asp Gln Phe 
            340                 345                 350         


Cys Ala Asp Gln Lys Glu Val Phe Gly Asp Gln Asn Tyr Phe Gly Thr 
        355                 360                 365             


Leu Gly Gly Leu Glu Ala Met Gly Glu Ser Leu Asp Arg Gly His Val 
    370                 375                 380                 


Leu Val Met Ser Ile Trp Asp Asp His Ala Val Asn Met Leu Trp Leu 
385                 390                 395                 400 


Asp Ser Asp Tyr Pro Leu Asp Lys Asp Pro Ser Glu Pro Gly Val Ser 
                405                 410                 415     


Arg Gly Pro Cys Gly Thr Asp Ser Gly Val Pro Thr Asp Val Glu Ala 
            420                 425                 430         


Gln Ser Pro Asp Ala Thr Val Ile Tyr Ser Ala Ile Lys Phe Gly Asp 
        435                 440                 445             


Ile Gly Thr Thr Tyr Ser Ala 
    450                 455 


<210>  13
<211>  506
<212>  PRT
<213>  Agaricus bisporus

<400>  13

Met Phe Pro Arg Ser Ile Leu Leu Ala Leu Ser Leu Thr Ala Val Ala 
1               5                   10                  15      


Leu Gly Gln Gln Val Gly Thr Asn Met Ala Glu Asn His Pro Ser Leu 
            20                  25                  30          


Thr Trp Gln Arg Cys Thr Ser Ser Gly Cys Gln Asn Val Asn Gly Lys 
        35                  40                  45              


Val Thr Leu Asp Ala Asn Trp Arg Trp Thr His Arg Ile Asn Asp Phe 
    50                  55                  60                  


Thr Asn Cys Tyr Thr Gly Asn Glu Trp Asp Thr Ser Ile Cys Pro Asp 
65                  70                  75                  80  


Gly Val Thr Cys Ala Glu Asn Cys Ala Leu Asp Gly Ala Asp Tyr Ala 
                85                  90                  95      


Gly Thr Tyr Gly Val Thr Ser Ser Gly Thr Ala Leu Thr Leu Lys Phe 
            100                 105                 110         


Val Thr Glu Ser Gln Gln Lys Asn Ile Gly Ser Arg Leu Tyr Leu Met 
        115                 120                 125             


Ala Asp Asp Ser Asn Tyr Glu Ile Phe Asn Leu Leu Asn Lys Glu Phe 
    130                 135                 140                 


Thr Phe Asp Val Asp Val Ser Lys Leu Pro Cys Gly Leu Asn Gly Ala 
145                 150                 155                 160 


Leu Tyr Phe Ser Glu Met Ala Ala Asp Gly Gly Met Ser Ser Thr Asn 
                165                 170                 175     


Thr Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser Gln Cys Pro 
            180                 185                 190         


Arg Asp Ile Lys Phe Ile Asp Gly Glu Ala Asn Ser Glu Gly Trp Glu 
        195                 200                 205             


Gly Ser Pro Asn Asp Val Asn Ala Gly Thr Gly Asn Phe Gly Ala Cys 
    210                 215                 220                 


Cys Gly Glu Met Asp Ile Trp Glu Ala Asn Ser Ile Ser Ser Ala Tyr 
225                 230                 235                 240 


Thr Pro His Pro Cys Arg Glu Pro Gly Leu Gln Arg Cys Glu Gly Asn 
                245                 250                 255     


Thr Cys Ser Val Asn Asp Arg Tyr Ala Thr Glu Cys Asp Pro Asp Gly 
            260                 265                 270         


Cys Asp Phe Asn Ser Phe Arg Met Gly Asp Lys Ser Phe Tyr Gly Pro 
        275                 280                 285             


Gly Met Thr Val Asp Thr Asn Gln Pro Ile Thr Val Val Thr Gln Phe 
    290                 295                 300                 


Ile Thr Asp Asn Gly Ser Asp Asn Gly Asn Leu Gln Glu Ile Arg Arg 
305                 310                 315                 320 


Ile Tyr Val Gln Asn Gly Gln Val Ile Gln Asn Ser Asn Val Asn Ile 
                325                 330                 335     


Pro Gly Ile Asp Ser Gly Asn Ser Ile Ser Ala Glu Phe Cys Asp Gln 
            340                 345                 350         


Ala Lys Glu Ala Phe Gly Asp Glu Arg Ser Phe Gln Asp Arg Gly Gly 
        355                 360                 365             


Leu Ser Gly Met Gly Ser Ala Leu Asp Arg Gly Met Val Leu Val Leu 
    370                 375                 380                 


Ser Ile Trp Asp Asp His Ala Val Asn Met Leu Trp Leu Asp Ser Asp 
385                 390                 395                 400 


Tyr Pro Leu Asp Ala Ser Pro Ser Gln Pro Gly Ile Ser Arg Gly Thr 
                405                 410                 415     


Cys Ser Arg Asp Ser Gly Lys Pro Glu Asp Val Glu Ala Asn Ala Gly 
            420                 425                 430         


Gly Val Gln Val Val Tyr Ser Asn Ile Lys Phe Gly Asp Ile Asn Ser 
        435                 440                 445             


Thr Phe Asn Asn Asn Gly Gly Gly Gly Gly Asn Pro Ser Pro Thr Thr 
    450                 455                 460                 


Thr Arg Pro Asn Ser Pro Ala Gln Thr Met Trp Gly Gln Cys Gly Gly 
465                 470                 475                 480 


Gln Gly Trp Thr Gly Pro Thr Ala Cys Gln Ser Pro Ser Thr Cys His 
                485                 490                 495     


Val Ile Asn Asp Phe Tyr Ser Gln Cys Phe 
            500                 505     


<210>  14
<211>  2487
<212>  DNA
<213>  Myceliophthora thermophila

<400>  14
atgaggacct cctctcgttt aatcggtgcc cttgcggcgg cactcttgcc gtctgccctt       60

gcgcagaaca acgcgccggt aaccttcacc gacccggact cgggcattac cttcaacacg      120

tggggtctcg ccgaggattc tccccagact aagggcggtt tcacttttgg tgttgctctg      180

ccctctgatg ccctcacgac agacgccaag gagttcatcg gttacttgaa atgcgcgagg      240

aacgatgaga gcggttggtg cggtgtctcc ctgggcggcc ccatgaccaa ctcgctcctc      300

atcgcggcct ggccccacga ggacaccgtc tacacctctc tccgcttcgc caccggctat      360

gccatgccgg atgtctacca gggggacgcc gagatcaccc aggtctcctc ctctgtcaac      420

tcgacgcact tcagcctcat cttcaggtgc gagaactgcc tgcaatggag tcaaagcggc      480

gccaccggcg gtgcctccac ctcgaacggc gtgttggtcc tcggctgggt ccaggcattc      540

gccgaccccg gcaacccgac ctgccccgac cagatcaccc tcgagcagca cgacaacggc      600

atgggtatct ggggtgccca gctcaactcc gacgccgcca gcccgtccta caccgagtgg      660

gccgcccagg ccaccaagac cgtcacgggt gactgcggcg gtcccaccga gacctctgtc      720

gtcggtgtcc ccgttccgac gggcgtctcg ttcgattaca tcgtcgtggg cggcggtgcc      780

ggtggcatcc ccgccgccga caagctcagc gaggccggca agagtgtgct gctcatcgag      840

aagggctttg cctcgaccgc caacaccgga ggcactctcg gccccgagtg gctcgagggc      900

cacgacctta cccgctttga cgtgccgggt ctgtgcaacc agatctgggt tgactccaag      960

gggatcgctt gcgaggatac cgaccagatg gctggctgtg tcctcggcgg cggtaccgcc     1020

gtgaatgccg gcctgtggtt caagccctac tcgctcgact gggactacct cttccctagt     1080

ggttggaagt acaaagacgt ccagccggcc atcaaccgcg ccctctcgcg catcccgggc     1140

accgatgctc cctcgaccga cggcaagcgc tactaccaac agggcttcga cgtcctctcc     1200

aagggcctgg ccggcggcgg ctggacctcg gtcacggcca ataacgcgcc agacaagaag     1260

aaccgcacct tctcccatgc ccccttcatg ttcgccggcg gcgagcgcaa cggcccgctg     1320

ggcacctact tccagaccgc caagaagcgc agcaacttca agctctggct caacacgtcg     1380

gtcaagcgcg tcatccgcca gggcggccac atcaccggcg tcgaggtcga gccgttccgc     1440

gacggcggtt accaaggcat cgtccccgtc accaaggtta cgggccgcgt catcctctct     1500

gccggtacct ttggcagtgc aaagatcctg ctgaggagcg gtatcggtcc gaacgatcag     1560

ctgcaggttg tcgcggcctc ggagaaggat ggccctacca tgatcagcaa ctcgtcctgg     1620

atcaacctgc ctgtcggcta caacctggat gaccacctca acaccgacac tgtcatctcc     1680

caccccgacg tcgtgttcta cgacttctac gaggcgtggg acaatcccat ccagtctgac     1740

aaggacagct acctcaactc gcgcacgggc atcctcgccc aagccgctcc caacattggg     1800

cctatgttct gggaagagat caagggtgcg gacggcattg ttcgccagct ccagtggact     1860

gcccgtgtcg agggcagcct gggtgccccc aacggcaaga ccatgaccat gtcgcagtac     1920

ctcggtcgtg gtgccacctc gcgcggccgc atgaccatca ccccgtccct gacaactgtc     1980

gtctcggacg tgccctacct caaggacccc aacgacaagg aggccgtcat ccagggcatc     2040

atcaacctgc agaacgccct caagaacgtc gccaacctga cctggctctt ccccaactcg     2100

accatcacgc cgcgccaata cgttgacagc atggtcgtct ccccgagcaa ccggcgctcc     2160

aaccactgga tgggcaccaa caagatcggc accgacgacg ggcgcaaggg cggctccgcc     2220

gtcgtcgacc tcaacaccaa ggtctacggc accgacaacc tcttcgtcat cgacgcctcc     2280

atcttccccg gcgtgcccac caccaacccc acctcgtaca tcgtgacggc gtcggagcac     2340

gcctcggccc gcatcctcgc cctgcccgac ctcacgcccg tccccaagta cgggcagtgc     2400

ggcggccgcg aatggagcgg cagcttcgtc tgcgccgacg gctccacgtg ccagatgcag     2460

aacgagtggt actcgcagtg cttgtga                                         2487


<210>  15
<211>  828
<212>  PRT
<213>  Myceliophthora thermophila

<400>  15

Met Arg Thr Ser Ser Arg Leu Ile Gly Ala Leu Ala Ala Ala Leu Leu 
1               5                   10                  15      


Pro Ser Ala Leu Ala Gln Asn Asn Ala Pro Val Thr Phe Thr Asp Pro 
            20                  25                  30          


Asp Ser Gly Ile Thr Phe Asn Thr Trp Gly Leu Ala Glu Asp Ser Pro 
        35                  40                  45              


Gln Thr Lys Gly Gly Phe Thr Phe Gly Val Ala Leu Pro Ser Asp Ala 
    50                  55                  60                  


Leu Thr Thr Asp Ala Lys Glu Phe Ile Gly Tyr Leu Lys Cys Ala Arg 
65                  70                  75                  80  


Asn Asp Glu Ser Gly Trp Cys Gly Val Ser Leu Gly Gly Pro Met Thr 
                85                  90                  95      


Asn Ser Leu Leu Ile Ala Ala Trp Pro His Glu Asp Thr Val Tyr Thr 
            100                 105                 110         


Ser Leu Arg Phe Ala Thr Gly Tyr Ala Met Pro Asp Val Tyr Gln Gly 
        115                 120                 125             


Asp Ala Glu Ile Thr Gln Val Ser Ser Ser Val Asn Ser Thr His Phe 
    130                 135                 140                 


Ser Leu Ile Phe Arg Cys Glu Asn Cys Leu Gln Trp Ser Gln Ser Gly 
145                 150                 155                 160 


Ala Thr Gly Gly Ala Ser Thr Ser Asn Gly Val Leu Val Leu Gly Trp 
                165                 170                 175     


Val Gln Ala Phe Ala Asp Pro Gly Asn Pro Thr Cys Pro Asp Gln Ile 
            180                 185                 190         


Thr Leu Glu Gln His Asp Asn Gly Met Gly Ile Trp Gly Ala Gln Leu 
        195                 200                 205             


Asn Ser Asp Ala Ala Ser Pro Ser Tyr Thr Glu Trp Ala Ala Gln Ala 
    210                 215                 220                 


Thr Lys Thr Val Thr Gly Asp Cys Gly Gly Pro Thr Glu Thr Ser Val 
225                 230                 235                 240 


Val Gly Val Pro Val Pro Thr Gly Val Ser Phe Asp Tyr Ile Val Val 
                245                 250                 255     


Gly Gly Gly Ala Gly Gly Ile Pro Ala Ala Asp Lys Leu Ser Glu Ala 
            260                 265                 270         


Gly Lys Ser Val Leu Leu Ile Glu Lys Gly Phe Ala Ser Thr Ala Asn 
        275                 280                 285             


Thr Gly Gly Thr Leu Gly Pro Glu Trp Leu Glu Gly His Asp Leu Thr 
    290                 295                 300                 


Arg Phe Asp Val Pro Gly Leu Cys Asn Gln Ile Trp Val Asp Ser Lys 
305                 310                 315                 320 


Gly Ile Ala Cys Glu Asp Thr Asp Gln Met Ala Gly Cys Val Leu Gly 
                325                 330                 335     


Gly Gly Thr Ala Val Asn Ala Gly Leu Trp Phe Lys Pro Tyr Ser Leu 
            340                 345                 350         


Asp Trp Asp Tyr Leu Phe Pro Ser Gly Trp Lys Tyr Lys Asp Val Gln 
        355                 360                 365             


Pro Ala Ile Asn Arg Ala Leu Ser Arg Ile Pro Gly Thr Asp Ala Pro 
    370                 375                 380                 


Ser Thr Asp Gly Lys Arg Tyr Tyr Gln Gln Gly Phe Asp Val Leu Ser 
385                 390                 395                 400 


Lys Gly Leu Ala Gly Gly Gly Trp Thr Ser Val Thr Ala Asn Asn Ala 
                405                 410                 415     


Pro Asp Lys Lys Asn Arg Thr Phe Ser His Ala Pro Phe Met Phe Ala 
            420                 425                 430         


Gly Gly Glu Arg Asn Gly Pro Leu Gly Thr Tyr Phe Gln Thr Ala Lys 
        435                 440                 445             


Lys Arg Ser Asn Phe Lys Leu Trp Leu Asn Thr Ser Val Lys Arg Val 
    450                 455                 460                 


Ile Arg Gln Gly Gly His Ile Thr Gly Val Glu Val Glu Pro Phe Arg 
465                 470                 475                 480 


Asp Gly Gly Tyr Gln Gly Ile Val Pro Val Thr Lys Val Thr Gly Arg 
                485                 490                 495     


Val Ile Leu Ser Ala Gly Thr Phe Gly Ser Ala Lys Ile Leu Leu Arg 
            500                 505                 510         


Ser Gly Ile Gly Pro Asn Asp Gln Leu Gln Val Val Ala Ala Ser Glu 
        515                 520                 525             


Lys Asp Gly Pro Thr Met Ile Ser Asn Ser Ser Trp Ile Asn Leu Pro 
    530                 535                 540                 


Val Gly Tyr Asn Leu Asp Asp His Leu Asn Thr Asp Thr Val Ile Ser 
545                 550                 555                 560 


His Pro Asp Val Val Phe Tyr Asp Phe Tyr Glu Ala Trp Asp Asn Pro 
                565                 570                 575     


Ile Gln Ser Asp Lys Asp Ser Tyr Leu Asn Ser Arg Thr Gly Ile Leu 
            580                 585                 590         


Ala Gln Ala Ala Pro Asn Ile Gly Pro Met Phe Trp Glu Glu Ile Lys 
        595                 600                 605             


Gly Ala Asp Gly Ile Val Arg Gln Leu Gln Trp Thr Ala Arg Val Glu 
    610                 615                 620                 


Gly Ser Leu Gly Ala Pro Asn Gly Lys Thr Met Thr Met Ser Gln Tyr 
625                 630                 635                 640 


Leu Gly Arg Gly Ala Thr Ser Arg Gly Arg Met Thr Ile Thr Pro Ser 
                645                 650                 655     


Leu Thr Thr Val Val Ser Asp Val Pro Tyr Leu Lys Asp Pro Asn Asp 
            660                 665                 670         


Lys Glu Ala Val Ile Gln Gly Ile Ile Asn Leu Gln Asn Ala Leu Lys 
        675                 680                 685             


Asn Val Ala Asn Leu Thr Trp Leu Phe Pro Asn Ser Thr Ile Thr Pro 
    690                 695                 700                 


Arg Gln Tyr Val Asp Ser Met Val Val Ser Pro Ser Asn Arg Arg Ser 
705                 710                 715                 720 


Asn His Trp Met Gly Thr Asn Lys Ile Gly Thr Asp Asp Gly Arg Lys 
                725                 730                 735     


Gly Gly Ser Ala Val Val Asp Leu Asn Thr Lys Val Tyr Gly Thr Asp 
            740                 745                 750         


Asn Leu Phe Val Ile Asp Ala Ser Ile Phe Pro Gly Val Pro Thr Thr 
        755                 760                 765             


Asn Pro Thr Ser Tyr Ile Val Thr Ala Ser Glu His Ala Ser Ala Arg 
    770                 775                 780                 


Ile Leu Ala Leu Pro Asp Leu Thr Pro Val Pro Lys Tyr Gly Gln Cys 
785                 790                 795                 800 


Gly Gly Arg Glu Trp Ser Gly Ser Phe Val Cys Ala Asp Gly Ser Thr 
                805                 810                 815     


Cys Gln Met Gln Asn Glu Trp Tyr Ser Gln Cys Leu 
            820                 825             


<210>  16
<211>  2364
<212>  DNA
<213>  Myceliophthora thermophila

<400>  16
atgaagctac tcagccgcgt tggggcgacc gccctagcgg cgacgttgtc actgcagcaa       60

tgtgcagccc agatgaccga ggggacctac accgatgagg ctaccggtat ccaattcaag      120

acgtggaccg cctccgaggg cgcccctttc acgtttggct tgaccctccc cgcggacgcg      180

ctggaaaagg atgccaccga gtacattggt ctcctgcgtt gccaaatcac cgatcccgcc      240

tcgcccagct ggtgcggtat ctcccacggc cagtccggcc agatgacgca ggcgctgctg      300

ctggtcgcct gggccagcga ggacaccgtc tacacgtcgt tccgctacgc caccggctac      360

acgctccccg gcctctacac gggcgacgcc aagctgaccc agatctcctc ctcggtcagc      420

gaggacagct tcgaggtgct gttccgctgc gaaaactgct tctcctggga ccaggatggc      480

accaagggca acgtctcgac cagcaacggc aacctggtcc tcggccgcgc cgccgcgaag      540

gatggtgtga cgggccccac gtgcccggac acggccgagt tcggtttcca tgataacggt      600

ttcggacagt ggggtgccgt gcttgagggt gctacttcgg actcgtacga ggagtgggct      660

aagctggcca cgaccacgcc cgagaccacc tgcgatggca ctggccccgg cgacaaggag      720

tgcgttccgg ctcccgagga cacgtatgat tacatcgttg tcggtgccgg cgccggtggt      780

atcaccgtcg ccgacaagct cagcgaggcc ggccacaagg tccttctcat cgagaaggga      840

cccccttcga ccggcctgtg gaacgggacc atgaagcccg agtggctcga gagcaccgac      900

cttacccgct tcgacgttcc cggcctgtgc aaccagatct gggtcgactc tgccggcatc      960

gcctgcaccg ataccgacca gatggcgggc tgcgttctcg gcggtggcac cgctgtcaac     1020

gctggtttgt ggtggaagcc ccaccccgct gactgggatg agaacttccc cgaagggtgg     1080

aagtcgagcg atctcgcgga tgcgaccgag cgtgtcttca agcgcatccc cggcacgtcg     1140

cacccgtcgc aggacggcaa gttgtaccgc caggagggct tcgaggtcat cagcaagggc     1200

ctggccaacg ccggctggaa ggaaatcagc gccaacgagg cgcccagcga gaagaaccac     1260

acctatgcac acaccgagtt catgttctcg ggcggtgagc gtggcggccc cctggcgacg     1320

taccttgcct cggctgccga gcgcagcaac ttcaacctgt ggctcaacac tgccgtccgg     1380

agggccgtcc gcagcggcag caaggtcacc ggcgtcgagc tcgagtgcct cacggacggt     1440

ggcttcagcg ggaccgtcaa cctgaatgag ggcggtggtg tcatcttctc ggccggcgct     1500

ttcggctcgg ccaagctgct ccttcgcagc ggtatcggtc ctgaggacca gctcgagatt     1560

gtggcgagct ccaaggacgg cgagaccttc actcccaagg acgagtggat caacctcccc     1620

gtcggccaca acctgatcga ccatctcaac actgacctca ttatcacgca cccggatgtc     1680

gttttctatg acttctatgc ggcctgggac gagcccatca cggaggataa ggaggcctac     1740

ctgaactcgc ggtccggcat tctcgcccag gcggcgccca atatcggccc tatgatgtgg     1800

gatcaagtca cgccgtccga cggcatcacc cgccagttcc agtggacatg ccgtgttgag     1860

ggcgacagct ccaagaccaa ctcgacccac gccatgaccc tcagccagta cctcggccgt     1920

ggcgtcgtct cgcgcggccg gatgggcatc acctccgggc tgagcacgac ggtggccgag     1980

cacccgtacc tgcacaacaa cggcgacctg gaggcggtca tccaggggat ccagaacgtg     2040

gtggacgcgc tcagccaggt ggccgacctc gagtgggtgc tcccgccgcc cgacgggacg     2100

gtggccgact acgtcaacag cctgatcgtc tcgccggcca accgccgggc caaccactgg     2160

atgggcacgg ccaagctggg caccgacgac ggccgctcgg gcggcacctc ggtcgtcgac     2220

ctcgacacca aggtgtacgg caccgacaac ctgttcgtcg tcgacgcgtc cgtcttcccc     2280

ggcatgtcga cgggcaaccc gtcggccatg atcgtcatcg tggccgagca ggcggcgcag     2340

cgcatcctgg ccctgcggtc ttaa                                            2364


<210>  17
<211>  787
<212>  PRT
<213>  Myceliophthora thermophila

<400>  17

Met Lys Leu Leu Ser Arg Val Gly Ala Thr Ala Leu Ala Ala Thr Leu 
1               5                   10                  15      


Ser Leu Gln Gln Cys Ala Ala Gln Met Thr Glu Gly Thr Tyr Thr Asp 
            20                  25                  30          


Glu Ala Thr Gly Ile Gln Phe Lys Thr Trp Thr Ala Ser Glu Gly Ala 
        35                  40                  45              


Pro Phe Thr Phe Gly Leu Thr Leu Pro Ala Asp Ala Leu Glu Lys Asp 
    50                  55                  60                  


Ala Thr Glu Tyr Ile Gly Leu Leu Arg Cys Gln Ile Thr Asp Pro Ala 
65                  70                  75                  80  


Ser Pro Ser Trp Cys Gly Ile Ser His Gly Gln Ser Gly Gln Met Thr 
                85                  90                  95      


Gln Ala Leu Leu Leu Val Ala Trp Ala Ser Glu Asp Thr Val Tyr Thr 
            100                 105                 110         


Ser Phe Arg Tyr Ala Thr Gly Tyr Thr Leu Pro Gly Leu Tyr Thr Gly 
        115                 120                 125             


Asp Ala Lys Leu Thr Gln Ile Ser Ser Ser Val Ser Glu Asp Ser Phe 
    130                 135                 140                 


Glu Val Leu Phe Arg Cys Glu Asn Cys Phe Ser Trp Asp Gln Asp Gly 
145                 150                 155                 160 


Thr Lys Gly Asn Val Ser Thr Ser Asn Gly Asn Leu Val Leu Gly Arg 
                165                 170                 175     


Ala Ala Ala Lys Asp Gly Val Thr Gly Pro Thr Cys Pro Asp Thr Ala 
            180                 185                 190         


Glu Phe Gly Phe His Asp Asn Gly Phe Gly Gln Trp Gly Ala Val Leu 
        195                 200                 205             


Glu Gly Ala Thr Ser Asp Ser Tyr Glu Glu Trp Ala Lys Leu Ala Thr 
    210                 215                 220                 


Thr Thr Pro Glu Thr Thr Cys Asp Gly Thr Gly Pro Gly Asp Lys Glu 
225                 230                 235                 240 


Cys Val Pro Ala Pro Glu Asp Thr Tyr Asp Tyr Ile Val Val Gly Ala 
                245                 250                 255     


Gly Ala Gly Gly Ile Thr Val Ala Asp Lys Leu Ser Glu Ala Gly His 
            260                 265                 270         


Lys Val Leu Leu Ile Glu Lys Gly Pro Pro Ser Thr Gly Leu Trp Asn 
        275                 280                 285             


Gly Thr Met Lys Pro Glu Trp Leu Glu Ser Thr Asp Leu Thr Arg Phe 
    290                 295                 300                 


Asp Val Pro Gly Leu Cys Asn Gln Ile Trp Val Asp Ser Ala Gly Ile 
305                 310                 315                 320 


Ala Cys Thr Asp Thr Asp Gln Met Ala Gly Cys Val Leu Gly Gly Gly 
                325                 330                 335     


Thr Ala Val Asn Ala Gly Leu Trp Trp Lys Pro His Pro Ala Asp Trp 
            340                 345                 350         


Asp Glu Asn Phe Pro Glu Gly Trp Lys Ser Ser Asp Leu Ala Asp Ala 
        355                 360                 365             


Thr Glu Arg Val Phe Lys Arg Ile Pro Gly Thr Ser His Pro Ser Gln 
    370                 375                 380                 


Asp Gly Lys Leu Tyr Arg Gln Glu Gly Phe Glu Val Ile Ser Lys Gly 
385                 390                 395                 400 


Leu Ala Asn Ala Gly Trp Lys Glu Ile Ser Ala Asn Glu Ala Pro Ser 
                405                 410                 415     


Glu Lys Asn His Thr Tyr Ala His Thr Glu Phe Met Phe Ser Gly Gly 
            420                 425                 430         


Glu Arg Gly Gly Pro Leu Ala Thr Tyr Leu Ala Ser Ala Ala Glu Arg 
        435                 440                 445             


Ser Asn Phe Asn Leu Trp Leu Asn Thr Ala Val Arg Arg Ala Val Arg 
    450                 455                 460                 


Ser Gly Ser Lys Val Thr Gly Val Glu Leu Glu Cys Leu Thr Asp Gly 
465                 470                 475                 480 


Gly Phe Ser Gly Thr Val Asn Leu Asn Glu Gly Gly Gly Val Ile Phe 
                485                 490                 495     


Ser Ala Gly Ala Phe Gly Ser Ala Lys Leu Leu Leu Arg Ser Gly Ile 
            500                 505                 510         


Gly Pro Glu Asp Gln Leu Glu Ile Val Ala Ser Ser Lys Asp Gly Glu 
        515                 520                 525             


Thr Phe Thr Pro Lys Asp Glu Trp Ile Asn Leu Pro Val Gly His Asn 
    530                 535                 540                 


Leu Ile Asp His Leu Asn Thr Asp Leu Ile Ile Thr His Pro Asp Val 
545                 550                 555                 560 


Val Phe Tyr Asp Phe Tyr Ala Ala Trp Asp Glu Pro Ile Thr Glu Asp 
                565                 570                 575     


Lys Glu Ala Tyr Leu Asn Ser Arg Ser Gly Ile Leu Ala Gln Ala Ala 
            580                 585                 590         


Pro Asn Ile Gly Pro Met Met Trp Asp Gln Val Thr Pro Ser Asp Gly 
        595                 600                 605             


Ile Thr Arg Gln Phe Gln Trp Thr Cys Arg Val Glu Gly Asp Ser Ser 
    610                 615                 620                 


Lys Thr Asn Ser Thr His Ala Met Thr Leu Ser Gln Tyr Leu Gly Arg 
625                 630                 635                 640 


Gly Val Val Ser Arg Gly Arg Met Gly Ile Thr Ser Gly Leu Ser Thr 
                645                 650                 655     


Thr Val Ala Glu His Pro Tyr Leu His Asn Asn Gly Asp Leu Glu Ala 
            660                 665                 670         


Val Ile Gln Gly Ile Gln Asn Val Val Asp Ala Leu Ser Gln Val Ala 
        675                 680                 685             


Asp Leu Glu Trp Val Leu Pro Pro Pro Asp Gly Thr Val Ala Asp Tyr 
    690                 695                 700                 


Val Asn Ser Leu Ile Val Ser Pro Ala Asn Arg Arg Ala Asn His Trp 
705                 710                 715                 720 


Met Gly Thr Ala Lys Leu Gly Thr Asp Asp Gly Arg Ser Gly Gly Thr 
                725                 730                 735     


Ser Val Val Asp Leu Asp Thr Lys Val Tyr Gly Thr Asp Asn Leu Phe 
            740                 745                 750         


Val Val Asp Ala Ser Val Phe Pro Gly Met Ser Thr Gly Asn Pro Ser 
        755                 760                 765             


Ala Met Ile Val Ile Val Ala Glu Gln Ala Ala Gln Arg Ile Leu Ala 
    770                 775                 780                 


Leu Arg Ser 
785         


<210>  18
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide for M. thermophila CBH1a variant 24

<400>  18

Met Tyr Ala Lys Phe Ala Thr Leu Ala Ala Leu Val Ala Gly Ala Ala 
1               5                   10                  15      


Ala Gln Asn Ala Cys Thr Leu Thr Ala Glu Asn His Pro Ser Leu Thr 
            20                  25                  30          


Trp Ser Lys Cys Thr Ser Gly Gly Ser Cys Thr Ser Val Gln Gly Ser 
        35                  40                  45              


Ile Thr Ile Asp Ala Asn Trp Arg Trp Thr His Arg Thr Asp Ser Ala 
    50                  55                  60                  


Thr Asn Cys Tyr Glu Gly Asn Lys Trp Asp Thr Ser Trp Cys Ser Asp 
65                  70                  75                  80  


Gly Pro Ser Cys Ala Ser Lys Cys Cys Ile Asp Gly Ala Asp Tyr Ser 
                85                  90                  95      


Ser Thr Tyr Gly Ile Thr Thr Ser Gly Asn Ser Leu Asn Leu Lys Phe 
            100                 105                 110         


Val Thr Lys Gly Gln Tyr Ser Thr Asn Ile Gly Ser Arg Thr Tyr Leu 
        115                 120                 125             


Met Glu Ser Asp Thr Lys Tyr Gln Met Phe Gln Leu Leu Gly Asn Glu 
    130                 135                 140                 


Phe Thr Phe Asp Val Asp Val Ser Asn Leu Gly Cys Gly Leu Asn Gly 
145                 150                 155                 160 


Ala Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Met Ser Lys Tyr 
                165                 170                 175     


Ser Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser 
            180                 185                 190         


Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Glu Ala Asn Val Glu 
        195                 200                 205             


Asn Trp Gln Ser Ser Thr Asn Asp Ala Asn Ala Gly Thr Gly Lys Tyr 
    210                 215                 220                 


Gly Ser Cys Cys Ser Glu Met Asp Val Trp Glu Ala Asn Asn Met Ala 
225                 230                 235                 240 


Ala Ala Phe Thr Pro His Pro Cys Thr Val Ile Gly Gln Ser Arg Cys 
                245                 250                 255     


Glu Gly Asp Ser Cys Gly Gly Thr Tyr Ser Thr Asp Arg Tyr Ala Gly 
            260                 265                 270         


Ile Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Gln Gly Asn 
        275                 280                 285             


Lys Thr Phe Tyr Gly Lys Gly Met Thr Val Asp Thr Thr Lys Lys Ile 
    290                 295                 300                 


Thr Val Val Thr Gln Phe Leu Lys Asn Ser Ala Gly Glu Leu Ser Glu 
305                 310                 315                 320 


Ile Lys Arg Phe Tyr Val Gln Asn Gly Lys Val Ile Pro Asn Ser Glu 
                325                 330                 335     


Ser Thr Ile Pro Gly Val Glu Gly Asn Ser Ile Thr Gln Asp Trp Cys 
            340                 345                 350         


Asp Arg Gln Lys Ala Ala Phe Gly Asp Val Thr Asp Phe Gln Asp Lys 
        355                 360                 365             


Gly Gly Met Val Gln Met Gly Lys Ala Leu Ala Gly Pro Met Val Leu 
    370                 375                 380                 


Val Met Ser Ile Trp Asp Asp His Ala Val Asn Met Leu Trp Leu Asp 
385                 390                 395                 400 


Ser Thr Trp Pro Ile Asp Gly Ala Gly Lys Pro Gly Ala Glu Arg Gly 
                405                 410                 415     


Ala Cys Pro Thr Thr Ser Gly Val Pro Ala Glu Val Glu Ala Glu Ala 
            420                 425                 430         


Pro Asn Ser Asn Val Ile Phe Ser Asn Ile Arg Phe Gly Pro Ile Gly 
        435                 440                 445             


Ser Thr Val Ser Gly Leu Pro Asp Gly Gly Ser Gly Asn Pro Asn Pro 
    450                 455                 460                 


Pro Val Ser Ser Ser Thr Pro Val Pro Ser Ser Ser Thr Thr Ser Ser 
465                 470                 475                 480 


Gly Ser Ser Gly Pro Thr Gly Gly Thr Gly Val Ala Lys His Tyr Glu 
                485                 490                 495     


Gln Cys Gly Gly Ile Gly Phe Thr Gly Pro Thr Gln Cys Glu Ser Pro 
            500                 505                 510         


Tyr Thr Cys Thr Lys Leu Asn Asp Trp Tyr Ser Gln Cys Leu 
        515                 520                 525     


<210>  19
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide for M. thermophila CBH1a variant 207

<400>  19

Met Tyr Ala Lys Phe Ala Thr Leu Ala Ala Leu Val Ala Gly Ala Ala 
1               5                   10                  15      


Ala Gln Asn Ala Cys Thr Leu Asn Ala Glu Asn His Pro Ser Leu Thr 
            20                  25                  30          


Trp Ser Lys Cys Thr Ser Gly Gly Ser Cys Thr Ser Val Gln Gly Ser 
        35                  40                  45              


Ile Thr Ile Asp Ala Asn Trp Arg Trp Thr His Arg Thr Asp Ser Ala 
    50                  55                  60                  


Thr Asn Cys Tyr Glu Gly Asn Lys Trp Asp Thr Ser Tyr Cys Ser Asp 
65                  70                  75                  80  


Gly Pro Ser Cys Ala Ser Lys Cys Cys Ile Asp Gly Ala Asp Tyr Ser 
                85                  90                  95      


Ser Thr Tyr Gly Ile Thr Thr Ser Gly Asn Ser Leu Asn Leu Lys Phe 
            100                 105                 110         


Val Thr Lys Gly Gln Tyr Ser Thr Asn Ile Gly Ser Arg Thr Tyr Leu 
        115                 120                 125             


Met Glu Ser Asp Thr Lys Tyr Gln Met Phe Gln Leu Leu Gly Asn Glu 
    130                 135                 140                 


Phe Thr Phe Asp Val Asp Val Ser Asn Leu Gly Cys Gly Leu Asn Gly 
145                 150                 155                 160 


Ala Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Met Ser Lys Tyr 
                165                 170                 175     


Ser Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser 
            180                 185                 190         


Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Glu Ala Asn Val Glu 
        195                 200                 205             


Asn Trp Gln Ser Ser Thr Asn Asp Ala Asn Ala Gly Thr Gly Lys Tyr 
    210                 215                 220                 


Gly Ser Cys Cys Ser Glu Met Asp Val Trp Glu Ala Asn Asn Met Ala 
225                 230                 235                 240 


Ala Ala Phe Thr Pro His Pro Cys Thr Val Ile Gly Gln Ser Arg Cys 
                245                 250                 255     


Glu Gly Asp Ser Cys Gly Gly Thr Tyr Ser Thr Asp Arg Tyr Ala Gly 
            260                 265                 270         


Ile Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Gln Gly Asn 
        275                 280                 285             


Lys Thr Phe Tyr Gly Lys Gly Met Thr Val Asp Thr Thr Lys Lys Ile 
    290                 295                 300                 


Thr Val Val Thr Gln Phe Leu Lys Asn Ser Ala Gly Glu Leu Ser Glu 
305                 310                 315                 320 


Ile Lys Arg Phe Tyr Val Gln Asn Gly Lys Val Ile Pro Asn Ser Glu 
                325                 330                 335     


Ser Thr Ile Pro Gly Val Glu Gly Asn Ser Ile Thr Gln Asp Trp Cys 
            340                 345                 350         


Asp Arg Gln Lys Ala Ala Phe Gly Asp Val Thr Asp Phe Gln Asp Lys 
        355                 360                 365             


Gly Gly Met Val Gln Met Gly Lys Ala Leu Glu Gly Pro Met Val Leu 
    370                 375                 380                 


Val Met Ser Ile Trp Asp Asp His Ala Asp Asn Met Leu Trp Leu Asp 
385                 390                 395                 400 


Ser Thr Trp Pro Ile Asp Gly Ala Gly Lys Pro Gly Ala Glu Arg Gly 
                405                 410                 415     


Ala Cys Pro Thr Thr Ser Gly Val Pro Ala Glu Val Glu Ala Glu Ala 
            420                 425                 430         


Pro Asn Ser Asn Val Ile Phe Ser Asn Ile Arg Phe Gly Pro Ile Gly 
        435                 440                 445             


Ser Thr Val Ser Gly Leu Pro Asp Gly Gly Ser Gly Asn Pro Asn Pro 
    450                 455                 460                 


Pro Val Ser Ser Ser Thr Pro Val Pro Ser Ser Ser Thr Thr Ser Ser 
465                 470                 475                 480 


Gly Ser Ser Gly Pro Thr Gly Gly Thr Gly Val Ala Lys His Tyr Glu 
                485                 490                 495     


Gln Cys Gly Gly Ile Gly Phe Thr Gly Pro Thr Gln Cys Glu Ser Pro 
            500                 505                 510         


Tyr Thr Cys Thr Lys Leu Asn Asp Trp Tyr Ser Gln Cys Leu 
        515                 520                 525     


<210>  20
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide for M. thermophila CBH1a variant 208

<400>  20

Met Tyr Ala Lys Phe Ala Thr Leu Ala Ala Leu Val Ala Gly Ala Ala 
1               5                   10                  15      


Ala Gln Asn Ala Cys Thr Leu Asn Ala Glu Asn His Pro Ser Leu Thr 
            20                  25                  30          


Trp Ser Lys Cys Thr Ser Gly Gly Ser Cys Thr Ser Val Gln Gly Ser 
        35                  40                  45              


Ile Thr Ile Asp Ala Asn Trp Arg Trp Thr His Arg Thr Asp Ser Ala 
    50                  55                  60                  


Thr Asn Cys Tyr Glu Gly Asn Lys Trp Asp Thr Ser Tyr Cys Ser Asp 
65                  70                  75                  80  


Gly Pro Ser Cys Ala Ser Lys Cys Cys Ile Asp Gly Ala Asp Tyr Ser 
                85                  90                  95      


Ser Thr Tyr Gly Ile Thr Thr Ser Gly Asn Ser Leu Asn Leu Lys Phe 
            100                 105                 110         


Val Thr Lys Gly Gln Tyr Ser Thr Asn Ile Gly Ser Arg Thr Tyr Leu 
        115                 120                 125             


Met Glu Ser Asp Thr Lys Tyr Gln Met Phe Gln Leu Leu Gly Asn Glu 
    130                 135                 140                 


Phe Thr Phe Asp Val Asp Val Ser Asn Leu Gly Cys Gly Leu Asn Gly 
145                 150                 155                 160 


Ala Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Met Ser Lys Tyr 
                165                 170                 175     


Ser Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser 
            180                 185                 190         


Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Glu Ala Asn Val Glu 
        195                 200                 205             


Asn Trp Gln Ser Ser Thr Asn Asp Ala Asn Ala Gly Thr Gly Lys Tyr 
    210                 215                 220                 


Gly Ser Cys Cys Ser Glu Met Asp Val Trp Glu Ala Asn Asn Met Ala 
225                 230                 235                 240 


Ala Ala Phe Thr Pro His Pro Cys Thr Val Ile Gly Gln Ser Arg Cys 
                245                 250                 255     


Glu Gly Asp Ser Cys Gly Gly Thr Tyr Ser Thr Asp Arg Tyr Ala Gly 
            260                 265                 270         


Ile Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Gln Gly Asn 
        275                 280                 285             


Lys Thr Phe Tyr Gly Lys Gly Met Thr Val Asp Thr Thr Lys Lys Ile 
    290                 295                 300                 


Thr Val Val Thr Gln Phe Leu Lys Asn Ser Ala Gly Glu Leu Ser Glu 
305                 310                 315                 320 


Ile Lys Arg Phe Tyr Val Gln Asn Gly Lys Val Ile Pro Asn Ser Glu 
                325                 330                 335     


Ser Thr Ile Pro Gly Val Glu Gly Asn Ser Ile Thr Gln Glu Tyr Cys 
            340                 345                 350         


Asp Arg Gln Lys Ala Ala Phe Gly Asp Val Thr Asp Phe Gln Asp Lys 
        355                 360                 365             


Gly Gly Met Val Gln Met Gly Lys Ala Leu Ala Gly Pro Met Val Leu 
    370                 375                 380                 


Val Met Ser Ile Trp Asp Asp His Ala Asp Asn Met Leu Trp Leu Asp 
385                 390                 395                 400 


Ser Thr Trp Pro Ile Asp Gly Ala Gly Lys Pro Gly Ala Glu Arg Gly 
                405                 410                 415     


Ala Cys Pro Thr Thr Ser Gly Val Pro Ala Glu Val Glu Ala Glu Ala 
            420                 425                 430         


Pro Asn Ser Asn Val Ile Phe Ser Asn Ile Arg Phe Gly Pro Ile Gly 
        435                 440                 445             


Ser Thr Val Ser Gly Leu Pro Asp Gly Gly Ser Gly Asn Pro Asn Pro 
    450                 455                 460                 


Pro Val Ser Ser Ser Thr Pro Val Pro Ser Ser Ser Thr Thr Ser Ser 
465                 470                 475                 480 


Gly Ser Ser Gly Pro Thr Gly Gly Thr Gly Val Ala Lys His Tyr Glu 
                485                 490                 495     


Gln Cys Gly Gly Ile Gly Phe Thr Gly Pro Thr Gln Cys Glu Ser Pro 
            500                 505                 510         


Tyr Thr Cys Thr Lys Leu Asn Asp Trp Tyr Ser Gln Cys Leu 
        515                 520                 525     


<210>  21
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide for M. thermophila CBH1a variant 251

<400>  21

Met Tyr Ala Lys Phe Ala Thr Leu Ala Ala Leu Val Ala Gly Ala Ala 
1               5                   10                  15      


Ala Gln Asn Ala Cys Thr Leu Thr Ala Glu Asn His Pro Ser Leu Thr 
            20                  25                  30          


Trp Ser Lys Cys Thr Ser Gly Gly Ser Cys Thr Ser Val Gln Gly Ser 
        35                  40                  45              


Ile Thr Ile Asp Ala Asn Trp Arg Trp Thr His Arg Thr Asp Ser Ala 
    50                  55                  60                  


Thr Asn Cys Tyr Glu Gly Asn Lys Trp Asp Thr Ser Tyr Cys Ser Asp 
65                  70                  75                  80  


Gly Pro Ser Cys Ala Ser Lys Cys Cys Ile Asp Gly Ala Asp Tyr Ser 
                85                  90                  95      


Ser Thr Tyr Gly Ile Thr Thr Ser Gly Asn Ser Leu Asn Leu Lys Phe 
            100                 105                 110         


Val Thr Lys Gly Gln Tyr Ser Thr Asn Ile Gly Ser Arg Thr Tyr Leu 
        115                 120                 125             


Met Glu Ser Asp Thr Lys Tyr Gln Met Phe Gln Leu Leu Gly Asn Glu 
    130                 135                 140                 


Phe Thr Phe Asp Val Asp Val Ser Asn Leu Gly Cys Gly Leu Asn Gly 
145                 150                 155                 160 


Ala Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Met Ser Lys Tyr 
                165                 170                 175     


Ser Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser 
            180                 185                 190         


Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Glu Ala Asn Val Glu 
        195                 200                 205             


Asn Trp Gln Ser Ser Thr Asn Asp Ala Asn Ala Gly Glu Gly Lys Tyr 
    210                 215                 220                 


Gly Ser Cys Cys Ser Glu Met Asp Val Trp Glu Ala Asn Asn Met Ala 
225                 230                 235                 240 


Ala Ala Phe Thr Pro His Pro Cys Thr Val Ile Gly Gln Ser Arg Cys 
                245                 250                 255     


Glu Gly Asp Ser Cys Gly Gly Thr Tyr Ser Thr Asp Arg Tyr Ala Gly 
            260                 265                 270         


Ile Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Gln Gly Asn 
        275                 280                 285             


Lys Thr Phe Tyr Gly Lys Gly Met Thr Val Asp Thr Thr Lys Lys Ile 
    290                 295                 300                 


Thr Val Val Thr Gln Phe Leu Lys Asn Ser Ala Gly Glu Leu Ser Glu 
305                 310                 315                 320 


Ile Lys Arg Phe Tyr Val Gln Asn Gly Lys Val Ile Pro Asn Ser Glu 
                325                 330                 335     


Ser Thr Ile Pro Gly Val Glu Gly Asn Ser Ile Thr Gln Asp Trp Cys 
            340                 345                 350         


Asp Arg Gln Lys Ala Ala Phe Gly Asp Val Thr Asp Phe Gln Asp Lys 
        355                 360                 365             


Gly Gly Met Val Gln Met Gly Lys Ala Leu Ala Gly Pro Met Val Leu 
    370                 375                 380                 


Val Met Ser Ile Trp Asp Asp His Ala Val Asn Met Leu Trp Leu Asp 
385                 390                 395                 400 


Ser Thr Trp Pro Ile Asp Gly Ala Gly Lys Pro Gly Ala Glu Arg Gly 
                405                 410                 415     


Ala Cys Pro Thr Thr Ser Gly Val Pro Ala Asn Val Glu Ala Glu Ala 
            420                 425                 430         


Pro Asn Ser Asn Val Ile Phe Ser Asn Ile Arg Phe Gly Pro Ile Gly 
        435                 440                 445             


Ser Thr Val Ser Gly Leu Pro Asp Gly Gly Ser Gly Asn Pro Asn Pro 
    450                 455                 460                 


Pro Val Ser Ser Ser Thr Pro Val Pro Ser Ser Ser Thr Thr Ser Ser 
465                 470                 475                 480 


Gly Ser Ser Gly Pro Thr Gly Gly Thr Gly Val Ala Lys His Tyr Glu 
                485                 490                 495     


Gln Cys Gly Gly Ile Gly Phe Thr Gly Pro Thr Gln Cys Glu Ser Pro 
            500                 505                 510         


Tyr Thr Cys Thr Lys Leu Asn Asp Trp Tyr Ser Gln Cys Leu 
        515                 520                 525     


<210>  22
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide for M. thermophila CBH1a variant 472

<400>  22

Met Tyr Ala Lys Phe Ala Thr Leu Ala Ala Leu Val Ala Gly Ala Ala 
1               5                   10                  15      


Ala Gln Asn Ala Cys Thr Leu Thr Ala Glu Asn His Pro Ser Leu Thr 
            20                  25                  30          


Trp Ser Lys Cys Thr Ser Gly Gly Ser Cys Thr Ser Val Gln Gly Ser 
        35                  40                  45              


Ile Thr Ile Asp Ala Asn Trp Arg Trp Thr His Arg Thr Asp Ser Ala 
    50                  55                  60                  


Thr Asn Cys Tyr Glu Gly Met Tyr Ala Lys Phe Ala Thr Leu Ala Ala 
65                  70                  75                  80  


Leu Val Ala Gly Ala Ala Ala Gln Asn Ala Cys Thr Leu Asn Ala Glu 
                85                  90                  95      


Asn His Pro Ser Leu Thr Trp Ser Lys Cys Thr Ser Gly Gly Ser Cys 
            100                 105                 110         


Thr Ser Val Gln Gly Ser Ile Thr Ile Asp Ala Asn Trp Arg Trp Val 
        115                 120                 125             


His Arg Thr Asp Ser Ala Thr Asn Cys Tyr Glu Gly Asn Lys Trp Asp 
    130                 135                 140                 


Thr Ser Tyr Cys Ser Asp Gly Pro Ser Cys Ala Ser Lys Cys Cys Ile 
145                 150                 155                 160 


Asp Gly Ala Asp Tyr Ser Ser Thr Tyr Gly Ile Thr Thr Ser Gly Asn 
                165                 170                 175     


Ser Leu Asn Leu Lys Phe Val Thr Lys Gly Gln Tyr Ser Thr Asn Ile 
            180                 185                 190         


Gly Ser Arg Thr Tyr Leu Met Glu Ser Asp Thr Lys Tyr Gln Met Phe 
        195                 200                 205             


Gln Leu Leu Gly Asn Glu Phe Thr Phe Asp Val Asp Val Ser Asn Leu 
    210                 215                 220                 


Gly Cys Gly Leu Asn Gly Ala Leu Tyr Phe Val Ser Met Asp Ala Asp 
225                 230                 235                 240 


Gly Gly Met Ser Lys Tyr Ser Gly Asn Lys Ala Gly Ala Lys Tyr Gly 
                245                 250                 255     


Thr Gly Tyr Cys Asp Ser Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn 
            260                 265                 270         


Gly Glu Ala Asn Val Glu Asn Trp Gln Ser Ser Thr Asn Asp Ala Asn 
        275                 280                 285             


Ala Gly Thr Gly Lys Tyr Gly Ser Cys Cys Ser Glu Met Asp Val Trp 
    290                 295                 300                 


Glu Ala Asn Asn Met Ala Ala Ala Phe Thr Pro His Pro Cys Thr Val 
305                 310                 315                 320 


Ile Gly Gln Ser Arg Cys Glu Gly Asp Ser Cys Gly Gly Thr Tyr Ser 
                325                 330                 335     


Thr Asp Arg Tyr Ala Gly Ile Cys Asp Pro Asp Gly Cys Asp Phe Asn 
            340                 345                 350         


Ser Tyr Arg Gln Gly Asn Lys Thr Phe Tyr Gly Lys Gly Met Thr Val 
        355                 360                 365             


Asp Thr Thr Lys Lys Ile Thr Val Val Thr Gln Phe Leu Lys Asn Ser 
    370                 375                 380                 


Ala Gly Glu Leu Ser Glu Ile Lys Arg Phe Tyr Val Gln Asn Gly Lys 
385                 390                 395                 400 


Val Ile Pro Asn Ser Glu Ser Thr Ile Pro Gly Val Glu Gly Asn Ser 
                405                 410                 415     


Ile Thr Gln Glu Tyr Cys Asp Arg Gln Lys Ala Ala Phe Gly Asp Val 
            420                 425                 430         


Asp Asp Phe Gln Asp Lys Gly Gly Met Val Gln Met Gly Lys Ala Leu 
        435                 440                 445             


Ala Gly Pro Met Val Leu Val Met Ser Ile Trp Asp Asp His Ala Asp 
    450                 455                 460                 


Asn Met Leu Trp Leu Asp Ser Thr Trp Pro Ile Asp Gly Ala Gly Lys 
465                 470                 475                 480 


Pro Gly Ala Glu Arg Gly Ala Cys Pro Thr Thr Ser Gly Val Pro Ala 
                485                 490                 495     


Glu Val Glu Ala Glu Ala Pro Asn Ser Asn Val Ile Phe Ser Asn Ile 
            500                 505                 510         


Arg Phe Gly Pro Ile Gly Ser Thr Tyr Ser Gly Leu Pro Asp Gly Gly 
        515                 520                 525             


Ser Gly Asn Pro Asn Pro Pro Val Ser Ser Ser Thr Pro Val Pro Ser 
    530                 535                 540                 


Ser Ser Thr Thr Ser Ser Gly Ser Ser Gly Pro Thr Gly Gly Thr Gly 
545                 550                 555                 560 


Val Ala Lys His Tyr Glu Gln Cys Gly Gly Gln Gly Phe Thr Gly Pro 
                565                 570                 575     


Thr Gln Cys Glu Ser Pro Tyr Thr Cys Thr Lys Leu Asn Asp Trp Tyr 
            580                 585                 590         


Ser Gln Cys Leu 
        595     


<210>  23
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide for M. thermophila CBH1a variant 473

<400>  23

Met Tyr Ala Lys Phe Ala Thr Leu Ala Ala Leu Val Ala Gly Ala Ala 
1               5                   10                  15      


Ala Gln Asn Ala Cys Thr Leu Thr Ala Glu Asn His Pro Ser Leu Thr 
            20                  25                  30          


Trp Ser Lys Cys Thr Ser Gly Gly Ser Cys Thr Ser Val Gln Gly Ser 
        35                  40                  45              


Ile Thr Ile Asp Ala Asn Trp Arg Trp Val His Arg Thr Asp Ser Ala 
    50                  55                  60                  


Thr Asn Cys Tyr Glu Gly Asn Lys Trp Asp Thr Ser Tyr Cys Ser Asp 
65                  70                  75                  80  


Gly Pro Ser Cys Ala Ser Lys Cys Cys Ile Asp Gly Ala Asp Tyr Ser 
                85                  90                  95      


Ser Thr Tyr Gly Ile Thr Thr Ser Gly Asn Ser Leu Asn Leu Lys Phe 
            100                 105                 110         


Val Thr Lys Gly Gln Tyr Ser Thr Asn Ile Gly Ser Arg Thr Tyr Leu 
        115                 120                 125             


Met Glu Ser Asp Thr Lys Tyr Gln Met Phe Gln Leu Leu Gly Asn Glu 
    130                 135                 140                 


Phe Thr Phe Asp Val Asp Val Ser Asn Leu Gly Cys Gly Leu Asn Gly 
145                 150                 155                 160 


Ala Leu Tyr Phe Val Ser Met Asp Ala Asp Gly Gly Met Ser Lys Tyr 
                165                 170                 175     


Ser Gly Asn Lys Ala Gly Ala Lys Tyr Gly Thr Gly Tyr Cys Asp Ser 
            180                 185                 190         


Gln Cys Pro Arg Asp Leu Lys Phe Ile Asn Gly Glu Ala Asn Val Glu 
        195                 200                 205             


Asn Trp Gln Ser Ser Thr Asn Asp Ala Asn Ala Gly Thr Gly Lys Tyr 
    210                 215                 220                 


Gly Ser Cys Cys Ser Glu Met Asp Val Trp Glu Ala Asn Asn Met Ala 
225                 230                 235                 240 


Ala Ala Phe Thr Pro His Pro Cys Thr Val Ile Gly Gln Ser Arg Cys 
                245                 250                 255     


Glu Gly Asp Ser Cys Gly Gly Thr Tyr Ser Thr Asp Arg Tyr Ala Gly 
            260                 265                 270         


Ile Cys Asp Pro Asp Gly Cys Asp Phe Asn Ser Tyr Arg Gln Gly Asn 
        275                 280                 285             


Lys Thr Phe Tyr Gly Lys Gly Met Thr Val Asp Thr Thr Lys Lys Ile 
    290                 295                 300                 


Thr Val Val Thr Gln Phe Leu Lys Asn Ser Ala Gly Glu Leu Ser Glu 
305                 310                 315                 320 


Ile Lys Arg Phe Tyr Val Gln Asn Gly Lys Val Ile Pro Asn Ser Glu 
                325                 330                 335     


Ser Thr Ile Pro Gly Val Glu Gly Asn Ser Ile Thr Gln Glu Tyr Cys 
            340                 345                 350         


Asp Arg Gln Lys Ala Ala Phe Gly Asp Val Asp Asp Phe Gln Asp Lys 
        355                 360                 365             


Gly Gly Met Val Gln Met Gly Lys Ala Leu Ala Gly Pro Met Val Leu 
    370                 375                 380                 


Val Met Ser Ile Trp Asp Asp His Ala Asp Asn Met Leu Trp Leu Asp 
385                 390                 395                 400 


Ser Thr Trp Pro Ile Asp Gly Ala Gly Lys Pro Gly Ala Glu Arg Gly 
                405                 410                 415     


Ala Cys Pro Thr Thr Ser Gly Val Pro Ala Glu Val Glu Ala Glu Ala 
            420                 425                 430         


Pro Asn Ser Asn Val Ile Phe Ser Asn Ile Arg Phe Gly Pro Ile Gly 
        435                 440                 445             


Ser Thr Tyr Ser Gly Leu Pro Asp Gly Gly Ser Gly Asn Pro Asn Pro 
    450                 455                 460                 


Pro Val Ser Ser Ser Thr Pro Val Pro Ser Ser Ser Thr Thr Ser Ser 
465                 470                 475                 480 


Gly Ser Ser Gly Pro Thr Gly Gly Thr Gly Val Ala Lys His Tyr Glu 
                485                 490                 495     


Gln Cys Gly Gly Gln Gly Phe Thr Gly Pro Thr Gln Cys Glu Ser Pro 
            500                 505                 510         


Tyr Thr Cys Thr Lys Leu Asn Asp Trp Tyr Ser Gln Cys Leu 
        515                 520                 525     


