                         SEQUENCE LISTING

<110>  ThromboGenics NV
 
<120>  ANTIBODIES ABROGATING CELL BINDING TO LACTADHERIN

<130>  TGX-007-PCT

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  1
atgggcagac ttacattctc attc                                              24


<210>  2
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  2
atggratgga gctgkatcwt thtc                                              24


<210>  3
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  3
casaymcagg ggccagtgga tagac                                             25


<210>  4
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  4
atggcctgga yttcacttat actctctctc ctg                                    33


<210>  5
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  5
atgaggkccc cwgctcagyt yytkggv                                           27


<210>  6
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  6
atggattttc aggtgcagat tttcag                                            26


<210>  7
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  7
agaggaaggt ggaaacaggg tgactgatgg                                        30


<210>  8
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  8
gctcactgga tggtgggaag atgg                                              24


<210>  9
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  9
gtaaaacgac ggccag                                                       16


<210>  10
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  synthetic nucleotide primer

<400>  10
caggaaacag ctatgac                                                      17


<210>  11
<211>  330
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(330)
<223>  light chain variable region - hybridoma 215A9

<400>  11
caggctgttg tgactcagga atctgcgctc accacatcac ccggtgaaac cgtaacactc       60

acttgtcgct caagcactgg tgctgtgacc actaacaatt atgccaactg ggtccaggag      120

aaaccggatc atctgtttac tgggctgata ggcgggacca acaatcgaac tcctggcgtt      180

ccagccaggt tctcagggtc cctgattgga gacaaggctg ccctcaccat cacaggcgca      240

cagactgagg atgaggcgat ctacttctgc gccctgtggt acagcaatct ttgggtgttt      300

ggaggtggca ccaaactgac tgtgctcgga                                       330


<210>  12
<211>  372
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(372)
<223>  heavy chain variable region - hybridoma 215A9

<400>  12
caggtttctc tgaaagagtc tggccctggg atattgcagt cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtgag ttggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actggaatga tgacaagcgc      180

tataacccat ccctgaagag tcgactcaca atctccaagg atacctctag agaccaggta      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca catacttctg tgctcgaaga      300

cctaggttct accgtgatta cgacgagggg attgacttct ggggccaagg caccactctc      360

acagtctcct ca                                                          372


<210>  13
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  light chain variable region - hybridoma 311A7

<400>  13
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgca gtgccagctc aagtgtaagt tacatgtact ggttccagca gaagccaggc      120

acttctccca aactctggat ttatagtaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttacc cacggacgtt cggtggaggc      300

accaagctgg aaatcaagcg g                                                321


<210>  14
<211>  363
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  heavy chain variable region - hybridoma 311A7

<400>  14
gagttccagc tgcagcagtc tggacctgaa ctggtgaagc ctggcgcttc agtgaggata       60

tcctgcaagg cttctggtta ctcattcact gactacaaca tgaactgggt gaagcagagc      120

gatggaaaga cccttgagtg gattggagtt attaatcctg actatggtac tactaacaac      180

aatcagaggt tcaggggcaa ggccacatta actctagacc tatcttccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagaggggga      300

gattacggcg cggggtatgc tttggattac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  15
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(321)
<223>  light chain variable region - hybridoma 346B6

<400>  15
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca gactcctgat ttatgacaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagttacc cacccacgtt cggtgctggg      300

accaagctgg agctgaaacg g                                                321


<210>  16
<211>  363
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(363)
<223>  heavy chain variable region - hybridoma 346B6

<400>  16
gagttccagc tgcagcagtc tggacctgaa ctggtgaagc ctggcgcttc agtgaggatt       60

tcctgcaagg cttctggtta ctcattcact gactacaaca tgaactgggt gaagcagagc      120

gatggaaaga cccttgagtg gattggagtt attaatcctg actatggtac tactaacaac      180

aatcagaggt tcaggggcaa ggccacatta actctagacc tatcttccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct attactgtgc aagagggggg      300

gattacggcg cggggtatgc tttggattac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  17
<211>  324
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(324)
<223>  light chain variable region - hybridoma 399A12

<400>  17
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcacttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaacta ttaaactcct gatctactac gcatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggaacaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgctcac gttcggtgct      300

gggaccaagc tggagctgaa acgg                                             324


<210>  18
<211>  375
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(375)
<223>  heavy chain variable region - hybridoma 399A12

<400>  18
caggtcactc tgaaagagtc tggccctggg gtcttgcagt cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggtt tgggtgtgat ctggattcgt      120

cagccttcag gagcgggtct ggagtggctg gcacaaattt actgggatga taacaagcgc      180

tataacccat ccctgaagag ccgcctcaca atctccaagg atacctccag aaaccaggta      240

ttcctcaaga tcacccctgt ggacactgca gatactgcca catactactg tgctcgaagg      300

accttctatg attacgacga aggtttctat gctatggact actggggtca aggaacctca      360

gtcaccgtct cctca                                                       375


<210>  19
<211>  110
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  light chain variable region - hybridoma 215A9

<400>  19

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Asn 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Thr Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  20
<211>  124
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(124)
<223>  heavy chain variable region - hybridoma 215A9

<400>  20

Gln Val Ser Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Ser Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg Asp Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Arg Pro Arg Phe Tyr Arg Asp Tyr Asp Glu Gly Ile Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 


<210>  21
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  light chain variable region - hybridoma 311A7

<400>  21

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  22
<211>  121
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(121)
<223>  heavy chain variable region - hybridoma 311A7

<400>  22

Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asp Gly Lys Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Asp Tyr Gly Thr Thr Asn Asn Asn Gln Arg Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Leu Asp Leu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Tyr Gly Ala Gly Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  light chain variable region - hybridoma 346B6

<400>  23

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  24
<211>  108
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  light chain variable region - hybridoma 399A12

<400>  24

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  25
<211>  125
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(125)
<223>  heavy chain variable region - hybridoma 399A12

<400>  25

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Val Leu Gln Ser Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ile Trp Ile Arg Gln Pro Ser Gly Ala Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Gln Ile Tyr Trp Asp Asp Asn Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Pro Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Thr Phe Tyr Asp Tyr Asp Glu Gly Phe Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  26
<211>  14
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  light chain variable region CDR1 - hybridoma 215A9

<400>  26

Arg Ser Ser Thr Gly Ala Val Thr Thr Asn Asn Tyr Ala Asn 
1               5                   10                  


<210>  27
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  light chain variable region CDR2 - hybridoma 215A9

<400>  27

Gly Thr Asn Asn Arg Thr Pro 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  light chain variable region CDR3 - hybridoma 215A9

<400>  28

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  29
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  light chain variable region CDR1 - hybridoma 399A12

<400>  29

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  30
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  light chain variable region CDR2 - hybridoma 399A12

<400>  30

Tyr Ala Ser Arg Leu His Ser 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  light chain variable region CDR3 - hybridoma 399A12

<400>  31

Gln Gln Gly Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  32
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  light chain variable region CDR1 - hybridoma 311A7

<400>  32

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  33
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  light chain variable region CDR2 - hybridoma 311A7

<400>  33

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  light chain variable region CDR3 - hybridoma 311A7

<400>  34

Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
1               5                   


<210>  35
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  light chain variable region CDR2 - hybridoma 346B6

<400>  35

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  light chain variable region CDR3 - hybridoma 346B6

<400>  36

Gln Gln Trp Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  37
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  light chain variable region CDR2 hybrid 311A7-346B6


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X at position 1 is Ser or Asp

<400>  37

Xaa Thr Ser Asn Leu Ala Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  light chain variable region CDR3 hybrid 311A7-346B6


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X at position 3 is Arg or Trp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X at position 8 is Arg or Pro

<400>  38

Gln Gln Xaa Ser Ser Tyr Pro Xaa Thr 
1               5                   


<210>  39
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  heavy chain variable region CDR1 - hybridoma 215A9

<400>  39

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  40
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  heavy chain variable region CDR2 - hybridoma 215A9

<400>  40

His Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  41
<211>  14
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  heavy chain variable region CDR3 - hybridoma 215A9

<400>  41

Arg Pro Arg Phe Tyr Arg Asp Tyr Asp Glu Gly Ile Asp Phe 
1               5                   10                  


<210>  42
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  heavy chain variable region CDR1 - hybridoma 399A12

<400>  42

Thr Ser Gly Leu Gly Val Ile 
1               5           


<210>  43
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  heavy chain variable region CDR2 - hybridoma 399A12

<400>  43

Ala Ile Tyr Trp Asp Asp Asn Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  44
<211>  15
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  heavy chain variable region CDR3 - hybridoma 399A12

<400>  44

Arg Thr Phe Tyr Asp Tyr Asp Glu Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  45
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain variable region CDR1 hybrid 215A9-399A12


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X at position 4 is Met or Leu

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X at position 4 is Ser or Ile

<400>  45

Thr Ser Gly Xaa Gly Val Xaa 
1               5           


<210>  46
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain variable region CDR2 hybrid 215A9-399A12


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X at position 1 is His or Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X at position 5 is Asn or Asp

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X at position 7 is Asn or Asp

<400>  46

Xaa Ile Tyr Trp Xaa Asp Xaa Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  47
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  heavy chain variable region CDR1 - hybridoma 311A7

<400>  47

Asp Tyr Asn Met Asn 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  heavy chain variable region CDR2 - hybridoma 311A7

<400>  48

Val Ile Asn Pro Asp Tyr Gly Thr Thr Asn Asn Asn Gln Arg Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  heavy chain variable region CDR3 - hybridoma 311A7

<400>  49

Gly Gly Asp Tyr Gly Ala Gly Tyr Ala Leu Asp Tyr 
1               5                   10          


<210>  50
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain variable region CDR3 hybrid 215A9-399A12


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X at position 3 is no amino acid or Arg

<400>  50

Phe Tyr Xaa Asp Tyr Asp Glu Gly 
1               5               


<210>  51
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing RGD motif

<400>  51

Glu Ile Ser Gln Glu Val Arg Gly Asp Val Phe Pro Ser Tyr 
1               5                   10                  


<210>  52
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 311A7

<400>  52

Glu Phe Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Pro Gly Gln Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Asp Tyr Gly Thr Thr Asn Asn Asn Gln Arg Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Leu Asp Leu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Tyr Gly Ala Gly Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  53
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 311A7

<400>  53

Glu Phe Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Pro Gly Gln Thr Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Asp Tyr Gly Thr Thr Asn Asn Asn Gln Arg Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Leu Asp Leu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Tyr Gly Ala Gly Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  54
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 311A7

<400>  54

Glu Phe Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Asp Tyr Gly Thr Thr Asn Asn Asn Gln Arg Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Leu Asp Leu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Tyr Gly Ala Gly Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  55
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 311A7

<400>  55

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  56
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 311A7

<400>  56

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  57
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 311A7

<400>  57

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  58
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 311A7

<400>  58
gaatttcagc tggtgcagtc tggcgccgag gtcgtgaaac ctggcgcctc cgtgaagatc       60

agctgcaagg ccagcggcta cagcttcacc gactacaaca tgaactgggt caagcagagc      120

cctggccaga ccctggaatg gatcggcgtg atcaaccccg actacggcac caccaacaac      180

aaccagcggt tccggggcaa ggccaccctg acactggatc tgagcaccag caccgcctac      240

atgcagctga acagcctgac cagcgaggac accgccgtgt actactgtgc cagaggcggc      300

gattacggcg ctggctacgc cctggattat tggggccagg gcacaagcgt gaccgtgtcc      360

tct                                                                    363


<210>  59
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 311A7

<400>  59
gaatttcagc tggtgcagtc tggcgccgag gtcgtgaaac ctggcgcctc cgtgaagatc       60

agctgcaagg ccagcggcta cagcttcacc gactacaaca tgaactgggt caagcagagc      120

cctggccaga ccctggaatg gatcggcgtg atcaaccccg actacggcac caccaacaac      180

aaccagcggt tccggggcaa ggccaccctg acactggatc tgagcaccag caccgcctac      240

atggaactga acagcctgac cagcgaggac accgccgtgt actactgtgc cagaggcggc      300

gattacggcg ctggctacgc cctggattat tggggccagg gcaccaccgt gaccgtgtct      360

agt                                                                    363


<210>  60
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 311A7

<400>  60
gaatttcagc tggtgcagtc tggcgccgag gtcgtgaaac ctggcgcctc cgtgaagatc       60

agctgcaagg ccagcggcta cagcttcacc gactacaaca tgaactgggt caagcagagc      120

ccaggccagg gcctggaatg gatcggcgtg atcaaccccg actacggcac caccaacaac      180

aaccagcggt tccggggcaa ggccaccctg acactggatc tgagcaccag caccgcctac      240

atggaactga acagcctgcg gagcgaggac accgccgtgt actattgtgc cagaggcggc      300

gactatggcg ccggatacgc cctggattat tggggccagg gcaccaccgt gaccgtgtct      360

agt                                                                    363


<210>  61
<211>  318
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 311A7

<400>  61
cagatcgtgc tgacccagag ccccgccaca atgagcgctt ctccaggcga gcgcgtgacc       60

atcacatgta gcgccagcag cagcgtgtcc tacatgtact ggttccagca gaagcccggc      120

accagcccca agctgtggat ctacagcacc agcaacctgg ccagcggcgt gccagccaga      180

ttttctggca gcggctctgg caccagctac agcctgacca tcagcagcat ggaacccgag      240

gacgccgcca cctactactg ccagcagaga agcagctacc cccggacctt tggcggaggc      300

accaagctgg aaatcaag                                                    318


<210>  62
<211>  318
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 311A7

<400>  62
cagatcgtgc tgacccagag ccccgccaca atgagcgctt ctccaggcga gagagtgacc       60

atcagctgca gcgccagcag cagcgtgtcc tacatgtact ggttccagca gaagcccggc      120

accagcccca agctgtggat ctacagcacc agcaacctgg ccagcggcgt gccagccaga      180

ttttctggca gcggctctgg caccagctac agcctgacca tctccagcat ggaacccgag      240

gacttcgcca cctactactg ccagcagcgg agcagctacc ccagaacctt tggcggaggc      300

accaagctgg aaatcaag                                                    318


<210>  63
<211>  318
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 311A7

<400>  63
cagatcgtgc tgacccagag ccccgccaca atgagcgctt ctccaggcga gagagtgacc       60

atcagctgca gcgccagcag cagcgtgtcc tacatgtact ggttccagca gaagcccggc      120

cagtccccca agctgtggat ctacagcacc agcaacctgg ccagcggcgt gccagccaga      180

ttttctggca gcggctctgg caccagctac agcctgacca tctccagcat ggaacccgag      240

gacttcgcca cctactactg ccagcagcgg agcagctacc ccagaacctt tggcggaggc      300

accaagctgg aaatcaag                                                    318


<210>  64
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 416H9

<400>  64

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Val Leu Gln Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ile Trp Ile Arg Gln Pro Ser Gly Ala Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Gln Ile Tyr Trp Asp Asp Asn Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Thr Ile Thr Pro Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Thr Phe Tyr Asp Tyr Asp Glu Gly Phe Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  65
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 416H9

<400>  65

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Val Leu Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ile Trp Ile Arg Gln Pro Ser Gly Ala Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Gln Ile Tyr Trp Asp Asp Asn Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Thr Ile Thr Pro Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Thr Phe Tyr Asp Tyr Asp Glu Gly Phe Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  66
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 416H9

<400>  66

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Val Leu Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ile Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Gln Ile Tyr Trp Asp Asp Asn Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Thr Ile Thr Pro Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Thr Phe Tyr Asp Tyr Asp Glu Gly Phe Tyr Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  67
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 416H9

<400>  67

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  68
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 416H9

<400>  68

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Ala Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  69
<211>  391
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 416H9

<400>  69
tgtacagtgt caagtgaccc tgaaagaaag cggccctggc gtgctgcagc ctacccagac       60

actgaccctg acctgcagct tcagcggctt cagcctgagc acatctggcc tgggcgtgat      120

ctggatcaga cagccttctg gcgccggact ggaatggctg gcccagatct actgggacga      180

caacaagcgg tacaacccca gcctgaagtc ccggctgacc atcaccaagg acaccagcaa      240

gaaccaggtg ttcctgacaa tcacccccgt ggacaccgcc gataccgcca cctactactg      300

tgccagacgg accttctacg actacgacga gggcttctac gccatggact actggggcca      360

gggcaccacc gtgaccgtgt catctgctag c                                     391


<210>  70
<211>  391
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 416H9

<400>  70
tgtacagtgt caagtgaccc tgaaagaaag cggccccacc gtgctgaagc ccacccagac       60

actgaccctg acctgcagct tcagcggctt cagcctgagc acatctggcc tgggcgtgat      120

ctggatcaga cagccttctg gcgccggact ggaatggctg gcccagatct actgggacga      180

caacaagcgg tacaacccca gcctgaagtc ccggctgacc atcaccaagg acaccagcaa      240

gaaccaggtg ttcctgacaa tcacccccgt ggacaccgcc gataccgcca cctactactg      300

tgccagacgg accttctacg actacgacga gggcttctac gccatggact actggggcca      360

gggcaccacc gtgaccgtgt catctgctag c                                     391


<210>  71
<211>  391
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized heavy chain of murine antibody 416H9

<400>  71
tgtacagtgt caagtgaccc tgaaagaaag cggccccacc gtgctgaagc ccacccagac       60

actgaccctg acctgcagct tcagcggctt cagcctgagc acatctggcc tgggcgtgat      120

ctggatcaga cagcctcctg gcaagggcct ggaatggctg gcccagatct actgggacga      180

caacaagcgg tacaacccca gcctgaagtc ccggctgacc atcaccaagg acaccagcaa      240

gaaccaggtg ttcctgacaa tcacccccgt ggacaccgcc gataccgcca cctactactg      300

cgccagacgg accttctacg actacgacga gggcttctac gccatggact actggggcca      360

gggcaccacc gtgaccgtgt catctgctag c                                     391


<210>  72
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 416H9

<400>  72
tctagatgcg acatccagat gacccagacc accagcagcc tgagcgccag cgtgggcgac       60

agagtgacca tcacctgtag agccagccag gacatcagca actacctgaa ctggtatcag      120

cagaagcctg gcggcaccat caagctgctg atctactacg ccagcagact gcacagcggc      180

gtgcccagca gattttctgg cagcggctcc ggcaccgact acagcctgac aatcagctcc      240

ctggaacccg aggatatcgc tacctacttc tgtcagcaag gcaacaccct gcccctgacc      300

tttggagccg gcaccaagct ggaaatcaag cgtacg                                336


<210>  73
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  humanized light chain of murine antibody 416H9

<400>  73
tctagatgcg acatccagat gacccagacc accagcagcc tgagcgccag cgtgggcgac       60

agagtgacca tcacctgtag agccagccag gacatcagca actacctgaa ctggtatcag      120

cagaagcctg gcggagccat caagctgctg atctactacg ccagcagact gcacagcggc      180

gtgcccagca gattttctgg cagcggctcc ggcaccgact acagcctgac aatcagctcc      240

ctggaacccg aggatatcgc tacctacttc tgtcagcaag gcaacaccct gcccctgacc      300

tttggccagg gcaccaagct ggaaatcaag cgtacg                                336


<210>  74
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  74

Glu Ile Ser Gln Glu Val Ala Gly Asp Val Phe Pro Ser Tyr 
1               5                   10                  


<210>  75
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  75

Glu Ile Ser Gln Glu Val Arg Ala Asp Val Phe Pro Ser Tyr 
1               5                   10                  


<210>  76
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  76

Glu Ile Ser Gln Glu Val Arg Gly Ala Val Phe Pro Ser Tyr 
1               5                   10                  


<210>  77
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  77

Glu Ile Ser Gln Glu Val Ala Ala Asp Val Phe Pro Ser Tyr 
1               5                   10                  


<210>  78
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  78

Glu Ile Ser Gln Glu Val Arg Ala Ala Val Phe Pro Ser Tyr 
1               5                   10                  


<210>  79
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  79

Glu Ile Ser Gln Glu Val Ala Gly Ala Val Phe Pro Ser Tyr 
1               5                   10                  


<210>  80
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  80

Glu Ile Ser Gln Glu Val Ala Ala Ala Val Phe Pro Ser Tyr 
1               5                   10                  


<210>  81
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  81

Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg Gly 
1               5                   10                  


<210>  82
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  82

His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val Arg 
1               5                   10                  


<210>  83
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide located N-terminal of RGD motif

<400>  83

Cys His Asn Gly Gly Leu Cys Glu Glu Ile Ser Gln Glu Val 
1               5                   10                  


<210>  84
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  84

Gly Asp Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly 
1               5                   10                  


<210>  85
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide containing mutated RGD motif

<400>  85

Asp Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr 
1               5                   10                  


<210>  86
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  synthetic lactadherin peptide located C-terminal of RGD motif

<400>  86

Val Phe Pro Ser Tyr Thr Cys Thr Cys Leu Lys Gly Tyr Ala 
1               5                   10                  


<210>  87
<211>  135
<212>  PRT
<213>  Mus musculus

<400>  87

Thr Gly Leu Val Cys Asn Glu Thr Glu Arg Gly Pro Cys Ser Pro Asn 
1               5                   10                  15      


Pro Cys Tyr Asn Asp Ala Lys Cys Leu Val Thr Leu Asp Thr Gln Arg 
            20                  25                  30          


Gly Asp Ile Phe Thr Glu Tyr Ile Cys Gln Cys Pro Val Gly Tyr Ser 
        35                  40                  45              


Gly Ile His Cys Glu Thr Glu Thr Asn Tyr Tyr Asn Leu Asp Gly Glu 
    50                  55                  60                  


Tyr Met Phe Thr Thr Ala Val Pro Asn Thr Ala Val Pro Thr Pro Ala 
65                  70                  75                  80  


Pro Thr Pro Asp Leu Ser Asn Asn Leu Ala Ser Arg Cys Ser Thr Gln 
                85                  90                  95      


Leu Gly Met Glu Gly Gly Ala Ile Ala Asp Ser Gln Ile Ser Ala Ser 
            100                 105                 110         


Ser Val Tyr Met Gly Phe Met Gly Leu Gln Arg Trp Gly Pro Glu Leu 
        115                 120                 125             


Ala Arg Leu Tyr Arg Thr Gly 
    130                 135 


