SEQUENCE LISTING

<110>  DUCHATEAU PHILIPPE
       VALTON JULIEN
       CELLECTIS
		
 
<120>  METHOD TO OVERCOME DNA CHEMICAL MODIFICATIONS SENSITIVITY OF 
ENGINEERED TALE DNA BINDING DOMAINS	

<130>  413114WO 

<160>  57   

<170>  PatentIn version 3.5


<210>  1

<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  xpc1 locus

<400>  1
tccgagatgt cacacagagg tacgacccag tctggatgac agtga                     45


<210>  2

<211>  1590
<212>  DNA
<213>  artificial sequence

<220>
<223>  XPCT1L_HD

<400>  2
ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag     60
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg    120
gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg    180
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat    240
aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc    300
cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg    360
ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt gaccccccag    420
caggtggtgg ccatcgccag caataatggt ggcaagcagg cgctggagac ggtccagcgg    480
ctgttgccgg tgctgtgcca ggcccacggc ttgaccccgg agcaggtggt ggccatcgcc    540
agcaatattg gtggcaagca ggcgctggag acggtgcagg cgctgttgcc ggtgctgtgc    600
caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg cggtggcaag    660
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc    720
ccccagcagg tggtggccat cgccagcaat aatggtggca agcaggcgct ggagacggtc    780
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc    840
atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg    900
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc    960
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   1020
ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag   1080
acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg   1140
gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg   1200
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat   1260
attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc   1320
cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg   1380
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1440
caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg   1500
ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc   1560
agcaatggcg gcggcaggcc ggcgctggag                                    1590


<210>  3

<211>  1587
<212>  DNA
<213>  artificial sequence

<220>
<223>  XPCT1L_N*

<400>  3
ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag     60
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg    120
gtggccatcg ccagcaatgg tggcaagcag gcgctggaga cggtccagcg gctgttgccg    180
gtgctgtgcc aggcccacgg cttgaccccc cagcaggtgg tggccatcgc cagcaataat    240
ggtggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg ccaggcccac    300
ggcttgaccc cggagcaggt ggtggccatc gccagcaata ttggtggcaa gcaggcgctg    360
gagacggtgc aggcgctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag    420
gtggtggcca tcgccagcaa taatggtggc aagcaggcgc tggagacggt ccagcggctg    480
ttgccggtgc tgtgccaggc ccacggcttg accccggagc aggtggtggc catcgccagc    540
aatattggtg gcaagcaggc gctggagacg gtgcaggcgc tgttgccggt gctgtgccag    600
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaatggcgg tggcaagcag    660
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc    720
cagcaggtgg tggccatcgc cagcaataat ggtggcaagc aggcgctgga gacggtccag    780
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc    840
gccagcaatg gcggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg    900
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcca cgatggcggc    960
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1020
accccggagc aggtggtggc catcgccagc aatattggtg gcaagcaggc gctggagacg   1080
gtgcaggcgc tgttgccggt gctgtgccag gcccacggct tgaccccgga gcaggtggtg   1140
gccatcgcca gccacgatgg cggcaagcag gcgctggaga cggtccagcg gctgttgccg   1200
gtgctgtgcc aggcccacgg cttgaccccg gagcaggtgg tggccatcgc cagcaatatt   1260
ggtggcaagc aggcgctgga gacggtgcag gcgctgttgc cggtgctgtg ccaggcccac   1320
ggcttgaccc cggagcaggt ggtggccatc gccagccacg atggcggcaa gcaggcgctg   1380
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccggagcag   1440
gtggtggcca tcgccagcaa tattggtggc aagcaggcgc tggagacggt gcaggcgctg   1500
ttgccggtgc tgtgccaggc ccacggcttg acccctcagc aggtggtggc catcgccagc   1560
aatggcggcg gcaggccggc gctggag                                       1587


<210>  4

<211>  1590
<212>  DNA
<213>  artificial sequence

<220>
<223>  XPCT1R

<400>  4
ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag     60
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg    120
gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg    180
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagccac    240
gatggcggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc    300
cacggcttga ccccccagca ggtggtggcc atcgccagca atggcggtgg caagcaggcg    360
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccccag    420
caggtggtgg ccatcgccag caataatggt ggcaagcagg cgctggagac ggtccagcgg    480
ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc    540
agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc    600
caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagccacga tggcggcaag    660
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc    720
ccggagcagg tggtggccat cgccagcaat attggtggca agcaggcgct ggagacggtg    780
caggcgctgt tgccggtgct gtgccaggcc cacggcttga ccccccagca ggtggtggcc    840
atcgccagca atggcggtgg caagcaggcg ctggagacgg tccagcggct gttgccggtg    900
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc    960
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   1020
ttgaccccgg agcaggtggt ggccatcgcc agccacgatg gcggcaagca ggcgctggag   1080
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg   1140
gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg   1200
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat   1260
aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc   1320
cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg   1380
ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1440
caggtggtgg ccatcgccag ccacgatggc ggcaagcagg cgctggagac ggtccagcgg   1500
ctgttgccgg tgctgtgcca ggcccacggc ttgacccctc agcaggtggt ggccatcgcc   1560
agcaatggcg gcggcaggcc ggcgctggag                                    1590


<210>  5

<211>  170
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALE Repeat HD

<400>  5
ggccggacgg gccgacgtcc gcagcgacat gttgaccccg gagcaggtgg tggccatcgc     60
cagccacgat ggcggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg    120
ccaggcccac ggcttgaccc tcgagatgcg gtaccggggc cactggggcc               170


<210>  6

<211>  170
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALE Repeat NI

<400>  6
ggccggacgg gccgacgtcc gcagcgacat gttgaccccg gagcaggtgg tggccatcgc     60
cagcaatatt ggtggcaagc aggcgctgga gacggtgcag gcgctgttgc cggtgctgtg    120
ccaggcccac ggcttgaccc tcgagatgcg gtaccggggc cactggggcc               170


<210>  7

<211>  170
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALE Repeat NN

<400>  7
ggccggacgg gccgacgtcc gcagcgacat gttgaccccc cagcaggtgg tggccatcgc     60
cagcaataat ggtggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg    120
ccaggcccac ggcttgaccc tcgagatgcg gtaccggggc cactggggcc               170


<210>  8

<211>  170
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALE Repeat HG

<400>  8
ggccggacgg gccgacgtcc gcagcgacat gttgaccccg gagcaggtgg tggccatcgc     60
cagccacggc ggcggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg    120
ccaggcccac ggcttgaccc tcgagatgcg gtaccggggc cactggggcc               170


<210>  9

<211>  167
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALE Repeat N*

<400>  9
ggccggacgg gccgacgtcc gcagcgacat gttgaccccg gagcaggtgg tggccatcgc     60
cagcaatggt ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca    120
ggcccacggc ttgaccctcg agatgcggta ccggggccac tggggcc                  167


<210>  10

<211>  1584
<212>  DNA
<213>  artificial sequence

<220>
<223>  pCLS7802

<400>  10
atggccgacc ccattcgttc gcgcacacca agtcctgccc gcgagcttct gcccggaccc     60
caacccgatg gggttcagcc gactgcagat cgtggggtgt ctccgcctgc cggcggcccc    120
ctggatggct tgccggctcg gcggacgatg tcccggaccc ggctgccatc tccccctgcc    180
ccctcacctg cgttctcggc gggcagcttc agtgacctgt tacgtcagtt cgatccgtca    240
ctttttaata catcgctttt tgattcattg cctcccttcg gcgctcacca tacagaggct    300
gccacaggcg agtgggatga ggtgcaatcg ggtctgcggg cagccgacgc ccccccaccc    360
accatgcgcg tggctgtcac tgccgcgcgg cccccgcgcg ccaagccggc gccgcgacga    420
cgtgctgcgc aaccctccga cgcttcgccg gcggcgcagg tggatctacg cacgctcggc    480
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    540
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    600
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    660
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    720
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    780
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    840
aatgcactga cgggtgcccc gctcaacttg accggagacg cccgggggat caggtcacgt    900
gcgtctcgga gcattgttgc ccagttatct cgccctgatc cgagtggcag cggaagtggc    960
ggggatccta tcagccgttc ccagctggtg aagtccgagc tggaggagaa gaaatccgag   1020
ttgaggcaca agctgaagta cgtgccccac gagtacatcg agctgatcga gatcgcccgg   1080
aacagcaccc aggaccgtat cctggagatg aaggtgatgg agttcttcat gaaggtgtac   1140
ggctacaggg gcaagcacct gggcggctcc aggaagcccg acggcgccat ctacaccgtg   1200
ggctccccca tcgactacgg cgtgatcgtg gacaccaagg cctactccgg cggctacaac   1260
ctgcccatcg gccaggccga cgaaatgcag aggtacgtgg aggagaacca gaccaggaac   1320
aagcacatca accccaacga gtggtggaag gtgtacccct ccagcgtgac cgagttcaag   1380
ttcctgttcg tgtccggcca cttcaagggc aactacaagg cccagctgac caggctgaac   1440
cacatcacca actgcaacgg cgccgtgctg tccgtggagg agctcctgat cggcggcgag   1500
atgatcaagg ccggcaccct gaccctggag gaggtgagga ggaagttcaa caacggcgag   1560
atcaacttcg cggccgactg ataa                                          1584


<210>  11

<211>  1653
<212>  DNA
<213>  artificial sequence

<220>
<223>  pCLS11170

<400>  11
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacttga ccggagacgc ccgggggatc    960
aggtcacgtg cgtctcggag cattgttgcc cagttatctc gccctgatcc gagtggcagc   1020
ggaagtggcg gggatcctat cagccgttcc cagctggtga agtccgagct ggaggagaag   1080
aaatccgagt tgaggcacaa gctgaagtac gtgccccacg agtacatcga gctgatcgag   1140
atcgcccgga acagcaccca ggaccgtatc ctggagatga aggtgatgga gttcttcatg   1200
aaggtgtacg gctacagggg caagcacctg ggcggctcca ggaagcccga cggcgccatc   1260
tacaccgtgg gctcccccat cgactacggc gtgatcgtgg acaccaaggc ctactccggc   1320
ggctacaacc tgcccatcgg ccaggccgac gaaatgcaga ggtacgtgga ggagaaccag   1380
accaggaaca agcacatcaa ccccaacgag tggtggaagg tgtacccctc cagcgtgacc   1440
gagttcaagt tcctgttcgt gtccggccac ttcaagggca actacaaggc ccagctgacc   1500
aggctgaacc acatcaccaa ctgcaacggc gccgtgctgt ccgtggagga gctcctgatc   1560
ggcggcgaga tgatcaaggc cggcaccctg accctggagg aggtgaggag gaagttcaac   1620
aacggcgaga tcaacttcgc ggccgactga taa                                1653


<210>  12

<211>  62
<212>  DNA
<213>  artificial sequence

<220>
<223>  XPCMID1_F

<400>  12
ccatctcatc cctgcgtgtc tccgactcag acgagtgcgt aagaggcaag aaaatgtgca     60
gc                                                                    62


<210>  13

<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<223>  XPC_R

<400>  13
cctatcccct gtgtgccttg gcagtctcag gctgggcata tataaggtgc tcaa           54


<210>  14

<211>  530
<212>  PRT
<213>  artificial sequence

<220>
<223>  XPCT1L_HD

<400>  14
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
65                  70                  75                  80  


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        515                 520                 525             


Leu Glu 
    530 


<210>  15

<211>  529
<212>  PRT
<213>  artificial sequence

<220>
<223>  XPCT1L_N*

<400>  15
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        35                  40                  45              


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    50                  55                  60                  


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
65                  70                  75                  80  


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                85                  90                  95      


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            100                 105                 110         


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
        115                 120                 125             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    130                 135                 140                 


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
145                 150                 155                 160 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                165                 170                 175     


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            180                 185                 190         


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
        195                 200                 205             


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
    210                 215                 220                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
225                 230                 235                 240 


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
                245                 250                 255     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            260                 265                 270         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        275                 280                 285             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    290                 295                 300                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
305                 310                 315                 320 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                325                 330                 335     


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
            340                 345                 350         


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
        355                 360                 365             


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
    370                 375                 380                 


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
385                 390                 395                 400 


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
                405                 410                 415     


Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu 
            420                 425                 430         


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
        435                 440                 445             


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
    450                 455                 460                 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
465                 470                 475                 480 


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
                485                 490                 495     


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
            500                 505                 510         


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu 
        515                 520                 525             


Glu 
    


<210>  16

<211>  530
<212>  PRT
<213>  artificial sequence

<220>
<223>  XPCT1R

<400>  16
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
65                  70                  75                  80  


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
            340                 345                 350         


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        515                 520                 525             


Leu Glu 
    530 


<210>  17

<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALE Repeat HD

<400>  17
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly 
        


<210>  18

<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALE Repeat NI

<400>  18
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly 
        


<210>  19

<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALE Repeat NN

<400>  19
Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly 
        


<210>  20

<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALE Repeat HG

<400>  20
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Gly Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly 
        


<210>  21

<211>  33
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALE Repeat N*

<400>  21
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Lys Gln 
1               5                   10                  15      


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            20                  25                  30          


Gly 
    


<210>  22

<211>  526
<212>  PRT
<213>  artificial sequence

<220>
<223>  pCLS7802

<400>  22
Met Ala Asp Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu 
1               5                   10                  15      


Leu Pro Gly Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly 
            20                  25                  30          


Val Ser Pro Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg 
        35                  40                  45              


Thr Met Ser Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala 
    50                  55                  60                  


Phe Ser Ala Gly Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser 
65                  70                  75                  80  


Leu Phe Asn Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His 
                85                  90                  95      


His Thr Glu Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu 
            100                 105                 110         


Arg Ala Ala Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala 
        115                 120                 125             


Ala Arg Pro Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln 
    130                 135                 140                 


Pro Ser Asp Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly 
145                 150                 155                 160 


Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr 
                165                 170                 175     


Val Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala 
            180                 185                 190         


His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala 
        195                 200                 205             


Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu 
    210                 215                 220                 


Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu 
225                 230                 235                 240 


Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu 
                245                 250                 255     


Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala 
            260                 265                 270         


Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu 
        275                 280                 285             


Asn Leu Thr Gly Asp Ala Arg Gly Ile Arg Ser Arg Ala Ser Arg Ser 
    290                 295                 300                 


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Gly Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu 
                325                 330                 335     


Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr 
            340                 345                 350         


Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu 
        355                 360                 365             


Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly 
    370                 375                 380                 


Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val 
385                 390                 395                 400 


Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser 
                405                 410                 415     


Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr 
            420                 425                 430         


Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp 
        435                 440                 445             


Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val 
    450                 455                 460                 


Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn 
465                 470                 475                 480 


His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu 
                485                 490                 495     


Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val 
            500                 505                 510         


Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        515                 520                 525     


<210>  23

<211>  549
<212>  PRT
<213>  artificial sequence

<220>
<223>  pCLS11170

<400>  23
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Gly Asp Ala Arg Gly Ile 
305                 310                 315                 320 


Arg Ser Arg Ala Ser Arg Ser Ile Val Ala Gln Leu Ser Arg Pro Asp 
                325                 330                 335     


Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser Arg Ser Gln Leu 
            340                 345                 350         


Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu 
        355                 360                 365             


Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn 
    370                 375                 380                 


Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met 
385                 390                 395                 400 


Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro 
                405                 410                 415     


Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile 
            420                 425                 430         


Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln 
        435                 440                 445             


Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys 
    450                 455                 460                 


His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr 
465                 470                 475                 480 


Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys 
                485                 490                 495     


Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val 
            500                 505                 510         


Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly 
        515                 520                 525             


Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile 
    530                 535                 540                 


Asn Phe Ala Ala Asp 
545                 


<210>  24

<211>  8334
<212>  DNA
<213>  artificial sequence

<220>
<223>  pCLS0542

<400>  24
tgtgtgcggc cgactgataa ctcgagcgat cctctagacg agctcctcga gcctgcagca     60
gctgaagctt tggacttctt cgccagaggt ttggtcaagt ctccaatcaa ggttgtcggc    120
ttgtctacct tgccagaaat ttacgaaaag atggaaaagg gtcaaatcgt tggtagatac    180
gttgttgaca cttctaaata agcgaatttc ttatgattta tgatttttat tattaaataa    240
gttataaaaa aaataagtgt atacaaattt taaagtgact cttaggtttt aaaacgaaaa    300
ttcttattct tgagtaactc tttcctgtag gtcaggttgc tttctcaggt atagcatgag    360
gtcgctctta ttgaccacac ctctaccggc atgcaagctt ggcgtaatca tggtcatagc    420
tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca    480
taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct    540
cactgcccgc tttccagtcg ggaaacctgt cgtgccagca gatctattac attatgggtg    600
gtatgttgga ataaaaatca actatcatct actaactagt atttacgtta ctagtatatt    660
atcatatacg gtgttagaag atgacgcaaa tgatgagaaa tagtcatcta aattagtgga    720
agctgaaacg caaggattga taatgtaata ggatcaatga atattaacat ataaaatgat    780
gataataata tttatagaat tgtgtagaat tgcagattcc cttttatgga ttcctaaatc    840
ctcgaggaga acttctagta tatctacata cctaatatta ttgccttatt aaaaatggaa    900
tcccaacaat tacatcaaaa tccacattct cttcaaaatc aattgtcctg tacttccttg    960
ttcatgtgtg ttcaaaaacg ttatatttat aggataatta tactctattt ctcaacaagt   1020
aattggttgt ttggccgagc ggtctaaggc gcctgattca agaaatatct tgaccgcagt   1080
taactgtggg aatactcagg tatcgtaaga tgcaagagtt cgaatctctt agcaaccatt   1140
atttttttcc tcaacataac gagaacacac aggggcgcta tcgcacagaa tcaaattcga   1200
tgactggaaa ttttttgtta atttcagagg tcgcctgacg catatacctt tttcaactga   1260
aaaattggga gaaaaaggaa aggtgagagc cgcggaaccg gcttttcata tagaatagag   1320
aagcgttcat gactaaatgc ttgcatcaca atacttgaag ttgacaatat tatttaagga   1380
cctattgttt tttccaatag gtggttagca atcgtcttac tttctaactt ttcttacctt   1440
ttacatttca gcaatatata tatatatatt tcaaggatat accattctaa tgtctgcccc   1500
taagaagatc gtcgttttgc caggtgacca cgttggtcaa gaaatcacag ccgaagccat   1560
taaggttctt aaagctattt ctgatgttcg ttccaatgtc aagttcgatt tcgaaaatca   1620
tttaattggt ggtgctgcta tcgatgctac aggtgtccca cttccagatg aggcgctgga   1680
agcctccaag aaggttgatg ccgttttgtt aggtgctgtg ggtggtccta aatggggtac   1740
cggtagtgtt agacctgaac aaggtttact aaaaatccgt aaagaacttc aattgtacgc   1800
caacttaaga ccatgtaact ttgcatccga ctctctttta gacttatctc caatcaagcc   1860
acaatttgct aaaggtactg acttcgttgt tgtcagagaa ttagtgggag gtatttactt   1920
tggtaagaga aaggaagacg atggtgatgg tgtcgcttgg gatagtgaac aatacaccgt   1980
tccagaagtg caaagaatca caagaatggc cgctttcatg gccctacaac atgagccacc   2040
attgcctatt tggtccttgg ataaagctaa tgttttggcc tcttcaagat tatggagaaa   2100
aactgtggag gaaaccatca agaacgaatt ccctacattg aaggttcaac atcaattgat   2160
tgattctgcc gccatgatcc tagttaagaa cccaacccac ctaaatggta ttataatcac   2220
cagcaacatg tttggtgata tcatctccga tgaagcctcc gttatcccag gttccttggg   2280
tttgttgcca tctgcgtcct tggcctcttt gccagacaag aacaccgcat ttggtttgta   2340
cgaaccatgc cacggttctg ctccagattt gccaaagaat aaggtcaacc ctatcgccac   2400
tatcttgtct gctgcaatga tgttgaaatt gtcattgaac ttgcctgaag aaggtaaggc   2460
cattgaagat gcagttaaaa aggttttgga tgcaggtatc agaactggtg atttaggtgg   2520
ttccaacagt accacggaag tcggtgatgc tgtcgccgaa gaagttaaga aaatccttgc   2580
ttaaaaagat tctctttttt tatgatattt gtacataaac tttataaatg aaattcataa   2640
tagaaacgac acgaaattac aaaatggaat atgttcatag ggtagacgaa actatatacg   2700
caatctacat acatttatca agaaggagaa aaaggaggat gtaaaggaat acaggtaagc   2760
aaattgatac taatggctca acgtgataag gaaaaagaat tgcactttaa cattaatatt   2820
gacaaggagg agggcaccac acaaaaagtt aggtgtaaca gaaaatcatg aaactatgat   2880
tcctaattta tatattggag gattttctct aaaaaaaaaa aaatacaaca aataaaaaac   2940
actcaatgac ctgaccattt gatggagttt aagtcaatac cttcttgaac catttcccat   3000
aatggtgaaa gttccctcaa gaattttact ctgtcagaaa cggccttaac gacgtagtcg   3060
acctcctctt cagtactaaa tctaccaata ccaaatctga tggaagaatg ggctaatgca   3120
tcatccttac ccagcgcatg taaaacataa gaaggttcta gggaagcaga tgtacaggct   3180
gaacccgagg ataatgcgat atcccttagt gccatcaata aagattctcc ttccacgtag   3240
gcgaaagaaa cgttaacaca ccctggataa cgatgatctg gagatccgtt caacgtggta   3300
tgttcagcgg ataatagacc tttgactaat ttatcggata gtcttttgat gtgagcttgg   3360
tcgttgtcaa attctttctt catcaatctc gcagcttcac caaatcccgc taccaatggg   3420
ggggccaaag taccagatct gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt   3480
ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg   3540
ctgcggcgag cggtatcagc atcgatgaat tccacggact atagactata ctagtatact   3600
ccgtctactg tacgatacac ttccgctcag gtccttgtcc tttaacgagg ccttaccact   3660
cttttgttac tctattgatc cagctcagca aaggcagtgt gatctaagat tctatcttcg   3720
cgatgtagta aaactagcta gaccgagaaa gagactagaa atgcaaaagg cacttctaca   3780
atggctgcca tcattattat ccgatgtgac gctgcagctt ctcaatgata ttcgaatacg   3840
ctttgaggag atacagccta atatccgaca aactgtttta cagatttacg atcgtacttg   3900
ttacccatca ttgaattttg aacatccgaa cctgggagtt ttccctgaaa cagatagtat   3960
atttgaacct gtataataat atatagtcta gcgctttacg gaagacaatg tatgtatttc   4020
ggttcctgga gaaactattg catctattgc ataggtaatc ttgcacgtcg catccccggt   4080
tcattttctg cgtttccatc ttgcacttca atagcatatc tttgttaacg aagcatctgt   4140
gcttcatttt gtagaacaaa aatgcaacgc gagagcgcta atttttcaaa caaagaatct   4200
gagctgcatt tttacagaac agaaatgcaa cgcgaaagcg ctattttacc aacgaagaat   4260
ctgtgcttca tttttgtaaa acaaaaatgc aacgcgagag cgctaatttt tcaaacaaag   4320
aatctgagct gcatttttac agaacagaaa tgcaacgcga gagcgctatt ttaccaacaa   4380
agaatctata cttctttttt gttctacaaa aatgcatccc gagagcgcta tttttctaac   4440
aaagcatctt agattacttt ttttctcctt tgtgcgctct ataatgcagt ctcttgataa   4500
ctttttgcac tgtaggtccg ttaaggttag aagaaggcta ctttggtgtc tattttctct   4560
tccataaaaa aagcctgact ccacttcccg cgtttactga ttactagcga agctgcgggt   4620
gcattttttc aagataaagg catccccgat tatattctat accgatgtgg attgcgcata   4680
ctttgtgaac agaaagtgat agcgttgatg attcttcatt ggtcagaaaa ttatgaacgg   4740
tttcttctat tttgtctcta tatactacgt ataggaaatg tttacatttt cgtattgttt   4800
tcgattcact ctatgaatag ttcttactac aatttttttg tctaaagagt aatactagag   4860
ataaacataa aaaatgtaga ggtcgagttt agatgcaagt tcaaggagcg aaaggtggat   4920
gggtaggtta tatagggata tagcacagag atatatagca aagagatact tttgagcaat   4980
gtttgtggaa gcggtattcg caatatttta gtagctcgtt acagtccggt gcgtttttgg   5040
ttttttgaaa gtgcgtcttc agagcgcttt tggttttcaa aagcgctctg aagttcctat   5100
actttctaga gaataggaac ttcggaatag gaacttcaaa gcgtttccga aaacgagcgc   5160
ttccgaaaat gcaacgcgag ctgcgcacat acagctcact gttcacgtcg cacctatatc   5220
tgcgtgttgc ctgtatatat atatacatga gaagaacggc atagtgcgtg tttatgctta   5280
aatgcgtact tatatgcgtc tatttatgta ggatgaaagg tagtctagta cctcctgtga   5340
tattatccca ttccatgcgg ggtatcgtat gcttccttca gcactaccct ttagctgttc   5400
tatatgctgc cactcctcaa ttggattagt ctcatccttc aatgctatca tttcctttga   5460
tattggatca tatgcatagt accgagaaac tagtgcgaag tagtgatcag gtattgctgt   5520
tatctgatga gtatacgttg tcctggccac ggcagaagca cgcttatcgc tccaatttcc   5580
cacaacatta gtcaactccg ttaggccctt cattgaaaga aatgaggtca tcaaatgtct   5640
tccaatgtga gattttgggc cattttttat agcaaagatt gaataaggcg catttttctt   5700
caaagcttta ttgtacgatc tgactaagtt atcttttaat aattggtatt cctgtttatt   5760
gcttgaagaa ttgccggtcc tatttactcg ttttaggact ggttcagaat tcatcgatgc   5820
tcactcaaag gtcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca   5880
tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt   5940
tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc   6000
gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct   6060
ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg   6120
tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca   6180
agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact   6240
atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta   6300
acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta   6360
actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct   6420
tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt   6480
tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga   6540
tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca   6600
tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat   6660
caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg   6720
cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt   6780
agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag   6840
acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc   6900
gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag   6960
ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca   7020
tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa   7080
ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga   7140
tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata   7200
attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca   7260
agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg   7320
ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg   7380
ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg   7440
cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag   7500
gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac   7560
tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca   7620
tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag   7680
tgccacctga cgtccgatca aaaatcatcg cttcgctgat taattacccc agaaataagg   7740
ctaaaaaact aatcgcatta tcatcctatg gttgttaatt tgattcgttc atttgaaggt   7800
ttgtggggcc aggttactgc caatttttcc tcttcataac cataaaagct agtattgtag   7860
aatctttatt gttcggagca gtgcggcgcg aggcacatct gcgtttcagg aacgcgaccg   7920
gtgaagacga ggacgcacgg aggagagtct tccttcggag ggctgtcacc cgctcggcgg   7980
cttctaatcc gtacttcaat atagcaatga gcagttaagc gtattactga aagttccaaa   8040
gagaaggttt ttttaggcta atcgacctcg agcagatccg ccaggcgtgt atatagcgtg   8100
gatggccagg caactttagt gctgacacat acaggcatat atatatgtgt gcgacgacac   8160
atgatcatat ggcatgcatg tgctctgtat gtatataaaa ctcttgtttt cttcttttct   8220
ctaaatattc tttccttata cattaggtcc tttgtagcat aaattactat acttctatag   8280
acacgcaaac acaaatacac agcggccttg ccaccatggc cggcgcgccc acta         8334


<210>  25

<211>  4905
<212>  DNA
<213>  artificial sequence

<220>
<223>  pCLS8391

<400>  25
gtttgtttaa acttggtacc ataactagtt cggcgcgcca ctagcgctgt cacgcgtctc     60
catggacagc tagcaatgat atcttcttaa ttaagaccta ggaaagcggc cgcggagctc    120
caggaattct gcagatcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc    180
cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag    240
gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag    300
gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct    360
atggatcctc tagagtcgac ctgcaggcat gcaagcttgg cgtaatcatg gtcatagctg    420
tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata    480
aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca    540
ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc    600
gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg    660
cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta    720
tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc    780
aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag    840
catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac    900
caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc    960
ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt   1020
aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc   1080
gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga   1140
cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta   1200
ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta   1260
tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga   1320
tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg   1380
cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag   1440
tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc   1500
tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact   1560
tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt   1620
cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta   1680
ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta   1740
tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc   1800
gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat   1860
agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt   1920
atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg   1980
tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca   2040
gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta   2100
agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg   2160
cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact   2220
ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg   2280
ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt   2340
actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga   2400
ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc   2460
atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa   2520
caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt   2580
attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg tctcgcgcgt   2640
ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt   2700
ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg   2760
tgtcggggct ggcttaacta tgcggcatca gagcagattg tactgagagt gcaccatatg   2820
cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg ccattcgcca   2880
ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg cctcttcgct attacgccag   2940
ctggcgaaag ggggatgtgc tgcaaggcga ttaagttggg taacgccagg gttttcccag   3000
tcacgacgtt gtaaaacgac ggccagtgaa ttcgcgccaa agctaactgt aggactgagt   3060
ctattctaaa ctgaaagcct ggacatctgg agtaccaggg ggagatgacg tgttacgggc   3120
ttccataaaa gcagctggct ttgaatggaa ggagccaaga ggccagcaca ggagcggatt   3180
cgtcgctttc acggccatcg agccgaacct ctcgcaagtc cgtgagccgt taaggaggcc   3240
cccagtcccg acccttcgcc ccaagcccct cggggtcccc gggcctggta ctccttgcca   3300
cacgggaggg gcgcggaagc cggggcggag gaggagccaa ccccgggctg ggctgagacc   3360
cgcagaggaa gacgctctag ggatttgtcc cggactagcg agatggcaag gctgaggacg   3420
ggaggctgat tgagaggcga aggtacaccc taatctcaat acaacctttg gagctaagcc   3480
agcaatggta gagggaagat tctgcacgtc ccttccaggc ggcctccccg tcaccacccc   3540
ccccaacccg ccccgaccgg agctgagagt aattcataca aaaggactcg cccctgcctt   3600
ggggaatccc agggaccgtc gttaaactcc cactaacgta gaacccagag atcgctgcgt   3660
tcccgccccc tcacccgccc gctctcgtca tcactgaggt ggagaagagc atgcgtgagg   3720
ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca gtccccgaga agttgggggg   3780
aggggtcggc aattgaaccg gtgcctagag aaggtggcgc ggggtaaact gggaaagtga   3840
tgtcgtgtac tggctccgcc tttttcccga gggtggggga gaaccgtata taagtgcagt   3900
agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt   3960
gtgtggttcc cgcgggcctg gcctctttac gggttatggc ccttgcgtgc cttgaattac   4020
ttccacgccc ctggctgcag tacgtgattc ttgatcccga gcttcgggtt ggaagtgggt   4080
gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga gttgaggcct   4140
ggcttgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc tgtctcgctg   4200
ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg ctttttttct   4260
ggcaagatag tcttgtaaat gcgggccaag atcgatctgc acactggtat ttcggttttt   4320
ggggccgcgg gcggcgacgg ggcccgtgcg tcccagcgca catgttcggc gaggcggggc   4380
ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc aagctggccg gcctgctctg   4440
gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg cggcaaggct ggcccggtcg   4500
gcaccagttg cgtgagcgga aagatggccg cttcccggcc ctgctgcagg gagctcaaaa   4560
tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac ccacacaaag gaaaagggcc   4620
tttccgtcct cagccgtcgc ttcatgtgac tccacggagt accgggcgcc gtccaggcac   4680
ctcgattagt tctcgagctt ttggagtacg tcgtctttag gttgggggga ggggttttat   4740
gcgatggagt ttccccacac tgagtgggtg gagactgaag ttaggccagc ttggcacttg   4800
atgtaattct ccttggaatt tgcccttttt gagtttggat cttggttcat tctcaagcct   4860
cagacagtgg ttcaaagttt ttttcttcca tttcaggtgt cgtgg                   4905


<210>  26

<211>  3201
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-HD

<400>  26
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacttga ccccggagca ggtggtggcc    960
atcgccagcc acgatggcgg caagcaggcg ctggagacgg tccagcggct gttgccggtg   1020
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc   1080
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   1140
ttgacccccc agcaggtggt ggccatcgcc agcaataatg gtggcaagca ggcgctggag   1200
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg   1260
gtggccatcg ccagcaatat tggtggcaag caggcgctgg agacggtgca ggcgctgttg   1320
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat   1380
aatggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc   1440
cacggcttga ccccggagca ggtggtggcc atcgccagca atattggtgg caagcaggcg   1500
ctggagacgg tgcaggcgct gttgccggtg ctgtgccagg cccacggctt gaccccccag   1560
caggtggtgg ccatcgccag caatggcggt ggcaagcagg cgctggagac ggtccagcgg   1620
ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc   1680
agcaataatg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc   1740
caggcccacg gcttgacccc ccagcaggtg gtggccatcg ccagcaatgg cggtggcaag   1800
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc   1860
ccggagcagg tggtggccat cgccagccac gatggcggca agcaggcgct ggagacggtc   1920
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc   1980
atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg   2040
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc   2100
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   2160
ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag   2220
acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg   2280
gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg   2340
ccggtgctgt gccaggccca cggcttgacc ccggagcagg tggtggccat cgccagcaat   2400
attggtggca agcaggcgct ggagacggtg caggcgctgt tgccggtgct gtgccaggcc   2460
cacggcttga cccctcagca ggtggtggcc atcgccagca atggcggcgg caggccggcg   2520
ctggagagca ttgttgccca gttatctcgc cctgatccga gtggcagcgg aagtggcggg   2580
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2640
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2700
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2760
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2820
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2880
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2940
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   3000
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   3060
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   3120
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   3180
aacttcgcgg ccgactgata a                                             3201


<210>  27

<211>  3198
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-N*

<400>  27
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacttga ccccggagca ggtggtggcc    960
atcgccagcc acgatggcgg caagcaggcg ctggagacgg tccagcggct gttgccggtg   1020
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag caatggcggc   1080
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1140
accccccagc aggtggtggc catcgccagc aataatggtg gcaagcaggc gctggagacg   1200
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgaccccgga gcaggtggtg   1260
gccatcgcca gcaatattgg tggcaagcag gcgctggaga cggtgcaggc gctgttgccg   1320
gtgctgtgcc aggcccacgg cttgaccccc cagcaggtgg tggccatcgc cagcaataat   1380
ggtggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg ccaggcccac   1440
ggcttgaccc cggagcaggt ggtggccatc gccagcaata ttggtggcaa gcaggcgctg   1500
gagacggtgc aggcgctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag   1560
gtggtggcca tcgccagcaa tggcggtggc aagcaggcgc tggagacggt ccagcggctg   1620
ttgccggtgc tgtgccaggc ccacggcttg accccccagc aggtggtggc catcgccagc   1680
aataatggtg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag   1740
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaatggcgg tggcaagcag   1800
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccg   1860
gagcaggtgg tggccatcgc cagccacgat ggcggcaagc aggcgctgga gacggtccag   1920
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc   1980
gccagcaata ttggtggcaa gcaggcgctg gagacggtgc aggcgctgtt gccggtgctg   2040
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcca cgatggcggc   2100
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   2160
accccggagc aggtggtggc catcgccagc aatattggtg gcaagcaggc gctggagacg   2220
gtgcaggcgc tgttgccggt gctgtgccag gcccacggct tgaccccgga gcaggtggtg   2280
gccatcgcca gccacgatgg cggcaagcag gcgctggaga cggtccagcg gctgttgccg   2340
gtgctgtgcc aggcccacgg cttgaccccg gagcaggtgg tggccatcgc cagcaatatt   2400
ggtggcaagc aggcgctgga gacggtgcag gcgctgttgc cggtgctgtg ccaggcccac   2460
ggcttgaccc ctcagcaggt ggtggccatc gccagcaatg gcggcggcag gccggcgctg   2520
gagagcattg ttgcccagtt atctcgccct gatccgagtg gcagcggaag tggcggggat   2580
cctatcagcc gttcccagct ggtgaagtcc gagctggagg agaagaaatc cgagttgagg   2640
cacaagctga agtacgtgcc ccacgagtac atcgagctga tcgagatcgc ccggaacagc   2700
acccaggacc gtatcctgga gatgaaggtg atggagttct tcatgaaggt gtacggctac   2760
aggggcaagc acctgggcgg ctccaggaag cccgacggcg ccatctacac cgtgggctcc   2820
cccatcgact acggcgtgat cgtggacacc aaggcctact ccggcggcta caacctgccc   2880
atcggccagg ccgacgaaat gcagaggtac gtggaggaga accagaccag gaacaagcac   2940
atcaacccca acgagtggtg gaaggtgtac ccctccagcg tgaccgagtt caagttcctg   3000
ttcgtgtccg gccacttcaa gggcaactac aaggcccagc tgaccaggct gaaccacatc   3060
accaactgca acggcgccgt gctgtccgtg gaggagctcc tgatcggcgg cgagatgatc   3120
aaggccggca ccctgaccct ggaggaggtg aggaggaagt tcaacaacgg cgagatcaac   3180
ttcgcggccg actgataa                                                 3198


<210>  28

<211>  3201
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-NG

<400>  28
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacctga ccccagaaca ggtggtggct    960
atcgcctcac acgatggggg aaaacaggcc ctggagacag tgcagcggct gctccctgtg   1020
ctttgccagg ctcacggact gacccccgag caggtggtcg caatcgccag taacgggggc   1080
ggaaaacaag ccctggaaac agtccagcgc ctcctgcctg tgctgtgtca ggcccacggc   1140
ttgaccccac agcaggtcgt cgccattgct tccaacaatg gcggaaagca ggctctggag   1200
actgtgcaga gactgctccc cgtgctgtgc caggcacacg ggctgacacc tgagcaagtg   1260
gtcgccatcg caagcaacat tggcggcaag caagcccttg agacagtcca agctctgctg   1320
ccagtgcttt gtcaggctca tgggctcacc ccccagcaag tcgtggccat tgcctctaac   1380
aacggcggga agcaggcctt ggagaccgtc cagagactcc tgcccgtgct ctgccaagca   1440
catgggttga ctccagaaca ggtggtcgca attgccagta acatcggcgg gaagcaagcg   1500
ttggaaactg tgcaagctct cctccccgtg ctgtgtcagg cacacggcct cacacctcaa   1560
caagtcgtgg caatcgcctc caacgggggg gggaagcagg ccctggagac agtccagagg   1620
ttgctgcccg tcctttgcca ggcccacggc ctgaccccac aacaagtggt ggctatcgca   1680
agtaacaatg gcgggaaaca agccctcgag acagtgcagc ggctcttgcc tgtcttgtgt   1740
caagcccacg gactgactcc ccaacaggtc gtggccatcg cctctaacgg cgggggcaag   1800
caagcactcg agactgtcca gcgcctcctg cccgtgcttt gccaagctca cggccttacc   1860
cctgagcaag tggtcgctat tgccagccat gatggcggaa agcaagccct ggaaaccgtg   1920
cagaggctgc tgccagtgct gtgccaggct catgggctga cacccgagca ggtggtggcc   1980
attgcctcaa atattggagg gaaacaggcc ttggagactg tgcaggcact cctcccagtg   2040
ctgtgtcagg ctcatggcct gactcccgag caagtcgtgg ccatcgcaag ccacgacggg   2100
gggaagcaag cactggagac cgtccagaga ctgctgcccg tgctctgtca agctcacgga   2160
ctgacaccag aacaggtggt cgccattgct tccaacattg gcggcaagca agccctggag   2220
acagtgcaag ctctcctgcc tgtgttgtgc caggctcacg gcctgacccc tgagcaggtc   2280
gtggcaatcg cctcccatga cgggggaaaa caggccctcg agaccgtgca gaggctgctt   2340
cctgtccttt gccaggccca cggcctcaca cccgaacagg tcgtcgctat tgccagcaat   2400
atcgggggca agcaggctct cgagacagtc caggccttgc tcccagtgct gtgccaagcc   2460
cacgggctta ctccacagca ggtggtggct atcgccagca acgggggagg gcggccagct   2520
ctggagagca ttgttgccca gttatctcgc cctgatccga gtggcagcgg aagtggcggg   2580
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2640
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2700
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2760
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2820
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2880
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2940
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   3000
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   3060
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   3120
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   3180
aacttcgcgg ccgactgata a                                             3201


<210>  29

<211>  3198
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-H*

<400>  29
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacctga ccccagaaca ggtggtggct    960
atcgcctcac acgatggggg aaaacaggcc ctggagacag tgcagcggct gctccctgtg   1020
ctttgccagg ctcacggact gacccccgag caggtggtcg caatcgccag tcacgggggc   1080
aaacaagccc tggaaacagt ccagcgcctc ctgcctgtgc tgtgtcaggc ccacggcttg   1140
accccacagc aggtcgtcgc cattgcttcc aacaatggcg gaaagcaggc tctggagact   1200
gtgcagagac tgctccccgt gctgtgccag gcacacgggc tgacacctga gcaagtggtc   1260
gccatcgcaa gcaacattgg cggcaagcaa gcccttgaga cagtccaagc tctgctgcca   1320
gtgctttgtc aggctcatgg gctcaccccc cagcaagtcg tggccattgc ctctaacaac   1380
ggcgggaagc aggccttgga gaccgtccag agactcctgc ccgtgctctg ccaagcacat   1440
gggttgactc cagaacaggt ggtcgcaatt gccagtaaca tcggcgggaa gcaagcgttg   1500
gaaactgtgc aagctctcct ccccgtgctg tgtcaggcac acggcctcac acctcaacaa   1560
gtcgtggcaa tcgcctccaa cggggggggg aagcaggccc tggagacagt ccagaggttg   1620
ctgcccgtcc tttgccaggc ccacggcctg accccacaac aagtggtggc tatcgcaagt   1680
aacaatggcg ggaaacaagc cctcgagaca gtgcagcggc tcttgcctgt cttgtgtcaa   1740
gcccacggac tgactcccca acaggtcgtg gccatcgcct ctaacggcgg gggcaagcaa   1800
gcactcgaga ctgtccagcg cctcctgccc gtgctttgcc aagctcacgg ccttacccct   1860
gagcaagtgg tcgctattgc cagccatgat ggcggaaagc aagccctgga aaccgtgcag   1920
aggctgctgc cagtgctgtg ccaggctcat gggctgacac ccgagcaggt ggtggccatt   1980
gcctcaaata ttggagggaa acaggccttg gagactgtgc aggcactcct cccagtgctg   2040
tgtcaggctc atggcctgac tcccgagcaa gtcgtggcca tcgcaagcca cgacgggggg   2100
aagcaagcac tggagaccgt ccagagactg ctgcccgtgc tctgtcaagc tcacggactg   2160
acaccagaac aggtggtcgc cattgcttcc aacattggcg gcaagcaagc cctggagaca   2220
gtgcaagctc tcctgcctgt gttgtgccag gctcacggcc tgacccctga gcaggtcgtg   2280
gcaatcgcct cccatgacgg gggaaaacag gccctcgaga ccgtgcagag gctgcttcct   2340
gtcctttgcc aggcccacgg cctcacaccc gaacaggtcg tcgctattgc cagcaatatc   2400
gggggcaagc aggctctcga gacagtccag gccttgctcc cagtgctgtg ccaagcccac   2460
gggcttactc cacagcaggt ggtggctatc gccagcaacg ggggagggcg gccagctctg   2520
gagagcattg ttgcccagtt atctcgccct gatccgagtg gcagcggaag tggcggggat   2580
cctatcagcc gttcccagct ggtgaagtcc gagctggagg agaagaaatc cgagttgagg   2640
cacaagctga agtacgtgcc ccacgagtac atcgagctga tcgagatcgc ccggaacagc   2700
acccaggacc gtatcctgga gatgaaggtg atggagttct tcatgaaggt gtacggctac   2760
aggggcaagc acctgggcgg ctccaggaag cccgacggcg ccatctacac cgtgggctcc   2820
cccatcgact acggcgtgat cgtggacacc aaggcctact ccggcggcta caacctgccc   2880
atcggccagg ccgacgaaat gcagaggtac gtggaggaga accagaccag gaacaagcac   2940
atcaacccca acgagtggtg gaaggtgtac ccctccagcg tgaccgagtt caagttcctg   3000
ttcgtgtccg gccacttcaa gggcaactac aaggcccagc tgaccaggct gaaccacatc   3060
accaactgca acggcgccgt gctgtccgtg gaggagctcc tgatcggcgg cgagatgatc   3120
aaggccggca ccctgaccct ggaggaggtg aggaggaagt tcaacaacgg cgagatcaac   3180
ttcgcggccg actgataa                                                 3198


<210>  30

<211>  3219
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT1R

<400>  30
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc     60
gagagacagc acatggacag catcgatatc gccgacccca ttcgttcgcg cacaccaagt    120
cctgcccgcg agcttctgcc cggaccccaa cccgatgggg ttcagccgac tgcagatcgt    180
ggggtgtctc cgcctgccgg cggccccctg gatggcttgc cggctcggcg gacgatgtcc    240
cggacccggc tgccatctcc ccctgccccc tcacctgcgt tctcggcggg cagcttcagt    300
gacctgttac gtcagttcga tccgtcactt tttaatacat cgctttttga ttcattgcct    360
cccttcggcg ctcaccatac agaggctgcc acaggcgagt gggatgaggt gcaatcgggt    420
ctgcgggcag ccgacgcccc cccacccacc atgcgcgtgg ctgtcactgc cgcgcggccc    480
ccgcgcgcca agccggcgcc gcgacgacgt gctgcgcaac cctccgacgc ttcgccggcg    540
gcgcaggtgg atctacgcac gctcggctac agccagcagc aacaggagaa gatcaaaccg    600
aaggttcgtt cgacagtggc gcagcaccac gaggcactgg tcggccacgg gtttacacac    660
gcgcacatcg ttgcgttaag ccaacacccg gcagcgttag ggaccgtcgc tgtcaagtat    720
caggacatga tcgcagcgtt gccagaggcg acacacgaag cgatcgttgg cgtcggcaaa    780
cagtggtccg gcgcacgcgc tctggaggcc ttgctcacgg tggcgggaga gttgagaggt    840
ccaccgttac agttggacac aggccaactt ctcaagattg caaaacgtgg cggcgtgacc    900
gcagtggagg cagtgcatgc atggcgcaat gcactgacgg gtgccccgct caacttgacc    960
ccggagcagg tggtggccat cgccagccac gatggcggca agcaggcgct ggagacggtc   1020
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc   1080
atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg   1140
ctgtgccagg cccacggctt gaccccggag caggtggtgg ccatcgccag ccacgatggc   1200
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   1260
ttgacccccc agcaggtggt ggccatcgcc agcaatggcg gtggcaagca ggcgctggag   1320
acggtccagc ggctgttgcc ggtgctgtgc caggcccacg gcttgacccc ccagcaggtg   1380
gtggccatcg ccagcaataa tggtggcaag caggcgctgg agacggtcca gcggctgttg   1440
ccggtgctgt gccaggccca cggcttgacc ccccagcagg tggtggccat cgccagcaat   1500
ggcggtggca agcaggcgct ggagacggtc cagcggctgt tgccggtgct gtgccaggcc   1560
cacggcttga ccccggagca ggtggtggcc atcgccagcc acgatggcgg caagcaggcg   1620
ctggagacgg tccagcggct gttgccggtg ctgtgccagg cccacggctt gaccccggag   1680
caggtggtgg ccatcgccag caatattggt ggcaagcagg cgctggagac ggtgcaggcg   1740
ctgttgccgg tgctgtgcca ggcccacggc ttgacccccc agcaggtggt ggccatcgcc   1800
agcaatggcg gtggcaagca ggcgctggag acggtccagc ggctgttgcc ggtgctgtgc   1860
caggcccacg gcttgacccc ggagcaggtg gtggccatcg ccagccacga tggcggcaag   1920
caggcgctgg agacggtcca gcggctgttg ccggtgctgt gccaggccca cggcttgacc   1980
ccggagcagg tggtggccat cgccagccac gatggcggca agcaggcgct ggagacggtc   2040
cagcggctgt tgccggtgct gtgccaggcc cacggcttga ccccggagca ggtggtggcc   2100
atcgccagca atattggtgg caagcaggcg ctggagacgg tgcaggcgct gttgccggtg   2160
ctgtgccagg cccacggctt gaccccccag caggtggtgg ccatcgccag caataatggt   2220
ggcaagcagg cgctggagac ggtccagcgg ctgttgccgg tgctgtgcca ggcccacggc   2280
ttgaccccgg agcaggtggt ggccatcgcc agcaatattg gtggcaagca ggcgctggag   2340
acggtgcagg cgctgttgcc ggtgctgtgc caggcccacg gcttgacccc ggagcaggtg   2400
gtggccatcg ccagccacga tggcggcaag caggcgctgg agacggtcca gcggctgttg   2460
ccggtgctgt gccaggccca cggcttgacc cctcagcagg tggtggccat cgccagcaat   2520
ggcggcggca ggccggcgct ggagagcatt gttgcccagt tatctcgccc tgatccgagt   2580
ggcagcggaa gtggcgggga tcctatcagc cgttcccagc tggtgaagtc cgagctggag   2640
gagaagaaat ccgagttgag gcacaagctg aagtacgtgc cccacgagta catcgagctg   2700
atcgagatcg cccggaacag cacccaggac cgtatcctgg agatgaaggt gatggagttc   2760
ttcatgaagg tgtacggcta caggggcaag cacctgggcg gctccaggaa gcccgacggc   2820
gccatctaca ccgtgggctc ccccatcgac tacggcgtga tcgtggacac caaggcctac   2880
tccggcggct acaacctgcc catcggccag gccgacgaaa tgcagaggta cgtggaggag   2940
aaccagacca ggaacaagca catcaacccc aacgagtggt ggaaggtgta cccctccagc   3000
gtgaccgagt tcaagttcct gttcgtgtcc ggccacttca agggcaacta caaggcccag   3060
ctgaccaggc tgaaccacat caccaactgc aacggcgccg tgctgtccgt ggaggagctc   3120
ctgatcggcg gcgagatgat caaggccggc accctgaccc tggaggaggt gaggaggaag   3180
ttcaacaacg gcgagatcaa cttcgcggcc gactgataa                          3219


<210>  31

<211>  3201
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT2L-HD

<400>  31
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacctga ccccacaaca ggtggtggct    960
atcgcctcaa ataacggggg aaaacaggcc ctggagacag tgcagcggct gctccctgtg   1020
ctttgccagg ctcacggact gaccccccag caggtggtcg caatcgccag taacaacggc   1080
ggaaaacaag ccctggaaac agtccagcgc ctcctgcctg tgctgtgtca ggcccacggc   1140
ttgaccccac agcaggtcgt cgccattgct tccaacaatg gcggaaagca ggctctggag   1200
actgtgcaga gactgctccc cgtgctgtgc caggcacacg ggctgacacc tcagcaagtg   1260
gtcgccatcg caagcaacgg gggcggcaag caagcccttg agacagtcca acggctgctg   1320
ccagtgcttt gtcaggctca tgggctcacc cccgagcaag tcgtggccat tgcctctcac   1380
gatggcggga agcaggcctt ggagaccgtc cagagactcc tgcccgtgct ctgccaagca   1440
catgggttga ctccagaaca ggtggtcgca attgccagtc atgatggcgg gaagcaagcg   1500
ttggaaactg tgcaaagact cctccccgtg ctgtgtcagg cacacggcct cacacctcaa   1560
caagtcgtgg caatcgcctc caacaatggg gggaagcagg ccctggagac agtccagagg   1620
ttgctgcccg tcctttgcca ggcccacggc ctgaccccag aacaagtggt ggctatcgca   1680
agtaacatcg gcgggaaaca agccctcgag acagtgcagg ctctcttgcc tgtcttgtgt   1740
caagcccacg gactgactcc ccaacaggtc gtggccatcg cctctaacaa cgggggcaag   1800
caagcactcg agactgtcca gcgcctcctg cccgtgcttt gccaagctca cggccttacc   1860
cctgagcaag tggtcgctat tgccagcaac attggcggaa agcaagccct ggaaaccgtg   1920
caggcactgc tgccagtgct gtgccaggct catgggctga caccccagca ggtggtggcc   1980
attgcctcaa atggcggagg gaaacaggcc ttggagactg tgcagaggct cctcccagtg   2040
ctgtgtcagg ctcatggcct gactccccag caagtcgtgg ccatcgcaag caataacggg   2100
gggaagcaag cactggagac cgtccagaga ctgctgcccg tgctctgtca agctcacgga   2160
ctgacaccac aacaggtggt cgccattgct tccaacggcg gcggcaagca agccctggag   2220
acagtgcaaa gactcctgcc tgtgttgtgc caggctcacg gcctgacccc tgagcaggtc   2280
gtggcaatcg cctcccatga cgggggaaaa caggccctcg agaccgtgca gaggctgctt   2340
cctgtccttt gccaggccca cggcctcaca cccgaacagg tcgtcgctat tgccagcaat   2400
atcgggggca agcaggctct cgagacagtc caggccttgc tcccagtgct gtgccaagcc   2460
cacgggctta ctccacagca ggtggtggct atcgccagca acgggggagg gcggccagct   2520
ctggagagca ttgttgccca gttatctcgc cctgatccga gtggcagcgg aagtggcggg   2580
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2640
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2700
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2760
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2820
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2880
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2940
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   3000
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   3060
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   3120
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   3180
aacttcgcgg ccgactgata a                                             3201


<210>  32

<211>  3198
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT2L-N*

<400>  32
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacctga ccccacaaca ggtggtggct    960
atcgcctcaa ataacggggg aaaacaggcc ctggagacag tgcagcggct gctccctgtg   1020
ctttgccagg ctcacggact gaccccccag caggtggtcg caatcgccag taacaacggc   1080
ggaaaacaag ccctggaaac agtccagcgc ctcctgcctg tgctgtgtca ggcccacggc   1140
ttgaccccac agcaggtcgt cgccattgct tccaacaatg gcggaaagca ggctctggag   1200
actgtgcaga gactgctccc cgtgctgtgc caggcacacg ggctgacacc tcagcaagtg   1260
gtcgccatcg caagcaacgg gggcggcaag caagcccttg agacagtcca acggctgctg   1320
ccagtgcttt gtcaggctca tgggctcacc cccgagcaag tcgtggccat tgcctctcac   1380
gatggcggga agcaggcctt ggagaccgtc cagagactcc tgcccgtgct ctgccaagca   1440
catgggttga ctccagaaca ggtggtcgca attgccagta atggcgggaa gcaagcgttg   1500
gaaactgtgc aaagactcct ccccgtgctg tgtcaggcac acggcctcac acctcaacaa   1560
gtcgtggcaa tcgcctccaa caatgggggg aagcaggccc tggagacagt ccagaggttg   1620
ctgcccgtcc tttgccaggc ccacggcctg accccagaac aagtggtggc tatcgcaagt   1680
aacatcggcg ggaaacaagc cctcgagaca gtgcaggctc tcttgcctgt cttgtgtcaa   1740
gcccacggac tgactcccca acaggtcgtg gccatcgcct ctaacaacgg gggcaagcaa   1800
gcactcgaga ctgtccagcg cctcctgccc gtgctttgcc aagctcacgg ccttacccct   1860
gagcaagtgg tcgctattgc cagcaacatt ggcggaaagc aagccctgga aaccgtgcag   1920
gcactgctgc cagtgctgtg ccaggctcat gggctgacac cccagcaggt ggtggccatt   1980
gcctcaaatg gcggagggaa acaggccttg gagactgtgc agaggctcct cccagtgctg   2040
tgtcaggctc atggcctgac tccccagcaa gtcgtggcca tcgcaagcaa taacgggggg   2100
aagcaagcac tggagaccgt ccagagactg ctgcccgtgc tctgtcaagc tcacggactg   2160
acaccacaac aggtggtcgc cattgcttcc aacggcggcg gcaagcaagc cctggagaca   2220
gtgcaaagac tcctgcctgt gttgtgccag gctcacggcc tgacccctga gcaggtcgtg   2280
gcaatcgcct cccatgacgg gggaaaacag gccctcgaga ccgtgcagag gctgcttcct   2340
gtcctttgcc aggcccacgg cctcacaccc gaacaggtcg tcgctattgc cagcaatatc   2400
gggggcaagc aggctctcga gacagtccag gccttgctcc cagtgctgtg ccaagcccac   2460
gggcttactc cacagcaggt ggtggctatc gccagcaacg ggggagggcg gccagctctg   2520
gagagcattg ttgcccagtt atctcgccct gatccgagtg gcagcggaag tggcggggat   2580
cctatcagcc gttcccagct ggtgaagtcc gagctggagg agaagaaatc cgagttgagg   2640
cacaagctga agtacgtgcc ccacgagtac atcgagctga tcgagatcgc ccggaacagc   2700
acccaggacc gtatcctgga gatgaaggtg atggagttct tcatgaaggt gtacggctac   2760
aggggcaagc acctgggcgg ctccaggaag cccgacggcg ccatctacac cgtgggctcc   2820
cccatcgact acggcgtgat cgtggacacc aaggcctact ccggcggcta caacctgccc   2880
atcggccagg ccgacgaaat gcagaggtac gtggaggaga accagaccag gaacaagcac   2940
atcaacccca acgagtggtg gaaggtgtac ccctccagcg tgaccgagtt caagttcctg   3000
ttcgtgtccg gccacttcaa gggcaactac aaggcccagc tgaccaggct gaaccacatc   3060
accaactgca acggcgccgt gctgtccgtg gaggagctcc tgatcggcgg cgagatgatc   3120
aaggccggca ccctgaccct ggaggaggtg aggaggaagt tcaacaacgg cgagatcaac   3180
ttcgcggccg actgataa                                                 3198


<210>  33

<211>  3219
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT2R

<400>  33
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc     60
gagagacagc acatggacag catcgatatc gccgacccca ttcgttcgcg cacaccaagt    120
cctgcccgcg agcttctgcc cggaccccaa cccgatgggg ttcagccgac tgcagatcgt    180
ggggtgtctc cgcctgccgg cggccccctg gatggcttgc cggctcggcg gacgatgtcc    240
cggacccggc tgccatctcc ccctgccccc tcacctgcgt tctcggcggg cagcttcagt    300
gacctgttac gtcagttcga tccgtcactt tttaatacat cgctttttga ttcattgcct    360
cccttcggcg ctcaccatac agaggctgcc acaggcgagt gggatgaggt gcaatcgggt    420
ctgcgggcag ccgacgcccc cccacccacc atgcgcgtgg ctgtcactgc cgcgcggccc    480
ccgcgcgcca agccggcgcc gcgacgacgt gctgcgcaac cctccgacgc ttcgccggcg    540
gcgcaggtgg atctacgcac gctcggctac agccagcagc aacaggagaa gatcaaaccg    600
aaggttcgtt cgacagtggc gcagcaccac gaggcactgg tcggccacgg gtttacacac    660
gcgcacatcg ttgcgttaag ccaacacccg gcagcgttag ggaccgtcgc tgtcaagtat    720
caggacatga tcgcagcgtt gccagaggcg acacacgaag cgatcgttgg cgtcggcaaa    780
cagtggtccg gcgcacgcgc tctggaggcc ttgctcacgg tggcgggaga gttgagaggt    840
ccaccgttac agttggacac aggccaactt ctcaagattg caaaacgtgg cggcgtgacc    900
gcagtggagg cagtgcatgc atggcgcaat gcactgacgg gtgccccgct caacctgacc    960
ccacaacagg tggtggctat cgcctcaaat aacgggggaa aacaggccct ggagacagtg   1020
cagcggctgc tccctgtgct ttgccaggct cacggactga ccccccagca ggtggtcgca   1080
atcgccagta acggaggcgg aaaacaagcc ctggaaacag tccagcgcct cctgcctgtg   1140
ctgtgtcagg cccacggctt gaccccagag caggtcgtcg ccattgcttc ccacgatggc   1200
ggaaagcagg ctctggagac tgtgcagaga ctgctccccg tgctgtgcca ggcacacggg   1260
ctgacacctg agcaagtggt cgccatcgca agcaacattg gcggcaagca agcccttgag   1320
acagtccaag ctctgctgcc agtgctttgt caggctcatg ggctcacccc ccaacaagtc   1380
gtggccattg cctctaacgg cggcgggaag caggccttgg agaccgtcca gagactcctg   1440
cccgtgctct gccaagcaca tgggttgact ccagaacagg tggtcgcaat tgccagtcat   1500
gatggcggga agcaagcgtt ggaaactgtg caaagactcc tccccgtgct gtgtcaggca   1560
cacggcctca cacctgaaca agtcgtggca atcgcctccc atgacggggg gaagcaggcc   1620
ctggagacag tccagaggtt gctgcccgtc ctttgccagg cccacggcct gaccccagaa   1680
caagtggtgg ctatcgcaag taacatcggc gggaaacaag ccctcgagac agtgcaggct   1740
ctcttgcctg tcttgtgtca agcccacgga ctgactcccc aacaggtcgt ggccatcgcc   1800
tctaacaacg ggggcaagca agcactcgag actgtccagc gcctcctgcc cgtgctttgc   1860
caagctcacg gccttacccc tgagcaagtg gtcgctattg ccagcaacat tggcggaaag   1920
caagccctgg aaaccgtgca ggcactgctg ccagtgctgt gccaggctca tgggctgaca   1980
cccgagcagg tggtggccat tgcctcacat gatggaggga aacaggcctt ggagactgtg   2040
cagaggctcc tcccagtgct gtgtcaggct catggcctga ctccccagca agtcgtggcc   2100
atcgcaagca acggaggggg gaagcaagca ctggagaccg tccagagact gctgcccgtg   2160
ctctgtcaag ctcacggact gacaccacaa caggtggtcg ccattgcttc caacaacggc   2220
ggcaagcaag ccctggagac agtgcaaaga ctcctgcctg tgttgtgcca ggctcacggc   2280
ctgacccctc aacaggtcgt ggcaatcgcc tccaataatg ggggaaaaca ggccctcgag   2340
accgtgcaga ggctgcttcc tgtcctttgc caggcccacg gcctcacacc ccagcaggtc   2400
gtcgctattg ccagcaataa cgggggcaag caggctctcg agacagtcca gaggttgctc   2460
ccagtgctgt gccaagccca cgggcttact ccacagcagg tggtggctat cgccagcaac   2520
gggggagggc ggccagctct ggagagcatt gttgcccagt tatctcgccc tgatccgagt   2580
ggcagcggaa gtggcgggga tcctatcagc cgttcccagc tggtgaagtc cgagctggag   2640
gagaagaaat ccgagttgag gcacaagctg aagtacgtgc cccacgagta catcgagctg   2700
atcgagatcg cccggaacag cacccaggac cgtatcctgg agatgaaggt gatggagttc   2760
ttcatgaagg tgtacggcta caggggcaag cacctgggcg gctccaggaa gcccgacggc   2820
gccatctaca ccgtgggctc ccccatcgac tacggcgtga tcgtggacac caaggcctac   2880
tccggcggct acaacctgcc catcggccag gccgacgaaa tgcagaggta cgtggaggag   2940
aaccagacca ggaacaagca catcaacccc aacgagtggt ggaaggtgta cccctccagc   3000
gtgaccgagt tcaagttcct gttcgtgtcc ggccacttca agggcaacta caaggcccag   3060
ctgaccaggc tgaaccacat caccaactgc aacggcgccg tgctgtccgt ggaggagctc   3120
ctgatcggcg gcgagatgat caaggccggc accctgaccc tggaggaggt gaggaggaag   3180
ttcaacaacg gcgagatcaa cttcgcggcc gactgataa                          3219


<210>  34

<211>  3201
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT3L-HD

<400>  34
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacctga ccccacaaca ggtggtggct    960
atcgcctcaa ataacggggg aaaacaggcc ctggagacag tgcagcggct gctccctgtg   1020
ctttgccagg ctcacggact gaccccccag caggtggtcg caatcgccag taacggaggc   1080
ggaaaacaag ccctggaaac agtccagcgc ctcctgcctg tgctgtgtca ggcccacggc   1140
ttgaccccag agcaggtcgt cgccattgct tcccacgatg gcggaaagca ggctctggag   1200
actgtgcaga gactgctccc cgtgctgtgc caggcacacg ggctgacacc tgagcaagtg   1260
gtcgccatcg caagcaacat tggcggcaag caagcccttg agacagtcca agctctgctg   1320
ccagtgcttt gtcaggctca tgggctcacc cccgagcaag tcgtggccat tgcctctcat   1380
gatggcggga agcaggcctt ggagaccgtc cagagactcc tgcccgtgct ctgccaagca   1440
catgggttga ctccagaaca ggtggtcgca attgccagta atattggcgg gaagcaagcg   1500
ttggaaactg tgcaagctct cctccccgtg ctgtgtcagg cacacggcct cacacctgaa   1560
caagtcgtgg caatcgcctc ccatgacggg gggaagcagg ccctggagac agtccagagg   1620
ttgctgcccg tcctttgcca ggcccacggc ctgaccccag aacaagtggt ggctatcgca   1680
agtaacatcg gcgggaaaca agccctcgag acagtgcagg ctctcttgcc tgtcttgtgt   1740
caagcccacg gactgactcc ccaacaggtc gtggccatcg cctctaacaa cgggggcaag   1800
caagcactcg agactgtcca gcgcctcctg cccgtgcttt gccaagctca cggccttacc   1860
cctgagcaag tggtcgctat tgccagcaac attggcggaa agcaagccct ggaaaccgtg   1920
caggcactgc tgccagtgct gtgccaggct catgggctga caccccagca ggtggtggcc   1980
attgcctcaa ataacggagg gaaacaggcc ttggagactg tgcagaggct cctcccagtg   2040
ctgtgtcagg ctcatggcct gactccccag caagtcgtgg ccatcgcaag caacaatggg   2100
gggaagcaag cactggagac cgtccagaga ctgctgcccg tgctctgtca agctcacgga   2160
ctgacaccac aacaggtggt cgccattgct tccaacggcg gcggcaagca agccctggag   2220
acagtgcaaa gactcctgcc tgtgttgtgc caggctcacg gcctgacccc tgagcaggtc   2280
gtggcaatcg cctccaatat cgggggaaaa caggccctcg agaccgtgca ggccctgctt   2340
cctgtccttt gccaggccca cggcctcaca cccgaacagg tcgtcgctat tgccagccat   2400
gacgggggca agcaggctct cgagacagtc cagaggttgc tcccagtgct gtgccaagcc   2460
cacgggctta ctccacagca ggtggtggct atcgccagca acgggggagg gcggccagct   2520
ctggagagca ttgttgccca gttatctcgc cctgatccga gtggcagcgg aagtggcggg   2580
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2640
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2700
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2760
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2820
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2880
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2940
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   3000
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   3060
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   3120
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   3180
aacttcgcgg ccgactgata a                                             3201


<210>  35

<211>  3198
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT3L-N*

<400>  35
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacctga ccccacaaca ggtggtggct    960
atcgcctcaa ataacggggg aaaacaggcc ctggagacag tgcagcggct gctccctgtg   1020
ctttgccagg ctcacggact gaccccccag caggtggtcg caatcgccag taacggaggc   1080
ggaaaacaag ccctggaaac agtccagcgc ctcctgcctg tgctgtgtca ggcccacggc   1140
ttgaccccag agcaggtcgt cgccattgct tcccacgatg gcggaaagca ggctctggag   1200
actgtgcaga gactgctccc cgtgctgtgc caggcacacg ggctgacacc tgagcaagtg   1260
gtcgccatcg caagcaacat tggcggcaag caagcccttg agacagtcca agctctgctg   1320
ccagtgcttt gtcaggctca tgggctcacc cccgagcaag tcgtggccat tgcctctcat   1380
gatggcggga agcaggcctt ggagaccgtc cagagactcc tgcccgtgct ctgccaagca   1440
catgggttga ctccagaaca ggtggtcgca attgccagta atattggcgg gaagcaagcg   1500
ttggaaactg tgcaagctct cctccccgtg ctgtgtcagg cacacggcct cacacctgaa   1560
caagtcgtgg caatcgcctc ccatgacggg gggaagcagg ccctggagac agtccagagg   1620
ttgctgcccg tcctttgcca ggcccacggc ctgaccccag aacaagtggt ggctatcgca   1680
agtaacatcg gcgggaaaca agccctcgag acagtgcagg ctctcttgcc tgtcttgtgt   1740
caagcccacg gactgactcc ccaacaggtc gtggccatcg cctctaacaa cgggggcaag   1800
caagcactcg agactgtcca gcgcctcctg cccgtgcttt gccaagctca cggccttacc   1860
cctgagcaag tggtcgctat tgccagcaac attggcggaa agcaagccct ggaaaccgtg   1920
caggcactgc tgccagtgct gtgccaggct catgggctga caccccagca ggtggtggcc   1980
attgcctcaa ataacggagg gaaacaggcc ttggagactg tgcagaggct cctcccagtg   2040
ctgtgtcagg ctcatggcct gactccccag caagtcgtgg ccatcgcaag caacaatggg   2100
gggaagcaag cactggagac cgtccagaga ctgctgcccg tgctctgtca agctcacgga   2160
ctgacaccac aacaggtggt cgccattgct tccaacggcg gcggcaagca agccctggag   2220
acagtgcaaa gactcctgcc tgtgttgtgc caggctcacg gcctgacccc tgagcaggtc   2280
gtggcaatcg cctccaatat cgggggaaaa caggccctcg agaccgtgca ggccctgctt   2340
cctgtccttt gccaggccca cggcctcaca cccgaacagg tcgtcgctat tgccagcaat   2400
gggggcaagc aggctctcga gacagtccag aggttgctcc cagtgctgtg ccaagcccac   2460
gggcttactc cacagcaggt ggtggctatc gccagcaacg ggggagggcg gccagctctg   2520
gagagcattg ttgcccagtt atctcgccct gatccgagtg gcagcggaag tggcggggat   2580
cctatcagcc gttcccagct ggtgaagtcc gagctggagg agaagaaatc cgagttgagg   2640
cacaagctga agtacgtgcc ccacgagtac atcgagctga tcgagatcgc ccggaacagc   2700
acccaggacc gtatcctgga gatgaaggtg atggagttct tcatgaaggt gtacggctac   2760
aggggcaagc acctgggcgg ctccaggaag cccgacggcg ccatctacac cgtgggctcc   2820
cccatcgact acggcgtgat cgtggacacc aaggcctact ccggcggcta caacctgccc   2880
atcggccagg ccgacgaaat gcagaggtac gtggaggaga accagaccag gaacaagcac   2940
atcaacccca acgagtggtg gaaggtgtac ccctccagcg tgaccgagtt caagttcctg   3000
ttcgtgtccg gccacttcaa gggcaactac aaggcccagc tgaccaggct gaaccacatc   3060
accaactgca acggcgccgt gctgtccgtg gaggagctcc tgatcggcgg cgagatgatc   3120
aaggccggca ccctgaccct ggaggaggtg aggaggaagt tcaacaacgg cgagatcaac   3180
ttcgcggccg actgataa                                                 3198


<210>  36

<211>  3219
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT3R-HD

<400>  36
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc     60
gagagacagc acatggacag catcgatatc gccgacccca ttcgttcgcg cacaccaagt    120
cctgcccgcg agcttctgcc cggaccccaa cccgatgggg ttcagccgac tgcagatcgt    180
ggggtgtctc cgcctgccgg cggccccctg gatggcttgc cggctcggcg gacgatgtcc    240
cggacccggc tgccatctcc ccctgccccc tcacctgcgt tctcggcggg cagcttcagt    300
gacctgttac gtcagttcga tccgtcactt tttaatacat cgctttttga ttcattgcct    360
cccttcggcg ctcaccatac agaggctgcc acaggcgagt gggatgaggt gcaatcgggt    420
ctgcgggcag ccgacgcccc cccacccacc atgcgcgtgg ctgtcactgc cgcgcggccc    480
ccgcgcgcca agccggcgcc gcgacgacgt gctgcgcaac cctccgacgc ttcgccggcg    540
gcgcaggtgg atctacgcac gctcggctac agccagcagc aacaggagaa gatcaaaccg    600
aaggttcgtt cgacagtggc gcagcaccac gaggcactgg tcggccacgg gtttacacac    660
gcgcacatcg ttgcgttaag ccaacacccg gcagcgttag ggaccgtcgc tgtcaagtat    720
caggacatga tcgcagcgtt gccagaggcg acacacgaag cgatcgttgg cgtcggcaaa    780
cagtggtccg gcgcacgcgc tctggaggcc ttgctcacgg tggcgggaga gttgagaggt    840
ccaccgttac agttggacac aggccaactt ctcaagattg caaaacgtgg cggcgtgacc    900
gcagtggagg cagtgcatgc atggcgcaat gcactgacgg gtgccccgct caacctgacc    960
ccacaacagg tggtggctat cgcctcaaat ggcgggggaa aacaggccct ggagacagtg   1020
cagcggctgc tccctgtgct ttgccaggct cacggactga ccccccagca ggtggtcgca   1080
atcgccagta acaacggcgg aaaacaagcc ctggaaacag tccagcgcct cctgcctgtg   1140
ctgtgtcagg cccacggctt gaccccagag caggtcgtcg ccattgcttc ccacgatggc   1200
ggaaagcagg ctctggagac tgtgcagaga ctgctccccg tgctgtgcca ggcacacggg   1260
ctgacacctc agcaagtggt cgccatcgca agcaacaatg gcggcaagca agcccttgag   1320
acagtccaac ggctgctgcc agtgctttgt caggctcatg ggctcacccc ccaacaagtc   1380
gtggccattg cctctaataa cggcgggaag caggccttgg agaccgtcca gagactcctg   1440
cccgtgctct gccaagcaca tgggttgact ccacaacagg tggtcgcaat tgccagtaac   1500
aatggcggga agcaagcgtt ggaaactgtg caaagactcc tccccgtgct gtgtcaggca   1560
cacggcctca cacctcaaca agtcgtggca atcgcctcca acgggggggg gaagcaggcc   1620
ctggagacag tccagaggtt gctgcccgtc ctttgccagg cccacggcct gaccccagaa   1680
caagtggtgg ctatcgcaag tcatgacggc gggaaacaag ccctcgagac agtgcagcgg   1740
ctcttgcctg tcttgtgtca agcccacgga ctgactcccg agcaggtcgt ggccatcgcc   1800
tctaacattg ggggcaagca agcactcgag actgtccagg ccctcctgcc cgtgctttgc   1860
caagctcacg gccttacccc tgagcaagtg gtcgctattg ccagccatga tggcggaaag   1920
caagccctgg aaaccgtgca gagactgctg ccagtgctgt gccaggctca tgggctgaca   1980
ccccagcagg tggtggccat tgcctcaaat ggcggaggga aacaggcctt ggagactgtg   2040
cagaggctcc tcccagtgct gtgtcaggct catggcctga ctccccagca agtcgtggcc   2100
atcgcaagca ataacggggg gaagcaagca ctggagaccg tccagagact gctgcccgtg   2160
ctctgtcaag ctcacggact gacaccacaa caggtggtcg ccattgcttc caacggcggc   2220
ggcaagcaag ccctggagac agtgcaaaga ctcctgcctg tgttgtgcca ggctcacggc   2280
ctgacccctg agcaggtcgt ggcaatcgcc tcccatgacg ggggaaaaca ggccctcgag   2340
accgtgcaga ggctgcttcc tgtcctttgc caggcccacg gcctcacacc cgaacaggtc   2400
gtcgctattg ccagcaatat cgggggcaag caggctctcg agacagtcca ggccttgctc   2460
ccagtgctgt gccaagccca cgggcttact ccacagcagg tggtggctat cgccagcaac   2520
gggggagggc ggccagctct ggagagcatt gttgcccagt tatctcgccc tgatccgagt   2580
ggcagcggaa gtggcgggga tcctatcagc cgttcccagc tggtgaagtc cgagctggag   2640
gagaagaaat ccgagttgag gcacaagctg aagtacgtgc cccacgagta catcgagctg   2700
atcgagatcg cccggaacag cacccaggac cgtatcctgg agatgaaggt gatggagttc   2760
ttcatgaagg tgtacggcta caggggcaag cacctgggcg gctccaggaa gcccgacggc   2820
gccatctaca ccgtgggctc ccccatcgac tacggcgtga tcgtggacac caaggcctac   2880
tccggcggct acaacctgcc catcggccag gccgacgaaa tgcagaggta cgtggaggag   2940
aaccagacca ggaacaagca catcaacccc aacgagtggt ggaaggtgta cccctccagc   3000
gtgaccgagt tcaagttcct gttcgtgtcc ggccacttca agggcaacta caaggcccag   3060
ctgaccaggc tgaaccacat caccaactgc aacggcgccg tgctgtccgt ggaggagctc   3120
ctgatcggcg gcgagatgat caaggccggc accctgaccc tggaggaggt gaggaggaag   3180
ttcaacaacg gcgagatcaa cttcgcggcc gactgataa                          3219


<210>  37

<211>  3216
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT3R-N*

<400>  37
atgggcgatc ctaaaaagaa acgtaaggtc atcgataagg agaccgccgc tgccaagttc     60
gagagacagc acatggacag catcgatatc gccgacccca ttcgttcgcg cacaccaagt    120
cctgcccgcg agcttctgcc cggaccccaa cccgatgggg ttcagccgac tgcagatcgt    180
ggggtgtctc cgcctgccgg cggccccctg gatggcttgc cggctcggcg gacgatgtcc    240
cggacccggc tgccatctcc ccctgccccc tcacctgcgt tctcggcggg cagcttcagt    300
gacctgttac gtcagttcga tccgtcactt tttaatacat cgctttttga ttcattgcct    360
cccttcggcg ctcaccatac agaggctgcc acaggcgagt gggatgaggt gcaatcgggt    420
ctgcgggcag ccgacgcccc cccacccacc atgcgcgtgg ctgtcactgc cgcgcggccc    480
ccgcgcgcca agccggcgcc gcgacgacgt gctgcgcaac cctccgacgc ttcgccggcg    540
gcgcaggtgg atctacgcac gctcggctac agccagcagc aacaggagaa gatcaaaccg    600
aaggttcgtt cgacagtggc gcagcaccac gaggcactgg tcggccacgg gtttacacac    660
gcgcacatcg ttgcgttaag ccaacacccg gcagcgttag ggaccgtcgc tgtcaagtat    720
caggacatga tcgcagcgtt gccagaggcg acacacgaag cgatcgttgg cgtcggcaaa    780
cagtggtccg gcgcacgcgc tctggaggcc ttgctcacgg tggcgggaga gttgagaggt    840
ccaccgttac agttggacac aggccaactt ctcaagattg caaaacgtgg cggcgtgacc    900
gcagtggagg cagtgcatgc atggcgcaat gcactgacgg gtgccccgct caacctgacc    960
ccacaacagg tggtggctat cgcctcaaat ggcgggggaa aacaggccct ggagacagtg   1020
cagcggctgc tccctgtgct ttgccaggct cacggactga ccccccagca ggtggtcgca   1080
atcgccagta acaacggcgg aaaacaagcc ctggaaacag tccagcgcct cctgcctgtg   1140
ctgtgtcagg cccacggctt gaccccagag caggtcgtcg ccattgcttc caatggcgga   1200
aagcaggctc tggagactgt gcagagactg ctccccgtgc tgtgccaggc acacgggctg   1260
acacctcagc aagtggtcgc catcgcaagc aacaatggcg gcaagcaagc ccttgagaca   1320
gtccaacggc tgctgccagt gctttgtcag gctcatgggc tcacccccca acaagtcgtg   1380
gccattgcct ctaataacgg cgggaagcag gccttggaga ccgtccagag actcctgccc   1440
gtgctctgcc aagcacatgg gttgactcca caacaggtgg tcgcaattgc cagtaacaat   1500
ggcgggaagc aagcgttgga aactgtgcaa agactcctcc ccgtgctgtg tcaggcacac   1560
ggcctcacac ctcaacaagt cgtggcaatc gcctccaacg ggggggggaa gcaggccctg   1620
gagacagtcc agaggttgct gcccgtcctt tgccaggccc acggcctgac cccagaacaa   1680
gtggtggcta tcgcaagtca tgacggcggg aaacaagccc tcgagacagt gcagcggctc   1740
ttgcctgtct tgtgtcaagc ccacggactg actcccgagc aggtcgtggc catcgcctct   1800
aacattgggg gcaagcaagc actcgagact gtccaggccc tcctgcccgt gctttgccaa   1860
gctcacggcc ttacccctga gcaagtggtc gctattgcca gccatgatgg cggaaagcaa   1920
gccctggaaa ccgtgcagag actgctgcca gtgctgtgcc aggctcatgg gctgacaccc   1980
cagcaggtgg tggccattgc ctcaaatggc ggagggaaac aggccttgga gactgtgcag   2040
aggctcctcc cagtgctgtg tcaggctcat ggcctgactc cccagcaagt cgtggccatc   2100
gcaagcaata acggggggaa gcaagcactg gagaccgtcc agagactgct gcccgtgctc   2160
tgtcaagctc acggactgac accacaacag gtggtcgcca ttgcttccaa cggcggcggc   2220
aagcaagccc tggagacagt gcaaagactc ctgcctgtgt tgtgccaggc tcacggcctg   2280
acccctgagc aggtcgtggc aatcgcctcc catgacgggg gaaaacaggc cctcgagacc   2340
gtgcagaggc tgcttcctgt cctttgccag gcccacggcc tcacacccga acaggtcgtc   2400
gctattgcca gcaatatcgg gggcaagcag gctctcgaga cagtccaggc cttgctccca   2460
gtgctgtgcc aagcccacgg gcttactcca cagcaggtgg tggctatcgc cagcaacggg   2520
ggagggcggc cagctctgga gagcattgtt gcccagttat ctcgccctga tccgagtggc   2580
agcggaagtg gcggggatcc tatcagccgt tcccagctgg tgaagtccga gctggaggag   2640
aagaaatccg agttgaggca caagctgaag tacgtgcccc acgagtacat cgagctgatc   2700
gagatcgccc ggaacagcac ccaggaccgt atcctggaga tgaaggtgat ggagttcttc   2760
atgaaggtgt acggctacag gggcaagcac ctgggcggct ccaggaagcc cgacggcgcc   2820
atctacaccg tgggctcccc catcgactac ggcgtgatcg tggacaccaa ggcctactcc   2880
ggcggctaca acctgcccat cggccaggcc gacgaaatgc agaggtacgt ggaggagaac   2940
cagaccagga acaagcacat caaccccaac gagtggtgga aggtgtaccc ctccagcgtg   3000
accgagttca agttcctgtt cgtgtccggc cacttcaagg gcaactacaa ggcccagctg   3060
accaggctga accacatcac caactgcaac ggcgccgtgc tgtccgtgga ggagctcctg   3120
atcggcggcg agatgatcaa ggccggcacc ctgaccctgg aggaggtgag gaggaagttc   3180
aacaacggcg agatcaactt cgcggccgac tgataa                             3216


<210>  38

<211>  1065
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-HD

<400>  38
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                405                 410                 415     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        435                 440                 445             


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
465                 470                 475                 480 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
        515                 520                 525             


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
        675                 680                 685             


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
705                 710                 715                 720 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
            740                 745                 750         


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
785                 790                 795                 800 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
                805                 810                 815     


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            820                 825                 830         


Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu 
        835                 840                 845             


Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser 
    850                 855                 860                 


Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
865                 870                 875                 880 


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
                885                 890                 895     


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
            900                 905                 910         


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
        915                 920                 925             


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
    930                 935                 940                 


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
945                 950                 955                 960 


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
                965                 970                 975     


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
            980                 985                 990         


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
        995                 1000                1005            


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
    1010                1015                1020                


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
1025                1030                1035                1040


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
                1045                1050                1055    


Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                1065


<210>  39

<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-N*

<400>  39
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        355                 360                 365             


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
    370                 375                 380                 


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
385                 390                 395                 400 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
                405                 410                 415     


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            420                 425                 430         


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
        435                 440                 445             


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
    450                 455                 460                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
465                 470                 475                 480 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                485                 490                 495     


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
            500                 505                 510         


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
        515                 520                 525             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    530                 535                 540                 


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
545                 550                 555                 560 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                565                 570                 575     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            580                 585                 590         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        595                 600                 605             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    610                 615                 620                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
625                 630                 635                 640 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                645                 650                 655     


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
            660                 665                 670         


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        675                 680                 685             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    690                 695                 700                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
705                 710                 715                 720 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
                725                 730                 735     


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
            740                 745                 750         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        755                 760                 765             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    770                 775                 780                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
785                 790                 795                 800 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                805                 810                 815     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            820                 825                 830         


Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser 
        835                 840                 845             


Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser Arg 
    850                 855                 860                 


Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
865                 870                 875                 880 


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
                885                 890                 895     


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
            900                 905                 910         


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
        915                 920                 925             


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
    930                 935                 940                 


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
945                 950                 955                 960 


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
                965                 970                 975     


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
            980                 985                 990         


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
        995                 1000                1005            


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
    1010                1015                1020                


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
1025                1030                1035                1040


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
                1045                1050                1055    


Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                


<210>  40

<211>  1065
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-NG

<400>  40
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                405                 410                 415     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        435                 440                 445             


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
465                 470                 475                 480 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
        515                 520                 525             


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
        675                 680                 685             


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
705                 710                 715                 720 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
            740                 745                 750         


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
785                 790                 795                 800 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
                805                 810                 815     


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            820                 825                 830         


Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu 
        835                 840                 845             


Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser 
    850                 855                 860                 


Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
865                 870                 875                 880 


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
                885                 890                 895     


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
            900                 905                 910         


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
        915                 920                 925             


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
    930                 935                 940                 


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
945                 950                 955                 960 


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
                965                 970                 975     


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
            980                 985                 990         


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
        995                 1000                1005            


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
    1010                1015                1020                


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
1025                1030                1035                1040


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
                1045                1050                1055    


Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                1065


<210>  41

<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-H*

<400>  41
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser His Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        355                 360                 365             


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
    370                 375                 380                 


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
385                 390                 395                 400 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
                405                 410                 415     


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            420                 425                 430         


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
        435                 440                 445             


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
    450                 455                 460                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
465                 470                 475                 480 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                485                 490                 495     


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
            500                 505                 510         


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
        515                 520                 525             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    530                 535                 540                 


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
545                 550                 555                 560 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                565                 570                 575     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            580                 585                 590         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        595                 600                 605             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    610                 615                 620                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
625                 630                 635                 640 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                645                 650                 655     


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
            660                 665                 670         


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        675                 680                 685             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    690                 695                 700                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
705                 710                 715                 720 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
                725                 730                 735     


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
            740                 745                 750         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        755                 760                 765             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    770                 775                 780                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
785                 790                 795                 800 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                805                 810                 815     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            820                 825                 830         


Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser 
        835                 840                 845             


Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser Arg 
    850                 855                 860                 


Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
865                 870                 875                 880 


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
                885                 890                 895     


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
            900                 905                 910         


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
        915                 920                 925             


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
    930                 935                 940                 


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
945                 950                 955                 960 


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
                965                 970                 975     


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
            980                 985                 990         


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
        995                 1000                1005            


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
    1010                1015                1020                


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
1025                1030                1035                1040


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
                1045                1050                1055    


Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                


<210>  42

<211>  1071
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT1R

<400>  42
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Lys Glu Thr Ala 
1               5                   10                  15      


Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ile Asp Ile Ala Asp 
            20                  25                  30          


Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly 
        35                  40                  45              


Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val Ser Pro 
    50                  55                  60                  


Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr Met Ser 
65                  70                  75                  80  


Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala 
                85                  90                  95      


Gly Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn 
            100                 105                 110         


Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His Thr Glu 
        115                 120                 125             


Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg Ala Ala 
    130                 135                 140                 


Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala Arg Pro 
145                 150                 155                 160 


Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp 
                165                 170                 175     


Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln 
            180                 185                 190         


Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln 
        195                 200                 205             


His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val 
    210                 215                 220                 


Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr 
225                 230                 235                 240 


Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val 
                245                 250                 255     


Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu 
            260                 265                 270         


Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly 
        275                 280                 285             


Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala 
    290                 295                 300                 


Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr 
305                 310                 315                 320 


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            340                 345                 350         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
    370                 375                 380                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            500                 505                 510         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        515                 520                 525             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    530                 535                 540                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
545                 550                 555                 560 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
                565                 570                 575     


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            580                 585                 590         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
        595                 600                 605             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    610                 615                 620                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
625                 630                 635                 640 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                645                 650                 655     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
            660                 665                 670         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        675                 680                 685             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    690                 695                 700                 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
705                 710                 715                 720 


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
                725                 730                 735     


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            740                 745                 750         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        755                 760                 765             


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
    770                 775                 780                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
785                 790                 795                 800 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
                805                 810                 815     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
            820                 825                 830         


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu 
        835                 840                 845             


Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser 
    850                 855                 860                 


Gly Gly Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu 
865                 870                 875                 880 


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
                885                 890                 895     


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
            900                 905                 910         


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
        915                 920                 925             


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
    930                 935                 940                 


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
945                 950                 955                 960 


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
                965                 970                 975     


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
            980                 985                 990         


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
        995                 1000                1005            


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
    1010                1015                1020                


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
1025                1030                1035                1040


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
                1045                1050                1055    


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                1065                1070    


<210>  43

<211>  1065
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT2L-HD

<400>  43
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                405                 410                 415     


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        435                 440                 445             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
465                 470                 475                 480 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
        515                 520                 525             


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
        675                 680                 685             


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
705                 710                 715                 720 


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            740                 745                 750         


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
785                 790                 795                 800 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
                805                 810                 815     


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            820                 825                 830         


Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu 
        835                 840                 845             


Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser 
    850                 855                 860                 


Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
865                 870                 875                 880 


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
                885                 890                 895     


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
            900                 905                 910         


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
        915                 920                 925             


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
    930                 935                 940                 


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
945                 950                 955                 960 


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
                965                 970                 975     


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
            980                 985                 990         


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
        995                 1000                1005            


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
    1010                1015                1020                


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
1025                1030                1035                1040


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
                1045                1050                1055    


Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                1065


<210>  44

<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT2L-N*

<400>  44
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                405                 410                 415     


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        435                 440                 445             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
465                 470                 475                 480 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
                485                 490                 495     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            500                 505                 510         


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
        515                 520                 525             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    530                 535                 540                 


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
545                 550                 555                 560 


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro 
                565                 570                 575     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            580                 585                 590         


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        595                 600                 605             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    610                 615                 620                 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
625                 630                 635                 640 


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                645                 650                 655     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            660                 665                 670         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        675                 680                 685             


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    690                 695                 700                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
705                 710                 715                 720 


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
                725                 730                 735     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            740                 745                 750         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        755                 760                 765             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    770                 775                 780                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
785                 790                 795                 800 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                805                 810                 815     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            820                 825                 830         


Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser 
        835                 840                 845             


Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser Arg 
    850                 855                 860                 


Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
865                 870                 875                 880 


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
                885                 890                 895     


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
            900                 905                 910         


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
        915                 920                 925             


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
    930                 935                 940                 


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
945                 950                 955                 960 


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
                965                 970                 975     


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
            980                 985                 990         


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
        995                 1000                1005            


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
    1010                1015                1020                


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
1025                1030                1035                1040


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
                1045                1050                1055    


Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                


<210>  45

<211>  1071
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT2R

<400>  45
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Lys Glu Thr Ala 
1               5                   10                  15      


Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ile Asp Ile Ala Asp 
            20                  25                  30          


Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly 
        35                  40                  45              


Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val Ser Pro 
    50                  55                  60                  


Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr Met Ser 
65                  70                  75                  80  


Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala 
                85                  90                  95      


Gly Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn 
            100                 105                 110         


Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His Thr Glu 
        115                 120                 125             


Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg Ala Ala 
    130                 135                 140                 


Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala Arg Pro 
145                 150                 155                 160 


Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp 
                165                 170                 175     


Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln 
            180                 185                 190         


Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln 
        195                 200                 205             


His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val 
    210                 215                 220                 


Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr 
225                 230                 235                 240 


Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val 
                245                 250                 255     


Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu 
            260                 265                 270         


Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly 
        275                 280                 285             


Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala 
    290                 295                 300                 


Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr 
305                 310                 315                 320 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            340                 345                 350         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    370                 375                 380                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            500                 505                 510         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        515                 520                 525             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    530                 535                 540                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
545                 550                 555                 560 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
                565                 570                 575     


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            580                 585                 590         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
        595                 600                 605             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    610                 615                 620                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
625                 630                 635                 640 


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
                645                 650                 655     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
            660                 665                 670         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        675                 680                 685             


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
    690                 695                 700                 


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
705                 710                 715                 720 


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
                725                 730                 735     


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            740                 745                 750         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
        755                 760                 765             


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    770                 775                 780                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
785                 790                 795                 800 


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
                805                 810                 815     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
            820                 825                 830         


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu 
        835                 840                 845             


Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser 
    850                 855                 860                 


Gly Gly Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu 
865                 870                 875                 880 


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
                885                 890                 895     


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
            900                 905                 910         


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
        915                 920                 925             


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
    930                 935                 940                 


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
945                 950                 955                 960 


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
                965                 970                 975     


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
            980                 985                 990         


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
        995                 1000                1005            


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
    1010                1015                1020                


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
1025                1030                1035                1040


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
                1045                1050                1055    


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                1065                1070    


<210>  46

<211>  1065
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT3L-HD

<400>  46
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                405                 410                 415     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        435                 440                 445             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
465                 470                 475                 480 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
        515                 520                 525             


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
        675                 680                 685             


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
705                 710                 715                 720 


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            740                 745                 750         


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
785                 790                 795                 800 


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                805                 810                 815     


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            820                 825                 830         


Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu 
        835                 840                 845             


Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser 
    850                 855                 860                 


Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
865                 870                 875                 880 


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
                885                 890                 895     


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
            900                 905                 910         


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
        915                 920                 925             


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
    930                 935                 940                 


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
945                 950                 955                 960 


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
                965                 970                 975     


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
            980                 985                 990         


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
        995                 1000                1005            


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
    1010                1015                1020                


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
1025                1030                1035                1040


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
                1045                1050                1055    


Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                1065


<210>  47

<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT3L-N*

<400>  47
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                405                 410                 415     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        435                 440                 445             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
465                 470                 475                 480 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
        515                 520                 525             


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
        675                 680                 685             


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
705                 710                 715                 720 


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            740                 745                 750         


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
785                 790                 795                 800 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                805                 810                 815     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            820                 825                 830         


Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser 
        835                 840                 845             


Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser Arg 
    850                 855                 860                 


Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
865                 870                 875                 880 


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
                885                 890                 895     


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
            900                 905                 910         


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
        915                 920                 925             


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
    930                 935                 940                 


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
945                 950                 955                 960 


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
                965                 970                 975     


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
            980                 985                 990         


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
        995                 1000                1005            


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
    1010                1015                1020                


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
1025                1030                1035                1040


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
                1045                1050                1055    


Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                


<210>  48

<211>  1071
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT3R-HD

<400>  48
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Lys Glu Thr Ala 
1               5                   10                  15      


Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ile Asp Ile Ala Asp 
            20                  25                  30          


Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly 
        35                  40                  45              


Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val Ser Pro 
    50                  55                  60                  


Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr Met Ser 
65                  70                  75                  80  


Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala 
                85                  90                  95      


Gly Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn 
            100                 105                 110         


Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His Thr Glu 
        115                 120                 125             


Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg Ala Ala 
    130                 135                 140                 


Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala Arg Pro 
145                 150                 155                 160 


Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp 
                165                 170                 175     


Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln 
            180                 185                 190         


Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln 
        195                 200                 205             


His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val 
    210                 215                 220                 


Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr 
225                 230                 235                 240 


Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val 
                245                 250                 255     


Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu 
            260                 265                 270         


Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly 
        275                 280                 285             


Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala 
    290                 295                 300                 


Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr 
305                 310                 315                 320 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            340                 345                 350         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    370                 375                 380                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
385                 390                 395                 400 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                405                 410                 415     


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
            420                 425                 430         


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        435                 440                 445             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            500                 505                 510         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
        515                 520                 525             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    530                 535                 540                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
545                 550                 555                 560 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                565                 570                 575     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            580                 585                 590         


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
        595                 600                 605             


Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    610                 615                 620                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
625                 630                 635                 640 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                645                 650                 655     


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
            660                 665                 670         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        675                 680                 685             


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
    690                 695                 700                 


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
705                 710                 715                 720 


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
                725                 730                 735     


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            740                 745                 750         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        755                 760                 765             


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    770                 775                 780                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
785                 790                 795                 800 


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
                805                 810                 815     


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
            820                 825                 830         


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu 
        835                 840                 845             


Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser 
    850                 855                 860                 


Gly Gly Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu 
865                 870                 875                 880 


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
                885                 890                 895     


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
            900                 905                 910         


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
        915                 920                 925             


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
    930                 935                 940                 


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
945                 950                 955                 960 


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
                965                 970                 975     


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
            980                 985                 990         


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
        995                 1000                1005            


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
    1010                1015                1020                


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
1025                1030                1035                1040


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
                1045                1050                1055    


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                1065                1070    


<210>  49

<211>  1070
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT3R-N*

<400>  49
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Lys Glu Thr Ala 
1               5                   10                  15      


Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ile Asp Ile Ala Asp 
            20                  25                  30          


Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly 
        35                  40                  45              


Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val Ser Pro 
    50                  55                  60                  


Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr Met Ser 
65                  70                  75                  80  


Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala 
                85                  90                  95      


Gly Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn 
            100                 105                 110         


Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His Thr Glu 
        115                 120                 125             


Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg Ala Ala 
    130                 135                 140                 


Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala Arg Pro 
145                 150                 155                 160 


Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp 
                165                 170                 175     


Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln 
            180                 185                 190         


Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln 
        195                 200                 205             


His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val 
    210                 215                 220                 


Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr 
225                 230                 235                 240 


Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val 
                245                 250                 255     


Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu 
            260                 265                 270         


Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly 
        275                 280                 285             


Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala 
    290                 295                 300                 


Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr 
305                 310                 315                 320 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                325                 330                 335     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            340                 345                 350         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
        355                 360                 365             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    370                 375                 380                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
385                 390                 395                 400 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                405                 410                 415     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
            420                 425                 430         


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
        435                 440                 445             


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
    450                 455                 460                 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
465                 470                 475                 480 


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
                485                 490                 495     


Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
            500                 505                 510         


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
        515                 520                 525             


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
    530                 535                 540                 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
545                 550                 555                 560 


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
                565                 570                 575     


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
            580                 585                 590         


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
        595                 600                 605             


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
    610                 615                 620                 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
625                 630                 635                 640 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
                645                 650                 655     


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly 
            660                 665                 670         


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
        675                 680                 685             


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
    690                 695                 700                 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
705                 710                 715                 720 


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
                725                 730                 735     


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
            740                 745                 750         


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
        755                 760                 765             


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
    770                 775                 780                 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
785                 790                 795                 800 


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
                805                 810                 815     


Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
            820                 825                 830         


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser 
        835                 840                 845             


Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly 
    850                 855                 860                 


Gly Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu 
865                 870                 875                 880 


Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr 
                885                 890                 895     


Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu 
            900                 905                 910         


Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly 
        915                 920                 925             


Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val 
    930                 935                 940                 


Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser 
945                 950                 955                 960 


Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr 
                965                 970                 975     


Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp 
            980                 985                 990         


Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val 
        995                 1000                1005            


Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn 
    1010                1015                1020                


His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu 
1025                1030                1035                1040


Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val 
                1045                1050                1055    


Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                1065                1070


<210>  50

<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  xpc2 locus

<400>  50
tgggtccgag atgtcacaca gaggtacgac ccagtctgga tgaca                     45


<210>  51

<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  xpc3 locus

<400>  51
tgtcacacag aggtacgacc cagtctggat gacagtgacc cgcaa                     45


<210>  52

<211>  3198
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-T*

<400>  52
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacttga cccctgagca ggtggtggct    960
attgcctctc acgatggcgg gaaacaggcc ctggaaacag tgcagcggct cctgcccgtg   1020
ctgtgccaag cccacggcct cacaccagaa caggtggtcg ccatcgcctc cacaggcggc   1080
aaacaagccc tggagactgt gcagcgcctg ttgcccgtcc tgtgccaggc tcacgggctg   1140
actcctcagc aagtcgtggc cattgccagc aataacggag ggaagcaggc actggagaca   1200
gtccagaggc tgctgcctgt cctctgtcag gcccacgggc tcactcccga acaagtggtc   1260
gcaatcgcca gcaacatcgg gggaaagcag gctttggaaa ccgtgcaggc cctgctgccc   1320
gtgttgtgtc aggcacacgg cttgacccca cagcaagtgg tggccatcgc cagtaacaac   1380
ggaggcaaac aggctcttga gacagtgcaa agactcctgc cagtcctctg ccaggcacat   1440
gggctgaccc ccgagcaggt cgtggctatc gcctccaaca ttgggggaaa acaggcattg   1500
gagaccgtcc aggcccttct gcctgtgctt tgtcaagcac acggactgac cccccaacaa   1560
gtcgtcgcca ttgcctcaaa cgggggcggg aagcaagccc ttgaaacagt ccagcggctg   1620
ttgccagtgc tctgccaagc tcacgggttg acaccccaac aggtcgtcgc aattgcttcc   1680
aacaacggcg gcaagcaggc cctcgaaacc gtccagagac tcctccccgt cttgtgtcag   1740
gctcatggcc tgacccccca gcaggtggtc gctattgcca gcaatggggg gggcaaacag   1800
gccctggaga cagtgcagag gctcctccca gtgctctgtc aggcacatgg gctgacacca   1860
gagcaagtgg tcgccatcgc cagccatgat ggcgggaaac aggcactgga gaccgtccag   1920
cggttgcttc ctgtcctttg ccaagcacat ggcttgacac ctgagcaggt cgtcgccatt   1980
gcttccaaca ttggcggcaa gcaagccctg gaaaccgtcc aggccctgct ccccgtgctg   2040
tgccaggccc acgggctcac acccgaacag gtcgtggcta tcgccagtca cgatggaggc   2100
aaacaagctc tggaaacagt ccagagactg ctgcccgtcc tctgccaggc tcacgggttg   2160
actcccgagc aagtcgtcgc aatcgcaagc aacatcggag ggaagcaagc actggaaact   2220
gtccaggcac tcctgcctgt cctgtgccaa gcccacggac tgacccccga acaagtcgtg   2280
gccattgcct cacatgacgg gggaaagcag gctcttgaga cagtccagcg cctgctccca   2340
gtcctgtgtc aagcacacgg cttgacccct gaacaagtgg tggcaatcgc ttctaacatt   2400
gggggcaagc aggcccttga gactgtccaa gcactgctgc cagtgctttg ccaggcacac   2460
gggctgactc cacaacaggt ggtggccatc gctagcaacg gaggcgggag gccagccctc   2520
gagagcattg ttgcccagtt atctcgccct gatccgagtg gcagcggaag tggcggggat   2580
cctatcagcc gttcccagct ggtgaagtcc gagctggagg agaagaaatc cgagttgagg   2640
cacaagctga agtacgtgcc ccacgagtac atcgagctga tcgagatcgc ccggaacagc   2700
acccaggacc gtatcctgga gatgaaggtg atggagttct tcatgaaggt gtacggctac   2760
aggggcaagc acctgggcgg ctccaggaag cccgacggcg ccatctacac cgtgggctcc   2820
cccatcgact acggcgtgat cgtggacacc aaggcctact ccggcggcta caacctgccc   2880
atcggccagg ccgacgaaat gcagaggtac gtggaggaga accagaccag gaacaagcac   2940
atcaacccca acgagtggtg gaaggtgtac ccctccagcg tgaccgagtt caagttcctg   3000
ttcgtgtccg gccacttcaa gggcaactac aaggcccagc tgaccaggct gaaccacatc   3060
accaactgca acggcgccgt gctgtccgtg gaggagctcc tgatcggcgg cgagatgatc   3120
aaggccggca ccctgaccct ggaggaggtg aggaggaagt tcaacaacgg cgagatcaac   3180
ttcgcggccg actgataa                                                 3198


<210>  53

<211>  3198
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-Q*

<400>  53
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacttga cccctgagca ggtggtggct    960
attgcctctc acgatggcgg gaaacaggcc ctggaaacag tgcagcggct cctgcccgtg   1020
ctgtgccaag cccacggcct cacaccagaa caggtggtcg ccatcgcctc ccaaggcggc   1080
aaacaagccc tggagactgt gcagcgcctg ttgcccgtcc tgtgccaggc tcacgggctg   1140
actcctcagc aagtcgtggc cattgccagc aataacggag ggaagcaggc actggagaca   1200
gtccagaggc tgctgcctgt cctctgtcag gcccacgggc tcactcccga acaagtggtc   1260
gcaatcgcca gcaacatcgg gggaaagcag gctttggaaa ccgtgcaggc cctgctgccc   1320
gtgttgtgtc aggcacacgg cttgacccca cagcaagtgg tggccatcgc cagtaacaac   1380
ggaggcaaac aggctcttga gacagtgcaa agactcctgc cagtcctctg ccaggcacat   1440
gggctgaccc ccgagcaggt cgtggctatc gcctccaaca ttgggggaaa acaggcattg   1500
gagaccgtcc aggcccttct gcctgtgctt tgtcaagcac acggactgac cccccaacaa   1560
gtcgtcgcca ttgcctcaaa cgggggcggg aagcaagccc ttgaaacagt ccagcggctg   1620
ttgccagtgc tctgccaagc tcacgggttg acaccccaac aggtcgtcgc aattgcttcc   1680
aacaacggcg gcaagcaggc cctcgaaacc gtccagagac tcctccccgt cttgtgtcag   1740
gctcatggcc tgacccccca gcaggtggtc gctattgcca gcaatggggg gggcaaacag   1800
gccctggaga cagtgcagag gctcctccca gtgctctgtc aggcacatgg gctgacacca   1860
gagcaagtgg tcgccatcgc cagccatgat ggcgggaaac aggcactgga gaccgtccag   1920
cggttgcttc ctgtcctttg ccaagcacat ggcttgacac ctgagcaggt cgtcgccatt   1980
gcttccaaca ttggcggcaa gcaagccctg gaaaccgtcc aggccctgct ccccgtgctg   2040
tgccaggccc acgggctcac acccgaacag gtcgtggcta tcgccagtca cgatggaggc   2100
aaacaagctc tggaaacagt ccagagactg ctgcccgtcc tctgccaggc tcacgggttg   2160
actcccgagc aagtcgtcgc aatcgcaagc aacatcggag ggaagcaagc actggaaact   2220
gtccaggcac tcctgcctgt cctgtgccaa gcccacggac tgacccccga acaagtcgtg   2280
gccattgcct cacatgacgg gggaaagcag gctcttgaga cagtccagcg cctgctccca   2340
gtcctgtgtc aagcacacgg cttgacccct gaacaagtgg tggcaatcgc ttctaacatt   2400
gggggcaagc aggcccttga gactgtccaa gcactgctgc cagtgctttg ccaggcacac   2460
gggctgactc cacaacaggt ggtggccatc gctagcaacg gaggcgggag gccagccctc   2520
gagagcattg ttgcccagtt atctcgccct gatccgagtg gcagcggaag tggcggggat   2580
cctatcagcc gttcccagct ggtgaagtcc gagctggagg agaagaaatc cgagttgagg   2640
cacaagctga agtacgtgcc ccacgagtac atcgagctga tcgagatcgc ccggaacagc   2700
acccaggacc gtatcctgga gatgaaggtg atggagttct tcatgaaggt gtacggctac   2760
aggggcaagc acctgggcgg ctccaggaag cccgacggcg ccatctacac cgtgggctcc   2820
cccatcgact acggcgtgat cgtggacacc aaggcctact ccggcggcta caacctgccc   2880
atcggccagg ccgacgaaat gcagaggtac gtggaggaga accagaccag gaacaagcac   2940
atcaacccca acgagtggtg gaaggtgtac ccctccagcg tgaccgagtt caagttcctg   3000
ttcgtgtccg gccacttcaa gggcaactac aaggcccagc tgaccaggct gaaccacatc   3060
accaactgca acggcgccgt gctgtccgtg gaggagctcc tgatcggcgg cgagatgatc   3120
aaggccggca ccctgaccct ggaggaggtg aggaggaagt tcaacaacgg cgagatcaac   3180
ttcgcggccg actgataa                                                 3198


<210>  54

<211>  3201
<212>  DNA
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-HG

<400>  54
atgggcgatc ctaaaaagaa acgtaaggtc atcgattacc catacgatgt tccagattac     60
gctatcgata tcgccgaccc cattcgttcg cgcacaccaa gtcctgcccg cgagcttctg    120
cccggacccc aacccgatgg ggttcagccg actgcagatc gtggggtgtc tccgcctgcc    180
ggcggccccc tggatggctt gccggctcgg cggacgatgt cccggacccg gctgccatct    240
ccccctgccc cctcacctgc gttctcggcg ggcagcttca gtgacctgtt acgtcagttc    300
gatccgtcac tttttaatac atcgcttttt gattcattgc ctcccttcgg cgctcaccat    360
acagaggctg ccacaggcga gtgggatgag gtgcaatcgg gtctgcgggc agccgacgcc    420
cccccaccca ccatgcgcgt ggctgtcact gccgcgcggc ccccgcgcgc caagccggcg    480
ccgcgacgac gtgctgcgca accctccgac gcttcgccgg cggcgcaggt ggatctacgc    540
acgctcggct acagccagca gcaacaggag aagatcaaac cgaaggttcg ttcgacagtg    600
gcgcagcacc acgaggcact ggtcggccac gggtttacac acgcgcacat cgttgcgtta    660
agccaacacc cggcagcgtt agggaccgtc gctgtcaagt atcaggacat gatcgcagcg    720
ttgccagagg cgacacacga agcgatcgtt ggcgtcggca aacagtggtc cggcgcacgc    780
gctctggagg ccttgctcac ggtggcggga gagttgagag gtccaccgtt acagttggac    840
acaggccaac ttctcaagat tgcaaaacgt ggcggcgtga ccgcagtgga ggcagtgcat    900
gcatggcgca atgcactgac gggtgccccg ctcaacctga ccccagaaca ggtggtggct    960
atcgcctcac acgatggggg aaaacaggcc ctggagacag tgcagcggct gctccctgtg   1020
ctttgccagg ctcacggact gacccccgag caggtggtcg caatcgccag tcacgggggc   1080
ggaaaacaag ccctggaaac agtccagcgc ctcctgcctg tgctgtgtca ggcccacggc   1140
ttgaccccac agcaggtcgt cgccattgct tccaacaatg gcggaaagca ggctctggag   1200
actgtgcaga gactgctccc cgtgctgtgc caggcacacg ggctgacacc tgagcaagtg   1260
gtcgccatcg caagcaacat tggcggcaag caagcccttg agacagtcca agctctgctg   1320
ccagtgcttt gtcaggctca tgggctcacc ccccagcaag tcgtggccat tgcctctaac   1380
aacggcggga agcaggcctt ggagaccgtc cagagactcc tgcccgtgct ctgccaagca   1440
catgggttga ctccagaaca ggtggtcgca attgccagta acatcggcgg gaagcaagcg   1500
ttggaaactg tgcaagctct cctccccgtg ctgtgtcagg cacacggcct cacacctcaa   1560
caagtcgtgg caatcgcctc caacgggggg gggaagcagg ccctggagac agtccagagg   1620
ttgctgcccg tcctttgcca ggcccacggc ctgaccccac aacaagtggt ggctatcgca   1680
agtaacaatg gcgggaaaca agccctcgag acagtgcagc ggctcttgcc tgtcttgtgt   1740
caagcccacg gactgactcc ccaacaggtc gtggccatcg cctctaacgg cgggggcaag   1800
caagcactcg agactgtcca gcgcctcctg cccgtgcttt gccaagctca cggccttacc   1860
cctgagcaag tggtcgctat tgccagccat gatggcggaa agcaagccct ggaaaccgtg   1920
cagaggctgc tgccagtgct gtgccaggct catgggctga cacccgagca ggtggtggcc   1980
attgcctcaa atattggagg gaaacaggcc ttggagactg tgcaggcact cctcccagtg   2040
ctgtgtcagg ctcatggcct gactcccgag caagtcgtgg ccatcgcaag ccacgacggg   2100
gggaagcaag cactggagac cgtccagaga ctgctgcccg tgctctgtca agctcacgga   2160
ctgacaccag aacaggtggt cgccattgct tccaacattg gcggcaagca agccctggag   2220
acagtgcaag ctctcctgcc tgtgttgtgc caggctcacg gcctgacccc tgagcaggtc   2280
gtggcaatcg cctcccatga cgggggaaaa caggccctcg agaccgtgca gaggctgctt   2340
cctgtccttt gccaggccca cggcctcaca cccgaacagg tcgtcgctat tgccagcaat   2400
atcgggggca agcaggctct cgagacagtc caggccttgc tcccagtgct gtgccaagcc   2460
cacgggctta ctccacagca ggtggtggct atcgccagca acgggggagg gcggccagct   2520
ctggagagca ttgttgccca gttatctcgc cctgatccga gtggcagcgg aagtggcggg   2580
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2640
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2700
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2760
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2820
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2880
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2940
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   3000
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   3060
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   3120
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   3180
aacttcgcgg ccgactgata a                                             3201


<210>  55

<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-T*

<400>  55
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Thr Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        355                 360                 365             


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
    370                 375                 380                 


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
385                 390                 395                 400 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
                405                 410                 415     


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            420                 425                 430         


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
        435                 440                 445             


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
    450                 455                 460                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
465                 470                 475                 480 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                485                 490                 495     


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
            500                 505                 510         


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
        515                 520                 525             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    530                 535                 540                 


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
545                 550                 555                 560 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                565                 570                 575     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            580                 585                 590         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        595                 600                 605             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    610                 615                 620                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
625                 630                 635                 640 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                645                 650                 655     


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
            660                 665                 670         


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        675                 680                 685             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    690                 695                 700                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
705                 710                 715                 720 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
                725                 730                 735     


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
            740                 745                 750         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        755                 760                 765             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    770                 775                 780                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
785                 790                 795                 800 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                805                 810                 815     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            820                 825                 830         


Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser 
        835                 840                 845             


Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser Arg 
    850                 855                 860                 


Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
865                 870                 875                 880 


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
                885                 890                 895     


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
            900                 905                 910         


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
        915                 920                 925             


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
    930                 935                 940                 


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
945                 950                 955                 960 


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
                965                 970                 975     


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
            980                 985                 990         


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
        995                 1000                1005            


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
    1010                1015                1020                


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
1025                1030                1035                1040


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
                1045                1050                1055    


Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                


<210>  56

<211>  1064
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-Q*

<400>  56
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser Gln Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        355                 360                 365             


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
    370                 375                 380                 


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
385                 390                 395                 400 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
                405                 410                 415     


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
            420                 425                 430         


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
        435                 440                 445             


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
    450                 455                 460                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
465                 470                 475                 480 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                485                 490                 495     


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
            500                 505                 510         


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
        515                 520                 525             


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
    530                 535                 540                 


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
545                 550                 555                 560 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                565                 570                 575     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            580                 585                 590         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        595                 600                 605             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
    610                 615                 620                 


Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
625                 630                 635                 640 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                645                 650                 655     


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
            660                 665                 670         


Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        675                 680                 685             


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
    690                 695                 700                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
705                 710                 715                 720 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
                725                 730                 735     


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
            740                 745                 750         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
        755                 760                 765             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    770                 775                 780                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile 
785                 790                 795                 800 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu 
                805                 810                 815     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            820                 825                 830         


Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser 
        835                 840                 845             


Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser Arg 
    850                 855                 860                 


Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
865                 870                 875                 880 


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
                885                 890                 895     


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
            900                 905                 910         


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
        915                 920                 925             


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
    930                 935                 940                 


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
945                 950                 955                 960 


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
                965                 970                 975     


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
            980                 985                 990         


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
        995                 1000                1005            


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
    1010                1015                1020                


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
1025                1030                1035                1040


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
                1045                1050                1055    


Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                


<210>  57

<211>  1065
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN XPCT1L-HG

<400>  57
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Pro Ile Arg Ser Arg Thr 
            20                  25                  30          


Pro Ser Pro Ala Arg Glu Leu Leu Pro Gly Pro Gln Pro Asp Gly Val 
        35                  40                  45              


Gln Pro Thr Ala Asp Arg Gly Val Ser Pro Pro Ala Gly Gly Pro Leu 
    50                  55                  60                  


Asp Gly Leu Pro Ala Arg Arg Thr Met Ser Arg Thr Arg Leu Pro Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Ser Pro Ala Phe Ser Ala Gly Ser Phe Ser Asp Leu 
                85                  90                  95      


Leu Arg Gln Phe Asp Pro Ser Leu Phe Asn Thr Ser Leu Phe Asp Ser 
            100                 105                 110         


Leu Pro Pro Phe Gly Ala His His Thr Glu Ala Ala Thr Gly Glu Trp 
        115                 120                 125             


Asp Glu Val Gln Ser Gly Leu Arg Ala Ala Asp Ala Pro Pro Pro Thr 
    130                 135                 140                 


Met Arg Val Ala Val Thr Ala Ala Arg Pro Pro Arg Ala Lys Pro Ala 
145                 150                 155                 160 


Pro Arg Arg Arg Ala Ala Gln Pro Ser Asp Ala Ser Pro Ala Ala Gln 
                165                 170                 175     


Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
            180                 185                 190         


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
        195                 200                 205             


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
    210                 215                 220                 


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
225                 230                 235                 240 


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
                245                 250                 255     


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
            260                 265                 270         


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
        275                 280                 285             


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
    290                 295                 300                 


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala 
305                 310                 315                 320 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                325                 330                 335     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            340                 345                 350         


Val Ala Ile Ala Ser His Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
        355                 360                 365             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
    370                 375                 380                 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
385                 390                 395                 400 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                405                 410                 415     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
            420                 425                 430         


Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        435                 440                 445             


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
    450                 455                 460                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
465                 470                 475                 480 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
                485                 490                 495     


Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys 
            500                 505                 510         


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
        515                 520                 525             


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    530                 535                 540                 


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
545                 550                 555                 560 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                565                 570                 575     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
            580                 585                 590         


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        595                 600                 605             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
    610                 615                 620                 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
625                 630                 635                 640 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
                645                 650                 655     


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
            660                 665                 670         


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
        675                 680                 685             


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
    690                 695                 700                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
705                 710                 715                 720 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
                725                 730                 735     


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
            740                 745                 750         


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
        755                 760                 765             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    770                 775                 780                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
785                 790                 795                 800 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
                805                 810                 815     


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
            820                 825                 830         


Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu 
        835                 840                 845             


Ser Arg Pro Asp Pro Ser Gly Ser Gly Ser Gly Gly Asp Pro Ile Ser 
    850                 855                 860                 


Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
865                 870                 875                 880 


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
                885                 890                 895     


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
            900                 905                 910         


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
        915                 920                 925             


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
    930                 935                 940                 


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
945                 950                 955                 960 


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
                965                 970                 975     


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
            980                 985                 990         


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
        995                 1000                1005            


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
    1010                1015                1020                


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
1025                1030                1035                1040


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
                1045                1050                1055    


Asn Gly Glu Ile Asn Phe Ala Ala Asp 
            1060                1065













