                         SEQUENCE LISTING

<110>  Boehringer Ingelheim International GmbH
 
<120>  ANG2-BINDING MOLECULES

<130>  12-0350-PCT

<160>  190   

<170>  PatentIn version 3.3

<210>  1
<211>  124
<212>  PRT
<213>  Lama glama

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Ala Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Cys Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  111
<212>  PRT
<213>  Lama glama

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val His Ser Gly Thr Ile Ser Ser Thr His 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu His Val 
        35                  40                  45              


Ala Thr Phe Thr Asn Arg Gly Ser Thr Tyr Tyr Ala Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Thr Gly Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     


<210>  3
<211>  120
<212>  PRT
<213>  Lama glama

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Ser 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Ser Gly Ser Ser Thr Asp Ser Ala Gln Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly 
                85                  90                  95      


Arg Ala Phe Leu Ala Arg Asp Thr Phe Tyr Tyr Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  126
<212>  PRT
<213>  Lama glama

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asp Asp His 
            20                  25                  30          


Leu Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Ser Arg Ser Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Pro Ala Trp Gly Arg Pro Ala Ser Pro Leu Pro Tyr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  5
<211>  134
<212>  PRT
<213>  Lama glama

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser Ser Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Leu Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Glu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Asp Trp Asp Phe Glu Asp Ile Pro Glu Tyr Tyr Cys Ser 
            100                 105                 110         


Gly Tyr Gly Cys Asp Glu Ser Leu Phe Asp Ser Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  6
<211>  130
<212>  PRT
<213>  Lama glama

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Asp 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Thr Ser Ser Asp Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Asn Arg Arg Ile Tyr Tyr Ser Asp Tyr Ala Leu Ala Cys 
            100                 105                 110         


Phe Pro Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  7
<211>  123
<212>  PRT
<213>  Lama glama

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Val Ile Trp Ser Ser Gly Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  8
<211>  130
<212>  PRT
<213>  Lama glama

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Asn Leu Arg Ile Tyr Tyr Ser Asp Tyr Ala Leu Ala Cys 
            100                 105                 110         


Phe Pro Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  9
<211>  123
<212>  PRT
<213>  Lama glama

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Gly Ile Trp Ser Ser Gly Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  123
<212>  PRT
<213>  Lama glama

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Ala Met Trp Ser Ser Gly Val Pro Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Gly Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Glu Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  11
<211>  124
<212>  PRT
<213>  Lama glama

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Thr His Ile Thr Trp Asn Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Ile Lys Tyr Gly Ala Val Thr His Pro Glu Glu Tyr Ser 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  12
<211>  126
<212>  PRT
<213>  Lama glama

<400>  12

Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asp Asp His 
            20                  25                  30          


Leu Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Ser Arg Ser Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Pro Ala Trp Gly Arg Pro Ala Ser Pro Leu Pro Tyr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  13
<211>  134
<212>  PRT
<213>  Lama glama

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Val Pro Ala Thr Arg Arg Thr Pro Gln Met Val Ala Ala Asn 
            100                 105                 110         


Val Cys Trp Leu Ala Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  14
<211>  123
<212>  PRT
<213>  Lama glama

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Gly Ile Trp Ser Ser Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  15
<211>  123
<212>  PRT
<213>  Lama glama

<400>  15

Glu Val Gln Leu Val Glu Phe Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Gly Ile Trp Ser Ser Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Glu Arg Phe Thr Val Ser Arg Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  16
<211>  123
<212>  PRT
<213>  Lama glama

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Val Ile Trp Ser Ser Gly Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Gly Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Glu Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  17
<211>  126
<212>  PRT
<213>  Lama glama

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ile Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Met Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  18
<211>  124
<212>  PRT
<213>  Lama glama

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu Phe Val 
        35                  40                  45              


Thr Ala Val Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Ser Thr Ile Val Glu Val Thr Thr Leu Glu Ala Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  19
<211>  122
<212>  PRT
<213>  Lama glama

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Pro Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala His Ile Thr Trp Ser Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Arg Arg Tyr Gly Ile Val Asp Arg Asp Tyr Asn Asp Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  116
<212>  PRT
<213>  Lama glama

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ile Ala Ser Gly Arg Asp Ile Phe Ser Val 
            20                  25                  30          


Ser Ala Thr Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe 
        35                  40                  45              


Val Ala Gly Ile Ser Asn Ile Gly Ala Thr Lys Phe Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Leu Leu Trp Ser Gly Asn Leu Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  21
<211>  116
<212>  PRT
<213>  Lama glama

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Arg Asp Ile Phe Ser Ile 
            20                  25                  30          


Thr Ala Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe 
        35                  40                  45              


Val Ala Gly Ile Ser Asn Ile Gly Ala Thr Lys Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Leu Leu Trp Ser Ala Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  22
<211>  126
<212>  PRT
<213>  Lama glama

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Asp Asp His 
            20                  25                  30          


Leu Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Ser Arg Ser Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Pro Ala Trp Gly Arg Pro Ala Ser Pro Leu Pro Tyr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  23
<211>  134
<212>  PRT
<213>  Lama glama

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Val Pro Ala Thr Arg Arg Thr Pro Gln Met Val Val Ala Asn 
            100                 105                 110         


Val Cys Trp Leu Ala Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  24
<211>  125
<212>  PRT
<213>  Lama glama

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ile Thr Pro Cys Ser Asp Tyr Thr Gln Thr Tyr Glu Tyr 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  25
<211>  134
<212>  PRT
<213>  Lama glama

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Arg Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Val Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Val Pro Ala Thr Arg Arg Thr Pro Gln Met Val Val Ala Asn 
            100                 105                 110         


Met Cys Trp Leu Ala Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  26
<211>  125
<212>  PRT
<213>  Lama glama

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ile Thr Pro Cys Ser Asp Tyr Thr Gln Thr Tyr Glu Tyr 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  27
<211>  134
<212>  PRT
<213>  Lama glama

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Val Pro Ala Thr Arg Arg Thr Pro Gln Met Val Val Ala Asn 
            100                 105                 110         


Val Cys Trp Leu Ala Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  28
<211>  132
<212>  PRT
<213>  Lama glama

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ser Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Pro Thr Leu Arg Val Arg Leu Asp Asn Asp Arg His His 
            100                 105                 110         


Leu Leu Tyr Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  29
<211>  134
<212>  PRT
<213>  Lama glama

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Val Pro Ala Thr Arg Arg Thr Pro Gln Met Val Val Leu Asn 
            100                 105                 110         


Met Cys Trp Leu Ala Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  30
<211>  125
<212>  PRT
<213>  Lama glama

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ile Thr Pro Cys Ser Asp Tyr Thr Gln Thr Tyr Glu Tyr 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  31
<211>  134
<212>  PRT
<213>  Lama glama

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Thr Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Val Pro Ala Thr Arg Arg Thr Pro Gln Met Val Asp Ala Asn 
            100                 105                 110         


Met Cys Trp Leu Ala Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  32
<211>  127
<212>  PRT
<213>  Lama glama

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Arg Phe Gly Gly His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Tyr Trp Thr Ser Gly Met Thr Arg Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ile Lys Asp Phe Gln Leu Arg Val Asp Val Thr Ser Ala Ser 
            100                 105                 110         


Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  33
<211>  127
<212>  PRT
<213>  Lama glama

<400>  33

Gly Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Arg Phe Gly Gly His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Tyr Trp Thr Thr Gly Met Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Ile Arg Asp Phe Asn Ile Arg Leu Asp Val Thr Ser Ala Ser 
            100                 105                 110         


Ala Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  34
<211>  123
<212>  PRT
<213>  Lama glama

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Gly Ile Trp Ser Ser Gly Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  35
<211>  123
<212>  PRT
<213>  Lama glama

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Val Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Ala Ile Trp Ser Ser Gly Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Gly Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Glu Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  36
<211>  121
<212>  PRT
<213>  Lama glama

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Asn 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Val Pro Gly Lys Val Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Arg Trp Asn Val Gly Arg Leu Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Ala Gly Leu Val Phe Ser Gly Ile Pro Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  37
<211>  118
<212>  PRT
<213>  Lama glama

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Arg Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Leu Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Ser Asp Tyr Ser Ser Asp Tyr Tyr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  38
<211>  133
<212>  PRT
<213>  Lama glama

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Gly Gly Asp Thr Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Ala Gly Val Pro Ala Gly Pro Ala Ala Val Tyr Gly 
            100                 105                 110         


Ser Thr Cys Ser Arg Leu Glu Tyr Asp Tyr Trp Gly Gln Gly Ala Gln 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  39
<211>  124
<212>  PRT
<213>  Lama glama

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ile 
        35                  40                  45              


Ala Ala Ile Asn Trp Asn Gly Asp Ser Thr Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Gly Trp Gly Arg Ala Tyr Glu Gln Ala Tyr Glu Tyr Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  40
<211>  119
<212>  PRT
<213>  Lama glama

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Trp Asn Asp Glu Tyr Thr Tyr Tyr Ala Glu Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Ser Arg Leu Tyr Asp Tyr His Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  41
<211>  123
<212>  PRT
<213>  Lama glama

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Pro Pro Phe His Ser Cys Ser Glu Tyr Glu Asn Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  42
<211>  120
<212>  PRT
<213>  Lama glama

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser Ser Ser 
            20                  25                  30          


Val Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Ser Gly Ser Ser Thr Asp Ser Ala Lys Asp Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly 
                85                  90                  95      


Arg Ala Phe Leu Thr Arg Asp Pro Phe Tyr Tyr Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  43
<211>  116
<212>  PRT
<213>  Lama glama

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ile Ala Ser Gly Arg Asp Ile Phe Ser Val 
            20                  25                  30          


Thr Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe 
        35                  40                  45              


Val Ala Gly Leu Ser Asn Ile Gly Ala Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Gly Asp Ala Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Leu Leu Trp Ser Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  44
<211>  132
<212>  PRT
<213>  Lama glama

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Tyr Ile Ser Lys Ser Asp Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ser Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Pro Thr Leu Arg Val Arg Leu Asp Asn Asp Arg His His 
            100                 105                 110         


Leu Leu Tyr Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  45
<211>  132
<212>  PRT
<213>  Lama glama

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Val Thr Ser Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Pro Thr Leu Arg Val Arg Leu Asp Asn Asp Arg His His 
            100                 105                 110         


Leu Leu Tyr Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  46
<211>  124
<212>  PRT
<213>  Lama glama

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Ser Trp Asn Gly Gly Ser Thr Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Ala Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Ala Leu Val Gly Gly Val Thr Pro His Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  47
<211>  123
<212>  PRT
<213>  Lama glama

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Val Ile Trp Ser Ser Gly Asp Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Gly Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  48
<211>  123
<212>  PRT
<213>  Lama glama

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Gly Ile Trp Ser Ser Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  49
<211>  128
<212>  PRT
<213>  Lama glama

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser Glu Arg Thr Leu Pro Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Ser Gly Arg Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Glu Asn Thr Trp Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Ser Val Ser Glu Pro Thr Leu His Thr Trp Gln Tyr Glu 
            100                 105                 110         


Ala Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  50
<211>  124
<212>  PRT
<213>  Lama glama

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Val Pro Gly Glu Glu Arg Glu Phe Val 
        35                  40                  45              


Thr His Ile Thr Trp Asn Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Ile Lys Tyr Gly Glu Ile Thr His Pro Glu Glu Tyr Ser 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  51
<211>  121
<212>  PRT
<213>  Lama glama

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Asn 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Val Pro Gly Lys Ala Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Asn Val Gly Arg Leu Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Ala Gly Leu Val Tyr Ser Gly Ile Pro Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  52
<211>  124
<212>  PRT
<213>  Lama glama

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Thr His Ile Thr Trp Asn Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Ile Lys Tyr Gly Glu Ile Thr His Pro Glu Glu Tyr Ser 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  53
<211>  124
<212>  PRT
<213>  Lama glama

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Thr His Ile Thr Trp Asn Arg Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Ser Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Thr Lys Tyr Gly Glu Ile Thr Arg Pro Glu Glu Tyr Ser 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  54
<211>  115
<212>  PRT
<213>  Lama glama

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Val Cys Ser Ala Ser Gly Ile Asp Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Phe Met Ile Asn Asp Ser Ser Thr Asp Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Lys Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Thr Ala Tyr Glu Gln His Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  55
<211>  128
<212>  PRT
<213>  Lama glama

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Ile 
        35                  40                  45              


Ser Cys Ile Thr Pro Ser Asp Asp Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Arg Leu Arg Gly Leu Gly Tyr Trp Pro Tyr Pro Glu 
            100                 105                 110         


Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  56
<211>  124
<212>  PRT
<213>  Lama glama

<400>  56

Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Ala Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Cys Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  57
<211>  119
<212>  PRT
<213>  Lama glama

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Trp Asn Asp Glu Tyr Thr Tyr Tyr Ala Glu Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Ser Arg Leu Tyr Asp Tyr His Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  131
<212>  PRT
<213>  Lama glama

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Leu Arg Gly Arg Tyr Tyr Arg Gly Thr Tyr Ser Leu Val 
            100                 105                 110         


Cys Ala Pro Tyr Glu Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  59
<211>  131
<212>  PRT
<213>  Lama glama

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met His Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Leu Arg Gly Arg Tyr Tyr Ser Gly Ser Asn Tyr Leu Val 
            100                 105                 110         


Cys Ala Pro Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  60
<211>  125
<212>  PRT
<213>  Lama glama

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Ile Ile Ser Ser Lys Arg Leu Cys Leu Asp Leu Phe 
            100                 105                 110         


Gly Ser Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  61
<211>  125
<212>  PRT
<213>  Lama glama

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ile Thr Pro Cys Ser Asp Tyr Thr Gln Thr Tyr Glu Tyr 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  62
<211>  134
<212>  PRT
<213>  Lama glama

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Thr Ser Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Val Val Pro Ala Thr Arg Arg Asn Pro Gln Met Val Val Ala Lys 
            100                 105                 110         


Lys Cys Trp Leu Ala Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser 
    130                 


<210>  63
<211>  130
<212>  PRT
<213>  Lama glama

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Arg Ser Asp Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Gly Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Trp Ser Gly Ala Tyr Tyr Ser Gly Thr Tyr Tyr Cys Asp 
            100                 105                 110         


Arg Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  64
<211>  123
<212>  PRT
<213>  Lama glama

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Thr Met Trp Ser Ser Gly Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Gly Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Glu Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  65
<211>  127
<212>  PRT
<213>  Lama glama

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Leu Gly Tyr Gly Ser Ser Cys Arg Met Ala Pro Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  66
<211>  123
<212>  PRT
<213>  Lama glama

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Val Ile Trp Ser Ser Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  67
<211>  130
<212>  PRT
<213>  Lama glama

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ser Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Asn Arg Arg Ile Tyr Tyr Ser Asp Tyr Ala Leu Ala Cys 
            100                 105                 110         


Phe Pro Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  68
<211>  123
<212>  PRT
<213>  Lama glama

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Arg Arg Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Gly Ile Trp Ser Ser Gly Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  69
<211>  123
<212>  PRT
<213>  Lama glama

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Thr Met Trp Val Ser Gly Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Gly Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  70
<211>  123
<212>  PRT
<213>  Lama glama

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ile Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Ala Ile Trp Ser Ser Gly Asp Thr Ala Val Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Gly Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Glu Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  71
<211>  122
<212>  PRT
<213>  Lama glama

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Trp Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Ile Val Cys Gly Ser Tyr Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  72
<211>  123
<212>  PRT
<213>  Lama glama

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Gly Ile Trp Ser Ser Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Glu Arg Phe Thr Val Ser Arg Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Gln Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  73
<211>  128
<212>  PRT
<213>  Lama glama

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Trp Gly Ala Ser Arg Leu Pro Ile Gly Thr Met Pro Pro 
            100                 105                 110         


Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  74
<211>  118
<212>  PRT
<213>  Lama glama

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Val Cys Ser Ala Ser Gly Ile Asp Phe Ser Ile Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Gly Ser Gly Gly Ser Thr Asp Tyr Ile Asp Tyr Thr Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Lys Asn Ile 
65                  70                  75                  80  


Leu Tyr Leu Arg Met Asn Asn Leu Asn Val Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Ala Tyr Glu Gln His Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  75
<211>  125
<212>  PRT
<213>  Lama glama

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Leu Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Asn Gly Leu Gly Pro Phe Ser Val Pro Val Pro Val Tyr 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  76
<211>  130
<212>  PRT
<213>  Lama glama

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Pro Phe Asp Asp Tyr 
            20                  25                  30          


Val Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gly Pro Arg Ile Asn Ile Ala Thr Met Thr Cys Ser His 
            100                 105                 110         


Asp Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  77
<211>  133
<212>  PRT
<213>  Lama glama

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Glu Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Ala Gly Val Pro Ala Gly Pro Ala Ala Val Tyr Gly 
            100                 105                 110         


Ser Ser Cys Ser Arg Leu Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  78
<211>  124
<212>  PRT
<213>  Lama glama

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Arg Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Pro Tyr Ser Leu Ser Tyr Tyr Gly Tyr Pro Leu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  79
<211>  115
<212>  PRT
<213>  Lama glama

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Val Cys Ser Ala Ser Gly Ile Asp Phe Ser Ile Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Gly Ser Gly Ser Ser Thr Gly Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Ser Thr Lys Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Asn Val Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Thr Ala Tyr Glu Gln His Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  80
<211>  129
<212>  PRT
<213>  Lama glama

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Asp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  81
<211>  124
<212>  PRT
<213>  Lama glama

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ala Ala Ser Gly Pro Thr Phe Arg Ser Tyr 
            20                  25                  30          


Thr Met Ala Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Asp Ile Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Ser Leu Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Gln Ile Leu Arg Asp Asn Ala Lys Glu Thr Val Trp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ile Cys 
                85                  90                  95      


Ala Ala Ser Arg Ser Leu Asn Leu Ala Tyr Thr Thr Lys Pro Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  82
<211>  133
<212>  PRT
<213>  Lama glama

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Glu Asp Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Ile Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Pro Trp Thr Arg Arg Val Tyr Gly Ser Ser Trp Leu Ala 
            100                 105                 110         


Arg Ser Leu Asp Glu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  83
<211>  123
<212>  PRT
<213>  Lama glama

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Val Ile Trp Ser Ser Gly Asp Thr Ala Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Gly Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Glu Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  84
<211>  126
<212>  PRT
<213>  Lama glama

<400>  84

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ile Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Met Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  85
<211>  126
<212>  PRT
<213>  Lama glama

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ile Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Met Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  86
<211>  123
<212>  PRT
<213>  Lama glama

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Leu Met Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        35                  40                  45              


Ala Ala Val Ile Trp Ser Ser Gly Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Tyr Asp Gly Asn Tyr Tyr Ile Pro Gly Phe Tyr Lys Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  87
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  88
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Thr Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Lys Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  89
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Gln Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  90
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Val Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  91
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  92
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  93
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Phe Thr Leu Val Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  94
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  94

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  95
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  96
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Glu Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  97
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  97

Glu Val Gln Met Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  98
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  99
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  100
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Trp Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Met Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Ile Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  101
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Phe Leu Arg Leu Thr Cys Ala Val Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Val Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  102
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  102

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Ile Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  103
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  103

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Val Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  104
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Val Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  105
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Thr Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Ile Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  106
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  107
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Ser Thr Ile Ser Ser Asp Asn Ala Arg Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  108
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  108

Glu Glu Leu Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  109
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  110
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  111
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  112
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  113
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  114
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  115
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  116
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  117
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  118
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ile Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  119
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  119

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Ile Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  120
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  121
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  122
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Ile Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  123
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Ile Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  124
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Ala Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Cys Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  125
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  125

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Cys Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  126
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Ala Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Cys Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  127
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Cys Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  128
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Ala Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Cys Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  129
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Cys Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  130
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  130

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Cys Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  131
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  131

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ile Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Met Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  132
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Met Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  133
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Met Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  134
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Met Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  135
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  135

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Met Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  136
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Gln Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  137
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Arg Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  138
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Ser Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  139
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Gln Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  140
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Arg Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  141
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Ser Gly Leu Gly 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  142
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Thr Ile Arg Asp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  143
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  143

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Asp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  144
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  145
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  145

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  146
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  146

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  147
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  148
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  149
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  149

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  150
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  151
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  152
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  153
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  154
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Ile Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  155
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  156
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Asp Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  157
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Asp Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  158
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  159
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  159

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  160
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  160

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ser Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  161
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  162
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Glu Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  163
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  164
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Asp Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  165
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  165

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Glu Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  166
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  166

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Ile Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  167
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  167

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Ala Ile Arg Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro 
            100                 105                 110         


Leu Tyr Glu Tyr Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  168
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  168

Asp Tyr Ala Ile Gly 
1               5   


<210>  169
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  169

Asp Tyr Ala Leu Gly 
1               5   


<210>  170
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  170

Tyr Tyr Ala Ile Gly 
1               5   


<210>  171
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  171

Ala Ile Arg Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  172
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  172

Cys Ile Arg Cys Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  173
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  173

Cys Ile Ser Ser Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  174
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  174

Val Pro Ala Gly Arg Leu Arg Phe Gly Glu Gln Trp Tyr Pro Leu Tyr 
1               5                   10                  15      


Glu Tyr Asp Ala 
            20  


<210>  175
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  175

Val Pro Ala Gly Arg Leu Arg Tyr Gly Glu Gln Trp Tyr Pro Ile Tyr 
1               5                   10                  15      


Glu Tyr Asp Ala 
            20  


<210>  176
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  176

Ser Ile Val Pro Arg Ser Lys Leu Glu Pro Tyr Glu Tyr Asp Ala 
1               5                   10                  15  


<210>  177
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  177

Asp Ser Gly Gly Tyr Ile Asp Tyr Asp Cys Ser Gly Leu Gly Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  178
<211>  387
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  178
gaggtacagc tggtcgagtc aggtggcgga ttagtgcagc ctgggggttc tctgcgctta     60

tcttgtgccg catcaggctt cacactggat gactacgcca tcggctggtt ccggcaagcg    120

cctggaaaag aacgcgaagg tgtttcagca atccgttcaa gcggtggttc aacatattac    180

gccgactctg ttaaaggacg cttcaccatt agctccgaca atagtaaaaa tacagtctac    240

ttacaaatga acagtttacg cccagaagat actgcggtat actattgcgc tgccgtgcct    300

gctggtcgct tacgctttgg cgagcaatgg tatcctctgt acgagtacga cgcctgggga    360

cagggtacgc tggtaacggt ttcaagc                                        387


<210>  179
<211>  387
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  179
gaagtgcaac tggttgagtc aggtggcgga ctggtgcaac cgggtggttc actgcgcctg     60

agttgcgcag ttagcggtat taccctggat gattatgcaa ttggttggtt tcgccaagcc    120

ccaggcaaag agcgtgaagg cgttagcgca attcgtagca gcggtggtag cacctattat    180

gccgattcag ttaaaggccg ttttacgatc agcagcgata acagtaaaaa cacggtttat    240

ctgcaaatga actcattacg tccagaggac actgcagttt actattgcgc agcagttccg    300

gcaggtcgtc tgcgttatgg tgaacagtgg tatccgattt atgaatatga tgcatggggt    360

caaggtacac tggttacagt gagtagc                                        387


<210>  180
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  180
gaagtgcagt tagtcgaaag tggcggaggc ctggtacaac ctggtggcag tctgcgctta     60

tcttgtgccg cttcaggttt tacattcgac gactacgccc tggggtggtt ccggcaagcg    120

cctggaaaag aacgtgaggg cgtttcatgc attcgttgtt caggtggttc aacctattat    180

gccgatagtg taaaaggtcg gttcaccatt agtagcgaca atagcaagaa tacagtctat    240

ctgcaaatga actctttacg tcctgaagat actgcggtgt actactgcgc tgcatcaatc    300

gttcctcgtt caaaacttga accttacgag tacgacgcct ggggtcaggg tacgttagta    360

acggtgtcaa gc                                                        372


<210>  181
<211>  378
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated Lama sequence

<400>  181
gaagtgcaac tggttgagtc aggtggcggt ttagtgcaac cgggtggttc actgcgcctg     60

agttgcgcag ccagcggttt tgcactggat tattatgcaa ttggttggtt tcgccaagcc    120

ccaggcaaag agcgtgaagg cgttagctgt attagcagca gcggtggtat tacctattat    180

gccgattcag ttaaaggccg ttttacgatc tctcgtgata atagtaaaaa cacggtttac    240

ctgcagatga actcattaag accagaggac actgcagttt actattgtgc aaccgatagc    300

ggtggctata ttgattatga ttgtagcggt ctgggctacg attattgggg acaaggtacg    360

ctggtgacag ttagcagc                                                  378


<210>  182
<211>  3375
<212>  DNA
<213>  Homo sapiens

<400>  182
atggactctt tagccagctt agttctctgt ggagtcagct tgctcctttc tggaactgtg     60

gaaggtgcca tggacttgat cttgatcaat tccctacctc ttgtatctga tgctgaaaca    120

tctctcacct gcattgcctc tgggtggcgc ccccatgagc ccatcaccat aggaagggac    180

tttgaagcct taatgaacca gcaccaggat ccgctggaag ttactcaaga tgtgaccaga    240

gaatgggcta aaaaagttgt ttggaagaga gaaaaggcta gtaagatcaa tggtgcttat    300

ttctgtgaag ggcgagttcg aggagaggca atcaggatac gaaccatgaa gatgcgtcaa    360

caagcttcct tcctaccagc tactttaact atgactgtgg acaagggaga taacgtgaac    420

atatctttca aaaaggtatt gattaaagaa gaagatgcag tgatttacaa aaatggttcc    480

ttcatccatt cagtgccccg gcatgaagta cctgatattc tagaagtaca cctgcctcat    540

gctcagcccc aggatgctgg agtgtactcg gccaggtata taggaggaaa cctcttcacc    600

tcggccttca ccaggctgat agtccggaga tgtgaagccc agaagtgggg acctgaatgc    660

aaccatctct gtactgcttg tatgaacaat ggtgtctgcc atgaagatac tggagaatgc    720

atttgccctc ctgggtttat gggaaggacg tgtgagaagg cttgtgaact gcacacgttt    780

ggcagaactt gtaaagaaag gtgcagtgga caagagggat gcaagtctta tgtgttctgt    840

ctccctgacc cctatgggtg ttcctgtgcc acaggctgga agggtctgca gtgcaatgaa    900

gcatgccacc ctggttttta cgggccagat tgtaagctta ggtgcagctg caacaatggg    960

gagatgtgtg atcgcttcca aggatgtctc tgctctccag gatggcaggg gctccagtgt   1020

gagagagaag gcataccgag gatgacccca aagatagtgg atttgccaga tcatatagaa   1080

gtaaacagtg gtaaatttaa tcccatttgc aaagcttctg gctggccgct acctactaat   1140

gaagaaatga ccctggtgaa gccggatggg acagtgctcc atccaaaaga ctttaaccat   1200

acggatcatt tctcagtagc catattcacc atccaccgga tcctcccccc tgactcagga   1260

gtttgggtct gcagtgtgaa cacagtggct gggatggtgg aaaagccctt caacatttct   1320

gttaaagttc ttccaaagcc cctgaatgcc ccaaacgtga ttgacactgg acataacttt   1380

gctgtcatca acatcagctc tgagccttac tttggggatg gaccaatcaa atccaagaag   1440

cttctataca aacccgttaa tcactatgag gcttggcaac atattcaagt gacaaatgag   1500

attgttacac tcaactattt ggaacctcgg acagaatatg aactctgtgt gcaactggtc   1560

cgtcgtggag agggtgggga agggcatcct ggacctgtga gacgcttcac aacagcttct   1620

atcggactcc ctcctccaag aggtctaaat ctcctgccta aaagtcagac cactctaaat   1680

ttgacctggc aaccaatatt tccaagctcg gaagatgact tttatgttga agtggagaga   1740

aggtctgtgc aaaaaagtga tcagcagaat attaaagttc caggcaactt gacttcggtg   1800

ctacttaaca acttacatcc cagggagcag tacgtggtcc gagctagagt caacaccaag   1860

gcccaggggg aatggagtga agatctcact gcttggaccc ttagtgacat tcttcctcct   1920

caaccagaaa acatcaagat ttccaacatt acacactcct cggctgtgat ttcttggaca   1980

atattggatg gctattctat ttcttctatt actatccgtt acaaggttca aggcaagaat   2040

gaagaccagc acgttgatgt gaagataaag aatgccacca tcattcagta tcagctcaag   2100

ggcctagagc ctgaaacagc ataccaggtg gacatttttg cagagaacaa catagggtca   2160

agcaacccag ccttttctca tgaactggtg accctcccag aatctcaagc accagcggac   2220

ctcggagggg ggaagatgct gcttatagcc atccttggct ctgctggaat gacctgcctg   2280

actgtgctgt tggcctttct gatcatattg caattgaaga gggcaaatgt gcaaaggaga   2340

atggcccaag ccttccaaaa cgtgagggaa gaaccagctg tgcagttcaa ctcagggact   2400

ctggccctaa acaggaaggt caaaaacaac ccagatccta caatttatcc agtgcttgac   2460

tggaatgaca tcaaatttca agatgtgatt ggggagggca attttggcca agttcttaag   2520

gcgcgcatca agaaggatgg gttacggatg gatgctgcca tcaaaagaat gaaagaatat   2580

gcctccaaag atgatcacag ggactttgca ggagaactgg aagttctttg taaacttgga   2640

caccatccaa acatcatcaa tctcttagga gcatgtgaac atcgaggcta cttgtacctg   2700

gccattgagt acgcgcccca tggaaacctt ctggacttcc ttcgcaagag ccgtgtgctg   2760

gagacggacc cagcatttgc cattgccaat agcaccgcgt ccacactgtc ctcccagcag   2820

ctccttcact tcgctgccga cgtggcccgg ggcatggact acttgagcca aaaacagttt   2880

atccacaggg atctggctgc cagaaacatt ttagttggtg aaaactatgt ggcaaaaata   2940

gcagattttg gattgtcccg aggtcaagag gtgtacgtga aaaagacaat gggaaggctc   3000

ccagtgcgct ggatggccat cgagtcactg aattacagtg tgtacacaac caacagtgat   3060

gtatggtcct atggtgtgtt actatgggag attgttagct taggaggcac accctactgc   3120

gggatgactt gtgcagaact ctacgagaag ctgccccagg gctacagact ggagaagccc   3180

ctgaactgtg atgatgaggt gtatgatcta atgagacaat gctggcggga gaagccttat   3240

gagaggccat catttgccca gatattggtg tccttaaaca gaatgttaga ggagcgaaag   3300

acctacgtga ataccacgct ttatgagaag tttacttatg caggaattga ctgttctgct   3360

gaagaagcgg cctag                                                    3375


<210>  183
<211>  4654
<212>  DNA
<213>  Mouse

<400>  183
gagcaggagc cggagcagga gcagaagata agccttggat gaagggcaag atggataggg     60

ctcgctctgc cccaagccct gctgatacca agtgccttta agatacagcc tttcccatcc    120

taatctgcaa aggaaacagg aaaaaggaac ttaaccctcc ctgtgctcag acagaaatga    180

gactgttacc gcctgcttct gtggtgtttc tccttgccgc caacttgtaa acaagagcga    240

gtggaccatg cgagcgggaa gtcgcaaagt tgtgagttgt tgaaagcttc ccagggactc    300

atgctcatct gtggacgctg gatggggaga tctggggaag tatggactct ttagccggct    360

tagttctctg tggagtcagc ttgctccttt atggagtagt agaaggcgcc atggacctga    420

tcttgatcaa ttccctacct cttgtgtctg atgccgaaac atccctcacc tgcattgcct    480

ctgggtggca cccccatgag cccatcacca taggaaggga ctttgaagcc ttaatgaacc    540

agcaccaaga tccactggag gttactcaag atgtgaccag agaatgggcg aaaaaagttg    600

tttggaagag agaaaaggcc agtaagatta atggtgctta tttctgtgaa ggtcgagttc    660

gaggacaggc tataaggata cggaccatga agatgcgtca acaagcatcc ttcctacctg    720

ctactttaac tatgaccgtg gacaggggag ataatgtgaa catatctttc aaaaaggtgt    780

taattaaaga agaagatgca gtgatttaca aaaatggctc cttcatccac tcagtgcccc    840

ggcatgaagt acctgatatt ttagaagttc acttgccgca tgctcagccc caggatgctg    900

gtgtgtactc ggccaggtac ataggaggaa acctgttcac ctcagccttc accaggctga    960

ttgttcggag atgtgaagct cagaagtggg ggcccgactg tagccgtcct tgtactactt   1020

gcaagaacaa tggagtctgc catgaagata ccggggaatg catttgccct cctgggttta   1080

tggggagaac atgtgagaaa gcttgtgagc cgcacacatt tggcaggacc tgtaaagaaa   1140

ggtgtagtgg accagaagga tgcaagtctt atgtgttctg tctcccagac ccttacgggt   1200

gttcctgtgc cacaggctgg agggggttgc agtgcaatga agcatgccca tctggttact   1260

acggaccaga ctgtaagctc aggtgccact gtaccaatga agagatatgt gatcggttcc   1320

aaggatgcct ctgctctcaa ggatggcaag ggctgcagtg tgagaaagaa ggcaggccaa   1380

ggatgactcc acagatagag gatttgccag atcacattga agtaaacagt ggaaaattta   1440

accccatctg caaagcctct gggtggccac tacctactag tgaagaaatg accctagtga   1500

agccagatgg gacagtgctc caaccaaatg acttcaacta tacagatcgt ttctcagtgg   1560

ccatattcac tgtcaaccga gtcttacctc ctgactcagg agtctgggtc tgcagtgtga   1620

acacagtggc tgggatggtg gaaaagcctt tcaacatttc cgtcaaagtt cttccagagc   1680

ccctgcacgc cccaaatgtg attgacactg gacataactt tgctatcatc aatatcagct   1740

ctgagcctta ctttggggat ggacccatca aatccaagaa gcttttctat aaacctgtca   1800

atcaggcctg gaaatacatt gaagtgacga atgagatttt cactctcaac tacttggagc   1860

cgcggactga ctacgagctg tgtgtgcagc tggcccgtcc tggagagggt ggagaagggc   1920

atcctgggcc tgtgagacga tttacaacag cgtctatcgg actccctcct ccaagaggtc   1980

tcagtctcct gccaaaaagc cagacagctc taaatttgac ttggcaaccg atatttacaa   2040

actcagaaga tgaattttat gtggaagtcg agaggcgatc cctgcaaaca acaagtgatc   2100

agcagaacat caaagtgcct gggaacctga cctcggtgct actgagcaac ttagtcccca   2160

gggagcagta cacagtccga gctagagtca acaccaaggc gcagggggag tggagtgaag   2220

aactcagggc ctggaccctt agtgacattc tccctcctca accagaaaac atcaagatct   2280

ccaacatcac tgactccaca gctatggttt cttggacaat agtggatggc tattcgattt   2340

cttccatcat catccggtat aaggttcagg gcaaaaatga agaccagcac attgatgtga   2400

agatcaagaa tgctaccgtt actcagtacc agctcaaggg cctagagcca gagactacat   2460

accatgtgga tatttttgct gagaacaaca taggatcaag caacccagcc ttttctcatg   2520

aactgaggac gcttccacat tccccagcct ctgcagacct cggaggggga aagatgctac   2580

tcatagccat ccttgggtcg gctggaatga cttgcatcac cgtgctgttg gcgtttctga   2640

ttatgttgca actgaagaga gcaaatgtcc aaaggagaat ggctcaggca ttccagaacg   2700

tgagagaaga accagctgtg cagtttaact caggaactct ggcccttaac aggaaggcca   2760

aaaacaatcc ggatcccaca atttatcctg tgcttgactg gaatgacatc aagtttcaag   2820

acgtgatcgg agagggcaac tttggccagg ttctgaaggc acgcatcaag aaggatgggt   2880

tacggatgga tgccgccatc aagaggatga aagagtatgc ctccaaagat gatcacaggg   2940

acttcgcagg agaactggag gttctttgta aacttggaca ccatccaaac atcattaatc   3000

tcttgggagc atgtgaacac cgaggctatt tgtacctagc tattgagtat gccccgcatg   3060

gaaacctcct ggacttcctg cgtaagagca gagtgctaga gacagaccct gcttttgcca   3120

tcgccaacag tacagcttcc acactgtcct cccaacagct tcttcatttt gctgcagatg   3180

tggcccgggg gatggactac ttgagccaga aacagtttat ccacagggac ctggctgcca   3240

gaaacatttt agttggtgaa aactacatag ccaaaatagc agattttgga ttgtcacgag   3300

gtcaagaagt gtatgtgaaa aagacaatgg gaaggctccc agtgcgttgg atggcaatcg   3360

aatcactgaa ctatagtgtc tatacaacca acagtgatgt ctggtcctat ggtgtattgc   3420

tctgggagat tgttagctta ggaggcaccc cctactgcgg catgacgtgc gcggagctct   3480

atgagaagct accccagggc tacaggctgg agaagcccct gaactgtgat gatgaggtgt   3540

atgatctaat gagacagtgc tggagggaga agccttatga gagaccatca tttgcccaga   3600

tattggtgtc cttaaacagg atgctggaag aacggaagac atacgtgaac accacactgt   3660

atgagaagtt tacctatgca ggaattgact gctctgcgga agaagcagcc tagagcagaa   3720

ctcttcatgt acaacggcca tttctcctca ctggcgcgag agcgccttga cacctgtacc   3780

aagcaagcca cccactgcca agagatgtga tatataagtg tatatattgt gctgtgtttg   3840

ggaccctcct catacagctc gtgcggatct gcagtgtgtt ctgactctaa tgtgactgta   3900

tatactgctc ggagtaagaa tgtgctaaga tcagaatgcc tgttcgtggt ttcatataat   3960

atatttttct aaaagcatag attgcacagg aaggtatgag tacaaatact gtaatgcata   4020

acttgttatt gtcctagatg tgtttgatat ttttccttta caactgaatg ctataaaagt   4080

gttttgctgt gtacacataa gatactgttc gttaaaataa gcattccctt gacagcacag   4140

gaagaaaagc gagggaaatg tatggattat attaaatgtg ggttactaca caagaggccg   4200

aacattccaa gtagcagaag agagggtctc tcaactctgc tcctcacctg cagaagccag   4260

tttgtttggc catgtgacaa ttgtcctgtg tttttatagc acccaaatca ttctaaaata   4320

tgaacatcta aaaactttgc taggagacta agaacctttg gagagataga tataagtacg   4380

gtcaaaaaac aaaactgtgg gacttacatt tattttctat agtaatctgt tgtacatttt   4440

aagaagtaaa actaggaatt taggagtgat gtgtgacatt tctgacatgg agttaccatc   4500

cccacatgta tcacatactg tcatattccc acatgtatca cacatgtatt gtaaaatttt   4560

gtagttttga tcacttgtga atttactgtt gatgtggtag ccacctgctg caatggttcc   4620

tcttgtaggt gaataaatgt cttgtctacc caca                               4654


<210>  184
<211>  3378
<212>  DNA
<213>  Artificial

<220>
<223>  Mutated Cyno sequence

<400>  184
atggacagcc tggccagcct ggtgctgtgc ggagtgtccc tgctgctgag cggcacagtg     60

gaaggcgcca tggacctgat cctgatcaac tccctgcccc tggtgtccga cgccgagaca    120

agcctgacct gtatcgctag cggctggcac ccccacgagc ctatcaccat cggccgggac    180

ttcgaggccc tgatgaacca gcaccaggac cccctggaag tgacccagga cgtgacccgc    240

gagtgggcca agaaagtcgt gtggaagaga gagaaggcca gcaagatcaa cggcgcctac    300

ttctgcgagg gcagagtgcg gggcgaggcc atcagaatcc ggacaatgaa gatgcggcag    360

caggccagct tcctgcccgc caccctgacc atgaccgtgg acaagggcga caacgtgaac    420

atcagcttca agaaggtgct gatcaaagaa gaggacgccg tcatctacaa gaacggcagc    480

ttcatccaca gcgtgccccg gcacgaggtg cccgacatcc tggaagtgca tctgccccac    540

gcccagcctc aggatgccgg cgtgtacagc gcccggtaca tcggcggcaa cctgttcacc    600

agcgccttca cccggctgat cgtgcggaga tgcgaggccc agaaatgggg ccctgagtgt    660

aaccggctgt gcaccgtgtg cgtgaacaac ggcgtgtgcc acgaggacac cggcgagtgc    720

atctgtcctc ccggcttcat gggccggacc tgcgagaagg cctgcgagag acacaccttc    780

ggcagaacct gcaaagagcg gtgtagcggc caggacggct gcaagagcta cgtgttctgc    840

ctgcccgacc cctacggctg cagctgtgcc acaggctgga agggcctgca gtgcaacgag    900

gcctgccacc acggcttcta cggccccgac tgcaagctgc ggtgcagctg cagcaacggc    960

gagacatgcg accggttcca gggatgcctg tgcagccctg gcagacaggg actccagtgc   1020

gagcgcgagg gcatccccag aatgaccccc aagatcgtgg acctgcccga tcacatcgaa   1080

gtgaacagcg gcaagttcaa ccccatctgc aaggcctccg gctggcccct gcccaccaac   1140

gaagagatga ccctggtcaa gcccgacggc accgtgctgc accccaagga cttcaaccac   1200

accgaccact tcagcgtggc catcttcacc atccaccgga tcctgccccc cgactctggc   1260

gtgtgggtct gcagcgccaa taccgtggcc ggcatggtgg aaaagccctt caacatcagc   1320

gtgaaggtgc tgcccaagcc cctgaacgcc cccaacgtga tcgacaccgg ccacaacttc   1380

gccgtgatca acatctccag cgagccctac ttcggcgacg gccccatcaa gagcaagaag   1440

ctgctgtaca agcccgtgaa ccactacgag gcctggcggc acatccaggt cacaaacgag   1500

atcgtgaccc tgaaccacct ggaaccccgg accgagtacg agctgtgcgt gcagctcgtg   1560

cggaggggcg aaggcggcga aggacatcct ggccccgtgc gcagattcac caccgcctct   1620

atcggcctgc ccccacccag aggcctgaac ctgctgccta agagccagac caccctgaac   1680

ctgacctggc agcccatctt ccccagcagc gaggacgact tctacgtgga agtggaacgg   1740

cggagcgtgc agaagtccga ccagcagaac atcaaggtgc ccggcaacct gaccagcgtg   1800

ctgctgaaca acctgcaccc ccgcgagcag tacgtcgtgc gggccagagt gaacaccaag   1860

gcccagggcg agtggtccga ggatctgacc gcctggaccc tgagcgacat cctgcctccc   1920

cagcccgaga atatcaaaat cagcaacatc acccacagca gcgccgtgat ctcttggacc   1980

atcctggacg gctacagcat cagctccatc accatccggt acaaggtgca gggcaagaac   2040

gaggaccagc acatcgacgt gaagatcaag aacgccacca tcacccagta ccagctgaag   2100

ggcctggaac ccgagacagc ctaccaggtg gacatcttcg ccgagaacaa tatcggcagc   2160

agcaaccccg ccttcagcca cgagctggtc accctgcccg agtctgaggc ccctgctgat   2220

ctgggcggag gcaagatgct gctgatcgcc atcctgggca gcgccggcat gacctgtctg   2280

acagtgctgc tggccttcct gatcatcctg cagctgaagc gggccaacgt gcagcggaga   2340

atggcccagg ccttccagaa cgtgcgcgag gaacccgccg tgcagttcaa cagcggcacc   2400

ctggccctga accggaaagt gaagaacaac cccgacccca ccatctaccc cgtgctggac   2460

tggaacgaca tcaagttcca ggatgtgatc ggcgagggca acttcggcca ggtgctgaag   2520

gcccggatca agaaagacgg cctgcggatg gacgccgcca tcaagcggat gaaggaatac   2580

gccagcaagg acgaccacag agacttcgcc ggggagctgg aagtgctgtg caagctgggc   2640

caccacccca acatcatcaa cctgctgggc gcctgcgagc accggggcta tctgtacctg   2700

gccatcgagt acgcccccca cggcaatctg ctggatttcc tgcggaagtc ccgggtgctg   2760

gaaaccgacc ctgccttcgc cattgccaac agcaccgcca gcaccctgag cagccagcag   2820

ctcctgcact tcgccgccga tgtggccaga ggcatggact acctgagcca gaagcagttc   2880

atccaccggg acctggccgc cagaaacatc ctcgtgggcg agaactacgt ggccaagatc   2940

gccgacttcg gcctgagcag aggccaggaa gtgtacgtca agaaaaccat gggccggctg   3000

cccgtgcggt ggatggccat tgagagcctg aactacagcg tgtacaccac caacagcgac   3060

gtgtggtcct acggggtgct gctgtgggag atcgtgtctc tgggcggcac cccctactgc   3120

ggcatgacat gcgccgagct gtacgagaag ctgccccagg gctaccggct ggaaaagcct   3180

ctgaactgcg acgacgaggt gttcgacctg atgcggcagt gctggcgcga gaagccctac   3240

gagcggccta gcttcgccca gatcctggtg tccctgaaca gaatgctgga agaacgcaag   3300

acctacgtga acaccaccct gtatgagaag ttcacctacg ccggcatcga ctgcagcgcc   3360

gaagaggccg cttgatga                                                 3378


<210>  185
<211>  1491
<212>  DNA
<213>  Mouse

<400>  185
atgtggcaga tcattttcct aacttttggc tgggatcttg tcttggcctc agcctacagt     60

aactttagga agagcgtgga cagcacaggc agaaggcagt accaggtcca gaacggaccc    120

tgcagctaca cgttcctgct gccggagacc gacagctgcc gatcttcctc cagcccctac    180

atgtccaatg ccgtgcagag ggatgcaccc ctcgactacg acgactcagt gcaaaggctg    240

caggtgctgg agaacattct agagaacaac acacagtggc tgatgaagct ggagaattac    300

attcaggaca acatgaagaa ggagatggtg gagatccaac agaatgtggt gcagaaccag    360

acagctgtga tgatagagat tggaaccagc ttgctgaacc agacagcagc acaaactcgg    420

aaactgactg atgtggaagc ccaagtacta aaccagacga caagactcga gctgcagctt    480

ctccaacatt ctatttctac caacaaattg gaaaagcaga ttttggatca gaccagtgaa    540

ataaacaagc tacaaaataa gaacagcttc ctagaacaga aagttctgga catggagggc    600

aagcacagcg agcagctaca gtccatgaag gagcagaagg acgagctcca ggtgctggtg    660

tccaagcaga gctctgtcat tgacgagctg gagaagaagc tggtgacagc cacggtcaac    720

aactcgctcc ttcagaagca gcagcatgac ctaatggaga ccgtcaacag cttgctgacc    780

atgatgtcat cacccaactc caagagctcg gttgctatcc gtaaagaaga gcaaaccacc    840

ttcagagact gtgcggaaat cttcaagtca ggactcacca ccagtggcat ctacacactg    900

accttcccca actccacaga ggagatcaag gcctactgtg acatggacgt gggtggagga    960

gggtggacag tcatccaaca ccgagaagat ggcagtgtgg acttccagag gacgtggaaa   1020

gaatacaaag agggcttcgg gagccctctg ggagagtact ggctgggcaa tgagtttgtc   1080

tcccagctga ccggtcagca ccgctacgtg cttaagatcc agctgaagga ctgggaaggc   1140

aacgaggcgc attcgctgta tgatcacttc tacctcgctg gtgaagagtc caactacagg   1200

attcacctta caggactcac ggggaccgcg ggcaaaataa gtagcatcag ccaaccagga   1260

agtgatttta gcacaaagga ttcggacaat gacaaatgca tctgcaagtg ttcccagatg   1320

ctctcaggag gctggtggtt tgacgcatgt ggtccttcca acttgaatgg acagtactac   1380

ccacaaaaac agaatacaaa taagtttaac ggtatcaagt ggtactactg gaaggggtcc   1440

ggctactcgc tcaaggccac aaccatgatg atccggccag cagatttcta a            1491


<210>  186
<211>  1488
<212>  DNA
<213>  Cyno

<400>  186
atgtggcaga ttgttttctt taccctgagc tgtgatcttg tcttggccgc agcctataac     60

aactttcgga agagcatgga cagcatagga aagaagcagt atcaggtcca gcatgggtcc    120

tgcagctaca ctttcctcct gccagagatg gacaactgcc gctcttcctc cagcccctac    180

gtgtccaatg ctgtgcagag ggacgcgccg ctagaatatg atgactcggt gcagaggctg    240

caagtgctgg agaacatcat ggaaaacaac actcagtggc taatgaagct tgagaattat    300

atccaggaca acatgaaaaa agaaatggta gagatacagc agaacgcagt acagaaccag    360

acggctgtga tgatagaagt agtgacgaac ctgttgaacc aaacggcgga gcaaacgcgg    420

aagttaactg atgtggaagc ccaagtatta aaccagacca caagacttga acttcagctc    480

ttggaacact ccctctcgac aaacaaattg gaaaaacaga ttttggacca gaccagtgaa    540

ataaacaaat tgcaagataa gaacagtttc ctagaaaaga aggtgctagc tatggaagac    600

aagcacatca tccaactaca gtcaatcaaa gaagagaaag atcagctgca ggtgttagta    660

tccaagcaaa attccatcat tgaagaacta gaaaaaaaaa tagtgactgc cacggtgaat    720

aattcagttc ttcagaagca gcaacatgat ctcatggaga cagttaataa cttactgact    780

atgatgtcca catcaaactc taaggacccc actgttgcta aggaagaaca aatcagcttc    840

agagactgtg ctgaagtgtt caaatcagga cacaccacga atggcgtcta cacgttaaca    900

ctccccaact ctacagaaga ggtcaaggcc tactgtgaca tggaagctgg tggaggcggg    960

tggacaatta ttcagcgacg tgaggacggc agcgttgact ttcagaggac ttggaaagaa   1020

tataaagtgg gatttggtaa cccttcagga gaatattggc tgggaaatga gtttgtttca   1080

caactgacta atcagcaacg ctatgtgctt aaaatacacc ttaaagactg ggaagggaac   1140

gaggcttact cattgtatga acatttctat ctctcaagtg aagaactcaa ttataggatt   1200

caccttaaag gacttacagg gacagccggc aaaataagca gcatcagtca accaggaaat   1260

gattttagca caaaggatgc agacaacgac aaatgtattt gcaaatgttc acaaatgcta   1320

acaggaggct ggtggtttga tgcatgtggt ccttccaact tgaacggaat gtactatcca   1380

caaaggcaga acacaaataa gttcaacggc attaagtggt actactggaa aggctcaggc   1440

tactcgctca agggcacaac catgatgatc cgaccggcag atttctaa                1488


<210>  187
<211>  495
<212>  PRT
<213>  Cyno

<400>  187

Met Trp Gln Ile Val Phe Phe Thr Leu Ser Cys Asp Leu Val Leu Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Phe Arg Lys Ser Met Asp Ser Ile Gly Lys Lys 
            20                  25                  30          


Gln Tyr Gln Val Gln His Gly Ser Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Met Asp Asn Cys Arg Ser Ser Ser Ser Pro Tyr Val Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Glu Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Met Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Ala Val Gln Asn Gln Thr Ala Val Met Ile Glu Val Val 
        115                 120                 125             


Thr Asn Leu Leu Asn Gln Thr Ala Glu Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Glu His Ser Leu Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asp Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Lys Lys Val Leu Ala Met Glu Asp Lys His Ile Ile Gln Leu Gln Ser 
        195                 200                 205             


Ile Lys Glu Glu Lys Asp Gln Leu Gln Val Leu Val Ser Lys Gln Asn 
    210                 215                 220                 


Ser Ile Ile Glu Glu Leu Glu Lys Lys Ile Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Val Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Asn Leu Leu Thr Met Met Ser Thr Ser Asn Ser Lys Asp Pro Thr Val 
            260                 265                 270         


Ala Lys Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys 
        275                 280                 285             


Ser Gly His Thr Thr Asn Gly Val Tyr Thr Leu Thr Leu Pro Asn Ser 
    290                 295                 300                 


Thr Glu Glu Val Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly 
305                 310                 315                 320 


Trp Thr Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg 
                325                 330                 335     


Thr Trp Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr 
            340                 345                 350         


Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr 
        355                 360                 365             


Val Leu Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser 
    370                 375                 380                 


Leu Tyr Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile 
385                 390                 395                 400 


His Leu Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser 
                405                 410                 415     


Gln Pro Gly Asn Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp Lys Cys 
            420                 425                 430         


Ile Cys Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala 
        435                 440                 445             


Cys Gly Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn 
    450                 455                 460                 


Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly 
465                 470                 475                 480 


Tyr Ser Leu Lys Gly Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495 


<210>  188
<211>  496
<212>  PRT
<213>  Mouse

<400>  188

Met Trp Gln Ile Ile Phe Leu Thr Phe Gly Trp Asp Leu Val Leu Ala 
1               5                   10                  15      


Ser Ala Tyr Ser Asn Phe Arg Lys Ser Val Asp Ser Thr Gly Arg Arg 
            20                  25                  30          


Gln Tyr Gln Val Gln Asn Gly Pro Cys Ser Tyr Thr Phe Leu Leu Pro 
        35                  40                  45              


Glu Thr Asp Ser Cys Arg Ser Ser Ser Ser Pro Tyr Met Ser Asn Ala 
    50                  55                  60                  


Val Gln Arg Asp Ala Pro Leu Asp Tyr Asp Asp Ser Val Gln Arg Leu 
65                  70                  75                  80  


Gln Val Leu Glu Asn Ile Leu Glu Asn Asn Thr Gln Trp Leu Met Lys 
                85                  90                  95      


Leu Glu Asn Tyr Ile Gln Asp Asn Met Lys Lys Glu Met Val Glu Ile 
            100                 105                 110         


Gln Gln Asn Val Val Gln Asn Gln Thr Ala Val Met Ile Glu Ile Gly 
        115                 120                 125             


Thr Ser Leu Leu Asn Gln Thr Ala Ala Gln Thr Arg Lys Leu Thr Asp 
    130                 135                 140                 


Val Glu Ala Gln Val Leu Asn Gln Thr Thr Arg Leu Glu Leu Gln Leu 
145                 150                 155                 160 


Leu Gln His Ser Ile Ser Thr Asn Lys Leu Glu Lys Gln Ile Leu Asp 
                165                 170                 175     


Gln Thr Ser Glu Ile Asn Lys Leu Gln Asn Lys Asn Ser Phe Leu Glu 
            180                 185                 190         


Gln Lys Val Leu Asp Met Glu Gly Lys His Ser Glu Gln Leu Gln Ser 
        195                 200                 205             


Met Lys Glu Gln Lys Asp Glu Leu Gln Val Leu Val Ser Lys Gln Ser 
    210                 215                 220                 


Ser Val Ile Asp Glu Leu Glu Lys Lys Leu Val Thr Ala Thr Val Asn 
225                 230                 235                 240 


Asn Ser Leu Leu Gln Lys Gln Gln His Asp Leu Met Glu Thr Val Asn 
                245                 250                 255     


Ser Leu Leu Thr Met Met Ser Ser Pro Asn Ser Lys Ser Ser Val Ala 
            260                 265                 270         


Ile Arg Lys Glu Glu Gln Thr Thr Phe Arg Asp Cys Ala Glu Ile Phe 
        275                 280                 285             


Lys Ser Gly Leu Thr Thr Ser Gly Ile Tyr Thr Leu Thr Phe Pro Asn 
    290                 295                 300                 


Ser Thr Glu Glu Ile Lys Ala Tyr Cys Asp Met Asp Val Gly Gly Gly 
305                 310                 315                 320 


Gly Trp Thr Val Ile Gln His Arg Glu Asp Gly Ser Val Asp Phe Gln 
                325                 330                 335     


Arg Thr Trp Lys Glu Tyr Lys Glu Gly Phe Gly Ser Pro Leu Gly Glu 
            340                 345                 350         


Tyr Trp Leu Gly Asn Glu Phe Val Ser Gln Leu Thr Gly Gln His Arg 
        355                 360                 365             


Tyr Val Leu Lys Ile Gln Leu Lys Asp Trp Glu Gly Asn Glu Ala His 
    370                 375                 380                 


Ser Leu Tyr Asp His Phe Tyr Leu Ala Gly Glu Glu Ser Asn Tyr Arg 
385                 390                 395                 400 


Ile His Leu Thr Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile 
                405                 410                 415     


Ser Gln Pro Gly Ser Asp Phe Ser Thr Lys Asp Ser Asp Asn Asp Lys 
            420                 425                 430         


Cys Ile Cys Lys Cys Ser Gln Met Leu Ser Gly Gly Trp Trp Phe Asp 
        435                 440                 445             


Ala Cys Gly Pro Ser Asn Leu Asn Gly Gln Tyr Tyr Pro Gln Lys Gln 
    450                 455                 460                 


Asn Thr Asn Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser 
465                 470                 475                 480 


Gly Tyr Ser Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                485                 490                 495     


<210>  189
<211>  253
<212>  PRT
<213>  Mouse

<400>  189

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ile Leu 
            20                  25                  30          


Glu Glu Gln Thr Thr Phe Arg Asp Cys Ala Glu Ile Phe Lys Ser Gly 
        35                  40                  45              


Leu Thr Thr Ser Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu 
    50                  55                  60                  


Glu Ile Lys Ala Tyr Cys Asp Met Asp Val Gly Gly Gly Gly Trp Thr 
65                  70                  75                  80  


Val Ile Gln His Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp 
                85                  90                  95      


Lys Glu Tyr Lys Glu Gly Phe Gly Ser Pro Leu Gly Glu Tyr Trp Leu 
            100                 105                 110         


Gly Asn Glu Phe Val Ser Gln Leu Thr Gly Gln His Arg Tyr Val Leu 
        115                 120                 125             


Lys Ile Gln Leu Lys Asp Trp Glu Gly Asn Glu Ala His Ser Leu Tyr 
    130                 135                 140                 


Asp His Phe Tyr Leu Ala Gly Glu Glu Ser Asn Tyr Arg Ile His Leu 
145                 150                 155                 160 


Thr Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro 
                165                 170                 175     


Gly Ser Asp Phe Ser Thr Lys Asp Ser Asp Asn Asp Lys Cys Ile Cys 
            180                 185                 190         


Lys Cys Ser Gln Met Leu Ser Gly Gly Trp Trp Phe Asp Ala Cys Gly 
        195                 200                 205             


Pro Ser Asn Leu Asn Gly Gln Tyr Tyr Pro Gln Lys Gln Asn Thr Asn 
    210                 215                 220                 


Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser 
225                 230                 235                 240 


Leu Lys Ala Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                245                 250             


<210>  190
<211>  253
<212>  PRT
<213>  Cyno

<400>  190

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ile Leu 
            20                  25                  30          


Glu Glu Gln Ile Ser Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly 
        35                  40                  45              


His Thr Thr Asn Gly Val Tyr Thr Leu Thr Leu Pro Asn Ser Thr Glu 
    50                  55                  60                  


Glu Val Lys Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr 
65                  70                  75                  80  


Ile Ile Gln Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp 
                85                  90                  95      


Lys Glu Tyr Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu 
            100                 105                 110         


Gly Asn Glu Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu 
        115                 120                 125             


Lys Ile His Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr 
    130                 135                 140                 


Glu His Phe Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu 
145                 150                 155                 160 


Lys Gly Leu Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro 
                165                 170                 175     


Gly Asn Asp Phe Ser Thr Lys Asp Ala Asp Asn Asp Lys Cys Ile Cys 
            180                 185                 190         


Lys Cys Ser Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly 
        195                 200                 205             


Pro Ser Asn Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn 
    210                 215                 220                 


Lys Phe Asn Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser 
225                 230                 235                 240 


Leu Lys Gly Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
                245                 250             


