                         SEQUENCE LISTING

<110>  Lindhout, Darrin A.
       Zhang, Peng
       Parsons, Thomas F.
 
<120>  COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC  DISORDERS

<130>  NGMB-0126WO

<150>  US 61/616,294
<151>  2012-03-27

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Gly Gln Glu Leu Arg Thr Val Asn Gly Ser Gln Met Leu Leu 
1               5                   10                  15      


Val Leu Leu Val Leu Ser Trp Leu Pro His Gly Gly Ala Leu Ser Leu 
            20                  25                  30          


Ala Glu Ala Ser Arg Ala Ser Phe Pro Gly Pro Ser Glu Leu His Ser 
        35                  40                  45              


Glu Asp Ser Arg Phe Arg Glu Leu Arg Lys Arg Tyr Glu Asp Leu Leu 
    50                  55                  60                  


Thr Arg Leu Arg Ala Asn Gln Ser Trp Glu Asp Ser Asn Thr Asp Leu 
65                  70                  75                  80  


Val Pro Ala Pro Ala Val Arg Ile Leu Thr Pro Glu Val Arg Leu Gly 
                85                  90                  95      


Ser Gly Gly His Leu His Leu Arg Ile Ser Arg Ala Ala Leu Pro Glu 
            100                 105                 110         


Gly Leu Pro Glu Ala Ser Arg Leu His Arg Ala Leu Phe Arg Leu Ser 
        115                 120                 125             


Pro Thr Ala Ser Arg Ser Trp Asp Val Thr Arg Pro Leu Arg Arg Gln 
    130                 135                 140                 


Leu Ser Leu Ala Arg Pro Gln Ala Pro Ala Leu His Leu Arg Leu Ser 
145                 150                 155                 160 


Pro Pro Pro Ser Gln Ser Asp Gln Leu Leu Ala Glu Ser Ser Ser Ala 
                165                 170                 175     


Arg Pro Gln Leu Glu Leu His Leu Arg Pro Gln Ala Ala Arg Gly Arg 
            180                 185                 190         


Arg Arg Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly 
        195                 200                 205             


Arg Cys Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly 
    210                 215                 220                 


Trp Ala Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys 
225                 230                 235                 240 


Ile Gly Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln 
                245                 250                 255     


Ile Lys Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro 
            260                 265                 270         


Cys Cys Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr 
        275                 280                 285             


Asp Thr Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp 
    290                 295                 300                 


Cys His Cys Ile 
305             


<210>  2
<211>  1220
<212>  DNA
<213>  Homo sapiens

<400>  2
agtcccagct cagagccgca acctgcacag ccatgcccgg gcaagaactc aggacggtga       60

atggctctca gatgctcctg gtgttgctgg tgctctcgtg gctgccgcat gggggcgccc      120

tgtctctggc cgaggcgagc cgcgcaagtt tcccgggacc ctcagagttg cactccgaag      180

actccagatt ccgagagttg cggaaacgct acgaggacct gctaaccagg ctgcgggcca      240

accagagctg ggaagattcg aacaccgacc tcgtcccggc ccctgcagtc cggatactca      300

cgccagaagt gcggctggga tccggcggcc acctgcacct gcgtatctct cgggccgccc      360

ttcccgaggg gctccccgag gcctcccgcc ttcaccgggc tctgttccgg ctgtccccga      420

cggcgtcaag gtcgtgggac gtgacacgac cgctgcggcg tcagctcagc cttgcaagac      480

cccaggcgcc cgcgctgcac ctgcgactgt cgccgccgcc gtcgcagtcg gaccaactgc      540

tggcagaatc ttcgtccgca cggccccagc tggagttgca cttgcggccg caagccgcca      600

gggggcgccg cagagcgcgt gcgcgcaacg gggaccactg tccgctcggg cccgggcgtt      660

gctgccgtct gcacacggtc cgcgcgtcgc tggaagacct gggctgggcc gattgggtgc      720

tgtcgccacg ggaggtgcaa gtgaccatgt gcatcggcgc gtgcccgagc cagttccggg      780

cggcaaacat gcacgcgcag atcaagacga gcctgcaccg cctgaagccc gacacggtgc      840

cagcgccctg ctgcgtgccc gccagctaca atcccatggt gctcattcaa aagaccgaca      900

ccggggtgtc gctccagacc tatgatgact tgttagccaa agactgccac tgcatatgag      960

cagtcctggt ccttccactg tgcacctgcg cggaggacgc gacctcagtt gtcctgccct     1020

gtggaatggg ctcaaggttc ctgagacacc cgattcctgc ccaaacagct gtatttatat     1080

aagtctgtta tttattatta atttattggg gtgaccttct tggggactcg ggggctggtc     1140

tgatggaact gtgtatttat ttaaaactct ggtgataaaa ataaagctgt ctgaactgtt     1200

aaaaaaaaaa aaaaaaaaaa                                                 1220


<210>  3
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  4
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  4
gcgcgtaacg gggatcactg tccgctcggg cccgggcgtt gctgccgtct gcacacggtc       60

cgcgcgtcgc tggaagacct gggctgggcc gattgggtgc tgtcgccacg ggaggtgcaa      120

gtgaccatgt gcatcggcgc gtgcccgagc cagttccggg cggcaaacat gcacgcgcag      180

atcaagacga gcctgcaccg cctgaagccc gacacggtgc cagcgccctg ctgcgtgccc      240

gccagctaca atcccatggt gctcattcaa aagaccgaca ccggggtgtc gctccagacc      300

tatgatgact tgttagccaa agactgccac tgcatataa                             339


<210>  5
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  The amino terminus (N-terminus) can either be pegylated 
       (covalently attached to one or more molecules of polyethylene 
       glycol (PEG), or derivatives thereof) or not pegylated.

<400>  5

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
            100                 105                 110         


<210>  6
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  6

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
            100                 105                 110         


<210>  7
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  7

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
            100                 105                 110         


<210>  8
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  8

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  9
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence


<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  The lysine at this position can either be pegylated (covalently 
       attached to one or more molecules of polyethylene glycol (PEG), 
       or derivatives thereof) or not pegylated.

<400>  9

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
            100                 105                 110         


<210>  10
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence


<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  The lysine at this position can either be pegylated (covalently 
       attached to one or more molecules of polyethylene glycol (PEG), 
       or derivatives thereof) or not pegylated.

<400>  10

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
            100                 105                 110         


<210>  11
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  11

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  12
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  12

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
            100                 105                 110         


<210>  13
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  13

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
            100                 105                 110         


<210>  14
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  14

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys Ile 
            100                 105                 110         


<210>  15
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  15

Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys Arg 
1               5                   10                  15      


Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp Trp 
            20                  25                  30          


Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala Cys 
        35                  40                  45              


Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr Ser 
    50                  55                  60                  


Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly Val 
                85                  90                  95      


Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys Ile 
            100                 105                 110         


<210>  16
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  16

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  17
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  17

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  18
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  18

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  19
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  19

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  20
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic protein sequence

<400>  20

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  21
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  21

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  22
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  22

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  23
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  23

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  24

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  25
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  25

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  26
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  26

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Arg Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  27

Pro Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys Cys 
1               5                   10                  15      


Arg Leu Gln Ser Leu Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala Asp 
            20                  25                  30          


Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly Ala 
        35                  40                  45              


Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Gln Thr 
    50                  55                  60                  


Ser Leu His Arg Leu Gln Pro Asp Thr Val Pro Ala Pro Cys Cys Val 
65                  70                  75                  80  


Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Arg Thr Asp Thr Gly 
                85                  90                  95      


Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His Cys 
            100                 105                 110         


Ile 
    


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  28

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  29

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  30
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  30

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  31
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  31

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  32

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  33

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  34

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  35

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  36

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  37

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  38
tgctctagaa tgcccgggca ag                                                22


<210>  39
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  39
ccatcgatct atcatatgca gtggca                                            26


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  40

Gly Ser Gly Gly Ser 
1               5   


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  41

Gly Gly Gly Ser 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  42

Gly Gly Ser Gly 
1               


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  43

Gly Gly Ser Gly Gly 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  44

Gly Ser Gly Ser Gly 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  45

Gly Ser Gly Gly Gly 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  46

Gly Gly Gly Ser Gly 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein sequence

<400>  47

Gly Ser Ser Ser Gly 
1               5   


