                         SEQUENCE LISTING

<110>  CENTRO DE ESTUDIOS CIENTIFICOS DE VALDIVIA
       CARNEGIE INSTITUTION OF WASHINGTON
       Barros, Luis Felipe
       Frommer, Wolf B.
       Ceballo, Sebastian
       San Martin, Alejandro
 
<120>  Genetically encoded probe for quantification of lactate with high
        spatial and temporal resolution, and methods for quantifying 
       metabolic rates and lactate transport using the same

<130>  PAT2392-2011

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  772
<212>  PRT
<213>  Synthetic

<400>  1

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Thr Ser Leu Tyr Lys Lys Ala Gly Ser Glu Phe Ala Leu Gly Thr Met 
                245                 250                 255     


Ile Val Leu Pro Arg Arg Leu Ser Asp Glu Val Ala Asp Arg Val Arg 
            260                 265                 270         


Ala Leu Ile Asp Glu Lys Asn Leu Glu Ala Gly Met Lys Leu Pro Ala 
        275                 280                 285             


Glu Arg Gln Leu Ala Met Gln Leu Gly Val Ser Arg Asn Ser Leu Arg 
    290                 295                 300                 


Glu Ala Leu Ala Lys Leu Val Ser Glu Gly Val Leu Leu Ser Arg Arg 
305                 310                 315                 320 


Gly Gly Gly Thr Phe Ile Arg Trp Arg His Asp Thr Trp Ser Glu Gln 
                325                 330                 335     


Asn Ile Val Gln Pro Leu Lys Thr Leu Met Ala Asp Asp Pro Asp Tyr 
            340                 345                 350         


Ser Phe Asp Ile Leu Glu Ala Arg Tyr Ala Ile Glu Ala Ser Thr Ala 
        355                 360                 365             


Trp His Ala Ala Met Arg Ala Thr Pro Gly Asp Lys Glu Lys Ile Gln 
    370                 375                 380                 


Leu Cys Phe Glu Ala Thr Leu Ser Glu Asp Pro Asp Ile Ala Ser Gln 
385                 390                 395                 400 


Ala Asp Val Arg Phe His Leu Ala Ile Ala Glu Ala Ser His Asn Ile 
                405                 410                 415     


Val Leu Leu Gln Thr Met Arg Gly Phe Phe Asp Val Leu Gln Ser Ser 
            420                 425                 430         


Val Lys His Ser Arg Gln Arg Met Tyr Leu Val Pro Pro Val Phe Ser 
        435                 440                 445             


Gln Leu Thr Glu Gln His Gln Ala Val Ile Asp Ala Ile Phe Ala Gly 
    450                 455                 460                 


Asp Ala Asp Gly Ala Arg Lys Ala Met Met Ala His Leu Ser Phe Val 
465                 470                 475                 480 


His Thr Thr Met Lys Arg Phe Asp Glu Asp Gln Ala Arg His Ala Arg 
                485                 490                 495     


Ile Thr Arg Leu Pro Gly Glu His Asn Glu His Ser Arg Glu Lys Asn 
            500                 505                 510         


Ala Leu Lys Lys Gly Glu Phe Asp Pro Ala Phe Leu Tyr Lys Val Val 
        515                 520                 525             


Leu Lys Arg Ser Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly 
    530                 535                 540                 


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
545                 550                 555                 560 


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
                565                 570                 575     


Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
            580                 585                 590         


Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr 
        595                 600                 605             


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
    610                 615                 620                 


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
625                 630                 635                 640 


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
                645                 650                 655     


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
            660                 665                 670         


His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala 
        675                 680                 685             


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn 
    690                 695                 700                 


Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
705                 710                 715                 720 


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
                725                 730                 735     


Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
            740                 745                 750         


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
        755                 760                 765             


Glu Leu Tyr Lys 
    770         


<210>  2
<211>  745
<212>  PRT
<213>  Synthetic

<400>  2

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Thr Ser Leu Tyr Lys Lys Ala Gly Ser Glu Phe Ala Leu Gly Thr Met 
                245                 250                 255     


Ser Val Lys Ala His Glu Ser Val Met Asp Trp Val Thr Glu Glu Leu 
            260                 265                 270         


Arg Ser Gly Arg Leu Lys Ile Gly Asp His Leu Pro Ser Glu Arg Ala 
        275                 280                 285             


Leu Ser Glu Thr Leu Gly Val Ser Arg Ser Ser Leu Arg Glu Ala Leu 
    290                 295                 300                 


Arg Val Leu Glu Ala Leu Gly Thr Ile Ser Thr Ala Thr Gly Ser Gly 
305                 310                 315                 320 


Pro Arg Ser Gly Thr Ile Ile Thr Ala Ala Pro Gly Gln Ala Leu Ser 
                325                 330                 335     


Leu Ser Val Thr Leu Gln Leu Val Thr Asn Gln Val Gly His His Asp 
            340                 345                 350         


Ile Tyr Glu Thr Arg Gln Leu Leu Glu Gly Trp Ala Ala Leu His Ser 
        355                 360                 365             


Ser Ala Glu Arg Gly Asp Trp Asp Val Ala Glu Ala Leu Leu Glu Lys 
    370                 375                 380                 


Met Asp Asp Pro Ser Leu Pro Leu Glu Asp Phe Leu Arg Phe Asp Ala 
385                 390                 395                 400 


Glu Phe His Val Val Ile Ser Lys Gly Ala Glu Asn Pro Leu Ile Ser 
                405                 410                 415     


Thr Leu Met Glu Ala Leu Arg Leu Ser Val Ala Asp His Thr Val Ala 
            420                 425                 430         


Arg Ala Arg Ala Leu Pro Asp Trp Arg Ala Thr Ser Ala Arg Leu Gln 
        435                 440                 445             


Lys Glu His Arg Ala Ile Leu Ala Ala Leu Arg Ala Gly Glu Ser Thr 
    450                 455                 460                 


Val Ala Ala Thr Leu Ile Lys Glu His Ile Glu Gly Tyr Tyr Glu Glu 
465                 470                 475                 480 


Thr Ala Ala Ala Glu Ala Leu Lys Lys Gly Glu Phe Asp Pro Ala Phe 
                485                 490                 495     


Leu Tyr Lys Val Val Leu Lys Arg Ser Thr Met Val Ser Lys Gly Glu 
            500                 505                 510         


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
        515                 520                 525             


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
    530                 535                 540                 


Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu 
545                 550                 555                 560 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln 
                565                 570                 575     


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
            580                 585                 590         


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
        595                 600                 605             


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
    610                 615                 620                 


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
625                 630                 635                 640 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                645                 650                 655     


Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe 
            660                 665                 670         


Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His 
        675                 680                 685             


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
    690                 695                 700                 


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
705                 710                 715                 720 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
                725                 730                 735     


Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            740                 745 


<210>  3
<211>  757
<212>  PRT
<213>  Synthetic

<400>  3

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Met Ile Val Leu Pro Arg Arg Leu Ser Asp Glu Val Ala Asp Arg Val 
                245                 250                 255     


Arg Ala Leu Ile Asp Glu Lys Asn Leu Glu Ala Gly Met Lys Leu Pro 
            260                 265                 270         


Ala Glu Arg Gln Leu Ala Met Gln Leu Gly Val Ser Arg Asn Ser Leu 
        275                 280                 285             


Arg Glu Ala Leu Ala Lys Leu Val Ser Glu Gly Val Leu Leu Ser Arg 
    290                 295                 300                 


Arg Gly Gly Gly Thr Phe Ile Arg Trp Arg His Asp Thr Trp Ser Glu 
305                 310                 315                 320 


Gln Asn Ile Val Gln Pro Leu Lys Thr Leu Met Ala Asp Asp Pro Asp 
                325                 330                 335     


Tyr Ser Phe Asp Ile Leu Glu Ala Arg Tyr Ala Ile Glu Ala Ser Thr 
            340                 345                 350         


Ala Trp His Ala Ala Met Arg Ala Thr Pro Gly Asp Lys Glu Lys Ile 
        355                 360                 365             


Gln Leu Cys Phe Glu Ala Thr Leu Ser Glu Asp Pro Asp Ile Ala Ser 
    370                 375                 380                 


Gln Ala Asp Val Arg Phe His Leu Ala Ile Ala Glu Ala Ser His Asn 
385                 390                 395                 400 


Ile Val Leu Leu Gln Thr Met Arg Gly Phe Phe Asp Val Leu Gln Ser 
                405                 410                 415     


Ser Val Lys His Ser Arg Gln Arg Met Tyr Leu Val Pro Pro Val Phe 
            420                 425                 430         


Ser Gln Leu Thr Glu Gln His Gln Ala Val Ile Asp Ala Ile Phe Ala 
        435                 440                 445             


Gly Asp Ala Asp Gly Ala Arg Lys Ala Met Met Ala His Leu Ser Phe 
    450                 455                 460                 


Val His Thr Thr Met Lys Arg Phe Asp Glu Asp Gln Ala Arg His Ala 
465                 470                 475                 480 


Arg Ile Thr Arg Leu Pro Gly Glu His Asn Glu His Ser Arg Glu Lys 
                485                 490                 495     


Asn Ala Leu Lys Lys Gly Glu Phe Asp Pro Ala Phe Leu Tyr Lys Val 
            500                 505                 510         


Val Leu Lys Arg Ser Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
        515                 520                 525             


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
    530                 535                 540                 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
545                 550                 555                 560 


Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
                565                 570                 575     


Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg 
            580                 585                 590         


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
        595                 600                 605             


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
    610                 615                 620                 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
625                 630                 635                 640 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
                645                 650                 655     


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr 
            660                 665                 670         


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
        675                 680                 685             


Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
    690                 695                 700                 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
705                 710                 715                 720 


Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
                725                 730                 735     


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
            740                 745                 750         


Asp Glu Leu Tyr Lys 
        755         


<210>  4
<211>  730
<212>  PRT
<213>  Synthetic

<400>  4

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Met Ser Val Lys Ala His Glu Ser Val Met Asp Trp Val Thr Glu Glu 
                245                 250                 255     


Leu Arg Ser Gly Arg Leu Lys Ile Gly Asp His Leu Pro Ser Glu Arg 
            260                 265                 270         


Ala Leu Ser Glu Thr Leu Gly Val Ser Arg Ser Ser Leu Arg Glu Ala 
        275                 280                 285             


Leu Arg Val Leu Glu Ala Leu Gly Thr Ile Ser Thr Ala Thr Gly Ser 
    290                 295                 300                 


Gly Pro Arg Ser Gly Thr Ile Ile Thr Ala Ala Pro Gly Gln Ala Leu 
305                 310                 315                 320 


Ser Leu Ser Val Thr Leu Gln Leu Val Thr Asn Gln Val Gly His His 
                325                 330                 335     


Asp Ile Tyr Glu Thr Arg Gln Leu Leu Glu Gly Trp Ala Ala Leu His 
            340                 345                 350         


Ser Ser Ala Glu Arg Gly Asp Trp Asp Val Ala Glu Ala Leu Leu Glu 
        355                 360                 365             


Lys Met Asp Asp Pro Ser Leu Pro Leu Glu Asp Phe Leu Arg Phe Asp 
    370                 375                 380                 


Ala Glu Phe His Val Val Ile Ser Lys Gly Ala Glu Asn Pro Leu Ile 
385                 390                 395                 400 


Ser Thr Leu Met Glu Ala Leu Arg Leu Ser Val Ala Asp His Thr Val 
                405                 410                 415     


Ala Arg Ala Arg Ala Leu Pro Asp Trp Arg Ala Thr Ser Ala Arg Leu 
            420                 425                 430         


Gln Lys Glu His Arg Ala Ile Leu Ala Ala Leu Arg Ala Gly Glu Ser 
        435                 440                 445             


Thr Val Ala Ala Thr Leu Ile Lys Glu His Ile Glu Gly Tyr Tyr Glu 
    450                 455                 460                 


Glu Thr Ala Ala Ala Glu Ala Leu Lys Lys Gly Glu Phe Asp Pro Ala 
465                 470                 475                 480 


Phe Leu Tyr Lys Val Val Leu Lys Arg Ser Thr Met Val Ser Lys Gly 
                485                 490                 495     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            500                 505                 510         


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        515                 520                 525             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys 
    530                 535                 540                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu 
545                 550                 555                 560 


Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                565                 570                 575     


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
            580                 585                 590         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        595                 600                 605             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    610                 615                 620                 


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
625                 630                 635                 640 


Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
                645                 650                 655     


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp 
            660                 665                 670         


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        675                 680                 685             


Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
    690                 695                 700                 


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
705                 710                 715                 720 


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                725                 730 


<210>  5
<211>  757
<212>  PRT
<213>  Synthetic

<400>  5

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Thr Ser Leu Tyr Lys Lys Ala Gly Ser Glu Phe Ala Leu Gly Thr Met 
                245                 250                 255     


Ile Val Leu Pro Arg Arg Leu Ser Asp Glu Val Ala Asp Arg Val Arg 
            260                 265                 270         


Ala Leu Ile Asp Glu Lys Asn Leu Glu Ala Gly Met Lys Leu Pro Ala 
        275                 280                 285             


Glu Arg Gln Leu Ala Met Gln Leu Gly Val Ser Arg Asn Ser Leu Arg 
    290                 295                 300                 


Glu Ala Leu Ala Lys Leu Val Ser Glu Gly Val Leu Leu Ser Arg Arg 
305                 310                 315                 320 


Gly Gly Gly Thr Phe Ile Arg Trp Arg His Asp Thr Trp Ser Glu Gln 
                325                 330                 335     


Asn Ile Val Gln Pro Leu Lys Thr Leu Met Ala Asp Asp Pro Asp Tyr 
            340                 345                 350         


Ser Phe Asp Ile Leu Glu Ala Arg Tyr Ala Ile Glu Ala Ser Thr Ala 
        355                 360                 365             


Trp His Ala Ala Met Arg Ala Thr Pro Gly Asp Lys Glu Lys Ile Gln 
    370                 375                 380                 


Leu Cys Phe Glu Ala Thr Leu Ser Glu Asp Pro Asp Ile Ala Ser Gln 
385                 390                 395                 400 


Ala Asp Val Arg Phe His Leu Ala Ile Ala Glu Ala Ser His Asn Ile 
                405                 410                 415     


Val Leu Leu Gln Thr Met Arg Gly Phe Phe Asp Val Leu Gln Ser Ser 
            420                 425                 430         


Val Lys His Ser Arg Gln Arg Met Tyr Leu Val Pro Pro Val Phe Ser 
        435                 440                 445             


Gln Leu Thr Glu Gln His Gln Ala Val Ile Asp Ala Ile Phe Ala Gly 
    450                 455                 460                 


Asp Ala Asp Gly Ala Arg Lys Ala Met Met Ala His Leu Ser Phe Val 
465                 470                 475                 480 


His Thr Thr Met Lys Arg Phe Asp Glu Asp Gln Ala Arg His Ala Arg 
                485                 490                 495     


Ile Thr Arg Leu Pro Gly Glu His Asn Glu His Ser Arg Glu Lys Asn 
            500                 505                 510         


Ala Leu Lys Arg Ser Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
        515                 520                 525             


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
    530                 535                 540                 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
545                 550                 555                 560 


Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
                565                 570                 575     


Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg 
            580                 585                 590         


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
        595                 600                 605             


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
    610                 615                 620                 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
625                 630                 635                 640 


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
                645                 650                 655     


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr 
            660                 665                 670         


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
        675                 680                 685             


Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
    690                 695                 700                 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
705                 710                 715                 720 


Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
                725                 730                 735     


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
            740                 745                 750         


Asp Glu Leu Tyr Lys 
        755         


<210>  6
<211>  730
<212>  PRT
<213>  Synthetic

<400>  6

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Thr Ser Leu Tyr Lys Lys Ala Gly Ser Glu Phe Ala Leu Gly Thr Met 
                245                 250                 255     


Ser Val Lys Ala His Glu Ser Val Met Asp Trp Val Thr Glu Glu Leu 
            260                 265                 270         


Arg Ser Gly Arg Leu Lys Ile Gly Asp His Leu Pro Ser Glu Arg Ala 
        275                 280                 285             


Leu Ser Glu Thr Leu Gly Val Ser Arg Ser Ser Leu Arg Glu Ala Leu 
    290                 295                 300                 


Arg Val Leu Glu Ala Leu Gly Thr Ile Ser Thr Ala Thr Gly Ser Gly 
305                 310                 315                 320 


Pro Arg Ser Gly Thr Ile Ile Thr Ala Ala Pro Gly Gln Ala Leu Ser 
                325                 330                 335     


Leu Ser Val Thr Leu Gln Leu Val Thr Asn Gln Val Gly His His Asp 
            340                 345                 350         


Ile Tyr Glu Thr Arg Gln Leu Leu Glu Gly Trp Ala Ala Leu His Ser 
        355                 360                 365             


Ser Ala Glu Arg Gly Asp Trp Asp Val Ala Glu Ala Leu Leu Glu Lys 
    370                 375                 380                 


Met Asp Asp Pro Ser Leu Pro Leu Glu Asp Phe Leu Arg Phe Asp Ala 
385                 390                 395                 400 


Glu Phe His Val Val Ile Ser Lys Gly Ala Glu Asn Pro Leu Ile Ser 
                405                 410                 415     


Thr Leu Met Glu Ala Leu Arg Leu Ser Val Ala Asp His Thr Val Ala 
            420                 425                 430         


Arg Ala Arg Ala Leu Pro Asp Trp Arg Ala Thr Ser Ala Arg Leu Gln 
        435                 440                 445             


Lys Glu His Arg Ala Ile Leu Ala Ala Leu Arg Ala Gly Glu Ser Thr 
    450                 455                 460                 


Val Ala Ala Thr Leu Ile Lys Glu His Ile Glu Gly Tyr Tyr Glu Glu 
465                 470                 475                 480 


Thr Ala Ala Ala Glu Ala Leu Lys Arg Ser Thr Met Val Ser Lys Gly 
                485                 490                 495     


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
            500                 505                 510         


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
        515                 520                 525             


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys 
    530                 535                 540                 


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu 
545                 550                 555                 560 


Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
                565                 570                 575     


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
            580                 585                 590         


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
        595                 600                 605             


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
    610                 615                 620                 


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
625                 630                 635                 640 


Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn 
                645                 650                 655     


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp 
            660                 665                 670         


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
        675                 680                 685             


Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
    690                 695                 700                 


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
705                 710                 715                 720 


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                725                 730 


<210>  7
<211>  742
<212>  PRT
<213>  Synthetic

<400>  7

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Met Ile Val Leu Pro Arg Arg Leu Ser Asp Glu Val Ala Asp Arg Val 
                245                 250                 255     


Arg Ala Leu Ile Asp Glu Lys Asn Leu Glu Ala Gly Met Lys Leu Pro 
            260                 265                 270         


Ala Glu Arg Gln Leu Ala Met Gln Leu Gly Val Ser Arg Asn Ser Leu 
        275                 280                 285             


Arg Glu Ala Leu Ala Lys Leu Val Ser Glu Gly Val Leu Leu Ser Arg 
    290                 295                 300                 


Arg Gly Gly Gly Thr Phe Ile Arg Trp Arg His Asp Thr Trp Ser Glu 
305                 310                 315                 320 


Gln Asn Ile Val Gln Pro Leu Lys Thr Leu Met Ala Asp Asp Pro Asp 
                325                 330                 335     


Tyr Ser Phe Asp Ile Leu Glu Ala Arg Tyr Ala Ile Glu Ala Ser Thr 
            340                 345                 350         


Ala Trp His Ala Ala Met Arg Ala Thr Pro Gly Asp Lys Glu Lys Ile 
        355                 360                 365             


Gln Leu Cys Phe Glu Ala Thr Leu Ser Glu Asp Pro Asp Ile Ala Ser 
    370                 375                 380                 


Gln Ala Asp Val Arg Phe His Leu Ala Ile Ala Glu Ala Ser His Asn 
385                 390                 395                 400 


Ile Val Leu Leu Gln Thr Met Arg Gly Phe Phe Asp Val Leu Gln Ser 
                405                 410                 415     


Ser Val Lys His Ser Arg Gln Arg Met Tyr Leu Val Pro Pro Val Phe 
            420                 425                 430         


Ser Gln Leu Thr Glu Gln His Gln Ala Val Ile Asp Ala Ile Phe Ala 
        435                 440                 445             


Gly Asp Ala Asp Gly Ala Arg Lys Ala Met Met Ala His Leu Ser Phe 
    450                 455                 460                 


Val His Thr Thr Met Lys Arg Phe Asp Glu Asp Gln Ala Arg His Ala 
465                 470                 475                 480 


Arg Ile Thr Arg Leu Pro Gly Glu His Asn Glu His Ser Arg Glu Lys 
                485                 490                 495     


Asn Ala Leu Lys Arg Ser Thr Met Val Ser Lys Gly Glu Glu Leu Phe 
            500                 505                 510         


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
        515                 520                 525             


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
    530                 535                 540                 


Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
545                 550                 555                 560 


Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala 
                565                 570                 575     


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
            580                 585                 590         


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
        595                 600                 605             


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
    610                 615                 620                 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
625                 630                 635                 640 


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
                645                 650                 655     


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
            660                 665                 670         


His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln 
        675                 680                 685             


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
    690                 695                 700                 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
705                 710                 715                 720 


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
                725                 730                 735     


Met Asp Glu Leu Tyr Lys 
            740         


<210>  8
<211>  715
<212>  PRT
<213>  Synthetic

<400>  8

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Met Ser Val Lys Ala His Glu Ser Val Met Asp Trp Val Thr Glu Glu 
                245                 250                 255     


Leu Arg Ser Gly Arg Leu Lys Ile Gly Asp His Leu Pro Ser Glu Arg 
            260                 265                 270         


Ala Leu Ser Glu Thr Leu Gly Val Ser Arg Ser Ser Leu Arg Glu Ala 
        275                 280                 285             


Leu Arg Val Leu Glu Ala Leu Gly Thr Ile Ser Thr Ala Thr Gly Ser 
    290                 295                 300                 


Gly Pro Arg Ser Gly Thr Ile Ile Thr Ala Ala Pro Gly Gln Ala Leu 
305                 310                 315                 320 


Ser Leu Ser Val Thr Leu Gln Leu Val Thr Asn Gln Val Gly His His 
                325                 330                 335     


Asp Ile Tyr Glu Thr Arg Gln Leu Leu Glu Gly Trp Ala Ala Leu His 
            340                 345                 350         


Ser Ser Ala Glu Arg Gly Asp Trp Asp Val Ala Glu Ala Leu Leu Glu 
        355                 360                 365             


Lys Met Asp Asp Pro Ser Leu Pro Leu Glu Asp Phe Leu Arg Phe Asp 
    370                 375                 380                 


Ala Glu Phe His Val Val Ile Ser Lys Gly Ala Glu Asn Pro Leu Ile 
385                 390                 395                 400 


Ser Thr Leu Met Glu Ala Leu Arg Leu Ser Val Ala Asp His Thr Val 
                405                 410                 415     


Ala Arg Ala Arg Ala Leu Pro Asp Trp Arg Ala Thr Ser Ala Arg Leu 
            420                 425                 430         


Gln Lys Glu His Arg Ala Ile Leu Ala Ala Leu Arg Ala Gly Glu Ser 
        435                 440                 445             


Thr Val Ala Ala Thr Leu Ile Lys Glu His Ile Glu Gly Tyr Tyr Glu 
    450                 455                 460                 


Glu Thr Ala Ala Ala Glu Ala Leu Lys Arg Ser Thr Met Val Ser Lys 
465                 470                 475                 480 


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
                485                 490                 495     


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
            500                 505                 510         


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly 
        515                 520                 525             


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly 
    530                 535                 540                 


Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
545                 550                 555                 560 


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
                565                 570                 575     


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
            580                 585                 590         


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
        595                 600                 605             


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
    610                 615                 620                 


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
625                 630                 635                 640 


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala 
                645                 650                 655     


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
            660                 665                 670         


Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro 
        675                 680                 685             


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
    690                 695                 700                 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
705                 710                 715 


<210>  9
<211>  693
<212>  PRT
<213>  Synthetic

<400>  9

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Thr Ser Leu Tyr Lys Lys Ala Gly Ser Glu Phe Ala Leu Gly Thr Glu 
                245                 250                 255     


Gln Asn Ile Val Gln Pro Leu Lys Thr Leu Met Ala Asp Asp Pro Asp 
            260                 265                 270         


Tyr Ser Phe Asp Ile Leu Glu Ala Arg Tyr Ala Ile Glu Ala Ser Thr 
        275                 280                 285             


Ala Trp His Ala Ala Met Arg Ala Thr Pro Gly Asp Lys Glu Lys Ile 
    290                 295                 300                 


Gln Leu Cys Phe Glu Ala Thr Leu Ser Glu Asp Pro Asp Ile Ala Ser 
305                 310                 315                 320 


Gln Ala Asp Val Arg Phe His Leu Ala Ile Ala Glu Ala Ser His Asn 
                325                 330                 335     


Ile Val Leu Leu Gln Thr Met Arg Gly Phe Phe Asp Val Leu Gln Ser 
            340                 345                 350         


Ser Val Lys His Ser Arg Gln Arg Met Tyr Leu Val Pro Pro Val Phe 
        355                 360                 365             


Ser Gln Leu Thr Glu Gln His Gln Ala Val Ile Asp Ala Ile Phe Ala 
    370                 375                 380                 


Gly Asp Ala Asp Gly Ala Arg Lys Ala Met Met Ala His Leu Ser Phe 
385                 390                 395                 400 


Val His Thr Thr Met Lys Arg Phe Asp Glu Asp Gln Ala Arg His Ala 
                405                 410                 415     


Arg Ile Thr Arg Leu Pro Gly Glu His Asn Glu His Ser Arg Glu Lys 
            420                 425                 430         


Asn Ala Leu Lys Lys Gly Glu Phe Asp Pro Ala Phe Leu Tyr Lys Val 
        435                 440                 445             


Val Leu Lys Arg Ser Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr 
    450                 455                 460                 


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
465                 470                 475                 480 


Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys 
                485                 490                 495     


Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
            500                 505                 510         


Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg 
        515                 520                 525             


Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
    530                 535                 540                 


Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn 
545                 550                 555                 560 


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
                565                 570                 575     


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
            580                 585                 590         


Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr 
        595                 600                 605             


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
    610                 615                 620                 


Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
625                 630                 635                 640 


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
                645                 650                 655     


Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
            660                 665                 670         


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met 
        675                 680                 685             


Asp Glu Leu Tyr Lys 
    690             


<210>  10
<211>  669
<212>  PRT
<213>  Synthetic

<400>  10

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Thr Ser Leu Tyr Lys Lys Ala Gly Ser Glu Phe Ala Leu Gly Thr Gly 
                245                 250                 255     


Gln Ala Leu Ser Leu Ser Val Thr Leu Gln Leu Val Thr Asn Gln Val 
            260                 265                 270         


Gly His His Asp Ile Tyr Glu Thr Arg Gln Leu Leu Glu Gly Trp Ala 
        275                 280                 285             


Ala Leu His Ser Ser Ala Glu Arg Gly Asp Trp Asp Val Ala Glu Ala 
    290                 295                 300                 


Leu Leu Glu Lys Met Asp Asp Pro Ser Leu Pro Leu Glu Asp Phe Leu 
305                 310                 315                 320 


Arg Phe Asp Ala Glu Phe His Val Val Ile Ser Lys Gly Ala Glu Asn 
                325                 330                 335     


Pro Leu Ile Ser Thr Leu Met Glu Ala Leu Arg Leu Ser Val Ala Asp 
            340                 345                 350         


His Thr Val Ala Arg Ala Arg Ala Leu Pro Asp Trp Arg Ala Thr Ser 
        355                 360                 365             


Ala Arg Leu Gln Lys Glu His Arg Ala Ile Leu Ala Ala Leu Arg Ala 
    370                 375                 380                 


Gly Glu Ser Thr Val Ala Ala Thr Leu Ile Lys Glu His Ile Glu Gly 
385                 390                 395                 400 


Tyr Tyr Glu Glu Thr Ala Ala Ala Glu Ala Leu Lys Lys Gly Glu Phe 
                405                 410                 415     


Asp Pro Ala Phe Leu Tyr Lys Val Val Leu Lys Arg Ser Thr Met Val 
            420                 425                 430         


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
        435                 440                 445             


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
    450                 455                 460                 


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys Thr 
465                 470                 475                 480 


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Gly 
                485                 490                 495     


Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His 
            500                 505                 510         


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
        515                 520                 525             


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
    530                 535                 540                 


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
545                 550                 555                 560 


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
                565                 570                 575     


Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
            580                 585                 590         


Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln 
        595                 600                 605             


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
    610                 615                 620                 


Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys 
625                 630                 635                 640 


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
                645                 650                 655     


Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            660                 665                 


<210>  11
<211>  678
<212>  PRT
<213>  Synthetic

<400>  11

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Glu Gln Asn Ile Val Gln Pro Leu Lys Thr Leu Met Ala Asp Asp Pro 
                245                 250                 255     


Asp Tyr Ser Phe Asp Ile Leu Glu Ala Arg Tyr Ala Ile Glu Ala Ser 
            260                 265                 270         


Thr Ala Trp His Ala Ala Met Arg Ala Thr Pro Gly Asp Lys Glu Lys 
        275                 280                 285             


Ile Gln Leu Cys Phe Glu Ala Thr Leu Ser Glu Asp Pro Asp Ile Ala 
    290                 295                 300                 


Ser Gln Ala Asp Val Arg Phe His Leu Ala Ile Ala Glu Ala Ser His 
305                 310                 315                 320 


Asn Ile Val Leu Leu Gln Thr Met Arg Gly Phe Phe Asp Val Leu Gln 
                325                 330                 335     


Ser Ser Val Lys His Ser Arg Gln Arg Met Tyr Leu Val Pro Pro Val 
            340                 345                 350         


Phe Ser Gln Leu Thr Glu Gln His Gln Ala Val Ile Asp Ala Ile Phe 
        355                 360                 365             


Ala Gly Asp Ala Asp Gly Ala Arg Lys Ala Met Met Ala His Leu Ser 
    370                 375                 380                 


Phe Val His Thr Thr Met Lys Arg Phe Asp Glu Asp Gln Ala Arg His 
385                 390                 395                 400 


Ala Arg Ile Thr Arg Leu Pro Gly Glu His Asn Glu His Ser Arg Glu 
                405                 410                 415     


Lys Asn Ala Leu Lys Lys Gly Glu Phe Asp Pro Ala Phe Leu Tyr Lys 
            420                 425                 430         


Val Val Leu Lys Arg Ser Thr Met Val Ser Lys Gly Glu Glu Leu Phe 
        435                 440                 445             


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
    450                 455                 460                 


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
465                 470                 475                 480 


Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
                485                 490                 495     


Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala 
            500                 505                 510         


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
        515                 520                 525             


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
    530                 535                 540                 


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
545                 550                 555                 560 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
                565                 570                 575     


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
            580                 585                 590         


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
        595                 600                 605             


His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln 
    610                 615                 620                 


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
625                 630                 635                 640 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
                645                 650                 655     


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
            660                 665                 670         


Met Asp Glu Leu Tyr Lys 
        675             


<210>  12
<211>  654
<212>  PRT
<213>  Synthetic

<400>  12

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Gly Gln Ala Leu Ser Leu Ser Val Thr Leu Gln Leu Val Thr Asn Gln 
                245                 250                 255     


Val Gly His His Asp Ile Tyr Glu Thr Arg Gln Leu Leu Glu Gly Trp 
            260                 265                 270         


Ala Ala Leu His Ser Ser Ala Glu Arg Gly Asp Trp Asp Val Ala Glu 
        275                 280                 285             


Ala Leu Leu Glu Lys Met Asp Asp Pro Ser Leu Pro Leu Glu Asp Phe 
    290                 295                 300                 


Leu Arg Phe Asp Ala Glu Phe His Val Val Ile Ser Lys Gly Ala Glu 
305                 310                 315                 320 


Asn Pro Leu Ile Ser Thr Leu Met Glu Ala Leu Arg Leu Ser Val Ala 
                325                 330                 335     


Asp His Thr Val Ala Arg Ala Arg Ala Leu Pro Asp Trp Arg Ala Thr 
            340                 345                 350         


Ser Ala Arg Leu Gln Lys Glu His Arg Ala Ile Leu Ala Ala Leu Arg 
        355                 360                 365             


Ala Gly Glu Ser Thr Val Ala Ala Thr Leu Ile Lys Glu His Ile Glu 
    370                 375                 380                 


Gly Tyr Tyr Glu Glu Thr Ala Ala Ala Glu Ala Leu Lys Lys Gly Glu 
385                 390                 395                 400 


Phe Asp Pro Ala Phe Leu Tyr Lys Val Val Leu Lys Arg Ser Thr Met 
                405                 410                 415     


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
            420                 425                 430         


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
        435                 440                 445             


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys 
    450                 455                 460                 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
465                 470                 475                 480 


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
                485                 490                 495     


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
            500                 505                 510         


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
        515                 520                 525             


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
    530                 535                 540                 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
545                 550                 555                 560 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
                565                 570                 575     


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val 
            580                 585                 590         


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
        595                 600                 605             


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
    610                 615                 620                 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
625                 630                 635                 640 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                645                 650                 


<210>  13
<211>  678
<212>  PRT
<213>  Synthetic

<400>  13

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Thr Ser Leu Tyr Lys Lys Ala Gly Ser Glu Phe Ala Leu Gly Thr Glu 
                245                 250                 255     


Gln Asn Ile Val Gln Pro Leu Lys Thr Leu Met Ala Asp Asp Pro Asp 
            260                 265                 270         


Tyr Ser Phe Asp Ile Leu Glu Ala Arg Tyr Ala Ile Glu Ala Ser Thr 
        275                 280                 285             


Ala Trp His Ala Ala Met Arg Ala Thr Pro Gly Asp Lys Glu Lys Ile 
    290                 295                 300                 


Gln Leu Cys Phe Glu Ala Thr Leu Ser Glu Asp Pro Asp Ile Ala Ser 
305                 310                 315                 320 


Gln Ala Asp Val Arg Phe His Leu Ala Ile Ala Glu Ala Ser His Asn 
                325                 330                 335     


Ile Val Leu Leu Gln Thr Met Arg Gly Phe Phe Asp Val Leu Gln Ser 
            340                 345                 350         


Ser Val Lys His Ser Arg Gln Arg Met Tyr Leu Val Pro Pro Val Phe 
        355                 360                 365             


Ser Gln Leu Thr Glu Gln His Gln Ala Val Ile Asp Ala Ile Phe Ala 
    370                 375                 380                 


Gly Asp Ala Asp Gly Ala Arg Lys Ala Met Met Ala His Leu Ser Phe 
385                 390                 395                 400 


Val His Thr Thr Met Lys Arg Phe Asp Glu Asp Gln Ala Arg His Ala 
                405                 410                 415     


Arg Ile Thr Arg Leu Pro Gly Glu His Asn Glu His Ser Arg Glu Lys 
            420                 425                 430         


Asn Ala Leu Lys Arg Ser Thr Met Val Ser Lys Gly Glu Glu Leu Phe 
        435                 440                 445             


Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly 
    450                 455                 460                 


His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly 
465                 470                 475                 480 


Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro 
                485                 490                 495     


Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala 
            500                 505                 510         


Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met 
        515                 520                 525             


Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
    530                 535                 540                 


Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val 
545                 550                 555                 560 


Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile 
                565                 570                 575     


Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile 
            580                 585                 590         


Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg 
        595                 600                 605             


His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln 
    610                 615                 620                 


Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr 
625                 630                 635                 640 


Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp 
                645                 650                 655     


His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly 
            660                 665                 670         


Met Asp Glu Leu Tyr Lys 
        675             


<210>  14
<211>  654
<212>  PRT
<213>  Synthetic

<400>  14

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Thr Ser Leu Tyr Lys Lys Ala Gly Ser Glu Phe Ala Leu Gly Thr Gly 
                245                 250                 255     


Gln Ala Leu Ser Leu Ser Val Thr Leu Gln Leu Val Thr Asn Gln Val 
            260                 265                 270         


Gly His His Asp Ile Tyr Glu Thr Arg Gln Leu Leu Glu Gly Trp Ala 
        275                 280                 285             


Ala Leu His Ser Ser Ala Glu Arg Gly Asp Trp Asp Val Ala Glu Ala 
    290                 295                 300                 


Leu Leu Glu Lys Met Asp Asp Pro Ser Leu Pro Leu Glu Asp Phe Leu 
305                 310                 315                 320 


Arg Phe Asp Ala Glu Phe His Val Val Ile Ser Lys Gly Ala Glu Asn 
                325                 330                 335     


Pro Leu Ile Ser Thr Leu Met Glu Ala Leu Arg Leu Ser Val Ala Asp 
            340                 345                 350         


His Thr Val Ala Arg Ala Arg Ala Leu Pro Asp Trp Arg Ala Thr Ser 
        355                 360                 365             


Ala Arg Leu Gln Lys Glu His Arg Ala Ile Leu Ala Ala Leu Arg Ala 
    370                 375                 380                 


Gly Glu Ser Thr Val Ala Ala Thr Leu Ile Lys Glu His Ile Glu Gly 
385                 390                 395                 400 


Tyr Tyr Glu Glu Thr Ala Ala Ala Glu Ala Leu Lys Arg Ser Thr Met 
                405                 410                 415     


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
            420                 425                 430         


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
        435                 440                 445             


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile Cys 
    450                 455                 460                 


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
465                 470                 475                 480 


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
                485                 490                 495     


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
            500                 505                 510         


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
        515                 520                 525             


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
    530                 535                 540                 


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
545                 550                 555                 560 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
                565                 570                 575     


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val 
            580                 585                 590         


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
        595                 600                 605             


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
    610                 615                 620                 


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
625                 630                 635                 640 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                645                 650                 


<210>  15
<211>  663
<212>  PRT
<213>  Synthetic

<400>  15

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Glu Gln Asn Ile Val Gln Pro Leu Lys Thr Leu Met Ala Asp Asp Pro 
                245                 250                 255     


Asp Tyr Ser Phe Asp Ile Leu Glu Ala Arg Tyr Ala Ile Glu Ala Ser 
            260                 265                 270         


Thr Ala Trp His Ala Ala Met Arg Ala Thr Pro Gly Asp Lys Glu Lys 
        275                 280                 285             


Ile Gln Leu Cys Phe Glu Ala Thr Leu Ser Glu Asp Pro Asp Ile Ala 
    290                 295                 300                 


Ser Gln Ala Asp Val Arg Phe His Leu Ala Ile Ala Glu Ala Ser His 
305                 310                 315                 320 


Asn Ile Val Leu Leu Gln Thr Met Arg Gly Phe Phe Asp Val Leu Gln 
                325                 330                 335     


Ser Ser Val Lys His Ser Arg Gln Arg Met Tyr Leu Val Pro Pro Val 
            340                 345                 350         


Phe Ser Gln Leu Thr Glu Gln His Gln Ala Val Ile Asp Ala Ile Phe 
        355                 360                 365             


Ala Gly Asp Ala Asp Gly Ala Arg Lys Ala Met Met Ala His Leu Ser 
    370                 375                 380                 


Phe Val His Thr Thr Met Lys Arg Phe Asp Glu Asp Gln Ala Arg His 
385                 390                 395                 400 


Ala Arg Ile Thr Arg Leu Pro Gly Glu His Asn Glu His Ser Arg Glu 
                405                 410                 415     


Lys Asn Ala Leu Lys Arg Ser Thr Met Val Ser Lys Gly Glu Glu Leu 
            420                 425                 430         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        435                 440                 445             


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    450                 455                 460                 


Gly Lys Leu Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val 
465                 470                 475                 480 


Pro Trp Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe 
                485                 490                 495     


Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            500                 505                 510         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        515                 520                 525             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    530                 535                 540                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
545                 550                 555                 560 


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
                565                 570                 575     


Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile 
            580                 585                 590         


Arg His Asn Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln 
        595                 600                 605             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    610                 615                 620                 


Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
625                 630                 635                 640 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
                645                 650                 655     


Gly Met Asp Glu Leu Tyr Lys 
            660             


<210>  16
<211>  639
<212>  PRT
<213>  Synthetic

<400>  16

Met Val Ser Lys Gly Glu Glu Thr Thr Met Gly Val Ile Lys Pro Asp 
1               5                   10                  15      


Met Lys Ile Lys Leu Lys Met Glu Gly Asn Val Asn Gly His Ala Phe 
            20                  25                  30          


Val Ile Glu Gly Glu Gly Glu Gly Lys Pro Tyr Asp Gly Thr Asn Thr 
        35                  40                  45              


Ile Asn Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ser Tyr Asp 
    50                  55                  60                  


Ile Leu Thr Thr Ala Phe Ala Tyr Gly Asn Arg Ala Phe Thr Lys Tyr 
65                  70                  75                  80  


Pro Asp Asp Ile Pro Asn Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr 
                85                  90                  95      


Ser Trp Glu Arg Thr Met Thr Phe Glu Asp Lys Gly Ile Val Lys Val 
            100                 105                 110         


Lys Ser Asp Ile Ser Met Glu Glu Asp Ser Phe Ile Tyr Glu Ile His 
        115                 120                 125             


Leu Lys Gly Glu Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Thr Gly Trp Asp Ala Ser Thr Glu Arg Met Tyr Val Arg Asp Gly 
145                 150                 155                 160 


Val Leu Lys Gly Asp Val Lys His Lys Leu Leu Leu Glu Gly Gly Gly 
                165                 170                 175     


His His Arg Val Asp Phe Lys Thr Ile Tyr Arg Ala Lys Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Asn 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Thr Val Tyr Glu Ser Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Gly Met Asp Glu Leu Tyr Lys Arg Ser Gly Thr 
225                 230                 235                 240 


Gly Gln Ala Leu Ser Leu Ser Val Thr Leu Gln Leu Val Thr Asn Gln 
                245                 250                 255     


Val Gly His His Asp Ile Tyr Glu Thr Arg Gln Leu Leu Glu Gly Trp 
            260                 265                 270         


Ala Ala Leu His Ser Ser Ala Glu Arg Gly Asp Trp Asp Val Ala Glu 
        275                 280                 285             


Ala Leu Leu Glu Lys Met Asp Asp Pro Ser Leu Pro Leu Glu Asp Phe 
    290                 295                 300                 


Leu Arg Phe Asp Ala Glu Phe His Val Val Ile Ser Lys Gly Ala Glu 
305                 310                 315                 320 


Asn Pro Leu Ile Ser Thr Leu Met Glu Ala Leu Arg Leu Ser Val Ala 
                325                 330                 335     


Asp His Thr Val Ala Arg Ala Arg Ala Leu Pro Asp Trp Arg Ala Thr 
            340                 345                 350         


Ser Ala Arg Leu Gln Lys Glu His Arg Ala Ile Leu Ala Ala Leu Arg 
        355                 360                 365             


Ala Gly Glu Ser Thr Val Ala Ala Thr Leu Ile Lys Glu His Ile Glu 
    370                 375                 380                 


Gly Tyr Tyr Glu Glu Thr Ala Ala Ala Glu Ala Leu Lys Arg Ser Thr 
385                 390                 395                 400 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
                405                 410                 415     


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            420                 425                 430         


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Leu Ile 
        435                 440                 445             


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    450                 455                 460                 


Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
465                 470                 475                 480 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                485                 490                 495     


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            500                 505                 510         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        515                 520                 525             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    530                 535                 540                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
545                 550                 555                 560 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                565                 570                 575     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            580                 585                 590         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu 
        595                 600                 605             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    610                 615                 620                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
625                 630                 635                 


<210>  17
<211>  2319
<212>  DNA
<213>  Synthetic

<400>  17
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

acaagtttgt acaaaaaagc aggctccgaa ttcgcccttg gtaccatgat tgttttaccc      780

agacgcctgt cagacgaggt tgccgatcgt gtgcgggcgc tgattgatga aaaaaacctg      840

gaagcgggca tgaagttgcc cgctgagcgc caactggcga tgcaactcgg cgtatcacgt      900

aattcactgc gcgaggcgct ggcaaaactg gtgagtgaag gcgtgctgct cagtcgacgc      960

ggcggcggga cgtttattcg ctggcgtcat gacacatggt cggagcaaaa catcgtccag     1020

ccgctaaaaa cactgatggc cgatgatccg gattacagtt tcgatattct ggaagcccgc     1080

tacgccattg aagccagcac cgcatggcat gcggcaatgc gcgccacacc tggcgacaaa     1140

gaaaagattc agctttgctt tgaagcaacg ctaagtgaag acccggatat cgcctcacaa     1200

gcggacgttc gttttcatct ggcgattgcc gaagcctcac ataacatcgt gctgctgcaa     1260

accatgcgcg gtttcttcga tgtcctgcaa tcctcagtga agcatagccg tcagcggatg     1320

tatctggtgc caccggtttt ttcacaactg accgaacaac atcaggctgt cattgacgcc     1380

atttttgccg gtgatgctga cggggcgcgt aaagcaatga tggcgcacct tagttttgtt     1440

cacaccacca tgaaacgatt cgatgaagat caggctcgcc acgcacggat tacccgcctg     1500

cccggtgagc ataatgagca ttcgagggag aaaaacgcac ttaagaaggg cgaattcgac     1560

ccagctttct tgtacaaagt ggtgcttaag agatctacca tggtgagcaa gggcgaggag     1620

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag     1680

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagctg     1740

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgggctac     1800

ggcctgcagt gcttcgcccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc     1860

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac     1920

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag     1980

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac     2040

agccacaacg tctatatcac cgccgacaag cagaagaacg gcatcaaggc caacttcaag     2100

atccgccaca acatcgagga cggcggcgtg cagctcgccg accactacca gcagaacacc     2160

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcta ccagtccgcc     2220

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc     2280

gccgggatca ctctcggcat ggacgagctg tacaagtaa                            2319


<210>  18
<211>  2238
<212>  DNA
<213>  Synthetic

<400>  18
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

acaagtttgt acaaaaaagc aggctccgaa ttcgcccttg gtaccatgag tgtgaaagca      780

catgaatctg tcatggattg ggtcaccgag gagctccgca gcggtcgcct aaaaatcggt      840

gaccacctcc ccagcgaacg ggcgctctcc gaaaccctcg gagtttcccg aagctccctg      900

cgcgaggcgc ttcgtgtgct cgaagccctc ggcaccattt ccaccgccac cggctccggc      960

ccgcggtctg gcaccatcat cactgctgcc cctggccagg cgctttccct ctccgtgacg     1020

ctgcagttgg tcaccaacca ggtcggccac cacgatattt atgaaacccg ccaactcctt     1080

gaaggctggg ctgccctgca ttccagcgcc gaacgtggcg actgggacgt ggcagaagcg     1140

ttgctggaaa agatggacga cccctcgcta ccgctcgagg attttttgcg tttcgacgcc     1200

gaattccacg ttgttatctc caaaggcgcg gaaaaccctc tgatcagtac gctcatggaa     1260

gccctccgtt tgtccgtggc agatcacacc gttgccaggg cccgggcgct ccccgattgg     1320

cgagccacct cggcgcgtct gcagaaagaa caccgcgcaa tcctcgcagc acttcgcgca     1380

ggcgaatcca cagtggccgc aaccttgatc aaagaacaca tcgaaggcta ctacgaagaa     1440

accgctgccg ccgaggccct taagaagggc gaattcgacc cagctttctt gtacaaagtg     1500

gtgcttaaga gatctaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc     1560

atcctggtcg agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc     1620

gagggcgatg ccacctacgg caagctgacc ctgaagctga tctgcaccac cggcaagctg     1680

cccgtgccct ggcccaccct cgtgaccacc ctgggctacg gcctgcagtg cttcgcccgc     1740

taccccgacc acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc     1800

caggagcgca ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag     1860

ttcgagggcg acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac     1920

ggcaacatcc tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcacc     1980

gccgacaagc agaagaacgg catcaaggcc aacttcaaga tccgccacaa catcgaggac     2040

ggcggcgtgc agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg     2100

ctgctgcccg acaaccacta cctgagctac cagtccgccc tgagcaaaga ccccaacgag     2160

aagcgcgatc acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg     2220

gacgagctgt acaagtaa                                                   2238


<210>  19
<211>  2274
<212>  DNA
<213>  Synthetic

<400>  19
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

atgattgttt tacccagacg cctgtcagac gaggttgccg atcgtgtgcg ggcgctgatt      780

gatgaaaaaa acctggaagc gggcatgaag ttgcccgctg agcgccaact ggcgatgcaa      840

ctcggcgtat cacgtaattc actgcgcgag gcgctggcaa aactggtgag tgaaggcgtg      900

ctgctcagtc gacgcggcgg cgggacgttt attcgctggc gtcatgacac atggtcggag      960

caaaacatcg tccagccgct aaaaacactg atggccgatg atccggatta cagtttcgat     1020

attctggaag cccgctacgc cattgaagcc agcaccgcat ggcatgcggc aatgcgcgcc     1080

acacctggcg acaaagaaaa gattcagctt tgctttgaag caacgctaag tgaagacccg     1140

gatatcgcct cacaagcgga cgttcgtttt catctggcga ttgccgaagc ctcacataac     1200

atcgtgctgc tgcaaaccat gcgcggtttc ttcgatgtcc tgcaatcctc agtgaagcat     1260

agccgtcagc ggatgtatct ggtgccaccg gttttttcac aactgaccga acaacatcag     1320

gctgtcattg acgccatttt tgccggtgat gctgacgggg cgcgtaaagc aatgatggcg     1380

caccttagtt ttgttcacac caccatgaaa cgattcgatg aagatcaggc tcgccacgca     1440

cggattaccc gcctgcccgg tgagcataat gagcattcga gggagaaaaa cgcacttaag     1500

aagggcgaat tcgacccagc tttcttgtac aaagtggtgc ttaagagatc taccatggtg     1560

agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac     1620

gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag     1680

ctgaccctga agctgatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg     1740

accaccctgg gctacggcct gcagtgcttc gcccgctacc ccgaccacat gaagcagcac     1800

gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag     1860

gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac     1920

cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg     1980

gagtacaact acaacagcca caacgtctat atcaccgccg acaagcagaa gaacggcatc     2040

aaggccaact tcaagatccg ccacaacatc gaggacggcg gcgtgcagct cgccgaccac     2100

taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg     2160

agctaccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg     2220

gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaa           2274


<210>  20
<211>  2193
<212>  DNA
<213>  Synthetic

<400>  20
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

atgagtgtga aagcacatga atctgtcatg gattgggtca ccgaggagct ccgcagcggt      780

cgcctaaaaa tcggtgacca cctccccagc gaacgggcgc tctccgaaac cctcggagtt      840

tcccgaagct ccctgcgcga ggcgcttcgt gtgctcgaag ccctcggcac catttccacc      900

gccaccggct ccggcccgcg gtctggcacc atcatcactg ctgcccctgg ccaggcgctt      960

tccctctccg tgacgctgca gttggtcacc aaccaggtcg gccaccacga tatttatgaa     1020

acccgccaac tccttgaagg ctgggctgcc ctgcattcca gcgccgaacg tggcgactgg     1080

gacgtggcag aagcgttgct ggaaaagatg gacgacccct cgctaccgct cgaggatttt     1140

ttgcgtttcg acgccgaatt ccacgttgtt atctccaaag gcgcggaaaa ccctctgatc     1200

agtacgctca tggaagccct ccgtttgtcc gtggcagatc acaccgttgc cagggcccgg     1260

gcgctccccg attggcgagc cacctcggcg cgtctgcaga aagaacaccg cgcaatcctc     1320

gcagcacttc gcgcaggcga atccacagtg gccgcaacct tgatcaaaga acacatcgaa     1380

ggctactacg aagaaaccgc tgccgccgag gcccttaaga agggcgaatt cgacccagct     1440

ttcttgtaca aagtggtgct taagagatct accatggtga gcaagggcga ggagctgttc     1500

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc     1560

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gctgatctgc     1620

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctggg ctacggcctg     1680

cagtgcttcg cccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg     1740

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc     1800

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc     1860

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac     1920

aacgtctata tcaccgccga caagcagaag aacggcatca aggccaactt caagatccgc     1980

cacaacatcg aggacggcgg cgtgcagctc gccgaccact accagcagaa cacccccatc     2040

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gctaccagtc cgccctgagc     2100

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg     2160

atcactctcg gcatggacga gctgtacaag taa                                  2193


<210>  21
<211>  2274
<212>  DNA
<213>  Synthetic

<400>  21
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

acaagtttgt acaaaaaagc aggctccgaa ttcgcccttg gtaccatgat tgttttaccc      780

agacgcctgt cagacgaggt tgccgatcgt gtgcgggcgc tgattgatga aaaaaacctg      840

gaagcgggca tgaagttgcc cgctgagcgc caactggcga tgcaactcgg cgtatcacgt      900

aattcactgc gcgaggcgct ggcaaaactg gtgagtgaag gcgtgctgct cagtcgacgc      960

ggcggcggga cgtttattcg ctggcgtcat gacacatggt cggagcaaaa catcgtccag     1020

ccgctaaaaa cactgatggc cgatgatccg gattacagtt tcgatattct ggaagcccgc     1080

tacgccattg aagccagcac cgcatggcat gcggcaatgc gcgccacacc tggcgacaaa     1140

gaaaagattc agctttgctt tgaagcaacg ctaagtgaag acccggatat cgcctcacaa     1200

gcggacgttc gttttcatct ggcgattgcc gaagcctcac ataacatcgt gctgctgcaa     1260

accatgcgcg gtttcttcga tgtcctgcaa tcctcagtga agcatagccg tcagcggatg     1320

tatctggtgc caccggtttt ttcacaactg accgaacaac atcaggctgt cattgacgcc     1380

atttttgccg gtgatgctga cggggcgcgt aaagcaatga tggcgcacct tagttttgtt     1440

cacaccacca tgaaacgatt cgatgaagat caggctcgcc acgcacggat tacccgcctg     1500

cccggtgagc ataatgagca ttcgagggag aaaaacgcac ttaagagatc taccatggtg     1560

agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac     1620

gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag     1680

ctgaccctga agctgatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg     1740

accaccctgg gctacggcct gcagtgcttc gcccgctacc ccgaccacat gaagcagcac     1800

gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag     1860

gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac     1920

cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg     1980

gagtacaact acaacagcca caacgtctat atcaccgccg acaagcagaa gaacggcatc     2040

aaggccaact tcaagatccg ccacaacatc gaggacggcg gcgtgcagct cgccgaccac     2100

taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg     2160

agctaccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg     2220

gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaa           2274


<210>  22
<211>  2193
<212>  DNA
<213>  Synthetic

<400>  22
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

acaagtttgt acaaaaaagc aggctccgaa ttcgcccttg gtaccatgag tgtgaaagca      780

catgaatctg tcatggattg ggtcaccgag gagctccgca gcggtcgcct aaaaatcggt      840

gaccacctcc ccagcgaacg ggcgctctcc gaaaccctcg gagtttcccg aagctccctg      900

cgcgaggcgc ttcgtgtgct cgaagccctc ggcaccattt ccaccgccac cggctccggc      960

ccgcggtctg gcaccatcat cactgctgcc cctggccagg cgctttccct ctccgtgacg     1020

ctgcagttgg tcaccaacca ggtcggccac cacgatattt atgaaacccg ccaactcctt     1080

gaaggctggg ctgccctgca ttccagcgcc gaacgtggcg actgggacgt ggcagaagcg     1140

ttgctggaaa agatggacga cccctcgcta ccgctcgagg attttttgcg tttcgacgcc     1200

gaattccacg ttgttatctc caaaggcgcg gaaaaccctc tgatcagtac gctcatggaa     1260

gccctccgtt tgtccgtggc agatcacacc gttgccaggg cccgggcgct ccccgattgg     1320

cgagccacct cggcgcgtct gcagaaagaa caccgcgcaa tcctcgcagc acttcgcgca     1380

ggcgaatcca cagtggccgc aaccttgatc aaagaacaca tcgaaggcta ctacgaagaa     1440

accgctgccg ccgaggccct taagagatct accatggtga gcaagggcga ggagctgttc     1500

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc     1560

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gctgatctgc     1620

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctggg ctacggcctg     1680

cagtgcttcg cccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg     1740

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc     1800

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc     1860

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac     1920

aacgtctata tcaccgccga caagcagaag aacggcatca aggccaactt caagatccgc     1980

cacaacatcg aggacggcgg cgtgcagctc gccgaccact accagcagaa cacccccatc     2040

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gctaccagtc cgccctgagc     2100

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg     2160

atcactctcg gcatggacga gctgtacaag taa                                  2193


<210>  23
<211>  2229
<212>  DNA
<213>  Synthetic

<400>  23
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

atgattgttt tacccagacg cctgtcagac gaggttgccg atcgtgtgcg ggcgctgatt      780

gatgaaaaaa acctggaagc gggcatgaag ttgcccgctg agcgccaact ggcgatgcaa      840

ctcggcgtat cacgtaattc actgcgcgag gcgctggcaa aactggtgag tgaaggcgtg      900

ctgctcagtc gacgcggcgg cgggacgttt attcgctggc gtcatgacac atggtcggag      960

caaaacatcg tccagccgct aaaaacactg atggccgatg atccggatta cagtttcgat     1020

attctggaag cccgctacgc cattgaagcc agcaccgcat ggcatgcggc aatgcgcgcc     1080

acacctggcg acaaagaaaa gattcagctt tgctttgaag caacgctaag tgaagacccg     1140

gatatcgcct cacaagcgga cgttcgtttt catctggcga ttgccgaagc ctcacataac     1200

atcgtgctgc tgcaaaccat gcgcggtttc ttcgatgtcc tgcaatcctc agtgaagcat     1260

agccgtcagc ggatgtatct ggtgccaccg gttttttcac aactgaccga acaacatcag     1320

gctgtcattg acgccatttt tgccggtgat gctgacgggg cgcgtaaagc aatgatggcg     1380

caccttagtt ttgttcacac caccatgaaa cgattcgatg aagatcaggc tcgccacgca     1440

cggattaccc gcctgcccgg tgagcataat gagcattcga gggagaaaaa cgcacttaag     1500

agatctacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc catcctggtc     1560

gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat     1620

gccacctacg gcaagctgac cctgaagctg atctgcacca ccggcaagct gcccgtgccc     1680

tggcccaccc tcgtgaccac cctgggctac ggcctgcagt gcttcgcccg ctaccccgac     1740

cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc     1800

accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa gttcgagggc     1860

gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga cggcaacatc     1920

ctggggcaca agctggagta caactacaac agccacaacg tctatatcac cgccgacaag     1980

cagaagaacg gcatcaaggc caacttcaag atccgccaca acatcgagga cggcggcgtg     2040

cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc     2100

gacaaccact acctgagcta ccagtccgcc ctgagcaaag accccaacga gaagcgcgat     2160

cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg     2220

tacaagtaa                                                             2229


<210>  24
<211>  2148
<212>  DNA
<213>  Synthetic

<400>  24
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

atgagtgtga aagcacatga atctgtcatg gattgggtca ccgaggagct ccgcagcggt      780

cgcctaaaaa tcggtgacca cctccccagc gaacgggcgc tctccgaaac cctcggagtt      840

tcccgaagct ccctgcgcga ggcgcttcgt gtgctcgaag ccctcggcac catttccacc      900

gccaccggct ccggcccgcg gtctggcacc atcatcactg ctgcccctgg ccaggcgctt      960

tccctctccg tgacgctgca gttggtcacc aaccaggtcg gccaccacga tatttatgaa     1020

acccgccaac tccttgaagg ctgggctgcc ctgcattcca gcgccgaacg tggcgactgg     1080

gacgtggcag aagcgttgct ggaaaagatg gacgacccct cgctaccgct cgaggatttt     1140

ttgcgtttcg acgccgaatt ccacgttgtt atctccaaag gcgcggaaaa ccctctgatc     1200

agtacgctca tggaagccct ccgtttgtcc gtggcagatc acaccgttgc cagggcccgg     1260

gcgctccccg attggcgagc cacctcggcg cgtctgcaga aagaacaccg cgcaatcctc     1320

gcagcacttc gcgcaggcga atccacagtg gccgcaacct tgatcaaaga acacatcgaa     1380

ggctactacg aagaaaccgc tgccgccgag gcccttaaga gatctaccat ggtgagcaag     1440

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac     1500

ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc     1560

ctgaagctga tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc     1620

ctgggctacg gcctgcagtg cttcgcccgc taccccgacc acatgaagca gcacgacttc     1680

ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac     1740

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc     1800

gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac     1860

aactacaaca gccacaacgt ctatatcacc gccgacaagc agaagaacgg catcaaggcc     1920

aacttcaaga tccgccacaa catcgaggac ggcggcgtgc agctcgccga ccactaccag     1980

cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagctac     2040

cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc     2100

gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaa                  2148


<210>  25
<211>  2082
<212>  DNA
<213>  Synthetic

<400>  25
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

acaagtttgt acaaaaaagc aggctccgaa ttcgcccttg gtaccgagca aaacatcgtc      780

cagccgctaa aaacactgat ggccgatgat ccggattaca gtttcgatat tctggaagcc      840

cgctacgcca ttgaagccag caccgcatgg catgcggcaa tgcgcgccac acctggcgac      900

aaagaaaaga ttcagctttg ctttgaagca acgctaagtg aagacccgga tatcgcctca      960

caagcggacg ttcgttttca tctggcgatt gccgaagcct cacataacat cgtgctgctg     1020

caaaccatgc gcggtttctt cgatgtcctg caatcctcag tgaagcatag ccgtcagcgg     1080

atgtatctgg tgccaccggt tttttcacaa ctgaccgaac aacatcaggc tgtcattgac     1140

gccatttttg ccggtgatgc tgacggggcg cgtaaagcaa tgatggcgca ccttagtttt     1200

gttcacacca ccatgaaacg attcgatgaa gatcaggctc gccacgcacg gattacccgc     1260

ctgcccggtg agcataatga gcattcgagg gagaaaaacg cacttaagaa gggcgaattc     1320

gacccagctt tcttgtacaa agtggtgctt aagagatcta ccatggtgag caagggcgag     1380

gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac     1440

aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag     1500

ctgatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgggc     1560

tacggcctgc agtgcttcgc ccgctacccc gaccacatga agcagcacga cttcttcaag     1620

tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac     1680

tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg     1740

aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac     1800

aacagccaca acgtctatat caccgccgac aagcagaaga acggcatcaa ggccaacttc     1860

aagatccgcc acaacatcga ggacggcggc gtgcagctcg ccgaccacta ccagcagaac     1920

acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag ctaccagtcc     1980

gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc     2040

gccgccggga tcactctcgg catggacgag ctgtacaagt aa                        2082


<210>  26
<211>  2010
<212>  DNA
<213>  Synthetic

<400>  26
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

acaagtttgt acaaaaaagc aggctccgaa ttcgcccttg gtaccggcca ggcgctttcc      780

ctctccgtga cgctgcagtt ggtcaccaac caggtcggcc accacgatat ttatgaaacc      840

cgccaactcc ttgaaggctg ggctgccctg cattccagcg ccgaacgtgg cgactgggac      900

gtggcagaag cgttgctgga aaagatggac gacccctcgc taccgctcga ggattttttg      960

cgtttcgacg ccgaattcca cgttgttatc tccaaaggcg cggaaaaccc tctgatcagt     1020

acgctcatgg aagccctccg tttgtccgtg gcagatcaca ccgttgccag ggcccgggcg     1080

ctccccgatt ggcgagccac ctcggcgcgt ctgcagaaag aacaccgcgc aatcctcgca     1140

gcacttcgcg caggcgaatc cacagtggcc gcaaccttga tcaaagaaca catcgaaggc     1200

tactacgaag aaaccgctgc cgccgaggcc cttaagaagg gcgaattcga cccagctttc     1260

ttgtacaaag tggtgcttaa gagatctacc atggtgagca agggcgagga gctgttcacc     1320

ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg     1380

tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagct gatctgcacc     1440

accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgggcta cggcctgcag     1500

tgcttcgccc gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc     1560

gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc     1620

gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac     1680

ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac     1740

gtctatatca ccgccgacaa gcagaagaac ggcatcaagg ccaacttcaa gatccgccac     1800

aacatcgagg acggcggcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc     1860

gacggccccg tgctgctgcc cgacaaccac tacctgagct accagtccgc cctgagcaaa     1920

gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc     1980

actctcggca tggacgagct gtacaagtaa                                      2010


<210>  27
<211>  2037
<212>  DNA
<213>  Synthetic

<400>  27
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

gagcaaaaca tcgtccagcc gctaaaaaca ctgatggccg atgatccgga ttacagtttc      780

gatattctgg aagcccgcta cgccattgaa gccagcaccg catggcatgc ggcaatgcgc      840

gccacacctg gcgacaaaga aaagattcag ctttgctttg aagcaacgct aagtgaagac      900

ccggatatcg cctcacaagc ggacgttcgt tttcatctgg cgattgccga agcctcacat      960

aacatcgtgc tgctgcaaac catgcgcggt ttcttcgatg tcctgcaatc ctcagtgaag     1020

catagccgtc agcggatgta tctggtgcca ccggtttttt cacaactgac cgaacaacat     1080

caggctgtca ttgacgccat ttttgccggt gatgctgacg gggcgcgtaa agcaatgatg     1140

gcgcacctta gttttgttca caccaccatg aaacgattcg atgaagatca ggctcgccac     1200

gcacggatta cccgcctgcc cggtgagcat aatgagcatt cgagggagaa aaacgcactt     1260

aagaagggcg aattcgaccc agctttcttg tacaaagtgg tgcttaagag atctaccatg     1320

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc     1380

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc     1440

aagctgaccc tgaagctgat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc     1500

gtgaccaccc tgggctacgg cctgcagtgc ttcgcccgct accccgacca catgaagcag     1560

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc     1620

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg     1680

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag     1740

ctggagtaca actacaacag ccacaacgtc tatatcaccg ccgacaagca gaagaacggc     1800

atcaaggcca acttcaagat ccgccacaac atcgaggacg gcggcgtgca gctcgccgac     1860

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     1920

ctgagctacc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg     1980

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaa        2037


<210>  28
<211>  1965
<212>  DNA
<213>  Synthetic

<400>  28
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

ggccaggcgc tttccctctc cgtgacgctg cagttggtca ccaaccaggt cggccaccac      780

gatatttatg aaacccgcca actccttgaa ggctgggctg ccctgcattc cagcgccgaa      840

cgtggcgact gggacgtggc agaagcgttg ctggaaaaga tggacgaccc ctcgctaccg      900

ctcgaggatt ttttgcgttt cgacgccgaa ttccacgttg ttatctccaa aggcgcggaa      960

aaccctctga tcagtacgct catggaagcc ctccgtttgt ccgtggcaga tcacaccgtt     1020

gccagggccc gggcgctccc cgattggcga gccacctcgg cgcgtctgca gaaagaacac     1080

cgcgcaatcc tcgcagcact tcgcgcaggc gaatccacag tggccgcaac cttgatcaaa     1140

gaacacatcg aaggctacta cgaagaaacc gctgccgccg aggcccttaa gaagggcgaa     1200

ttcgacccag ctttcttgta caaagtggtg cttaagagat ctaccatggt gagcaagggc     1260

gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc     1320

cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg     1380

aagctgatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg     1440

ggctacggcc tgcagtgctt cgcccgctac cccgaccaca tgaagcagca cgacttcttc     1500

aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc     1560

aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag     1620

ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac     1680

tacaacagcc acaacgtcta tatcaccgcc gacaagcaga agaacggcat caaggccaac     1740

ttcaagatcc gccacaacat cgaggacggc ggcgtgcagc tcgccgacca ctaccagcag     1800

aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagctaccag     1860

tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg     1920

accgccgccg ggatcactct cggcatggac gagctgtaca agtaa                     1965


<210>  29
<211>  2037
<212>  DNA
<213>  Synthetic

<400>  29
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

acaagtttgt acaaaaaagc aggctccgaa ttcgcccttg gtaccgagca aaacatcgtc      780

cagccgctaa aaacactgat ggccgatgat ccggattaca gtttcgatat tctggaagcc      840

cgctacgcca ttgaagccag caccgcatgg catgcggcaa tgcgcgccac acctggcgac      900

aaagaaaaga ttcagctttg ctttgaagca acgctaagtg aagacccgga tatcgcctca      960

caagcggacg ttcgttttca tctggcgatt gccgaagcct cacataacat cgtgctgctg     1020

caaaccatgc gcggtttctt cgatgtcctg caatcctcag tgaagcatag ccgtcagcgg     1080

atgtatctgg tgccaccggt tttttcacaa ctgaccgaac aacatcaggc tgtcattgac     1140

gccatttttg ccggtgatgc tgacggggcg cgtaaagcaa tgatggcgca ccttagtttt     1200

gttcacacca ccatgaaacg attcgatgaa gatcaggctc gccacgcacg gattacccgc     1260

ctgcccggtg agcataatga gcattcgagg gagaaaaacg cacttaagag atctaccatg     1320

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc     1380

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc     1440

aagctgaccc tgaagctgat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc     1500

gtgaccaccc tgggctacgg cctgcagtgc ttcgcccgct accccgacca catgaagcag     1560

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc     1620

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg     1680

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag     1740

ctggagtaca actacaacag ccacaacgtc tatatcaccg ccgacaagca gaagaacggc     1800

atcaaggcca acttcaagat ccgccacaac atcgaggacg gcggcgtgca gctcgccgac     1860

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     1920

ctgagctacc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg     1980

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaa        2037


<210>  30
<211>  1965
<212>  DNA
<213>  Synthetic

<400>  30
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

acaagtttgt acaaaaaagc aggctccgaa ttcgcccttg gtaccggcca ggcgctttcc      780

ctctccgtga cgctgcagtt ggtcaccaac caggtcggcc accacgatat ttatgaaacc      840

cgccaactcc ttgaaggctg ggctgccctg cattccagcg ccgaacgtgg cgactgggac      900

gtggcagaag cgttgctgga aaagatggac gacccctcgc taccgctcga ggattttttg      960

cgtttcgacg ccgaattcca cgttgttatc tccaaaggcg cggaaaaccc tctgatcagt     1020

acgctcatgg aagccctccg tttgtccgtg gcagatcaca ccgttgccag ggcccgggcg     1080

ctccccgatt ggcgagccac ctcggcgcgt ctgcagaaag aacaccgcgc aatcctcgca     1140

gcacttcgcg caggcgaatc cacagtggcc gcaaccttga tcaaagaaca catcgaaggc     1200

tactacgaag aaaccgctgc cgccgaggcc cttaagagat ctaccatggt gagcaagggc     1260

gaggagctgt tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc     1320

cacaagttca gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg     1380

aagctgatct gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg     1440

ggctacggcc tgcagtgctt cgcccgctac cccgaccaca tgaagcagca cgacttcttc     1500

aagtccgcca tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc     1560

aactacaaga cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag     1620

ctgaagggca tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac     1680

tacaacagcc acaacgtcta tatcaccgcc gacaagcaga agaacggcat caaggccaac     1740

ttcaagatcc gccacaacat cgaggacggc ggcgtgcagc tcgccgacca ctaccagcag     1800

aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagctaccag     1860

tccgccctga gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg     1920

accgccgccg ggatcactct cggcatggac gagctgtaca agtaa                     1965


<210>  31
<211>  1992
<212>  DNA
<213>  Synthetic

<400>  31
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

gagcaaaaca tcgtccagcc gctaaaaaca ctgatggccg atgatccgga ttacagtttc      780

gatattctgg aagcccgcta cgccattgaa gccagcaccg catggcatgc ggcaatgcgc      840

gccacacctg gcgacaaaga aaagattcag ctttgctttg aagcaacgct aagtgaagac      900

ccggatatcg cctcacaagc ggacgttcgt tttcatctgg cgattgccga agcctcacat      960

aacatcgtgc tgctgcaaac catgcgcggt ttcttcgatg tcctgcaatc ctcagtgaag     1020

catagccgtc agcggatgta tctggtgcca ccggtttttt cacaactgac cgaacaacat     1080

caggctgtca ttgacgccat ttttgccggt gatgctgacg gggcgcgtaa agcaatgatg     1140

gcgcacctta gttttgttca caccaccatg aaacgattcg atgaagatca ggctcgccac     1200

gcacggatta cccgcctgcc cggtgagcat aatgagcatt cgagggagaa aaacgcactt     1260

aagagatcta ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg     1320

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc     1380

gatgccacct acggcaagct gaccctgaag ctgatctgca ccaccggcaa gctgcccgtg     1440

ccctggccca ccctcgtgac caccctgggc tacggcctgc agtgcttcgc ccgctacccc     1500

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag     1560

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag     1620

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac     1680

atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat caccgccgac     1740

aagcagaaga acggcatcaa ggccaacttc aagatccgcc acaacatcga ggacggcggc     1800

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg     1860

cccgacaacc actacctgag ctaccagtcc gccctgagca aagaccccaa cgagaagcgc     1920

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag     1980

ctgtacaagt aa                                                         1992


<210>  32
<211>  1920
<212>  DNA
<213>  Synthetic

<400>  32
atggtgagca agggcgagga gaccacaatg ggcgtaatca agcccgacat gaagatcaag       60

ctgaagatgg agggcaacgt gaatggccac gccttcgtga tcgagggcga gggcgagggc      120

aagccctacg acggcaccaa caccatcaac ctggaggtga aggagggagc ccccctgccc      180

ttctcctacg acattctgac caccgcgttc gcctacggca acagggcctt caccaagtac      240

cccgacgaca tccccaacta cttcaagcag tccttccccg agggctactc ttgggagcgc      300

accatgacct tcgaggacaa gggcatcgtg aaggtgaagt ccgacatctc catggaggag      360

gactccttca tctacgagat acacctcaag ggcgagaact tcccccccaa cggccccgtg      420

atgcagaaga agaccaccgg ctgggacgcc tccaccgaga ggatgtacgt gcgcgacggc      480

gtgctgaagg gcgacgtcaa gcacaagctg ctgctggagg gcggcggcca ccaccgcgtt      540

gacttcaaga ccatctacag ggccaagaag gcggtgaagc tgcccgacta tcactttgtg      600

gaccaccgca tcgagatcct gaaccacgac aaggactaca acaaggtgac cgtttacgag      660

agcgccgtgg cccgcaactc caccgacggc atggacgagc tgtacaagag atctggtacc      720

ggccaggcgc tttccctctc cgtgacgctg cagttggtca ccaaccaggt cggccaccac      780

gatatttatg aaacccgcca actccttgaa ggctgggctg ccctgcattc cagcgccgaa      840

cgtggcgact gggacgtggc agaagcgttg ctggaaaaga tggacgaccc ctcgctaccg      900

ctcgaggatt ttttgcgttt cgacgccgaa ttccacgttg ttatctccaa aggcgcggaa      960

aaccctctga tcagtacgct catggaagcc ctccgtttgt ccgtggcaga tcacaccgtt     1020

gccagggccc gggcgctccc cgattggcga gccacctcgg cgcgtctgca gaaagaacac     1080

cgcgcaatcc tcgcagcact tcgcgcaggc gaatccacag tggccgcaac cttgatcaaa     1140

gaacacatcg aaggctacta cgaagaaacc gctgccgccg aggcccttaa gagatctacc     1200

atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac     1260

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac     1320

ggcaagctga ccctgaagct gatctgcacc accggcaagc tgcccgtgcc ctggcccacc     1380

ctcgtgacca ccctgggcta cggcctgcag tgcttcgccc gctaccccga ccacatgaag     1440

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc     1500

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg     1560

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac     1620

aagctggagt acaactacaa cagccacaac gtctatatca ccgccgacaa gcagaagaac     1680

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc     1740

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac     1800

tacctgagct accagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc     1860

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa     1920

