                         SEQUENCE LISTING

<110>  Yale University
       Gunel, Murat
 
<120>  Compositions and methods for diagnosing and treating neoplasia

<130>  047162-5124-00-WO.602262

<150>  US 61/755,796
<151>  2013-01-23

<150>  US 61/621,758
<151>  2012-04-09

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 
1               5                   10                  15      


Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 
            20                  25                  30          


Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 
        35                  40                  45              


Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 
    50                  55                  60                  


Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 
65                  70                  75                  80  


Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 
                85                  90                  95      


Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 
            100                 105                 110         


Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 
        115                 120                 125             


Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 
145                 150                 155                 160 


Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 
                165                 170                 175     


Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 
            180                 185                 190         


Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 
        195                 200                 205             


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 
    210                 215                 220                 


Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 
225                 230                 235                 240 


Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 
                245                 250                 255     


Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 
            260                 265                 270         


Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 
        275                 280                 285             


Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 
    290                 295                 300                 


Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 
305                 310                 315                 320 


Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 
                325                 330                 335     


Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 
            340                 345                 350         


Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 
        355                 360                 365             


Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 
    370                 375                 380                 


Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 
385                 390                 395                 400 


Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 
                405                 410                 415     


Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 
            420                 425                 430         


Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 
        435                 440                 445             


Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 
    450                 455                 460                 


Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 
465                 470                 475                 480 


Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 
                485                 490                 495     


Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 
            500                 505                 510         


Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 
        515                 520                 525             


Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 
    530                 535                 540                 


Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 
545                 550                 555                 560 


Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 
                565                 570                 575     


Ile Lys Lys Leu Thr Leu Gln Ser Ala Lys Ser Arg Val Ala Phe Phe 
            580                 585                 590         


Glu Glu Leu 
        595 


<210>  2
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Gly Lys Ser Ala Arg Tyr Asn Arg Phe Ser Gly Gly Pro 
1               5                   10                  15      


Ser Asn Leu Pro Thr Pro Asp Val Thr Thr Gly Thr Arg Met Glu Thr 
            20                  25                  30          


Thr Phe Gly Pro Ala Phe Ser Ala Val Thr Thr Ile Thr Lys Ala Asp 
        35                  40                  45              


Gly Thr Ser Thr Tyr Lys Gln His Cys Arg Thr Pro Ser Ser Ser Ser 
    50                  55                  60                  


Thr Leu Ala Tyr Ser Pro Arg Asp Glu Glu Asp Ser Met Pro Pro Ile 
65                  70                  75                  80  


Ser Thr Pro Arg Arg Ser Asp Ser Ala Ile Ser Val Arg Ser Leu His 
                85                  90                  95      


Ser Glu Ser Ser Met Ser Leu Arg Ser Thr Phe Ser Leu Pro Glu Glu 
            100                 105                 110         


Glu Glu Glu Pro Glu Pro Leu Val Phe Ala Glu Gln Pro Ser Val Lys 
        115                 120                 125             


Leu Cys Cys Gln Leu Cys Cys Ser Val Phe Lys Asp Pro Val Ile Thr 
    130                 135                 140                 


Thr Cys Gly His Thr Phe Cys Arg Arg Cys Ala Leu Lys Ser Glu Lys 
145                 150                 155                 160 


Cys Pro Val Asp Asn Val Lys Leu Thr Val Val Val Asn Asn Ile Ala 
                165                 170                 175     


Val Ala Glu Gln Ile Gly Glu Leu Phe Ile His Cys Arg His Gly Cys 
            180                 185                 190         


Arg Val Ala Gly Ser Gly Lys Pro Pro Ile Phe Glu Val Asp Pro Arg 
        195                 200                 205             


Gly Cys Pro Phe Thr Ile Lys Leu Ser Ala Arg Lys Asp His Glu Gly 
    210                 215                 220                 


Ser Cys Asp Tyr Arg Pro Val Arg Cys Pro Asn Asn Pro Ser Cys Pro 
225                 230                 235                 240 


Pro Leu Leu Arg Met Asn Leu Glu Ala His Leu Lys Glu Cys Glu His 
                245                 250                 255     


Ile Lys Cys Pro His Ser Lys Tyr Gly Cys Thr Phe Ile Gly Asn Gln 
            260                 265                 270         


Asp Thr Tyr Glu Thr His Leu Glu Thr Cys Arg Phe Glu Gly Leu Lys 
        275                 280                 285             


Glu Phe Leu Gln Gln Thr Asp Asp Arg Phe His Glu Met His Val Ala 
    290                 295                 300                 


Leu Ala Gln Lys Asp Gln Glu Ile Ala Phe Leu Arg Ser Met Leu Gly 
305                 310                 315                 320 


Lys Leu Ser Glu Lys Ile Asp Gln Leu Glu Lys Ser Leu Glu Leu Lys 
                325                 330                 335     


Phe Asp Val Leu Asp Glu Asn Gln Ser Lys Leu Ser Glu Asp Leu Met 
            340                 345                 350         


Glu Phe Arg Arg Asp Ala Ser Met Leu Asn Asp Glu Leu Ser His Ile 
        355                 360                 365             


Asn Ala Arg Leu Asn Met Gly Ile Leu Gly Ser Tyr Asp Pro Gln Gln 
    370                 375                 380                 


Ile Phe Lys Cys Lys Gly Thr Phe Val Gly His Gln Gly Pro Val Trp 
385                 390                 395                 400 


Cys Leu Cys Val Tyr Ser Met Gly Asp Leu Leu Phe Ser Gly Ser Ser 
                405                 410                 415     


Asp Lys Thr Ile Lys Val Trp Asp Thr Cys Thr Thr Tyr Lys Cys Gln 
            420                 425                 430         


Lys Thr Leu Glu Gly His Asp Gly Ile Val Leu Ala Leu Cys Ile Gln 
        435                 440                 445             


Gly Cys Lys Leu Tyr Ser Gly Ser Ala Asp Cys Thr Ile Ile Val Trp 
    450                 455                 460                 


Asp Ile Gln Asn Leu Gln Lys Val Asn Thr Ile Arg Ala His Asp Asn 
465                 470                 475                 480 


Pro Val Cys Thr Leu Val Ser Ser His Asn Val Leu Phe Ser Gly Ser 
                485                 490                 495     


Leu Lys Ala Ile Lys Val Trp Asp Ile Val Gly Thr Glu Leu Lys Leu 
            500                 505                 510         


Lys Lys Glu Leu Thr Gly Leu Asn His Trp Val Arg Ala Leu Val Ala 
        515                 520                 525             


Ala Gln Ser Tyr Leu Tyr Ser Gly Ser Tyr Gln Thr Ile Lys Ile Trp 
    530                 535                 540                 


Asp Ile Arg Thr Leu Asp Cys Ile His Val Leu Gln Thr Ser Gly Gly 
545                 550                 555                 560 


Ser Val Tyr Ser Ile Ala Val Thr Asn His His Ile Val Cys Gly Thr 
                565                 570                 575     


Tyr Glu Asn Leu Ile His Val Trp Asp Ile Glu Ser Lys Glu Gln Val 
            580                 585                 590         


Arg Thr Leu Thr Gly His Val Gly Thr Val Tyr Ala Leu Ala Val Ile 
        595                 600                 605             


Ser Thr Pro Asp Gln Thr Lys Val Phe Ser Ala Ser Tyr Asp Arg Ser 
    610                 615                 620                 


Leu Arg Val Trp Ser Met Asp Asn Met Ile Cys Thr Gln Thr Leu Leu 
625                 630                 635                 640 


Arg His Gln Gly Ser Val Thr Ala Leu Ala Val Ser Arg Gly Arg Leu 
                645                 650                 655     


Phe Ser Gly Ala Val Asp Ser Thr Val Lys Val Trp Thr Cys 
            660                 665                 670 


<210>  3
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210>  4
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu 
        355                 360                 365             


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
    370                 375                 380                 


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
385                 390                 395                 400 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
                405                 410                 415     


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
            420                 425                 430         


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
        435                 440                 445             


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
465                 470                 475                 


<210>  5
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Ala Arg Pro Ala Arg Gly Pro Glu Leu Pro Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Asp Pro Gly Arg Gly Ala Ala Ser 
            20                  25                  30          


Ser Gly Asn Ala Thr Gly Pro Gly Pro Arg Ser Ala Gly Gly Ser Ala 
        35                  40                  45              


Arg Arg Ser Ala Ala Val Thr Gly Pro Pro Pro Pro Leu Ser His Cys 
    50                  55                  60                  


Gly Arg Ala Ala Pro Cys Glu Pro Leu Arg Tyr Asn Val Cys Leu Gly 
65                  70                  75                  80  


Ser Val Leu Pro Tyr Gly Ala Thr Ser Thr Leu Leu Ala Gly Asp Ser 
                85                  90                  95      


Asp Ser Gln Glu Glu Ala His Gly Lys Leu Val Leu Trp Ser Gly Leu 
            100                 105                 110         


Arg Asn Ala Pro Arg Cys Trp Ala Val Ile Gln Pro Leu Leu Cys Ala 
        115                 120                 125             


Val Tyr Met Pro Lys Cys Glu Asn Asp Arg Val Glu Leu Pro Ser Arg 
    130                 135                 140                 


Thr Leu Cys Gln Ala Thr Arg Gly Pro Cys Ala Ile Val Glu Arg Glu 
145                 150                 155                 160 


Arg Gly Trp Pro Asp Phe Leu Arg Cys Thr Pro Asp Arg Phe Pro Glu 
                165                 170                 175     


Gly Cys Thr Asn Glu Val Gln Asn Ile Lys Phe Asn Ser Ser Gly Gln 
            180                 185                 190         


Cys Glu Val Pro Leu Val Arg Thr Asp Asn Pro Lys Ser Trp Tyr Glu 
        195                 200                 205             


Asp Val Glu Gly Cys Gly Ile Gln Cys Gln Asn Pro Leu Phe Thr Glu 
    210                 215                 220                 


Ala Glu His Gln Asp Met His Ser Tyr Ile Ala Ala Phe Gly Ala Val 
225                 230                 235                 240 


Thr Gly Leu Cys Thr Leu Phe Thr Leu Ala Thr Phe Val Ala Asp Trp 
                245                 250                 255     


Arg Asn Ser Asn Arg Tyr Pro Ala Val Ile Leu Phe Tyr Val Asn Ala 
            260                 265                 270         


Cys Phe Phe Val Gly Ser Ile Gly Trp Leu Ala Gln Phe Met Asp Gly 
        275                 280                 285             


Ala Arg Arg Glu Ile Val Cys Arg Ala Asp Gly Thr Met Arg Leu Gly 
    290                 295                 300                 


Glu Pro Thr Ser Asn Glu Thr Leu Ser Cys Val Ile Ile Phe Val Ile 
305                 310                 315                 320 


Val Tyr Tyr Ala Leu Met Ala Gly Val Val Trp Phe Val Val Leu Thr 
                325                 330                 335     


Tyr Ala Trp His Thr Ser Phe Lys Ala Leu Gly Thr Thr Tyr Gln Pro 
            340                 345                 350         


Leu Ser Gly Lys Thr Ser Tyr Phe His Leu Leu Thr Trp Ser Leu Pro 
        355                 360                 365             


Phe Val Leu Thr Val Ala Ile Leu Ala Val Ala Gln Val Asp Gly Asp 
    370                 375                 380                 


Ser Val Ser Gly Ile Cys Phe Val Gly Tyr Lys Asn Tyr Arg Tyr Arg 
385                 390                 395                 400 


Ala Gly Phe Val Leu Ala Pro Ile Gly Leu Val Leu Ile Val Gly Gly 
                405                 410                 415     


Tyr Phe Leu Ile Arg Gly Val Met Thr Leu Phe Ser Ile Lys Ser Asn 
            420                 425                 430         


His Pro Gly Leu Leu Ser Glu Lys Ala Ala Ser Lys Ile Asn Glu Thr 
        435                 440                 445             


Met Leu Arg Leu Gly Ile Phe Gly Phe Leu Ala Phe Gly Phe Val Leu 
    450                 455                 460                 


Ile Thr Phe Ser Cys His Phe Tyr Asp Phe Phe Asn Gln Ala Glu Trp 
465                 470                 475                 480 


Glu Arg Ser Phe Arg Asp Tyr Val Leu Cys Gln Ala Asn Val Thr Ile 
                485                 490                 495     


Gly Leu Pro Thr Lys Gln Pro Ile Pro Asp Cys Glu Ile Lys Asn Arg 
            500                 505                 510         


Pro Ser Leu Leu Val Glu Lys Ile Asn Leu Phe Ala Met Phe Gly Thr 
        515                 520                 525             


Gly Ile Ala Met Ser Thr Trp Val Trp Thr Lys Ala Thr Leu Leu Ile 
    530                 535                 540                 


Trp Arg Arg Thr Trp Cys Arg Leu Thr Gly Gln Ser Asp Asp Glu Pro 
545                 550                 555                 560 


Lys Arg Ile Lys Lys Ser Lys Met Ile Ala Lys Ala Phe Ser Lys Arg 
                565                 570                 575     


His Glu Leu Leu Gln Asn Pro Gly Gln Glu Leu Ser Phe Ser Met His 
            580                 585                 590         


Thr Val Ser His Asp Gly Pro Val Ala Gly Leu Ala Phe Asp Leu Asn 
        595                 600                 605             


Glu Pro Ser Ala Asp Val Ser Ser Ala Trp Ala Gln His Val Thr Lys 
    610                 615                 620                 


Met Val Ala Arg Arg Gly Ala Ile Leu Pro Gln Asp Ile Ser Val Thr 
625                 630                 635                 640 


Pro Val Ala Thr Pro Val Pro Pro Glu Glu Gln Ala Asn Leu Trp Leu 
                645                 650                 655     


Val Glu Ala Glu Ile Ser Pro Glu Leu Gln Lys Arg Leu Gly Arg Lys 
            660                 665                 670         


Lys Lys Arg Arg Lys Arg Lys Lys Glu Val Cys Pro Leu Ala Pro Pro 
        675                 680                 685             


Pro Glu Leu His Pro Pro Ala Pro Ala Pro Ser Thr Ile Pro Arg Leu 
    690                 695                 700                 


Pro Gln Leu Pro Arg Gln Lys Cys Leu Val Ala Ala Gly Ala Trp Gly 
705                 710                 715                 720 


Ala Gly Asp Ser Cys Arg Gln Gly Ala Trp Thr Leu Val Ser Asn Pro 
                725                 730                 735     


Phe Cys Pro Glu Pro Ser Pro Pro Gln Asp Pro Phe Leu Pro Ser Ala 
            740                 745                 750         


Pro Ala Pro Val Ala Trp Ala His Gly Arg Arg Gln Gly Leu Gly Pro 
        755                 760                 765             


Ile His Ser Arg Thr Asn Leu Met Asp Thr Glu Leu Met Asp Ala Asp 
    770                 775                 780                 


Ser Asp Phe 
785         


<210>  6
<211>  1068
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Met  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210>  7
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
1               5                   10                  15      


Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
        35                  40                  45              


Arg Pro Glu Glu Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
    50                  55                  60                  


Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
65                  70                  75                  80  


Lys Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                85                  90                  95      


Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Val Glu Gln Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Ile Ala 
        115                 120                 125             


Pro Pro Leu Leu Ile Lys Leu Val Glu Ala Ile Glu Lys Lys Gly Leu 
    130                 135                 140                 


Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Leu Ala Glu 
145                 150                 155                 160 


Leu Arg Gln Leu Leu Asp Cys Asp Thr Pro Ser Val Asp Leu Glu Met 
                165                 170                 175     


Ile Asp Val His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Leu Asp 
            180                 185                 190         


Leu Pro Asn Pro Val Ile Pro Ala Ala Val Tyr Ser Glu Met Ile Ser 
        195                 200                 205             


Leu Ala Pro Glu Val Gln Ser Ser Glu Glu Tyr Ile Gln Leu Leu Lys 
    210                 215                 220                 


Lys Leu Ile Arg Ser Pro Ser Ile Pro His Gln Tyr Trp Leu Thr Leu 
225                 230                 235                 240 


Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Thr Ser Ser Lys 
                245                 250                 255     


Asn Leu Leu Asn Ala Arg Val Leu Ser Glu Ile Phe Ser Pro Met Leu 
            260                 265                 270         


Phe Arg Phe Ser Ala Ala Ser Ser Asp Asn Thr Glu Asn Leu Ile Lys 
        275                 280                 285             


Val Ile Glu Ile Leu Ile Ser Thr Glu Trp Asn Glu Arg Gln Pro Ala 
    290                 295                 300                 


Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Thr Val Ala Asn Asn 
305                 310                 315                 320 


Gly Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                325                 330                 335     


Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
            340                 345                 350         


Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
        355                 360                 365             


Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
    370                 375                 380                 


His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Ser Ser 
385                 390                 395                 400 


Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                405                 410                 415     


Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
            420                 425                 430         


Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
        435                 440                 445             


Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
    450                 455                 460                 


Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
465                 470                 475                 480 


Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu 
                485                 490                 495     


Gln Cys Gln Thr Gln Glu Arg Tyr Ser Lys Glu Tyr Ile Glu Lys Phe 
            500                 505                 510         


Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn Tyr 
        515                 520                 525             


Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
    530                 535                 540                 


Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
545                 550                 555                 560 


Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                565                 570                 575     


Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
            580                 585                 590         


Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
        595                 600                 605             


Leu Val Glu Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
    610                 615                 620                 


Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
625                 630                 635                 640 


Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                645                 650                 655     


Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
            660                 665                 670         


Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
        675                 680                 685             


Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
    690                 695                 700                 


Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
705                 710                 715                 720 


Gln Gln Arg Arg 
                


<210>  8
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  9
<211>  2442
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
                405                 410                 415     


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
            420                 425                 430         


Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser 
        435                 440                 445             


Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln 
    450                 455                 460                 


Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser 
465                 470                 475                 480 


Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro 
                485                 490                 495     


Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro 
            500                 505                 510         


Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro 
        515                 520                 525             


Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn 
    530                 535                 540                 


Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro 
545                 550                 555                 560 


Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr 
                565                 570                 575     


Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp 
            580                 585                 590         


His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu 
        595                 600                 605             


Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg 
    610                 615                 620                 


Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met 
625                 630                 635                 640 


Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu 
                645                 650                 655     


Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg 
            660                 665                 670         


Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro 
        675                 680                 685             


Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro 
    690                 695                 700                 


Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly 
705                 710                 715                 720 


Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln 
                725                 730                 735     


Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln 
            740                 745                 750         


Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg 
        755                 760                 765             


Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met 
    770                 775                 780                 


Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro 
785                 790                 795                 800 


Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln 
                805                 810                 815     


Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro 
            820                 825                 830         


Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val 
        835                 840                 845             


Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala 
    850                 855                 860                 


Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro 
865                 870                 875                 880 


Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly 
                885                 890                 895     


Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr 
            900                 905                 910         


Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro 
        915                 920                 925             


Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser 
    930                 935                 940                 


Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro 
945                 950                 955                 960 


Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser 
                965                 970                 975     


Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val 
            980                 985                 990         


Pro Val Leu Glu Met Lys Thr Glu  Thr Gln Ala Glu Asp  Thr Glu Pro 
        995                 1000                 1005             


Asp Pro  Gly Glu Ser Lys Gly  Glu Pro Arg Ser Glu  Met Met Glu 
    1010                 1015                 1020             


Glu Asp  Leu Gln Gly Ala Ser  Gln Val Lys Glu Glu  Thr Asp Ile 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ser Glu Pro  Met Glu Val Asp Glu  Lys Lys Pro 
    1040                 1045                 1050             


Glu Val  Lys Val Glu Val Lys  Glu Glu Glu Glu Ser  Ser Ser Asn 
    1055                 1060                 1065             


Gly Thr  Ala Ser Gln Ser Thr  Ser Pro Ser Gln Pro  Arg Lys Lys 
    1070                 1075                 1080             


Ile Phe  Lys Pro Glu Glu Leu  Arg Gln Ala Leu Met  Pro Thr Leu 
    1085                 1090                 1095             


Glu Ala  Leu Tyr Arg Gln Asp  Pro Glu Ser Leu Pro  Phe Arg Gln 
    1100                 1105                 1110             


Pro Val  Asp Pro Gln Leu Leu  Gly Ile Pro Asp Tyr  Phe Asp Ile 
    1115                 1120                 1125             


Val Lys  Asn Pro Met Asp Leu  Ser Thr Ile Lys Arg  Lys Leu Asp 
    1130                 1135                 1140             


Thr Gly  Gln Tyr Gln Glu Pro  Trp Gln Tyr Val Asp  Asp Val Trp 
    1145                 1150                 1155             


Leu Met  Phe Asn Asn Ala Trp  Leu Tyr Asn Arg Lys  Thr Ser Arg 
    1160                 1165                 1170             


Val Tyr  Lys Phe Cys Ser Lys  Leu Ala Glu Val Phe  Glu Gln Glu 
    1175                 1180                 1185             


Ile Asp  Pro Val Met Gln Ser  Leu Gly Tyr Cys Cys  Gly Arg Lys 
    1190                 1195                 1200             


Tyr Glu  Phe Ser Pro Gln Thr  Leu Cys Cys Tyr Gly  Lys Gln Leu 
    1205                 1210                 1215             


Cys Thr  Ile Pro Arg Asp Ala  Ala Tyr Tyr Ser Tyr  Gln Asn Arg 
    1220                 1225                 1230             


Tyr His  Phe Cys Glu Lys Cys  Phe Thr Glu Ile Gln  Gly Glu Asn 
    1235                 1240                 1245             


Val Thr  Leu Gly Asp Asp Pro  Ser Gln Pro Gln Thr  Thr Ile Ser 
    1250                 1255                 1260             


Lys Asp  Gln Phe Glu Lys Lys  Lys Asn Asp Thr Leu  Asp Pro Glu 
    1265                 1270                 1275             


Pro Phe  Val Asp Cys Lys Glu  Cys Gly Arg Lys Met  His Gln Ile 
    1280                 1285                 1290             


Cys Val  Leu His Tyr Asp Ile  Ile Trp Pro Ser Gly  Phe Val Cys 
    1295                 1300                 1305             


Asp Asn  Cys Leu Lys Lys Thr  Gly Arg Pro Arg Lys  Glu Asn Lys 
    1310                 1315                 1320             


Phe Ser  Ala Lys Arg Leu Gln  Thr Thr Arg Leu Gly  Asn His Leu 
    1325                 1330                 1335             


Glu Asp  Arg Val Asn Lys Phe  Leu Arg Arg Gln Asn  His Pro Glu 
    1340                 1345                 1350             


Ala Gly  Glu Val Phe Val Arg  Val Val Ala Ser Ser  Asp Lys Thr 
    1355                 1360                 1365             


Val Glu  Val Lys Pro Gly Met  Lys Ser Arg Phe Val  Asp Ser Gly 
    1370                 1375                 1380             


Glu Met  Ser Glu Ser Phe Pro  Tyr Arg Thr Lys Ala  Leu Phe Ala 
    1385                 1390                 1395             


Phe Glu  Glu Ile Asp Gly Val  Asp Val Cys Phe Phe  Gly Met His 
    1400                 1405                 1410             


Val Gln  Glu Tyr Gly Ser Asp  Cys Pro Pro Pro Asn  Thr Arg Arg 
    1415                 1420                 1425             


Val Tyr  Ile Ser Tyr Leu Asp  Ser Ile His Phe Phe  Arg Pro Arg 
    1430                 1435                 1440             


Cys Leu  Arg Thr Ala Val Tyr  His Glu Ile Leu Ile  Gly Tyr Leu 
    1445                 1450                 1455             


Glu Tyr  Val Lys Lys Leu Gly  Tyr Val Thr Gly His  Ile Trp Ala 
    1460                 1465                 1470             


Cys Pro  Pro Ser Glu Gly Asp  Asp Tyr Ile Phe His  Cys His Pro 
    1475                 1480                 1485             


Pro Asp  Gln Lys Ile Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr 
    1490                 1495                 1500             


Lys Lys  Met Leu Asp Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp 
    1505                 1510                 1515             


Tyr Lys  Asp Ile Phe Lys Gln  Ala Thr Glu Asp Arg  Leu Thr Ser 
    1520                 1525                 1530             


Ala Lys  Glu Leu Pro Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val 
    1535                 1540                 1545             


Leu Glu  Glu Ser Ile Lys Glu  Leu Glu Gln Glu Glu  Glu Glu Arg 
    1550                 1555                 1560             


Lys Lys  Glu Glu Ser Thr Ala  Ala Ser Glu Thr Thr  Glu Gly Ser 
    1565                 1570                 1575             


Gln Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1580                 1585                 1590             


Asn Lys  Asn Lys Ser Ser Ile  Ser Arg Ala Asn Lys  Lys Lys Pro 
    1595                 1600                 1605             


Ser Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1610                 1615                 1620             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  His Leu His 
    1625                 1630                 1635             


Ala Gly  Pro Val Ile Asn Thr  Leu Pro Pro Ile Val  Asp Pro Asp 
    1640                 1645                 1650             


Pro Leu  Leu Ser Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1655                 1660                 1665             


Thr Leu  Ala Arg Asp Lys His  Trp Glu Phe Ser Ser  Leu Arg Arg 
    1670                 1675                 1680             


Ser Lys  Trp Ser Thr Leu Cys  Met Leu Val Glu Leu  His Thr Gln 
    1685                 1690                 1695             


Gly Gln  Asp Arg Phe Val Tyr  Thr Cys Asn Glu Cys  Lys His His 
    1700                 1705                 1710             


Val Glu  Thr Arg Trp His Cys  Thr Val Cys Glu Asp  Tyr Asp Leu 
    1715                 1720                 1725             


Cys Ile  Asn Cys Tyr Asn Thr  Lys Ser His Ala His  Lys Met Val 
    1730                 1735                 1740             


Lys Trp  Gly Leu Gly Leu Asp  Asp Glu Gly Ser Ser  Gln Gly Glu 
    1745                 1750                 1755             


Pro Gln  Ser Lys Ser Pro Gln  Glu Ser Arg Arg Leu  Ser Ile Gln 
    1760                 1765                 1770             


Arg Cys  Ile Gln Ser Leu Val  His Ala Cys Gln Cys  Arg Asn Ala 
    1775                 1780                 1785             


Asn Cys  Ser Leu Pro Ser Cys  Gln Lys Met Lys Arg  Val Val Gln 
    1790                 1795                 1800             


His Thr  Lys Gly Cys Lys Arg  Lys Thr Asn Gly Gly  Cys Pro Val 
    1805                 1810                 1815             


Cys Lys  Gln Leu Ile Ala Leu  Cys Cys Tyr His Ala  Lys His Cys 
    1820                 1825                 1830             


Gln Glu  Asn Lys Cys Pro Val  Pro Phe Cys Leu Asn  Ile Lys His 
    1835                 1840                 1845             


Lys Leu  Arg Gln Gln Gln Ile  Gln His Arg Leu Gln  Gln Ala Gln 
    1850                 1855                 1860             


Leu Met  Arg Arg Arg Met Ala  Thr Met Asn Thr Arg  Asn Val Pro 
    1865                 1870                 1875             


Gln Gln  Ser Leu Pro Ser Pro  Thr Ser Ala Pro Pro  Gly Thr Pro 
    1880                 1885                 1890             


Thr Gln  Gln Pro Ser Thr Pro  Gln Thr Pro Gln Pro  Pro Ala Gln 
    1895                 1900                 1905             


Pro Gln  Pro Ser Pro Val Ser  Met Ser Pro Ala Gly  Phe Pro Ser 
    1910                 1915                 1920             


Val Ala  Arg Thr Gln Pro Pro  Thr Thr Val Ser Thr  Gly Lys Pro 
    1925                 1930                 1935             


Thr Ser  Gln Val Pro Ala Pro  Pro Pro Pro Ala Gln  Pro Pro Pro 
    1940                 1945                 1950             


Ala Ala  Val Glu Ala Ala Arg  Gln Ile Glu Arg Glu  Ala Gln Gln 
    1955                 1960                 1965             


Gln Gln  His Leu Tyr Arg Val  Asn Ile Asn Asn Ser  Met Pro Pro 
    1970                 1975                 1980             


Gly Arg  Thr Gly Met Gly Thr  Pro Gly Ser Gln Met  Ala Pro Val 
    1985                 1990                 1995             


Ser Leu  Asn Val Pro Arg Pro  Asn Gln Val Ser Gly  Pro Val Met 
    2000                 2005                 2010             


Pro Ser  Met Pro Pro Gly Gln  Trp Gln Gln Ala Pro  Leu Pro Gln 
    2015                 2020                 2025             


Gln Gln  Pro Met Pro Gly Leu  Pro Arg Pro Val Ile  Ser Met Gln 
    2030                 2035                 2040             


Ala Gln  Ala Ala Val Ala Gly  Pro Arg Met Pro Ser  Val Gln Pro 
    2045                 2050                 2055             


Pro Arg  Ser Ile Ser Pro Ser  Ala Leu Gln Asp Leu  Leu Arg Thr 
    2060                 2065                 2070             


Leu Lys  Ser Pro Ser Ser Pro  Gln Gln Gln Gln Gln  Val Leu Asn 
    2075                 2080                 2085             


Ile Leu  Lys Ser Asn Pro Gln  Leu Met Ala Ala Phe  Ile Lys Gln 
    2090                 2095                 2100             


Arg Thr  Ala Lys Tyr Val Ala  Asn Gln Pro Gly Met  Gln Pro Gln 
    2105                 2110                 2115             


Pro Gly  Leu Gln Ser Gln Pro  Gly Met Gln Pro Gln  Pro Gly Met 
    2120                 2125                 2130             


His Gln  Gln Pro Ser Leu Gln  Asn Leu Asn Ala Met  Gln Ala Gly 
    2135                 2140                 2145             


Val Pro  Arg Pro Gly Val Pro  Pro Gln Gln Gln Ala  Met Gly Gly 
    2150                 2155                 2160             


Leu Asn  Pro Gln Gly Gln Ala  Leu Asn Ile Met Asn  Pro Gly His 
    2165                 2170                 2175             


Asn Pro  Asn Met Ala Ser Met  Asn Pro Gln Tyr Arg  Glu Met Leu 
    2180                 2185                 2190             


Arg Arg  Gln Leu Leu Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2195                 2200                 2205             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gly Ser Ala Gly  Met Ala Gly 
    2210                 2215                 2220             


Gly Met  Ala Gly His Gly Gln  Phe Gln Gln Pro Gln  Gly Pro Gly 
    2225                 2230                 2235             


Gly Tyr  Pro Pro Ala Met Gln  Gln Gln Gln Arg Met  Gln Gln His 
    2240                 2245                 2250             


Leu Pro  Leu Gln Gly Ser Ser  Met Gly Gln Met Ala  Ala Gln Met 
    2255                 2260                 2265             


Gly Gln  Leu Gly Gln Met Gly  Gln Pro Gly Leu Gly  Ala Asp Ser 
    2270                 2275                 2280             


Thr Pro  Asn Ile Gln Gln Ala  Leu Gln Gln Arg Ile  Leu Gln Gln 
    2285                 2290                 2295             


Gln Gln  Met Lys Gln Gln Ile  Gly Ser Pro Gly Gln  Pro Asn Pro 
    2300                 2305                 2310             


Met Ser  Pro Gln Gln His Met  Leu Ser Gly Gln Pro  Gln Ala Ser 
    2315                 2320                 2325             


His Leu  Pro Gly Gln Gln Ile  Ala Thr Ser Leu Ser  Asn Gln Val 
    2330                 2335                 2340             


Arg Ser  Pro Ala Pro Val Gln  Ser Pro Arg Pro Gln  Ser Gln Pro 
    2345                 2350                 2355             


Pro His  Ser Ser Pro Ser Pro  Arg Ile Gln Pro Gln  Pro Ser Pro 
    2360                 2365                 2370             


His His  Val Ser Pro Gln Thr  Gly Ser Pro His Pro  Gly Leu Ala 
    2375                 2380                 2385             


Val Thr  Met Ala Ser Ser Ile  Asp Gln Gly His Leu  Gly Asn Pro 
    2390                 2395                 2400             


Glu Gln  Ser Ala Met Leu Pro  Gln Leu Asn Thr Pro  Ser Arg Ser 
    2405                 2410                 2415             


Ala Leu  Ser Ser Glu Leu Ser  Leu Val Gly Asp Thr  Thr Gly Asp 
    2420                 2425                 2430             


Thr Leu  Glu Lys Phe Val Glu  Gly Leu 
    2435                 2440         


<210>  10
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Gly Lys Lys Thr Lys Pro Asn Thr Lys Asp His Gly 
65                  70                  75                  80  


Tyr Thr Thr Leu Ala Thr Ser Val Thr Leu Leu Lys Ala Ser Glu Val 
                85                  90                  95      


Glu Glu Ile Leu Asp Gly Asn Asp Glu Lys Tyr Lys Ala Val Ser Ile 
            100                 105                 110         


Ser Thr Glu Pro Pro Thr Tyr Leu Arg Glu Gln Lys Ala Lys Arg Asn 
        115                 120                 125             


Ser Gln Trp Val Pro Thr Leu Pro Asn Ser Ser His His Leu Asp Ala 
    130                 135                 140                 


Val Pro Cys Ser Thr Thr Ile Asn Arg Asn Arg Met Gly Arg Asp Lys 
145                 150                 155                 160 


Lys Arg Thr Phe Pro Leu Cys Phe Asp Asp His Asp Pro Ala Val Ile 
                165                 170                 175     


His Glu Asn Ala Ser Gln Pro Glu Val Leu Val Pro Ile Arg Leu Asp 
            180                 185                 190         


Met Glu Ile Asp Gly Gln Lys Leu Arg Asp Ala Phe Thr Trp Asn Met 
        195                 200                 205             


Asn Glu Lys Leu Met Thr Pro Glu Met Phe Ser Glu Ile Leu Cys Asp 
    210                 215                 220                 


Asp Leu Asp Leu Asn Pro Leu Thr Phe Val Pro Ala Ile Ala Ser Ala 
225                 230                 235                 240 


Ile Arg Gln Gln Ile Glu Ser Tyr Pro Thr Asp Ser Ile Leu Glu Asp 
                245                 250                 255     


Gln Ser Asp Gln Arg Val Ile Ile Lys Leu Asn Ile His Val Gly Asn 
            260                 265                 270         


Ile Ser Leu Val Asp Gln Phe Glu Trp Asp Met Ser Glu Lys Glu Asn 
        275                 280                 285             


Ser Pro Glu Lys Phe Ala Leu Lys Leu Cys Ser Glu Leu Gly Leu Gly 
    290                 295                 300                 


Gly Glu Phe Val Thr Thr Ile Ala Tyr Ser Ile Arg Gly Gln Leu Ser 
305                 310                 315                 320 


Trp His Gln Lys Thr Tyr Ala Phe Ser Glu Asn Pro Leu Pro Thr Val 
                325                 330                 335     


Glu Ile Ala Ile Arg Asn Thr Gly Asp Ala Asp Gln Trp Cys Pro Leu 
            340                 345                 350         


Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg Asp Gln 
        355                 360                 365             


Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala Pro Ala 
    370                 375                 380                 


Trp 
385 


<210>  11
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg 
1               5                   10                  15      


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
            20                  25                  30          


Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
        35                  40                  45              


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln 
    50                  55                  60                  


Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp 
65                  70                  75                  80  


Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg 
                85                  90                  95      


Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr 
            180                 185                 190         


Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Asp Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Gln Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Glu Phe Phe Ile Ile Leu Glu Gly Ser Ala Ala Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Glu Asn Glu Glu Phe Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Met Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Asp Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Gln Tyr Asn Ser Phe Val Ser Leu Ser Val 
    370                 375                 380     


