                         SEQUENCE LISTING

<110>  Fondazione Telethon
       BALLABIO, Andrea
       PASTORE, Nunzia
       BRUNETTI-PIERRI, Nicola
 
<120>  TFEB gene therapy of alpha-1-antitrypsin deficiency

<130>  PCT 120221

<150>  EP12 164 785.3
<151>  2012-04-19

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  2147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  1
ctttggggag tcctaagagg gcagctggca atggacacct agcagtccct ttgagactta       60

tttcagatgg agctgtagaa agatgccatg gctcacagtg cctccctggg aagggggcag      120

agggctgccc agtgaggcct cttgcgagca ggaaatcacc agagacaagg aaagaccaga      180

ccccaggatg acctcagtta ggccttgccc gactgtcctc agagtcccat tctctgtgtc      240

ctggttcttt tagaagatca tggacctcca ggtcatttcg taaccggaat ctgcctgcgg      300

ggggttttga caagctatgg tatagtgtat gtgggggtac tgacgaattg gaagatcatg      360

gagacccctt ctcctcctcc atcattggtc tgccacatcc ctcccaggcg actcacagca      420

gagagacctt ggatgtatgt agggtgcttt aaaactccag ctgagttaca gtctctcctt      480

tctgttttca ccttaacctt ccagggatgc aaacccacga caggtttagc agcagagtgg      540

aggctggcca tgaatctcag agaaagtgct cactggaaag gctggtttag cccaggcctg      600

atgtggaggc actgagctgg acgttctagc ggggttgaca cccaacagtt tacatagggg      660

gaggccaccc ctcctgagca gtctcggtga cttgaagagg aagccgcttc ttctgtacca      720

acacagaagc tccagcgaac ccccagaatg ctggcagtgt gggtgctatg taaaagtatt      780

tacatagctt tgtagagtga gccaagccca gtctgtttgg gatgactctt cacagtgcct      840

cgaatctgtc acacgtctta gtaagcagag tcacagagtt tctgtcacat catcctcctg      900

cctacaggga agtaggccat gtccctgccc cctactctga gcccagctgt gggagccagc      960

cctgcccaat gggctctctc tgattggctt ctcactcact tctaaactcc agtgagcaac     1020

ttctctcggc tcgttcaatt ggcgtgaagg tctgtgtctt gcagagaagg ttcttcacaa     1080

ctgggataaa ggtctcgctg ctcaagtgta gcccagtaga actgccaagc cccttcccct     1140

cctctcccta gactcttgga tgcaagaaga atccaggcag ctccaagggt gattgtgtcc     1200

aacctagaat gtcttgaaaa agacattaag gggactagag aagacagggg atccaacggt     1260

tctctgcagc ccagcctgac tgacatgtaa ctcttctggt tctcaccagc cagctggacc     1320

tgcttagtat tctttctgcc tcagtttccc agcctgtacc cagggctgtc atagttccat     1380

ttcaggcagt agtaatgaat gagctgacat aaaacattta gagcaggggt cagtatgtat     1440

atagagtgat tattctatat caggcattgc ctcctcggaa tgaagcttac aatcacccct     1500

ccctctgcag ttcatcttgg ggtggccaga ggatccagca gacacctagt ggggtaacac     1560

accccagcca actcggctgt tgcagacttt gtctagaagt ttcacgtctc agagctgaat     1620

tcccttctca tgacctttgg ccgtgggagt gacacctcac agctgtggtg ttttgacaac     1680

cagcagccac tggcacacaa aatgtgcagc cagcagcata tgaagtccaa gaggcgtccc     1740

ggccagccct gtccttgacc cccacctgac aattaaggca agagcctata gtttgcatca     1800

gcaacagtca cggtcaaagt ttagtcaatc aaacgttgtg taaggactca actatggctg     1860

acacgggggc ctgaggcctc ccaacattca ttaacaacag caagttcaat cattatctcc     1920

ccaaagttta ttgtgttagg tcagttccaa accgtgctga ccatggctat gatccaaagg     1980

ccggcccctt acgtcagagg cgagcctcca ggtccagctg aggggcaggg ctgtcctccc     2040

ttctgtatac tatttaaagc gaggagggct agctaccaag cacggttggc cttccctctg     2100

ggaacacacc cttggccaac aggggaaatc cggcgagacg ctctgag                   2147


<210>  2
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  2
atcctgcgag aaggaggtgc gtcctgctgc ctgccccggc actctggctc cccagctcaa       60

ggttcaggcc ttgccccagg ccgggcctct gggtacctga ggtcttctcc cgctctgtgc      120

ccttctc                                                                127


<210>  3
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcgtcac gcatagggtt gcgcatgcag ctcatgcggg agcaggcgca gcaggaggag       60

cagcgggagc gcatgcagca acaggctgtc atgcattaca tgcagcagca gcagcagcag      120

caacagcagc agctcggagg gccgcccacc ccggccatca atacccccgt ccacttccag      180

tcgccaccac ctgtgcctgg ggaggtgttg aaggtgcagt cctacctgga gaatcccaca      240

tcctaccatc tgcagcagtc gcagcatcag aaggtgcggg agtacctgtc cgagacctat      300

gggaacaagt ttgctgccca catcagccca gcccagggct ctccgaaacc cccaccagcc      360

gcctccccag gggtgcgagc tggacacgtg ctgtcctcct ccgctggcaa cagtgctccc      420

aatagcccca tggccatgct gcacattggc tccaaccctg agagggagtt ggatgatgtc      480

attgacaaca ttatgcgtct ggacgatgtc cttggctaca tcaatcctga aatgcagatg      540

cccaacacgc tacccctgtc cagcagccac ctgaatgtgt acagcagcga cccccaggtc      600

acagcctccc tggtgggcgt caccagcagc tcctgccctg cggacctgac ccagaagcga      660

gagctcacag atgctgagag cagggccctg gccaaggagc ggcagaagaa agacaatcac      720

aacttaattg aaaggagacg aaggttcaac atcaatgacc gcatcaagga gttgggaatg      780

ctgatcccca aggccaatga cctggacgtg cgctggaaca agggcaccat cctcaaggcc      840

tctgtggatt acatccggag gatgcagaag gacctgcaaa agtccaggga gctggagaac      900

cactctcgcc gcctggagat gaccaacaag cagctctggc tccgtatcca ggagctggag      960

atgcaggctc gagtgcacgg cctccctacc acctccccgt ccggcatgaa catggctgag     1020

ctggcccagc aggtggtgaa gcaggagctg cctagcgaag agggcccagg ggaggccctg     1080

atgctggggg ctgaggtccc tgaccctgag ccactgccag ctctgccccc gcaagccccg     1140

ctgcccctgc ccacccagcc accatcccca ttccatcacc tggacttcag ccacagcctg     1200

agctttgggg gcagggagga cgagggtccc ccgggctacc ccgaacccct ggcgccgggg     1260

catggctccc cattccccag cctgtccaag aaggatctgg acctcatgct cctggacgac     1320

tcactgctac cgctggcctc tgatccactt ctgtccacca tgtcccccga ggcctccaag     1380

gccagcagcc gccggagcag cttcagcatg gaggagggcg atgtgctgtg a              1431


<210>  4
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Arg Ile Gly Leu Arg Met Gln Leu Met Arg Glu Gln Ala 
1               5                   10                  15      


Gln Gln Glu Glu Gln Arg Glu Arg Met Gln Gln Gln Ala Val Met His 
            20                  25                  30          


Tyr Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Gly Gly Pro 
        35                  40                  45              


Pro Thr Pro Ala Ile Asn Thr Pro Val His Phe Gln Ser Pro Pro Pro 
    50                  55                  60                  


Val Pro Gly Glu Val Leu Lys Val Gln Ser Tyr Leu Glu Asn Pro Thr 
65                  70                  75                  80  


Ser Tyr His Leu Gln Gln Ser Gln His Gln Lys Val Arg Glu Tyr Leu 
                85                  90                  95      


Ser Glu Thr Tyr Gly Asn Lys Phe Ala Ala His Ile Ser Pro Ala Gln 
            100                 105                 110         


Gly Ser Pro Lys Pro Pro Pro Ala Ala Ser Pro Gly Val Arg Ala Gly 
        115                 120                 125             


His Val Leu Ser Ser Ser Ala Gly Asn Ser Ala Pro Asn Ser Pro Met 
    130                 135                 140                 


Ala Met Leu His Ile Gly Ser Asn Pro Glu Arg Glu Leu Asp Asp Val 
145                 150                 155                 160 


Ile Asp Asn Ile Met Arg Leu Asp Asp Val Leu Gly Tyr Ile Asn Pro 
                165                 170                 175     


Glu Met Gln Met Pro Asn Thr Leu Pro Leu Ser Ser Ser His Leu Asn 
            180                 185                 190         


Val Tyr Ser Ser Asp Pro Gln Val Thr Ala Ser Leu Val Gly Val Thr 
        195                 200                 205             


Ser Ser Ser Cys Pro Ala Asp Leu Thr Gln Lys Arg Glu Leu Thr Asp 
    210                 215                 220                 


Ala Glu Ser Arg Ala Leu Ala Lys Glu Arg Gln Lys Lys Asp Asn His 
225                 230                 235                 240 


Asn Leu Ile Glu Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys 
                245                 250                 255     


Glu Leu Gly Met Leu Ile Pro Lys Ala Asn Asp Leu Asp Val Arg Trp 
            260                 265                 270         


Asn Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Arg Met 
        275                 280                 285             


Gln Lys Asp Leu Gln Lys Ser Arg Glu Leu Glu Asn His Ser Arg Arg 
    290                 295                 300                 


Leu Glu Met Thr Asn Lys Gln Leu Trp Leu Arg Ile Gln Glu Leu Glu 
305                 310                 315                 320 


Met Gln Ala Arg Val His Gly Leu Pro Thr Thr Ser Pro Ser Gly Met 
                325                 330                 335     


Asn Met Ala Glu Leu Ala Gln Gln Val Val Lys Gln Glu Leu Pro Ser 
            340                 345                 350         


Glu Glu Gly Pro Gly Glu Ala Leu Met Leu Gly Ala Glu Val Pro Asp 
        355                 360                 365             


Pro Glu Pro Leu Pro Ala Leu Pro Pro Gln Ala Pro Leu Pro Leu Pro 
    370                 375                 380                 


Thr Gln Pro Pro Ser Pro Phe His His Leu Asp Phe Ser His Ser Leu 
385                 390                 395                 400 


Ser Phe Gly Gly Arg Glu Asp Glu Gly Pro Pro Gly Tyr Pro Glu Pro 
                405                 410                 415     


Leu Ala Pro Gly His Gly Ser Pro Phe Pro Ser Leu Ser Lys Lys Asp 
            420                 425                 430         


Leu Asp Leu Met Leu Leu Asp Asp Ser Leu Leu Pro Leu Ala Ser Asp 
        435                 440                 445             


Pro Leu Leu Ser Thr Met Ser Pro Glu Ala Ser Lys Ala Ser Ser Arg 
    450                 455                 460                 


Arg Ser Ser Phe Ser Met Glu Glu Gly Asp Val Leu 
465                 470                 475     


<210>  5
<211>  593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5
cgcgaatcaa cctctggatt acaaaatttc tgaaagattg actggtattc ttaactatgt       60

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc      120

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga      180

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc      240

cactggttgg ggcattgcca ccacctgtca actcctttcc gggacttacg ctttccccct      300

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg      360

gctgttgggc actgacaatt ccgtggtgtt gtcggggaag ctgacgtcct ttccatggct      420

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc      480

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg      540

tcttcgcctt cgccctcaga cgactcggat ctccctttgg gccgcctccc cgc             593


<210>  6
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6
ggcgcgccga cgcgcatgct cctctagact cgaggaattc ggtaccccgg gttcgaaatc       60

gataagcttg atatcgaatt cctgcaggct cagaggcaca caggagtttc tgggctcacc      120

ctgccccctt ccaacccctc agttcccatc ctccagcagc tgtttgtgtg ctgcctctga      180

agtccacact gaacaaactt cagcctactc atgtccctaa aatgggcaaa cattgcaagc      240

agcaaacagc aaacacacag ccctccctgc ctgctgacct tggagctggg gcagaggtca      300

gagacctctc tgggcccatg ccacctccaa catccactcg accccttgga atttcggtgg      360

agaggagcag aggttgtcct ggcgtggttt aggtagtgtg agagggtccg ggttcaaaac      420

cacttgctgg gtggggagtc gtcagtaagt ggctatgccc cgaccccgaa gcctgtttcc      480

ccatctgtac aatggaaatg ataaagacgc ccatctgata gggtttttgt ggcaaataaa      540

catttggttt ttttgttttg ttttgttttg ttttttgaga tggaggtttg ctctgtcgcc      600

caggctggag tgcagtgaca caatctcatc tcaccacaac cttcccctgc ctcagcctcc      660

caagtagctg ggattacaag catgtgccac cacacctggc taattttcta tttttagtag      720

agacgggttt ctccatgttg gtcagcctca gcctcccaag taactgggat tacaggcctg      780

tgccaccaca cccggctaat tttttctatt tttgacaggg acggggtttc accatgttgg      840

tcaggctggt ctagaactcc tgacctcaaa tgatccaccc acctaggcct cccaaagtgc      900

acagattaca ggcgtgggcc accgcacctg gccaaatttt taattttttt ctagagatag      960

ggtcttactg tgttgcccag gctggtgtca aactcctggg ctcaagcaga tcctcctgcc     1020

tcagcttccc aaagtggtgg gattataggt gtgagccact gcgcccagtc agtagccccc     1080

tctttgcccc tcactgagcc ctactggatg ttcttggttg tgtgacagtt tccccatcta     1140

ttaaacagaa acccctatag cagaggggag gatgaggttg gaaaatcagg agcattgtta     1200

ttctattctt gtgggatcgg ggaagcagac atctgggtgg atgtttgggg aatgctgggc     1260

tcagttgagg aagtaggggg gcccctgggg cttacaggga ctggaagctc tgagctggcc     1320

agagggatgt tgcaatcctg ccagggtctt gtctatgctg tccctttcac aaccatcccc     1380

ctaccgccag gctgacacgt ggttgtgggg gcacaaggcc agccgaacta gagtctgagg     1440

ctgggctgag gacaccctcc ccatcagctg ccagggtcac tggcggtcaa aggcagctgg     1500

tggggaagga attggactcc agccctgggg gacggatgtg gtgatggtgg gaagcaggct     1560

tggtgccagg aggggcatca gagggtgaat aagagcagat agagtgtttg ggggaggtag     1620

ccagccaaag ggggtgaggc ccggtggaag ggaagaaggg gcatacactc agagctttgc     1680

agctgaaggt tttaattttt tgagatgggg tctcactctg tctcaccagg ctggagtgca     1740

gtggcgcaat cacagctcac tgcagcccgg gggatccgga gagctcgtcg acggcgcgcc     1800


<210>  7
<211>  629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7
aattcctgca gcccgggtgg catccctgtg acccctcccc agtgcctctc ctggccctgg       60

aagttgccac tccagtgccc accagccttg tcctaataaa attaagttgc atcattttgt      120

ctgactaggt gtccttctat aatattatgg ggtggagggg ggtggtatgg agcaaggggc      180

aagttgggaa gacaacctgt agggcctgcg gggtctattg ggaaccaagc tggagtgcag      240

tggcacaatc ttggctcact gcaatctccg cctcctgggt tcaagcgatt ctcctgcctc      300

agcctcccga gttgttggga ttccaggcat gcatgaccag gctcagctaa tttttgtttt      360

tttggtagag acggggtttc accatattgg ccaggctggt ctccaactcc taatctcagg      420

tgatctaccc accttggcct cccaaattgc tgggattaca ggcgtgaacc actgctccct      480

tccctgtcct tctgatttta aaataactat accagcagga ggacgtccag acacagcata      540

ggctacctgg ccatgcccaa ccggtgggac atttgagttg cttgcttggc actgtcctct      600

catgcgttgg gtccactcag tagatgcct                                        629


<210>  8
<211>  28285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8
aaacatcatc aataatatac cttattttgg attgaagcca atatgataat gagggggtgg       60

agtttgtgac gtggcgcggg gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag      120

tgtgatgttg caagtgtggc ggaacacatg taagcgacgg atgtggcaaa agtgacgttt      180

ttggtgtgcg ccggtgtaca caggaagtga caattttcgc gcggttttag gcggatgttg      240

tagtaaattt gggcgtaacc gagtaagatt tggccatttt cgcgggaaaa ctgaataaga      300

ggaagtgaaa tctgaataat tttgtgttac tcatagcgcg taatatttgt ctagggccgc      360

ggggactttg accgtttacg tggagactcg cccaggtgtt tttctcaggt gttttccgcg      420

ttccgggtca aagttggcgt tttgatatca agcttatcga taccgtaaac aagtctttaa      480

ttcaagcaag actttaacaa gttaaaagga gcttatgggt aggaagtagt gttatgatgt      540

atgggcataa agggttttaa tgggatagtg aaaatgtcta taataatact taaatggctg      600

cccaatcacc tacaggattg atgtaaacat ggaaaaggtc aaaaacttgg gtcactaaaa      660

tagatgatta atggagagga tgaggttgat agttaaatgt agataagtgg tcttattctc      720

aataaaaatg tgaacataag gcgagtttct acaaagatgg acaggactca ttcatgaaac      780

agcaaaaact ggacatttgt tctaatcttt gaagagtatg aaaaattcct attttaaagg      840

taaaacagta actcacagga aataccaacc caacataaaa tcagaaacaa tagtctaaag      900

taataaaaat caaacgtttg cacgatcaaa ttatgaatga aattcactac taaaattcac      960

actgattttg tttcatccac agtgtcaatg ttgtgatgca tttcaattgt gtgacacagg     1020

cagactgtgg atcaaaagtg gtttctggtg cgacttactc tcttgagtat acctgcagtc     1080

ccctttctta agtgtgttaa aaaaaaaggg ggatttcttc aattcgccaa tactctagct     1140

ctccatgtgc tttctaggaa acaagtgtta acccacctta tttgtcaaac ctagctccaa     1200

aggacttttg actccccaca aaccgatgta gctcaagaga gggtatctgt caccagtatg     1260

tatagtgaaa aaagtatccc aagtcccaac agcaattcct aaaaggagtt tatttaaaaa     1320

accacacaca cctgtaaaat aagtatatat cctccaaggt gactagtttt aaaaaaacag     1380

tattggcttt gatgtaaagt actagtgaat atgttagaaa aatctcactg taaccaagtg     1440

aaatgaaagc aagtatggtt tgcagagatt caaagaaaat ataagaaaac ctactgttgc     1500

cactaaaaag aatcatatat taaatatact cacacaatag ctcttcagtc tgataaaatc     1560

tacagtcata ggaatggatc tatcactatt tctattcagt gctttgatgt aatccagcag     1620

gtcagcaaag aatttatagc cccccttgag cacacagagg gctacaatgt gatggcctcc     1680

catctccttc atcacatctc gagcaagacg ttcagtccta cagaaataaa atcaggaatt     1740

taatagaaag tttcatacat taaactttat aacaaacacc tcttagtcat taaacttcca     1800

caccaacctg ggcaatatag tgagacccca tgcctgcaaa aaaaaaaaaa ttagccaggc     1860

atggtagcat gtacctgtag tcccagctac ttgagaggtg aggtgggaaa atcactttag     1920

tgcaggatgt tgaggctgga gtgaactgtg attgtgccac tgcactccag cctggacaat     1980

agagcaagac cttgtctcaa aaaaatgcat taaaaatttt ttttaaatct tccacgtatc     2040

acatcctttg ccctcatgtt tcataaggta aaaaatttga taccttcaaa aaaaccaagc     2100

ataccactat cataattttt tttaaatgca aataaaaaca agataccatt ttcacctatc     2160

agactggcag gttctgatta aatgaaattt tctggataat atacaatatt aagagagact     2220

gtagaaactg ggccagtggc tcatgcctgt aatcccagca ctttgggagg ctgggtaaca     2280

tggcgaaccc tgtttctaca aaataaaaat attagctggg agtggtggcg cacacctata     2340

gtcccagcta ctcaggaggc tgaggtggaa ggatcgcttg aacccaggag gttgagactg     2400

cagtgaactg tgatcattct gctgcactgc accccagcct gggcaacaga gaccttgtct     2460

caaaaaaaaa aaaaaaagag acaaattgtg aagagaaagg tactctcata taacatcagg     2520

agtataaaat gattcaactt cttagaggaa aatttggcaa taccaaaata ttcaataaac     2580

tctttcccct tgacccagaa attccacttg aataaagctg aacaagtacc aaacatgtaa     2640

aagaatgttt cttctagtac agtcggtaag aacaaaatag tgtctatcaa tagtggactg     2700

gttaaatcag ttatggtatc tccataagac agaatgctat gcaaccttta aaatatatta     2760

gatagctcta gacacactaa tattaaaagt gtccaataac atttaaaact atactcatac     2820

gttaaaatat aaatgtatat atgtactttt gcatatagta tacatgcata ggccagtgct     2880

tgagaagaaa tgtgtacaga aggctgaaag gagagaactt tagtcttctt gtttatggcc     2940

tccatagtta gaatatttta taacacaaat attttgatat tataatttta aaataaaaac     3000

acagaatagc cagacataca atgcaagcat tcaataccag gtaaggtttt tcactgtaat     3060

tgacttaaca gaaaattttc aagctagatg tgcataataa taaaaatctg accttgcctt     3120

catgtgattc agccccagtc cattaccctg tttaggactg agaaatgcaa gactctggct     3180

agagttcctt cttccatctc ccttcaatgt ttactttgtt ctggtcccta cagagtccca     3240

ctataccaca actgatacta agtaattagt aaggccctcc tcttttattt ttaataaaga     3300

agattttaga aagcatcagt tatttaataa gttggcctag tttatgttca aatagcaagt     3360

actcagaaca gctgctgatg tttgaaatta acacaagaaa aagtaaaaaa cctcatttta     3420

agatcttact tacctgtcca taattagtcc atgaggaata aacacccttt ccaaatcctc     3480

agcataatga ttaggtatgc aaaataaatc aaggtcataa cctggttcat catcactaat     3540

ctgaaaaaga aatatagctg tttcaatgag agcattacag gatacaaaca tttgattgga     3600

ttaagatgtt aaaaaataac cttagtctat cagagaaatt taggtgtaag atgatattag     3660

taactgttaa ctttgtaggt atgataatga attatgtaag aaaacaacag gccgggcggg     3720

ttggttcaca cgtgtaatcc cagcactttg ggaggctgag gcaggcagac tgcctgagct     3780

caggagttcg agaccagcct gggcaacacg gtgaaatccc gtctctacta aaaatacaaa     3840

aaaattagcc gggtgtggtg acacatgcct gtagtcccag ctacttggga ggctgaggca     3900

ggagaatcac ttgaacctgg gaggtgaagg ttgcagtgag ccaagatggc accacttcac     3960

tccagcctgg gaaacagagc aagactctgt ctctgagctg agatggcacc acttcactcc     4020

agcctgggaa acagagcaag actctgtctc aaaaaaaaca aaacacacaa acaaaaaaac     4080

aggctgggcg cggtggctca cgcctgtaat cccagcactt tgggaggccg aggcgggtgg     4140

atcacctgag gtcaggagtt ccagaccagc cttgtcaaca tggtgaaacc tccccccgcc     4200

gtctctacta aaaatacaaa aattagccag gcgtggtggc aggagcctgt aatcccagct     4260

acttgggagg ctgaggcagg agaatcgctt gtacccagaa ggcagaggtt gcactgagct     4320

gagatggcac cattgcactc cagcctgggg gacaagagcg agatttcgtc tttaaaaaac     4380

aaaaacaaaa caaaaaacca tgtaactata tgtcttagtc atcttagtca agaatgtaga     4440

agtaaagtga taagatatgg aatttccttt aggtcacaaa gagaaaaaga aaaattttaa     4500

agagctaaga caaacgcagc aaaatcttta tatttaataa tattctaaac atgggtgatg     4560

aacatacggg tattcattat actattctct ccacttttga gtatgtttga aaatttagta     4620

aaacaagttt taacacactg tagtctaaca agataaaata tcacactgaa caggaaaaac     4680

tggcatggtg tggtggctca cacttgtaat cccagtgctt tgggaggctg agacaggaga     4740

gttgcttgag gccaggagtt caagaccgac atggggaatg tagcaagacc ccgtccctac     4800

aaaaaacttt gtaaaaattt gccaggtatg gtggtgcata cctgtagtcc cagctactcg     4860

ggaggcggag gcagaaggaa tcacttgagc ccaggagttt gaggctgcag tgagctacga     4920

tcataccaca gcactccagc gtggacaaca gagtaagacc ctatctcaaa aacaaaacaa     4980

aacaaaacaa acaaaaaaaa ccacaagaaa aactgctggc tgatgcagcg gctcatgcct     5040

gtaatcccag tattttggga ggcccaggtg ggcgtatcac ctgaggtcag gagttagaga     5100

ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaaatt agccaggcat     5160

gtggcacgcg cctgtagtcc cagttactgg gaggctgaag caggaggatc acctgagccc     5220

gggaggtgga ggttgcagtg agccgagatc acaccactgc actccagcct gggtgacaca     5280

gcaataccct acctcaaaat aaaaaagaaa aagaaaagaa aagttgctgt ccccgctacc     5340

ccaatcccaa atccaaacag cctctctcat ctcacagtaa gggggaaaaa tcacccaaaa     5400

aagctaagtg atcttttgaa aacccaaact cttagaagtc taagattatt atagtcaact     5460

catgaagtgt catcataaaa gatactctaa tattatttaa gtagaaccac atattggttg     5520

tcttggtatg tctagcccct ggcatacaaa atatttaata acactgatat ggtacctgtg     5580

atgtgaaaat gtactatgag tacagcttta taaatactat atatgtacct atatacagaa     5640

aaaaatacaa caaaatcata aaagcactta tctttgaaag aggagttaca gcaattttat     5700

ttagttcttt attgctttgc tatatattct aaattttttt caatgaatat atatcacttt     5760

taaaaaaatt caatggtctt tcttataaat tatctttggc agcatgcgtt tttatatata     5820

catataaaat gtatgggaaa tttttaaagg atacattaaa ttaaagcaaa atatacaaac     5880

aaaaaatcag aatacaaaaa gataaaaaga ttgggaaggg agggagggag taaggaggaa     5940

gggtgggtgg gtatagagaa atataccaaa taatggtaag aagtggggtc ttgacacttt     6000

ctacactttt tttaaataaa aaaaattttt ttctctctct tttttttttt tagagacgaa     6060

gtctcgctat gttgcccagg ctggtcttga actcctggga tcaagagatc ctcctgcctc     6120

agcctcccaa ggtgcttgga ttacaggtgt gagccaccac gcctggtcac tttctacact     6180

ttaatatata tattttttca ttttcaatgt catttttatt agttaattta taatacccat     6240

tcaccattat attcaaagtc tatttgaaga aataaaccag aaagaatgaa atactctagc     6300

tcacatgcta ttcaatacta aattaccttt caaatcacat tcaagaagct gatgatttaa     6360

gctttggcgg tttccaataa atattggtca aaccataatt aaatctcaat atatcagtta     6420

gtacctattg agcatctcct tttacaacct aagcattgta ttaggtgctt aaatacaagc     6480

agcttgactt ttaatacatt taaaaataca tatttaagac ttaaaatctt atttatggaa     6540

ttcagttata ttttgaggtt tccagtgctg agaaatttga ggtttgtgct gtctttcagt     6600

ccccaaagct cagttctgag ttctcagact ttggtggaac ttcatgtatt gtcaggttgg     6660

cccgtaatac ctgtgggaca acttcagccc ctgtgcacat ggccaggagg ctggttgcaa     6720

acattttcag gtaggtggac caggacatgc ccctggtcat ggccaggtgg aggcatagtg     6780

ctatacagca ggcagaagtc aatattgatt tgtttttaaa gaaacatgta ctactttcat     6840

aagcagaaaa aatttctatt cttgggggaa aagattatgc cagatcctct aggattaaat     6900

gctgatgcat ctgctaaacc ttcacatatc agaacatatt tactatagaa agaatgaaaa     6960

tgggacattt gtgtgtcacc tatgtgaaca ttccaaaaat attttacaac aactaagtat     7020

tttataaatt ttatgaactg aaatttagtt caagttctag gaaaatacaa accttgctag     7080

atattataaa aatgatacaa tatatattca tttcaggctc atcagaatat atctgttatc     7140

acttgacaag aatgaaaatg caccattttg tagtgcttta aaatcaggaa gatccagagt     7200

actaaaaatg acttcttcct tgaagcttac tcaccaactt cctcccagtt actcactgct     7260

tctgccacaa gcataaacta ggacccagcc agaactccct tgaaatatac acttgcaacg     7320

attactgcat ctatcaaaat ggttcagtgc ctggctacag gttctgcaga tcgactaaga     7380

atttgaaaag tcttgtttat ttcaaaggaa gcccatgtga attctgccca gagttcatcc     7440

cagatatgca gtctaagaat acagacagat cagcagagat gtattctaaa acaggaattc     7500

tggcaatata acaaattgat ttccaatcaa aacagattta cataccatac ttatgtcaag     7560

aagttgtttt gttttattgc atcctagatt ttattttttt gatttatggt ttactttaag     7620

cataaaaaat ttgtcaatac aactcttccc aaaaggcata aacaaaaatt cataaaactt     7680

gcatcacttg agatacttca ggtatgaatt cacaactttg ttacaactta ctatatatat     7740

gcacacatat atatatattt gggtatattg ggggggttct aatttaagaa atgcataatt     7800

ggctatagac agacagttgt ctggaatgaa aatcaatact tttgctataa tcgattactg     7860

aaataatttt actttccagt aaaactggca ttataatttt ttttaatttt taaaacttca     7920

taattttttg ccagactgac ccatgtaaac atacaaatta ctaataatta tgcacgtcac     7980

atctgtaata atggccttca tgtaaacatt tttgtggttt acacataaaa tctctaatta     8040

caaagctata ttatctaaaa ttacagtaag caagaaaatt aatccaagct aagacaatac     8100

ttgcaacatc aattcatcat ctgtgacaag gactgcttaa gtctctttgt ggttaaaaag     8160

gaaaaaaaaa aaaaagacat gttggccaga tgcggtggct cacacctgta atcccagcac     8220

tttgggaggc tgaggtgggc ggatcacccc tggcctgccc aacatggtga aaccccgtct     8280

ctactaaaaa cacaaaaatt agctgggcgt ggtggcgggc gcctgtaatt ccagctactc     8340

gggaggctga ggcaggagaa ttgctagaac ccaggaggca gagattgcag tgagctgaga     8400

ttgcaccatt gcactacagt ctgggcaaca aaagtgaaac tccatcttaa aaaaaaaaag     8460

acaatgttcg tgggtccaaa caagacttaa tggaagtgag tctaaaaatg agctatgtgg     8520

gccaggcgta gtggctccca cctgtaatcc cagcactttg ggaggccgaa gcaggcagat     8580

catgaggtca ggagatggag accatcctgg ccaacacggt gaaatcctgt ctctacaaaa     8640

attagctggg cgtggtggtg cctgcctgta atcccagcta ctcagaaggc tcaggcagga     8700

gaatcgcttg aaccagggag tcggtggcta gagtgagccg agatttgcat cactgcactc     8760

ctgcctggtg acagagcaag actccatctc aaaaaaaaca aacaaaaata aaagataaaa     8820

atgagctatg tgaattaaaa gaggtataac aatagataaa ccatatttta tttaattcct     8880

agtaatgagt aatatttcca aacttctgga atgggcagaa attgctagtt ggcatatttt     8940

taccttttat attcagatac attaaaattc tcaaaaaaaa acacctcaaa gcagatgatc     9000

cgccatctcc ttggataatt tgtgttaact caggataaca gaaaaccaaa attatgagtt     9060

actgatgcaa tattcctaaa tgtaaaaata attaaagcta atagtagatt catcttccaa     9120

tttcatatca gtcttacaaa taaactacat atataacttg cttgccttcc cttctgaggg     9180

ataaagctgt tagaagaatt aaaatcagca ttcttgacta ttcaaccaag ggagggataa     9240

attattactc attctaggga catgggctca taactactac atgtgtaagg acatgaattt     9300

acccaatatt acaatttttc cttttattag tgtgtacagt ggaagaatag acatgttcac     9360

tctggacaaa aaaaaaatta tacttatcag ttatcagaag cacaatgctg aagacagtag     9420

ttccataaca atttgaagta tgtgatcgaa ctagtagatt atcttagtag tagtgaatta     9480

ttgtaaatgt tagtaatttg gcagccactg ggcagaaaaa taagaattga ggctcaatat     9540

tgatattaat ggtggtgatt gacacataaa ttttatcaag tctacacaat ataaaattac     9600

agaaaggtag aagagtatac cagtacaact tcaacatatc ttcactacaa gggagtaaaa     9660

tgacatggcc tagttactat ctaatgaact gcagaaaact aaaagaaaac tccaaggcaa     9720

ctcttctctg ctgatctggt tggtcctttt cctacctttt gcaataccca gatacaaaca     9780

atggatagaa aacaaagtag acttgtagta tgcaggtcac agtgctaaat tcacagaaag     9840

aaacccctga actgaactgc tctatttcct ggtggtcaca aagagtaatt ctggtttaca     9900

cctacagatt gatgtcaatc tacaccctgt tgataacagt gtggccaagg acaaaaaaaa     9960

ggtgctccgt tttaccaatt ctgtaaaaaa ttattggcag ggtaagctcg gctagggcag    10020

gattacattt ctaggactac catccccgaa atttagaaga tattatatcc acataaagca    10080

tatctttcac attaatttgc aaaaatctaa aagctttttc ttagctcaag tgtgtccaag    10140

tttaccctgg cagtttaaaa cgatagttac aagcagcatg ggttgtatca gacacatttg    10200

agggccaatt tcatgtaagt gatattgggc aagttacttc aactatctgt gcctccaagg    10260

tcatactagt gtttatttac ctaaagggta cctgttatgt aactttaggg tgtttacatt    10320

agataatgcc tgcaaaatat ttacttcaac gcctaaaaca tagttaagta ttcaataaat    10380

acctactatt gtcactacta acttaaaagt ttagagatta agagcagaat ctggggtgag    10440

acaaacttag gttcaaatcc tagtattgtt gggtaatctt gggcaagtta cttaacctct    10500

ctgatttgtg taatttaaaa aattagttaa tatacataac agggcttaga agagtatcta    10560

gcacatagca ccatttaagc atttgttatt gctaacatgc aaacaattta agggaaagaa    10620

attttttaaa aaggaagagg gatttgcaaa ctaaaaacaa tgagtatctt atgttcaaag    10680

aaaactaaca aacagccagc tctagcaata attaaattca ctatatactg gggcaggcat    10740

cacaccccaa agctaaaagc gtctacctag gccaggcacg gtggctcatg cctgtaatcc    10800

cagcactttg ggaagcagag gcgggcagat cgcttgagct caggagttca agaccagcct    10860

ggacaacatg gcaaaacacc atctctacaa aaaatacaaa tattaggccg ggcgcagtgg    10920

ctcacgcctg taatcccagc actttgggag gccaaggcgg gtggatcacc tgagatcagg    10980

agttcgagag tagcctggcc aacatggtga aacctcgtct ctattaaaaa tacaaaaaat    11040

tagccaggca tggtggcagg cgcctgtaat cccagctact cagggggatg aggtaggaga    11100

atcgcttgaa cccgggaggc agaggttgca ctgagccgag atcatgccac tgtactccag    11160

cccgggcaac aagagcgaaa ctccatctca aaaaataaat aaataaataa ataaaataaa    11220

gtacaaatat tagccaggga tggtggtgcg cacctgtagt cccagctact tgggaggctg    11280

aagtgggaga atcccctgag cctggggaga atcacccgag cccgggaagt cgaggctgca    11340

gtgagcagtg attgtgccac tgcactccat cctaggtgac agagtgagac cctgtctcaa    11400

aaaaaagaaa ttggcagaat taagtaagtt gatgtttaga gatgaaaaat caacattttt    11460

tcctcagcaa ctgaataaaa acaacagcca ctaccatttt tttgagtacc tatttgtagc    11520

ctatttttta actggtatta ctcgagagag agagagctag gttcgagaca gagctccttc    11580

tcttaataac tgtatgacct agggtatgtc tgttagcctc tctgaggctt caaaggttcc    11640

tcatctgtaa aatggtaata atcataccat tgctacaggg ctgttttgaa gactaattag    11700

gactatgtaa gtaaacatga tgatggctat tattactgtt ccccgccagg ggccatgcaa    11760

gggttgctga ttcacataga ctgtcttata atcctctcaa taactccaag aggtagccag    11820

cacctcagat atacataaaa tgacttaagc ccagagaggt gaagtaagtt gcccacagcc    11880

acacaactag taaatagccc aaacaagctg gattcccagt tagactccgt taatagcact    11940

gctctttacc ttaagtcatt acaatgccta atatgaaata gaatcgcttc tttcttaggg    12000

ttcaagtggt taattattta atgtattcat tcaacaaacc atcatcgagg acctcttaca    12060

agccaagtac tgtgctaagt gctagagtta cggcggtgat tcctgccctt aaaaagtttt    12120

agtgggagaa acaacaggta accaggtcat tgccaaaaca acaaaaataa tcataataaa    12180

gcaggctaaa gcatatttaa ctggccgggg ttttgactat tttagcaagc atgatcagaa    12240

cggttgagga gggaggccag cagcttggcc ggttcaacaa acaagaaaaa accagtgagg    12300

gtggagctaa gataccagag gctgattacg gttaagaatg ttcttgaagg taaggaccag    12360

attctcattt tctatatcct ggggcatcgg tcagcatgga atctggattc tagcacatgt    12420

gaatttcggc ttgaaatgac ctaatgcctt ttccctagtt ccttcgtgtg tcaaatacgc    12480

atggttaccg ctaccagagc tgtagtgggg cttcaatgag gccatgagca tctccataaa    12540

gatgaactac agtgtgtgca aaactaaagg caaaacctgg tccccacacg ccctcccagg    12600

tggtcgcttt ccgtgccgag gcccctccag aggtgccccg agaacctcac catcgcaccc    12660

caaacttcca gggaagggcc tctcccgaga aagcccccac gcccccaccc cgcgccatca    12720

ttcccgaatc tgccctcggc ccctccccgc agcacgctcg caggcggcac atgtcaacca    12780

aaacgccatt tccaccttct cttcccacac gcagtcctct tttcccaggg ctcccccgag    12840

gagggaccca ccccaaaccc cgccattccg tcctccctgc cgccctcgcg tgacgtaaag    12900

ccgaacccgg gaaactggcc gcccccgcct gcggggttcc ctgggcccgg ccgctctaga    12960

actagtggat cccaattgaa ggcctggtct aaatgactcc aaaatcacca cttaattcaa    13020

gagactgatt tccctgagtc aggcccctta aagcagctat ttcaatggga cagggaaaca    13080

accctaggat ctggattaga atcacttggg ggctgccaca cccccagggc tctgatcctg    13140

cccttctccc acacgcacat tcacatactg ctgcagtgac cttccatttc taatgggttc    13200

ctgggccatc tgtcaggtat agggaatgga aaaggggttg gggaggctct gcttcagaaa    13260

gtttgtgtca ggggctccca gagcctccac agatagatag caggggtccc caccctacca    13320

tggcagctat aaatgtgatc aacatttatt ggcctaggat acagcagtta gcaaaatgcc    13380

tgatgtagtt cccactccgt ggaggttgca ggctagctct ttcctaatga gctttacagc    13440

agaagctgtt ttatcgttaa gtgccccaca gagacacttt accaggaggc tgggagagtt    13500

ctccagattt gggagaggcg cagagacagt gtgtgagccg agccctgtct cagcaatcca    13560

cctggaggag ctagagtatc ctcctccctt taccattcag accgagagaa aaagcccagc    13620

ttgtgtgcac cctcgtgggg ttaaggcgag ctgttcctgg tttaaagcct ttcagtattt    13680

gttttgatgt aaggctctgt ggtttggggg ggaacatctg taaacattat tagttgattt    13740

ggggtttgtc tttgatggtt tctatctgca attatcgtca tgtatattta agtgtctgtt    13800

atagaaaacc cacacccact gtcctgtaaa cttttctcag tgtccagact ttctgtaatc    13860

acattttaat tgccacctcg tatttcacct ctacatttga aatctggcgt ctgtttcaag    13920

ccagtgtgtt ttttcttcgt tctgtaataa acagccagga gaaaagtgcc tctatgtttt    13980

tatttttcaa gggagtattc agtacctaca aacccaagtc aggaagcctg ctagtggctt    14040

tggttctttc agaggctgct cgatgccttg tgtgtcagaa agaaagattc agcagttttg    14100

catcatggca aagaagcctg ttattttggg gctcagcccc tcattttata gaggatgaaa    14160

cagaggggga tgggaggtca caaagacaac tgccccggga gcaggtgtgg gggagacttg    14220

ccctgagggt ctagacgctc tgcaccaccg tcctgtctcc cttgctgaag accacacatg    14280

cccttctttg accagaccct gccacctgat aggccaggac ctggtaggcg ggtacccagg    14340

tttcatggat ggaaccacat ctccccaaaa gtggggaggt agctactggg atgcacgcct    14400

cccgccatgt gctataggag agcagctgaa gcaacagttg ggatcagatg tagtcacaat    14460

tgaatgcatc atcacattta tccctctaag tggctgggag agttgatatc ctcatcccta    14520

aggtacaaaa tgttccaatt tgatcagtgg ctttcaggag ctgagaaagg catgtgctct    14580

gaggcagagc tgttatgtcc cgcagagcct aaaaatgctc taagaacatg ctccctgcca    14640

aaattctcaa tggctgtgac aagggacaac gatcgaccaa tgggggtgga agcagacctc    14700

cgcagtccag gggccagagc taggacagag gggtcggaga aagagtcatt ttcccaacac    14760

tccagctctt ggccagtcct cacacagtcc cctcctgctt cctgctgaga gagatatcct    14820

cataggtctg ggtaaagtcc ttcagtcagc tttcattccc tgtcaccaac tttgtctctg    14880

ttctccctgc ccgtctcagg cagcactcct caggaaacct ctccaagagc cagcctcact    14940

gcagcgccca ctattgtccc tctgcctcaa gtgtcccatc catgccaggc cccaggcagg    15000

ctgcagcttt ccctcagggc cacaccaaag cacttgggct cagctgtgct gtccccctcc    15060

atcactgagc tcaggggcag caggggtggg gtgccaggag gcccattcac ccttctctgg    15120

ctctgtgttg gacccacctg cccagccact gctgcttaga acctacccgc tgggaaaatg    15180

aagccctccc ggaggggcca cctcaacctg agagcctcac ggatcacagt tgtccccact    15240

cagctctgcc agccctcaga gacccataga taaaagctga gcttggctcg cagagctggt    15300

tccatcttcc attcccagag ggttcaactt cctaccccaa ccacacaggg aacctcaagg    15360

ctgagccagt gtgggctgca gtgcagacca gcttcctgga cacgtcctgc cacctgaccc    15420

caggctggcc tcactgcccc tggcactcct gaccctatcc tcattcctcc tggcagtgcg    15480

tgttctgcca ttccgctttc ccttagctgt cctctcactg tactgtcagc ttctcctttt    15540

ccaggtgccc cccaggggct ttccacatga ccctgtcacc ccacagccca tccagcacca    15600

attccagctc tctgccaccc ttcaaaggag tgacagtgcc ctgcttcacc tcccactcac    15660

ccctcaaccc agagcaatct ggctccagtc ttgcctcctt ccccctaagt actctagtca    15720

cagttccaaa ttcctcctgg tcataaagcc aaatgaagct tcctggtcct cagcggactt    15780

gccacttcag cagtactgga ctctctcctc ccagaaacct gtttcccctt ggctcctgga    15840

gcccacactc tgctggaatc cttctgcctc tctggcctgt agcctggccc tctctcccaa    15900

cctgaggtcc attctctcct gctcctccac aagatgttgc tccttccatt acttcctccc    15960

tctcaaccaa agctccttca ttagctcttt atcttctggt ttcttcccct gggcagacga    16020

atggattcaa gagcctgtgg cccagcagcc cagcactcca ggatctcagc acttcagcat    16080

cccagtaccc tagcatctca ataccccagc accccagcac catagtattc cagcacccca    16140

ttgtccaagc atctcagcac tccagcatcc cagcacccca acactccagc agcccagaat    16200

ctcagcaccc tagcactgca gcatctcagg accccagcac ttcagcatcc cagcacacta    16260

gtactccagc atctcggcac cccagcacct aggcatccca acacccagca ccccagcact    16320

taagcatccc accactacag tatctcaaca ctccagcacc ccagcaccat agtgttccag    16380

caccccagca tcccaacacc ccagcactta agcatcccaa cacctcggca tcccaacacc    16440

ccagcactgc agcatctcag caccttagca tcccagtgcc ctagcatctc aatgctccag    16500

cacaccagta ctacagtatt ccagcacccc agcactccag catctcagca ctgcagcact    16560

gcagcactcc agcatcccaa aatcccagca tcccaacacc ccagcagacc agcagaccag    16620

catctcagca ccgcagcatc caaggactat cccagcatcc cagcaaccca gcacctcagc    16680

atcccaacac cccagcattt cagcatggca acaccccagt accccagcac ttcagcaccc    16740

cagtatccca gcatctcagc gacccagtat cacaaaacct cagcatccta gcaccccagc    16800

accccagcac cttagcacct tagcatccca gcatctcagc gcctcagcat cttgatattc    16860

tggctgaggt cagcgtggtg tatctagtca gggtcctaac tttcacttcg cagggaaatg    16920

ctgctggact gggtctcatg ttgggctgaa gctctctaga ccccttgaag acagcataaa    16980

agagcttgga gacgctgggt gtcccccatg gaagagttca ctctcatcct gctttgacaa    17040

cagccttctc tggggtccct cacgggcccc tctttcttac tgcaagtttg tctctgagaa    17100

gactgtgatg cagaagtcac tcagctgcct gtggctcctg aagagctgaa ggtggaggcc    17160

tgtaggcctc cctatgagag gcgcagaaaa aaccatgatt gctagtgggg aggtgctccc    17220

tctacaaccc actccataat ctgcccccgc ccagctctga ggccagcccc aggggaaaat    17280

gccagatccc cagggaggtg tgtgagacct caggggctcc ctcctccctt acagcaggct    17340

caggcccctg ggggcctcag ggccaaggtc tgtgggtaag ctactatctc tcacttgtcc    17400

tctagccaca aaagccaggg agatctggca atggacatga ggttctgaag aagcacatat    17460

gactggcttc ctaatgcgtg gttgttcagt gattcaataa acacgcatgg gccaggcatg    17520

gggaaataga caaacatgat ccccaacctc tcccagagtg aactgggagg gaggagtgtt    17580

catccctcag gattacacca gagaaacaaa ccagcaggag atatatatgg ttttgggggg    17640

tcaagaaaga ggaaaaacct ggcaaggcaa gtccaaaatc ataggacagg ctgtcaggaa    17700

gggcagcctg gaacctctca agcaggagct gatgctgcag tccacaggca gaatttcttc    17760

ttcctcgggg aaatctcagc tttgttctta aggcctttca actgattggc tgaggtctgc    17820

cccttccccc acattctcca ggataatctt ccttacttaa agtcaactat taatcacagc    17880

tacaaaatcc cttcacagct acacatagat cagtgtttga ttgacgaaca gcccctacag    17940

cctagccaag ttgacacata aaactaacca tcacaggggg acaaatgatg taaacacatc    18000

aacaaataaa acagtaacaa gttaaggtct atggaaaaaa cacagaaggg gcagagagaa    18060

agaaagcaag aaggagagtc ccagtttgct agggcttgtg ggaagtgggg agcagttctc    18120

tttagctagg atatttggga aaggcatatc tgaaggagtg atatttgagc ttagattaaa    18180

agatgggaag gagcaagcca tgcaaagagc taggatgttc caagcagaga cggaacagca    18240

agtgcaaatg tcaggaggaa tagaaggagg ctggtgggtg gggtccagtg agcaagagga    18300

gggcaggcag gagaggggat ggggaggtgg gcaggcccag accacccagg gccctggaga    18360

ctatcctgat ccaacaaggg aagccttgag tcacttcagt gtccatgtgg agaatggacc    18420

tcagactgaa tgagggaggc agtaaggagg gcctctacct ccagggcttc gccctgtgga    18480

ctgcgcatag acatctccaa ctcagaaagt ctgaaccaaa ctttccatag ttcccccaag    18540

tctgggcatc ctcctactca gtgaaaggca gccatcacac ctccctgccc tgctcccgga    18600

tgccccaaat cctcttggtc tccaagtcca gaacctgaga cttgtccttg atgtttgtct    18660

ttccctcacc ctttctgtat tctgggaaga tgggtttttt tcccccagat gaatctgtaa    18720

aacttctgtg atcacaataa aaattctggc agtattattt tctggaacat gacaaagtga    18780

ttcaaaatta tttatctgga agactacaaa acaagaatag ccaggaaatt tctaaaaaga    18840

aagaagaagg aggaggagaa agaaggagga ggaaaaggag gagaagaaga aaagaaaaag    18900

aaccaagaaa gggttctagc tctaccaaat attaaaacat atcatgaagc tatttaaaac    18960

aatatggttg tggatactga aaaagatgtg aataaagtgg aaggaaaata aatagaaatg    19020

cacatgggga ttgagactgt gaaaaaggca gcatctcaca tcagtgaggg atgttcaaca    19080

cctggtgttg ggaaaactgg ctagtcattt aaaccaaaca actgggtcct ctacctcact    19140

cctgacatta agatacattt agatgattca aagagtaaga cagaaaaaat aacacgtgaa    19200

aacactatca gaaaacaacg tgggccaggt gtggtgggtc acgcctgtaa tcccagcact    19260

ttgggaggcc gaggcagaca gatcacctga ggtggggagt tcaagaccag cctgaccaac    19320

atggtgaaat cctgtctcta ctaaaaatac aaaattagct gagcgtggtg gcgcatgcct    19380

gtaatcccag ctactcagga ggccgaggca ggagaatcac ttgaacctgg gaggcagagg    19440

ttgtggtgag ccgagatcac gccattgcac tccagcctgg gcaacaagag tgaaaatcca    19500

tctaaaaaaa aaaaaaaaag ccaaggtgga tatttttata gtatcagggt agatcaagct    19560

tctccaatca tgacatgaaa cccagaaacc ataaaagaaa agaatgataa aattgcccac    19620

gtaaagtaaa aagcttgcac acagaaaaac accatacagg ttacaagatg agcagcaaaa    19680

tcagagaaaa aacattgcaa ttcaggacac acagaggcta ttgttcctaa tatttaaaaa    19740

taaaagtagt ggattgtcta caaaaagatg aagacaagaa tttcagaaaa ccaaatactg    19800

catgttttca cttacaagtg gaagctaaac actgagtaca cgtgtacaca aagaatggaa    19860

ccataggcca ggcaccgtgg ctcacgcctg taatcccagt actttgcgag gccgaagcgg    19920

gcggatcacc tgaggtgagg agttcgagac catcctggcc aacatggtga aacccagtct    19980

ctactaaaaa tacaaaaatt agccgggcgt ggtggtgggt gcctgtaatc ccagctactc    20040

gggaggctgc ggcagtagaa tcgcttgaac cctggaggtg gaccttgcag tgagccgaga    20100

tcgcaccact gcactccagc ctgggcaaca gagtgagact ccatctcaaa aaaaaaaaaa    20160

aggaatagaa caatagacac tggggcctac ttgagggagg agggtgagga tcaaaaacct    20220

gcctatcagg tactatgctt attacctggg tggtgaaata atctgtacac caaaccccag    20280

tgacatgcaa tttaccgatg taacaaacct gcccatgtac ccgctgaacc taaaataaaa    20340

gttggaaaaa aatatagaaa ttttctttgt aatagccaaa aactgcaaac agcccaggtg    20400

tctattagta gaatgcataa acaaactcgg gcatgttcat acaatgtaaa actactcatc    20460

aataaaaagt gatacttctc agcaatgaaa agaaactagc tactgatacc agctacaaca    20520

tggatggatt tcaagtgctt tatgatgaga gcaagaagcc agacacaaaa gtgtctatat    20580

atatatacag tatatatacg tatatataca catatataca gtatatatat acatatacat    20640

gtatatatat actgtatata tactgtatat atatacacag tatatatata catatataca    20700

gtgtatatat actgtgtata tatacatgta tatatactgt gtatatatac atgtatatat    20760

actgtgtata tatacatgta tatatactgt gtatatatac atgtatatat atgtatactg    20820

tatatatact gtatatatat atacacatat atacagtata tatatacagt atatactgta    20880

tatatacagt atatacgtgt atatatacat atatacagta tatatgtaaa tatacatata    20940

tacagtatat atgtaaatat acatatatac atgtatatat atacactata tatatacata    21000

tatagtgtat atatacatat atacatgtat atatttacta tatgattcca tttatataaa    21060

gtgccaaaac agtcaaaaat aatctatgtg gaaaaaatca acaaagggat cccccgggct    21120

gcaggaattc gatggcgcgc cctttgggga gtcctaagag ggcagctggc aatggacacc    21180

tagcagtccc tttgagactt atttcagatg gagctgtaga aagatgccat ggctcacagt    21240

gcctccctgg gaagggggca gagggctgcc cagtgaggcc tcttgcgagc aggaaatcac    21300

cagagacaag gaaagaccag accccaggat gacctcagtt aggccttgcc cgactgtcct    21360

cagagtccca ttctctgtgt cctggttctt ttagaagatc atggacctcc aggtcatttc    21420

gtaaccggaa tctgcctgcg gggggttttg acaagctatg gtatagtgta tgtgggggta    21480

ctgacgaatt ggaagatcat ggagacccct tctcctcctc catcattggt ctgccacatc    21540

cctcccaggc gactcacagc agagagacct tggatgtatg tagggtgctt taaaactcca    21600

gctgagttac agtctctcct ttctgttttc accttaacct tccagggatg caaacccacg    21660

acaggtttag cagcagagtg gaggctggcc atgaatctca gagaaagtgc tcactggaaa    21720

ggctggttta gcccaggcct gatgtggagg cactgagctg gacgttctag cggggttgac    21780

acccaacagt ttacataggg ggaggccacc cctcctgagc agtctcggtg acttgaagag    21840

gaagccgctt cttctgtacc aacacagaag ctccagcgaa cccccagaat gctggcagtg    21900

tgggtgctat gtaaaagtat ttacatagct ttgtagagtg agccaagccc agtctgtttg    21960

ggatgactct tcacagtgcc tcgaatctgt cacacgtctt agtaagcaga gtcacagagt    22020

ttctgtcaca tcatcctcct gcctacaggg aagtaggcca tgtccctgcc ccctactctg    22080

agcccagctg tgggagccag ccctgcccaa tgggctctct ctgattggct tctcactcac    22140

ttctaaactc cagtgagcaa cttctctcgg ctcgttcaat tggcgtgaag gtctgtgtct    22200

tgcagagaag gttcttcaca actgggataa aggtctcgct gctcaagtgt agcccagtag    22260

aactgccaag ccccttcccc tcctctccct agactcttgg atgcaagaag aatccaggca    22320

gctccaaggg tgattgtgtc caacctagaa tgtcttgaaa aagacattaa ggggactaga    22380

gaagacaggg gatccaacgg ttctctgcag cccagcctga ctgacatgta actcttctgg    22440

ttctcaccag ccagctggac ctgcttagta ttctttctgc ctcagtttcc cagcctgtac    22500

ccagggctgt catagttcca tttcaggcag tagtaatgaa tgagctgaca taaaacattt    22560

agagcagggg tcagtatgta tatagagtga ttattctata tcaggcattg cctcctcgga    22620

atgaagctta caatcacccc tccctctgca gttcatcttg gggtggccag aggatccagc    22680

agacacctag tggggtaaca caccccagcc aactcggctg ttgcagactt tgtctagaag    22740

tttcacgtct cagagctgaa ttcccttctc atgacctttg gccgtgggag tgacacctca    22800

cagctgtggt gttttgacaa ccagcagcca ctggcacaca aaatgtgcag ccagcagcat    22860

atgaagtcca agaggcgtcc cggccagccc tgtccttgac ccccacctga caattaaggc    22920

aagagcctat agtttgcatc agcaacagtc acggtcaaag tttagtcaat caaacgttgt    22980

gtaaggactc aactatggct gacacggggg cctgaggcct cccaacattc attaacaaca    23040

gcaagttcaa tcattatctc cccaaagttt attgtgttag gtcagttcca aaccgtgctg    23100

accatggcta tgatccaaag gccggcccct tacgtcagag gcgagcctcc aggtccagct    23160

gaggggcagg gctgtcctcc cttctgtata ctatttaaag cgaggagggc tagctaccaa    23220

gcacggttgg ccttccctct gggaacacac ccttggccaa caggggaaat ccggcgagac    23280

gctctgagat cctgcgagaa ggaggtgcgt cctgctgcct gccccggcac tctggctccc    23340

cagctcaagg ttcaggcctt gccccaggcc gggcctctgg gtacctgagg tcttctcccg    23400

ctctgtgccc ttctcatggc gtcacgcata gggttgcgca tgcagctcat gcgggagcag    23460

gcgcagcagg aggagcagcg ggagcgcatg cagcaacagg ctgtcatgca ttacatgcag    23520

cagcagcagc agcagcaaca gcagcagctc ggagggccgc ccaccccggc catcaatacc    23580

cccgtccact tccagtcgcc accacctgtg cctggggagg tgttgaaggt gcagtcctac    23640

ctggagaatc ccacatccta ccatctgcag cagtcgcagc atcagaaggt gcgggagtac    23700

ctgtccgaga cctatgggaa caagtttgct gcccacatca gcccagccca gggctctccg    23760

aaacccccac cagccgcctc cccaggggtg cgagctggac acgtgctgtc ctcctccgct    23820

ggcaacagtg ctcccaatag ccccatggcc atgctgcaca ttggctccaa ccctgagagg    23880

gagttggatg atgtcattga caacattatg cgtctggacg atgtccttgg ctacatcaat    23940

cctgaaatgc agatgcccaa cacgctaccc ctgtccagca gccacctgaa tgtgtacagc    24000

agcgaccccc aggtcacagc ctccctggtg ggcgtcacca gcagctcctg ccctgcggac    24060

ctgacccaga agcgagagct cacagatgct gagagcaggg ccctggccaa ggagcggcag    24120

aagaaagaca atcacaactt aattgaaagg agacgaaggt tcaacatcaa tgaccgcatc    24180

aaggagttgg gaatgctgat ccccaaggcc aatgacctgg acgtgcgctg gaacaagggc    24240

accatcctca aggcctctgt ggattacatc cggaggatgc agaaggacct gcaaaagtcc    24300

agggagctgg agaaccactc tcgccgcctg gagatgacca acaagcagct ctggctccgt    24360

atccaggagc tggagatgca ggctcgagtg cacggcctcc ctaccacctc cccgtccggc    24420

atgaacatgg ctgagctggc ccagcaggtg gtgaagcagg agctgcctag cgaagagggc    24480

ccaggggagg ccctgatgct gggggctgag gtccctgacc ctgagccact gccagctctg    24540

cccccgcaag ccccgctgcc cctgcccacc cagccaccat ccccattcca tcacctggac    24600

ttcagccaca gcctgagctt tgggggcagg gaggacgagg gtcccccggg ctaccccgaa    24660

cccctggcgc cggggcatgg ctccccattc cccagcctgt ccaagaagga tctggacctc    24720

atgctcctgg acgactcact gctaccgctg gcctctgatc cacttctgtc caccatgtcc    24780

cccgaggcct ccaaggccag cagccgccgg agcagcttca gcatggagga gggcgatgtg    24840

ctgtgagaat tccgcgaatc aacctctgga ttacaaaatt tctgaaagat tgactggtat    24900

tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca    24960

tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc    25020

tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc    25080

tgacgcaacc cccactggtt ggggcattgc caccacctgt caactccttt ccgggactta    25140

cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg    25200

gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga agctgacgtc    25260

ctttccatgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta    25320

cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg    25380

gcctcttccg cgtcttcgcc ttcgccctca gacgactcgg atctcccttt gggccgcctc    25440

cccgcggcgc gccgacgcgc atgctcctct agactcgagg aattcggtac cccgggttcg    25500

aaatcgataa gcttgatatc gaattcctgc aggctcagag gcacacagga gtttctgggc    25560

tcaccctgcc cccttccaac ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc    25620

tctgaagtcc acactgaaca aacttcagcc tactcatgtc cctaaaatgg gcaaacattg    25680

caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag ctggggcaga    25740

ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc ttggaatttc    25800

ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg gtccgggttc    25860

aaaaccactt gctgggtggg gagtcgtcag taagtggcta tgccccgacc ccgaagcctg    25920

tttccccatc tgtacaatgg aaatgataaa gacgcccatc tgatagggtt tttgtggcaa    25980

ataaacattt ggtttttttg ttttgttttg ttttgttttt tgagatggag gtttgctctg    26040

tcgcccaggc tggagtgcag tgacacaatc tcatctcacc acaaccttcc cctgcctcag    26100

cctcccaagt agctgggatt acaagcatgt gccaccacac ctggctaatt ttctattttt    26160

agtagagacg ggtttctcca tgttggtcag cctcagcctc ccaagtaact gggattacag    26220

gcctgtgcca ccacacccgg ctaatttttt ctatttttga cagggacggg gtttcaccat    26280

gttggtcagg ctggtctaga actcctgacc tcaaatgatc cacccaccta ggcctcccaa    26340

agtgcacaga ttacaggcgt gggccaccgc acctggccaa atttttaatt tttttctaga    26400

gatagggtct tactgtgttg cccaggctgg tgtcaaactc ctgggctcaa gcagatcctc    26460

ctgcctcagc ttcccaaagt ggtgggatta taggtgtgag ccactgcgcc cagtcagtag    26520

ccccctcttt gcccctcact gagccctact ggatgttctt ggttgtgtga cagtttcccc    26580

atctattaaa cagaaacccc tatagcagag gggaggatga ggttggaaaa tcaggagcat    26640

tgttattcta ttcttgtggg atcggggaag cagacatctg ggtggatgtt tggggaatgc    26700

tgggctcagt tgaggaagta ggggggcccc tggggcttac agggactgga agctctgagc    26760

tggccagagg gatgttgcaa tcctgccagg gtcttgtcta tgctgtccct ttcacaacca    26820

tccccctacc gccaggctga cacgtggttg tgggggcaca aggccagccg aactagagtc    26880

tgaggctggg ctgaggacac cctccccatc agctgccagg gtcactggcg gtcaaaggca    26940

gctggtgggg aaggaattgg actccagccc tgggggacgg atgtggtgat ggtgggaagc    27000

aggcttggtg ccaggagggg catcagaggg tgaataagag cagatagagt gtttggggga    27060

ggtagccagc caaagggggt gaggcccggt ggaagggaag aaggggcata cactcagagc    27120

tttgcagctg aaggttttaa ttttttgaga tggggtctca ctctgtctca ccaggctgga    27180

gtgcagtggc gcaatcacag ctcactgcag cccgggggat ccggagagct cgtcgacggc    27240

gcgccaattc ctgcagcccg ggtggcatcc ctgtgacccc tccccagtgc ctctcctggc    27300

cctggaagtt gccactccag tgcccaccag ccttgtccta ataaaattaa gttgcatcat    27360

tttgtctgac taggtgtcct tctataatat tatggggtgg aggggggtgg tatggagcaa    27420

ggggcaagtt gggaagacaa cctgtagggc ctgcggggtc tattgggaac caagctggag    27480

tgcagtggca caatcttggc tcactgcaat ctccgcctcc tgggttcaag cgattctcct    27540

gcctcagcct cccgagttgt tgggattcca ggcatgcatg accaggctca gctaattttt    27600

gtttttttgg tagagacggg gtttcaccat attggccagg ctggtctcca actcctaatc    27660

tcaggtgatc tacccacctt ggcctcccaa attgctggga ttacaggcgt gaaccactgc    27720

tcccttccct gtccttctga ttttaaaata actataccag caggaggacg tccagacaca    27780

gcataggcta cctggccatg cccaaccggt gggacatttg agttgcttgc ttggcactgt    27840

cctctcatgc gttgggtcca ctcagtagat gcctggcgcg cctaccagta aaaaagaaaa    27900

cctattaaaa aaacaccact cgacacggca ccagctcaat cagtcacagt gtaaaaaagg    27960

gccaagtgca gagcgagtat atataggact aaaaaatgac gtaacggtta aagtccacaa    28020

aaaacaccca gaaaaccgca cgcgaaccta cgcccagaaa cgaaagccaa aaaacccaca    28080

acttcctcaa atcgtcactt ccgttttccc acgttacgtc acttcccatt ttaagaaaac    28140

tacaattccc aacacataca agttactccg ccctaaaacc tacgtcaccc gccccgttcc    28200

cacgccccgc gccacgtcac aaactccacc ccctcattat catattggct tcaatccaaa    28260

ataaggtata ttattgatga tgttt                                          28285


<210>  9
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


