                         SEQUENCE LISTING

<110>  Emergent Biosolutions Product Development Seattle, LLC.
       Natarajan, Sateesh K
       Tan, Philip H
       McMahan, Catherine J
 
<120>  CD3 Binding Polypetides

<130>  2479.113PC03/EJH/BNC

<140>  To be assigned
<141>  Herewith

<150>  US 61/799,849
<151>  2013-03-15

<150>  US 61/718,635
<151>  2012-10-25

<150>  US 61/636,557
<151>  2012-04-20

<160>  255   

<170>  PatentIn version 3.5

<210>  1
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Signal peptide

<400>  1
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcg       60

cgagga                                                                  66


<210>  2
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Signal peptide

<400>  2

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  3
<211>  1434
<212>  DNA
<213>  Artificial

<220>
<223>  DRA209 (H2 L1 with IgG4 AA ADCC-CDC null Fc)

<400>  3
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      420

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      480

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc      540

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      600

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      660

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag      720

ctacaaatta cacgacgaac tgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc agctccgtca gtcttcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccaggaa      900

gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagtt caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaacgg caaggcatac gcctgcgctg tctccaacaa aggcctcccg     1080

tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagagcc acaggtgtac     1140

accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1200

aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcagg     1320

ctaaccgtgg acaagagccg gtggcaggag gggaatgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg taaa           1434


<210>  4
<211>  478
<212>  PRT
<213>  Artificial

<220>
<223>  DRA209 (H3 L1 with IgG4 AA ADCC-CDC null Fc)

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Arg Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys 
            340                 345                 350         


Ala Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  5
<211>  1434
<212>  DNA
<213>  Artificial

<220>
<223>  DRA219 (H3 L1 IgG4 AA ADCC-CDC null Fc)

<400>  5
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      420

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      480

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc      540

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      600

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      660

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag      720

ctacaaatta catcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc agctccgtca gtcttcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccaggaa      900

gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagtt caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaacgg caaggcatac gcctgcgctg tctccaacaa aggcctcccg     1080

tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagagcc acaggtgtac     1140

accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1200

aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcagg     1320

ctaaccgtgg acaagagccg gtggcaggag gggaatgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg taaa           1434


<210>  6
<211>  478
<212>  PRT
<213>  Artificial

<220>
<223>  DRA219 (H3 L1 IgG4 AA ADCC-CDC null Fc)

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys 
            340                 345                 350         


Ala Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  7
<211>  1434
<212>  DNA
<213>  Artificial

<220>
<223>  DRA222 (H4 L1 with IgG4 AA ADCC-CDC null Fc)

<400>  7
caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      420

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      480

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc      540

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      600

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      660

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag      720

ctacaaatta catcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc agctccgtca gtcttcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccaggaa      900

gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagtt caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaacgg caaggcatac gcctgcgctg tctccaacaa aggcctcccg     1080

tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagagcc acaggtgtac     1140

accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1200

aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcagg     1320

ctaaccgtgg acaagagccg gtggcaggag gggaatgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg taaa           1434


<210>  8
<211>  478
<212>  PRT
<213>  Artificial

<220>
<223>  DRA222 (H4 L1 with IgG4 AA ADCC-CDC null Fc)

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys 
            340                 345                 350         


Ala Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  9
<211>  1434
<212>  DNA
<213>  Artificial

<220>
<223>  DRA221 (H4 L3 with IgG4 AA ADCC-CDC null Fc)

<400>  9
caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      420

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      480

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc      540

cccaaactcc tcatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      600

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      660

gccacttatt actgccagca gtggagtcgt aacccaccca ctttcggcgg agggaccaag      720

gtggagatca aatcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc agctccgtca gtcttcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccaggaa      900

gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagtt caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaacgg caaggcatac gcctgcgctg tctccaacaa aggcctcccg     1080

tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagagcc acaggtgtac     1140

accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1200

aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcagg     1320

ctaaccgtgg acaagagccg gtggcaggag gggaatgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg taaa           1434


<210>  10
<211>  478
<212>  PRT
<213>  Artificial

<220>
<223>  DRA221 (H4 L3 with IgG4 AA ADCC-CDC null Fc)

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys 
            340                 345                 350         


Ala Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  11
<211>  1434
<212>  DNA
<213>  Artificial

<220>
<223>  DRA223 (H3 L3 with IgG4 AA ADCC-CDC null Fc)

<400>  11
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      420

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      480

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc      540

cccaaactcc tcatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      600

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      660

gccacttatt actgccagca gtggagtcgt aacccaccca ctttcggcgg agggaccaag      720

gtggagatca aatcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc agctccgtca gtcttcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccaggaa      900

gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagtt caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaacgg caaggcatac gcctgcgctg tctccaacaa aggcctcccg     1080

tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagagcc acaggtgtac     1140

accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1200

aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcagg     1320

ctaaccgtgg acaagagccg gtggcaggag gggaatgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg taaa           1434


<210>  12
<211>  478
<212>  PRT
<213>  Artificial

<220>
<223>  DRA223 (H3 L3 with IgG4 AA ADCC-CDC null Fc)

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys 
            340                 345                 350         


Ala Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  13
<211>  1443
<212>  DNA
<213>  Artificial

<220>
<223>  DRA224 (H5 L4 with IgG4 AA ADCC-CDC null Fc)

<400>  13
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agatctacga tgcactgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagaccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc      360

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga      420

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg ggaaagagcc      480

accctctcct gcagtgccag ctcaagtgta agttacatga actggtacca acagaaacct      540

ggccaggctc ccaggctcct catctatgac tcatccaaac tggcttctgg catcccagcc      600

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      660

gaagattttg cagtttatta ctgtcagcag tggagtcgta acccacccac tttcggcgga      720

gggaccaagg tggagatcaa atcctcgagc gagcccaaat cttctgacaa aactcacaca      780

tgcccaccgt gcccagcacc tgaagccgca gctccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg      900

agccaggaag accccgaggt ccagttcaac tggtacgtgg atggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagttc aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaacggc aaggcatacg cctgcgctgt ctccaacaaa     1080

ggcctcccgt cctccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagagcca     1140

caggtgtaca ccctgccccc atcccaggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaggc taaccgtgga caagagccgg tggcaggagg ggaatgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acacagaaga gcctctccct gtctccgggt     1440

aaa                                                                   1443


<210>  14
<211>  481
<212>  PRT
<213>  Artificial

<220>
<223>  DRA224 (H5 L4 with IgG4 AA ADCC-CDC null Fc)

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  15
<211>  1443
<212>  DNA
<213>  Artificial

<220>
<223>  DRA225 (H6 L4 with IgG4 AA ADCC-CDC null Fc)

<400>  15
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agatctacga tgcactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggaccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc      360

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga      420

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg ggaaagagcc      480

accctctcct gcagtgccag ctcaagtgta agttacatga actggtacca acagaaacct      540

ggccaggctc ccaggctcct catctatgac tcatccaaac tggcttctgg catcccagcc      600

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      660

gaagattttg cagtttatta ctgtcagcag tggagtcgta acccacccac tttcggcgga      720

gggaccaagg tggagatcaa atcctcgagc gagcccaaat cttctgacaa aactcacaca      780

tgcccaccgt gcccagcacc tgaagccgca gctccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg      900

agccaggaag accccgaggt ccagttcaac tggtacgtgg atggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagttc aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaacggc aaggcatacg cctgcgctgt ctccaacaaa     1080

ggcctcccgt cctccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagagcca     1140

caggtgtaca ccctgccccc atcccaggag gagatgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaggc taaccgtgga caagagccgg tggcaggagg ggaatgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acacagaaga gcctctccct gtctccgggt     1440

aaa                                                                   1443


<210>  16
<211>  481
<212>  PRT
<213>  Artificial

<220>
<223>  DRA225 (H6 L4 with IgG4 AA ADCC-CDC null Fc)

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
    290                 295                 300                 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  17
<211>  1434
<212>  DNA
<213>  Artificial

<220>
<223>  DRA233 (H3 L1 with IgG4 AA N297A mutations - different Fc tail 
       than the top constructs)

<400>  17
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      420

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      480

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc      540

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      600

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      660

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag      720

ctacaaatta catcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc agctccgtca gtcttcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccaggaa      900

gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagtt cgccagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa aggcctcccg     1080

tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagagcc acaggtgtac     1140

accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1200

aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcagg     1320

ctaaccgtgg acaagagccg gtggcaggag gggaatgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg taaa           1434


<210>  18
<211>  478
<212>  PRT
<213>  Artificial

<220>
<223>  DRA233 (H3 L1 with IgG4 AA N297A mutations - different Fc tail 
       than the top constructs)

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  19
<211>  1434
<212>  DNA
<213>  Artificial

<220>
<223>  DRA234 (H4 L1 with IgG4 AA N297A mutations - same Fc tails as 
       DRA233)

<400>  19
caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      420

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      480

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc gggcaaggcc      540

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      600

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      660

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag      720

ctacaaatta catcctcgag cgagcccaaa tcttctgaca aaactcacac atgcccaccg      780

tgcccagcac ctgaagccgc agctccgtca gtcttcctct tccccccaaa acccaaggac      840

accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccaggaa      900

gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg aggtgcataa tgccaagaca      960

aagccgcggg aggagcagtt cgccagcacg taccgtgtgg tcagcgtcct caccgtcctg     1020

caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa aggcctcccg     1080

tcctccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagagcc acaggtgtac     1140

accctgcccc catcccagga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1200

aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1260

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcagg     1320

ctaaccgtgg acaagagccg gtggcaggag gggaatgtct tctcatgctc cgtgatgcat     1380

gaggctctgc acaaccacta cacacagaag agcctctccc tgtctccggg taaa           1434


<210>  20
<211>  478
<212>  PRT
<213>  Artificial

<220>
<223>  DRA234 (H4 L1 with IgG4 AA N297A mutations - same Fc tails as 
       DRA233)

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  21
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  H1 chain

<400>  21
caggtccagc tggtgcagtc tggggctgaa gtgaagaagc ctggggcctc agtgaaggtg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaaacaggcc      120

cctggacagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacaa ggccacattg actgcagaca aatcctccag tacagcctac      240

atgcaactga gtagcctgag gtctgaggac accgcagtct attactgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactctggt cactgtctct      360

agc                                                                    363


<210>  22
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  H1 chain

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  H2 chain

<400>  23
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacaa ggccacattg actgcagaca aatccaagaa cacagcctac      240

atggagctga gtagcctgag gtctgaggac accgcagtct attactgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactctggt cactgtctct      360

agc                                                                    363


<210>  24
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  H2 chain

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  25
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  H3 chain

<400>  25
caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agc                                                                    363


<210>  26
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  H3 chain

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  H4 chain

<400>  27
caggtccagc tggtggagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg       60

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      120

cctggacaag gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      240

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      360

agc                                                                    363


<210>  28
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  H4 chain

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  H5 chain

<400>  29
caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agatctacga tgcactgggt gcgccaggcc      120

cccggacaaa ggcttgagtg gatgggatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggacag agtcaccatt accagggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagaccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  30
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  H5 chain

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  H6 chain

<400>  31
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agatctacga tgcactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatac attaatccta gcagtgctta tactaattac      180

aatcagaaat tcaaggaccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaccccaa      300

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  32
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  H6 chain

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  33
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  L1 chain

<400>  33
gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg       60

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagaag      120

ccgggcaagg cccccaaaag atggatttat gactcatcca aactggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc gactataccc tcacaatcag cagcctgcag      240

cccgaagatt tcgccactta ttactgccag cagtggagtc gtaacccacc cacgttcgga      300

ggggggacca agctacaaat taca                                             324


<210>  34
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  L1 chain

<400>  34

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        35                  40                  45              


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
            100                 105             


<210>  35
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  L2 chain

<400>  35
gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg       60

gtcaccatca cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagacc      120

cccggcaagg cccccaaaag atggatttat gactcatcca aactggcttc tggagtccct      180

agccgcttca gtggcagtgg gtctgggacc gacttcaccc tcacaatcag cagcctgcag      240

cccgaagata tcgccactta ttactgccag cagtggagtc gtaacccacc cacgttcgga      300

caggggacca agctacaaat taca                                             324


<210>  36
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  L2 chain

<400>  36

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp 
        35                  40                  45              


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
            100                 105             


<210>  37
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  L3 chain

<400>  37
gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg       60

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagaag      120

ccgggcaagg cccccaaact cctcatttat gactcatcca aactggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc gactataccc tcacaatcag cagcctgcag      240

cccgaagatt tcgccactta ttactgccag cagtggagtc gtaacccacc cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  38
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  L3 chain

<400>  38

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  39
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  L4 chain

<400>  39
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgccagctc aagtgtaagt tacatgaact ggtaccaaca gaaacctggc      120

caggctccca ggctcctcat ctatgactca tccaaactgg cttctggcat cccagccagg      180

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tcagcagtgg agtcgtaacc cacccacttt cggcggaggg      300

accaaggtgg agatcaaa                                                    318


<210>  40
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  L4 chain

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  41
<211>  244
<212>  PRT
<213>  Artificial

<220>
<223>  DRA209 binding domains

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr 
                


<210>  42
<211>  247
<212>  PRT
<213>  Artificial

<220>
<223>  DRA209 plus junction sequence

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Arg Arg Thr 
                245         


<210>  43
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  IGHV1-69*1

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  44
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  IGHV3-30*01

<400>  44

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  45
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  CRIS7 VH

<400>  45

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr 
        115 


<210>  46
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  CRIS7 VL

<400>  46

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Phe Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  47
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  DRA161 VH

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  48
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  DRA161 VL

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  49
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CRIS7 VH CDR1

<400>  49

Arg Ser Thr Met His 
1               5   


<210>  50
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CRIS7 VH CDR2

<400>  50

Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  51
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CRIS7 VHCDR3

<400>  51

Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
1               5                   10      


<210>  52
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  CRIS7 VL CDR1

<400>  52

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  53
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CRIS7 VL CDR2

<400>  53

Asp Ser Ser Lys Leu Ala Ser 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CRIS7 VL CDR3

<400>  54

Gln Gln Trp Ser Arg Asn Pro Pro Thr 
1               5                   


<210>  55
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  DRA161 modified Fc domain

<400>  55

Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210>  56
<211>  2289
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized TSC249 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv)

<400>  56
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

gagtctgggg gcggagtggt gcagcctggg cggtcactga ggctgtcctg caaggcttct     1620

ggctacacct ttactagatc tacgatgcac tgggtaaggc aggcccctgg acaaggtctg     1680

gaatggattg gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacaggttca caatcagcgc agacaaatcc aagagcacag ccttcctgca gatggacagc     1800

ctgaggcccg aggacaccgg cgtctatttc tgtgcacggc cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaagggact cccgtcactg tctctagcgg tggcggaggg     1920

tctgggggtg gcggatccgg aggtggtggc tctgcacaag acatccagat gacccagtct     1980

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     2040

agtgtaagtt acatgaactg gtaccagcag aagccgggca aggcccccaa aagatggatt     2100

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     2160

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     2220

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacatcc     2280

tccagctaa                                                             2289


<210>  57
<211>  742
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized TSC249 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFV)

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
            500                 505                 510         


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu 
                565                 570                 575     


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                645                 650                 655     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            660                 665                 670         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        675                 680                 685             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    690                 695                 700                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
705                 710                 715                 720 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                725                 730                 735     


Gln Ile Thr Ser Ser Ser 
            740         


<210>  58
<211>  2268
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized TSC250 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H81 linker)

<400>  58
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtgaagttca aattcccttg     1500

accgaaagtt acagcccgaa ttctcaggtc cagctggtgg agtctggggg cggagtggtg     1560

cagcctgggc ggtcactgag gctgtcctgc aaggcttctg gctacacctt tactagatct     1620

acgatgcact gggtaaggca ggcccctgga caaggtctgg aatggattgg atacattaat     1680

cctagcagtg cttatactaa ttacaatcag aaattcaagg acaggttcac aatcagcgca     1740

gacaaatcca agagcacagc cttcctgcag atggacagcc tgaggcccga ggacaccggc     1800

gtctatttct gtgcacggcc ccaagtccac tatgattaca acgggtttcc ttactggggc     1860

caagggactc ccgtcactgt ctctagcggt ggcggagggt ctgggggtgg cggatccgga     1920

ggtggtggct ctgcacaaga catccagatg acccagtctc caagcagcct gtctgcaagc     1980

gtgggggaca gggtcaccat gacctgcagt gccagctcaa gtgtaagtta catgaactgg     2040

taccagcaga agccgggcaa ggcccccaaa agatggattt atgactcatc caaactggct     2100

tctggagtcc ctgctcgctt cagtggcagt gggtctggga ccgactatac cctcacaatc     2160

agcagcctgc agcccgaaga tttcgccact tattactgcc agcagtggag tcgtaaccca     2220

cccacgttcg gaggggggac caagctacaa attacatcct ccagctaa                  2268


<210>  59
<211>  1477
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized TSC250 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H81 linker)

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
            500                 505                 510         


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu 
                565                 570                 575     


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                645                 650                 655     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            660                 665                 670         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        675                 680                 685             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    690                 695                 700                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
705                 710                 715                 720 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                725                 730                 735     


Gln Ile Thr Ser Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ala 
            740                 745                 750         


Met Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        755                 760                 765             


Lys Ser Ile Ser Lys Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys 
    770                 775                 780                 


Val Pro Lys Leu Arg Ile His Ser Gly Ser Thr Leu Gln Ser Gly Val 
785                 790                 795                 800 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
                805                 810                 815     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            820                 825                 830         


His Ile Glu Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        835                 840                 845             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    850                 855                 860                 


Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
865                 870                 875                 880 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
                885                 890                 895     


Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
            900                 905                 910         


Met Gly Tyr Phe Asn Pro Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys 
        915                 920                 925             


Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala 
    930                 935                 940                 


Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr 
945                 950                 955                 960 


Cys Ala Arg Ser Asp Gly Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln 
                965                 970                 975     


Gly Thr Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
            980                 985                 990         


Thr His Thr Cys Pro Pro Cys Pro  Ala Pro Glu Ala Ala  Gly Ala Pro 
        995                 1000                 1005             


Ser Val  Phe Leu Phe Pro Pro  Lys Pro Lys Asp Thr  Leu Met Ile 
    1010                 1015                 1020             


Ser Arg  Thr Pro Glu Val Thr  Cys Val Val Val Asp  Val Ser His 
    1025                 1030                 1035             


Glu Asp  Pro Glu Val Lys Phe  Asn Trp Tyr Val Asp  Gly Val Glu 
    1040                 1045                 1050             


Val His  Asn Ala Lys Thr Lys  Pro Arg Glu Glu Gln  Tyr Asn Ser 
    1055                 1060                 1065             


Thr Tyr  Arg Val Val Ser Val  Leu Thr Val Leu His  Gln Asp Trp 
    1070                 1075                 1080             


Leu Asn  Gly Lys Ala Tyr Ala  Cys Ala Val Ser Asn  Lys Ala Leu 
    1085                 1090                 1095             


Pro Ala  Pro Ile Glu Lys Thr  Ile Ser Lys Ala Lys  Gly Gln Pro 
    1100                 1105                 1110             


Arg Glu  Pro Gln Val Tyr Thr  Leu Pro Pro Ser Arg  Asp Glu Leu 
    1115                 1120                 1125             


Thr Lys  Asn Gln Val Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr 
    1130                 1135                 1140             


Pro Ser  Asp Ile Ala Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu 
    1145                 1150                 1155             


Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser 
    1160                 1165                 1170             


Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln 
    1175                 1180                 1185             


Gln Gly  Asn Val Phe Ser Cys  Ser Val Met His Glu  Ala Leu His 
    1190                 1195                 1200             


Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu Ser Pro  Gly Glu Val 
    1205                 1210                 1215             


Gln Ile  Pro Leu Thr Glu Ser  Tyr Ser Pro Asn Ser  Gln Val Gln 
    1220                 1225                 1230             


Leu Val  Glu Ser Gly Gly Gly  Val Val Gln Pro Gly  Arg Ser Leu 
    1235                 1240                 1245             


Arg Leu  Ser Cys Lys Ala Ser  Gly Tyr Thr Phe Thr  Arg Ser Thr 
    1250                 1255                 1260             


Met His  Trp Val Arg Gln Ala  Pro Gly Gln Gly Leu  Glu Trp Ile 
    1265                 1270                 1275             


Gly Tyr  Ile Asn Pro Ser Ser  Ala Tyr Thr Asn Tyr  Asn Gln Lys 
    1280                 1285                 1290             


Phe Lys  Asp Arg Phe Thr Ile  Ser Ala Asp Lys Ser  Lys Ser Thr 
    1295                 1300                 1305             


Ala Phe  Leu Gln Met Asp Ser  Leu Arg Pro Glu Asp  Thr Gly Val 
    1310                 1315                 1320             


Tyr Phe  Cys Ala Arg Pro Gln  Val His Tyr Asp Tyr  Asn Gly Phe 
    1325                 1330                 1335             


Pro Tyr  Trp Gly Gln Gly Thr  Pro Val Thr Val Ser  Ser Gly Gly 
    1340                 1345                 1350             


Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Ala Gln 
    1355                 1360                 1365             


Asp Ile  Gln Met Thr Gln Ser  Pro Ser Ser Leu Ser  Ala Ser Val 
    1370                 1375                 1380             


Gly Asp  Arg Val Thr Met Thr  Cys Ser Ala Ser Ser  Ser Val Ser 
    1385                 1390                 1395             


Tyr Met  Asn Trp Tyr Gln Gln  Lys Pro Gly Lys Ala  Pro Lys Arg 
    1400                 1405                 1410             


Trp Ile  Tyr Asp Ser Ser Lys  Leu Ala Ser Gly Val  Pro Ala Arg 
    1415                 1420                 1425             


Phe Ser  Gly Ser Gly Ser Gly  Thr Asp Tyr Thr Leu  Thr Ile Ser 
    1430                 1435                 1440             


Ser Leu  Gln Pro Glu Asp Phe  Ala Thr Tyr Tyr Cys  Gln Gln Trp 
    1445                 1450                 1455             


Ser Arg  Asn Pro Pro Thr Phe  Gly Gly Gly Thr Lys  Leu Gln Ile 
    1460                 1465                 1470             


Thr Ser  Ser Ser 
    1475         


<210>  60
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized TSC251 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H83 linker)

<400>  60
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttcttccct gaatacagga     1500

actcagatgg caggtcattc tccgaattct caggtccagc tggtggagtc tgggggcgga     1560

gtggtgcagc ctgggcggtc actgaggctg tcctgcaagg cttctggcta cacctttact     1620

agatctacga tgcactgggt aaggcaggcc cctggacaag gtctggaatg gattggatac     1680

attaatccta gcagtgctta tactaattac aatcagaaat tcaaggacag gttcacaatc     1740

agcgcagaca aatccaagag cacagccttc ctgcagatgg acagcctgag gcccgaggac     1800

accggcgtct atttctgtgc acggccccaa gtccactatg attacaacgg gtttccttac     1860

tggggccaag ggactcccgt cactgtctct agcggtggcg gagggtctgg gggtggcgga     1920

tccggaggtg gtggctctgc acaagacatc cagatgaccc agtctccaag cagcctgtct     1980

gcaagcgtgg gggacagggt caccatgacc tgcagtgcca gctcaagtgt aagttacatg     2040

aactggtacc agcagaagcc gggcaaggcc cccaaaagat ggatttatga ctcatccaaa     2100

ctggcttctg gagtccctgc tcgcttcagt ggcagtgggt ctgggaccga ctataccctc     2160

acaatcagca gcctgcagcc cgaagatttc gccacttatt actgccagca gtggagtcgt     2220

aacccaccca cgttcggagg ggggaccaag ctacaaatta catcctccag ctaa           2274


<210>  61
<211>  737
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized TSC251 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H83 linker)

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Leu Asn Thr Gly 
465                 470                 475                 480 


Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Glu 
                485                 490                 495     


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
            500                 505                 510         


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg 
        515                 520                 525             


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
    530                 535                 540                 


Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile 
545                 550                 555                 560 


Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu 
                565                 570                 575     


Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His 
            580                 585                 590         


Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr 
        595                 600                 605             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
625                 630                 635                 640 


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
                645                 650                 655     


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            660                 665                 670         


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg 
        675                 680                 685             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
    690                 695                 700                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
705                 710                 715                 720 


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser 
                725                 730                 735     


Ser 
    


<210>  62
<211>  2286
<212>  DNA
<213>  Artificial

<220>
<223>  Huamnized TSC252 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H91 linker)

<400>  62
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaactcatt agcaaaccaa     1500

gaagttcaaa ttcccttgac cgaaagttac agcccgaatt ctcaggtcca gctggtggag     1560

tctgggggcg gagtggtgca gcctgggcgg tcactgaggc tgtcctgcaa ggcttctggc     1620

tacaccttta ctagatctac gatgcactgg gtaaggcagg cccctggaca aggtctggaa     1680

tggattggat acattaatcc tagcagtgct tatactaatt acaatcagaa attcaaggac     1740

aggttcacaa tcagcgcaga caaatccaag agcacagcct tcctgcagat ggacagcctg     1800

aggcccgagg acaccggcgt ctatttctgt gcacggcccc aagtccacta tgattacaac     1860

gggtttcctt actggggcca agggactccc gtcactgtct ctagcggtgg cggagggtct     1920

gggggtggcg gatccggagg tggtggctct gcacaagaca tccagatgac ccagtctcca     1980

agcagcctgt ctgcaagcgt gggggacagg gtcaccatga cctgcagtgc cagctcaagt     2040

gtaagttaca tgaactggta ccagcagaag ccgggcaagg cccccaaaag atggatttat     2100

gactcatcca aactggcttc tggagtccct gctcgcttca gtggcagtgg gtctgggacc     2160

gactataccc tcacaatcag cagcctgcag cccgaagatt tcgccactta ttactgccag     2220

cagtggagtc gtaacccacc cacgttcgga ggggggacca agctacaaat tacatcctcc     2280

agctaa                                                                2286


<210>  63
<211>  741
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized TSC252 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H91 linker)

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Asn Ser Leu Ala Asn Gln 
465                 470                 475                 480 


Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser Gln Val 
                485                 490                 495     


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu 
            500                 505                 510         


Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met 
        515                 520                 525             


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
    530                 535                 540                 


Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
545                 550                 555                 560 


Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln 
                565                 570                 575     


Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg 
            580                 585                 590         


Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly 
        595                 600                 605             


Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro 
625                 630                 635                 640 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser 
                645                 650                 655     


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly 
            660                 665                 670         


Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly 
        675                 680                 685             


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
    690                 695                 700                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
705                 710                 715                 720 


Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln 
                725                 730                 735     


Ile Thr Ser Ser Ser 
            740     


<210>  64
<211>  2250
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized TSC295 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H9 linker)

<400>  64
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtgggagccc accttcaccg     1500

aattctcagg tccagctggt ggagtctggg ggcggagtgg tgcagcctgg gcggtcactg     1560

aggctgtcct gcaaggcttc tggctacacc tttactagat ctacgatgca ctgggtaagg     1620

caggcccctg gacaaggtct ggaatggatt ggatacatta atcctagcag tgcttatact     1680

aattacaatc agaaattcaa ggacaggttc acaatcagcg cagacaaatc caagagcaca     1740

gccttcctgc agatggacag cctgaggccc gaggacaccg gcgtctattt ctgtgcacgg     1800

ccccaagtcc actatgatta caacgggttt ccttactggg gccaagggac tcccgtcact     1860

gtctctagcg gtggcggagg gtctgggggt ggcggatccg gaggtggtgg ctctgcacaa     1920

gacatccaga tgacccagtc tccaagcagc ctgtctgcaa gcgtggggga cagggtcacc     1980

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagccgggc     2040

aaggccccca aaagatggat ttatgactca tccaaactgg cttctggagt ccctgctcgc     2100

ttcagtggca gtgggtctgg gaccgactat accctcacaa tcagcagcct gcagcccgaa     2160

gatttcgcca cttattactg ccagcagtgg agtcgtaacc cacccacgtt cggagggggg     2220

accaagctac aaattacatc ctccagctaa                                      2250


<210>  65
<211>  729
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized TSC295 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H9 linker)

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Pro Ser Pro 
465                 470                 475                 480 


Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
                485                 490                 495     


Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            500                 505                 510         


Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        515                 520                 525             


Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln 
    530                 535                 540                 


Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr 
545                 550                 555                 560 


Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr 
                565                 570                 575     


Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr 
            580                 585                 590         


Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met 
    610                 615                 620                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
625                 630                 635                 640 


Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
                645                 650                 655     


Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys 
            660                 665                 670         


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        675                 680                 685             


Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    690                 695                 700                 


Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly 
705                 710                 715                 720 


Thr Lys Leu Gln Ile Thr Ser Ser Ser 
                725                 


<210>  66
<211>  2283
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized TSC296 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H94 linker)

<400>  66
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttctggtgg aggcggttca     1500

ggcggaggtg gctccggcgg tggcggatcg ccgaattctc aggtccagct ggtggagtct     1560

gggggcggag tggtgcagcc tgggcggtca ctgaggctgt cctgcaaggc ttctggctac     1620

acctttacta gatctacgat gcactgggta aggcaggccc ctggacaagg tctggaatgg     1680

attggataca ttaatcctag cagtgcttat actaattaca atcagaaatt caaggacagg     1740

ttcacaatca gcgcagacaa atccaagagc acagccttcc tgcagatgga cagcctgagg     1800

cccgaggaca ccggcgtcta tttctgtgca cggccccaag tccactatga ttacaacggg     1860

tttccttact ggggccaagg gactcccgtc actgtctcta gcggtggcgg agggtctggg     1920

ggtggcggat ccggaggtgg tggctctgca caagacatcc agatgaccca gtctccaagc     1980

agcctgtctg caagcgtggg ggacagggtc accatgacct gcagtgccag ctcaagtgta     2040

agttacatga actggtacca gcagaagccg ggcaaggccc ccaaaagatg gatttatgac     2100

tcatccaaac tggcttctgg agtccctgct cgcttcagtg gcagtgggtc tgggaccgac     2160

tataccctca caatcagcag cctgcagccc gaagatttcg ccacttatta ctgccagcag     2220

tggagtcgta acccacccac gttcggaggg gggaccaagc tacaaattac atcctccagc     2280

taa                                                                   2283


<210>  67
<211>  740
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized TSC296 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H94 linker)

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Asn Ser Gln Val Gln 
                485                 490                 495     


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            500                 505                 510         


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His 
        515                 520                 525             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
    530                 535                 540                 


Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg 
545                 550                 555                 560 


Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met 
                565                 570                 575     


Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro 
            580                 585                 590         


Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
        595                 600                 605             


Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser 
625                 630                 635                 640 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala 
                645                 650                 655     


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
            660                 665                 670         


Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val 
        675                 680                 685             


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
    690                 695                 700                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
705                 710                 715                 720 


Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile 
                725                 730                 735     


Thr Ser Ser Ser 
            740 


<210>  68
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized TSC301 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H105 linker)

<400>  68
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttctggtgg aggcggttca     1500

ggcggaggtg gctccggcgg tggcggatcg caggtccagc tggtggagtc tgggggcgga     1560

gtggtgcagc ctgggcggtc actgaggctg tcctgcaagg cttctggcta cacctttact     1620

agatctacga tgcactgggt aaggcaggcc cctggacaag gtctggaatg gattggatac     1680

attaatccta gcagtgctta tactaattac aatcagaaat tcaaggacag gttcacaatc     1740

agcgcagaca aatccaagag cacagccttc ctgcagatgg acagcctgag gcccgaggac     1800

accggcgtct atttctgtgc acggccccaa gtccactatg attacaacgg gtttccttac     1860

tggggccaag ggactcccgt cactgtctct agcggtggcg gagggtctgg gggtggcgga     1920

tccggaggtg gtggctctgc acaagacatc cagatgaccc agtctccaag cagcctgtct     1980

gcaagcgtgg gggacagggt caccatgacc tgcagtgcca gctcaagtgt aagttacatg     2040

aactggtacc agcagaagcc gggcaaggcc cccaaaagat ggatttatga ctcatccaaa     2100

ctggcttctg gagtccctgc tcgcttcagt ggcagtgggt ctgggaccga ctataccctc     2160

acaatcagca gcctgcagcc cgaagatttc gccacttatt actgccagca gtggagtcgt     2220

aacccaccca cgttcggagg ggggaccaag ctacaaatta catcctccag ctaa           2274


<210>  69
<211>  737
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized TSC301 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H105 linker)

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
                485                 490                 495     


Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
            500                 505                 510         


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg 
        515                 520                 525             


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
    530                 535                 540                 


Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile 
545                 550                 555                 560 


Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu 
                565                 570                 575     


Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His 
            580                 585                 590         


Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr 
        595                 600                 605             


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
625                 630                 635                 640 


Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
                645                 650                 655     


Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
            660                 665                 670         


Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg 
        675                 680                 685             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
    690                 695                 700                 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg 
705                 710                 715                 720 


Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser 
                725                 730                 735     


Ser 
    


<210>  70
<211>  2280
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized TSC302 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 scFv,
       with H106 linker)

<400>  70
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctcagg tccagctggt ggagtctggg     1560

ggcggagtgg tgcagcctgg gcggtcactg aggctgtcct gcaaggcttc tggctacacc     1620

tttactagat ctacgatgca ctgggtaagg caggcccctg gacaaggtct ggaatggatt     1680

ggatacatta atcctagcag tgcttatact aattacaatc agaaattcaa ggacaggttc     1740

acaatcagcg cagacaaatc caagagcaca gccttcctgc agatggacag cctgaggccc     1800

gaggacaccg gcgtctattt ctgtgcacgg ccccaagtcc actatgatta caacgggttt     1860

ccttactggg gccaagggac tcccgtcact gtctctagcg gtggcggagg gtctgggggt     1920

ggcggatccg gaggtggtgg ctctgcacaa gacatccaga tgacccagtc tccaagcagc     1980

ctgtctgcaa gcgtggggga cagggtcacc atgacctgca gtgccagctc aagtgtaagt     2040

tacatgaact ggtaccagca gaagccgggc aaggccccca aaagatggat ttatgactca     2100

tccaaactgg cttctggagt ccctgctcgc ttcagtggca gtgggtctgg gaccgactat     2160

accctcacaa tcagcagcct gcagcccgaa gatttcgcca cttattactg ccagcagtgg     2220

agtcgtaacc cacccacgtt cggagggggg accaagctac aaattacatc ctccagctaa     2280


<210>  71
<211>  739
<212>  PRT
<213>  Artificial

<220>
<223>  Humanizede TSC302 Scorpion (huVL-VH#2 107-1A4 scFv-Fc-DRA222 
       scFv, with H106 linker)

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Gln Val Gln Leu 
                485                 490                 495     


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
            500                 505                 510         


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp 
        515                 520                 525             


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn 
    530                 535                 540                 


Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe 
545                 550                 555                 560 


Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp 
                565                 570                 575     


Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln 
            580                 585                 590         


Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro 
        595                 600                 605             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
625                 630                 635                 640 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser 
                645                 650                 655     


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            660                 665                 670         


Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro 
        675                 680                 685             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
    690                 695                 700                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp 
705                 710                 715                 720 


Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
                725                 730                 735     


Ser Ser Ser 
            


<210>  72
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  HuM291 VL

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  73
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  HuM291 VH

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Gly Tyr Thr His Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Asp Tyr Asp Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  74
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  74

Gly Gly Gly Gly Ser 
1               5   


<210>  75
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  75

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  76
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  76

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  77
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  77

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  78
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  78

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  79
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  a secretory signal sequence

<400>  79

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  80
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  a wild-type human igG1 CH1 domain

<400>  80

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  81
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  a wild-type human CK domain

<400>  81

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  82
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  a wild-type human CA domain

<400>  82

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  83
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  a CK domain

<400>  83

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  84
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  a CA domain

<400>  84

Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Ser Ser 
            100                 105 


<210>  85
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  a wild-type human IgG1 CH2 domain

<400>  85

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  86
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  a wild-type human IgG1 CH2 domain

<400>  86

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  87
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01 VL CDR1

<400>  87

Arg Ala Ser Gln Asp Ile Gly Ser Ser Leu Ser Trp Leu 
1               5                   10              


<210>  88
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01 VL CDR2

<400>  88

Arg Leu Ile Tyr Ser Thr Ser Ser Leu Asp Ser 
1               5                   10      


<210>  89
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01 VL CDR3

<400>  89

Leu Gln Tyr Ala Ser Ser Pro Trp Thr 
1               5                   


<210>  90
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01 VL CDR1

<400>  90

Leu Ala Ser Gln Thr Ile Gly Thr Trp Leu Ala Trp Tyr 
1               5                   10              


<210>  91
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01 VL CDR2

<400>  91

Leu Leu Ile Tyr Ala Ala Thr Ser Leu Ala Asp 
1               5                   10      


<210>  92
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01 VL CDR3

<400>  92

Gln Gln Leu Tyr Asn Thr Pro Trp Thr 
1               5                   


<210>  93
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01 VH CDR1

<400>  93

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile His 
1               5                   10  


<210>  94
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01 VH CDR2

<400>  94

Trp Ile Gly Tyr Ile Tyr Pro Thr Thr Gly Tyr Thr Glu Ser Asn Gln 
1               5                   10                  15      


Lys Phe Lys Asp 
            20  


<210>  95
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01 VH CDR3

<400>  95

Phe Leu Leu Arg Pro Trp Tyr Phe Asp Val 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01 VH CDR1

<400>  96

Asp Tyr Thr Leu Thr Asp Phe Tyr Met Asn 
1               5                   10  


<210>  97
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01 VH CDR2

<400>  97

Trp Ile Gly Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu 
1               5                   10                  15      


Lys Phe Arg Asp 
            20  


<210>  98
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01 VH CDR3

<400>  98

Ala Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr 
1               5                   10                  


<210>  99
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01 murine VL

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  100
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01 murine VL

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Asp Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Val Ser Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  101
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01 murine VH

<400>  101

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Thr Thr Gly Tyr Thr Glu Ser Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Phe Leu Leu Arg Pro Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  102
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01 murine VH

<400>  102

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Thr Leu Thr Asp Phe 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Leu 
        115                 120     


<210>  103
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01 murine VH variant

<400>  103

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Thr Leu Thr Asp Phe 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Ile Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  104
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01h6 humanized VL

<400>  104

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  105
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01h7 humanized VL

<400>  105

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Ala Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  106
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01h2 humanized VL

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  107
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01h8 humanized VH

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Thr Thr Gly Tyr Thr Glu Ser Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Phe Leu Leu Arg Pro Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  108
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01h9 humanized VH

<400>  108

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Thr Thr Gly Tyr Thr Glu Ser Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Phe Leu Leu Arg Pro Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  109
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  RON-e01h10 humanized VH

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Thr Thr Gly Tyr Thr Glu Ser Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Phe Leu Leu Arg Pro Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  110
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01h4 humanized VH

<400>  110

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Asp Tyr Thr Leu Thr Asp Phe 
            20                  25                  30          


Tyr Met Asn Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  111
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  RON-f01h5 humanized VH

<400>  111

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Thr Leu Thr Asp Phe 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  112
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  sss(s)-hlgG1 hinge

<400>  112

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  113
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  csc(s)-hlgG1 hinge

<400>  113

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  114
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  ssc(s)-hlgG1 hinge

<400>  114

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  115
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  scc(s)-hlg1 hinge

<400>  115

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  116
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  css(s)-hlgG1 hinge

<400>  116

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  117
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  scs(s)-hlgG1 hinge

<400>  117

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  118
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  ccc(s)-hlgG1 hinge

<400>  118

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  119
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  ccc(p)-hlgG1 hinge

<400>  119

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  120
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  sss(p)-hlgG1 hinge

<400>  120

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  121
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  csc(p)-hlgG1 hinge

<400>  121

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  122
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  ssc(p)-hlgG1 hinge

<400>  122

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  123
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  scc(p)-hlgG1 hinge

<400>  123

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  124
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  css(p)-hlgG1 hinge

<400>  124

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  125
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  scs(p)-hlgG1 hinge

<400>  125

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  126
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Scppcp

<400>  126

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  127
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  STD1

<400>  127

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  128
<211>  38
<212>  PRT
<213>  Artificial

<220>
<223>  STD2

<400>  128

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser 
        35              


<210>  129
<211>  2
<212>  PRT
<213>  Artificial

<220>
<223>  H1

<400>  129

Asn Ser 
1       


<210>  130
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  H2

<400>  130

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  131
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H3

<400>  131

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  132
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  H4

<400>  132

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  133
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H5

<400>  133

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  134
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  H6

<400>  134

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  135
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  H7

<400>  135

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  136
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  H9

<400>  136

Gly Ser Pro Pro Ser Pro Asn Ser 
1               5               


<210>  137
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  (G4S)3

<400>  137

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  138
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  H105

<400>  138

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  139
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  (G4S)4

<400>  139

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  140
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  H75 (NKG2A quadruple mutant)

<400>  140

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  141
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  H83 (NKG2A derived)

<400>  141

Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  142
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  H106 (NKG2A derived)

<400>  142

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser 
        


<210>  143
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  H81 (NKG2D derived)

<400>  143

Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  


<210>  144
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  H91 (NKG2D derived)

<400>  144

Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  145
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  H94

<400>  145

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  146
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H16

<400>  146

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  147
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  H17

<400>  147

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  148
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H18

<400>  148

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  149
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  H19

<400>  149

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  150
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H20

<400>  150

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Asn Ser 
1               5                   10                  15  


<210>  151
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  H21

<400>  151

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  152
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H22

<400>  152

Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 
1               5                   10                  15  


<210>  153
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  H23

<400>  153

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  154
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H24

<400>  154

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asn Ser 
1               5                   10                  15  


<210>  155
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  H25

<400>  155

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  156
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H26

<400>  156

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  157
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  H27

<400>  157

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  158
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H28

<400>  158

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser 
1               5                   10                  15  


<210>  159
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H30

<400>  159

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Asn Ser 
1               5                   10                  15  


<210>  160
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H32

<400>  160

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10                  15  


<210>  161
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  H33

<400>  161

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  162
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  H36

<400>  162

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  163
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  H40

<400>  163

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  164
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  H41

<400>  164

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  165
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  H42

<400>  165

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  166
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  H44

<400>  166

Gly Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  167
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  H45

<400>  167

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  168
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  H46

<400>  168

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 
1               5                   10          


<210>  169
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H47

<400>  169

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  170
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  H48

<400>  170

Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10      


<210>  171
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H50

<400>  171

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  172
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H51

<400>  172

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  173
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  H52

<400>  173

Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ser 
1               5                   10      


<210>  174
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  H53

<400>  174

Ser Gln Pro Glu Ile Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10                  15      


<210>  175
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  H54

<400>  175

Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  176
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H55

<400>  176

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  177
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  H56

<400>  177

Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10          


<210>  178
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  H57

<400>  178

Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10  


<210>  179
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H58

<400>  179

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  180
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H59

<400>  180

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  181
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  H60

<400>  181

Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Asn Ser 
1               5                   10                  15  


<210>  182
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  H61

<400>  182

Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
1               5                   10                  15      


Asp Cys Pro Asn Ser 
            20      


<210>  183
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  H62

<400>  183

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Cys Pro Asn Ser 
            20      


<210>  184
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  H63

<400>  184

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  185
<211>  2307
<212>  DNA
<213>  TSC275 (hu4C04 x DRA222 null2 Scorpion)

<400>  185
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc tggcaagtca gaccattggt acatggttag catggtatca gcagaaacca      180

gggaaagccc ctaagctcct gatttatgct gcaaccagct tggcagatgg ggtcccatca      240

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcaacaa ctttacaata ctccgtggac gttcggcgga      360

gggaccaagg tggagatcaa agggggtgga ggctctggtg gcggtggctc tggcggaggt      420

ggatccggcg ggggtggctc tgaggtccag ctggtacagt ctggggctga ggtgaagaag      480

cctggggcta cagtgaaaat ctcctgcaag gtttctgact acacactcac tgacttctat      540

atgaactggg tgcaacaggc ccctggaaaa gggcttgagt ggattgggag gatttatcct      600

ggaaccgata aaactagata caatgagaaa ttcagggaca gagtcaccat aaccgcggac      660

acgtctacag acacagccta catggagctg agcagcctga gatctgagga cacggccgtg      720

tattactgtg caagatccgc ctactatggt aactacgttg ctatggacta ctgggggcaa      780

gggaccacgg tcaccgtctc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

cagaggcaca acaattcttc cctgaataca ggaactcaga tggcaggtca ttctccgaat     1560

tctcaggtcc agctggtgga gtctgggggc ggagtggtgc agcctgggcg gtcactgagg     1620

ctgtcctgca aggcttctgg ctacaccttt actagatcta cgatgcactg ggtaaggcag     1680

gcccctggac aaggtctgga atggattgga tacattaatc ctagcagtgc ttatactaat     1740

tacaatcaga aattcaagga caggttcaca atcagcgcag acaaatccaa gagcacagcc     1800

ttcctgcaga tggacagcct gaggcccgag gacaccggcg tctatttctg tgcacggccc     1860

caagtccact atgattacaa cgggtttcct tactggggcc aagggactcc cgtcactgtc     1920

tctagcggtg gcggagggtc tgggggtggc ggatccggag gtggtggctc tgcacaagac     1980

atccagatga cccagtctcc aagcagcctg tctgcaagcg tgggggacag ggtcaccatg     2040

acctgcagtg ccagctcaag tgtaagttac atgaactggt accagcagaa gccgggcaag     2100

gcccccaaaa gatggattta tgactcatcc aaactggctt ctggagtccc tgctcgcttc     2160

agtggcagtg ggtctgggac cgactatacc ctcacaatca gcagcctgca gcccgaagat     2220

ttcgccactt attactgcca gcagtggagt cgtaacccac ccacgttcgg aggggggacc     2280

aagctacaaa ttacatcctc cagctaa                                         2307


<210>  186
<211>  748
<212>  PRT
<213>  Artificial

<220>
<223>  TSC275 (hu4C04 x DRA222 null2 Scorpion)

<400>  186

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Val Ser Asp Tyr Thr Leu Thr Asp Phe Tyr 
145                 150                 155                 160 


Met Asn Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe Arg 
            180                 185                 190         


Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
                485                 490                 495     


His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            500                 505                 510         


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
        515                 520                 525             


Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln 
    530                 535                 540                 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn 
545                 550                 555                 560 


Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser 
                565                 570                 575     


Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
            580                 585                 590         


Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly 
        595                 600                 605             


Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp 
625                 630                 635                 640 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                645                 650                 655     


Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
            660                 665                 670         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
        675                 680                 685             


Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    690                 695                 700                 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
705                 710                 715                 720 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745             


<210>  187
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  hu4C04 VL

<400>  187

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  188
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  hu4C04 VH

<400>  188

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Asp Tyr Thr Leu Thr Asp Phe 
            20                  25                  30          


Tyr Met Asn Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  189
<211>  2307
<212>  DNA
<213>  TSC277 (hu4C04 (A43K Q240E) x DRA222 null2 Scorpion)

<400>  189
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc tggcaagtca gaccattggt acatggttag catggtatca gcagaaacca      180

gggaaaaagc ctaagctcct gatttatgct gcaaccagct tggcagatgg ggtcccatca      240

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcaacaa ctttacaata ctccgtggac gttcggcgga      360

gggaccaagg tggagatcaa agggggtgga ggctctggtg gcggtggctc tggcggaggt      420

ggatccggcg ggggtggctc tgaggtccag ctggtacagt ctggggctga ggtgaagaag      480

cctggggcta cagtgaaaat ctcctgcaag gtttctgact acacactcac tgacttctat      540

atgaactggg tgcaacaggc ccctggaaaa gggcttgagt ggattgggag gatttatcct      600

ggaaccgata aaactagata caatgagaaa ttcagggaca gagtcaccat aaccgcggac      660

acgtctacag acacagccta catggagctg agcagcctga gatctgagga cacggccgtg      720

tattactgtg caagatccgc ctactatggt aactacgttg ctatggacta ctggggggag      780

gggaccacgg tcaccgtctc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

cagaggcaca acaattcttc cctgaataca ggaactcaga tggcaggtca ttctccgaat     1560

tctcaggtcc agctggtgga gtctgggggc ggagtggtgc agcctgggcg gtcactgagg     1620

ctgtcctgca aggcttctgg ctacaccttt actagatcta cgatgcactg ggtaaggcag     1680

gcccctggac aaggtctgga atggattgga tacattaatc ctagcagtgc ttatactaat     1740

tacaatcaga aattcaagga caggttcaca atcagcgcag acaaatccaa gagcacagcc     1800

ttcctgcaga tggacagcct gaggcccgag gacaccggcg tctatttctg tgcacggccc     1860

caagtccact atgattacaa cgggtttcct tactggggcc aagggactcc cgtcactgtc     1920

tctagcggtg gcggagggtc tgggggtggc ggatccggag gtggtggctc tgcacaagac     1980

atccagatga cccagtctcc aagcagcctg tctgcaagcg tgggggacag ggtcaccatg     2040

acctgcagtg ccagctcaag tgtaagttac atgaactggt accagcagaa gccgggcaag     2100

gcccccaaaa gatggattta tgactcatcc aaactggctt ctggagtccc tgctcgcttc     2160

agtggcagtg ggtctgggac cgactatacc ctcacaatca gcagcctgca gcccgaagat     2220

ttcgccactt attactgcca gcagtggagt cgtaacccac ccacgttcgg aggggggacc     2280

aagctacaaa ttacatcctc cagctaa                                         2307


<210>  190
<211>  748
<212>  PRT
<213>  Artificial

<220>
<223>  TSC277 (hu4C04 (A43K Q240E) x DRA222 null2 Scorpion)

<400>  190

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Lys Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Val Ser Asp Tyr Thr Leu Thr Asp Phe Tyr 
145                 150                 155                 160 


Met Asn Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe Arg 
            180                 185                 190         


Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly Glu 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
                485                 490                 495     


His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            500                 505                 510         


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
        515                 520                 525             


Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln 
    530                 535                 540                 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn 
545                 550                 555                 560 


Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser 
                565                 570                 575     


Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
            580                 585                 590         


Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly 
        595                 600                 605             


Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp 
625                 630                 635                 640 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                645                 650                 655     


Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
            660                 665                 670         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
        675                 680                 685             


Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    690                 695                 700                 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
705                 710                 715                 720 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745             


<210>  191
<211>  2307
<212>  DNA
<213>  TSC278 (hu4C04 (A43T) x DRA222 null2 Scorpion)

<400>  191
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc tggcaagtca gaccattggt acatggttag catggtatca gcagaaacca      180

gggaaaaccc ctaagctcct gatttatgct gcaaccagct tggcagatgg ggtcccatca      240

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcaacaa ctttacaata ctccgtggac gttcggcgga      360

gggaccaagg tggagatcaa agggggtgga ggctctggtg gcggtggctc tggcggaggt      420

ggatccggcg ggggtggctc tgaggtccag ctggtacagt ctggggctga ggtgaagaag      480

cctggggcta cagtgaaaat ctcctgcaag gtttctgact acacactcac tgacttctat      540

atgaactggg tgcaacaggc ccctggaaaa gggcttgagt ggattgggag gatttatcct      600

ggaaccgata aaactagata caatgagaaa ttcagggaca gagtcaccat aaccgcggac      660

acgtctacag acacagccta catggagctg agcagcctga gatctgagga cacggccgtg      720

tattactgtg caagatccgc ctactatggt aactacgttg ctatggacta ctgggggcaa      780

gggaccacgg tcaccgtctc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

cagaggcaca acaattcttc cctgaataca ggaactcaga tggcaggtca ttctccgaat     1560

tctcaggtcc agctggtgga gtctgggggc ggagtggtgc agcctgggcg gtcactgagg     1620

ctgtcctgca aggcttctgg ctacaccttt actagatcta cgatgcactg ggtaaggcag     1680

gcccctggac aaggtctgga atggattgga tacattaatc ctagcagtgc ttatactaat     1740

tacaatcaga aattcaagga caggttcaca atcagcgcag acaaatccaa gagcacagcc     1800

ttcctgcaga tggacagcct gaggcccgag gacaccggcg tctatttctg tgcacggccc     1860

caagtccact atgattacaa cgggtttcct tactggggcc aagggactcc cgtcactgtc     1920

tctagcggtg gcggagggtc tgggggtggc ggatccggag gtggtggctc tgcacaagac     1980

atccagatga cccagtctcc aagcagcctg tctgcaagcg tgggggacag ggtcaccatg     2040

acctgcagtg ccagctcaag tgtaagttac atgaactggt accagcagaa gccgggcaag     2100

gcccccaaaa gatggattta tgactcatcc aaactggctt ctggagtccc tgctcgcttc     2160

agtggcagtg ggtctgggac cgactatacc ctcacaatca gcagcctgca gcccgaagat     2220

ttcgccactt attactgcca gcagtggagt cgtaacccac ccacgttcgg aggggggacc     2280

aagctacaaa ttacatcctc cagctaa                                         2307


<210>  192
<211>  748
<212>  PRT
<213>  Artificial

<220>
<223>  TSC278 (hu4C04 (A43T) x DRA222 null2 Scorpion)

<400>  192

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Val Ser Asp Tyr Thr Leu Thr Asp Phe Tyr 
145                 150                 155                 160 


Met Asn Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe Arg 
            180                 185                 190         


Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
                485                 490                 495     


His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            500                 505                 510         


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
        515                 520                 525             


Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln 
    530                 535                 540                 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn 
545                 550                 555                 560 


Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser 
                565                 570                 575     


Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
            580                 585                 590         


Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly 
        595                 600                 605             


Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp 
625                 630                 635                 640 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                645                 650                 655     


Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
            660                 665                 670         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
        675                 680                 685             


Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    690                 695                 700                 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
705                 710                 715                 720 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745             


<210>  193
<211>  2307
<212>  DNA
<213>  TSC279 (hu4C04 (Q165R) x DRA222 null2 Scorpion )

<400>  193
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc tggcaagtca gaccattggt acatggttag catggtatca gcagaaacca      180

gggaaagccc ctaagctcct gatttatgct gcaaccagct tggcagatgg ggtcccatca      240

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      300

gaagattttg caacttacta ctgtcaacaa ctttacaata ctccgtggac gttcggcgga      360

gggaccaagg tggagatcaa agggggtgga ggctctggtg gcggtggctc tggcggaggt      420

ggatccggcg ggggtggctc tgaggtccag ctggtacagt ctggggctga ggtgaagaag      480

cctggggcta cagtgaaaat ctcctgcaag gtttctgact acacactcac tgacttctat      540

atgaactggg tgagacaggc ccctggaaaa gggcttgagt ggattgggag gatttatcct      600

ggaaccgata aaactagata caatgagaaa ttcagggaca gagtcaccat aaccgcggac      660

acgtctacag acacagccta catggagctg agcagcctga gatctgagga cacggccgtg      720

tattactgtg caagatccgc ctactatggt aactacgttg ctatggacta ctgggggcaa      780

gggaccacgg tcaccgtctc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

cagaggcaca acaattcttc cctgaataca ggaactcaga tggcaggtca ttctccgaat     1560

tctcaggtcc agctggtgga gtctgggggc ggagtggtgc agcctgggcg gtcactgagg     1620

ctgtcctgca aggcttctgg ctacaccttt actagatcta cgatgcactg ggtaaggcag     1680

gcccctggac aaggtctgga atggattgga tacattaatc ctagcagtgc ttatactaat     1740

tacaatcaga aattcaagga caggttcaca atcagcgcag acaaatccaa gagcacagcc     1800

ttcctgcaga tggacagcct gaggcccgag gacaccggcg tctatttctg tgcacggccc     1860

caagtccact atgattacaa cgggtttcct tactggggcc aagggactcc cgtcactgtc     1920

tctagcggtg gcggagggtc tgggggtggc ggatccggag gtggtggctc tgcacaagac     1980

atccagatga cccagtctcc aagcagcctg tctgcaagcg tgggggacag ggtcaccatg     2040

acctgcagtg ccagctcaag tgtaagttac atgaactggt accagcagaa gccgggcaag     2100

gcccccaaaa gatggattta tgactcatcc aaactggctt ctggagtccc tgctcgcttc     2160

agtggcagtg ggtctgggac cgactatacc ctcacaatca gcagcctgca gcccgaagat     2220

ttcgccactt attactgcca gcagtggagt cgtaacccac ccacgttcgg aggggggacc     2280

aagctacaaa ttacatcctc cagctaa                                         2307


<210>  194
<211>  748
<212>  PRT
<213>  Artificial

<220>
<223>  TSC279 (hu4C04 (Q165R) x DRA222 null2 Scorpion )

<400>  194

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Asn Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Val Ser Asp Tyr Thr Leu Thr Asp Phe Tyr 
145                 150                 155                 160 


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Arg Ile Tyr Pro Gly Thr Asp Lys Thr Arg Tyr Asn Glu Lys Phe Arg 
            180                 185                 190         


Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Ala Tyr Tyr Gly Asn Tyr Val Ala Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
                485                 490                 495     


His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            500                 505                 510         


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
        515                 520                 525             


Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln 
    530                 535                 540                 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn 
545                 550                 555                 560 


Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser 
                565                 570                 575     


Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
            580                 585                 590         


Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly 
        595                 600                 605             


Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp 
625                 630                 635                 640 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                645                 650                 655     


Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
            660                 665                 670         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp 
        675                 680                 685             


Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    690                 695                 700                 


Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
705                 710                 715                 720 


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe 
                725                 730                 735     


Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745             


<210>  195
<211>  2316
<212>  DNA
<213>  TSC233  (HD37 x DRA221 scorpion, H75 linker)

<400>  195
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      180

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      240

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggaga aggtggatgc tgcaacctat cactgccagc aaagtactga ggatccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaaggtggcg gtggttcggg cggtggtggg      420

tcgggtggcg gcggagctag ccaggttcag ctgcagcagt ctggggctga gctggtgagg      480

cctgggtcct cagtgaagat ttcctgcaag gcttctggct atgcattcag tagctactgg      540

atgaactggg tgaagcagag gcctggacag ggtcttgagt ggattggaca gatttggcct      600

ggagatggtg atactaacta caatggaaag ttcaagggta aagccactct gactgcagac      660

gaatcctcca gcacagccta catgcaactc agcagcctag catctgagga ctctgcggtc      720

tatttctgtg caagacggga gactacgacg gtaggccgtt attactatgc tatggactac      780

tggggtcaag gaacctcagt caccgtctcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacgc gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggtc agaggcacaa caattcttcc ctgaatacag gaactcagat ggcaggtcat     1560

tctccgaatt ctcaggtcca gctggtggag tctgggggcg gagtggtgca gcctgggcgg     1620

tcactgaggc tgtcctgcaa ggcttctggc tacaccttta ctagatctac gatgcactgg     1680

gtaaggcagg cccctggaca aggtctggaa tggattggat acattaatcc tagcagtgct     1740

tatactaatt acaatcagaa attcaaggac aggttcacaa tcagcgcaga caaatccaag     1800

agcacagcct tcctgcagat ggacagcctg aggcccgagg acaccggcgt ctatttctgt     1860

gcacggcccc aagtccacta tgattacaac gggtttcctt actggggcca agggactccc     1920

gtcactgtct ctagcggtgg cggagggtct gggggtggcg gatccggagg tggtggctct     1980

gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg     2040

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagaag     2100

ccgggcaagg cccccaaact cctcatttat gactcatcca aactggcttc tggagtccct     2160

gctcgcttca gtggcagtgg gtctgggacc gactataccc tcacaatcag cagcctgcag     2220

cccgaagatt tcgccactta ttactgccag cagtggagtc gtaacccacc cactttcggc     2280

ggagggacca aggtggagat caaatcctcc agctaa                               2316


<210>  196
<211>  751
<212>  PRT
<213>  Artificial

<220>
<223>  TSC233  (HD37 x DRA221 scorpion, H75 linker)

<400>  196

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln 
                485                 490                 495     


Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly 
            500                 505                 510         


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
        515                 520                 525             


Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala 
    530                 535                 540                 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
545                 550                 555                 560 


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala 
                565                 570                 575     


Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
            580                 585                 590         


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp 
        595                 600                 605             


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                645                 650                 655     


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            660                 665                 670         


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        675                 680                 685             


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    690                 695                 700                 


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
705                 710                 715                 720 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                725                 730                 735     


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ser Ser Ser 
            740                 745                 750     


<210>  197
<211>  2316
<212>  DNA
<213>  TSC234 (HD37 x DRA222 scorpion, H75 linker)

<400>  197
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      180

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      240

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggaga aggtggatgc tgcaacctat cactgccagc aaagtactga ggatccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaaggtggcg gtggttcggg cggtggtggg      420

tcgggtggcg gcggagctag ccaggttcag ctgcagcagt ctggggctga gctggtgagg      480

cctgggtcct cagtgaagat ttcctgcaag gcttctggct atgcattcag tagctactgg      540

atgaactggg tgaagcagag gcctggacag ggtcttgagt ggattggaca gatttggcct      600

ggagatggtg atactaacta caatggaaag ttcaagggta aagccactct gactgcagac      660

gaatcctcca gcacagccta catgcaactc agcagcctag catctgagga ctctgcggtc      720

tatttctgtg caagacggga gactacgacg gtaggccgtt attactatgc tatggactac      780

tggggtcaag gaacctcagt caccgtctcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacgc gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggtc agaggcacaa caattcttcc ctgaatacag gaactcagat ggcaggtcat     1560

tctccgaatt ctcaggtcca gctggtggag tctgggggcg gagtggtgca gcctgggcgg     1620

tcactgaggc tgtcctgcaa ggcttctggc tacaccttta ctagatctac gatgcactgg     1680

gtaaggcagg cccctggaca aggtctggaa tggattggat acattaatcc tagcagtgct     1740

tatactaatt acaatcagaa attcaaggac aggttcacaa tcagcgcaga caaatccaag     1800

agcacagcct tcctgcagat ggacagcctg aggcccgagg acaccggcgt ctatttctgt     1860

gcacggcccc aagtccacta tgattacaac gggtttcctt actggggcca agggactccc     1920

gtcactgtct ctagcggtgg cggagggtct gggggtggcg gatccggagg tggtggctct     1980

gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg     2040

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagaag     2100

ccgggcaagg cccccaaaag atggatttat gactcatcca aactggcttc tggagtccct     2160

gctcgcttca gtggcagtgg gtctgggacc gactataccc tcacaatcag cagcctgcag     2220

cccgaagatt tcgccactta ttactgccag cagtggagtc gtaacccacc cacgttcgga     2280

ggggggacca agctacaaat tacatcctcc agctaa                               2316


<210>  198
<211>  751
<212>  PRT
<213>  Artificial

<220>
<223>  TSC234 (HD37 x DRA222 scorpion, H75 linker)

<400>  198

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln 
                485                 490                 495     


Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly 
            500                 505                 510         


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
        515                 520                 525             


Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala 
    530                 535                 540                 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
545                 550                 555                 560 


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala 
                565                 570                 575     


Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
            580                 585                 590         


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp 
        595                 600                 605             


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                645                 650                 655     


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            660                 665                 670         


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        675                 680                 685             


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    690                 695                 700                 


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
705                 710                 715                 720 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                725                 730                 735     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745                 750     


<210>  199
<211>  2325
<212>  DNA
<213>  TSC235 (HD37 x DRA224 scorpion, H75 linker)

<400>  199
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      180

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      240

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggaga aggtggatgc tgcaacctat cactgccagc aaagtactga ggatccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaaggtggcg gtggttcggg cggtggtggg      420

tcgggtggcg gcggagctag ccaggttcag ctgcagcagt ctggggctga gctggtgagg      480

cctgggtcct cagtgaagat ttcctgcaag gcttctggct atgcattcag tagctactgg      540

atgaactggg tgaagcagag gcctggacag ggtcttgagt ggattggaca gatttggcct      600

ggagatggtg atactaacta caatggaaag ttcaagggta aagccactct gactgcagac      660

gaatcctcca gcacagccta catgcaactc agcagcctag catctgagga ctctgcggtc      720

tatttctgtg caagacggga gactacgacg gtaggccgtt attactatgc tatggactac      780

tggggtcaag gaacctcagt caccgtctcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacgc gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggtc agaggcacaa caattcttcc ctgaatacag gaactcagat ggcaggtcat     1560

tctccgaatt ctcaggtcca gcttgtgcag tctggggctg aggtgaagaa gcctggggcc     1620

tcagtgaagg tttcctgcaa ggcttctgga tacaccttca ctagatctac gatgcactgg     1680

gtgcgccagg cccccggaca aaggcttgag tggatgggat acattaatcc tagcagtgct     1740

tatactaatt acaatcagaa attcaaggac agagtcacca ttaccaggga cacatccgcg     1800

agcacagcct acatggagct gagcagcctg agatctgaag acacggctgt gtattactgt     1860

gcgagacccc aagtccacta tgattacaac gggtttcctt actggggcca aggaaccctg     1920

gtcaccgtct cctcaggtgg aggcggttca ggcggaggtg gatccggcgg tggcggatcg     1980

ggtggcggcg gatctgaaat tgtgttgaca cagtctccag ccaccctgtc tttgtctcca     2040

ggggaaagag ccaccctctc ctgcagtgcc agctcaagtg taagttacat gaactggtac     2100

caacagaaac ctggccaggc tcccaggctc ctcatctatg actcatccaa actggcttct     2160

ggcatcccag ccaggttcag tggcagtggg tctgggacag acttcactct caccatcagc     2220

agcctagagc ctgaagattt tgcagtttat tactgtcagc agtggagtcg taacccaccc     2280

actttcggcg gagggaccaa ggtggagatc aaatcctcca gctaa                     2325


<210>  200
<211>  754
<212>  PRT
<213>  Artificial

<220>
<223>  TSC235 (HD37 x DRA224 scorpion, H75 linker)

<400>  200

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln 
                485                 490                 495     


Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly 
            500                 505                 510         


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
        515                 520                 525             


Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala 
    530                 535                 540                 


Pro Gly Gln Arg Leu Glu Trp Met Gly Tyr Ile Asn Pro Ser Ser Ala 
545                 550                 555                 560 


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Ile Thr Arg 
                565                 570                 575     


Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            580                 585                 590         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Pro Gln Val His Tyr Asp 
        595                 600                 605             


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
                645                 650                 655     


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser 
            660                 665                 670         


Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        675                 680                 685             


Arg Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Ile Pro Ala 
    690                 695                 700                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
705                 710                 715                 720 


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser 
                725                 730                 735     


Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ser 
            740                 745                 750         


Ser Ser 
        


<210>  201
<211>  2295
<212>  DNA
<213>  TSC240  (HD37 x DRA222 scorpion, H81 linker)

<400>  201
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      180

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      240

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggaga aggtggatgc tgcaacctat cactgccagc aaagtactga ggatccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaaggtggcg gtggttcggg cggtggtggg      420

tcgggtggcg gcggagctag ccaggttcag ctgcagcagt ctggggctga gctggtgagg      480

cctgggtcct cagtgaagat ttcctgcaag gcttctggct atgcattcag tagctactgg      540

atgaactggg tgaagcagag gcctggacag ggtcttgagt ggattggaca gatttggcct      600

ggagatggtg atactaacta caatggaaag ttcaagggta aagccactct gactgcagac      660

gaatcctcca gcacagccta catgcaactc agcagcctag catctgagga ctctgcggtc      720

tatttctgtg caagacggga gactacgacg gtaggccgtt attactatgc tatggactac      780

tggggtcaag gaacctcagt caccgtctcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacgc gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggtg aagttcaaat tcccttgacc gaaagttaca gcccgaattc tcaggtccag     1560

ctggtggagt ctgggggcgg agtggtgcag cctgggcggt cactgaggct gtcctgcaag     1620

gcttctggct acacctttac tagatctacg atgcactggg taaggcaggc ccctggacaa     1680

ggtctggaat ggattggata cattaatcct agcagtgctt atactaatta caatcagaaa     1740

ttcaaggaca ggttcacaat cagcgcagac aaatccaaga gcacagcctt cctgcagatg     1800

gacagcctga ggcccgagga caccggcgtc tatttctgtg cacggcccca agtccactat     1860

gattacaacg ggtttcctta ctggggccaa gggactcccg tcactgtctc tagcggtggc     1920

ggagggtctg ggggtggcgg atccggaggt ggtggctctg cacaagacat ccagatgacc     1980

cagtctccaa gcagcctgtc tgcaagcgtg ggggacaggg tcaccatgac ctgcagtgcc     2040

agctcaagtg taagttacat gaactggtac cagcagaagc cgggcaaggc ccccaaaaga     2100

tggatttatg actcatccaa actggcttct ggagtccctg ctcgcttcag tggcagtggg     2160

tctgggaccg actataccct cacaatcagc agcctgcagc ccgaagattt cgccacttat     2220

tactgccagc agtggagtcg taacccaccc acgttcggag gggggaccaa gctacaaatt     2280

acatcctcca gctaa                                                      2295


<210>  202
<211>  744
<212>  PRT
<213>  Artificial

<220>
<223>  TSC240  (HD37 x DRA222 scorpion, H81 linker)

<400>  202

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn 
                485                 490                 495     


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
            500                 505                 510         


Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
        515                 520                 525             


Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    530                 535                 540                 


Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys 
545                 550                 555                 560 


Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala 
                565                 570                 575     


Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe 
            580                 585                 590         


Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp 
        595                 600                 605             


Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr 
625                 630                 635                 640 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met 
                645                 650                 655     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            660                 665                 670         


Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu 
        675                 680                 685             


Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    690                 695                 700                 


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
705                 710                 715                 720 


Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr 
                725                 730                 735     


Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 


<210>  203
<211>  2301
<212>  DNA
<213>  TSC241 (HD37 x DRA222 scorpion, H83 linker)

<400>  203
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      180

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      240

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggaga aggtggatgc tgcaacctat cactgccagc aaagtactga ggatccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaaggtggcg gtggttcggg cggtggtggg      420

tcgggtggcg gcggagctag ccaggttcag ctgcagcagt ctggggctga gctggtgagg      480

cctgggtcct cagtgaagat ttcctgcaag gcttctggct atgcattcag tagctactgg      540

atgaactggg tgaagcagag gcctggacag ggtcttgagt ggattggaca gatttggcct      600

ggagatggtg atactaacta caatggaaag ttcaagggta aagccactct gactgcagac      660

gaatcctcca gcacagccta catgcaactc agcagcctag catctgagga ctctgcggtc      720

tatttctgtg caagacggga gactacgacg gtaggccgtt attactatgc tatggactac      780

tggggtcaag gaacctcagt caccgtctcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacgc gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggtt cttccctgaa tacaggaact cagatggcag gtcattctcc gaattctcag     1560

gtccagctgg tggagtctgg gggcggagtg gtgcagcctg ggcggtcact gaggctgtcc     1620

tgcaaggctt ctggctacac ctttactaga tctacgatgc actgggtaag gcaggcccct     1680

ggacaaggtc tggaatggat tggatacatt aatcctagca gtgcttatac taattacaat     1740

cagaaattca aggacaggtt cacaatcagc gcagacaaat ccaagagcac agccttcctg     1800

cagatggaca gcctgaggcc cgaggacacc ggcgtctatt tctgtgcacg gccccaagtc     1860

cactatgatt acaacgggtt tccttactgg ggccaaggga ctcccgtcac tgtctctagc     1920

ggtggcggag ggtctggggg tggcggatcc ggaggtggtg gctctgcaca agacatccag     1980

atgacccagt ctccaagcag cctgtctgca agcgtggggg acagggtcac catgacctgc     2040

agtgccagct caagtgtaag ttacatgaac tggtaccagc agaagccggg caaggccccc     2100

aaaagatgga tttatgactc atccaaactg gcttctggag tccctgctcg cttcagtggc     2160

agtgggtctg ggaccgacta taccctcaca atcagcagcc tgcagcccga agatttcgcc     2220

acttattact gccagcagtg gagtcgtaac ccacccacgt tcggaggggg gaccaagcta     2280

caaattacat cctccagcta a                                               2301


<210>  204
<211>  746
<212>  PRT
<213>  Artificial

<220>
<223>  TSC241 (HD37 x DRA222 scorpion, H83 linker)

<400>  204

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser 
                485                 490                 495     


Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            500                 505                 510         


Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        515                 520                 525             


Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    530                 535                 540                 


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn 
545                 550                 555                 560 


Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser 
                565                 570                 575     


Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val 
            580                 585                 590         


Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro 
        595                 600                 605             


Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln 
625                 630                 635                 640 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                645                 650                 655     


Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
            660                 665                 670         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser 
        675                 680                 685             


Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    690                 695                 700                 


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
705                 710                 715                 720 


Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
                725                 730                 735     


Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745     


<210>  205
<211>  2313
<212>  DNA
<213>  TSC242 (HD37 x DRA222 scorpion, H91 linker)

<400>  205
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      180

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      240

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggaga aggtggatgc tgcaacctat cactgccagc aaagtactga ggatccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaaggtggcg gtggttcggg cggtggtggg      420

tcgggtggcg gcggagctag ccaggttcag ctgcagcagt ctggggctga gctggtgagg      480

cctgggtcct cagtgaagat ttcctgcaag gcttctggct atgcattcag tagctactgg      540

atgaactggg tgaagcagag gcctggacag ggtcttgagt ggattggaca gatttggcct      600

ggagatggtg atactaacta caatggaaag ttcaagggta aagccactct gactgcagac      660

gaatcctcca gcacagccta catgcaactc agcagcctag catctgagga ctctgcggtc      720

tatttctgtg caagacggga gactacgacg gtaggccgtt attactatgc tatggactac      780

tggggtcaag gaacctcagt caccgtctcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacgc gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggta actcattagc aaaccaagaa gttcaaattc ccttgaccga aagttacagc     1560

ccgaattctc aggtccagct ggtggagtct gggggcggag tggtgcagcc tgggcggtca     1620

ctgaggctgt cctgcaaggc ttctggctac acctttacta gatctacgat gcactgggta     1680

aggcaggccc ctggacaagg tctggaatgg attggataca ttaatcctag cagtgcttat     1740

actaattaca atcagaaatt caaggacagg ttcacaatca gcgcagacaa atccaagagc     1800

acagccttcc tgcagatgga cagcctgagg cccgaggaca ccggcgtcta tttctgtgca     1860

cggccccaag tccactatga ttacaacggg tttccttact ggggccaagg gactcccgtc     1920

actgtctcta gcggtggcgg agggtctggg ggtggcggat ccggaggtgg tggctctgca     1980

caagacatcc agatgaccca gtctccaagc agcctgtctg caagcgtggg ggacagggtc     2040

accatgacct gcagtgccag ctcaagtgta agttacatga actggtacca gcagaagccg     2100

ggcaaggccc ccaaaagatg gatttatgac tcatccaaac tggcttctgg agtccctgct     2160

cgcttcagtg gcagtgggtc tgggaccgac tataccctca caatcagcag cctgcagccc     2220

gaagatttcg ccacttatta ctgccagcag tggagtcgta acccacccac gttcggaggg     2280

gggaccaagc tacaaattac atcctccagc taa                                  2313


<210>  206
<211>  750
<212>  PRT
<213>  Artificial

<220>
<223>  TSC242 (HD37 x DRA222 scorpion, H91 linker)

<400>  206

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr 
                485                 490                 495     


Glu Ser Tyr Ser Pro Asn Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
            500                 505                 510         


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser 
        515                 520                 525             


Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala Pro 
    530                 535                 540                 


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala Tyr 
545                 550                 555                 560 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp 
                565                 570                 575     


Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu 
            580                 585                 590         


Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp Tyr 
        595                 600                 605             


Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
    610                 615                 620                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
625                 630                 635                 640 


Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                645                 650                 655     


Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
            660                 665                 670         


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile 
        675                 680                 685             


Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
    690                 695                 700                 


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
705                 710                 715                 720 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro 
                725                 730                 735     


Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Ser Ser Ser 
            740                 745                 750 


<210>  207
<211>  1815
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC049

<400>  207
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      180

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      240

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggaga aggtggatgc tgcaacctat cactgccagc aaagtactga ggatccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaaggtggcg gtggttcggg cggtggtggg      420

tcgggtggcg gcggagctag ccaggttcag ctgcagcagt ctggggctga gctggtgagg      480

cctgggtcct cagtgaagat ttcctgcaag gcttctggct atgcattcag tagctactgg      540

atgaactggg tgaagcagag gcctggacag ggtcttgagt ggattggaca gatttggcct      600

ggagatggtg atactaacta caatggaaag ttcaagggta aagccactct gactgcagac      660

gaatcctcca gcacagccta catgcaactc agcagcctag catctgagga ctctgcggtc      720

tatttctgtg caagacggga gactacgacg gtaggccgtt attactatgc tatggactac      780

tggggtcaag gaacctcagt caccgtctcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacgc gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggta aatctagagc ctccaccaag ggcccatcgg tcttccccct ggcaccctcc     1560

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc     1620

gagccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg     1680

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc     1740

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg     1800

gacaagaaag tttga                                                      1815


<210>  208
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC049

<400>  208

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys Ser Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
                485                 490                 495     


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
            500                 505                 510         


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
        515                 520                 525             


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
    530                 535                 540                 


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
545                 550                 555                 560 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
                565                 570                 575     


Asn Thr Lys Val Asp Lys Lys Val 
            580                 


<210>  209
<211>  1836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC096

<400>  209
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      180

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      240

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggaga aggtggatgc tgcaacctat cactgccagc aaagtactga ggatccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaaggtggcg gtggttcggg cggtggtggg      420

tcgggtggcg gcggagctag ccaggttcag ctgcagcagt ctggggctga gctggtgagg      480

cctgggtcct cagtgaagat ttcctgcaag gcttctggct atgcattcag tagctactgg      540

atgaactggg tgaagcagag gcctggacag ggtcttgagt ggattggaca gatttggcct      600

ggagatggtg atactaacta caatggaaag ttcaagggta aagccactct gactgcagac      660

gaatcctcca gcacagccta catgcaactc agcagcctag catctgagga ctctgcggtc      720

tatttctgtg caagacggga gactacgacg gtaggccgtt attactatgc tatggactac      780

tggggtcaag gaacctcagt caccgtctcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacgc gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggta aatctagaac tgtggctgca ccatctgtct tcatcttccc gccatctgat     1560

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaattactt ctatcccaga     1620

gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt     1680

gccacagagc aggacagcaa ggacagcacc tacagcctca gcagcgagct gacgctgagc     1740

aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc     1800

tcgcccgtca caaagagctt caacagggga gagtga                               1836


<210>  210
<211>  591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC096

<400>  210

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
                485                 490                 495     


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
            500                 505                 510         


Leu Leu Asn Tyr Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
        515                 520                 525             


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln 
    530                 535                 540                 


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser 
545                 550                 555                 560 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
                565                 570                 575     


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            580                 585                 590     


<210>  211
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC192

<400>  211
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatctag aactgtggct     1500

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct     1560

gttgtgtgcc tgctgaatta cttctatccc agagaggcca aagtacagtg gaaggtggat     1620

aacgccctcc aatcgggtaa ctcccaggag agtgccacag agcaggacag caaggacagc     1680

acctacagcc tcagcagcga gctgacgctg agcaaagcag actacgagaa acacaaagtc     1740

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg     1800

ggagagtga                                                             1809


<210>  212
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC192

<400>  212

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala 
465                 470                 475                 480 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                485                 490                 495     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe Tyr Pro Arg Glu 
            500                 505                 510         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        515                 520                 525             


Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    530                 535                 540                 


Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
545                 550                 555                 560 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                565                 570                 575     


Ser Phe Asn Arg Gly Glu 
            580         


<210>  213
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC193

<400>  213
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctg aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggctaca      480

gtgaagatct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

caacaggccc ctggaaaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cagagaagtt ccagggcaga gtcaccataa ccgcggacac gtctacagac      660

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatctag aactgtggct     1500

gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct     1560

gttgtgtgcc tgctgaatta cttctatccc agagaggcca aagtacagtg gaaggtggat     1620

aacgccctcc aatcgggtaa ctcccaggag agtgccacag agcaggacag caaggacagc     1680

acctacagcc tcagcagcga gctgacgctg agcaaagcag actacgagaa acacaaagtc     1740

tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg     1800

ggagagtga                                                             1809


<210>  214
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC193

<400>  214

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Thr Val Ala 
465                 470                 475                 480 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                485                 490                 495     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe Tyr Pro Arg Glu 
            500                 505                 510         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        515                 520                 525             


Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    530                 535                 540                 


Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
545                 550                 555                 560 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                565                 570                 575     


Ser Phe Asn Arg Gly Glu 
            580         


<210>  215
<211>  1788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC195

<400>  215
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatctag agcctccacc     1500

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg     1560

gccctgggct gcctggtcaa ggactacttc cccgagccgg tgacggtgtc gtggaactca     1620

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac     1680

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc     1740

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagtttga                  1788


<210>  216
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC195

<400>  216

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg Ala Ser Thr 
465                 470                 475                 480 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                485                 490                 495     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            500                 505                 510         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        515                 520                 525             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    530                 535                 540                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
545                 550                 555                 560 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                565                 570                 575 


<210>  217
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC219

<400>  217
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcg       60

cgaggacagg tccagctggt ggagtctggg ggcggagtgg tgcagcctgg gcggtcactg      120

aggctgtcct gcaaggcttc tggctacacc tttactagat ctacgatgca ctgggtaagg      180

caggcccctg gacaaggtct ggaatggatt ggatacatta atcctagcag tgcttatact      240

aattacaatc agaaattcaa ggacaggttc acaatcagcg cagacaaatc caagagcaca      300

gccttcctgc agatggacag cctgaggccc gaggacaccg gcgtctattt ctgtgcacgg      360

ccccaagtcc actatgatta caacgggttt ccttactggg gccaagggac tcccgtcact      420

gtctctagcg gtggcggagg gtctgggggt ggcggatccg gaggtggtgg ctctgcacaa      480

gacatccaga tgacccagtc tccaagcagc ctgtctgcaa gcgtggggga cagggtcacc      540

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagccgggc      600

aaggccccca aaagatggat ttatgactca tccaaactgg cttctggagt ccctgctcgc      660

ttcagtggca gtgggtctgg gaccgactat accctcacaa tcagcagcct gcagcccgaa      720

gatttcgcca cttattactg ccagcagtgg agtcgtaacc cacccacgtt cggagggggg      780

accaagctac aaattacatc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

aaatctagag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc     1560

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgagccggtg     1620

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     1680

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     1740

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa     1800

gtttga                                                                1806


<210>  218
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC219

<400>  218

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser 
465                 470                 475                 480 


Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                485                 490                 495     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            500                 505                 510         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        515                 520                 525             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    530                 535                 540                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
545                 550                 555                 560 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                565                 570                 575     


Lys Lys Val 
            


<210>  219
<211>  1809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC220

<400>  219
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg cttctggata caccttcact agatctacga tgcactgggt gcgccaggcc      180

cccggacaaa ggcttgagtg gatgggatac attaatccta gcagtgctta tactaattac      240

aatcagaaat tcaaggacag agtcaccatt accagggaca catccgcgag cacagcctac      300

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagaccccaa      360

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc      420

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg ggaaagagcc      540

accctctcct gcagtgccag ctcaagtgta agttacatga actggtacca acagaaacct      600

ggccaggctc ccaggctcct catctatgac tcatccaaac tggcttctgg catcccagcc      660

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      720

gaagattttg cagtttatta ctgtcagcag tggagtcgta acccacccac tttcggcgga      780

gggaccaagg tggagatcaa atcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggcgt acgcgtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggtaaatcta gagcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag     1560

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgagccg     1620

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc     1680

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg     1740

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag     1800

aaagtttga                                                             1809


<210>  220
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC220

<400>  220

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys Ser Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
                485                 490                 495     


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            500                 505                 510         


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        515                 520                 525             


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    530                 535                 540                 


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
545                 550                 555                 560 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                565                 570                 575     


Lys Val Asp Lys Lys Val 
            580         


<210>  221
<211>  1827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC222

<400>  221
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcg       60

cgaggacagg tccagctggt ggagtctggg ggcggagtgg tgcagcctgg gcggtcactg      120

aggctgtcct gcaaggcttc tggctacacc tttactagat ctacgatgca ctgggtaagg      180

caggcccctg gacaaggtct ggaatggatt ggatacatta atcctagcag tgcttatact      240

aattacaatc agaaattcaa ggacaggttc acaatcagcg cagacaaatc caagagcaca      300

gccttcctgc agatggacag cctgaggccc gaggacaccg gcgtctattt ctgtgcacgg      360

ccccaagtcc actatgatta caacgggttt ccttactggg gccaagggac tcccgtcact      420

gtctctagcg gtggcggagg gtctgggggt ggcggatccg gaggtggtgg ctctgcacaa      480

gacatccaga tgacccagtc tccaagcagc ctgtctgcaa gcgtggggga cagggtcacc      540

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagccgggc      600

aaggccccca aaagatggat ttatgactca tccaaactgg cttctggagt ccctgctcgc      660

ttcagtggca gtgggtctgg gaccgactat accctcacaa tcagcagcct gcagcccgaa      720

gatttcgcca cttattactg ccagcagtgg agtcgtaacc cacccacgtt cggagggggg      780

accaagctac aaattacatc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

aaatctagaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg     1560

aaatctggaa ctgcctctgt tgtgtgcctg ctgaattact tctatcccag agaggccaaa     1620

gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgccacagag     1680

caggacagca aggacagcac ctacagcctc agcagcgagc tgacgctgag caaagcagac     1740

tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc     1800

acaaagagct tcaacagggg agagtga                                         1827


<210>  222
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC222

<400>  222

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser 
465                 470                 475                 480 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                485                 490                 495     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe 
            500                 505                 510         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        515                 520                 525             


Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser 
    530                 535                 540                 


Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
545                 550                 555                 560 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                565                 570                 575     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            580                 585     


<210>  223
<211>  1830
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC223

<400>  223
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtccagc ttgtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt      120

tcctgcaagg cttctggata caccttcact agatctacga tgcactgggt gcgccaggcc      180

cccggacaaa ggcttgagtg gatgggatac attaatccta gcagtgctta tactaattac      240

aatcagaaat tcaaggacag agtcaccatt accagggaca catccgcgag cacagcctac      300

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagaccccaa      360

gtccactatg attacaacgg gtttccttac tggggccaag gaaccctggt caccgtctcc      420

tcaggtggag gcggttcagg cggaggtgga tccggcggtg gcggatcggg tggcggcgga      480

tctgaaattg tgttgacaca gtctccagcc accctgtctt tgtctccagg ggaaagagcc      540

accctctcct gcagtgccag ctcaagtgta agttacatga actggtacca acagaaacct      600

ggccaggctc ccaggctcct catctatgac tcatccaaac tggcttctgg catcccagcc      660

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      720

gaagattttg cagtttatta ctgtcagcag tggagtcgta acccacccac tttcggcgga      780

gggaccaagg tggagatcaa atcctcgagt gagcccaaat cttctgacaa aactcacaca      840

tgcccaccgt gcccagcacc tgaagccgcg ggtgcaccgt cagtcttcct cttcccccca      900

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      960

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1020

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1080

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggcgt acgcgtgcgc ggtctccaac     1140

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1200

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1260

acctgcctgg tcaaaggctt ctatccaagc gacatcgccg tggagtggga gagcaatggg     1320

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1380

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1440

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1500

ggtaaatcta gaactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag     1560

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaatt acttctatcc cagagaggcc     1620

aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgccaca     1680

gagcaggaca gcaaggacag cacctacagc ctcagcagcg agctgacgct gagcaaagca     1740

gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc     1800

gtcacaaaga gcttcaacag gggagagtga                                      1830


<210>  224
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC223

<400>  224

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ser Ser 
            180                 185                 190         


Lys Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp 
                245                 250                 255     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 
            260                 265                 270         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        275                 280                 285             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    290                 295                 300                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
305                 310                 315                 320 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                325                 330                 335     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            340                 345                 350         


Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    370                 375                 380                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
385                 390                 395                 400 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                405                 410                 415     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        435                 440                 445             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    450                 455                 460                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 475                 480 


Gly Lys Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
                485                 490                 495     


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
            500                 505                 510         


Asn Tyr Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
        515                 520                 525             


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser 
    530                 535                 540                 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala 
545                 550                 555                 560 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
                565                 570                 575     


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            580                 585                 


<210>  225
<211>  1803
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC254

<400>  225
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctg aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggctaca      480

gtgaagatct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

caacaggccc ctggaaaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cagagaagtt ccagggcaga gtcaccataa ccgcggacac gtctacagac      660

acagcctaca tggagctgag cagcctgaga tctgaggaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttcttccct gaatacaccg     1500

aactctgcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc     1560

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga gccggtgacg     1620

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag     1680

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc     1740

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt     1800

tga                                                                   1803


<210>  226
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC254

<400>  226

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser Leu Asn Thr Pro 
465                 470                 475                 480 


Asn Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                485                 490                 495     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            500                 505                 510         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        515                 520                 525             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    530                 535                 540                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
545                 550                 555                 560 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                565                 570                 575     


Asp Lys Lys Val 
            580 


<210>  227
<211>  1845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC258

<400>  227
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcg       60

cgaggacagg tccagctggt ggagtctggg ggcggagtgg tgcagcctgg gcggtcactg      120

aggctgtcct gcaaggcttc tggctacacc tttactagat ctacgatgca ctgggtaagg      180

caggcccctg gacaaggtct ggaatggatt ggatacatta atcctagcag tgcttatact      240

aattacaatc agaaattcaa ggacaggttc acaatcagcg cagacaaatc caagagcaca      300

gccttcctgc agatggacag cctgaggccc gaggacaccg gcgtctattt ctgtgcacgg      360

ccccaagtcc actatgatta caacgggttt ccttactggg gccaagggac tcccgtcact      420

gtctctagcg gtggcggagg gtctgggggt ggcggatccg gaggtggtgg ctctgcacaa      480

gacatccaga tgacccagtc tccaagcagc ctgtctgcaa gcgtggggga cagggtcacc      540

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagccgggc      600

aaggccccca aaagatggat ttatgactca tccaaactgg cttctggagt ccctgctcgc      660

ttcagtggca gtgggtctgg gaccgactat accctcacaa tcagcagcct gcagcccgaa      720

gatttcgcca cttattactg ccagcagtgg agtcgtaacc cacccacgtt cggagggggg      780

accaagctac aaattacatc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

tcttccctga atacaccgaa ctctaggact gtggctgcac catctgtctt catcttcccg     1560

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaattacttc     1620

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc     1680

caggagagtg ccacagagca ggacagcaag gacagcacct acagcctcag cagcgagctg     1740

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag     1800

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtga                     1845


<210>  228
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC258

<400>  228

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Ser 
465                 470                 475                 480 


Leu Asn Thr Pro Asn Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
                485                 490                 495     


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            500                 505                 510         


Cys Leu Leu Asn Tyr Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        515                 520                 525             


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu 
    530                 535                 540                 


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu 
545                 550                 555                 560 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                565                 570                 575     


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            580                 585                 590         


<210>  229
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence from Figure 3


<220>
<221>  misc_feature
<223>  Xaa is a position that was not a consensus in Figure 3 with Ala 
       and Phe being equally prevalent at that position and Val occuring
       in 1 out of 7 of the sequences

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be any naturally occurring amino acid

<400>  229

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Xaa Thr Ile Thr Ala Asp Lys Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  230
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus sequence from Figure 4

<400>  230

Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            20                  25                  30          


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        35                  40                  45              


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr 
            100                 105             


<210>  231
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence from Figure 5


<220>
<221>  misc_feature
<223>  This is the consensus seqeunce from figure 5.  X represents where
       there was no consequence, so X could equally be one of the amino 
       acids shown in that position in the other sequences

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa can be any naturally occurring amino acid

<400>  231

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Xaa Ile Xaa Pro Xaa Xaa Ala Xaa Xaa Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Xaa Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Xaa Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  232
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKV1-5*01

<400>  232

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser 
                85                  90                  95  


<210>  233
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence from Figure 6


<220>
<221>  misc_feature
<223>  This is the consensus seqeunce from figure 6.  X represents where
       there was no consequence, so X could equally be one of the amino 
       acids shown in that position in the other sequences

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<400>  233

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Xaa Ala Ser Xaa Ser Ile Ser Xaa Trp 
            20                  25                  30          


Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Xaa Xaa Ile 
        35                  40                  45              


Tyr Asp Ala Ser Xaa Leu Xaa Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp 
                85                  90      


<210>  234
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKJ1*01

<400>  234

Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  235
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKJ2*01

<400>  235

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210>  236
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   IGKJ3*01

<400>  236

Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
1               5                   10          


<210>  237
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKJ4*01

<400>  237

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


<210>  238
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGKJ5*01

<400>  238

Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10          


<210>  239
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   Figure 7 consensus sequence

<400>  239

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys 
            340                 345                 350         


Ala Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys 
            420             


<210>  240
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRA161

<400>  240

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Arg Arg Thr Ser Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  241
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of Figure 8

<400>  241

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Ala Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  242
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC125

<400>  242
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

caggtccagc tggtgcagtc tgggggcgga gtggtgcagc ctgggcggtc actgaggctg      120

tcctgcaagg cttctggcta cacctttact agatctacga tgcactgggt aaggcaggcc      180

cctggaaagg gtctggaatg gattggatac attaatccta gcagtgctta tactaattac      240

aatcagaaat tcaaggacag gttcacaatc agcgcagaca aatccaagag cacagccttc      300

ctgcagatgg acagcctgag gcccgaggac accggcgtct atttctgtgc acggccccaa      360

gtccactatg attacaacgg gtttccttac tggggccaag ggactcccgt cactgtctct      420

agcggtggcg gagggtctgg gggtggcgga tccggaggtg gtggctctgc acaagacatc      480

cagatgaccc agtctccaag cagcctgtct gcaagcgtgg gggacagggt caccatgacc      540

tgcagtgcca gctcaagtgt aagttacatg aactggtacc agcagaagcc cggcaaggcc      600

cccaaaagat ggatttatga ctcatccaaa ctggcttctg gagtccctgc tcgcttcagt      660

ggcagtgggt ctgggaccga ctataccctc acaatcagca gcctgcagcc cgaagatttc      720

gccacttatt actgccagca gtggagtcgt aacccaccca cgttcggagg ggggaccaag      780

ctacaaatta cacgctcgag tgagcccaaa tcttctgaca aaactcacac atgcccaccg      840

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggcg tacgcgtgcg cggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatct     1500

agagcctcca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct     1560

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgagcc ggtgacggtg     1620

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc     1680

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag     1740

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagtttga     1800


<210>  243
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC125 mature protein

<400>  243

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Gln Ile Thr Arg Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser 
465                 470                 475                 480 


Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                485                 490                 495     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            500                 505                 510         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        515                 520                 525             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    530                 535                 540                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
545                 550                 555                 560 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                565                 570                 575     


Lys Lys Val 
            


<210>  244
<211>  2310
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC129a DNA

<400>  244
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      120

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttattt gaactggtac      180

caacagattc caggacagcc acccaaactc ctcatctatg atgcatccaa tctagtttct      240

gggatcccac ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      300

cctgtggaga aggtggatgc tgcaacctat cactgccagc aaagtactga ggatccgtgg      360

acgttcggtg gaggcaccaa gctggaaatc aaaggtggcg gtggttcggg cggtggtggg      420

tcgggtggcg gcggagctag ccaggttcag ctgcagcagt ctggggctga gctggtgagg      480

cctgggtcct cagtgaagat ttcctgcaag gcttctggct atgcattcag tagctactgg      540

atgaactggg tgaagcagag gcctggacag ggtcttgagt ggattggaca gatttggcct      600

ggagatggtg atactaacta caatggaaag ttcaagggta aagccactct gactgcagac      660

gaatcctcca gcacagccta catgcaactc agcagcctag catctgagga ctctgcggtc      720

tatttctgtg caagacggga gactacgacg gtaggccgtt attactatgc tatggactac      780

tggggtcaag gaacctcagt caccgtctcc tcgagtgagc ccaaatcttc tgacaaaact      840

cacacatgcc caccgtgccc agcacctgaa gccgcgggtg caccgtcagt cttcctcttc      900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggcgtacgc gtgcgcggtc     1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1260

agcctgacct gcctggtcaa aggcttctat ccaagcgaca tcgccgtgga gtgggagagc     1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1500

tctccgggtc agaggcacaa caattcttcc ctgaatacag gaactcagat ggcaggtcat     1560

tctccgaatt ctcaggtcca gctggtgcag tctgggggcg gagtggtgca gcctgggcgg     1620

tcactgaggc tgtcctgcaa ggcttctggc tacaccttta ctagatctac gatgcactgg     1680

gtaaggcagg cccctggaaa gggtctggaa tggattggat acattaatcc tagcagtgct     1740

tatactaatt acaatcagaa attcaaggac aggttcacaa tcagcgcaga caaatccaag     1800

agcacagcct tcctgcagat ggacagcctg aggcccgagg acaccggcgt ctatttctgt     1860

gcacggcccc aagtccacta tgattacaac gggtttcctt actggggcca agggactccc     1920

gtcactgtct ctagcggtgg cggagggtct gggggtggcg gatccggagg tggtggctct     1980

gcacaagaca tccagatgac ccagtctcca agcagcctgt ctgcaagcgt gggggacagg     2040

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgaactggta ccagcagaag     2100

cccggcaagg cccccaaaag atggatttat gactcatcca aactggcttc tggagtccct     2160

gctcgcttca gtggcagtgg gtctgggacc gactataccc tcacaatcag cagcctgcag     2220

cccgaagatt tcgccactta ttactgccag cagtggagtc gtaacccacc cacgttcgga     2280

ggggggacca agctacaaat tacacgataa                                      2310


<210>  245
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC129a mature protein

<400>  245

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser 
    130                 135                 140                 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Glu Pro Lys Ser 
                245                 250                 255     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
            260                 265                 270         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln 
                485                 490                 495     


Met Ala Gly His Ser Pro Asn Ser Gln Val Gln Leu Val Gln Ser Gly 
            500                 505                 510         


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
        515                 520                 525             


Ser Gly Tyr Thr Phe Thr Arg Ser Thr Met His Trp Val Arg Gln Ala 
    530                 535                 540                 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Ser Ala 
545                 550                 555                 560 


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Ala 
                565                 570                 575     


Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
            580                 585                 590         


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Pro Gln Val His Tyr Asp 
        595                 600                 605             


Tyr Asn Gly Phe Pro Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Ala Gln Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                645                 650                 655     


Val Gly Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser 
            660                 665                 670         


Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp 
        675                 680                 685             


Ile Tyr Asp Ser Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    690                 695                 700                 


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
705                 710                 715                 720 


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Asn Pro 
                725                 730                 735     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Thr Arg 
            740                 745                 


<210>  246
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC218 DNA

<400>  246
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcg       60

cgaggacagg tccagctggt ggagtctggg ggcggagtgg tgcagcctgg gcggtcactg      120

aggctgtcct gcaaggcttc tggctacacc tttactagat ctacgatgca ctgggtaagg      180

caggcccctg gacaaggtct ggaatggatt ggatacatta atcctagcag tgcttatact      240

aattacaatc agaaattcaa ggacaggttc acaatcagcg cagacaaatc caagagcaca      300

gccttcctgc agatggacag cctgaggccc gaggacaccg gcgtctattt ctgtgcacgg      360

ccccaagtcc actatgatta caacgggttt ccttactggg gccaagggac tcccgtcact      420

gtctctagcg gtggcggagg gtctgggggt ggcggatccg gaggtggtgg ctctgcacaa      480

gacatccaga tgacccagtc tccaagcagc ctgtctgcaa gcgtggggga cagggtcacc      540

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagccgggc      600

aaggccccca aactcctcat ttatgactca tccaaactgg cttctggagt ccctgctcgc      660

ttcagtggca gtgggtctgg gaccgactat accctcacaa tcagcagcct gcagcccgaa      720

gatttcgcca cttattactg ccagcagtgg agtcgtaacc cacccacttt cggcggaggg      780

accaaggtgg agatcaaatc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

aaatctagag cctccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc     1560

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgagccggtg     1620

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta     1680

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc     1740

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa     1800

gtttga                                                                1806


<210>  247
<211>  579
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC218 mature protein

<400>  247

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser 
465                 470                 475                 480 


Arg Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
                485                 490                 495     


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
            500                 505                 510         


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        515                 520                 525             


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    530                 535                 540                 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
545                 550                 555                 560 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                565                 570                 575     


Lys Lys Val 
            


<210>  248
<211>  1827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC221 DNA

<400>  248
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcg       60

cgaggacagg tccagctggt ggagtctggg ggcggagtgg tgcagcctgg gcggtcactg      120

aggctgtcct gcaaggcttc tggctacacc tttactagat ctacgatgca ctgggtaagg      180

caggcccctg gacaaggtct ggaatggatt ggatacatta atcctagcag tgcttatact      240

aattacaatc agaaattcaa ggacaggttc acaatcagcg cagacaaatc caagagcaca      300

gccttcctgc agatggacag cctgaggccc gaggacaccg gcgtctattt ctgtgcacgg      360

ccccaagtcc actatgatta caacgggttt ccttactggg gccaagggac tcccgtcact      420

gtctctagcg gtggcggagg gtctgggggt ggcggatccg gaggtggtgg ctctgcacaa      480

gacatccaga tgacccagtc tccaagcagc ctgtctgcaa gcgtggggga cagggtcacc      540

atgacctgca gtgccagctc aagtgtaagt tacatgaact ggtaccagca gaagccgggc      600

aaggccccca aactcctcat ttatgactca tccaaactgg cttctggagt ccctgctcgc      660

ttcagtggca gtgggtctgg gaccgactat accctcacaa tcagcagcct gcagcccgaa      720

gatttcgcca cttattactg ccagcagtgg agtcgtaacc cacccacttt cggcggaggg      780

accaaggtgg agatcaaatc ctcgagtgag cccaaatctt ctgacaaaac tcacacatgc      840

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      900

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      960

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1020

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1080

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1140

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1200

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1260

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1320

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1380

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1500

aaatctagaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg     1560

aaatctggaa ctgcctctgt tgtgtgcctg ctgaattact tctatcccag agaggccaaa     1620

gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgccacagag     1680

caggacagca aggacagcac ctacagcctc agcagcgagc tgacgctgag caaagcagac     1740

tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc     1800

acaaagagct tcaacagggg agagtga                                         1827


<210>  249
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC221 mature protein

<400>  249

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ser Ser Lys Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala 
            340                 345                 350         


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser 
465                 470                 475                 480 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                485                 490                 495     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe 
            500                 505                 510         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        515                 520                 525             


Ser Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser 
    530                 535                 540                 


Thr Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
545                 550                 555                 560 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                565                 570                 575     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            580                 585     


<210>  250
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TSC194 DNA

<400>  250
atggaagcac cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccggt       60

gatatccaga tgacccagtc tccatccgcc atgtctgcat ctgtaggaga cagagtcacc      120

atcacttgcc gggcgagtaa gagcattagc aaatatttag cctggtttca gcagaaacca      180

gggaaagttc ctaagctccg catccattct ggatctactt tgcaatcagg ggtcccatct      240

cggttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtcaacag catattgaat acccgtggac gttcggccaa      360

gggaccaagg tggaaatcaa acgaggtggc ggagggtctg ggggtggcgg atccggaggt      420

ggtggctctc aggtccagct ggtacagtct ggggctgagg tgaagaagcc tggggcttca      480

gtgaaggtct cctgcaaggc ttctggatac acattcactg actactacat gcactgggtg      540

cgacaggccc ctggacaagg gcttgagtgg atgggatatt ttaatcctta taatgattat      600

actagatacg cacagaagtt ccagggcaga gtcaccatga ccagggacac gtctatcagc      660

acagcctaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca      720

agatcggatg gttactacga tgctatggac tactggggtc aaggaaccac agtcaccgtc      780

tcctcgagtg agcccaaatc ttctgacaaa actcacacat gcccaccgtg cccagcacct      840

gaagccgcgg gtgcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      900

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      960

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1020

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1080

tggctgaatg gcaaggcgta cgcgtgcgcg gtctccaaca aagccctccc agcccccatc     1140

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1200

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1260

tatccaagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1320

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1380

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1440

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtcagaggca caacaattct     1500

tccctgaata caggaactca gatggcaggt cattctccga attctcaggt ccagctggtg     1560

cagtctgggg gcggagtggt gcagcctggg cggtcactga ggctgtcctg caaggcttct     1620

ggctacacct ttactagatc tacgatgcac tgggtaaggc aggcccctgg aaagggtctg     1680

gaatggattg gatacattaa tcctagcagt gcttatacta attacaatca gaaattcaag     1740

gacaggttca caatcagcgc agacaaatcc aagagcacag ccttcctgca gatggacagc     1800

ctgaggcccg aggacaccgg cgtctatttc tgtgcacggc cccaagtcca ctatgattac     1860

aacgggtttc cttactgggg ccaagggact cccgtcactg tctctagcgg tggcggaggg     1920

tctgggggtg gcggatccgg aggtggtggc tctgcacaag acatccagat gacccagtct     1980

ccaagcagcc tgtctgcaag cgtgggggac agggtcacca tgacctgcag tgccagctca     2040

agtgtaagtt acatgaactg gtaccagcag aagcccggca aggcccccaa aagatggatt     2100

tatgactcat ccaaactggc ttctggagtc cctgctcgct tcagtggcag tgggtctggg     2160

accgactata ccctcacaat cagcagcctg cagcccgaag atttcgccac ttattactgc     2220

cagcagtgga gtcgtaaccc acccacgttc ggagggggga ccaagctaca aattacacga     2280

taa                                                                   2283


<210>  251
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TSC194  mature protein

<400>  251

Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Arg Ile 
        35                  40                  45              


His Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Ile Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
        115                 120                 125             


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
    130                 135                 140                 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Phe Asn Pro 
                165                 170                 175     


Tyr Asn Asp Tyr Thr Arg Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
            180                 185                 190         


Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205             


Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Asp Gly 
    210                 215                 220                 


Tyr Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
465                 470                 475                 480 


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Gln 
                485                 490                 495     


Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
            500                 505                 510         


Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ser Thr 
        515                 520                 525             


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
    530                 535                 540                 


Tyr Ile Asn Pro Ser Ser Ala Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
545                 550                 555                 560 


Asp Arg Phe Thr Ile Ser Ala Asp Lys Ser Lys Ser Thr Ala Phe Leu 
                565                 570                 575     


Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala 
            580                 585                 590         


Arg Pro Gln Val His Tyr Asp Tyr Asn Gly Phe Pro Tyr Trp Gly Gln 
        595                 600                 605             


Gly Thr Pro Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Ala Gln Asp Ile Gln Met Thr Gln Ser 
625                 630                 635                 640 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Met Thr Cys 
                645                 650                 655     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
            660                 665                 670         


Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Ser Ser Lys Leu Ala Ser 
        675                 680                 685             


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
    690                 695                 700                 


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
705                 710                 715                 720 


Gln Gln Trp Ser Arg Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
                725                 730                 735     


Gln Ile Thr Arg 
            740 


<210>  252
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  252

Leu Gln Ile Thr 
1               


<210>  253
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VEIK

<400>  253

Val Glu Ile Lys 
1               


<210>  254
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  254

Val Glu Pro Lys Ser Cys 
1               5       


<210>  255
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  255

Phe Asn Arg Gly Glu Cys 
1               5       


