                         SEQUENCE LISTING

<110>  IMBA - INSTITUT FR MOLEKULARE BIOTECHNOLOGIE GMBH
 
<120>  Archease as ligase complex member

<130>  r63627

<150>  EP 12165153.3
<151>  2012-04-23

<160>  48    

<170>  PatentIn version 3.3

<210>  1
<211>  505
<212>  PRT
<213>  H.sapiens

<400>  1

Met Ser Arg Ser Tyr Asn Asp Glu Leu Gln Phe Leu Glu Lys Ile Asn 
1               5                   10                  15      


Lys Asn Cys Trp Arg Ile Lys Lys Gly Phe Val Pro Asn Met Gln Val 
            20                  25                  30          


Glu Gly Val Phe Tyr Val Asn Asp Ala Leu Glu Lys Leu Met Phe Glu 
        35                  40                  45              


Glu Leu Arg Asn Ala Cys Arg Gly Gly Gly Val Gly Gly Phe Leu Pro 
    50                  55                  60                  


Ala Met Lys Gln Ile Gly Asn Val Ala Ala Leu Pro Gly Ile Val His 
65                  70                  75                  80  


Arg Ser Ile Gly Leu Pro Asp Val His Ser Gly Tyr Gly Phe Ala Ile 
                85                  90                  95      


Gly Asn Met Ala Ala Phe Asp Met Asn Asp Pro Glu Ala Val Val Ser 
            100                 105                 110         


Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu Arg 
        115                 120                 125             


Thr Asn Leu Asp Glu Ser Asp Val Gln Pro Val Lys Glu Gln Leu Ala 
    130                 135                 140                 


Gln Ala Met Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly Val 
145                 150                 155                 160 


Ile Pro Met Asn Ala Lys Asp Leu Glu Glu Ala Leu Glu Met Gly Val 
                165                 170                 175     


Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp Lys Glu His 
            180                 185                 190         


Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Pro Asn Lys Val Ser 
        195                 200                 205             


Ala Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly Ala 
    210                 215                 220                 


Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile Phe Asn Glu 
225                 230                 235                 240 


Tyr Ala Ala Lys Lys Met Gly Ile Asp His Lys Gly Gln Val Cys Val 
                245                 250                 255     


Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val Ala Thr Asp 
            260                 265                 270         


Ala Leu Val Ala Met Glu Lys Ala Met Lys Arg Asp Lys Ile Ile Val 
        275                 280                 285             


Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Ala Ser Pro Glu Gly Gln 
    290                 295                 300                 


Asp Tyr Leu Lys Gly Met Ala Ala Ala Gly Asn Tyr Ala Trp Val Asn 
305                 310                 315                 320 


Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ala Lys Val Phe 
                325                 330                 335     


Asn Thr Thr Pro Asp Asp Phe Asp Leu His Val Ile Tyr Asp Val Ser 
            340                 345                 350         


His Asn Ile Ala Lys Val Glu Gln His Val Val Asp Gly Lys Glu Arg 
        355                 360                 365             


Thr Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe Pro Pro His 
    370                 375                 380                 


His Pro Leu Ile Ala Val Asp Tyr Gln Leu Thr Gly Gln Pro Val Leu 
385                 390                 395                 400 


Ile Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr Glu 
                405                 410                 415     


Gln Gly Met Thr Glu Thr Phe Gly Thr Thr Cys His Gly Ala Gly Arg 
            420                 425                 430         


Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Phe Gln Asp Val 
        435                 440                 445             


Leu Asp Lys Leu Ala Asp Met Gly Ile Ala Ile Arg Val Ala Ser Pro 
    450                 455                 460                 


Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asn Val Thr Asp 
465                 470                 475                 480 


Val Val Asn Thr Cys His Asp Ala Gly Ile Ser Lys Lys Ala Ile Lys 
                485                 490                 495     


Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505 


<210>  2
<211>  505
<212>  PRT
<213>  M.musculus

<400>  2

Met Ser Arg Asn Tyr Asn Asp Glu Leu Gln Phe Leu Asp Lys Ile Asn 
1               5                   10                  15      


Lys Asn Cys Trp Arg Ile Lys Lys Gly Phe Val Pro Asn Met Gln Val 
            20                  25                  30          


Glu Gly Val Phe Tyr Val Asn Asp Ala Leu Glu Lys Leu Met Phe Glu 
        35                  40                  45              


Glu Leu Arg Asn Ala Cys Arg Gly Gly Gly Val Gly Gly Phe Leu Pro 
    50                  55                  60                  


Ala Met Lys Gln Ile Gly Asn Val Ala Ala Leu Pro Gly Ile Val His 
65                  70                  75                  80  


Arg Ser Ile Gly Leu Pro Asp Val His Ser Gly Tyr Gly Phe Ala Ile 
                85                  90                  95      


Gly Asn Met Ala Ala Phe Asp Met Asn Asp Pro Glu Ala Val Val Ser 
            100                 105                 110         


Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu Arg 
        115                 120                 125             


Thr Asn Leu Asp Glu Ser Asp Val Gln Pro Val Lys Glu Gln Leu Ala 
    130                 135                 140                 


Gln Ala Met Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly Val 
145                 150                 155                 160 


Ile Pro Met Asn Ala Lys Asp Leu Glu Glu Ala Leu Glu Met Gly Val 
                165                 170                 175     


Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp Lys Glu His 
            180                 185                 190         


Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Pro Asn Lys Val Ser 
        195                 200                 205             


Pro Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly Ala 
    210                 215                 220                 


Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile Phe Asn Glu 
225                 230                 235                 240 


Tyr Ala Ala Lys Lys Met Gly Ile Asp His Lys Gly Gln Val Cys Val 
                245                 250                 255     


Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val Ala Thr Asp 
            260                 265                 270         


Ala Leu Val Ala Met Glu Lys Ala Met Lys Arg Asp Lys Ile Ile Val 
        275                 280                 285             


Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Ala Ser Pro Glu Gly Gln 
    290                 295                 300                 


Asp Tyr Leu Lys Gly Met Ala Ala Ala Gly Asn Tyr Ala Trp Val Asn 
305                 310                 315                 320 


Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ala Lys Val Phe 
                325                 330                 335     


Asn Thr Thr Pro Asp Asp Leu Asp Leu His Val Ile Tyr Asp Val Ser 
            340                 345                 350         


His Asn Ile Ala Lys Val Glu Gln His Val Val Asp Gly Lys Glu Arg 
        355                 360                 365             


Thr Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe Pro Pro His 
    370                 375                 380                 


His Pro Leu Ile Ala Val Asp Tyr Gln Leu Thr Gly Gln Pro Val Leu 
385                 390                 395                 400 


Ile Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr Glu 
                405                 410                 415     


Gln Gly Met Thr Glu Thr Phe Gly Thr Thr Cys His Gly Ala Gly Arg 
            420                 425                 430         


Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Phe Gln Asp Val 
        435                 440                 445             


Leu Asp Lys Leu Ala Asp Met Gly Ile Ala Ile Arg Val Ala Ser Pro 
    450                 455                 460                 


Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asn Val Thr Asp 
465                 470                 475                 480 


Val Val Asn Thr Cys His Asp Ala Gly Ile Ser Lys Lys Ala Ile Lys 
                485                 490                 495     


Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505 


<210>  3
<211>  505
<212>  PRT
<213>  X.leavis

<400>  3

Met Ser Arg Ser Tyr Asn Asp Glu Leu Gln Tyr Leu Asp Lys Ile His 
1               5                   10                  15      


Asn Asn Cys Trp Arg Ile Arg Lys Gly Phe Val Pro Asn Met Gln Val 
            20                  25                  30          


Glu Gly Val Phe Tyr Val Asn Asp Pro Leu Glu Lys Leu Met Phe Glu 
        35                  40                  45              


Glu Leu Arg Asn Ala Ser Arg Gly Gly Ala Ala Gly Gly Phe Leu Pro 
    50                  55                  60                  


Ala Met Lys Gln Ile Gly Asn Val Ala Ala Leu Pro Gly Ile Val His 
65                  70                  75                  80  


Arg Ser Ile Gly Leu Pro Asp Val His Ser Gly Tyr Gly Phe Ala Ile 
                85                  90                  95      


Gly Asn Met Ala Ala Phe Asp Met Glu Asn Pro Asp Ala Val Val Ser 
            100                 105                 110         


Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu Arg 
        115                 120                 125             


Thr Asn Leu Asp Glu Ser Asp Val Gln Pro Val Lys Glu Gln Leu Ala 
    130                 135                 140                 


Gln Ser Met Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly Val 
145                 150                 155                 160 


Ile Pro Met Gly Ala Lys Asp Leu Glu Glu Ala Leu Glu Met Gly Val 
                165                 170                 175     


Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp Lys Glu His 
            180                 185                 190         


Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Pro Ser Lys Val Ser 
        195                 200                 205             


Ser Lys Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly Ala 
    210                 215                 220                 


Gly Asn His Tyr Ala Glu Val Gln Val Val Asp Glu Ile Tyr Asp Glu 
225                 230                 235                 240 


Tyr Ala Ala Lys Lys Met Gly Ile Asp His Lys Gly Gln Val Cys Val 
                245                 250                 255     


Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val Ala Thr Asp 
            260                 265                 270         


Ala Leu Val Ala Met Glu Lys Ala Met Lys Arg Asp Lys Ile Thr Val 
        275                 280                 285             


Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Ser Ser Asp Glu Gly Gln 
    290                 295                 300                 


Asp Tyr Leu Lys Gly Met Ala Ala Ala Gly Asn Tyr Ala Trp Val Asn 
305                 310                 315                 320 


Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ser Lys Val Phe 
                325                 330                 335     


Asn Thr Pro Pro Asp Asp Leu Asp Met His Val Ile Tyr Asp Val Ser 
            340                 345                 350         


His Asn Ile Ala Lys Val Glu Gln His Val Val Glu Gly Lys Glu Met 
        355                 360                 365             


Thr Leu Leu Val His Arg Lys Gly Ala Thr Arg Ala Phe Pro Pro His 
    370                 375                 380                 


His Pro Leu Ile Pro Val Asp Tyr Gln Leu Thr Gly Gln Pro Val Leu 
385                 390                 395                 400 


Ile Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr Asp 
                405                 410                 415     


Gln Gly Met Thr Glu Thr Phe Gly Thr Thr Cys His Gly Ala Gly Arg 
            420                 425                 430         


Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Phe Gln Asp Val 
        435                 440                 445             


Leu Asp Lys Leu Ala Asp Leu Gly Ile Ala Ile Arg Val Ala Ser Pro 
    450                 455                 460                 


Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asn Val Thr Asp 
465                 470                 475                 480 


Val Val Asn Thr Cys His Asp Ala Gly Ile Ser Lys Lys Ala Ile Lys 
                485                 490                 495     


Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505 


<210>  4
<211>  508
<212>  PRT
<213>  S.purpuratus

<400>  4

Met Ala Ala Thr Val Arg Glu Tyr Lys Glu Glu Leu Lys Tyr Leu Asn 
1               5                   10                  15      


Lys Leu Ser Asp Asn Cys Trp Gln Ile Lys Lys Gly Phe Val Asp Asn 
            20                  25                  30          


Met Lys Val Glu Gly Arg Phe Tyr Val Asp Ser Lys Leu Glu Lys Leu 
        35                  40                  45              


Met Phe Glu Glu Leu Gln Gln Ala Cys Arg Ser Lys Gly Val Gly Gly 
    50                  55                  60                  


Phe Leu Pro Ala Val Lys Gln Ile Ala Asn Val Ala Ala Leu Pro Gly 
65                  70                  75                  80  


Ile Thr Gly Tyr Ser Ile Gly Leu Pro Asp Ile His Ser Gly Tyr Gly 
                85                  90                  95      


Phe Ala Ile Gly Asn Met Ala Ala Phe Asp Met Ser Asn Pro Glu Ala 
            100                 105                 110         


Val Val Ser Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg 
        115                 120                 125             


Leu Leu Arg Thr Asn Leu Thr Glu Lys Asp Val Lys Pro Val Lys Glu 
    130                 135                 140                 


Gln Leu Ala Gln Ser Leu Phe Asp His Ile Pro Val Gly Val Gly Ser 
145                 150                 155                 160 


Lys Gly Val Ile Pro Met Gly Ala Lys Glu Leu Glu Glu Ala Leu Glu 
                165                 170                 175     


Met Gly Met Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp 
            180                 185                 190         


Lys Glu His Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Pro Asn 
        195                 200                 205             


Lys Val Ser Ala Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr 
    210                 215                 220                 


Leu Gly Ala Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile 
225                 230                 235                 240 


Tyr Asn Asp His Ala Ala Lys Lys Met Gly Ile Asp Arg Lys Gly Gln 
                245                 250                 255     


Val Cys Leu Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val 
            260                 265                 270         


Ala Thr Asp Ala Leu Val Gln Met Glu Lys Ala Met Lys Arg Asp Lys 
        275                 280                 285             


Ile Glu Val Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile His Ser Gln 
    290                 295                 300                 


Glu Gly Gln Asp Tyr Leu Lys Ala Met Ala Ala Ala Ala Asn Tyr Ala 
305                 310                 315                 320 


Trp Val Asn Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ala 
                325                 330                 335     


Lys Gln Phe Asp Thr Thr Pro Asp Asp Leu Asp Met His Val Ile Tyr 
            340                 345                 350         


Asp Val Ser His Asn Ile Ala Lys Val Glu Glu His Met Val Asp Gly 
        355                 360                 365             


Val Gln Lys Thr Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe 
    370                 375                 380                 


Pro Pro His His Pro Leu Ile Pro Val Asp Tyr Gln Met Thr Gly Gln 
385                 390                 395                 400 


Pro Val Leu Ile Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr 
                405                 410                 415     


Gly Thr Glu Ser Gly Met Ala Thr Thr Tyr Gly Thr Thr Cys His Gly 
            420                 425                 430         


Ala Gly Arg Ala Trp Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Tyr 
        435                 440                 445             


Gln Thr Val Leu Lys Asn Leu His Glu Leu Gly Ile Ser Ile Arg Val 
    450                 455                 460                 


Ala Ser Pro Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asp 
465                 470                 475                 480 


Val Thr Ser Val Val Asn Thr Cys His Asp Val Gly Ile Ser Lys Lys 
                485                 490                 495     


Val Leu Lys Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505             


<210>  5
<211>  506
<212>  PRT
<213>  D.melanogaster

<400>  5

Met Val Val Arg Pro Tyr Asn Asp Glu Leu Arg Tyr Leu Glu Lys Val 
1               5                   10                  15      


Ser Asp His Cys Trp Arg Ile Lys Lys Gly Phe Gln Pro Asn Met Asn 
            20                  25                  30          


Val Glu Gly Cys Phe Tyr Val Asn Ser Arg Leu Glu Arg Leu Met Leu 
        35                  40                  45              


Glu Glu Leu Lys Asn Ser Cys Arg Pro Gly Ala Val Gly Gly Phe Leu 
    50                  55                  60                  


Pro Gly Val Lys Gln Ile Ala Asn Val Ala Ala Leu Pro Gly Ile Val 
65                  70                  75                  80  


Gly Arg Ser Ile Gly Leu Pro Asp Ile His Ser Gly Tyr Gly Phe Ala 
                85                  90                  95      


Ile Gly Asn Met Ala Ala Phe Asp Met Asn Asp Pro Leu Ser Val Val 
            100                 105                 110         


Ser Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu 
        115                 120                 125             


Arg Thr Asn Leu Tyr Glu Lys Asp Val Gln Pro Val Lys Glu Gln Leu 
    130                 135                 140                 


Ala Gln Ser Leu Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly 
145                 150                 155                 160 


Ile Ile Pro Met Asn Ala Arg Asp Leu Glu Glu Ala Leu Glu Met Gly 
                165                 170                 175     


Met Asp Trp Ser Leu Arg Glu Gly Tyr Val Trp Ala Glu Asp Lys Glu 
            180                 185                 190         


His Cys Glu Glu Tyr Gly Arg Met Leu Asn Ala Asp Pro Ala Lys Val 
        195                 200                 205             


Ser Met Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly 
    210                 215                 220                 


Ala Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile Tyr Asp 
225                 230                 235                 240 


Lys Trp Ser Ala Ser Lys Met Gly Ile Glu Glu Lys Gly Gln Val Val 
                245                 250                 255     


Val Met Ile His Ser Gly Ser Arg Gly Phe Gly His Gln Val Ala Thr 
            260                 265                 270         


Asp Ala Leu Val Gln Met Glu Lys Ala Met Lys Arg Asp Lys Ile Glu 
        275                 280                 285             


Thr Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Asn Ser Val Glu Gly 
    290                 295                 300                 


Gln Asp Tyr Leu Lys Ala Met Ala Ala Ala Ala Asn Phe Ala Trp Val 
305                 310                 315                 320 


Asn Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ala Lys Met 
                325                 330                 335     


Phe Asn Thr Thr Pro Asp Asp Leu Asp Met His Val Ile Tyr Asp Val 
            340                 345                 350         


Ser His Asn Ile Ala Lys Val Glu Asn His Met Val Asp Gly Lys Glu 
        355                 360                 365             


Arg Lys Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe Pro Pro 
    370                 375                 380                 


His His Pro Leu Ile Pro Val Asp Tyr Gln Leu Thr Gly Gln Pro Val 
385                 390                 395                 400 


Leu Val Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr 
                405                 410                 415     


Glu Gln Gly Met Gln Glu Thr Phe Gly Ser Thr Cys His Gly Ala Gly 
            420                 425                 430         


Arg Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Tyr Lys Asp 
        435                 440                 445             


Val Leu Asp Lys Leu Asp Gln Leu Gly Ile Ala Ile Arg Val Ala Ser 
    450                 455                 460                 


Pro Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asp Val Thr 
465                 470                 475                 480 


Asp Val Val Asp Thr Cys His Ala Ala Gly Ile Ser Lys Lys Cys Ile 
                485                 490                 495     


Lys Met Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505     


<210>  6
<211>  505
<212>  PRT
<213>  C.elegans

<400>  6

Met Pro Arg Thr Phe Glu Glu Glu Cys Asp Phe Ile Asp Arg Leu Thr 
1               5                   10                  15      


Asp Thr Lys Phe Arg Ile Lys Lys Gly Phe Val Pro Asn Met Asn Val 
            20                  25                  30          


Glu Gly Arg Phe Tyr Val Asn Asn Ser Leu Glu Gln Leu Met Phe Asp 
        35                  40                  45              


Glu Leu Lys Phe Ser Cys Asp Gly Gln Gly Ile Gly Gly Phe Leu Pro 
    50                  55                  60                  


Ala Val Arg Gln Ile Ala Asn Val Ala Ser Leu Pro Gly Ile Val Gly 
65                  70                  75                  80  


His Ser Ile Gly Leu Pro Asp Ile His Ser Gly Tyr Gly Phe Ser Ile 
                85                  90                  95      


Gly Asn Ile Ala Ala Phe Asp Val Gly Asn Pro Glu Ser Val Ile Ser 
            100                 105                 110         


Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu Arg 
        115                 120                 125             


Thr Asn Leu Phe Glu Glu Asn Val Lys Pro Leu Lys Glu Gln Leu Thr 
    130                 135                 140                 


Gln Ser Leu Phe Asp His Ile Pro Val Gly Val Gly Ser Arg Gly Ala 
145                 150                 155                 160 


Ile Pro Met Leu Ala Ser Asp Leu Val Glu Cys Leu Glu Met Gly Met 
                165                 170                 175     


Asp Trp Thr Leu Arg Glu Gly Tyr Ser Trp Ala Glu Asp Lys Glu His 
            180                 185                 190         


Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Ala Ser Lys Val Ser 
        195                 200                 205             


Leu Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly Ala 
    210                 215                 220                 


Gly Asn His Tyr Ala Glu Val Gln Val Val Asp Glu Ile Tyr Asp Lys 
225                 230                 235                 240 


His Ala Ala Ser Thr Met Gly Ile Asp Glu Glu Gly Gln Val Val Val 
                245                 250                 255     


Met Leu His Cys Gly Ser Arg Gly Leu Gly His Gln Val Ala Thr Asp 
            260                 265                 270         


Ser Leu Val Glu Met Glu Lys Ala Met Ala Arg Asp Gly Ile Val Val 
        275                 280                 285             


Asn Asp Lys Gln Leu Ala Cys Ala Arg Ile Asn Ser Val Glu Gly Lys 
    290                 295                 300                 


Asn Tyr Phe Ser Gly Met Ala Ala Ala Ala Asn Phe Ala Trp Val Asn 
305                 310                 315                 320 


Arg Ser Cys Ile Thr Phe Cys Val Arg Asn Ala Phe Gln Lys Thr Phe 
                325                 330                 335     


Gly Met Ser Ala Asp Asp Met Asp Met Gln Val Ile Tyr Asp Val Ser 
            340                 345                 350         


His Asn Val Ala Lys Met Glu Glu His Met Val Asp Gly Arg Pro Arg 
        355                 360                 365             


Gln Leu Cys Val His Arg Lys Gly Ala Thr Arg Ala Phe Pro Ala His 
    370                 375                 380                 


His Pro Leu Ile Pro Val Asp Tyr Gln Leu Ile Gly Gln Pro Val Leu 
385                 390                 395                 400 


Ile Gly Gly Ser Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr Glu 
                405                 410                 415     


Gln Gly Leu Val Glu Thr Phe Gly Thr Thr Cys His Gly Ala Gly Arg 
            420                 425                 430         


Ala Leu Ser Arg Ala Lys Ser Arg Arg Thr Ile Thr Trp Asp Ser Val 
        435                 440                 445             


Ile Asp Asp Leu Lys Lys Lys Glu Ile Ser Ile Arg Ile Ala Ser Pro 
    450                 455                 460                 


Lys Leu Ile Met Glu Glu Ala Pro Glu Ser Tyr Lys Asn Val Thr Asp 
465                 470                 475                 480 


Val Val Asp Thr Cys Asp Ala Ala Gly Ile Ser Lys Lys Ala Val Lys 
                485                 490                 495     


Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505 


<210>  7
<211>  476
<212>  PRT
<213>  C.reinhardtii

<400>  7

Met His Val Pro Gly Thr Phe Tyr Val Asn Asp Ala Leu Lys Gly Leu 
1               5                   10                  15      


Leu Phe Glu Glu Leu Gln Gln Ala Val Val Arg Gly Asp His Gly Gly 
            20                  25                  30          


Phe Leu Pro Ala Val Lys Gln Leu Ala Asn Val Ala Ala Leu Pro Gly 
        35                  40                  45              


Ile Val Lys Arg Ser Ile Ala Leu Pro Asp Val His Ser Gly Tyr Gly 
    50                  55                  60                  


Phe Ala Ile Gly Asn Val Ala Ala Phe Asp Met Asp Asn Pro Glu Ala 
65                  70                  75                  80  


Val Val Ser Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg 
                85                  90                  95      


Leu Leu Arg Thr Asn Leu Thr Glu Ala Glu Val Gly Pro Val Arg Glu 
            100                 105                 110         


Gln Leu Ala Gln Ala Leu Phe Asp His Ile Pro Val Gly Val Gly Ser 
        115                 120                 125             


Gln Gly Ile Ile Pro Thr Thr Ala Lys Asp Met Glu Ser Ala Leu Glu 
    130                 135                 140                 


Leu Gly Met Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp 
145                 150                 155                 160 


Lys Glu His Cys Glu Glu Tyr Gly Arg Met Leu Asn Ala Asp Pro Arg 
                165                 170                 175     


Tyr Val Ser Ser Arg Ala Lys Lys Arg Gly Leu Pro Gln Met Gly Thr 
            180                 185                 190         


Leu Gly Ala Gly Asn His Tyr Ala Glu Val Gln Val Val Asp Glu Val 
        195                 200                 205             


Tyr Asp Ala Val Ala Ala Arg Arg Met Gly Ile Asp Thr Pro Gly Gln 
    210                 215                 220                 


Val Val Val Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val 
225                 230                 235                 240 


Ala Thr Asp Ala Leu Val Ala Met Glu Arg Ala Met Ala Arg Asp Gly 
                245                 250                 255     


Ile Ile Thr Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Asn Ser Glu 
            260                 265                 270         


Glu Gly Gln Ala Tyr Leu Lys Ala Met Ser Cys Ala Ala Asn Tyr Ala 
        275                 280                 285             


Trp Val Asn Arg Ser Ser Met Thr Phe Leu Ala Arg Gln Ala Phe Ala 
    290                 295                 300                 


Lys Ile Phe Lys Ser Thr Pro Asp Asp Leu Asp Met His Val Val Tyr 
305                 310                 315                 320 


Asp Val Ser His Asn Ile Ala Lys Val Glu Gln His Cys Val Asp Gly 
                325                 330                 335     


Gln His Arg Arg Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe 
            340                 345                 350         


Pro Pro His His Pro Leu Ile Pro Ala Asp Tyr Gln Leu Ile Gly Gln 
        355                 360                 365             


Pro Val Leu Val Gly Gly Thr Met Gly Thr Ser Ser Tyr Val Leu Thr 
    370                 375                 380                 


Gly Thr Glu Gln Gly Phe Thr Glu Thr Phe Gly Ser Thr Cys His Gly 
385                 390                 395                 400 


Ala Gly Arg Ala Arg Ser Arg Asn Asn Ser Arg Asn Lys Leu Asp Tyr 
                405                 410                 415     


Gln Asp Val Leu Asp Asn Leu Lys Ala Lys Gly Ile Ala Ile Arg Val 
            420                 425                 430         


Ala Ser Pro Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asp 
        435                 440                 445             


Val Ser Glu Val Val Asp Thr Cys His Gln Ala Gly Ile Ser Lys Lys 
    450                 455                 460                 


Ala Val Lys Leu Arg Pro Ile Ala Val Ile Lys Gly 
465                 470                 475     


<210>  8
<211>  480
<212>  PRT
<213>  M.jannaschii

<400>  8

Met Lys Asp Val Leu Lys Arg Val Ser Asp Val Val Trp Glu Leu Pro 
1               5                   10                  15      


Lys Asp Tyr Lys Asp Cys Met Arg Val Pro Gly Arg Ile Tyr Leu Asn 
            20                  25                  30          


Glu Ile Leu Leu Asp Glu Leu Glu Pro Glu Val Leu Glu Gln Ile Ala 
        35                  40                  45              


Asn Val Ala Cys Leu Pro Gly Ile Tyr Lys Tyr Ser Ile Ala Met Pro 
    50                  55                  60                  


Asp Val His Tyr Gly Tyr Gly Phe Ala Ile Gly Gly Val Ala Ala Phe 
65                  70                  75                  80  


Asp Gln Arg Glu Gly Val Ile Ser Pro Gly Gly Val Gly Phe Asp Ile 
                85                  90                  95      


Asn Cys Gly Val Arg Leu Ile Arg Thr Asn Leu Thr Lys Glu Glu Val 
            100                 105                 110         


Gln Ser Lys Ile Lys Glu Leu Ile Lys Thr Leu Phe Lys Asn Val Pro 
        115                 120                 125             


Ser Gly Leu Gly Ser Lys Gly Ile Leu Lys Phe Ser Lys Ser Val Met 
    130                 135                 140                 


Asp Asp Val Leu Glu Glu Gly Val Arg Trp Ala Val Lys Glu Gly Tyr 
145                 150                 155                 160 


Gly Trp Lys Glu Asp Leu Glu Phe Ile Glu Glu His Gly Cys Leu Lys 
                165                 170                 175     


Asp Ala Asp Ala Ser Tyr Val Ser Asp Lys Ala Lys Glu Arg Gly Arg 
            180                 185                 190         


Val Gln Leu Gly Ser Leu Gly Ser Gly Asn His Phe Leu Glu Val Gln 
        195                 200                 205             


Tyr Val Glu Lys Val Phe Asp Glu Glu Ala Ala Glu Ile Tyr Gly Ile 
    210                 215                 220                 


Glu Glu Asn Gln Val Val Val Leu Val His Thr Gly Ser Arg Gly Leu 
225                 230                 235                 240 


Gly His Gln Ile Cys Thr Asp Tyr Leu Arg Ile Met Glu Lys Ala Ala 
                245                 250                 255     


Lys Asn Tyr Gly Ile Lys Leu Pro Asp Arg Gln Leu Ala Cys Ala Pro 
            260                 265                 270         


Phe Glu Ser Glu Glu Gly Gln Ser Tyr Phe Lys Ala Met Cys Cys Gly 
        275                 280                 285             


Ala Asn Tyr Ala Trp Ala Asn Arg Gln Met Ile Thr His Trp Val Arg 
    290                 295                 300                 


Glu Ser Phe Glu Glu Val Phe Lys Ile His Ala Glu Asp Leu Glu Met 
305                 310                 315                 320 


Asn Ile Val Tyr Asp Val Ala His Asn Ile Ala Lys Lys Glu Glu His 
                325                 330                 335     


Ile Ile Asp Gly Arg Lys Val Lys Val Ile Val His Arg Lys Gly Ala 
            340                 345                 350         


Thr Arg Ala Phe Pro Pro Lys His Glu Ala Ile Pro Lys Glu Tyr Trp 
        355                 360                 365             


Ser Val Gly Gln Pro Val Ile Ile Pro Gly Asp Met Gly Thr Ala Ser 
    370                 375                 380                 


Tyr Leu Met Arg Gly Thr Glu Ile Ala Met Lys Glu Thr Phe Gly Ser 
385                 390                 395                 400 


Thr Ala His Gly Ala Gly Arg Lys Leu Ser Arg Ala Lys Ala Leu Lys 
                405                 410                 415     


Leu Trp Lys Gly Lys Glu Ile Gln Arg Arg Leu Ala Glu Met Gly Ile 
            420                 425                 430         


Val Ala Met Ser Asp Ser Lys Ala Val Met Ala Glu Glu Ala Pro Glu 
        435                 440                 445             


Ala Tyr Lys Ser Val Asp Leu Val Ala Asp Thr Cys His Lys Ala Gly 
    450                 455                 460                 


Ile Ser Leu Lys Val Ala Arg Met Arg Pro Leu Gly Val Ile Lys Gly 
465                 470                 475                 480 


<210>  9
<211>  481
<212>  PRT
<213>  P.horikoshii

<400>  9

Met Val Val Pro Leu Lys Arg Ile Asp Lys Ile Arg Trp Glu Ile Pro 
1               5                   10                  15      


Lys Phe Asp Lys Arg Met Arg Val Pro Gly Arg Val Tyr Ala Asp Glu 
            20                  25                  30          


Val Leu Leu Glu Lys Met Lys Asn Asp Arg Thr Leu Glu Gln Ala Thr 
        35                  40                  45              


Asn Val Ala Met Leu Pro Gly Ile Tyr Lys Tyr Ser Ile Val Met Pro 
    50                  55                  60                  


Asp Gly His Gln Gly Tyr Gly Phe Pro Ile Gly Gly Val Ala Ala Phe 
65                  70                  75                  80  


Asp Val Lys Glu Gly Val Ile Ser Pro Gly Gly Ile Gly Tyr Asp Ile 
                85                  90                  95      


Asn Cys Gly Val Arg Leu Ile Arg Thr Asn Leu Thr Glu Lys Glu Val 
            100                 105                 110         


Arg Pro Arg Ile Lys Gln Leu Val Asp Thr Leu Phe Lys Asn Val Pro 
        115                 120                 125             


Ser Gly Val Gly Ser Gln Gly Arg Ile Lys Leu His Trp Thr Gln Ile 
    130                 135                 140                 


Asp Asp Val Leu Val Asp Gly Ala Lys Trp Ala Val Asp Asn Gly Tyr 
145                 150                 155                 160 


Gly Trp Glu Arg Asp Leu Glu Arg Leu Glu Glu Gly Gly Arg Met Glu 
                165                 170                 175     


Gly Ala Asp Pro Glu Ala Val Ser Gln Arg Ala Lys Gln Arg Gly Ala 
            180                 185                 190         


Pro Gln Leu Gly Ser Leu Gly Ser Gly Asn His Phe Leu Glu Val Gln 
        195                 200                 205             


Val Val Asp Lys Ile Phe Asp Pro Glu Val Ala Lys Ala Tyr Gly Leu 
    210                 215                 220                 


Phe Glu Gly Gln Val Val Val Met Val His Thr Gly Ser Arg Gly Leu 
225                 230                 235                 240 


Gly His Gln Val Ala Ser Asp Tyr Leu Arg Ile Met Glu Arg Ala Ile 
                245                 250                 255     


Arg Lys Tyr Arg Ile Pro Trp Pro Asp Arg Glu Leu Val Ser Val Pro 
            260                 265                 270         


Phe Gln Ser Glu Glu Gly Gln Arg Tyr Phe Ser Ala Met Lys Ala Ala 
        275                 280                 285             


Ala Asn Phe Ala Trp Ala Asn Arg Gln Met Ile Thr His Trp Val Arg 
    290                 295                 300                 


Glu Ser Phe Gln Glu Val Phe Lys Gln Asp Pro Glu Gly Asp Leu Gly 
305                 310                 315                 320 


Met Asp Ile Val Tyr Asp Val Ala His Asn Ile Gly Lys Val Glu Glu 
                325                 330                 335     


His Glu Val Asp Gly Lys Arg Val Lys Val Ile Val His Arg Lys Gly 
            340                 345                 350         


Ala Thr Arg Ala Phe Pro Pro Gly His Glu Ala Val Pro Arg Leu Tyr 
        355                 360                 365             


Arg Asp Val Gly Gln Pro Val Leu Ile Pro Gly Ser Met Gly Thr Ala 
    370                 375                 380                 


Ser Tyr Ile Leu Ala Gly Thr Glu Gly Ala Met Lys Glu Thr Phe Gly 
385                 390                 395                 400 


Ser Thr Cys His Gly Ala Gly Arg Val Leu Ser Arg Lys Ala Ala Thr 
                405                 410                 415     


Arg Gln Tyr Arg Gly Asp Arg Ile Arg Gln Glu Leu Leu Asn Arg Gly 
            420                 425                 430         


Ile Tyr Val Arg Ala Ala Ser Met Arg Val Val Ala Glu Glu Ala Pro 
        435                 440                 445             


Gly Ala Tyr Lys Asn Val Asp Asn Val Val Lys Val Val Ser Glu Ala 
    450                 455                 460                 


Gly Ile Ala Lys Leu Val Ala Arg Met Arg Pro Ile Gly Val Ala Lys 
465                 470                 475                 480 


Gly 
    


<210>  10
<211>  476
<212>  PRT
<213>  T.thermophilus

<400>  10

Met Phe Phe Glu Lys Ile Ala Pro Tyr Thr Tyr Arg Ile Pro Arg Gln 
1               5                   10                  15      


Gly Lys Met Arg Val Asp Ala Val Phe Phe Ala Ser Lys Glu Ile Leu 
            20                  25                  30          


Lys Asp Leu Glu Ala Glu Asn Tyr Ala Ser Leu Gln Gln Leu Met Asn 
        35                  40                  45              


Val Ala Thr Leu Pro Gly Ile Val Glu Pro Ala Leu Ala Met Pro Asp 
    50                  55                  60                  


Ile His Trp Gly Tyr Gly Phe Pro Ile Gly Gly Val Ala Ala Phe Asp 
65                  70                  75                  80  


Pro Glu Glu Gly Gly Val Val Ser Pro Gly Gly Val Gly Phe Asp Ile 
                85                  90                  95      


Asn Cys Gly Val Arg Leu Leu Ala Ser His Leu Thr Leu Glu Asp Leu 
            100                 105                 110         


Leu Pro Arg Gln Lys Glu Leu Ala Asp Ala Leu Tyr Arg Leu Val Pro 
        115                 120                 125             


Ser Gly Val Gly Ser Glu Arg Arg Asp Val Arg Phe Ser Lys Arg Glu 
    130                 135                 140                 


Leu Lys Glu Ile Leu Lys Glu Gly Ala Gly Trp Leu Val Lys Arg Gly 
145                 150                 155                 160 


Tyr Gly Tyr Pro Glu Asp Val Arg Phe Ile Glu Ser Gln Gly Arg Leu 
                165                 170                 175     


Pro Trp Ala Asn Pro Asp Lys Val Ser Glu Arg Ala Phe Glu Arg Gly 
            180                 185                 190         


Ala Pro Gln Ile Gly Thr Leu Gly Ser Gly Asn His Phe Leu Glu Val 
        195                 200                 205             


Gln Tyr Val Asp Glu Val Tyr Asp Glu Glu Ala Ala Leu Ala Phe Gly 
    210                 215                 220                 


Leu Phe Lys Gly Gln Val Thr Val Leu Ile His Thr Gly Ser Arg Gly 
225                 230                 235                 240 


Leu Gly His Gln Val Cys Gln Asp Tyr Val Glu Arg Phe Leu Lys Val 
                245                 250                 255     


Ala Pro Arg Tyr Gly Ile Glu Leu Val Asp Lys Gln Leu Ala Ala Ala 
            260                 265                 270         


Pro Ile Lys Ser Pro Glu Gly Gln Asp Tyr Leu Gln Ala Met Ala Ala 
        275                 280                 285             


Ala Ala Asn Phe Ala Phe Ala Asn Arg Gln Leu Ile Ala His Phe Val 
    290                 295                 300                 


Arg Glu Ala Phe Glu Lys Val Gly Phe Thr Pro Arg Asp His Gly Leu 
305                 310                 315                 320 


Arg Val Leu Tyr Asp Leu Ala His Asn Asn Ala Lys Phe Glu Glu His 
                325                 330                 335     


Arg Gly Arg Arg Val Leu Val His Arg Lys Gly Ala Thr Arg Ala Phe 
            340                 345                 350         


Gly Pro Gly His Pro Glu Val Pro Glu Glu Tyr Arg Arg Val Gly Gln 
        355                 360                 365             


Pro Val Leu Val Pro Gly Asp Met Gly Arg Tyr Ser Tyr Val Leu Ala 
    370                 375                 380                 


Gly Thr Glu Lys Ala Met Glu Val Ser Phe Gly Ser Ser Cys His Gly 
385                 390                 395                 400 


Ala Gly Arg Lys Met Ser Arg His Gln Ala Lys Lys Val Ala Arg Glu 
                405                 410                 415     


Arg Asn Leu Val Lys Glu Leu Ala Glu Arg Gly Ile Leu Val Arg Ala 
            420                 425                 430         


Ala Thr Arg Ala Thr Val Asp Glu Glu Met Pro Glu Ala Tyr Lys Asp 
        435                 440                 445             


Val Ser Leu Val Val Glu Ala Val Glu Gly Ala Gly Ile Gly Lys Lys 
    450                 455                 460                 


Val Ala Arg Leu Arg Pro Leu Ile Val Val Lys Gly 
465                 470                 475     


<210>  11
<211>  408
<212>  PRT
<213>  E.coli

<400>  11

Met Asn Tyr Glu Leu Leu Thr Thr Glu Asn Ala Pro Val Lys Met Trp 
1               5                   10                  15      


Thr Lys Gly Val Pro Val Glu Ala Asp Ala Arg Gln Gln Leu Ile Asn 
            20                  25                  30          


Thr Ala Lys Met Pro Phe Ile Phe Lys His Ile Ala Val Met Pro Asp 
        35                  40                  45              


Val His Leu Gly Lys Gly Ser Thr Ile Gly Ser Val Ile Pro Thr Lys 
    50                  55                  60                  


Gly Ala Ile Ile Pro Ala Ala Val Gly Val Asp Ile Gly Cys Gly Met 
65                  70                  75                  80  


Asn Ala Leu Arg Thr Ala Leu Thr Ala Glu Asp Leu Pro Glu Asn Leu 
                85                  90                  95      


Ala Glu Leu Arg Gln Ala Ile Glu Thr Ala Val Pro His Gly Arg Thr 
            100                 105                 110         


Thr Gly Arg Cys Lys Arg Asp Lys Gly Ala Trp Glu Asn Pro Pro Val 
        115                 120                 125             


Asn Val Asp Ala Lys Trp Ala Glu Leu Glu Ala Gly Tyr Gln Trp Leu 
    130                 135                 140                 


Thr Gln Lys Tyr Pro Arg Phe Leu Asn Thr Asn Asn Tyr Lys His Leu 
145                 150                 155                 160 


Gly Thr Leu Gly Thr Gly Asn His Phe Ile Glu Ile Cys Leu Asp Glu 
                165                 170                 175     


Ser Asp Gln Val Trp Ile Met Leu His Ser Gly Ser Arg Gly Ile Gly 
            180                 185                 190         


Asn Ala Ile Gly Thr Tyr Phe Ile Asp Leu Ala Gln Lys Glu Met Gln 
        195                 200                 205             


Glu Thr Leu Glu Thr Leu Pro Ser Arg Asp Leu Ala Tyr Phe Met Glu 
    210                 215                 220                 


Gly Thr Glu Tyr Phe Asp Asp Tyr Leu Lys Ala Val Ala Trp Ala Gln 
225                 230                 235                 240 


Leu Phe Ala Ser Leu Asn Arg Asp Ala Met Met Glu Asn Val Val Thr 
                245                 250                 255     


Ala Leu Gln Ser Ile Thr Gln Lys Thr Val Arg Gln Pro Gln Thr Leu 
            260                 265                 270         


Ala Met Glu Glu Ile Asn Cys His His Asn Tyr Val Gln Lys Glu Gln 
        275                 280                 285             


His Phe Gly Glu Glu Ile Tyr Val Thr Arg Lys Gly Ala Val Ser Ala 
    290                 295                 300                 


Arg Ala Gly Gln Tyr Gly Ile Ile Pro Gly Ser Met Gly Ala Lys Ser 
305                 310                 315                 320 


Phe Ile Val Arg Gly Leu Gly Asn Glu Glu Ser Phe Cys Ser Cys Ser 
                325                 330                 335     


His Gly Ala Gly Arg Val Met Ser Arg Thr Lys Ala Lys Lys Leu Phe 
            340                 345                 350         


Ser Val Glu Asp Gln Ile Arg Ala Thr Ala His Val Glu Cys Arg Lys 
        355                 360                 365             


Asp Ala Glu Val Ile Asp Glu Ile Pro Met Ala Tyr Lys Asp Ile Asp 
    370                 375                 380                 


Ala Val Met Ala Ala Gln Ser Asp Leu Val Glu Val Ile Tyr Thr Leu 
385                 390                 395                 400 


Arg Gln Val Val Cys Val Lys Gly 
                405             


<210>  12
<211>  1518
<212>  DNA
<213>  homo sapiens

<400>  12
atgagtcgca gctataatga tgagctgcag ttcttggaga agatcaataa aaactgctgg     60

aggatcaaga agggcttcgt gcccaacatg caggttgaag gtgttttcta tgtgaatgat    120

gctctggaga aattgatgtt tgaggaatta aggaatgcct gtcgaggtgg tggtgttggt    180

ggcttcctgc cagccatgaa acagattggc aatgtggcag ccctgcctgg aattgttcat    240

cgatctattg ggcttcctga tgtccattca ggatatgggt ttgctattgg gaacatggca    300

gcctttgata tgaatgaccc tgaagcagta gtatccccag gtggtgtcgg gtttgacatc    360

aactgtggtg tccgcttgct aagaaccaat ttagatgaaa gtgatgtcca gcctgtgaag    420

gagcaacttg cccaagctat gtttgaccac attcctgttg gggtggggtc aaaaggtgtc    480

atcccaatga atgccaaaga cttggaggag gccttggaga tgggggtgga ctggtcctta    540

agagaagggt atgcctgggc tgaagacaag gagcactgcg aggagtacgg aaggatgctg    600

caggctgacc ccaataaagt ttctgcaagg gcgaagaaaa gaggccttcc tcagttgggg    660

accctgggag caggcaacca ttatgcagaa atccaggttg tggatgagat tttcaatgag    720

tatgctgcta aaaaaatggg catcgaccat aagggacagg tgtgtgtgat gatccacagt    780

ggaagcagag gcttgggcca ccaagtagcc acagatgcgc tggtagctat ggagaaggcc    840

atgaagagag acaagattat agtcaatgat cggcagttgg cttgtgctcg aatcgcttcc    900

ccagagggtc aagactatct gaagggaatg gcagctgctg ggaactatgc ctgggtcaac    960

cgctcttcca tgaccttctt aacccgtcag gctttcgcca aggtcttcaa cacaacccct   1020

gatgacttgg acctacatgt gatttatgat gtttctcaca acattgccaa agtggagcag   1080

catgtggtgg acggaaagga acggacactg ttagtacaca ggaagggatc cacccgcgct   1140

ttccctcctc accatcccct cattgctgtt gattaccaac tcactggaca gccagtgctc   1200

attggtggca ccatgggaac ctgtagttat gttcttactg gcactgaaca gggcatgact   1260

gagacctttg gaacaacctg tcatggagcg ggccgtgcat tgtcccgagc aaaatctcga   1320

cgtaatttag atttccagga tgtcttagac aaattggcag atatgggaat tgcgatccgt   1380

gttgcctcac ccaaactggt tatggaagag gctcctgagt cctataagaa tgtgacagat   1440

gtggtaaata cctgccatga tgctggaatc agcaagaaag ccattaaact gagaccaatt   1500

gctgtgatca aaggatag                                                 1518


<210>  13
<211>  505
<212>  PRT
<213>  homo sapiens

<400>  13

Met Ser Arg Ser Tyr Asn Asp Glu Leu Gln Phe Leu Glu Lys Ile Asn 
1               5                   10                  15      


Lys Asn Cys Trp Arg Ile Lys Lys Gly Phe Val Pro Asn Met Gln Val 
            20                  25                  30          


Glu Gly Val Phe Tyr Val Asn Asp Ala Leu Glu Lys Leu Met Phe Glu 
        35                  40                  45              


Glu Leu Arg Asn Ala Cys Arg Gly Gly Gly Val Gly Gly Phe Leu Pro 
    50                  55                  60                  


Ala Met Lys Gln Ile Gly Asn Val Ala Ala Leu Pro Gly Ile Val His 
65                  70                  75                  80  


Arg Ser Ile Gly Leu Pro Asp Val His Ser Gly Tyr Gly Phe Ala Ile 
                85                  90                  95      


Gly Asn Met Ala Ala Phe Asp Met Asn Asp Pro Glu Ala Val Val Ser 
            100                 105                 110         


Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu Arg 
        115                 120                 125             


Thr Asn Leu Asp Glu Ser Asp Val Gln Pro Val Lys Glu Gln Leu Ala 
    130                 135                 140                 


Gln Ala Met Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly Val 
145                 150                 155                 160 


Ile Pro Met Asn Ala Lys Asp Leu Glu Glu Ala Leu Glu Met Gly Val 
                165                 170                 175     


Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp Lys Glu His 
            180                 185                 190         


Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Pro Asn Lys Val Ser 
        195                 200                 205             


Ala Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly Ala 
    210                 215                 220                 


Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile Phe Asn Glu 
225                 230                 235                 240 


Tyr Ala Ala Lys Lys Met Gly Ile Asp His Lys Gly Gln Val Cys Val 
                245                 250                 255     


Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val Ala Thr Asp 
            260                 265                 270         


Ala Leu Val Ala Met Glu Lys Ala Met Lys Arg Asp Lys Ile Ile Val 
        275                 280                 285             


Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Ala Ser Pro Glu Gly Gln 
    290                 295                 300                 


Asp Tyr Leu Lys Gly Met Ala Ala Ala Gly Asn Tyr Ala Trp Val Asn 
305                 310                 315                 320 


Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ala Lys Val Phe 
                325                 330                 335     


Asn Thr Thr Pro Asp Asp Leu Asp Leu His Val Ile Tyr Asp Val Ser 
            340                 345                 350         


His Asn Ile Ala Lys Val Glu Gln His Val Val Asp Gly Lys Glu Arg 
        355                 360                 365             


Thr Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe Pro Pro His 
    370                 375                 380                 


His Pro Leu Ile Ala Val Asp Tyr Gln Leu Thr Gly Gln Pro Val Leu 
385                 390                 395                 400 


Ile Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr Glu 
                405                 410                 415     


Gln Gly Met Thr Glu Thr Phe Gly Thr Thr Cys His Gly Ala Gly Arg 
            420                 425                 430         


Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Phe Gln Asp Val 
        435                 440                 445             


Leu Asp Lys Leu Ala Asp Met Gly Ile Ala Ile Arg Val Ala Ser Pro 
    450                 455                 460                 


Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asn Val Thr Asp 
465                 470                 475                 480 


Val Val Asn Thr Cys His Asp Ala Gly Ile Ser Lys Lys Ala Ile Lys 
                485                 490                 495     


Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505 


<210>  14
<211>  1521
<212>  DNA
<213>  Drosophila melanogaster

<400>  14
atggtggtgc gtccgtacaa cgatgagctc cggtacctgg agaaagtgag cgaccactgc     60

tggcgcatca agaagggctt ccagccaaat atgaatgtgg aggggtgttt ctatgtgaac    120

agccggctgg agcgcctgat gctggaggag ctgaagaact cctgtcgccc gggcgcagtg    180

ggtggcttcc tgcctggcgt caagcagata gccaatgtgg ccgcgttgcc gggcatcgtg    240

ggcaggtcca ttggactgcc cgacattcat tccggctacg gatttgccat cgggaacatg    300

gctgctttcg acatgaacga tccgctgtcc gttgtaagtc ccggcggcgt gggtttcgac    360

atcaactgtg gcgtgcgtct gctgcgcacg aatctgtacg agaaggatgt gcagccggtg    420

aaggagcaac tggcgcagtc cctgttcgat cacatacccg tgggtgtggg ctccaagggc    480

atcataccca tgaatgcccg cgatctggag gaggccctcg aaatgggcat ggactggtcg    540

ctgcgcgagg gatacgtgtg ggcggaggac aaggagcatt gcgaggagta cggccgcatg    600

ctgaacgccg atcccgccaa ggtgagcatg cgggccaaga agcgagggct gccccagctg    660

ggcactctgg gtgcgggcaa tcactacgcc gagatccagg tggtggacga aatctacgac    720

aagtggagcg cctccaagat gggcatcgag gagaagggcc aggtggtggt gatgattcac    780

tcgggcagtc gtggcttcgg ccaccaggtc gctaccgacg ccctggtcca gatggagaag    840

gccatgaagc gggacaagat cgagaccaat gaccggcagc tggcctgcgc caggatcaat    900

tcggtggagg gacaggacta cttgaaggcc atggcggcgg ctgcgaactt tgcctgggtg    960

aatcgcagct ccatgacatt cctcacccgt caagcgtttg ccaagatgtt taacaccaca   1020

cccgatgatc tcgacatgca cgttatctat gacgtttcgc acaatattgc caaggtggag   1080

aaccacatgg tggacggcaa ggagcggaag ctgttggttc accggaaggg ctccacgcgc   1140

gccttcccgc cacaccatcc cctgatccca gtggactatc agcttaccgg gcagccagtc   1200

ctcgtcggtg gaaccatggg cacttgcagt tacgtgctaa ctggaacgga gcagggcatg   1260

caggagacgt tcggtagcac ttgccacgga gcgggtcgtg cactatctcg agccaaatcc   1320

cggcgcaatc tggactacaa ggatgtgctg gacaagctgg accagttggg catcgccata   1380

cgcgtggcct cgcccaaact ggtcatggag gaggcacccg aatcttacaa ggacgtgacc   1440

gatgtggtcg acacctgtca cgcagctggc atcagcaaaa agtgcatcaa gatgcgccca   1500

attgcagtta tcaagggcta a                                             1521


<210>  15
<211>  506
<212>  PRT
<213>  Drosophila melanogaster

<400>  15

Met Val Val Arg Pro Tyr Asn Asp Glu Leu Arg Tyr Leu Glu Lys Val 
1               5                   10                  15      


Ser Asp His Cys Trp Arg Ile Lys Lys Gly Phe Gln Pro Asn Met Asn 
            20                  25                  30          


Val Glu Gly Cys Phe Tyr Val Asn Ser Arg Leu Glu Arg Leu Met Leu 
        35                  40                  45              


Glu Glu Leu Lys Asn Ser Cys Arg Pro Gly Ala Val Gly Gly Phe Leu 
    50                  55                  60                  


Pro Gly Val Lys Gln Ile Ala Asn Val Ala Ala Leu Pro Gly Ile Val 
65                  70                  75                  80  


Gly Arg Ser Ile Gly Leu Pro Asp Ile His Ser Gly Tyr Gly Phe Ala 
                85                  90                  95      


Ile Gly Asn Met Ala Ala Phe Asp Met Asn Asp Pro Leu Ser Val Val 
            100                 105                 110         


Ser Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu 
        115                 120                 125             


Arg Thr Asn Leu Tyr Glu Lys Asp Val Gln Pro Val Lys Glu Gln Leu 
    130                 135                 140                 


Ala Gln Ser Leu Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly 
145                 150                 155                 160 


Ile Ile Pro Met Asn Ala Arg Asp Leu Glu Glu Ala Leu Glu Met Gly 
                165                 170                 175     


Met Asp Trp Ser Leu Arg Glu Gly Tyr Val Trp Ala Glu Asp Lys Glu 
            180                 185                 190         


His Cys Glu Glu Tyr Gly Arg Met Leu Asn Ala Asp Pro Ala Lys Val 
        195                 200                 205             


Ser Met Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly 
    210                 215                 220                 


Ala Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile Tyr Asp 
225                 230                 235                 240 


Lys Trp Ser Ala Ser Lys Met Gly Ile Glu Glu Lys Gly Gln Val Val 
                245                 250                 255     


Val Met Ile His Ser Gly Ser Arg Gly Phe Gly His Gln Val Ala Thr 
            260                 265                 270         


Asp Ala Leu Val Gln Met Glu Lys Ala Met Lys Arg Asp Lys Ile Glu 
        275                 280                 285             


Thr Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Asn Ser Val Glu Gly 
    290                 295                 300                 


Gln Asp Tyr Leu Lys Ala Met Ala Ala Ala Ala Asn Phe Ala Trp Val 
305                 310                 315                 320 


Asn Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ala Lys Met 
                325                 330                 335     


Phe Asn Thr Thr Pro Asp Asp Leu Asp Met His Val Ile Tyr Asp Val 
            340                 345                 350         


Ser His Asn Ile Ala Lys Val Glu Asn His Met Val Asp Gly Lys Glu 
        355                 360                 365             


Arg Lys Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe Pro Pro 
    370                 375                 380                 


His His Pro Leu Ile Pro Val Asp Tyr Gln Leu Thr Gly Gln Pro Val 
385                 390                 395                 400 


Leu Val Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr 
                405                 410                 415     


Glu Gln Gly Met Gln Glu Thr Phe Gly Ser Thr Cys His Gly Ala Gly 
            420                 425                 430         


Arg Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Tyr Lys Asp 
        435                 440                 445             


Val Leu Asp Lys Leu Asp Gln Leu Gly Ile Ala Ile Arg Val Ala Ser 
    450                 455                 460                 


Pro Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asp Val Thr 
465                 470                 475                 480 


Asp Val Val Asp Thr Cys His Ala Ala Gly Ile Ser Lys Lys Cys Ile 
                485                 490                 495     


Lys Met Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505     


<210>  16
<211>  1518
<212>  DNA
<213>  Danio rerio

<400>  16
atgagtcgct cttacaacga tgagctccag tatctggata aaatacacaa aaactgctgg     60

cggatcaaga agggtttcgt gccgaatatg ctggtggaag gagtgtttta tgtcaatgac    120

ccgctggaaa agctgatgtt cgaggagctg agaaacgcct gtcgcggagg agggtttgga    180

ggtttcttac ctgcgatgaa gcagattggg aatgtggccg ctctgccagg aatcgtgcac    240

cggtcgatcg gtttaccgga cgttcactca ggatacggat tcgctatcgg gaacatggca    300

gcgttcgaca tggagaatcc ggacgcagtc gtctctccag gcggtgtggg tttcgatatt    360

aactgtggtg ttcgtctgct gcgcacaaac ctggatgagg gcgacgttca gccggtgaag    420

gagcagctgg cacagtctct cttcgaccac atccctgtcg gagtcggctc caagggcgtc    480

attcctatgg gtgcaaagga cctggaggag gcgttggaga tgggtgtgga ctggtctctg    540

agggagggat atgcctgggc ggaggataaa gagcactgtg aggagtacgg acgcatgctg    600

caggccgacc caaacaaagt ctcctccaaa gccaagaaga gaggactgcc acagttggga    660

actctgggtg caggaaacca ctacgcagag attcaggtgg tggacgagat ctacaatgat    720

tacgccgcca agaagatggg catcgatcat aaagggcagg tgtgtgtgat gatccacagc    780

ggcagccgag gactcggaca tcaggtggcc accgacgctc tggtggcgat ggagaaggcc    840

atgaagcgcg accgcatcac agtaaacgac cggcagctag cgtgcgcgcg catcacgtca    900

gaagagggac aggattatct gaagggaatg gcggcagcag gaaactacgc ctgggtcaac    960

cgatcctcca tgaccttcct cacacgacag gcgttctcca aagtgttcag caccacacca   1020

gatgatctgg acatgcacgt gatctacgac gtctcgcaca acatcgccaa agtggaggag   1080

cacatggtgg acggccggca gaaaacactg ctggtgcata ggaagggctc caccagagcg   1140

tttcctccac accatccact catacctgta gactatcagc tgaccggtca gccagtcctg   1200

attggaggaa ccatgggcac ctgcagttac gtgctcacag gcacagagca gggcatgaca   1260

gagacgttcg gcaccacatg tcacggcgct ggccgagctt tatccagagc caaatccaga   1320

cgcaacctgg acttccagga tgttctggat aaactggcag acatgggcat cgctattaga   1380

gtggcgtcac cgaagctggt gatggaggag gctcccgagt cctacaagaa cgtgacagac   1440

gtggtgaaca catgccatga tgccggcatc agcaaaaaag ccatcaaact cagacccatc   1500

gctgtgatta aaggttaa                                                 1518


<210>  17
<211>  505
<212>  PRT
<213>  Danio rerio

<400>  17

Met Ser Arg Ser Tyr Asn Asp Glu Leu Gln Tyr Leu Asp Lys Ile His 
1               5                   10                  15      


Lys Asn Cys Trp Arg Ile Lys Lys Gly Phe Val Pro Asn Met Leu Val 
            20                  25                  30          


Glu Gly Val Phe Tyr Val Asn Asp Pro Leu Glu Lys Leu Met Phe Glu 
        35                  40                  45              


Glu Leu Arg Asn Ala Cys Arg Gly Gly Gly Phe Gly Gly Phe Leu Pro 
    50                  55                  60                  


Ala Met Lys Gln Ile Gly Asn Val Ala Ala Leu Pro Gly Ile Val His 
65                  70                  75                  80  


Arg Ser Ile Gly Leu Pro Asp Val His Ser Gly Tyr Gly Phe Ala Ile 
                85                  90                  95      


Gly Asn Met Ala Ala Phe Asp Met Glu Asn Pro Asp Ala Val Val Ser 
            100                 105                 110         


Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu Arg 
        115                 120                 125             


Thr Asn Leu Asp Glu Gly Asp Val Gln Pro Val Lys Glu Gln Leu Ala 
    130                 135                 140                 


Gln Ser Leu Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly Val 
145                 150                 155                 160 


Ile Pro Met Gly Ala Lys Asp Leu Glu Glu Ala Leu Glu Met Gly Val 
                165                 170                 175     


Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp Lys Glu His 
            180                 185                 190         


Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Pro Asn Lys Val Ser 
        195                 200                 205             


Ser Lys Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly Ala 
    210                 215                 220                 


Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile Tyr Asn Asp 
225                 230                 235                 240 


Tyr Ala Ala Lys Lys Met Gly Ile Asp His Lys Gly Gln Val Cys Val 
                245                 250                 255     


Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val Ala Thr Asp 
            260                 265                 270         


Ala Leu Val Ala Met Glu Lys Ala Met Lys Arg Asp Arg Ile Thr Val 
        275                 280                 285             


Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Thr Ser Glu Glu Gly Gln 
    290                 295                 300                 


Asp Tyr Leu Lys Gly Met Ala Ala Ala Gly Asn Tyr Ala Trp Val Asn 
305                 310                 315                 320 


Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ser Lys Val Phe 
                325                 330                 335     


Ser Thr Thr Pro Asp Asp Leu Asp Met His Val Ile Tyr Asp Val Ser 
            340                 345                 350         


His Asn Ile Ala Lys Val Glu Glu His Met Val Asp Gly Arg Gln Lys 
        355                 360                 365             


Thr Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe Pro Pro His 
    370                 375                 380                 


His Pro Leu Ile Pro Val Asp Tyr Gln Leu Thr Gly Gln Pro Val Leu 
385                 390                 395                 400 


Ile Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr Glu 
                405                 410                 415     


Gln Gly Met Thr Glu Thr Phe Gly Thr Thr Cys His Gly Ala Gly Arg 
            420                 425                 430         


Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Phe Gln Asp Val 
        435                 440                 445             


Leu Asp Lys Leu Ala Asp Met Gly Ile Ala Ile Arg Val Ala Ser Pro 
    450                 455                 460                 


Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asn Val Thr Asp 
465                 470                 475                 480 


Val Val Asn Thr Cys His Asp Ala Gly Ile Ser Lys Lys Ala Ile Lys 
                485                 490                 495     


Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505 


<210>  18
<211>  1518
<212>  DNA
<213>  Bos sp.

<400>  18
atgagtcgca gttataatga tgagctgcag ttcttggaaa agatcagtaa gaactgctgg     60

agaatcaaga agggcttcgt gcccaacatg caggttgaag gagttttcta tgtgaatgat    120

tctctggaaa aattaatgtt tgaagaatta aggaatgcct gtcgaggtgg tggtgttggt    180

ggcttcctgc cagccatgaa acaaattggc aatgtggccg ccctgcctgg gattgttcat    240

cgatccatcg gtcttcctga tgtccattca ggttatgggt ttgctattgg aaatatggca    300

gcctttgata tgaacgaccc tgaagcagtg gtatccccag gtggtgttgg gtttgacatt    360

aactgtggtg tccgcttgct gagaaccaat ttagatgaaa gtgatgttca gcctgtgaaa    420

gagcaacttg cccaagctat gtttgaccac attcctgtgg gagtggggtc aaaaggtgtc    480

atcccaatga atgccaaaga cttggaggag gccttggaga tgggtgtgga ctggtccctg    540

agagaaggct atgcctgggc agaggacaag gagcactgtg aggagtatgg aaggatgctg    600

caagctgatc ccaataaagt ctcagccagg gctaaaaaaa gaggccttcc ccagttgggg    660

actctgggag caggcaacca ctatgcagaa atccaggttg tggatgagat tttcaacgag    720

tatgctgcta agaaaatggg cattgaccat aagggacagg tgtgtgtgat gatccacagt    780

ggaagcagag gcttgggcca ccaagttgcc acagatgcac ttgtagctat ggaaaaagcc    840

atgaagagag acaagattat agtcaatgac cgtcagttgg cttgtgctcg aattgcttcc    900

ccagagggtc aggactacct gaagggaatg gcagcggctg ggaactatgc ctgggtcaac    960

cgctcttcca tgaccttctt aacccgtcag gcttttgcca aggtcttcaa cacaacccct   1020

gatgacttgg acctgcatgt gatctatgat gtttctcaca atattgccaa agtagaacag   1080

catgtggtgg acgggaagga gcggactctg ttagtacaca ggaaggggtc cacccgagcc   1140

ttccctcctc accatcccct cattgcggtt gattaccaac ttaccggaca accagtgctc   1200

attggtggca ccatgggaac ctgtagctat gttcttactg gtactgagca gggcatgact   1260

gaaacctttg gaacaacttg tcatggagcg ggccgtgcac tgtcccgagc aaagtcaaga   1320

cgtaatttag atttccagga tgtcctcgac aaattggcag acatgggaat tgcaatccgt   1380

gtcgcctcac ccaagctggt aatggaagag gcccctgagt cctataagaa cgtgacggat   1440

gtggtgaaca cctgccatga tgccggaatc agcaagaagg ccattaaact gaggccaatt   1500

gctgttatca aaggatag                                                 1518


<210>  19
<211>  505
<212>  PRT
<213>  Bos sp.

<400>  19

Met Ser Arg Ser Tyr Asn Asp Glu Leu Gln Phe Leu Glu Lys Ile Ser 
1               5                   10                  15      


Lys Asn Cys Trp Arg Ile Lys Lys Gly Phe Val Pro Asn Met Gln Val 
            20                  25                  30          


Glu Gly Val Phe Tyr Val Asn Asp Ser Leu Glu Lys Leu Met Phe Glu 
        35                  40                  45              


Glu Leu Arg Asn Ala Cys Arg Gly Gly Gly Val Gly Gly Phe Leu Pro 
    50                  55                  60                  


Ala Met Lys Gln Ile Gly Asn Val Ala Ala Leu Pro Gly Ile Val His 
65                  70                  75                  80  


Arg Ser Ile Gly Leu Pro Asp Val His Ser Gly Tyr Gly Phe Ala Ile 
                85                  90                  95      


Gly Asn Met Ala Ala Phe Asp Met Asn Asp Pro Glu Ala Val Val Ser 
            100                 105                 110         


Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu Arg 
        115                 120                 125             


Thr Asn Leu Asp Glu Ser Asp Val Gln Pro Val Lys Glu Gln Leu Ala 
    130                 135                 140                 


Gln Ala Met Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly Val 
145                 150                 155                 160 


Ile Pro Met Asn Ala Lys Asp Leu Glu Glu Ala Leu Glu Met Gly Val 
                165                 170                 175     


Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp Lys Glu His 
            180                 185                 190         


Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Pro Asn Lys Val Ser 
        195                 200                 205             


Ala Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly Ala 
    210                 215                 220                 


Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile Phe Asn Glu 
225                 230                 235                 240 


Tyr Ala Ala Lys Lys Met Gly Ile Asp His Lys Gly Gln Val Cys Val 
                245                 250                 255     


Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val Ala Thr Asp 
            260                 265                 270         


Ala Leu Val Ala Met Glu Lys Ala Met Lys Arg Asp Lys Ile Ile Val 
        275                 280                 285             


Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Ala Ser Pro Glu Gly Gln 
    290                 295                 300                 


Asp Tyr Leu Lys Gly Met Ala Ala Ala Gly Asn Tyr Ala Trp Val Asn 
305                 310                 315                 320 


Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ala Lys Val Phe 
                325                 330                 335     


Asn Thr Thr Pro Asp Asp Leu Asp Leu His Val Ile Tyr Asp Val Ser 
            340                 345                 350         


His Asn Ile Ala Lys Val Glu Gln His Val Val Asp Gly Lys Glu Arg 
        355                 360                 365             


Thr Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe Pro Pro His 
    370                 375                 380                 


His Pro Leu Ile Ala Val Asp Tyr Gln Leu Thr Gly Gln Pro Val Leu 
385                 390                 395                 400 


Ile Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr Glu 
                405                 410                 415     


Gln Gly Met Thr Glu Thr Phe Gly Thr Thr Cys His Gly Ala Gly Arg 
            420                 425                 430         


Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Phe Gln Asp Val 
        435                 440                 445             


Leu Asp Lys Leu Ala Asp Met Gly Ile Ala Ile Arg Val Ala Ser Pro 
    450                 455                 460                 


Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asn Val Thr Asp 
465                 470                 475                 480 


Val Val Asn Thr Cys His Asp Ala Gly Ile Ser Lys Lys Ala Ile Lys 
                485                 490                 495     


Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505 


<210>  20
<211>  1518
<212>  DNA
<213>  Mus sp.

<400>  20
atgagtcgta actacaacga tgagctacag ttcttggaca agatcaataa aaactgctgg     60

aggatcaaga agggctttgt gcccaacatg caggttgaag gagtgtttta tgtgaatgat    120

gctctggaaa aactaatgtt tgaggaatta aggaacgcct gtcgaggtgg tggtgttggt    180

ggctttctgc cagccatgaa gcagattggc aatgtggcag ccctgcctgg aatagttcat    240

cggtctatcg ggcttcctga tgtccattca ggctatgggt ttgccatagg gaacatggct    300

gcctttgata tgaatgaccc tgaggccgtt gtatccccag gtggtgtcgg atttgatatt    360

aactgtggtg tccgcttgct aagaaccaat ttagatgaga gcgatgtaca gcctgtgaag    420

gaacaacttg cccaagctat gtttgaccac atccctgttg gggtgggatc aaaaggtgtc    480

attccaatga atgccaaaga cttggaggag gcattggaga tgggggtgga ctggtccctg    540

agggaaggct atgcctgggc tgaagacaag gagcactgtg aggagtatgg aaggatgctg    600

caagccgacc ccaataaggt ctcacccagg gcaaagaaaa ggggccttcc tcagttgggg    660

accctgggag caggcaacca ttatgcagaa atccaggttg tagatgagat tttcaatgag    720

tatgccgcca agaagatggg catcgaccat aagggacagg tgtgtgtgat gatccacagt    780

ggaagcagag gcttgggcca ccaagtagct acagatgcac tggtagctat ggaaaaggcc    840

atgaagagag acaagattat agtcaatgac cggcagttgg cttgtgctcg gattgcatcc    900

ccagagggac aagactatct aaagggaatg gctgcagctg gaaactacgc ctgggttaac    960

cgctcctcta tgaccttctt aacccgtcag gcttttgcca aagtcttcaa cacaacccct   1020

gatgacctgg acctgcatgt gatctatgat gtgtcgcaca atatcgccaa agtggagcag   1080

cacgtggtgg atgggaagga acggacgctg ctggtgcaca ggaagggatc cacccgtgct   1140

ttcccgcctc accaccccct cattgctgtg gattatcaac tcacaggaca accagtgctt   1200

attggtggca ccatggggac ctgtagttac gttctgactg gcactgaaca aggcatgact   1260

gagacctttg gaacaacctg tcatggagcg ggccgtgctt tgtccagagc aaaatcacgt   1320

cgtaacttag atttccaaga tgtcttagac aaactggcag acatgggaat tgcaatccgg   1380

gttgcttccc ccaagctggt tatggaagag gcaccagagt cctataagaa tgtgacagac   1440

gtcgtgaaca cctgccatga tgctgggatc agcaagaagg ccattaaact gagaccaatt   1500

gctgttatta aagggtag                                                 1518


<210>  21
<211>  505
<212>  PRT
<213>  Mus sp.

<400>  21

Met Ser Arg Asn Tyr Asn Asp Glu Leu Gln Phe Leu Asp Lys Ile Asn 
1               5                   10                  15      


Lys Asn Cys Trp Arg Ile Lys Lys Gly Phe Val Pro Asn Met Gln Val 
            20                  25                  30          


Glu Gly Val Phe Tyr Val Asn Asp Ala Leu Glu Lys Leu Met Phe Glu 
        35                  40                  45              


Glu Leu Arg Asn Ala Cys Arg Gly Gly Gly Val Gly Gly Phe Leu Pro 
    50                  55                  60                  


Ala Met Lys Gln Ile Gly Asn Val Ala Ala Leu Pro Gly Ile Val His 
65                  70                  75                  80  


Arg Ser Ile Gly Leu Pro Asp Val His Ser Gly Tyr Gly Phe Ala Ile 
                85                  90                  95      


Gly Asn Met Ala Ala Phe Asp Met Asn Asp Pro Glu Ala Val Val Ser 
            100                 105                 110         


Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu Arg 
        115                 120                 125             


Thr Asn Leu Asp Glu Ser Asp Val Gln Pro Val Lys Glu Gln Leu Ala 
    130                 135                 140                 


Gln Ala Met Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly Val 
145                 150                 155                 160 


Ile Pro Met Asn Ala Lys Asp Leu Glu Glu Ala Leu Glu Met Gly Val 
                165                 170                 175     


Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp Lys Glu His 
            180                 185                 190         


Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Pro Asn Lys Val Ser 
        195                 200                 205             


Pro Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly Ala 
    210                 215                 220                 


Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile Phe Asn Glu 
225                 230                 235                 240 


Tyr Ala Ala Lys Lys Met Gly Ile Asp His Lys Gly Gln Val Cys Val 
                245                 250                 255     


Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val Ala Thr Asp 
            260                 265                 270         


Ala Leu Val Ala Met Glu Lys Ala Met Lys Arg Asp Lys Ile Ile Val 
        275                 280                 285             


Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Ala Ser Pro Glu Gly Gln 
    290                 295                 300                 


Asp Tyr Leu Lys Gly Met Ala Ala Ala Gly Asn Tyr Ala Trp Val Asn 
305                 310                 315                 320 


Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ala Lys Val Phe 
                325                 330                 335     


Asn Thr Thr Pro Asp Asp Leu Asp Leu His Val Ile Tyr Asp Val Ser 
            340                 345                 350         


His Asn Ile Ala Lys Val Glu Gln His Val Val Asp Gly Lys Glu Arg 
        355                 360                 365             


Thr Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe Pro Pro His 
    370                 375                 380                 


His Pro Leu Ile Ala Val Asp Tyr Gln Leu Thr Gly Gln Pro Val Leu 
385                 390                 395                 400 


Ile Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr Glu 
                405                 410                 415     


Gln Gly Met Thr Glu Thr Phe Gly Thr Thr Cys His Gly Ala Gly Arg 
            420                 425                 430         


Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Phe Gln Asp Val 
        435                 440                 445             


Leu Asp Lys Leu Ala Asp Met Gly Ile Ala Ile Arg Val Ala Ser Pro 
    450                 455                 460                 


Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asn Val Thr Asp 
465                 470                 475                 480 


Val Val Asn Thr Cys His Asp Ala Gly Ile Ser Lys Lys Ala Ile Lys 
                485                 490                 495     


Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505 


<210>  22
<211>  1518
<212>  DNA
<213>  Rattus sp.

<400>  22
atgagtcgta actacaacga tgagctacag ttcttggaca agatcaataa gaactgctgg     60

aggatcaaga agggctttgt gcccaacatg caggttgaag gggtgtttta tgtgaatgac    120

gctctggaaa agctcatgtt tgaggagtta cggaatgcct gtcgaggtgg tggtgttggt    180

ggcttcctgc cagccatgaa gcagattggc aatgtggcag ccctgcctgg aatagttcat    240

cggtctattg ggcttcctga tgtccactca ggctacgggt ttgccatagg gaacatggct    300

gcctttgata tgaatgaccc tgaggcagtt gtatccccag gtggtgtcgg atttgatatt    360

aactgtggtg tccgcttgct aaggaccaat ttagatgaga gcgatgtaca gcctgtgaag    420

gaacaacttg cccaagctat gtttgaccac atccctgtcg gggtgggatc gaaaggtgtc    480

attccaatga atgccaaaga cttggaggag gcattggaga tgggtgtgga ctggtcccta    540

agagaaggct atgcctgggc tgaggacaag gagcactgtg aggagtatgg aaggatgctc    600

caagccgacc ccaataaggt ctcacccaga gcaaagaaaa ggggccttcc tcagttgggg    660

accctgggag caggcaacca ttatgcagag atccaggttg tagatgagat tttcaacgag    720

tatgctgcca agaagatggg catcgaccat aagggacagg tgtgcgtgat gatccacagc    780

gggagcagag gcttgggcca tcaagtagct acagacgcac tggtagctat ggagaaagcc    840

atgaagagag acaagattat agtcaatgac cggcagctgg cgtgtgctcg gattgcatcc    900

ccagagggac aagactatct aaagggaatg gctgccgctg gaaactgtgc ctgggttaac    960

cgctcgtcta tgaccttctt aacccgtcag gcttttgcca aagtcttcaa cacaacccct   1020

gacgacctgg acctgcatgt gatttatgat gtttctcaca acatcgccaa agtggagcag   1080

cacgtggtag acggaaagga gcggacgctg ttggtgcaca ggaaagggtc cacccgcgct   1140

ttccctcctc accatcccct cattgctgtt gattaccagc tcactggaca accagtgctt   1200

atcggtggca ccatggggac ctgtagttat gttctgactg gcactgaaca aggcatgact   1260

gagacctttg gaacaacctg tcatggagcg ggccgtgctt tgtccagagc aaaatcacgt   1320

cgtaatttag atttccaaga tgtcttagac aagctggcag acatgggaat cgccatccgg   1380

gttgcgtccc ccaagctggt tatggaagag gctccagaat catataagaa tgtgacagac   1440

gtcgtgaaca cttgccatga tgctgggatc agcaagaagg ccattaaact gagaccaatt   1500

gctgttatta aaggatag                                                 1518


<210>  23
<211>  505
<212>  PRT
<213>  Rattus sp.

<400>  23

Met Ser Arg Asn Tyr Asn Asp Glu Leu Gln Phe Leu Asp Lys Ile Asn 
1               5                   10                  15      


Lys Asn Cys Trp Arg Ile Lys Lys Gly Phe Val Pro Asn Met Gln Val 
            20                  25                  30          


Glu Gly Val Phe Tyr Val Asn Asp Ala Leu Glu Lys Leu Met Phe Glu 
        35                  40                  45              


Glu Leu Arg Asn Ala Cys Arg Gly Gly Gly Val Gly Gly Phe Leu Pro 
    50                  55                  60                  


Ala Met Lys Gln Ile Gly Asn Val Ala Ala Leu Pro Gly Ile Val His 
65                  70                  75                  80  


Arg Ser Ile Gly Leu Pro Asp Val His Ser Gly Tyr Gly Phe Ala Ile 
                85                  90                  95      


Gly Asn Met Ala Ala Phe Asp Met Asn Asp Pro Glu Ala Val Val Ser 
            100                 105                 110         


Pro Gly Gly Val Gly Phe Asp Ile Asn Cys Gly Val Arg Leu Leu Arg 
        115                 120                 125             


Thr Asn Leu Asp Glu Ser Asp Val Gln Pro Val Lys Glu Gln Leu Ala 
    130                 135                 140                 


Gln Ala Met Phe Asp His Ile Pro Val Gly Val Gly Ser Lys Gly Val 
145                 150                 155                 160 


Ile Pro Met Asn Ala Lys Asp Leu Glu Glu Ala Leu Glu Met Gly Val 
                165                 170                 175     


Asp Trp Ser Leu Arg Glu Gly Tyr Ala Trp Ala Glu Asp Lys Glu His 
            180                 185                 190         


Cys Glu Glu Tyr Gly Arg Met Leu Gln Ala Asp Pro Asn Lys Val Ser 
        195                 200                 205             


Pro Arg Ala Lys Lys Arg Gly Leu Pro Gln Leu Gly Thr Leu Gly Ala 
    210                 215                 220                 


Gly Asn His Tyr Ala Glu Ile Gln Val Val Asp Glu Ile Phe Asn Glu 
225                 230                 235                 240 


Tyr Ala Ala Lys Lys Met Gly Ile Asp His Lys Gly Gln Val Cys Val 
                245                 250                 255     


Met Ile His Ser Gly Ser Arg Gly Leu Gly His Gln Val Ala Thr Asp 
            260                 265                 270         


Ala Leu Val Ala Met Glu Lys Ala Met Lys Arg Asp Lys Ile Ile Val 
        275                 280                 285             


Asn Asp Arg Gln Leu Ala Cys Ala Arg Ile Ala Ser Pro Glu Gly Gln 
    290                 295                 300                 


Asp Tyr Leu Lys Gly Met Ala Ala Ala Gly Asn Cys Ala Trp Val Asn 
305                 310                 315                 320 


Arg Ser Ser Met Thr Phe Leu Thr Arg Gln Ala Phe Ala Lys Val Phe 
                325                 330                 335     


Asn Thr Thr Pro Asp Asp Leu Asp Leu His Val Ile Tyr Asp Val Ser 
            340                 345                 350         


His Asn Ile Ala Lys Val Glu Gln His Val Val Asp Gly Lys Glu Arg 
        355                 360                 365             


Thr Leu Leu Val His Arg Lys Gly Ser Thr Arg Ala Phe Pro Pro His 
    370                 375                 380                 


His Pro Leu Ile Ala Val Asp Tyr Gln Leu Thr Gly Gln Pro Val Leu 
385                 390                 395                 400 


Ile Gly Gly Thr Met Gly Thr Cys Ser Tyr Val Leu Thr Gly Thr Glu 
                405                 410                 415     


Gln Gly Met Thr Glu Thr Phe Gly Thr Thr Cys His Gly Ala Gly Arg 
            420                 425                 430         


Ala Leu Ser Arg Ala Lys Ser Arg Arg Asn Leu Asp Phe Gln Asp Val 
        435                 440                 445             


Leu Asp Lys Leu Ala Asp Met Gly Ile Ala Ile Arg Val Ala Ser Pro 
    450                 455                 460                 


Lys Leu Val Met Glu Glu Ala Pro Glu Ser Tyr Lys Asn Val Thr Asp 
465                 470                 475                 480 


Val Val Asn Thr Cys His Asp Ala Gly Ile Ser Lys Lys Ala Ile Lys 
                485                 490                 495     


Leu Arg Pro Ile Ala Val Ile Lys Gly 
            500                 505 


<210>  24
<211>  181
<212>  PRT
<213>  Encephalitozoon cuniculi

<400>  24

Met Met Tyr Ile Ser Val Gln Arg His Cys Ser Ser Leu Asp Pro His 
1               5                   10                  15      


Phe Phe Ser Thr Phe Arg Val Gly His Thr Asp Pro Gln Tyr Gln Met 
            20                  25                  30          


Gln Gly Thr Ser His Thr Ala Met Arg Ala Thr Ala Gly Lys Ser Leu 
        35                  40                  45              


Glu Ser Ile Glu Phe Leu Asp His Pro Ala Asp Ile Gln Met His Cys 
    50                  55                  60                  


Thr Ala Ser Ser Leu Pro Glu Leu Tyr Glu Val Ala Ile Lys Gly Met 
65                  70                  75                  80  


Met Ser Cys Ser Val Arg Ile Ser Ala Thr Asp Arg Arg Leu Gly Arg 
                85                  90                  95      


Val Glu Leu Ser Glu Thr Ser Asp Glu Met Asn Met Val Gly Leu Leu 
            100                 105                 110         


Thr His Phe Met Asp Leu Met Tyr Gly Glu Gly Leu Val Val Thr Glu 
        115                 120                 125             


Ala Ala Val Leu Leu Arg Asn Gly Leu Leu Val Cys Asp Tyr Ala Val 
    130                 135                 140                 


Thr Ser Gly Ser Arg Cys Gln Ser Leu Cys Glu Ile Lys Ala Val Thr 
145                 150                 155                 160 


Leu Cys Gly Leu Arg Val Phe Glu Glu Asp Gly Ile Phe His Leu Tyr 
                165                 170                 175     


Cys Ile Phe Asp Val 
            180     


<210>  25
<211>  205
<212>  PRT
<213>  Plasmodium berghei

<400>  25

Met Arg Asp Phe Pro Asn Ser Lys Ile Ile Ser Leu Pro Gln Arg Asn 
1               5                   10                  15      


Arg Arg Arg Ile Asn Arg Ser Tyr Val His Glu Glu Asn Glu Ser Glu 
            20                  25                  30          


Tyr Thr Asn Glu Ile Glu Glu Asn Glu Ala Thr Asn Asp Glu Ile Ile 
        35                  40                  45              


Asp Gln Asn Ile Met Asn Asp Ile Glu Ile Cys Asn Ile Asn Leu Asn 
    50                  55                  60                  


Lys Asn Tyr Lys Tyr Glu Tyr Leu Asp His Thr Ala Asp Ile Ile Leu 
65                  70                  75                  80  


His Ser Tyr Gly Asn Asn Leu Lys Glu Ala Phe Glu Ala Val Cys Ile 
                85                  90                  95      


Ser Leu Phe Asn Tyr Met Cys Asp Leu Lys Asn Val Glu Leu Lys Met 
            100                 105                 110         


Lys Arg Lys Val Ser Ile Lys Gly Asp Asp Leu Asp Asp Leu Leu Phe 
        115                 120                 125             


Lys Phe Leu Val Glu Phe His Phe Leu Tyr Gly Asn Glu Tyr Phe Ile 
    130                 135                 140                 


Cys Lys Thr Ile Asp Ile Ile Val Phe Asp Ile Glu Gln Phe Tyr Ile 
145                 150                 155                 160 


Glu Ala Tyr Gly Tyr Gly Glu Leu Phe Ser Thr Asp Lys His Glu Cys 
                165                 170                 175     


Gly Thr Glu Ile Lys Ala Ile Thr Lys His Glu Leu Lys Ile Val Ser 
            180                 185                 190         


Asn Asn Asp Ser Cys Asp Val Phe Val Leu Val Asp Ile 
        195                 200                 205 


<210>  26
<211>  112
<212>  PRT
<213>  Trichoplax adhaerens

<400>  26

Ala Leu Gly Met Leu Ala Tyr Ile Thr Asp Leu Arg Cys Val Glu Pro 
1               5                   10                  15      


Ile Lys Thr Gln Gln Ile Glu Ala Glu Gly His Asp Leu Glu Ser Leu 
            20                  25                  30          


Leu Tyr His Phe Leu Asp Glu Phe Leu Phe Leu Phe Ser Ala Glu Pro 
        35                  40                  45              


Phe Phe Ile Ala Lys Asn Val Lys Ile Leu Lys Phe Asp Lys Glu Asn 
    50                  55                  60                  


Phe Arg Ile Thr Ala Glu Gly Val Gly Glu Ile Phe Asp Leu Ser Arg 
65                  70                  75                  80  


His Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr Ser Asn Met Gln 
                85                  90                  95      


Ile Phe Asp Ser Ile Asn Lys His Glu Cys Tyr Val Ile Val Asp Ile 
            100                 105                 110         


<210>  27
<211>  148
<212>  PRT
<213>  Hydra magnipapillata

<400>  27

Met Glu Ser Asp Ser Ser Asp Asn Tyr Gly Tyr Glu Tyr Leu Asp His 
1               5                   10                  15      


Pro Ala Asp Ile Gln Ile His Ser Trp Gly Leu Thr Leu Lys Gln Ala 
            20                  25                  30          


Phe Glu Gln Gln Ala Ile Gly Met Phe Gly Ile Met Thr Asp Leu Asn 
        35                  40                  45              


Thr Ile Glu Asn Leu Gln Glu Glu Val Ile Glu Ala Glu Gly His Asp 
    50                  55                  60                  


Leu Val Ser Leu Leu Tyr Lys Phe Leu Asp Glu Cys Leu Phe Ala Phe 
65                  70                  75                  80  


Ser Val Glu Pro Phe Leu Cys Ala Phe Asp Val Asn Ile Thr Glu Phe 
                85                  90                  95      


Asp Glu Glu Asn Phe Val Ile Lys Ala Val Leu Lys Gly Glu Thr Phe 
            100                 105                 110         


Asp Leu Ser Lys His Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Phe 
        115                 120                 125             


Ser Asn Met Gln Ile Asn Lys Glu Ser Ala His Trp Glu Cys Tyr Val 
    130                 135                 140                 


Ile Phe Asp Ile 
145             


<210>  28
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Gln Glu Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu 
1               5                   10                  15      


Gln Lys Ala Ile Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu 
            20                  25                  30          


Tyr Leu Asp His Thr Ala Asp Val Gln Leu His Ala Trp Gly Asp Thr 
        35                  40                  45              


Leu Glu Glu Ala Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met 
    50                  55                  60                  


Thr Asp Thr Gly Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr 
65                  70                  75                  80  


Gln Gly Asp Asp Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp 
                85                  90                  95      


Leu Tyr Lys Phe Ser Ala Asp Glu Phe Phe Ile Pro Arg Glu Val Lys 
            100                 105                 110         


Val Leu Ser Ile Asp Gln Arg Asn Phe Lys Leu Arg Ser Ile Gly Trp 
        115                 120                 125             


Gly Glu Glu Phe Ser Leu Ser Lys His Pro Gln Gly Thr Glu Val Lys 
    130                 135                 140                 


Ala Ile Thr Tyr Ser Ala Met Gln Val Tyr Asn Glu Glu Asn Pro Glu 
145                 150                 155                 160 


Val Phe Val Ile Ile Asp Ile 
                165         


<210>  29
<211>  156
<212>  PRT
<213>  Drosophila melanogaster

<400>  29

Met Glu Val Glu Phe Ser Arg Glu Asn Phe Leu Leu Pro Glu Met Lys 
1               5                   10                  15      


Tyr Glu Tyr Leu Asp His Thr Ala Asp Val Gln Ile His Gly Trp Gly 
            20                  25                  30          


Ser Ser Leu Lys Glu Ala Phe Glu Gln Cys Gly Val Ala Met Phe Gly 
        35                  40                  45              


Tyr Met Thr Glu Leu Asp Tyr Val Ser Val Glu Gln Cys Phe Glu Ile 
    50                  55                  60                  


Glu Ala His Gly Asp Asp Leu Glu Ser Leu Leu Phe His Phe Leu Asp 
65                  70                  75                  80  


Glu Leu Leu Phe Leu Phe Ser Ala Glu Pro Tyr Leu Val Cys Lys Lys 
                85                  90                  95      


Leu Glu Ile Thr Lys Phe Asp Val Glu Asn Phe Glu Ile Ser Cys His 
            100                 105                 110         


Cys Tyr Gly Glu Pro Phe Glu Leu Gly Lys His Pro Gln Gly Thr Glu 
        115                 120                 125             


Val Lys Ala Ile Thr Tyr Ser Ala Met Gln Ile Ile Gln Asp Val Glu 
    130                 135                 140                 


Ala Ser Asn Tyr Glu Val Phe Val Ile Ile Asp Ile 
145                 150                 155     


<210>  30
<211>  151
<212>  PRT
<213>  Dictyostelium discoideum

<400>  30

Met Glu Ser Tyr Gly Leu Gly Gln Leu Lys Asn Phe Glu Tyr Leu Asp 
1               5                   10                  15      


His Thr Ala Asp Ile Met Phe His Thr Trp Gly Lys Asp Leu Lys Glu 
            20                  25                  30          


Ala Leu Glu Gln Met Val Leu Ile Met Asn Asn Tyr Met Val Glu Leu 
        35                  40                  45              


Asp Ser Val Glu Leu Asp Asp Ser Ala Thr Glu Gln Thr Ile Ser Val 
    50                  55                  60                  


Asn Gly His Asp Met Asp Ser Leu Leu Phe Ala Leu Leu Asp Glu Phe 
65                  70                  75                  80  


Leu Phe Val Phe Ser Thr Glu Phe Ile Ile Phe Lys Gln Val Gln Ile 
                85                  90                  95      


Ile Ser Phe Asp Arg Glu Asn Phe Ser Ile Lys Ala Ile Gly Lys Gly 
            100                 105                 110         


Val Glu Leu Asp Lys Ser Lys His Thr Thr Gly Thr Glu Ile Lys Ala 
        115                 120                 125             


Ile Thr Tyr Ser Cys Met Lys Ile Glu Glu Asn Pro Asp Lys Ser Asp 
    130                 135                 140                 


Ile His Val Ile Val Asp Ile 
145                 150     


<210>  31
<211>  260
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  31

Met Gly Gly Glu Glu Asp Ala Leu Pro Gln Arg Leu Asn Ser Arg Gln 
1               5                   10                  15      


Arg Arg Arg Glu Gln Gln His Gln Val Gln Gln Gly Thr Glu Ala Ala 
            20                  25                  30          


Ser Gly Ile Glu Asp Gly Ala Ala Gln Ala Pro Ser Ala Ser Gly Arg 
        35                  40                  45              


Gln Gly Arg Glu Glu His Gly Ala Gly Leu Gly Glu Gly Arg Ser Lys 
    50                  55                  60                  


Ala Ala Pro Ala Gly Thr Pro Arg Arg Pro Glu Ser Arg Ser Ala Ser 
65                  70                  75                  80  


Arg Asp Thr Lys Ser Asp Pro Gly Leu Gly Lys Asp Ser Gly Val Ser 
                85                  90                  95      


Gly Val Cys Val Glu Val Gly Ala Val Thr Thr Leu Glu Pro Leu Pro 
            100                 105                 110         


Glu Tyr Arg Ser Ala Ala Val Gly Asp Tyr Lys Phe Glu Tyr Leu Asp 
        115                 120                 125             


His Thr Ala Asp Val Gln Leu His Ala Trp Gly Ser Asp Leu Gly Glu 
    130                 135                 140                 


Ala Phe Glu Gln Cys Gly Leu Ala Met Phe Asn Tyr Met Ser Pro Leu 
145                 150                 155                 160 


Glu His Val Arg Leu Arg Glu Thr Arg Ala Tyr Arg Ala Glu Gly His 
                165                 170                 175     


Asp Leu Pro Ser Leu Leu Phe Ala Phe Leu Asp Glu Leu Leu Phe Glu 
            180                 185                 190         


Phe Asn Thr Glu Leu Phe Leu Ala Gly Arg Val Arg Ile Thr Lys Phe 
        195                 200                 205             


Asp Arg Glu Ala Phe Val Ile Glu Ala Glu Gly His Gly Glu Arg Phe 
    210                 215                 220                 


Asp Arg Ser Leu His Glu Val Gly Thr Glu Ile Lys Ala Ile Thr Tyr 
225                 230                 235                 240 


Ser Ala Met Ser Ile Ser Glu Gln Glu Gly Asp Ala Glu Val Phe Val 
                245                 250                 255     


Ile Val Asp Ile 
            260 


<210>  32
<211>  167
<212>  PRT
<213>  Caligus rogercresseyi

<400>  32

Met Glu Arg Glu Asp Pro Thr Gln Glu Ser Asp Gln Asp Arg Pro Thr 
1               5                   10                  15      


Ser Gly Tyr Glu Tyr Leu Asp His Thr Ala Asp Val Gln Ile His Ala 
            20                  25                  30          


Trp Ser Ser Thr Leu Arg Glu Ala Ile Cys Glu Ala Ala Leu Gly Val 
        35                  40                  45              


Tyr Asn Tyr Met Thr Asp Leu Ser Ala Val Thr Ala Ser Glu Asp Leu 
    50                  55                  60                  


Ile Leu Lys Ala Gln Gly His Asp Leu Glu Ser Leu Leu Tyr Asn Phe 
65                  70                  75                  80  


Leu Asp Glu Cys Leu Tyr His Phe His Ala Glu Glu Tyr Phe Val Ala 
                85                  90                  95      


Cys Glu Val Glu Leu Ile Asp Phe Asp Arg Val Arg Ser Gln Gly Glu 
            100                 105                 110         


Glu Gly Lys Glu Glu Lys Glu Leu Ser Ile Thr Ala Arg Leu Arg Gly 
        115                 120                 125             


Glu Lys Phe Asp Leu Asn Lys His Ser Pro Gly Thr Glu Ile Lys Ala 
    130                 135                 140                 


Ile Thr Tyr Ser Ala Met Gln Val Leu Glu Lys Asp Cys Phe Ala Gln 
145                 150                 155                 160 


Met Phe Val Ile Val Asp Ile 
                165         


<210>  33
<211>  155
<212>  PRT
<213>  Caenorhabditis elegans

<400>  33

Met Pro Ser Thr Ser Met Ile Glu Asp Arg Ser Glu Ile Glu Arg Arg 
1               5                   10                  15      


Arg Phe Glu Tyr Leu Asp His Pro Ala Asp Ile Gln Leu His Ser Trp 
            20                  25                  30          


Gly Ser Thr Met Glu Glu Ala Phe Glu Ala Cys Leu Val Ser Met Phe 
        35                  40                  45              


Gly Tyr Met Thr Asp Leu Ala Lys Val Asp Glu Met Tyr Glu Phe Tyr 
    50                  55                  60                  


Trp Lys Ala Ser Gly Asp Ser Leu Asp Gly Leu Leu Phe Gln Phe Leu 
65                  70                  75                  80  


Asp Glu Ala Leu Asn Ser Phe His Ala Glu Pro Cys Phe Val Ala Lys 
                85                  90                  95      


Arg Val Glu Ile Leu Arg Phe Asp Lys Lys Lys Phe Glu Ile Glu Phe 
            100                 105                 110         


Arg Gly Trp Gly Glu Ser Phe Asp Thr Ser Lys His Glu Thr Glu Ala 
        115                 120                 125             


Asp Ile Lys Ser Pro Thr Tyr Ser Asn Met Gln Ile Asn Glu Lys Pro 
    130                 135                 140                 


Glu Arg Cys Asp Ile Tyr Val Ile Val Asp Ile 
145                 150                 155 


<210>  34
<211>  143
<212>  PRT
<213>  Entamoeba histolytica

<400>  34

Met Ser Phe Glu Tyr Leu Asp His Pro Ala Asp Val Ile Leu His Ser 
1               5                   10                  15      


Trp Gly Gln Asn Ile Ile Glu Ala Phe Glu Asn Ala Ala Ala Gly Met 
            20                  25                  30          


Phe Asn Phe Met Ser Asp Leu Thr Lys Val Glu Glu Lys Glu Ile Lys 
        35                  40                  45              


Lys Ile Ser Ile Asp Ala Thr Ser Tyr Glu Glu Ala Leu Val Lys Phe 
    50                  55                  60                  


Leu Asp Ser Trp Leu Cys Ile Phe Ser Ser Glu Leu Phe Ile Gly Lys 
65                  70                  75                  80  


Ser Phe Lys Cys Glu Val Phe Asp Asp Asn Asp Glu Glu Asn Ile His 
                85                  90                  95      


Ile Glu Cys Lys Gly Ile Gly Glu Tyr Phe Val Ile Gly Lys His Gln 
            100                 105                 110         


Gln Gly Thr Glu Ile Lys Ala Ile Thr Trp His Asn Leu Glu Ile Tyr 
        115                 120                 125             


Asp Asp Glu Lys Asp Gln Thr His Ile His Ile Leu Leu Asp Ile 
    130                 135                 140             


<210>  35
<211>  139
<212>  PRT
<213>  Sulfolobus islandicus

<400>  35

Met Arg Ser Phe Glu Phe Phe Glu His Thr Ala Asp Val Gly Ile Arg 
1               5                   10                  15      


Ala Tyr Gly Lys Ser Leu Glu Glu Ala Phe Ser Asn Ala Ala Leu Gly 
            20                  25                  30          


Val Phe Glu Val Ile Thr Asp Thr Ser Lys Val Lys Pro Ile Glu Tyr 
        35                  40                  45              


Arg Glu Ile Tyr Leu Asn Gly Tyr Asp Leu Glu Asn Leu Leu Tyr Lys 
    50                  55                  60                  


Trp Ile Glu Glu Leu Leu Tyr Tyr Tyr Asp Ser Glu Leu Met Val Phe 
65                  70                  75                  80  


Ser Lys Phe Asp Leu Met Ile Asp Gln Asp Ser Met Thr Leu Glu Gly 
                85                  90                  95      


Lys Ala Trp Gly Glu Lys Phe Asn Gly Lys Ile His Glu Arg Arg Thr 
            100                 105                 110         


Val Val Lys Ala Met Thr Tyr His Gln Leu Ser Ile Glu Lys Thr Glu 
        115                 120                 125             


Asn Cys Tyr Val Ile Thr Phe Val Val Asp Ile 
    130                 135                 


<210>  36
<211>  138
<212>  PRT
<213>  Methanococcus maripaludis

<400>  36

Met Tyr Asn Tyr Phe Glu Thr Thr Ala Asp Ile Gly Ile Ile Ala Phe 
1               5                   10                  15      


Gly Lys Thr Leu Glu Glu Ser Phe Glu Asn Ser Ala Arg Gly Leu Ser 
            20                  25                  30          


Asn Ile Met Val Asp Ile Lys Ser Ile Glu Lys Ile Glu Lys His Ser 
        35                  40                  45              


Phe Lys Val Ile Ser Glu Asp Leu Phe Gly Leu Leu Tyr Asp Phe Leu 
    50                  55                  60                  


Thr Glu Leu Leu Ile Leu Gln Asp Ser Glu Leu Leu Ile Phe Ser Glu 
65                  70                  75                  80  


Phe Asn Val Lys Ile Glu Arg Asn Glu Cys Tyr Glu Leu Ser Cys Val 
                85                  90                  95      


Ala Phe Gly Asp Arg Tyr Ser Lys Asp Lys Tyr Glu Pro Lys Glu Glu 
            100                 105                 110         


Val Lys Ala Ile Thr Tyr His Arg Met Glu Ile Ser Lys Ser Glu Asn 
        115                 120                 125             


Cys Trp Lys Thr Gln Phe Ile Val Asp Leu 
    130                 135             


<210>  37
<211>  137
<212>  PRT
<213>  Archaeoglobus fulgidus

<400>  37

Met Lys Tyr Arg Phe Ile Asp His Thr Ala Asp Ile Ala Phe Glu Val 
1               5                   10                  15      


Tyr Gly Ser Asn Leu Arg Glu Leu Phe Glu Asn Ala Ala Leu Ala Phe 
            20                  25                  30          


Tyr Asp Ala Phe Val Asp Thr Ser Gly Ile Gly Ile Glu Arg Glu Val 
        35                  40                  45              


Gly Val Glu Cys Glu Gly Glu Asp Val Glu Ile Thr Leu Tyr Arg Trp 
    50                  55                  60                  


Leu Asn Glu Leu Leu Tyr Leu Phe Asp Thr Glu Phe Phe Ala Ala Lys 
65                  70                  75                  80  


Asp Val Glu Val Glu Val Glu Glu Gly Asp Gly Val Lys Ala Ser Gly 
                85                  90                  95      


Lys Leu Arg Gly Gly Arg Phe Ser Ala Glu Met Val Lys Val Glu Pro 
            100                 105                 110         


Lys Ala Ile Thr Leu His Lys Phe Arg Val Glu Lys Thr Asp Lys Gly 
        115                 120                 125             


Tyr Val Ala Phe Val Val Val Asp Ile 
    130                 135         


<210>  38
<211>  140
<212>  PRT
<213>  Synechococcus sp.

<400>  38

Met Ala Arg Ala Arg Trp Asp His Phe Glu His Met Ala Asp Val Gly 
1               5                   10                  15      


Val Arg Gly Tyr Gly Ala Thr Pro Glu Glu Ala Phe Ala Gln Ala Ala 
            20                  25                  30          


Leu Ala Leu Thr Ala Val Ile Thr Ser Val Asp Glu Val Ala Pro Arg 
        35                  40                  45              


Glu Arg Leu Glu Ile Glu Leu Glu Asn Ser Gly Asp Leu Glu Leu Leu 
    50                  55                  60                  


Leu Val Asp Phe Leu Asn Ala Val Ile Tyr Glu Met Ala Val Arg Gly 
65                  70                  75                  80  


Met Leu Phe Gly Lys Val Glu Val His Leu Ala Lys Asp His Leu Lys 
                85                  90                  95      


Ala Ser Leu Trp Gly Glu Arg Val Asp Arg Ala Lys His Arg Pro Ala 
            100                 105                 110         


Val Glu Val Lys Gly Ala Thr Tyr Thr Gln Leu Lys Val Ala Gln Glu 
        115                 120                 125             


Ser Glu Leu Trp Val Ala Gln Cys Val Val Asp Val 
    130                 135                 140 


<210>  39
<211>  140
<212>  PRT
<213>  Aquifex aeolicus

<400>  39

Met Val Lys Leu Asp Tyr Glu Pro Val Tyr Asp Ile Thr Ala Asp Ala 
1               5                   10                  15      


Gly Ile Arg Val Arg Ala Lys Thr Leu Glu Glu Leu Phe Cys His Ala 
            20                  25                  30          


Ile Leu Ala Thr Phe Asn Glu Ile Thr Asp Ile Asp Lys Val Glu Pro 
        35                  40                  45              


Lys Glu Glu Tyr Glu Ile Gln Ala Gln Asn Asp Met Pro Phe Leu Leu 
    50                  55                  60                  


Ala Asp Ile Ile Asn Glu Ala Leu Val Leu His Glu Ser Lys His Phe 
65                  70                  75                  80  


Val Ala Ser Glu Cys Glu Val Leu Glu Leu Lys Glu Asp Phe Val Lys 
                85                  90                  95      


Val Lys Leu Lys Gly Glu Lys Phe Asp Pro Lys Arg His Pro Ser Lys 
            100                 105                 110         


Leu Val Ile Lys Ala Ala Thr Tyr His Arg Leu Arg Val Glu Lys Lys 
        115                 120                 125             


Asn Glu His Trp Glu Ala Glu Val Ile Phe Asp Ile 
    130                 135                 140 


<210>  40
<211>  139
<212>  PRT
<213>  Thermus thermophilus

<400>  40

Met Val Val Arg Pro Leu Asp His Thr Ala Asp Val Gly Phe Ala Leu 
1               5                   10                  15      


Glu Ala Gln Asn Leu Glu Glu Leu Phe Gln Ala Ala Leu Lys Gly Leu 
            20                  25                  30          


Leu Asp Val Met Phe Thr Ala Pro Pro Gln Gly Gly Arg Lys Arg Arg 
        35                  40                  45              


Arg Leu Arg Leu Phe Ala Glu Asp Leu Glu Thr Leu Leu Val Arg Phe 
    50                  55                  60                  


Leu Asn Glu Leu Ile Tyr Leu Ile Gln Thr Lys Gly Phe Val Pro Gly 
65                  70                  75                  80  


Arg Ala Arg Ile Arg Val Glu Glu Glu Glu Gly Gly Tyr Arg Leu Ile 
                85                  90                  95      


Ala Thr Leu Phe Gly Glu Pro Phe Gln Glu Gly Leu Gly Phe Gln Gly 
            100                 105                 110         


Glu Val Lys Ser Ala Thr Phe His Gly Leu Ser Val Arg Lys Glu Asp 
        115                 120                 125             


Asp Arg Trp Lys Ala Gln Val Ile Leu Asp Val 
    130                 135                 


<210>  41
<211>  143
<212>  PRT
<213>  Archaeal BJ1

<400>  41

Met Ser Tyr Ala Leu Arg Asp His Thr Ala Asp Val Ala Val Glu Ala 
1               5                   10                  15      


Thr Ala Pro Thr Leu Ala Ala Leu Phe Glu Ala Val Ala Asp Gly Leu 
            20                  25                  30          


Thr Ala Ala Ser Cys Glu Ala Val Pro Glu Gly Gly Asp Arg Phe Glu 
        35                  40                  45              


Leu Ser Val Thr Ala Glu Ser Arg Glu Ala Leu Leu Phe Asp Tyr Leu 
    50                  55                  60                  


Asp Gln Leu Ile Tyr Glu Arg Asp Val Arg Leu Val Leu Pro Ala Asp 
65                  70                  75                  80  


His Arg Cys Thr Val Ser Gly Pro Asp Asp Thr Glu Ser Gly Asp Asp 
                85                  90                  95      


Ala Ala Trp Thr Val Glu Ala Thr Ala Arg Gly Val Pro Leu Gly Asp 
            100                 105                 110         


Val Ala Ala Arg Glu Ile Lys Ala Val Thr Tyr Ser Glu Met Thr Leu 
        115                 120                 125             


Asp Arg Arg Asp Asp Gly Trp Tyr Ala Tyr Val Val Phe Asp Val 
    130                 135                 140             


<210>  42
<211>  179
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  42

Met Leu His Arg Asp Asp His Ile Asn Pro Pro Arg Pro Arg Gly Leu 
1               5                   10                  15      


Asp Val Pro Cys Ala Arg Leu Arg Ala Thr Asn Pro Leu Arg Ala Leu 
            20                  25                  30          


Ala Arg Cys Val Gln Ala Gly Lys Pro Gly Thr Ser Ser Gly His Arg 
        35                  40                  45              


Ser Val Pro His Thr Ala Asp Leu Arg Ile Glu Ala Trp Ala Pro Thr 
    50                  55                  60                  


Arg Asp Gly Cys Ile Arg Gln Ala Val Leu Gly Thr Val Glu Ser Phe 
65                  70                  75                  80  


Leu Asp Leu Glu Ser Ala His Ala Val His Thr Arg Leu Arg Arg Leu 
                85                  90                  95      


Thr Ala Asp Arg Asp Asp Asp Leu Leu Val Ala Val Leu Glu Glu Val 
            100                 105                 110         


Ile Tyr Leu Leu Asp Thr Val Gly Glu Thr Pro Val Asp Leu Arg Leu 
        115                 120                 125             


Arg Asp Val Asp Gly Gly Val Asp Val Thr Phe Ala Thr Thr Asp Ala 
    130                 135                 140                 


Ser Thr Leu Val Gln Val Gly Ala Val Pro Lys Ala Val Ser Leu Asn 
145                 150                 155                 160 


Glu Leu Arg Phe Ser Gln Gly Arg His Gly Trp Arg Cys Ala Val Thr 
                165                 170                 175     


Leu Asp Val 
            


<210>  43
<211>  136
<212>  PRT
<213>  Thermotoga maritima


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Xaa Gly Ser Asp Lys Ile His His His His His His Xaa Arg Lys Pro 
1               5                   10                  15      


Ile Glu His Thr Ala Asp Ile Ala Tyr Glu Ile Ser Gly Asn Ser Tyr 
            20                  25                  30          


Glu Glu Leu Leu Glu Glu Ala Arg Asn Ile Leu Leu Glu Glu Glu Gly 
        35                  40                  45              


Ile Val Leu Asp Thr Glu Glu Lys Glu Lys Xaa Tyr Pro Leu Glu Glu 
    50                  55                  60                  


Thr Glu Asp Ala Phe Phe Asp Thr Val Asn Asp Trp Ile Leu Glu Ile 
65                  70                  75                  80  


Ser Lys Gly Trp Ala Pro Trp Arg Ile Lys Arg Glu Gly Asn Glu Leu 
                85                  90                  95      


Lys Val Thr Phe Arg Lys Ile Arg Lys Lys Glu Gly Thr Glu Ile Lys 
            100                 105                 110         


Ala Leu Thr Tyr His Leu Leu Lys Phe Glu Arg Asp Gly Asp Val Leu 
        115                 120                 125             


Lys Thr Lys Val Val Phe Asp Thr 
    130                 135     


<210>  44
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Lys Gly Gly Ser Arg Val Ser Asn Pro Ala Val Met Ala Gln Glu 
1               5                   10                  15      


Glu Glu Asp Val Arg Asp Tyr Asn Leu Thr Glu Glu Gln Lys Ala Ile 
            20                  25                  30          


Lys Ala Lys Tyr Pro Pro Val Asn Arg Lys Tyr Glu Tyr Leu Asp His 
        35                  40                  45              


Thr Ala Asp Val Gln Leu His Ala Trp Gly Asp Thr Leu Glu Glu Ala 
    50                  55                  60                  


Phe Glu Gln Cys Ala Met Ala Met Phe Gly Tyr Met Thr Asp Thr Gly 
65                  70                  75                  80  


Thr Val Glu Pro Leu Gln Thr Val Glu Val Glu Thr Gln Gly Asp Asp 
                85                  90                  95      


Leu Gln Ser Leu Leu Phe His Phe Leu Asp Glu Trp Leu Tyr Lys Phe 
            100                 105                 110         


Ser Ala Asp Glu Phe Phe Ile Pro Arg Glu Val Lys Val Leu Ser Ile 
        115                 120                 125             


Asp Gln Arg Asn Phe Lys Leu Arg Ser Ile Gly Trp Gly Glu Glu Phe 
    130                 135                 140                 


Ser Leu Ser Lys His Pro Gln Gly Thr Glu Val Lys Ala Ile Thr Tyr 
145                 150                 155                 160 


Ser Ala Met Gln Val Tyr Asn Glu Glu Asn Pro Glu Val Phe Val Ile 
                165                 170                 175     


Ile Asp Ile 
            


<210>  45
<211>  717
<212>  DNA
<213>  Homo sapiens

<400>  45
ccgggccgaa gtccggtgga tgaagggcgg aagtagagtg tctaatcctg cagtcatggc     60

gcaggaagag gaagatgtta gagattacaa tttgactgaa gaacagaagg cgatcaaggc    120

caagtatccg ccagtcaata ggaagtacga gtatttggat catacagcag atgtccagtt    180

acacgcatgg ggagatactc tggaggaagc atttgagcaa tgtgcaatgg ccatgtttgg    240

ttacatgaca gatactggga cagtggagcc cctccaaaca gtagaagtag aaacccaagg    300

agatgactta cagtctcttc tgtttcactt tttggatgaa tggctttata agttcagtgc    360

tgatgaattc ttcatacccc gggaagtgaa agtacttagc attgatcaaa gaaatttcaa    420

attacgatca attgggtggg gagaagaatt ttcattgtcc aagcaccctc agggaacaga    480

agtcaaagca ataacatatt cagcaatgca ggtctataat gaagagaacc cggaagtttt    540

tgtgatcatt gacatttaag acaccaaaaa ataaaagact cctacgaaga actgtttttg    600

ttttcctctt ccttttgaga agacactatg aattaaattc tacagctttt ttttgatata    660

tggaaatttg tagaacagaa atattttagt taaagtgtga ctttcagaaa gggaaaa       717


<210>  46
<211>  2081
<212>  DNA
<213>  Homo sapiens

<400>  46
gttgctcatc tgctgcggcg ctggtcgcgc ctgcgctttg gttcttggaa ggcggtgctc     60

tgagaagccg gactacgcgg cagcggctct tcaaagcgga gccgggagtt tttgctacag    120

ttttcgccac catgagtcgc agctataatg atgagctgca gttcttggag aagatcaata    180

aaaactgctg gaggatcaag aagggcttcg tgcccaacat gcaggttgaa ggtgttttct    240

atgtgaatga tgctctggag aaattgatgt ttgaggaatt aaggaatgcc tgtcgaggtg    300

gtggtgttgg tggcttcctg ccagccatga aacagattgg caatgtggca gccctgcctg    360

gaattgttca tcgatctatt gggcttcctg atgtccattc aggatatggg tttgctattg    420

ggaacatggc agcctttgat atgaatgacc ctgaagcagt agtatcccca ggtggtgtcg    480

ggtttgacat caactgtggt gtccgcttgc taagaaccaa tttagatgaa agtgatgtcc    540

agcctgtgaa ggagcaactt gcccaagcta tgtttgacca cattcctgtt ggggtggggt    600

caaaaggtgt catcccaatg aatgccaaag acttggagga ggccttggag atgggggtgg    660

actggtcctt aagagaaggg tatgcctggg ctgaagacaa ggagcactgc gaggagtacg    720

gaaggatgct gcaggctgac cccaataaag tttctgcaag ggcgaagaaa agaggccttc    780

ctcagttggg gaccctggga gcaggcaacc attatgcaga aatccaggtt gtggatgaga    840

ttttcaatga gtatgctgct aaaaaaatgg gcatcgacca taagggacag gtgtgtgtga    900

tgatccacag tggaagcaga ggcttgggcc accaagtagc cacagatgcg ctggtagcta    960

tggagaaggc catgaagaga gacaagatta tagtcaatga tcggcagttg gcttgtgctc   1020

gaatcgcttc cccagagggt caagactatc tgaagggaat ggcagctgct gggaactatg   1080

cctgggtcaa ccgctcttcc atgaccttct taacccgtca ggctttcgcc aaggtcttca   1140

acacaacccc tgatgacttg gacctacatg tgatctatga tgtttctcac aacattgcca   1200

aagtggagca gcatgtggtg gacggaaagg aacggacact gttagtacac aggaagggat   1260

ccacccgcgc tttccctcct caccatcccc tcattgctgt tgattaccaa ctcactggac   1320

agccagtgct cattggtggc accatgggaa cctgtagtta tgttcttact ggcactgaac   1380

agggcatgac tgagaccttt ggaacaacct gtcatggagc gggccgtgca ttgtcccgag   1440

caaaatctcg acgtaattta gatttccagg atgtcttaga caaattggca gatatgggaa   1500

ttgcgatccg tgttgcctca cccaaactgg ttatggaaga ggctcctgag tcctataaga   1560

atgtgacaga tgtggtaaat acctgccatg atgctggaat cagcaagaaa gccattaaac   1620

tgagaccaat tgctgtgatc aaaggataga accttggaca gcagggctgc ctgacaccac   1680

caaccctctc tgaagtggaa gtggactgac atgctcttct gacatcagac tcaaggcggg   1740

acaagttgca aagtgtgcag ctgtaactgc tcacgccaaa atggctgatg gggaggctgc   1800

tgctttcagg ggcccgtgct tgtaaaataa ccttccagga agaggcacat tgcccacctt   1860

tggaaaggga ggaatatgcc ttctccttgg ttgttccaca gagttttagg aaaatctgtt   1920

agggatgggt agatgtcaaa ctgccttacg cagtcatact gatctttagc catcagattg   1980

atcttcttca caccaagctc tgtttacatt ccgagaggtg tcatgaagaa agttctgttc   2040

aataaggttt tggaatgttt cctttcaaaa aaaaaaaaaa a                       2081


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA (sense strand)

<400>  47
ugacauuuaa gacaccaaat t                                               21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA (antisense strand)

<400>  48
uuuggugucu uaaaugucat t                                               21


