                         SEQUENCE LISTING

<110>  ThromboGenics NV
 
<120>  Anti-PDGF-C antibodies

<130>  TG-055

<150>  EP 12165314.1
<151>  2012-04-24

<150>  US 61/637,372
<151>  2012-04-24

<150>  EP 12192943.4
<151>  2012-11-16

<150>  US 61/727,231
<151>  2012-11-16

<160>  113   

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  1
atgaagttgc ctgttaggct gttg                                              24


<210>  2
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  2
gctcactgga tggtgggaag atgg                                              24


<210>  3
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  3
atggayttyg ggctgakytt kdtt                                              24


<210>  4
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  4
casaymcagg ggccagtgga tagac                                             25


<210>  5
<211>  16
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  5
gtaaaacgac ggccag                                                       16


<210>  6
<211>  17
<212>  DNA
<213>  artificial

<220>
<223>  synthetic oligonucleotide

<400>  6
caggaaacag ctatgac                                                      17


<210>  7
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  7

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu 
1               5                   10      


<210>  9
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  9
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctaatca gascattgta catagtaatg gagacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaak ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

cccacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  10
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  10
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaccattgta catagtgatg gaaccaccta tttagaatgg      120

taccttcaga aagcaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

cccacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  11
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  11
gaggtgcagc tggtggartc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt aactatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attggtagtg gtggtagtta cacctactat      180

ccrgacagtg tgaaggggcg attcaccatc tccagagaca gtgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacaggcc      300

cccctctggg actactctga ctactggggc caaggcacca ctctcactgt ctcctcg         357


<210>  12
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  12
gaggtgcagc tggtggaatc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt aactatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attggtagtg gtggtcatta cacctactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca gtgccaagag caccctgtac      240

ctgcaaatga gcagtctgar gtctgasgac acagccatat attactgtgc aagacaggcc      300

cccctctggg actgctctga ctactggggc caaggcacca ctctcactgt ctcctcg         357


<210>  13
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  13
gaggtgcagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attggttatg gtggtagttt cacctactat      180

ccagatagta tgaaggggcg cttcaccatc tccagagaca atgccaagaa caccctgttc      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatat attactgtgt aagacaggcc      300

cccctctggg actactttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  14
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  14

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Asn Gln Thr Ile Val His Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  15

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Asn Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  16
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Thr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Ala Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Asn Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  18
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ala Pro Leu Trp Asp Tyr Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  19
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Gly Gly His Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ala Pro Leu Trp Asp Cys Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  20
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Tyr Gly Gly Ser Phe Thr Tyr Tyr Pro Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gln Ala Pro Leu Trp Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  21
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Gly Gly His Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ala Pro Leu Trp Asp Cys Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  22
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  22

Arg Ser Asn Gln Ser Ile Val His Ser Asn Gly Asp Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  23

Arg Ser Ser Gln Thr Ile Val His Ser Asp Gly Thr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  24
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  24

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  25

Phe Gln Gly Ser His Val Pro Pro Thr 
1               5                   


<210>  26
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Ser or Thr

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa can be Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be Asp or Thr

<400>  26

Arg Ser Ser Gln Xaa Ile Val His Ser Xaa Gly Xaa Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  27
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  27

Asn Tyr Gly Met Ser 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  28

Ser Tyr Gly Met Ser 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  29

Thr Ile Gly Ser Gly Gly His Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  30

Thr Ile Gly Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  31

Thr Ile Gly Tyr Gly Gly Ser Phe Thr Tyr Tyr Pro Asp Ser Met Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  32

Gln Ala Pro Leu Trp Asp Cys Ser Asp Tyr 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  33

Gln Ala Pro Leu Trp Asp Tyr Ser Asp Tyr 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  34

Gln Ala Pro Leu Trp Asp Tyr Phe Asp Tyr 
1               5                   10  


<210>  35
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Asn or Ser

<400>  35

Xaa Tyr Gly Met Ser 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be Ser or Tyr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Ser or His

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa can be Val or Met

<400>  36

Thr Ile Gly Xaa Gly Gly Xaa Xaa Thr Tyr Tyr Pro Asp Ser Xaa Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be Cys or Thr

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be Ser or Phe

<400>  37

Gln Ala Pro Leu Trp Asp Xaa Xaa Asp Tyr 
1               5                   10  


<210>  38
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  38

Arg Ser Asn Gln Thr Ile Val His Ser Asn Gly Asp Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  39
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  39

Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe Ser Ser Asn Lys Glu 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  40

Ser Lys Phe Gln Phe Ser Ser Asn Lys Glu Gln Asn Gly Val Gln 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  41

Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln His Glu 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  42

Gln Asn Gly Val Gln Asp Pro Gln His Glu Arg Ile Ile Thr Val 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  43

Asp Pro Gln His Glu Arg Ile Ile Thr Val Ser Thr Asn Gly Ser 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  44

Arg Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser Pro Arg 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  45

Ser Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro His Thr Tyr 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  46

Ile His Ser Pro Arg Phe Pro His Thr Tyr Pro Arg Asn Thr Val 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  47

Phe Pro His Thr Tyr Pro Arg Asn Thr Val Leu Val Trp Arg Leu 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  48

Pro Arg Asn Thr Val Leu Val Trp Arg Leu Val Ala Val Glu Glu 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  49

Leu Val Trp Arg Leu Val Ala Val Glu Glu Asn Val Trp Ile Gln 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  50

Val Ala Val Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  51

Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu Glu 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  52

Leu Thr Phe Asp Glu Arg Phe Gly Leu Glu Asp Pro Glu Asp Asp 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  53

Arg Phe Gly Leu Glu Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  54

Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  55

Ile Cys Lys Tyr Asp Phe Val Glu Val Glu Glu Pro Ser Asp Gly 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  56

Phe Val Glu Val Glu Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  57

Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly 
1               5                   10                  15  


<210>  58
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  58

Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr Val Pro Gly Lys 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  59

Trp Cys Gly Ser Gly Thr Val Pro Gly Lys Gln Ile Ser Lys Gly 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  60

Thr Val Pro Gly Lys Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  61

Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe Val Ser Asp 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  62

Asn Gln Ile Arg Ile Arg Phe Val Ser Asp Glu Tyr Phe Pro Ser 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  63

Arg Phe Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  64

Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr Asn Ile 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  65

Glu Pro Gly Phe Cys Ile His Tyr Asn Ile Val Met Pro Gln Phe 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  66

Ile His Tyr Asn Ile Val Met Pro Gln Phe Thr Glu Ala Val Ser 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  67

Val Met Pro Gln Phe Thr Glu Ala Val Ser Pro Ser Val Leu Pro 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  68

Thr Glu Ala Val Ser Pro Ser Val Leu Pro Pro Ser Ala Leu Pro 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  69

Pro Ser Val Leu Pro Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  70

Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  71

Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala Phe Ser Thr Leu Glu 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  72

Asn Ala Ile Thr Ala Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  73

Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  74

Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp Gln Leu Asp Leu 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  75

Leu Glu Pro Glu Arg Trp Gln Leu Asp Leu Glu Asp Leu Tyr Arg 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  76

Trp Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  77

Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly Lys Ala Phe 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  78

Pro Thr Trp Gln Leu Leu Gly Lys Ala Phe Val Phe Gly Arg Lys 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  79

Leu Gly Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  80

Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu Leu Thr 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  81

Ser Arg Val Val Asp Leu Asn Leu Leu Thr Glu Glu Val Arg Leu 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  82

Leu Asn Leu Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  83

Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser Val 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  84

Tyr Ser Cys Thr Pro Arg Asn Phe Ser Val Ser Ile Arg Glu Glu 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  85

Arg Asn Phe Ser Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  86

Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  87

Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro Gly Cys Leu Leu Val 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  88

Thr Ile Phe Trp Pro Gly Cys Leu Leu Val Lys Arg Cys Gly Gly 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  89

Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  90

Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu His Asn Cys Asn 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  91

Asn Cys Ala Cys Cys Leu His Asn Cys Asn Glu Cys Gln Cys Val 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  92

Leu His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys Val Thr 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  93

Glu Cys Gln Cys Val Pro Ser Lys Val Thr Lys Lys Tyr His Glu 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  94

Pro Ser Lys Val Thr Lys Lys Tyr His Glu Val Leu Gln Leu Arg 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  95

Lys Lys Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr Gly Val 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  96

Val Leu Gln Leu Arg Pro Lys Thr Gly Val Arg Gly Leu His Lys 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  97

Pro Lys Thr Gly Val Arg Gly Leu His Lys Ser Leu Thr Asp Val 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  98

Arg Gly Leu His Lys Ser Leu Thr Asp Val Ala Leu Glu His His 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  99

Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp Cys 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  100

Ala Leu Glu His His Glu Glu Cys Asp Cys Val Cys Arg Gly Ser 
1               5                   10                  15  


<210>  101
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide

<400>  101

Glu Glu Cys Asp Cys Val Cys Arg Gly Ser Thr Gly Gly 
1               5                   10              


<210>  102
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized variable heavy chain murine monoclonal antibody 5H7

<400>  102

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Tyr Gly Gly Ser Phe Thr Tyr Tyr Pro Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ala Pro Leu Trp Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Leu Thr Val Ser Ser 
        115                 


<210>  103
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized variable light chain murine monoclonal antibody 5H7

<400>  103

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Thr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  104
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized variable heavy chain murine monoclonal antibody 16B1

<400>  104

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ala Pro Leu Trp Asp Tyr Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Leu Thr Val Ser Ser 
        115                 


<210>  105
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized variable light chain murine monoclonal antibody 16B1

<400>  105

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Asn Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  106
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  humanized variable heavy chain murine monoclonal antibody 29 H1

<400>  106

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Gly Ser Gly Gly His Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Ala Pro Leu Trp Asp Cys Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Leu Thr Val Ser Ser 
        115                 


<210>  107
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  humanized variable light chain murine monoclonal antibody 29 H1

<400>  107

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Asp Gly Thr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  108
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  humanized variable heavy chain murine monoclonal antibody 5H7

<400>  108
gaggtgcagc ttctggaatc tgggggaggt cttgtgcagc caggagggtc cctgcggctc       60

tcctgtgccg catctggatt cactttcagt agctatggca tgtcttgggt tcgccagact      120

cctggcaaag ggctggagtg ggtcgcaacc attggctatg gtgggagttt cacctactat      180

ccagattcaa tgaagggacg ctttaccatc agcagagaca atgccaagaa caccttgtac      240

ctgcaaatga acagtctgcg agccgaagac acagccgtgt actattgcgc taggcaggct      300

cccctctggg actactttga ttactggggc caaggcacat tgctcacagt ctcctca         357


<210>  109
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  humanized variable light chain murine monoclonal antibody 5H7

<400>  109
gacgttgtga tgacccaatc tcccttgtcc ctgcctgtca ctcttgggca gcctgcctcc       60

attagctgtc gctctagcca gaccattgtg catagtgacg gcacaaccta cctggaatgg      120

tatcttcaga aaccaggcca gagcccacgg ctcctgatct acaaagtttc caacaggttt      180

agtggggtcc cagacaggtt ctccggcagt ggatcaggga cagatttcac actcaagata      240

agcagagtgg aggctgagga tgtgggagtc tactattgct ttcaaggttc acacgtacct      300

cccactttcg gccagggaac caagctggaa atcaag                                336


<210>  110
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  humanized variable heavy chain murine monoclonal antibody 16B1

<400>  110
gaggtgcagc ttctggaatc tgggggaggt cttgtgcagc caggagggtc cctgcggctc       60

tcctgtgccg catctggatt cactttcagt aattatggca tgtcttgggt tcgccagact      120

cctggcaaag ggctggagtg ggtcgcaacc attggcagtg gtgggagtta tacctactat      180

ccagattcag tgaagggacg ctttaccatc agcagagaca atgccaagaa caccttgtac      240

ctgcaaatga acagtctgcg agccgaagac acagccgtgt actattgcgc taggcaggct      300

cccctctggg actacagcga ttactggggc caaggcacat tgctcacagt ctcctca         357


<210>  111
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  humanized variable light chain murine monoclonal antibody 16B1

<400>  111
gacgttgtga tgacccaatc tcccttgtcc ctgcctgtca ctcttgggca gcctgcctcc       60

attagctgtc gctctaacca gagcattgtg catagtaacg gcgacaccta cctggaatgg      120

tatcttcaga aaccaggcca gagcccacgg ctcctgatct acaaagtttc caacaggttt      180

agtggggtcc cagacaggtt ctccggcagt ggatcaggga cagatttcac actcaagata      240

agcagagtgg aggctgagga tgtgggagtc tactattgct ttcaaggttc acacgtacct      300

cccactttcg gccagggaac caagctggaa atcaag                                336


<210>  112
<211>  357
<212>  DNA
<213>  artificial

<220>
<223>  humanized variable heavy chain murine monoclonal antibody 29 H1

<400>  112
gaggtgcagc ttctggaatc tgggggaggt cttgtgcagc caggagggtc cctgcggctc       60

tcctgtgccg catctggatt cactttcagt aattatggca tgtcttgggt tcgccagact      120

cctggcaaag ggctggagtg ggtcgcaacc attggcagtg gtgggcacta tacctactat      180

ccagattcag tgaagggacg ctttaccatc agcagagaca atgccaagaa caccttgtac      240

ctgcaaatga acagtctgcg agccgaagac acagccgtgt actattgcgc taggcaggct      300

cccctctggg actgtagcga ttactggggc caaggcacat tgctcacagt ctcctca         357


<210>  113
<211>  336
<212>  DNA
<213>  artificial

<220>
<223>  humanized variable light chain murine monoclonal antibody 29 H1

<400>  113
gacgttgtga tgacccaatc tcccttgtcc ctgcctgtca ctcttgggca gcctgcctcc       60

attagctgtc gctctagcca gaccattgtg catagtgacg gcacaaccta cctggaatgg      120

tatcttcaga aaccaggcca gagcccacgg ctcctgatct acaaagtttc caacaggttt      180

agtggggtcc cagacaggtt ctccggcagt ggatcaggga cagatttcac actcaagata      240

agcagagtgg aggctgagga tgtgggagtc tactattgct ttcaaggttc acacgtacct      300

cccactttcg gccagggaac caagctggaa atcaag                                336


