                         SEQUENCE LISTING

<110>  ALBERT EINSTEIN COLLGE OF MEDICINE OF YESHIVA UNIVERSITY
 
<120>  TRANSFERRIN RECEPTOR APTAMERS AND APTAMER-TARGETED DELIVERY

<130>  96700/1985

<140>  pct/us13/038006
<141>  2013-04-24

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  93
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  1
gggaggugaa ugguucuacg auaaacgguu aaugaccagc uuauggcugg caguuccuau       60

agcaccaacu acaugcgaga ugaccacgua aug                                    93


<210>  2
<211>  64
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  2
gggugaaugg uucuacgaua aacgguuaau gaccagcuua uggcuggcag uuccuauagc       60

accc                                                                    64


<210>  3
<211>  53
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  3
gggaguucua cgauaaacgg uuaaugacca gcuuauggcu ggcaguuccu ccc              53


<210>  4
<211>  44
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  4
gggaguucua guuaaugacc agcuuauggc uggcaguucc uccc                        44


<210>  5
<211>  33
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  5
ggguuaauga ccagcuuaug gcuggcaguu ccc                                    33


<210>  6
<211>  66
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  6
gggugaaugg uucuacgaua aacggguuaa ugaccagcuu auggcuggca guucccuaua       60

gcaccc                                                                  66


<210>  7
<211>  57
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  7
gggugaaugg uucuacgaua aacgguuaau gaccgaaagg caguuccuau agcaccc          57


<210>  8
<211>  56
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  8
gggugaauca uaaacgguua augaccagcu uauggcuggc aguuccuaca gcaccc           56


<210>  9
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  9
gggugaaugg uucuacgaua aacggcuuaa uaguugccua uagcaccc                    48


<210>  10
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  10
ggguucuacg auaaacgguu aaugaccagc uuauggcugg caguuccc                    48


<210>  11
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  11
gggaacuacg auaaacgguu aaugaccagc uuauggcugg caguuccc                    48


<210>  12
<211>  42
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  12
ggguacgaua aacgguuaau gaccagcuua uggcuggcac cc                          42


<210>  13
<211>  42
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  13
ggguacgaua aacgguuaag gaccagcuua uggcuggccc cc                          42


<210>  14
<211>  42
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  14
ggguacgaca aacggucaau gaccagcuua uggcuggcac cc                          42


<210>  15
<211>  121
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ENCODING PORTION OF HUMAN TRANSFERRIN RECEPTOR


<220>
<221>  misc_feature
<222>  (23)..(72)
<223>  n = A, T, G or C

<400>  15
gggaggtgaa tggttctacg atnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnttacatgc gagatgacca cgtaattgaa ttaaatgccc gccatgacca      120

g                                                                      121


<210>  16
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO TRANSFERRIN

<400>  16
ctggtcatgg cgggcattta attc                                              24


<210>  17
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  RNA aptamer constant region

<400>  17
gaattaaatg cccgccatga ccag                                              24


<210>  18
<211>  44
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APATAMR DIRECTED TO HUMAN TRANSFERRIN

<400>  18
gggggaucaa uccaagggac ccggaaacgc ucccuuacac ccct                        44


<210>  19
<211>  37
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER DIRECTED TO HUMAN TRANSFERRIN

<400>  19
ggcguaguga uuaugaaucg ugugcuaaua cacgcct                                37


<210>  20
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN TRANSFERRIN

<400>  20
gacaaccact acctgagcac                                                   20


<210>  21
<211>  18
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN TRANSFERRIN

<400>  21
caggaccatg tgatcgcg                                                     18


<210>  22
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN TRANSFERRIN

<400>  22
cctgagcaaa gaccccaacg agaa                                              24


<210>  23
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN TRANSFERRIN

<400>  23
atgatcgctt ggcggtctac                                                   20


<210>  24
<211>  18
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN TRANSFERRIN

<400>  24
gccctgcgtt ctccgttt                                                     18


<210>  25
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN TRANSFERRIN

<400>  25
tcgaccgtgt gcgctcgctg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN TRANSFERRIN

<400>  26
ggcgacctgg aagtccaact                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN TRANSFERRIN

<400>  27
ccatcagcac cacagccttc                                                   20


<210>  28
<211>  25
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN TRANSFERRIN

<400>  28
atctgctgca tctgcttgga gccca                                             25


<210>  29
<211>  50
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL PRIMER

<400>  29
ucaaacaucu cacagaucaa uccaagggac cucguuaaag gacgacuccc                  50


<210>  30
<211>  51
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  30
uagguuagcc gcagaucacu acaaagcccc uagagcacau gcuccaccgc u                51


<210>  31
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  31
cauuacggcu accccgugua acgucagcca aaguagacca aaagucag                    48


<210>  32
<211>  50
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  32
acgcauggca ggaagcaugu uauccccuaa gaauccgcaa ucgcucguaa                  50


<210>  33
<211>  50
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  33
cagaugacaa agcgcaucag aagaauaaag ugagauaaag ugugagaggg                  50


<210>  34
<211>  50
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  34
uuugugaccu ggucagggag uugaaggguc gcucuuuuga aaagccuugg                  50


<210>  35
<211>  52
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  35
ccgcgaaacu uaaaaaaaac gacaaacgcg ugagccgggc aagguaggua uu               52


<210>  36
<211>  66
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  36
aguagcuuga aaucagaaaa ccgacgaaac aaaaaauaug auuuagcaag gaugaccacg       60

uaauug                                                                  66


<210>  37
<211>  49
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  37
agggugaaau ugcgagcguu gcccaacuuu auaaguuggu gaauagcca                   49


<210>  38
<211>  50
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  38
acaaguaucg guuuuacaau acagacguac agugcgauag ccaagcggaa                  50


<210>  39
<211>  92
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  39
gggaggugaa uggucuacga uucaaacauc ucacagauca auccaaggga ccucguuaaa       60

ggacgacucc cuuacaugcg agaugaccac gu                                     92


<210>  40
<211>  96
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  40
gggaggugaa ugguucuacg auuagguuag ccgcagauca cuacaaagcc ccuagagcac       60

augcuccacc gcuuuacaug ccgagaugac caccgu                                 96


<210>  41
<211>  91
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  41
gggaggugaa ugguucuacg aucauuacgg cuaccccgug uaacgucagc caaaguagac       60

caaaagucag uuacaugcga gaugaccacg u                                      91


<210>  42
<211>  30
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  42
ggggaccucg uuaaaggacg acuccccuuu                                        30


<210>  43
<211>  64
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  43
gggagcaucu cacagaucaa uccaagggac cucguuaaag gacgacyccc uuacaugcga       60

gaug                                                                    64


<210>  44
<211>  35
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  44
gggaagggac cucguuaaag gacgacuccc uuaca                                  35


<210>  45
<211>  52
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  45
gggagcaucu cacagaucaa uccaagggac cuacucccuu acaugcgaga ug               52


<210>  46
<211>  50
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  46
gggagcaucu cacagaucaa uccaagggga aaucccuuac augcgagaug                  50


<210>  47
<211>  55
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  47
ggggacagau caauccaagg gaccucguua aaggacgacu cccuuacaug ucccc            55


<210>  48
<211>  45
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  48
gggggaucaa uccaagggac cucggaaacg acucccuuac acccc                       45


<210>  49
<211>  51
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  49
ggggacagau caauuccggc uaccccgugu aacgucuagc cacauguccc c                51


<210>  50
<211>  43
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  50
gggggaucaa uccaagggac ccggaaacgc ucccuuacac ccc                         43


<210>  51
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  51
ggguucuacg auaaacgguu aaugaucagc uuauggcugg caguuccc                    48


<210>  52
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  52
ugguucuacg auaaacgguu aaugaucagc uuauggcugg caguuccu                    48


<210>  53
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  53
ugguucuacg auaaacgguu aaugaucagc uuaugacugg caguuccu                    48


<210>  54
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  54
ugauuguacg auaaacgguu aaugaucagc uuauggaugg caguuccu                    48


<210>  55
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  55
ugguucuacg auaaacgguu aauggucagc uuauggcugg caguuccu                    48


<210>  56
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  56
ugguucuacg auaaacgguu aaugaccsgc uuauggcugg caguuccu                    48


<210>  57
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  57
ugguucuacg auaaacgguu aaugaucagc uuauggccgg caguuccu                    48


<210>  58
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  58
ggguucuacg auaaacgguu aaugaccagc uuaugacugg caguuccc                    48


<210>  59
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  59
ggguucuacg acaaacgguu aaugaucagc uuauggcugg caguuccc                    48


<210>  60
<211>  48
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER

<400>  60
ggguuuuacg auaaacgguu aaugaucagc uuaagacugg caauuccc                    48


<210>  61
<211>  9
<212>  RNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  ARTIFICIAL APTAMER


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Y = U OR C

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  M = A OR C

<400>  61
gaucayumc                                                                9


<210>  62
<211>  22
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN INTERFERON

<400>  62
agacttacag gttacctccg aa                                                22


<210>  63
<211>  21
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN INTERFERON

<400>  63
cagtacattc gccatcagtc a                                                 21


<210>  64
<211>  23
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN OAS1

<400>  64
cgagggagca tgaaaacaca ttt                                               23


<210>  65
<211>  24
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN OAS1

<400>  65
gcagagttgc tggtagttta tgac                                              24


<210>  66
<211>  22
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN CDKL2

<400>  66
gcctccttgg gttcgtctat aa                                                22


<210>  67
<211>  20
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  PRIMER DIRECTED TO HUMAN CDKL2

<400>  67
ctcagggccc gctcatagta                                                   20


