                         SEQUENCE LISTING

<110>  The Sydney Children's Hospitals Network
       The University of Sydney
 
<120>  Vaccine and uses thereof

<130>  513438

<150>  AU 2012901774
<151>  2012-05-01

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  6936
<212>  DNA
<213>  Homo sapiens

<400>  1
aggccgcgct cagcaggcgg ggcgggagcc gcgtgcgccc gaggacccgg ccggaaggct       60

tgcgccagct caggatgagg acaggctggg cgacccctcg ccgcccggcg gggctcctca      120

tgctgctctt ctggttcttc gatctcgcgg agccctctgg ccgcgcagct aatgacccct      180

tcaccatcgt ccatggaaat acgggcaagt gcatcaagcc agtgtatggc tggatagtag      240

cagacgactg tgatgaaact gaggacaagt tatggaagtg ggtgtcccag catcggctct      300

ttcatttgca ctcccaaaag tgccttggcc tcgatattac caaatcggta aatgagctga      360

gaatgttcag ctgtgactcc agtgccatgc tgtggtggaa atgtgagcac cactctctgt      420

acggagctgc ccggtaccgg ctggctctga aggatggaca tggcacagca atctcaaatg      480

catctgatgt ctggaagaaa ggaggctcag aggaaagcct ttgtgaccag ccttatcatg      540

agatctatac cagagatggg aactcttatg ggagaccttg tgaatttcca ttcttaattg      600

atgggacctg gcatcatgat tgcattcttg atgaagatca tagtgggcca tggtgtgcca      660

ccaccttaaa ttatgaatat gaccgaaagt ggggcatctg cttaaagcct gaaaacggtt      720

gtgaagataa ttgggaaaag aacgagcagt ttggaagttg ctaccaattt aatactcaga      780

cggctctttc ttggaaagaa gcttatgttt catgtcagaa tcaaggagct gatttactga      840

gcatcaacag tgctgctgaa ttaacttacc ttaaagaaaa agaaggcatt gctaagattt      900

tctggattgg tttaaatcag ctatactctg ctagaggctg ggaatggtca gaccacaaac      960

cattaaactt tctcaactgg gatccagaca ggcccagtgc acctactata ggtggctcca     1020

gctgtgcaag aatggatgct gagtctggtc tgtggcagag cttttcctgt gaagctcaac     1080

tgccctatgt ctgcaggaaa ccattaaata atacagtgga gttaacagat gtctggacat     1140

actcagatac ccgctgtgat gcaggctggc tgccaaataa tggattttgc tatctgctgg     1200

taaatgaaag taattcctgg gataaggcac atgcgaaatg caaagccttc agtagtgacc     1260

taatcagcat tcattctcta gcagatgtgg aggtggttgt cacaaaactc cataatgagg     1320

atatcaaaga agaagtgtgg ataggcctta agaacataaa cataccaact ttatttcagt     1380

ggtcagatgg tactgaagtt actctaacat attgggatga gaatgagcca aatgttccct     1440

acaataagac gcccaactgt gtttcctact taggagagct aggtcagtgg aaagtccaat     1500

catgtgagga gaaactaaaa tatgtatgca agagaaaggg agaaaaactg aatgacgcaa     1560

gttctgataa gatgtgtcct ccagatgagg gctggaagag acatggagaa acctgttaca     1620

agatttatga ggatgaggtc ccttttggaa caaactgcaa tctgactatc actagcagat     1680

ttgagcaaga atacctaaat gatttgatga aaaagtatga taaatctcta agaaaatact     1740

tctggactgg cctgagagat gtagattctt gtggagagta taactgggca actgttggtg     1800

gaagaaggcg ggctgtaacc ttttccaact ggaattttct tgagccagct tccccgggcg     1860

gctgcgtggc tatgtctact ggaaagtctg ttggaaagtg ggaggtgaag gactgcagaa     1920

gcttcaaagc actttcaatt tgcaagaaaa tgagtggacc ccttgggcct gaagaagcat     1980

cccctaagcc tgatgacccc tgtcctgaag gctggcagag tttccccgca agtctttctt     2040

gttataaggt attccatgca gaaagaattg taagaaagag gaactgggaa gaagctgaac     2100

gattctgcca agcccttgga gcacaccttt ctagcttcag ccatgtggat gaaataaagg     2160

aatttcttca ctttttaacg gaccagttca gtggccagca ttggctgtgg attggtttga     2220

ataaaaggag cccagattta caaggatcct ggcaatggag tgatcgtaca ccagtgtcta     2280

ctattatcat gccaaatgag tttcagcagg attatgacat cagagactgt gctgctgtca     2340

aggtatttca taggccatgg cgaagaggct ggcatttcta tgatgataga gaatttattt     2400

atttgaggcc ttttgcttgt gatacaaaac ttgaatgggt gtgccaaatt ccaaaaggcc     2460

gtactccaaa aacaccagac tggtacaatc cagaccgtgc tggaattcat ggacctccac     2520

ttataattga aggaagtgaa tattggtttg ttgctgatct tcacctaaac tatgaagaag     2580

ccgtcctgta ctgtgccagc aatcacagct ttcttgcaac tataacatct tttgtgggac     2640

taaaagccat caaaaacaaa atagcaaata tatctggtga tggacagaag tggtggataa     2700

gaattagcga gtggccaata gatgatcatt ttacatactc acgatatcca tggcaccgct     2760

ttcctgtgac atttggagag gaatgcttgt acatgtctgc caagacttgg cttatcgact     2820

taggtaaacc aacagactgt agtaccaagt tgcccttcat ctgtgaaaaa tataatgttt     2880

cttcgttaga gaaatacagc ccagattctg cagctaaagt gcaatgttct gagcaatgga     2940

ttccttttca gaataagtgt tttctaaaga tcaaacccgt gtctctcaca ttttctcaag     3000

caagcgatac ctgtcactcc tatggtggca cccttccttc agtgttgagc cagattgaac     3060

aagactttat tacatccttg cttccggata tggaagctac tttatggatt ggtttgcgct     3120

ggactgccta tgaaaagata aacaaatgga cagataacag agagctgacg tacagtaact     3180

ttcacccatt attggttagt gggaggctga gaataccaga aaattttttt gaggaagagt     3240

ctcgctacca ctgtgcccta atactcaacc tccaaaaatc accgtttact gggacgtgga     3300

attttacatc ctgcagtgaa cgccactttg tgtctctctg tcagaaatat tcagaagtta     3360

aaagcagaca gacgttgcag aatgcttcag aaactgtaaa gtatctaaat aatctgtaca     3420

aaataatccc aaagactctg acttggcaca gtgctaaaag ggagtgtctg aaaagtaaca     3480

tgcagctggt gagcatcacg gacccttacc agcaggcatt cctcagtgtg caggcgctcc     3540

ttcacaactc ttccttatgg atcggactct tcagtcaaga tgatgaactc aactttggtt     3600

ggtcagatgg gaaacgtctt cattttagtc gctgggctga aactaatggg caactcgaag     3660

actgtgtagt attagacact gatggattct ggaaaacagt tgattgcaat gacaatcaac     3720

caggtgctat ttgctactat tcaggaaatg agactgaaaa agaggtcaaa ccagttgaca     3780

gtgttaaatg tccatctcct gttctaaata ctccgtggat accatttcag aactgttgct     3840

acaatttcat aataacaaag aataggcata tggcaacaac acaggatgaa gttcatacta     3900

aatgccagaa actgaatcca aaatcacata ttctgagtat tcgagatgaa aaggagaata     3960

actttgttct tgagcaactg ctgtacttca attatatggc ttcatgggtc atgttaggaa     4020

taacttatag aaataagtct cttatgtggt ttgataagac cccactgtca tatacacatt     4080

ggagagcagg aagaccaact ataaaaaatg agaagttttt ggctggttta agtactgacg     4140

gcttctggga tattcaaacc tttaaagtta ttgaagaagc agtttatttt caccagcaca     4200

gcattcttgc ttgtaaaatt gaaatggttg actacaaaga agaatataat actacactgc     4260

cacagtttat gccatatgaa gatggtattt acagtgttat tcaaaaaaag gtaacatggt     4320

atgaagcatt aaacatgtgt tctcaaagtg gaggtcactt ggcaagcgtt cacaaccaaa     4380

atggccagct ctttctggaa gatattgtaa aacgtgatgg atttccacta tgggttgggc     4440

tctcaagtca tgatggaagt gaatcaagtt ttgaatggtc tgatggtagt acatttgact     4500

atatcccatg gaaaggccaa acatctcctg gaaattgtgt tctcttggat ccaaaaggaa     4560

cttggaaaca tgaaaaatgc aactctgtta aggatggtgc tatttgttat aaacctacaa     4620

aatctaaaaa gctgtcccgt cttacatatt catcaagatg tccagcagca aaagagaatg     4680

ggtcacggtg gatccagtac aagggtcact gttacaagtc tgatcaggca ttgcacagtt     4740

tttcagaggc caaaaaattg tgttcaaaac atgatcactc tgcaactatc gtttccataa     4800

aagatgaaga tgagaataaa tttgtgagca gactgatgag ggaaaataat aacattacca     4860

tgagagtttg gcttggatta tctcaacatt ctgttgacca gtcttggagt tggttagatg     4920

gatcagaagt gacatttgtc aaatgggaaa ataaaagtaa gagtggtgtt ggaagatgta     4980

gcatgttgat agcttcaaat gaaacttgga aaaaagttga atgtgaacat ggttttggaa     5040

gagttgtctg caaagtgcct ctgggccctg attacacagc aatagctatc atagttgcca     5100

cactaagtat cttagttctc atgggcggac tgatttggtt cctcttccaa aggcaccgtt     5160

tgcacctggc gggtttctca tcagttcgat atgcacaagg agtgaatgaa gatgagatta     5220

tgcttccttc tttccatgac taaattcttc taaaagtttt ctaatttgca ctaatgtgtt     5280

atgagaaatt agtcacttaa aatgtcccag tgtcagtatt tactctgctc caaagtagaa     5340

ctcttaaata ctttttcagt tgtttagatc ttaggcatgt gctggtatcc acagttaatt     5400

ccctgctaaa tgccatgttt atcaccctaa ttaatagaat ggaggggact ccaaagctgg     5460

aactgaagtc caaattgttt gtacagtaat atgtttaatg ttcattttct ctgtatgaat     5520

gtgattggta actaggatat gtatatttta atagaatttt taacaaaact tcttagaaaa     5580

ttaaaatagg catattacta ggtgacatgt ctacttttta atttttaaga gcatccggcc     5640

aaatgcaaaa ttagtacctc aaagtaaaaa ttgaactgta aactctatca gcattgtttc     5700

aaaatagtca tttttagcac tggggaaaaa taaacaataa gacatgctta ctttttaatt     5760

tttatttttt tgagactgag tctctctctg ttgcccaggc tggagtacaa tggcgtgatc     5820

tcggctcact gcaaatctcc gcctcccagg ttcaagcgat tctcctgcct cagcctcctg     5880

agtagctggg attacaggca actgccacca tgcccggcta atttttgtat ttttagtaga     5940

gatggggttt caccatgttg gccaggctgg tctcgaactc gtgaccgcag gtgatcctcc     6000

cgcctcggcc tcccaaagtg ctgggattac aggcatgagc caccgcgcct ggcctctgct     6060

tactttttat atagcaaaat gattcctctt ggcaagatgt ttcttatatt attccaaagt     6120

tatttcatac cattattatg taaatatgaa gagttttttt ctgtttataa ttgtttataa     6180

aacaatgact tttaaagatt tagtgcttaa cattttccca agtgtgggaa cattattttt     6240

agattgagta ggtaccttgt agcagtgtgc tttgcatttt ctgatgtatt acatgactgt     6300

ttcttttgta aagagaatca actaggtatt taagactgat aattttacaa tttatatgct     6360

tcacatagca tgtcaacttt tgactaagaa ttttgtttta cttttttaac atgtgttaaa     6420

cagagaaagg gtccatgaag gaaagtgtat gagttgcatt tgtaaaaatg agactttttc     6480

agtggaactc taaaccttgt gatgactact aacaaatgta aaattatgag tgattaagaa     6540

aacattgctt tgtggttatc actttaagtt ttgacaccta gattatagtc ttagtaatag     6600

catccactgg aaaaggtgaa aatgttttat tcggcattta acttacattt gtactttatt     6660

tttgtataaa atccatagat ttattttaca tttagagtat ttacactatg ataaagttgt     6720

aaataatttt ctaagacagt ttttatatag tctacagttg tcctgatttc ttattgaatt     6780

tgttagacta gttctcttgt cctgtgatct gtgtacaatt ttagtcacta agactttcct     6840

ccaagaacta agccaacttg atgtgaaaag cacagctgta tataatggtg atgtcataat     6900

aaagttgttt tatcttttaa gtaaaagtaa aaaaaa                               6936


<210>  2
<211>  1722
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Thr Gly Trp Ala Thr Pro Arg Arg Pro Ala Gly Leu Leu Met 
1               5                   10                  15      


Leu Leu Phe Trp Phe Phe Asp Leu Ala Glu Pro Ser Gly Arg Ala Ala 
            20                  25                  30          


Asn Asp Pro Phe Thr Ile Val His Gly Asn Thr Gly Lys Cys Ile Lys 
        35                  40                  45              


Pro Val Tyr Gly Trp Ile Val Ala Asp Asp Cys Asp Glu Thr Glu Asp 
    50                  55                  60                  


Lys Leu Trp Lys Trp Val Ser Gln His Arg Leu Phe His Leu His Ser 
65                  70                  75                  80  


Gln Lys Cys Leu Gly Leu Asp Ile Thr Lys Ser Val Asn Glu Leu Arg 
                85                  90                  95      


Met Phe Ser Cys Asp Ser Ser Ala Met Leu Trp Trp Lys Cys Glu His 
            100                 105                 110         


His Ser Leu Tyr Gly Ala Ala Arg Tyr Arg Leu Ala Leu Lys Asp Gly 
        115                 120                 125             


His Gly Thr Ala Ile Ser Asn Ala Ser Asp Val Trp Lys Lys Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ser Leu Cys Asp Gln Pro Tyr His Glu Ile Tyr Thr Arg 
145                 150                 155                 160 


Asp Gly Asn Ser Tyr Gly Arg Pro Cys Glu Phe Pro Phe Leu Ile Asp 
                165                 170                 175     


Gly Thr Trp His His Asp Cys Ile Leu Asp Glu Asp His Ser Gly Pro 
            180                 185                 190         


Trp Cys Ala Thr Thr Leu Asn Tyr Glu Tyr Asp Arg Lys Trp Gly Ile 
        195                 200                 205             


Cys Leu Lys Pro Glu Asn Gly Cys Glu Asp Asn Trp Glu Lys Asn Glu 
    210                 215                 220                 


Gln Phe Gly Ser Cys Tyr Gln Phe Asn Thr Gln Thr Ala Leu Ser Trp 
225                 230                 235                 240 


Lys Glu Ala Tyr Val Ser Cys Gln Asn Gln Gly Ala Asp Leu Leu Ser 
                245                 250                 255     


Ile Asn Ser Ala Ala Glu Leu Thr Tyr Leu Lys Glu Lys Glu Gly Ile 
            260                 265                 270         


Ala Lys Ile Phe Trp Ile Gly Leu Asn Gln Leu Tyr Ser Ala Arg Gly 
        275                 280                 285             


Trp Glu Trp Ser Asp His Lys Pro Leu Asn Phe Leu Asn Trp Asp Pro 
    290                 295                 300                 


Asp Arg Pro Ser Ala Pro Thr Ile Gly Gly Ser Ser Cys Ala Arg Met 
305                 310                 315                 320 


Asp Ala Glu Ser Gly Leu Trp Gln Ser Phe Ser Cys Glu Ala Gln Leu 
                325                 330                 335     


Pro Tyr Val Cys Arg Lys Pro Leu Asn Asn Thr Val Glu Leu Thr Asp 
            340                 345                 350         


Val Trp Thr Tyr Ser Asp Thr Arg Cys Asp Ala Gly Trp Leu Pro Asn 
        355                 360                 365             


Asn Gly Phe Cys Tyr Leu Leu Val Asn Glu Ser Asn Ser Trp Asp Lys 
    370                 375                 380                 


Ala His Ala Lys Cys Lys Ala Phe Ser Ser Asp Leu Ile Ser Ile His 
385                 390                 395                 400 


Ser Leu Ala Asp Val Glu Val Val Val Thr Lys Leu His Asn Glu Asp 
                405                 410                 415     


Ile Lys Glu Glu Val Trp Ile Gly Leu Lys Asn Ile Asn Ile Pro Thr 
            420                 425                 430         


Leu Phe Gln Trp Ser Asp Gly Thr Glu Val Thr Leu Thr Tyr Trp Asp 
        435                 440                 445             


Glu Asn Glu Pro Asn Val Pro Tyr Asn Lys Thr Pro Asn Cys Val Ser 
    450                 455                 460                 


Tyr Leu Gly Glu Leu Gly Gln Trp Lys Val Gln Ser Cys Glu Glu Lys 
465                 470                 475                 480 


Leu Lys Tyr Val Cys Lys Arg Lys Gly Glu Lys Leu Asn Asp Ala Ser 
                485                 490                 495     


Ser Asp Lys Met Cys Pro Pro Asp Glu Gly Trp Lys Arg His Gly Glu 
            500                 505                 510         


Thr Cys Tyr Lys Ile Tyr Glu Asp Glu Val Pro Phe Gly Thr Asn Cys 
        515                 520                 525             


Asn Leu Thr Ile Thr Ser Arg Phe Glu Gln Glu Tyr Leu Asn Asp Leu 
    530                 535                 540                 


Met Lys Lys Tyr Asp Lys Ser Leu Arg Lys Tyr Phe Trp Thr Gly Leu 
545                 550                 555                 560 


Arg Asp Val Asp Ser Cys Gly Glu Tyr Asn Trp Ala Thr Val Gly Gly 
                565                 570                 575     


Arg Arg Arg Ala Val Thr Phe Ser Asn Trp Asn Phe Leu Glu Pro Ala 
            580                 585                 590         


Ser Pro Gly Gly Cys Val Ala Met Ser Thr Gly Lys Ser Val Gly Lys 
        595                 600                 605             


Trp Glu Val Lys Asp Cys Arg Ser Phe Lys Ala Leu Ser Ile Cys Lys 
    610                 615                 620                 


Lys Met Ser Gly Pro Leu Gly Pro Glu Glu Ala Ser Pro Lys Pro Asp 
625                 630                 635                 640 


Asp Pro Cys Pro Glu Gly Trp Gln Ser Phe Pro Ala Ser Leu Ser Cys 
                645                 650                 655     


Tyr Lys Val Phe His Ala Glu Arg Ile Val Arg Lys Arg Asn Trp Glu 
            660                 665                 670         


Glu Ala Glu Arg Phe Cys Gln Ala Leu Gly Ala His Leu Ser Ser Phe 
        675                 680                 685             


Ser His Val Asp Glu Ile Lys Glu Phe Leu His Phe Leu Thr Asp Gln 
    690                 695                 700                 


Phe Ser Gly Gln His Trp Leu Trp Ile Gly Leu Asn Lys Arg Ser Pro 
705                 710                 715                 720 


Asp Leu Gln Gly Ser Trp Gln Trp Ser Asp Arg Thr Pro Val Ser Thr 
                725                 730                 735     


Ile Ile Met Pro Asn Glu Phe Gln Gln Asp Tyr Asp Ile Arg Asp Cys 
            740                 745                 750         


Ala Ala Val Lys Val Phe His Arg Pro Trp Arg Arg Gly Trp His Phe 
        755                 760                 765             


Tyr Asp Asp Arg Glu Phe Ile Tyr Leu Arg Pro Phe Ala Cys Asp Thr 
    770                 775                 780                 


Lys Leu Glu Trp Val Cys Gln Ile Pro Lys Gly Arg Thr Pro Lys Thr 
785                 790                 795                 800 


Pro Asp Trp Tyr Asn Pro Asp Arg Ala Gly Ile His Gly Pro Pro Leu 
                805                 810                 815     


Ile Ile Glu Gly Ser Glu Tyr Trp Phe Val Ala Asp Leu His Leu Asn 
            820                 825                 830         


Tyr Glu Glu Ala Val Leu Tyr Cys Ala Ser Asn His Ser Phe Leu Ala 
        835                 840                 845             


Thr Ile Thr Ser Phe Val Gly Leu Lys Ala Ile Lys Asn Lys Ile Ala 
    850                 855                 860                 


Asn Ile Ser Gly Asp Gly Gln Lys Trp Trp Ile Arg Ile Ser Glu Trp 
865                 870                 875                 880 


Pro Ile Asp Asp His Phe Thr Tyr Ser Arg Tyr Pro Trp His Arg Phe 
                885                 890                 895     


Pro Val Thr Phe Gly Glu Glu Cys Leu Tyr Met Ser Ala Lys Thr Trp 
            900                 905                 910         


Leu Ile Asp Leu Gly Lys Pro Thr Asp Cys Ser Thr Lys Leu Pro Phe 
        915                 920                 925             


Ile Cys Glu Lys Tyr Asn Val Ser Ser Leu Glu Lys Tyr Ser Pro Asp 
    930                 935                 940                 


Ser Ala Ala Lys Val Gln Cys Ser Glu Gln Trp Ile Pro Phe Gln Asn 
945                 950                 955                 960 


Lys Cys Phe Leu Lys Ile Lys Pro Val Ser Leu Thr Phe Ser Gln Ala 
                965                 970                 975     


Ser Asp Thr Cys His Ser Tyr Gly Gly Thr Leu Pro Ser Val Leu Ser 
            980                 985                 990         


Gln Ile Glu Gln Asp Phe Ile Thr  Ser Leu Leu Pro Asp  Met Glu Ala 
        995                 1000                 1005             


Thr Leu  Trp Ile Gly Leu Arg  Trp Thr Ala Tyr Glu  Lys Ile Asn 
    1010                 1015                 1020             


Lys Trp  Thr Asp Asn Arg Glu  Leu Thr Tyr Ser Asn  Phe His Pro 
    1025                 1030                 1035             


Leu Leu  Val Ser Gly Arg Leu  Arg Ile Pro Glu Asn  Phe Phe Glu 
    1040                 1045                 1050             


Glu Glu  Ser Arg Tyr His Cys  Ala Leu Ile Leu Asn  Leu Gln Lys 
    1055                 1060                 1065             


Ser Pro  Phe Thr Gly Thr Trp  Asn Phe Thr Ser Cys  Ser Glu Arg 
    1070                 1075                 1080             


His Phe  Val Ser Leu Cys Gln  Lys Tyr Ser Glu Val  Lys Ser Arg 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asn Ala Ser  Glu Thr Val Lys Tyr  Leu Asn Asn 
    1100                 1105                 1110             


Leu Tyr  Lys Ile Ile Pro Lys  Thr Leu Thr Trp His  Ser Ala Lys 
    1115                 1120                 1125             


Arg Glu  Cys Leu Lys Ser Asn  Met Gln Leu Val Ser  Ile Thr Asp 
    1130                 1135                 1140             


Pro Tyr  Gln Gln Ala Phe Leu  Ser Val Gln Ala Leu  Leu His Asn 
    1145                 1150                 1155             


Ser Ser  Leu Trp Ile Gly Leu  Phe Ser Gln Asp Asp  Glu Leu Asn 
    1160                 1165                 1170             


Phe Gly  Trp Ser Asp Gly Lys  Arg Leu His Phe Ser  Arg Trp Ala 
    1175                 1180                 1185             


Glu Thr  Asn Gly Gln Leu Glu  Asp Cys Val Val Leu  Asp Thr Asp 
    1190                 1195                 1200             


Gly Phe  Trp Lys Thr Val Asp  Cys Asn Asp Asn Gln  Pro Gly Ala 
    1205                 1210                 1215             


Ile Cys  Tyr Tyr Ser Gly Asn  Glu Thr Glu Lys Glu  Val Lys Pro 
    1220                 1225                 1230             


Val Asp  Ser Val Lys Cys Pro  Ser Pro Val Leu Asn  Thr Pro Trp 
    1235                 1240                 1245             


Ile Pro  Phe Gln Asn Cys Cys  Tyr Asn Phe Ile Ile  Thr Lys Asn 
    1250                 1255                 1260             


Arg His  Met Ala Thr Thr Gln  Asp Glu Val His Thr  Lys Cys Gln 
    1265                 1270                 1275             


Lys Leu  Asn Pro Lys Ser His  Ile Leu Ser Ile Arg  Asp Glu Lys 
    1280                 1285                 1290             


Glu Asn  Asn Phe Val Leu Glu  Gln Leu Leu Tyr Phe  Asn Tyr Met 
    1295                 1300                 1305             


Ala Ser  Trp Val Met Leu Gly  Ile Thr Tyr Arg Asn  Lys Ser Leu 
    1310                 1315                 1320             


Met Trp  Phe Asp Lys Thr Pro  Leu Ser Tyr Thr His  Trp Arg Ala 
    1325                 1330                 1335             


Gly Arg  Pro Thr Ile Lys Asn  Glu Lys Phe Leu Ala  Gly Leu Ser 
    1340                 1345                 1350             


Thr Asp  Gly Phe Trp Asp Ile  Gln Thr Phe Lys Val  Ile Glu Glu 
    1355                 1360                 1365             


Ala Val  Tyr Phe His Gln His  Ser Ile Leu Ala Cys  Lys Ile Glu 
    1370                 1375                 1380             


Met Val  Asp Tyr Lys Glu Glu  Tyr Asn Thr Thr Leu  Pro Gln Phe 
    1385                 1390                 1395             


Met Pro  Tyr Glu Asp Gly Ile  Tyr Ser Val Ile Gln  Lys Lys Val 
    1400                 1405                 1410             


Thr Trp  Tyr Glu Ala Leu Asn  Met Cys Ser Gln Ser  Gly Gly His 
    1415                 1420                 1425             


Leu Ala  Ser Val His Asn Gln  Asn Gly Gln Leu Phe  Leu Glu Asp 
    1430                 1435                 1440             


Ile Val  Lys Arg Asp Gly Phe  Pro Leu Trp Val Gly  Leu Ser Ser 
    1445                 1450                 1455             


His Asp  Gly Ser Glu Ser Ser  Phe Glu Trp Ser Asp  Gly Ser Thr 
    1460                 1465                 1470             


Phe Asp  Tyr Ile Pro Trp Lys  Gly Gln Thr Ser Pro  Gly Asn Cys 
    1475                 1480                 1485             


Val Leu  Leu Asp Pro Lys Gly  Thr Trp Lys His Glu  Lys Cys Asn 
    1490                 1495                 1500             


Ser Val  Lys Asp Gly Ala Ile  Cys Tyr Lys Pro Thr  Lys Ser Lys 
    1505                 1510                 1515             


Lys Leu  Ser Arg Leu Thr Tyr  Ser Ser Arg Cys Pro  Ala Ala Lys 
    1520                 1525                 1530             


Glu Asn  Gly Ser Arg Trp Ile  Gln Tyr Lys Gly His  Cys Tyr Lys 
    1535                 1540                 1545             


Ser Asp  Gln Ala Leu His Ser  Phe Ser Glu Ala Lys  Lys Leu Cys 
    1550                 1555                 1560             


Ser Lys  His Asp His Ser Ala  Thr Ile Val Ser Ile  Lys Asp Glu 
    1565                 1570                 1575             


Asp Glu  Asn Lys Phe Val Ser  Arg Leu Met Arg Glu  Asn Asn Asn 
    1580                 1585                 1590             


Ile Thr  Met Arg Val Trp Leu  Gly Leu Ser Gln His  Ser Val Asp 
    1595                 1600                 1605             


Gln Ser  Trp Ser Trp Leu Asp  Gly Ser Glu Val Thr  Phe Val Lys 
    1610                 1615                 1620             


Trp Glu  Asn Lys Ser Lys Ser  Gly Val Gly Arg Cys  Ser Met Leu 
    1625                 1630                 1635             


Ile Ala  Ser Asn Glu Thr Trp  Lys Lys Val Glu Cys  Glu His Gly 
    1640                 1645                 1650             


Phe Gly  Arg Val Val Cys Lys  Val Pro Leu Gly Pro  Asp Tyr Thr 
    1655                 1660                 1665             


Ala Ile  Ala Ile Ile Val Ala  Thr Leu Ser Ile Leu  Val Leu Met 
    1670                 1675                 1680             


Gly Gly  Leu Ile Trp Phe Leu  Phe Gln Arg His Arg  Leu His Leu 
    1685                 1690                 1695             


Ala Gly  Phe Ser Ser Val Arg  Tyr Ala Gln Gly Val  Asn Glu Asp 
    1700                 1705                 1710             


Glu Ile  Met Leu Pro Ser Phe  His Asp 
    1715                 1720         


<210>  3
<211>  1616
<212>  DNA
<213>  Homo sapiens

<400>  3
gccaaggctg gggcagggga gtcagcagag gcctcgctcg ggcgcccagt ggtcctgccg       60

cctggtctca cctcgctatg gttcgtctgc ctctgcagtg cgtcctctgg ggctgcttgc      120

tgaccgctgt ccatccagaa ccacccactg catgcagaga aaaacagtac ctaataaaca      180

gtcagtgctg ttctttgtgc cagccaggac agaaactggt gagtgactgc acagagttca      240

ctgaaacgga atgccttcct tgcggtgaaa gcgaattcct agacacctgg aacagagaga      300

cacactgcca ccagcacaaa tactgcgacc ccaacctagg gcttcgggtc cagcagaagg      360

gcacctcaga aacagacacc atctgcacct gtgaagaagg ctggcactgt acgagtgagg      420

cctgtgagag ctgtgtcctg caccgctcat gctcgcccgg ctttggggtc aagcagattg      480

ctacaggggt ttctgatacc atctgcgagc cctgcccagt cggcttcttc tccaatgtgt      540

catctgcttt cgaaaaatgt cacccttgga caagctgtga gaccaaagac ctggttgtgc      600

aacaggcagg cacaaacaag actgatgttg tctgtggtcc ccaggatcgg ctgagagccc      660

tggtggtgat ccccatcatc ttcgggatcc tgtttgccat cctcttggtg ctggtcttta      720

tcaaaaaggt ggccaagaag ccaaccaata aggcccccca ccccaagcag gaaccccagg      780

agatcaattt tcccgacgat cttcctggct ccaacactgc tgctccagtg caggagactt      840

tacatggatg ccaaccggtc acccaggagg atggcaaaga gagtcgcatc tcagtgcagg      900

agagacagtg aggctgcacc cacccaggag tgtggccacg tgggcaaaca ggcagttggc      960

cagagagcct ggtgctgctg ctgctgtggc gtgagggtga ggggctggca ctgactgggc     1020

atagctcccc gcttctgcct gcacccctgc agtttgagac aggagacctg gcactggatg     1080

cagaaacagt tcaccttgaa gaacctctca cttcaccctg gagcccatcc agtctcccaa     1140

cttgtattaa agacagaggc agaagtttgg tggtggtggt gttggggtat ggtttagtaa     1200

tatccaccag accttccgat ccagcagttt ggtgcccaga gaggcatcat ggtggcttcc     1260

ctgcgcccag gaagccatat acacagatgc ccattgcagc attgtttgtg atagtgaaca     1320

actggaagct gcttaactgt ccatcagcag gagactggct aaataaaatt agaatatatt     1380

tatacaacag aatctcaaaa acactgttga gtaaggaaaa aaaggcatgc tgctgaatga     1440

tgggtatgga actttttaaa aaagtacatg cttttatgta tgtatattgc ctatggatat     1500

atgtataaat acaatatgca tcatatattg atataacaag ggttctggaa gggtacacag     1560

aaaacccaca gctcgaagag tggtgacgtc tggggtgggg aagaagggtc tggggg         1616


<210>  4
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T-helper epitope

<400>  5

Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      


Ala Ser His Leu Glu 
            20      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T-helper cell epitope

<400>  6

Gly Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser 
1               5                   10                  15      


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  7

Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  8

Leu Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val 
1               5                   10                  15  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  9

Thr Ala Ala Gln Ile Thr Ala Gly Ile Ala Leu His Gln Ser Asn Leu 
1               5                   10                  15      


Asn 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  10

Ile Gly Thr Asp Asn Val His Tyr Lys Ile Met Thr Arg Pro Ser His 
1               5                   10                  15      


Gln 
    


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  11

Tyr Lys Ile Met Thr Arg Pro Ser His Gln Tyr Leu Val Ile Lys Leu 
1               5                   10                  15      


Ile 
    


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  12

Ser His Gln Tyr Leu Val Ile Lys Leu Ile Pro Asn Ala Ser Leu Ile 
1               5                   10                  15      


Glu 
    


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  13

Lys Leu Ile Pro Asn Ala Ser Leu Ile Glu Asn Cys Thr Lys Ala Glu 
1               5                   10                  15      


Leu 
    


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  14

Leu Ile Glu Asn Cys Thr Lys Ala Glu Leu Gly Glu Tyr Glu Lys Leu 
1               5                   10                  15      


Leu 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  15

Ala Glu Leu Gly Glu Tyr Glu Lys Leu Leu Asn Ser Val Leu Glu Pro 
1               5                   10                  15      


Ile 
    


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  16

Lys Leu Leu Asn Ser Val Leu Glu Pro Ile Asn Gln Ala Leu Thr Leu 
1               5                   10                  15      


Met 
    


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  17

Glu Pro Ile Asn Gln Ala Leu Thr Leu Met Thr Lys Asn Val Lys Pro 
1               5                   10                  15      


Leu 
    


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  18

Thr Leu Met Thr Lys Asn Val Lys Pro Leu Gln Ser Leu Gly Ser Gly 
1               5                   10                  15      


Arg 
    


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  19

Lys Pro Leu Gln Ser Leu Gly Ser Gly Arg Arg Gln Arg Arg Phe Ala 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  20

Ser Gly Arg Arg Gln Arg Arg Phe Ala Gly Val Val Leu Ala Gly Val 
1               5                   10                  15      


Ala 
    


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  21

Phe Ala Gly Val Val Leu Ala Gly Val Ala Leu Gly Val Ala Thr Ala 
1               5                   10                  15      


Ala 
    


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  22

Gly Val Ala Leu Gly Val Ala Thr Ala Ala Gln Ile Thr Ala Gly Ile 
1               5                   10                  15      


Ala 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  23

Gly Ile Ala Leu His Gln Ser Asn Leu Asn Ala Gln Ala Ile Gln Ser 
1               5                   10                  15      


Leu 
    


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  24

Asn Leu Asn Ala Gln Ala Ile Gln Ser Leu Arg Thr Ser Leu Glu Gln 
1               5                   10                  15      


Ser 
    


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  25

Gln Ser Leu Arg Thr Ser Leu Glu Gln Ser Asn Lys Ala Ile Glu Glu 
1               5                   10                  15      


Ile 
    


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  26

Glu Gln Ser Asn Lys Ala Ile Glu Glu Ile Arg Glu Ala Thr Gln Glu 
1               5                   10                  15      


Thr 
    


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  27

Ser Ser Lys Thr Gln Thr His Thr Gln Gln Asp Arg Pro Pro Gln Pro 
1               5                   10                  15      


Ser 
    


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  28

Gln Pro Ser Thr Glu Leu Glu Glu Thr Arg Thr Ser Arg Ala Arg His 
1               5                   10                  15      


Ser 
    


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  29

Arg His Ser Thr Thr Ser Ala Gln Arg Ser Thr His Tyr Asp Pro Arg 
1               5                   10                  15      


Thr 
    


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  30

Pro Arg Thr Ser Asp Arg Pro Val Ser Tyr Thr Met Asn Arg Thr Arg 
1               5                   10                  15      


Ser 
    


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  31

Thr Arg Ser Arg Lys Gln Thr Ser His Arg Leu Lys Asn Ile Pro Val 
1               5                   10                  15      


His 
    


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  32

Thr Glu Leu Leu Ser Ile Phe Gly Pro Ser Leu Arg Asp Pro Ile Ser 
1               5                   10                  15      


Ala 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  33

Pro Arg Tyr Ile Ala Thr Asn Gly Tyr Leu Ile Ser Asn Phe Asp Glu 
1               5                   10                  15      


Ser 
    


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  34

Cys Ile Arg Gly Asp Thr Ser Ser Cys Ala Arg Thr Leu Val Ser Gly 
1               5                   10                  15      


Thr 
    


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  35

Asp Glu Ser Ser Cys Val Phe Val Ser Glu Ser Ala Ile Cys Ser Gln 
1               5                   10                  15      


Asn 
    


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  36

Thr Ser Thr Ile Ile Asn Gln Ser Pro Asp Lys Leu Leu Thr Phe Ile 
1               5                   10                  15      


Ala 
    


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  37

Ser Pro Asp Lys Leu Leu Thr Phe Ile Ala Ser Asp Thr Cys Pro Leu 
1               5                   10                  15      


Val 
    


<210>  38
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  38

Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg 
1               5                   10                  15      


Ala Pro Gly Ser Thr Ala Pro Pro 
            20                  


<210>  39
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  39

Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
1               5                   10                  15      


Ser Ser Leu 
            


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  40

Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
1               5                   10                  15      


Ser Leu 
        


<210>  41
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  41

Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
1               5                   10                  15      


Ala Pro Gly Ser Thr Ala Pro Pro Lys Lys Gly 
            20                  25          


<210>  42
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  42

Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg 
1               5                   10                  15      


Pro Ala Pro Gly Ser Thr Ala Pro Pro Lys 
            20                  25      


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  43

Gly Val Ala Glu 
1               


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  44

Thr Ala Ser Gly Val Ala Glu Thr Thr Asn 
1               5                   10  


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-helper cell epitope

<400>  45

Thr Ala Lys Ser Lys Lys Phe Pro Ser Tyr Thr Ala Thr Tyr Gln Phe 
1               5                   10                  15      


<210>  46
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mCD40 antigen-P30

<400>  46
ctagggcagt gtgttacgtg cagtgacaaa cagtacctcc acgatggcca gtgctgtgat       60

ttgtgccagc caggaagccg actgacaagc cactgcacag ctcttgagaa gacccaatgc      120

cacccatgtg actcaggcga attctcagcc cagtggaaca gggagattcg ctgtcaccag      180

cacagacact gtgaacccaa tcaagggctt cgggttaaga aggagggcac cgcagaatca      240

gacactgtct gtacctgtaa ggaaggacaa cactgcacca gcaaggattg cgaggcatgt      300

gctcagcaca cgccctgtat ccctggcttt ggagttatgg agatggccac tgagaccact      360

gataccgtct gtcatccctg cccagtcggc ttcttctcca atcagtcatc acttttcgaa      420

aagtgttatc cctggacaag ctgtgaggat aagaacttgg aggtcctaca gaaaggaacg      480

agtcagacta atgtcatctg tggtttaaag tcccggatgc gattcaacaa cttcaccgtc      540

agcttctggc tgcgcgtgcc caaggtcagc gccagccacc tggag                      585


<210>  47
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mCD40 antigen-P30

<400>  47

Leu Gly Gln Cys Val Thr Cys Ser Asp Lys Gln Tyr Leu His Asp Gly 
1               5                   10                  15      


Gln Cys Cys Asp Leu Cys Gln Pro Gly Ser Arg Leu Thr Ser His Cys 
            20                  25                  30          


Thr Ala Leu Glu Lys Thr Gln Cys His Pro Cys Asp Ser Gly Glu Phe 
        35                  40                  45              


Ser Ala Gln Trp Asn Arg Glu Ile Arg Cys His Gln His Arg His Cys 
    50                  55                  60                  


Glu Pro Asn Gln Gly Leu Arg Val Lys Lys Glu Gly Thr Ala Glu Ser 
65                  70                  75                  80  


Asp Thr Val Cys Thr Cys Lys Glu Gly Gln His Cys Thr Ser Lys Asp 
                85                  90                  95      


Cys Glu Ala Cys Ala Gln His Thr Pro Cys Ile Pro Gly Phe Gly Val 
            100                 105                 110         


Met Glu Met Ala Thr Glu Thr Thr Asp Thr Val Cys His Pro Cys Pro 
        115                 120                 125             


Val Gly Phe Phe Ser Asn Gln Ser Ser Leu Phe Glu Lys Cys Tyr Pro 
    130                 135                 140                 


Trp Thr Ser Cys Glu Asp Lys Asn Leu Glu Val Leu Gln Lys Gly Thr 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ile Cys Gly Leu Lys Ser Arg Met Arg Phe Asn 
                165                 170                 175     


Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser 
            180                 185                 190         


His Leu Glu 
        195 


<210>  48
<211>  727
<212>  DNA
<213>  Homo sapiens

<400>  48
atgcacgagg aagaaatata cacctctctt cagtgggata gcccagcacc agacacttac       60

cagaaatgtc tgtcttccaa caaatgttca ggagcatgct gtcttgtgat ggtgatttca      120

tgtgttttct gcatgggatt attaacagca tccattttct tgggcgtcaa gttgttgcag      180

gtgtccacca ttgcgatgca gcagcaagaa aaactcatcc aacaagagag ggcactgcta      240

aactttacag aatggaagag aagctgtgcc cttcagatga aatattgcca agccttcatg      300

caaaactcat taagttcagc ccataacagc agtccttgtc caaacaattg gattcagaac      360

agagaaagtt gttactatgt ctctgaaatt tggagcattt ggcacaccag tcaagagaat      420

tgtttaaagg aaggttccac gctgctacaa atagagagca aagaagaaat ggattttatc      480

actggcagct tgaggaagat taaaggaagc tatgattact gggtggggtt gtctcaggat      540

ggacacagcg gacgctggct ttggcaagat ggctcctctc cttctcctgg cctgttgcca      600

gcagagagat cccagtcagc taaccaagtc tgtggatacg tgaaaagcaa ttcccttctt      660

tcgtctaact gcagcacgtg gaagtatttt atctgtgaga agtatgcgtt gagatcctct      720

gtctgaa                                                                727


<210>  49
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  49

Met His Glu Glu Glu Ile Tyr Thr Ser Leu Gln Trp Asp Ser Pro Ala 
1               5                   10                  15      


Pro Asp Thr Tyr Gln Lys Cys Leu Ser Ser Asn Lys Cys Ser Gly Ala 
            20                  25                  30          


Cys Cys Leu Val Met Val Ile Ser Cys Val Phe Cys Met Gly Leu Leu 
        35                  40                  45              


Thr Ala Ser Ile Phe Leu Gly Val Lys Leu Leu Gln Val Ser Thr Ile 
    50                  55                  60                  


Ala Met Gln Gln Gln Glu Lys Leu Ile Gln Gln Glu Arg Ala Leu Leu 
65                  70                  75                  80  


Asn Phe Thr Glu Trp Lys Arg Ser Cys Ala Leu Gln Met Lys Tyr Cys 
                85                  90                  95      


Gln Ala Phe Met Gln Asn Ser Leu Ser Ser Ala His Asn Ser Ser Pro 
            100                 105                 110         


Cys Pro Asn Asn Trp Ile Gln Asn Arg Glu Ser Cys Tyr Tyr Val Ser 
        115                 120                 125             


Glu Ile Trp Ser Ile Trp His Thr Ser Gln Glu Asn Cys Leu Lys Glu 
    130                 135                 140                 


Gly Ser Thr Leu Leu Gln Ile Glu Ser Lys Glu Glu Met Asp Phe Ile 
145                 150                 155                 160 


Thr Gly Ser Leu Arg Lys Ile Lys Gly Ser Tyr Asp Tyr Trp Val Gly 
                165                 170                 175     


Leu Ser Gln Asp Gly His Ser Gly Arg Trp Leu Trp Gln Asp Gly Ser 
            180                 185                 190         


Ser Pro Ser Pro Gly Leu Leu Pro Ala Glu Arg Ser Gln Ser Ala Asn 
        195                 200                 205             


Gln Val Cys Gly Tyr Val Lys Ser Asn Ser Leu Leu Ser Ser Asn Cys 
    210                 215                 220                 


Ser Thr Trp Lys Tyr Phe Ile Cys Glu Lys Tyr Ala Leu Arg Ser Ser 
225                 230                 235                 240 


Val 
    


<210>  50
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  50
atgagtgact ccaaggaacc aagactgcag cagctgggcc tcctggagga ggaacagctg       60

agaggccttg gattccgaca gactcgagga tacaagagct tagcagggtg tcttggccat      120

ggtcccctgg tgctgcaact cctctccttc acgctcttgg ctgggctcct tgtccaagtg      180

tccaaggtcc ccagctccat aagtcaggaa caatccaggc aagacgcgat ctaccagaac      240

ctgacccagc ttaaagctgc agtgggtgag ctctcagaga aatccaagct gcaggagatc      300

taccaggagc tgacccagct gaaggctgca gtgggtgagc ttccagagaa atctaagctg      360

caggagatct accaggagct gacccggctg aaggctgcag tgggtgagct tccagagaaa      420

tctaagctgc aggagatcta ccaggagctg acctggctga aggctgcagt gggtgagctt      480

ccagagaaat ctaagatgca ggagatctac caggagctga ctcggctgaa ggctgcagtg      540

ggtgagcttc cagagaaatc taagcagcag gagatctacc aggagctgac ccggctgaag      600

gctgcagtgg gtgagcttcc agagaaatct aagcagcagg agatctacca ggagctgacc      660

cggctgaagg ctgcagtggg tgagcttcca gagaaatcta agcagcagga gatctaccag      720

gagctgaccc agctgaaggc tgcagtggaa cgcctgtgcc acccctgtcc ctgggaatgg      780

acattcttcc aaggaaactg ttacttcatg tctaactccc agcggaactg gcacgactcc      840

atcaccgcct gcaaagaagt gggggcccag ctcgtcgtaa tcaaaagtgc tgaggagcag      900

aacttcctac agctgcagtc ttccagaagt aaccgcttca cctggatggg actttcagat      960

ctaaatcagg aaggcacgtg gcaatgggtg gacggctcac ctctgttgcc cagcttcaag     1020

cagtattgga acagaggaga gcccaacaac gttggggagg aagactgcgc ggaatttagt     1080

ggcaatggct ggaacgacga caaatgtaat cttgccaaat tctggatctg caaaaagtcc     1140

gcagcctcct gctccaggga tgaagaacag tttctttctc cagcccctgc caccccaaac     1200

ccccctcctg cgtagcagaa cttcaccccc ttttaa                               1236


<210>  51
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Thr Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Thr Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
                85                  90                  95      


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly 
            100                 105                 110         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
        115                 120                 125             


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
    130                 135                 140                 


Glu Ile Tyr Gln Glu Leu Thr Trp Leu Lys Ala Ala Val Gly Glu Leu 
145                 150                 155                 160 


Pro Glu Lys Ser Lys Met Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu 
                165                 170                 175     


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile 
            180                 185                 190         


Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        195                 200                 205             


Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    210                 215                 220                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln 
225                 230                 235                 240 


Glu Leu Thr Gln Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys 
                245                 250                 255     


Pro Trp Glu Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            260                 265                 270         


Ser Gln Arg Asn Trp His Asp Ser Ile Thr Ala Cys Lys Glu Val Gly 
        275                 280                 285             


Ala Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln Asn Phe Leu Gln 
    290                 295                 300                 


Leu Gln Ser Ser Arg Ser Asn Arg Phe Thr Trp Met Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Leu 
                325                 330                 335     


Pro Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro Asn Asn Val Gly 
            340                 345                 350         


Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys 
        355                 360                 365             


Cys Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser Ala Ala Ser Cys 
    370                 375                 380                 


Ser Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro Ala Thr Pro Asn 
385                 390                 395                 400 


Pro Pro Pro Ala 
                


<210>  52
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide designated CD40-Nterm-FW

<400>  52
cgtggcggcc gcctagggca gtgtgttacg tgc                                    33


<210>  53
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide designated CD40-P30-Rev

<400>  53
gggcacgcgc agccagaagc tgacggtgaa gttgttgaat cgcatccggg actttaaacc       60


<210>  54
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide designated P30-Cterm template

<400>  54
agcttctggc tgcgcgtgcc caaggtcagc gccagccacc tggag                       45


<210>  55
<211>  31
<212>  DNA
<213>  artificial

<220>
<223>  Oligonucleotide designated P30-Cterm-Rev

<400>  55
cagtccgcgg ctccaggtgg ctggcgctga c                                      31


<210>  56
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Sequencing oligonucleotide

<400>  56
gcgaatgaat tgggacct                                                     18


<210>  57
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  Sequencing oligonucleotide

<400>  57
cttctgagat gagtttttgt tcg                                               23


