                         SEQUENCE LISTING

<110>  Spiber Technologies AB
       Immunovia AB
 
<120>  SPIDER SILK FUSION PROTEIN STRUCTURES INCORPORATING 
       IMMUNOGLOBULIN FRAGMENTS AS AFFINITY LIGANDS

<130>  PC-21061940

<150>  EP 12166392
<151>  2012-05-02

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  149
<212>  PRT
<213>  Euprosthenops australis

<400>  1

Gly Ser Gly Asn Ser Gly Ile Gln Gly Gln Gly Gly Tyr Gly Gly Leu 
1               5                   10                  15      


Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln 
        35                  40                  45              


Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr 
65                  70                  75                  80  


Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln 
            100                 105                 110         


Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gln Gly Gln Gly 
    130                 135                 140                 


Gly Tyr Gly Gln Ser 
145                 


<210>  2
<211>  265
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  DOMAIN
<222>  (1)..(167)
<223>  REP fragment

<220>
<221>  DOMAIN
<222>  (168)..(265)
<223>  CT fragment

<400>  2

Gly Ser Gly Asn Ser Gly Ile Gln Gly Gln Gly Gly Tyr Gly Gly Leu 
1               5                   10                  15      


Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln 
        35                  40                  45              


Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr 
65                  70                  75                  80  


Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln 
            100                 105                 110         


Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gln Gly Gln Gly 
    130                 135                 140                 


Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala 
145                 150                 155                 160 


Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala Val 
                165                 170                 175     


Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln Val 
            180                 185                 190         


Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser Val 
        195                 200                 205             


Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln Ala 
    210                 215                 220                 


Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser Ser 
225                 230                 235                 240 


Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val Val 
                245                 250                 255     


Ala Asn Ala Met Ala Gln Val Met Gly 
            260                 265 


<210>  3
<211>  296
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  DOMAIN
<222>  (1)..(137)
<223>  NT fragment

<220>
<221>  DOMAIN
<222>  (138)..(296)
<223>  REP fragment

<400>  3

Gly Ser Gly Asn Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala 
1               5                   10                  15      


Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly 
            20                  25                  30          


Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met 
        35                  40                  45              


Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn 
    50                  55                  60                  


Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile 
65                  70                  75                  80  


Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser 
                85                  90                  95      


Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val 
            100                 105                 110         


Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala 
        115                 120                 125             


Gln Ala Gly Met Asn Asp Val Ser Ala Ser Ala Ser Ala Gly Ala Ser 
    130                 135                 140                 


Ala Ala Ala Ser Ala Gly Ala Ala Ser Gly Gln Gly Gly Tyr Gly Gly 
145                 150                 155                 160 


Leu Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly 
            180                 185                 190         


Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly 
    210                 215                 220                 


Tyr Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly 
                245                 250                 255     


Arg Gln Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gly Gln 
        275                 280                 285             


Gly Gln Gly Gly Tyr Gly Gln Ser 
    290                 295     


<210>  4
<211>  340
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  DOMAIN
<222>  (1)..(137)
<223>  NT fragment

<220>
<221>  DOMAIN
<222>  (138)..(340)
<223>  REP fragment

<400>  4

Gly Ser Gly Asn Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala 
1               5                   10                  15      


Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly 
            20                  25                  30          


Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met 
        35                  40                  45              


Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn 
    50                  55                  60                  


Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile 
65                  70                  75                  80  


Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser 
                85                  90                  95      


Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val 
            100                 105                 110         


Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala 
        115                 120                 125             


Gln Ala Gly Met Asn Asp Val Ser Ala Ser Ala Ser Ala Gly Ala Ser 
    130                 135                 140                 


Ala Ala Ala Ser Ala Gly Ala Pro Gly Tyr Ser Pro Ala Pro Ser Tyr 
145                 150                 155                 160 


Ser Ser Gly Gly Tyr Ala Ser Ser Ala Ala Ser Ala Ala Ala Ala Ala 
                165                 170                 175     


Gly Gln Gly Gly Pro Gly Gly Tyr Gly Pro Ala Pro Asn Gln Gly Ala 
            180                 185                 190         


Ser Ser Ala Ala Ala Ala Ala Ala Gly Ser Gly Gln Gly Pro Ser Gly 
        195                 200                 205             


Pro Tyr Gly Thr Ser Tyr Gln Ile Ser Thr Gln Tyr Thr Gln Thr Thr 
    210                 215                 220                 


Thr Ser Gln Gly Gln Gly Tyr Gly Ser Ser Ser Ala Gly Ala Ala Ala 
225                 230                 235                 240 


Ala Gly Ala Ala Gly Ala Gly Gln Gly Gly Tyr Gly Gly Gln Gly Gln 
                245                 250                 255     


Gly Gly Tyr Gly Gln Gly Ala Gly Gly Ala Ala Ala Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Gly 
        275                 280                 285             


Gly Tyr Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Gln Gly Gln Gly 
    290                 295                 300                 


Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Pro 
                325                 330                 335     


Gly Ser Gly Gly 
            340 


<210>  5
<211>  424
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  DOMAIN
<222>  (1)..(136)
<223>  NT fragment

<220>
<221>  DOMAIN
<222>  (137)..(313)
<223>  REP fragment

<220>
<221>  DOMAIN
<222>  (314)..(411)
<223>  CT fragment

<220>
<221>  DOMAIN
<222>  (412)..(424)
<223>  His tag

<400>  5

Met Lys Ala Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu 
1               5                   10                  15      


Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe 
            20                  25                  30          


Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met Val 
        35                  40                  45              


Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Lys 
    50                  55                  60                  


Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala 
65                  70                  75                  80  


Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile 
                85                  90                  95      


Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn 
            100                 105                 110         


Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln 
        115                 120                 125             


Ala Gly Met Asn Asp Val Ser Ala Ser Ala Ser Ala Gly Ala Ser Ala 
    130                 135                 140                 


Ala Ala Ser Ala Gly Ala Ala Ser Gly Gln Gly Gly Tyr Gly Gly Leu 
145                 150                 155                 160 


Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln 
            180                 185                 190         


Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr 
    210                 215                 220                 


Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg 
                245                 250                 255     


Gln Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gly Gln Gly 
        275                 280                 285             


Gln Gly Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser 
    290                 295                 300                 


Ala Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser 
305                 310                 315                 320 


Ala Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly 
                325                 330                 335     


Gln Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser 
            340                 345                 350         


Ser Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val 
        355                 360                 365             


Gln Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser 
    370                 375                 380                 


Ser Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn 
385                 390                 395                 400 


Val Val Ala Asn Ala Met Ala Gln Val Met Gly Lys Leu Ala Ala Ala 
                405                 410                 415     


Leu Glu His His His His His His 
            420                 


<210>  6
<211>  137
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  deletion (deltaHis)

<400>  6

Gly Ser Gly Asn Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala 
1               5                   10                  15      


Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly 
            20                  25                  30          


Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met 
        35                  40                  45              


Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn 
    50                  55                  60                  


Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile 
65                  70                  75                  80  


Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser 
                85                  90                  95      


Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val 
            100                 105                 110         


Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala 
        115                 120                 125             


Gln Ala Gly Met Asn Asp Val Ser Ala 
    130                 135         


<210>  7
<211>  98
<212>  PRT
<213>  Euprosthenops australis

<400>  7

Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro Asn 
            20                  25                  30          


Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly Ala 
        35                  40                  45              


Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr Ala 
    50                  55                  60                  


Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser 
65                  70                  75                  80  


Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln Val 
                85                  90                  95      


Met Gly 
        


<210>  8
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from spidroin NT fragments


<220>
<221>  VARIANT
<222>  (20)..(20)
<223>  Leu

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  Asn

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  Gln

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  Ser

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  Lys

<220>
<221>  VARIANT
<222>  (56)..(56)
<223>  Arg

<220>
<221>  VARIANT
<222>  (84)..(84)
<223>  Leu

<220>
<221>  VARIANT
<222>  (114)..(114)
<223>  Ser

<220>
<221>  VARIANT
<222>  (121)..(121)
<223>  Asn

<220>
<221>  VARIANT
<222>  (123)..(123)
<223>  Leu

<220>
<221>  VARIANT
<222>  (124)..(124)
<223>  Ser

<400>  8

Gln Ala Asn Thr Pro Trp Ser Ser Pro Asn Leu Ala Asp Ala Phe Ile 
1               5                   10                  15      


Asn Ser Phe Met Ser Ala Ala Ser Ser Ser Gly Ala Phe Ser Ala Asp 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Thr Ile Gly Asp Thr Leu Met Ser Ala Met 
        35                  40                  45              


Asp Asn Met Gly Arg Ser Gly Lys Ser Thr Lys Ser Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ala Glu 
65                  70                  75                  80  


Ser Gly Gly Gly Ser Val Gly Val Lys Thr Asn Ala Ile Ser Asp Ala 
                85                  90                  95      


Leu Ser Ser Ala Phe Tyr Gln Thr Thr Gly Ser Val Asn Pro Gln Phe 
            100                 105                 110         


Val Asn Glu Ile Arg Ser Leu Ile Gly Met Phe Ala Gln Ala Ser Ala 
        115                 120                 125             


Asn Glu Val 
    130     


<210>  9
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from known MaSp1 and MaSp2 proteins


<220>
<221>  MISC_FEATURE
<222>  (1)..(71)
<223>  Sequence length present in known species variants

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Glu

<400>  9

Ser Arg Leu Ser Ser Pro Gln Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Asn Ser Ala Ala Leu Ser Asn 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Ser Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Val His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln Ile Val Gly Gln Ser Val Ala Gln Ala 
                85                  90                  95      


Leu Gly Glu Phe 
            100 


<210>  10
<211>  1110
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  REPEAT
<222>  (7)..(19)

<220>
<221>  REPEAT
<222>  (20)..(42)

<220>
<221>  REPEAT
<222>  (43)..(56)

<220>
<221>  REPEAT
<222>  (57)..(70)

<220>
<221>  REPEAT
<222>  (71)..(83)

<220>
<221>  REPEAT
<222>  (84)..(106)

<220>
<221>  REPEAT
<222>  (107)..(120)

<220>
<221>  REPEAT
<222>  (121)..(134)

<220>
<221>  REPEAT
<222>  (135)..(147)

<220>
<221>  REPEAT
<222>  (148)..(170)

<220>
<221>  REPEAT
<222>  (171)..(183)

<220>
<221>  REPEAT
<222>  (184)..(197)

<220>
<221>  REPEAT
<222>  (198)..(211)

<220>
<221>  REPEAT
<222>  (212)..(234)

<220>
<221>  REPEAT
<222>  (235)..(248)

<220>
<221>  REPEAT
<222>  (249)..(265)

<220>
<221>  REPEAT
<222>  (266)..(279)

<220>
<221>  REPEAT
<222>  (280)..(293)

<220>
<221>  REPEAT
<222>  (294)..(306)

<220>
<221>  REPEAT
<222>  (307)..(329)

<220>
<221>  REPEAT
<222>  (330)..(342)

<220>
<221>  REPEAT
<222>  (343)..(356)

<220>
<221>  REPEAT
<222>  (357)..(370)

<220>
<221>  REPEAT
<222>  (371)..(393)

<220>
<221>  REPEAT
<222>  (394)..(406)

<220>
<221>  REPEAT
<222>  (407)..(420)

<220>
<221>  REPEAT
<222>  (421)..(434)

<220>
<221>  REPEAT
<222>  (435)..(457)

<220>
<221>  REPEAT
<222>  (458)..(470)

<220>
<221>  REPEAT
<222>  (471)..(488)

<220>
<221>  REPEAT
<222>  (489)..(502)

<220>
<221>  REPEAT
<222>  (503)..(516)

<220>
<221>  REPEAT
<222>  (517)..(529)

<220>
<221>  REPEAT
<222>  (530)..(552)

<220>
<221>  REPEAT
<222>  (553)..(566)

<220>
<221>  REPEAT
<222>  (567)..(580)

<220>
<221>  REPEAT
<222>  (581)..(594)

<220>
<221>  REPEAT
<222>  (595)..(617)

<220>
<221>  REPEAT
<222>  (618)..(630)

<220>
<221>  REPEAT
<222>  (631)..(647)

<220>
<221>  REPEAT
<222>  (648)..(661)

<220>
<221>  REPEAT
<222>  (662)..(675)

<220>
<221>  REPEAT
<222>  (676)..(688)

<220>
<221>  REPEAT
<222>  (689)..(711)

<220>
<221>  REPEAT
<222>  (712)..(725)

<220>
<221>  REPEAT
<222>  (726)..(739)

<220>
<221>  REPEAT
<222>  (740)..(752)

<220>
<221>  REPEAT
<222>  (753)..(775)

<220>
<221>  REPEAT
<222>  (776)..(789)

<220>
<221>  REPEAT
<222>  (790)..(803)

<220>
<221>  REPEAT
<222>  (804)..(816)

<220>
<221>  REPEAT
<222>  (817)..(839)

<220>
<221>  REPEAT
<222>  (840)..(853)

<220>
<221>  REPEAT
<222>  (854)..(867)

<220>
<221>  REPEAT
<222>  (868)..(880)

<220>
<221>  REPEAT
<222>  (881)..(903)

<220>
<221>  REPEAT
<222>  (904)..(917)

<220>
<221>  REPEAT
<222>  (918)..(931)

<220>
<221>  REPEAT
<222>  (932)..(945)

<220>
<221>  REPEAT
<222>  (946)..(968)

<220>
<221>  REPEAT
<222>  (969)..(981)

<220>
<221>  REPEAT
<222>  (982)..(998)

<220>
<221>  REPEAT
<222>  (999)..(1013)

<220>
<221>  REPEAT
<222>  (1014)..(1027)

<220>
<221>  REPEAT
<222>  (1028)..(1042)

<220>
<221>  REPEAT
<222>  (1043)..(1059)

<220>
<221>  REPEAT
<222>  (1060)..(1073)

<220>
<221>  REPEAT
<222>  (1074)..(1092)

<400>  10

Gln Gly Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln 
            20                  25                  30          


Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly 
    50                  55                  60                  


Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ser Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Gln Gly Gln 
                85                  90                  95      


Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala 
            100                 105                 110         


Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gln Gly Arg Tyr Gly 
        115                 120                 125             


Gln Gly Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln 
145                 150                 155                 160 


Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala 
                165                 170                 175     


Ser Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln 
            180                 185                 190         


Gly Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln 
    210                 215                 220                 


Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala 
225                 230                 235                 240 


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly 
                245                 250                 255     


Arg Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gln Gly Gly Tyr Gly Gln 
        275                 280                 285             


Gly Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln Gly 
305                 310                 315                 320 


Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
                325                 330                 335     


Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly 
            340                 345                 350         


Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Ala Ala 
        355                 360                 365             


Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly 
    370                 375                 380                 


Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly 
                405                 410                 415     


Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly 
        435                 440                 445             


Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Arg 
465                 470                 475                 480 


Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala 
                485                 490                 495     


Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly 
            500                 505                 510         


Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        515                 520                 525             


Ser Gly Gln Gly Ser Gln Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly 
    530                 535                 540                 


Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala 
545                 550                 555                 560 


Ala Ala Ala Ala Ala Ser Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly 
                565                 570                 575     


Ala Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            580                 585                 590         


Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly 
        595                 600                 605             


Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala 
    610                 615                 620                 


Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr 
625                 630                 635                 640 


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                645                 650                 655     


Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser 
            660                 665                 670         


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser 
        675                 680                 685             


Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr 
    690                 695                 700                 


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
705                 710                 715                 720 


Ala Ala Ala Ala Ala Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ala 
                725                 730                 735     


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            740                 745                 750         


Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln Gly Gly Tyr 
        755                 760                 765             


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    770                 775                 780                 


Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Val 
785                 790                 795                 800 


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                805                 810                 815     


Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln Gly Gly Tyr 
            820                 825                 830         


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        835                 840                 845             


Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser 
    850                 855                 860                 


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser 
865                 870                 875                 880 


Gly Gln Gly Ser Gln Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr 
                885                 890                 895     


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            900                 905                 910         


Ala Ala Ala Ala Ser Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ala 
        915                 920                 925             


Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    930                 935                 940                 


Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly 
945                 950                 955                 960 


Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala 
                965                 970                 975     


Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly 
            980                 985                 990         


Gln Gly Ser Gly Gly Ser Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
        995                 1000                 1005             


Ala Ala  Ala Ala Ala Gly Arg  Gly Gln Gly Gly Tyr  Gly Gln Gly 
    1010                 1015                 1020             


Ser Gly  Gly Asn Ala Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
    1025                 1030                 1035             


Ala Ala  Ala Ala Gly Gln Gly  Gly Gln Gly Gly Tyr  Gly Arg Gln 
    1040                 1045                 1050             


Ser Gln  Gly Ala Gly Ser Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
    1055                 1060                 1065             


Ala Ala  Ala Ala Ala Gly Ser  Gly Gln Gly Gly Tyr  Gly Gly Gln 
    1070                 1075                 1080             


Gly Gln  Gly Gly Tyr Gly Gln  Ser Ser Ala Ser Ala  Ser Ala Ala 
    1085                 1090                 1095             


Ala Ser  Ala Ala Ser Thr Val  Ala Asn Ser Val Ser  
    1100                 1105                 1110 


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from internal repeats of Euprosthenops
       australis MaSp1


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Ser

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Tyr

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Gln

<400>  11

Gly Gln Gly Gly Gln Gly Gly Gln Gly Gly Leu Gly Gln Gly Gly Tyr 
1               5                   10                  15      


Gly Gln Gly Ala Gly Ser Ser 
            20              


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from internal repeats of Euprosthenops
       australis MaSp1


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Arg

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Ser

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Gly

<400>  12

Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser 
1               5                   10                  15      


Ser 
    


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from internal repeats of Euprosthenops
       australis MaSp1


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Gln

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Arg

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Ser

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Val

<400>  13

Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Gly Asn 
1               5                   10                  


<210>  14
<211>  100
<212>  PRT
<213>  Euprosthenops sp

<400>  14

Ser Arg Leu Ser Ser Pro Glu Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Asn Ser Ala Ala Leu Ser Ser 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Gly Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Ile His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln Leu Val Gly Gln Ser Val Tyr Gln Ala 
                85                  90                  95      


Leu Gly Glu Phe 
            100 


<210>  15
<211>  98
<212>  PRT
<213>  Euprosthenops australis

<400>  15

Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro Asn 
            20                  25                  30          


Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly Ala 
        35                  40                  45              


Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr Ala 
    50                  55                  60                  


Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser 
65                  70                  75                  80  


Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln Val 
                85                  90                  95      


Met Gly 
        


<210>  16
<211>  99
<212>  PRT
<213>  Argiope trifasciata

<400>  16

Ser Arg Leu Ser Ser Pro Gly Ala Ala Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Thr Ser Leu Val Ser Ser Gly Gly Pro Thr Asn Ser Ala Ala Leu Ser 
            20                  25                  30          


Asn Thr Ile Ser Asn Val Val Ser Gln Ile Ser Ser Ser Asn Pro Gly 
        35                  40                  45              


Leu Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Ile Val Ser 
    50                  55                  60                  


Ala Leu Val His Ile Leu Gly Ser Ala Asn Ile Gly Gln Val Asn Ser 
65                  70                  75                  80  


Ser Gly Val Gly Arg Ser Ala Ser Ile Val Gly Gln Ser Ile Asn Gln 
                85                  90                  95      


Ala Phe Ser 
            


<210>  17
<211>  89
<212>  PRT
<213>  Cyrtophora moluccensis

<400>  17

Ser His Leu Ser Ser Pro Glu Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Ser Thr Asn Ser Ala Ala Leu Pro Asn 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Ser Ser Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Ile His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln Ile Val 
                85                  


<210>  18
<211>  98
<212>  PRT
<213>  Latrodectus geometricus

<400>  18

Ser Ala Leu Ala Ala Pro Ala Thr Ser Ala Arg Ile Ser Ser His Ala 
1               5                   10                  15      


Ser Thr Leu Leu Ser Asn Gly Pro Thr Asn Pro Ala Ser Ile Ser Asn 
            20                  25                  30          


Val Ile Ser Asn Ala Val Ser Gln Ile Ser Ser Ser Asn Pro Gly Ala 
        35                  40                  45              


Ser Ser Cys Asp Val Leu Val Gln Ala Leu Leu Glu Leu Val Thr Ala 
    50                  55                  60                  


Leu Leu Thr Ile Ile Gly Ser Ser Asn Val Gly Asn Val Asn Tyr Asp 
65                  70                  75                  80  


Ser Ser Gly Gln Tyr Ala Gln Val Val Ser Gln Ser Val Gln Asn Ala 
                85                  90                  95      


Phe Val 
        


<210>  19
<211>  98
<212>  PRT
<213>  Latrodectus hesperus

<400>  19

Ser Ala Leu Ser Ala Pro Ala Thr Ser Ala Arg Ile Ser Ser His Ala 
1               5                   10                  15      


Ser Ala Leu Leu Ser Ser Gly Pro Thr Asn Pro Ala Ser Ile Ser Asn 
            20                  25                  30          


Val Ile Ser Asn Ala Val Ser Gln Ile Ser Ser Ser Asn Pro Gly Ala 
        35                  40                  45              


Ser Ala Cys Asp Val Leu Val Gln Ala Leu Leu Glu Leu Val Thr Ala 
    50                  55                  60                  


Leu Leu Thr Ile Ile Gly Ser Ser Asn Ile Gly Ser Val Asn Tyr Asp 
65                  70                  75                  80  


Ser Ser Gly Gln Tyr Ala Gln Val Val Thr Gln Ser Val Gln Asn Val 
                85                  90                  95      


Phe Gly 
        


<210>  20
<211>  93
<212>  PRT
<213>  Macrothele holsti

<400>  20

Ser His Leu Ser Ser Pro Glu Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Gly Gly Ser Thr Asn Ser Ala Ala Leu Pro Asn 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Ser Ser Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Ile His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asp Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln Ile Val Gly Gln Ser Ala 
                85                  90              


<210>  21
<211>  98
<212>  PRT
<213>  Nephila clavipes

<400>  21

Ser Arg Leu Ser Ser Pro Gln Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ala Ser Gly Pro Thr Asn Ser Ala Ala Leu Ser Ser 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Gly Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Ile Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Ile Gln Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln Ile Val Gly Gln Ser Val Tyr Gln Ala 
                85                  90                  95      


Leu Gly 
        


<210>  22
<211>  89
<212>  PRT
<213>  Nephila pilipes

<400>  22

Ser Arg Leu Ser Ser Pro Glu Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Asn Ser Ala Ala Leu Ser Asn 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Ser Ser Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Ile His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln Ile Val 
                85                  


<210>  23
<211>  87
<212>  PRT
<213>  Nephila madagascariensis

<400>  23

Ser Arg Leu Ser Ser Pro Gln Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ala Ser Gly Pro Thr Asn Ser Ala Ala Leu Ser Ser 
            20                  25                  30          


Thr Ile Ser Asn Ala Val Ser Gln Ile Gly Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Ile Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Ile His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln 
                85          


<210>  24
<211>  87
<212>  PRT
<213>  Nephila senegalensis

<400>  24

Ser Arg Leu Ser Ser Pro Glu Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Asn Ser Ala Ala Leu Ser Ser 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Gly Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Ile Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Val His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln 
                85          


<210>  25
<211>  89
<212>  PRT
<213>  Octonoba varians

<400>  25

Ser Arg Leu Ser Ser Pro Glu Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Asn Ser Ala Ala Leu Ser Asn 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Ser Ser Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Pro Ile His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln Ile Val 
                85                  


<210>  26
<211>  89
<212>  PRT
<213>  Psechrus sinensis

<400>  26

Ser Arg Leu Ser Ser Pro Glu Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Asn Ser Ala Ala Leu Pro Asn 
            20                  25                  30          


Thr Ile Ser Asn Val Val Ser Gln Ile Ser Ser Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Ile His Ile Leu Gly Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ala Gly Gln Ala Thr Gln Ile Val 
                85                  


<210>  27
<211>  88
<212>  PRT
<213>  Tetragnatha kauaiensis

<400>  27

Ser Leu Leu Ser Ser Pro Ala Ser Asn Ala Arg Ile Ser Ser Ala Val 
1               5                   10                  15      


Ser Ala Leu Ala Ser Gly Ala Ala Ser Gly Pro Gly Tyr Leu Ser Ser 
            20                  25                  30          


Val Ile Ser Asn Val Val Ser Gln Val Ser Ser Asn Ser Gly Gly Leu 
        35                  40                  45              


Val Gly Cys Asp Thr Leu Val Gln Ala Leu Leu Glu Ala Ala Ala Ala 
    50                  55                  60                  


Leu Val His Val Leu Ala Ser Ser Ser Gly Gly Gln Val Asn Leu Asn 
65                  70                  75                  80  


Thr Ala Gly Tyr Thr Ser Gln Leu 
                85              


<210>  28
<211>  88
<212>  PRT
<213>  Tetragnatha versicolor

<400>  28

Ser Arg Leu Ser Ser Pro Ala Ser Asn Ala Arg Ile Ser Ser Ala Val 
1               5                   10                  15      


Ser Ala Leu Ala Ser Gly Gly Ala Ser Ser Pro Gly Tyr Leu Ser Ser 
            20                  25                  30          


Ile Ile Ser Asn Val Val Ser Gln Val Ser Ser Asn Asn Asp Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Thr Val Val Gln Ala Leu Leu Glu Val Ala Ala Ala 
    50                  55                  60                  


Leu Val His Val Leu Ala Ser Ser Asn Ile Gly Gln Val Asn Leu Asn 
65                  70                  75                  80  


Thr Ala Gly Tyr Thr Ser Gln Leu 
                85              


<210>  29
<211>  89
<212>  PRT
<213>  Araneus bicentenarius

<400>  29

Ser Arg Leu Ser Ser Ser Ala Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Ser Leu Val Ser Ser Gly Pro Thr Thr Pro Ala Ala Leu Ser Asn 
            20                  25                  30          


Thr Ile Ser Ser Ala Val Ser Gln Ile Ser Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Val His Ile Leu Gly Ser Ser Ser Val Gly Gln Ile Asn Tyr Gly 
65                  70                  75                  80  


Ala Ser Ala Gln Tyr Ala Gln Met Val 
                85                  


<210>  30
<211>  97
<212>  PRT
<213>  Argiope amoena

<400>  30

Arg Leu Ser Ser Pro Gln Ala Ser Ser Arg Val Ser Ser Ala Val Ser 
1               5                   10                  15      


Thr Leu Val Ser Ser Gly Pro Thr Asn Pro Ala Ser Leu Ser Asn Ala 
            20                  25                  30          


Ile Gly Ser Val Val Ser Gln Val Ser Ala Ser Asn Pro Gly Leu Pro 
        35                  40                  45              


Ser Cys Asp Val Leu Val Gln Ala Leu Leu Glu Ile Val Ser Ala Leu 
    50                  55                  60                  


Val His Ile Leu Gly Ser Ser Ser Ile Gly Gln Ile Asn Tyr Ser Ala 
65                  70                  75                  80  


Ser Ser Gln Tyr Ala Arg Leu Val Gly Gln Ser Ile Ala Gln Ala Leu 
                85                  90                  95      


Gly 
    


<210>  31
<211>  82
<212>  PRT
<213>  Argiope aurantia

<400>  31

Ser Arg Leu Ser Ser Pro Gln Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Thr Leu Val Ser Ser Gly Pro Thr Asn Pro Ala Ala Leu Ser Asn 
            20                  25                  30          


Ala Ile Ser Ser Val Val Ser Gln Val Ser Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Leu Val Ser Ala 
    50                  55                  60                  


Leu Val His Ile Leu Gly Ser Ser Ser Ile Gly Gln Ile Asn Tyr Ala 
65                  70                  75                  80  


Ala Ser 
        


<210>  32
<211>  98
<212>  PRT
<213>  Argiope trifasciata

<400>  32

Ser Arg Leu Ser Ser Pro Gln Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Thr Leu Val Ser Ser Gly Pro Thr Asn Pro Ala Ser Leu Ser Asn 
            20                  25                  30          


Ala Ile Ser Ser Val Val Ser Gln Val Ser Ser Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Ile Val Ser Ala 
    50                  55                  60                  


Leu Val His Ile Leu Gly Ser Ser Ser Ile Gly Gln Ile Asn Tyr Ala 
65                  70                  75                  80  


Ala Ser Ser Gln Tyr Ala Gln Leu Val Gly Gln Ser Leu Thr Gln Ala 
                85                  90                  95      


Leu Gly 
        


<210>  33
<211>  89
<212>  PRT
<213>  Gasteracantha mammosa

<400>  33

Ser Arg Leu Ser Ser Pro Gln Ala Gly Ala Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Ala Leu Val Ala Ser Gly Pro Thr Ser Pro Ala Ala Val Ser Ser 
            20                  25                  30          


Ala Ile Ser Asn Val Ala Ser Gln Ile Ser Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Ile Val Ser Ala 
    50                  55                  60                  


Leu Val Ser Ile Leu Ser Ser Ala Ser Ile Gly Gln Ile Asn Tyr Gly 
65                  70                  75                  80  


Ala Ser Gly Gln Tyr Ala Ala Met Ile 
                85                  


<210>  34
<211>  90
<212>  PRT
<213>  Latrodectus geometricus

<400>  34

Ser Ala Leu Ser Ser Pro Thr Thr His Ala Arg Ile Ser Ser His Ala 
1               5                   10                  15      


Ser Thr Leu Leu Ser Ser Gly Pro Thr Asn Ser Ala Ala Ile Ser Asn 
            20                  25                  30          


Val Ile Ser Asn Ala Val Ser Gln Val Ser Ala Ser Asn Pro Gly Ser 
        35                  40                  45              


Ser Ser Cys Asp Val Leu Val Gln Ala Leu Leu Glu Leu Ile Thr Ala 
    50                  55                  60                  


Leu Ile Ser Ile Val Asp Ser Ser Asn Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ser Gly Gln Tyr Ala Gln Met Val Gly 
                85                  90  


<210>  35
<211>  98
<212>  PRT
<213>  Latrodectus hesperus

<400>  35

Ser Ala Leu Ser Ser Pro Thr Thr His Ala Arg Ile Ser Ser His Ala 
1               5                   10                  15      


Ser Thr Leu Leu Ser Ser Gly Pro Thr Asn Ala Ala Ala Leu Ser Asn 
            20                  25                  30          


Val Ile Ser Asn Ala Val Ser Gln Val Ser Ala Ser Asn Pro Gly Ser 
        35                  40                  45              


Ser Ser Cys Asp Val Leu Val Gln Ala Leu Leu Glu Ile Ile Thr Ala 
    50                  55                  60                  


Leu Ile Ser Ile Leu Asp Ser Ser Ser Val Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ser Ser Gly Gln Tyr Ala Gln Ile Val Gly Gln Ser Met Gln Gln Ala 
                85                  90                  95      


Met Gly 
        


<210>  36
<211>  97
<212>  PRT
<213>  Nephila clavipes

<400>  36

Ser Arg Leu Ala Ser Pro Asp Ser Gly Ala Arg Val Ala Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Ser Ser Ala Ala Leu Ser Ser 
            20                  25                  30          


Val Ile Ser Asn Ala Val Ser Gln Ile Gly Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Ile Gln Ala Leu Leu Glu Ile Val Ser Ala 
    50                  55                  60                  


Cys Val Thr Ile Leu Ser Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ala Ala Ser Gln Phe Ala Gln Val Val Gly Gln Ser Val Leu Ser Ala 
                85                  90                  95      


Phe 
    


<210>  37
<211>  82
<212>  PRT
<213>  Nephila madagascariensis

<400>  37

Ser Arg Leu Ala Ser Pro Asp Ser Gly Ala Arg Val Ala Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Ser Ser Ala Ala Leu Ser Ser 
            20                  25                  30          


Val Ile Ser Asn Ala Val Ser Gln Ile Gly Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Ile Gln Ala Leu Leu Glu Ile Val Ser Ala 
    50                  55                  60                  


Cys Val Thr Ile Leu Ser Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ala Ala 
        


<210>  38
<211>  82
<212>  PRT
<213>  Nephila senegalensis


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

Ser Arg Leu Ala Ser Pro Asp Ser Gly Ala Arg Val Ala Ser Ala Val 
1               5                   10                  15      


Ser Asn Leu Val Ser Ser Gly Pro Thr Ser Ser Ala Ala Leu Ser Ser 
            20                  25                  30          


Val Ile Xaa Asn Ala Val Ser Gln Ile Gly Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Ile Xaa Ala Leu Leu Glu Ile Val Ser Ala 
    50                  55                  60                  


Cys Val Thr Ile Leu Ser Ser Ser Ser Ile Gly Gln Val Asn Tyr Gly 
65                  70                  75                  80  


Ala Ala 
        


<210>  39
<211>  71
<212>  PRT
<213>  Dolomedes tenebrosus

<400>  39

Ser Arg Leu Ser Ser Pro Glu Ala Ala Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Ser Leu Val Ser Asn Gly Gln Val Asn Val Asp Ala Leu Pro Ser 
            20                  25                  30          


Ile Ile Ser Asn Leu Ser Ser Ser Ile Ser Ala Ser Ala Thr Thr Ala 
        35                  40                  45              


Ser Asp Cys Glu Val Leu Val Gln Val Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Val Gln Ile Val Cys Ser 
65                  70      


<210>  40
<211>  97
<212>  PRT
<213>  Dolomedes tenebrosus

<400>  40

Ser Arg Leu Ser Ser Pro Gln Ala Ala Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Ser Leu Val Ser Asn Gly Gln Val Asn Val Ala Ala Leu Pro Ser 
            20                  25                  30          


Ile Ile Ser Ser Leu Ser Ser Ser Ile Ser Ala Ser Ser Thr Ala Ala 
        35                  40                  45              


Ser Asp Cys Glu Val Leu Val Gln Val Leu Leu Glu Ile Val Ser Ala 
    50                  55                  60                  


Leu Val Gln Ile Val Ser Ser Ala Asn Val Gly Tyr Ile Asn Pro Glu 
65                  70                  75                  80  


Ala Ser Gly Ser Leu Asn Ala Val Gly Ser Ala Leu Ala Ala Ala Met 
                85                  90                  95      


Gly 
    


<210>  41
<211>  93
<212>  PRT
<213>  Araneus diadematus

<400>  41

Asn Arg Leu Ser Ser Ala Gly Ala Ala Ser Arg Val Ser Ser Asn Val 
1               5                   10                  15      


Ala Ala Ile Ala Ser Ala Gly Ala Ala Ala Leu Pro Asn Val Ile Ser 
            20                  25                  30          


Asn Ile Tyr Ser Gly Val Leu Ser Ser Gly Val Ser Ser Ser Glu Ala 
        35                  40                  45              


Leu Ile Gln Ala Leu Leu Glu Val Ile Ser Ala Leu Ile His Val Leu 
    50                  55                  60                  


Gly Ser Ala Ser Ile Gly Asn Val Ser Ser Val Gly Val Asn Ser Ala 
65                  70                  75                  80  


Leu Asn Ala Val Gln Asn Ala Val Gly Ala Tyr Ala Gly 
                85                  90              


<210>  42
<211>  98
<212>  PRT
<213>  Araneus diadematus

<400>  42

Ser Arg Leu Ser Ser Pro Ser Ala Ala Ala Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Leu Val Ser Asn Gly Gly Pro Thr Ser Pro Ala Ala Leu Ser Ser 
            20                  25                  30          


Ser Ile Ser Asn Val Val Ser Gln Ile Ser Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Ile Leu Val Gln Ala Leu Leu Glu Ile Ile Ser Ala 
    50                  55                  60                  


Leu Val His Ile Leu Gly Ser Ala Asn Ile Gly Pro Val Asn Ser Ser 
65                  70                  75                  80  


Ser Ala Gly Gln Ser Ala Ser Ile Val Gly Gln Ser Val Tyr Arg Ala 
                85                  90                  95      


Leu Ser 
        


<210>  43
<211>  98
<212>  PRT
<213>  Araneus diadematus

<400>  43

Ser Arg Leu Ser Ser Pro Ala Ala Ser Ser Arg Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Ser Leu Val Ser Ser Gly Pro Thr Lys His Ala Ala Leu Ser Asn 
            20                  25                  30          


Thr Ile Ser Ser Val Val Ser Gln Val Ser Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Val Leu Val Gln Ala Leu Leu Glu Val Val Ser Ala 
    50                  55                  60                  


Leu Val Ser Ile Leu Gly Ser Ser Ser Ile Gly Gln Ile Asn Tyr Gly 
65                  70                  75                  80  


Ala Ser Ala Gln Tyr Thr Gln Met Val Gly Gln Ser Val Ala Gln Ala 
                85                  90                  95      


Leu Ala 
        


<210>  44
<211>  94
<212>  PRT
<213>  Araneus diadematus

<400>  44

Ser Val Tyr Leu Arg Leu Gln Pro Arg Leu Glu Val Ser Ser Ala Val 
1               5                   10                  15      


Ser Ser Leu Val Ser Ser Gly Pro Thr Asn Gly Ala Ala Val Ser Gly 
            20                  25                  30          


Ala Leu Asn Ser Leu Val Ser Gln Ile Ser Ala Ser Asn Pro Gly Leu 
        35                  40                  45              


Ser Gly Cys Asp Ala Leu Val Gln Ala Leu Leu Glu Leu Val Ser Ala 
    50                  55                  60                  


Leu Val Ala Ile Leu Ser Ser Ala Ser Ile Gly Gln Val Asn Val Ser 
65                  70                  75                  80  


Ser Val Ser Gln Ser Thr Gln Met Ile Ser Gln Ala Leu Ser 
                85                  90                  


<210>  45
<211>  131
<212>  PRT
<213>  Euprosthenops australis

<400>  45

Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile 
        35                  40                  45              


Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala 
                85                  90                  95      


Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe 
            100                 105                 110         


Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met 
        115                 120                 125             


Asn Asp Val 
    130     


<210>  46
<211>  127
<212>  PRT
<213>  Latrodectus geometricus

<400>  46

Gln Ala Asn Thr Pro Trp Ser Ser Lys Gln Asn Ala Asp Ala Phe Ile 
1               5                   10                  15      


Ser Ala Phe Met Thr Ala Ala Ser Gln Ser Gly Ala Phe Ser Ser Asp 
            20                  25                  30          


Gln Ile Asp Asp Met Ser Val Ile Ser Asn Thr Leu Met Ala Ala Met 
        35                  40                  45              


Asp Asn Met Gly Gly Arg Ile Thr Pro Ser Lys Leu Gln Ala Leu Asp 
    50                  55                  60                  


Met Ala Phe Ala Ser Ser Val Ala Glu Ile Ala Ala Val Glu Gly Gln 
65                  70                  75                  80  


Asn Ile Gly Val Thr Thr Asn Ala Ile Ser Asp Ala Leu Thr Ser Ala 
                85                  90                  95      


Phe Tyr Gln Thr Thr Gly Val Val Asn Asn Lys Phe Ile Ser Glu Ile 
            100                 105                 110         


Arg Ser Leu Ile Asn Met Phe Ala Gln Ala Ser Ala Asn Asp Val 
        115                 120                 125         


<210>  47
<211>  127
<212>  PRT
<213>  Latrodectus hesperus

<400>  47

Gln Ala Asn Thr Pro Trp Ser Ser Lys Ala Asn Ala Asp Ala Phe Ile 
1               5                   10                  15      


Asn Ser Phe Ile Ser Ala Ala Ser Asn Thr Gly Ser Phe Ser Gln Asp 
            20                  25                  30          


Gln Met Glu Asp Met Ser Leu Ile Gly Asn Thr Leu Met Ala Ala Met 
        35                  40                  45              


Asp Asn Met Gly Gly Arg Ile Thr Pro Ser Lys Leu Gln Ala Leu Asp 
    50                  55                  60                  


Met Ala Phe Ala Ser Ser Val Ala Glu Ile Ala Ala Ser Glu Gly Gly 
65                  70                  75                  80  


Asp Leu Gly Val Thr Thr Asn Ala Ile Ala Asp Ala Leu Thr Ser Ala 
                85                  90                  95      


Phe Tyr Gln Thr Thr Gly Val Val Asn Ser Arg Phe Ile Ser Glu Ile 
            100                 105                 110         


Arg Ser Leu Ile Gly Met Phe Ala Gln Ala Ser Ala Asn Asp Val 
        115                 120                 125         


<210>  48
<211>  130
<212>  PRT
<213>  Nephila clavipes

<400>  48

Gln Asn Thr Pro Trp Ser Ser Thr Glu Leu Ala Asp Ala Phe Ile Asn 
1               5                   10                  15      


Ala Phe Met Asn Glu Ala Gly Arg Thr Gly Ala Phe Thr Ala Asp Gln 
            20                  25                  30          


Leu Asp Asp Met Ser Thr Ile Gly Asp Thr Ile Lys Thr Ala Met Asp 
        35                  40                  45              


Lys Met Ala Arg Ser Asn Lys Ser Ser Lys Gly Lys Leu Gln Ala Leu 
    50                  55                  60                  


Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Val Glu Gln 
65                  70                  75                  80  


Gly Gly Leu Ser Val Asp Ala Lys Thr Asn Ala Ile Ala Asp Ser Leu 
                85                  90                  95      


Asn Ser Ala Phe Tyr Gln Thr Thr Gly Ala Ala Asn Pro Gln Phe Val 
            100                 105                 110         


Asn Glu Ile Arg Ser Leu Ile Asn Met Phe Ala Gln Ser Ser Ala Asn 
        115                 120                 125             


Glu Val 
    130 


<210>  49
<211>  131
<212>  PRT
<213>  Argiope trifasciata

<400>  49

Gln Gly Ala Thr Pro Trp Glu Asn Ser Gln Leu Ala Glu Ser Phe Ile 
1               5                   10                  15      


Ser Arg Phe Leu Arg Phe Ile Gly Gln Ser Gly Ala Phe Ser Pro Asn 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Ser Ile Gly Asp Thr Leu Lys Thr Ala Ile 
        35                  40                  45              


Glu Lys Met Ala Gln Ser Arg Lys Ser Ser Lys Ser Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Val Ala Glu 
65                  70                  75                  80  


Gln Gly Gly Leu Ser Leu Glu Ala Lys Thr Asn Ala Ile Ala Ser Ala 
                85                  90                  95      


Leu Ser Ala Ala Phe Leu Glu Thr Thr Gly Tyr Val Asn Gln Gln Phe 
            100                 105                 110         


Val Asn Glu Ile Lys Thr Leu Ile Phe Met Ile Ala Gln Ala Ser Ser 
        115                 120                 125             


Asn Glu Ile 
    130     


<210>  50
<211>  124
<212>  PRT
<213>  Latrodectus geometricus

<400>  50

Leu Arg Trp Ser Ser Lys Asp Asn Ala Asp Arg Phe Ile Asn Ala Phe 
1               5                   10                  15      


Leu Gln Ala Ala Ser Asn Ser Gly Ala Phe Ser Ser Asp Gln Val Asp 
            20                  25                  30          


Asp Met Ser Val Ile Gly Asn Thr Leu Met Thr Ala Met Asp Asn Met 
        35                  40                  45              


Gly Gly Arg Ile Thr Pro Ser Lys Leu Gln Ala Leu Asp Met Ala Phe 
    50                  55                  60                  


Ala Ser Ser Val Ala Glu Ile Ala Val Ala Asp Gly Gln Asn Val Gly 
65                  70                  75                  80  


Gly Ala Thr Asn Ala Ile Ser Asn Ala Leu Arg Ser Ala Phe Tyr Gln 
                85                  90                  95      


Thr Thr Gly Val Val Asn Asn Gln Phe Ile Ser Glu Ile Ser Asn Leu 
            100                 105                 110         


Ile Asn Met Phe Ala Gln Val Ser Ala Asn Glu Val 
        115                 120                 


<210>  51
<211>  127
<212>  PRT
<213>  Latrodectus hesperus

<400>  51

Gln Ala Asn Thr Pro Trp Ser Ser Lys Glu Asn Ala Asp Ala Phe Ile 
1               5                   10                  15      


Gly Ala Phe Met Asn Ala Ala Ser Gln Ser Gly Ala Phe Ser Ser Asp 
            20                  25                  30          


Gln Ile Asp Asp Met Ser Val Ile Ser Asn Thr Leu Met Ala Ala Met 
        35                  40                  45              


Asp Asn Met Gly Gly Arg Ile Thr Gln Ser Lys Leu Gln Ala Leu Asp 
    50                  55                  60                  


Met Ala Phe Ala Ser Ser Val Ala Glu Ile Ala Val Ala Asp Gly Gln 
65                  70                  75                  80  


Asn Val Gly Ala Ala Thr Asn Ala Ile Ser Asp Ala Leu Arg Ser Ala 
                85                  90                  95      


Phe Tyr Gln Thr Thr Gly Val Val Asn Asn Gln Phe Ile Thr Gly Ile 
            100                 105                 110         


Ser Ser Leu Ile Gly Met Phe Ala Gln Val Ser Gly Asn Glu Val 
        115                 120                 125         


<210>  52
<211>  131
<212>  PRT
<213>  Nephila inaurata madagascariensis

<400>  52

Gln Ala Asn Thr Pro Trp Ser Asp Thr Ala Thr Ala Asp Ala Phe Ile 
1               5                   10                  15      


Gln Asn Phe Leu Gly Ala Val Ser Gly Ser Gly Ala Phe Thr Pro Asp 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Thr Val Gly Asp Thr Ile Met Ser Ala Met 
        35                  40                  45              


Asp Lys Met Ala Arg Ser Asn Lys Ser Ser Lys Ser Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Val Glu 
65                  70                  75                  80  


Gln Gly Gly Gln Ser Met Asp Val Lys Thr Asn Ala Ile Ala Asn Ala 
                85                  90                  95      


Leu Asp Ser Ala Phe Tyr Met Thr Thr Gly Ser Thr Asn Gln Gln Phe 
            100                 105                 110         


Val Asn Glu Met Arg Ser Leu Ile Asn Met Leu Ser Ala Ala Ala Val 
        115                 120                 125             


Asn Glu Val 
    130     


<210>  53
<211>  131
<212>  PRT
<213>  Nephila clavipes

<400>  53

Gln Ala Arg Ser Pro Trp Ser Asp Thr Ala Thr Ala Asp Ala Phe Ile 
1               5                   10                  15      


Gln Asn Phe Leu Ala Ala Val Ser Gly Ser Gly Ala Phe Thr Ser Asp 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Thr Ile Gly Asp Thr Ile Met Ser Ala Met 
        35                  40                  45              


Asp Lys Met Ala Arg Ser Asn Lys Ser Ser Gln His Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Val Glu 
65                  70                  75                  80  


Gln Gly Gly Met Ser Met Ala Val Lys Thr Asn Ala Ile Val Asp Gly 
                85                  90                  95      


Leu Asn Ser Ala Phe Tyr Met Thr Thr Gly Ala Ala Asn Pro Gln Phe 
            100                 105                 110         


Val Asn Glu Met Arg Ser Leu Ile Ser Met Ile Ser Ala Ala Ser Ala 
        115                 120                 125             


Asn Glu Val 
    130     


<210>  54
<211>  129
<212>  PRT
<213>  Argiope bruennichi

<400>  54

Ala Val Pro Ser Val Phe Ser Ser Pro Asn Leu Ala Ser Gly Phe Leu 
1               5                   10                  15      


Gln Cys Leu Thr Phe Gly Ile Gly Asn Ser Pro Ala Phe Pro Thr Gln 
            20                  25                  30          


Glu Gln Gln Asp Leu Asp Ala Ile Ala Gln Val Ile Leu Asn Ala Val 
        35                  40                  45              


Ser Ser Asn Thr Gly Ala Thr Ala Ser Ala Arg Ala Gln Ala Leu Ser 
    50                  55                  60                  


Thr Ala Leu Ala Ser Ser Leu Thr Asp Leu Leu Ile Ala Glu Ser Ala 
65                  70                  75                  80  


Glu Ser Asn Tyr Ser Asn Gln Leu Ser Glu Leu Thr Gly Ile Leu Ser 
                85                  90                  95      


Asp Cys Phe Ile Gln Thr Thr Gly Ser Asp Asn Pro Ala Phe Val Ser 
            100                 105                 110         


Arg Ile Gln Ser Leu Ile Ser Val Leu Ser Gln Asn Ala Asp Thr Asn 
        115                 120                 125             


Ile 
    


<210>  55
<211>  129
<212>  PRT
<213>  Nephila clavata

<400>  55

Pro Val Pro Ser Val Phe Ser Ser Pro Ser Leu Ala Ser Gly Phe Leu 
1               5                   10                  15      


Gly Cys Leu Thr Thr Gly Ile Gly Leu Ser Pro Ala Phe Pro Phe Gln 
            20                  25                  30          


Glu Gln Gln Asp Leu Asp Asp Leu Ala Lys Val Ile Leu Ser Ala Val 
        35                  40                  45              


Thr Ser Asn Thr Asp Thr Ser Lys Ser Ala Arg Ala Gln Ala Leu Ser 
    50                  55                  60                  


Thr Ala Leu Ala Ser Ser Leu Ala Asp Leu Leu Ile Ser Glu Ser Ser 
65                  70                  75                  80  


Gly Ser Ser Tyr Gln Thr Gln Ile Ser Ala Leu Thr Asn Ile Leu Ser 
                85                  90                  95      


Asp Cys Phe Val Thr Thr Thr Gly Ser Asn Asn Pro Ala Phe Val Ser 
            100                 105                 110         


Arg Val Gln Thr Leu Ile Gly Val Leu Ser Gln Ser Ser Ser Asn Ala 
        115                 120                 125             


Ile 
    


<210>  56
<211>  128
<212>  PRT
<213>  Latrodectus hesperus

<400>  56

Ala Ser Val Asn Ile Phe Asn Ser Pro Asn Ala Ala Thr Ser Phe Leu 
1               5                   10                  15      


Asn Cys Leu Arg Ser Asn Ile Glu Ser Ser Pro Ala Phe Pro Phe Gln 
            20                  25                  30          


Glu Gln Ala Asp Leu Asp Ser Ile Ala Glu Val Ile Leu Ser Asp Val 
        35                  40                  45              


Ser Ser Val Asn Thr Ala Ser Ser Ala Thr Ser Leu Ala Leu Ser Thr 
    50                  55                  60                  


Ala Leu Ala Ser Ser Leu Ala Glu Leu Leu Val Thr Glu Ser Ala Glu 
65                  70                  75                  80  


Glu Asp Ile Asp Asn Gln Val Val Ala Leu Ser Thr Ile Leu Ser Gln 
                85                  90                  95      


Cys Phe Val Glu Thr Thr Gly Ser Pro Asn Pro Ala Phe Val Ala Ser 
            100                 105                 110         


Val Lys Ser Leu Leu Gly Val Leu Ser Gln Ser Ala Ser Asn Tyr Glu 
        115                 120                 125             


<210>  57
<211>  130
<212>  PRT
<213>  Nephila clavipes

<400>  57

Ile Ala Asn Ser Pro Phe Ser Asn Pro Asn Thr Ala Glu Ala Phe Ala 
1               5                   10                  15      


Arg Ser Phe Val Ser Asn Ile Val Ser Ser Gly Glu Phe Gly Ala Gln 
            20                  25                  30          


Gly Ala Glu Asp Phe Asp Asp Ile Ile Gln Ser Leu Ile Gln Ala Gln 
        35                  40                  45              


Ser Met Gly Lys Gly Arg His Asp Thr Lys Ala Lys Ala Lys Ala Met 
    50                  55                  60                  


Gln Val Ala Leu Ala Ser Ser Ile Ala Glu Leu Val Ile Ala Glu Ser 
65                  70                  75                  80  


Ser Gly Gly Asp Val Gln Arg Lys Thr Asn Val Ile Ser Asn Ala Leu 
                85                  90                  95      


Arg Asn Ala Leu Met Ser Thr Thr Gly Ser Pro Asn Glu Glu Phe Val 
            100                 105                 110         


His Glu Val Gln Asp Leu Ile Gln Met Leu Ser Gln Glu Gln Ile Asn 
        115                 120                 125             


Glu Val 
    130 


<210>  58
<211>  130
<212>  PRT
<213>  Nephila inaurata madagascariensis

<400>  58

Ile Val Asn Ser Pro Phe Ser Asn Pro Asn Thr Ala Glu Ala Phe Ala 
1               5                   10                  15      


Arg Ser Phe Val Ser Asn Val Val Ser Ser Gly Glu Phe Gly Ala Gln 
            20                  25                  30          


Gly Ala Glu Asp Phe Asp Asp Ile Ile Gln Ser Leu Ile Gln Ala Gln 
        35                  40                  45              


Ser Met Gly Lys Gly Arg His Asp Thr Lys Ala Lys Ala Lys Ala Met 
    50                  55                  60                  


Gln Val Ala Leu Ala Ser Ser Ile Ala Glu Leu Val Ile Ala Glu Ser 
65                  70                  75                  80  


Ser Gly Gly Asp Val Gln Arg Lys Thr Asn Val Ile Ser Asn Ala Leu 
                85                  90                  95      


Arg Asn Ala Leu Met Ser Thr Thr Gly Ser Pro Asn Glu Glu Phe Val 
            100                 105                 110         


His Glu Val Gln Asp Leu Ile Gln Met Leu Ser Gln Glu Gln Ile Asn 
        115                 120                 125             


Glu Val 
    130 


<210>  59
<211>  1778
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  59
atgggcagca gcggccatca tcatcatcat catatggagg tgcagctgtt ggagtctggg       60

ggaggcttgg tacagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc      120

ttcagtagtt atgaaatgaa ctgggtccgc caggctccag ggaaggggct ggagtgggtc      180

tcaggcatta gtggtagtgg tggtttcaca tactacgcag actccgtgaa gggccgattc      240

accatctcca gagacaattc caagaacacg ctgtatctgc aaatgaacag cctgagagcc      300

gaggacactg ccatgtatta ctgtgcgaga gaggggtacc aggatgcttt tgatatctgg      360

ggccagggta cactggtcac cgtgagcagc ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gatcgcagtc tgtgctgact cagccaccct cagcgtctgg gacccccggg      480

cagagggtca ccatctcctg cactgggagc agctccaaca tcggggcagg ttatgatgta      540

cactggtatc agcagctccc aggaacggcc cccaaactcc tcatctatag taataatcag      600

cggccctcag gggtccctga ccgattctct ggctccaagt ctggcacctc agcctccctg      660

gccatcagtg ggctccggtc cgaggatgag gctgattatt actgtgcagc atgggatgac      720

agcctgagtg gtccgccttg cgtgttcggc ggaggaacca agctgacggt cctaggtgaa      780

caaaaactca tctcagaaga ggatctgtct ggatcagcgg ctgcagggaa ttcaggtcaa      840

ggtggatatg gtggactagg tcaaggagga tatggacaag gtgcaggaag ttctgcagcc      900

gctgccgccg ccgcagcagc cgccgcagca ggtggacaag gtggacaagg tcaaggagga      960

tatggacaag gttcaggagg ttctgcagcc gccgccgccg ccgcagcagc agcagcagct     1020

gcagcagctg gacgaggtca aggaggatat ggtcaaggtt ctggaggtaa tgctgctgcc     1080

gcagccgctg ccgccgccgc cgccgctgca gcagccggac agggaggtca aggtggatat     1140

ggtagacaaa gccaaggtgc tggttccgct gctgctgctg ctgctgctgc tgccgctgct     1200

gctgctgcag gatctggaca aggtggatac ggtggacaag gtcaaggagg ttatggtcag     1260

agtagtgctt ctgcttcagc tgctgcgtca gctgctagta ctgtagctaa ttcggtgagt     1320

cgcctctcat cgccttccgc agtatctcga gtttcttcag cagtttctag cttggtttca     1380

aatggtcaag tgaatatggc agcgttacct aatatcattt ccaacatttc ttcttctgtc     1440

agtgcatctg ctcctggtgc ttctggatgt gaggtcatag tgcaagctct actcgaagtc     1500

atcactgctc ttgttcaaat cgttagttct tctagtgttg gatatattaa tccatctgct     1560

gtgaaccaaa ttactaatgt tgttgctaat gccatggctc aagtaatggg ctaatgataa     1620

gcttctcgag ggcctcccag gccggcgcgc cccaccgctg agcaataact agcataaccc     1680

cttggggcct ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatccgga     1740

ttggcgaatg ggacgcgccc tgtagcggcg cattaagc                             1778


<210>  60
<211>  1599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  60
atgcatcatc atcatcatca tggtcaaggt ggatatggtg gactaggtca aggaggatat       60

ggacaaggtg caggaagttc tgcagccgct gccgccgccg cagcagccgc cgcagcaggt      120

ggacaaggtg gacaaggtca aggaggatat ggacaaggtt caggaggttc tgcagccgcc      180

gccgccgccg cagcagcagc agcagctgca gcagctggac gaggtcaagg aggatatggt      240

caaggttctg gaggtaatgc tgctgccgca gccgctgccg ccgccgccgc cgctgcagca      300

gccggacagg gaggtcaagg tggatatggt agacaaagcc aaggtgctgg ttccgctgct      360

gctgctgctg ctgctgctgc cgctgctgct gctgcaggat ctggacaagg tggatacggt      420

ggacaaggtc aaggaggtta tggtcagagt agtgcttctg cttcagctgc tgcgtcagct      480

gctagtactg tagctaattc ggtgagtcgc ctctcatcgc cttccgcagt atctcgagtt      540

tcttcagcag tttctagctt ggtttcaaat ggtcaagtga atatggcagc gttacctaat      600

atcatttcca acatttcttc ttctgtcagt gcatctgctc ctggtgcttc tggatgtgag      660

gtcatagtgc aagctctact cgaagtcatc actgctcttg ttcaaatcgt tagttcttct      720

agtgttggat atattaatcc atctgctgtg aaccaaatta ctaatgttgt tgctaatgcc      780

atggctcaag taatgggcgg gaattcagag gtgcagctgt tggagtctgg gggaggcttg      840

gtacagcctg gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt      900

tatgaaatga actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcaggcatt      960

agtggtagtg gtggtttcac atactacgca gactccgtga agggccgatt caccatctcc     1020

agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc cgaggacact     1080

gccatgtatt actgtgcgag agaggggtac caggatgctt ttgatatctg gggccagggt     1140

acactggtca ccgtgagcag cggtggaggc ggttcaggcg gaggtggatc cggcggtggc     1200

ggatcgcagt ctgtgctgac tcagccaccc tcagcgtctg ggacccccgg gcagagggtc     1260

accatctcct gcactgggag cagctccaac atcggggcag gttatgatgt acactggtat     1320

cagcagctcc caggaacggc ccccaaactc ctcatctata gtaataatca gcggccctca     1380

ggggtccctg accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt     1440

gggctccggt ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt     1500

ggtccgcctt gcgtgttcgg cggaggaacc aagctgacgg tcctaggtga acaaaaactc     1560

atctcagaag aggatctgtc tggatcagcg gctgcataa                            1599


<210>  61
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  61

Met Gly Ser Ser Gly His His His His His His Met Glu Val Gln Leu 
1               5                   10                  15      


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            20                  25                  30          


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn Trp 
        35                  40                  45              


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser 
    50                  55                  60                  


Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
65                  70                  75                  80  


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
                85                  90                  95      


Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Gly 
            100                 105                 110         


Tyr Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
145                 150                 155                 160 


Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala 
                165                 170                 175     


Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
    210                 215                 220                 


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
225                 230                 235                 240 


Ser Leu Ser Gly Pro Pro Cys Val Phe Gly Gly Gly Thr Lys Leu Thr 
                245                 250                 255     


Val Leu Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly Ser 
            260                 265                 270         


Ala Ala Ala Gly Asn Ser Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln 
        275                 280                 285             


Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly 
305                 310                 315                 320 


Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala 
                325                 330                 335     


Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln 
            340                 345                 350         


Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        355                 360                 365             


Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln Ser 
    370                 375                 380                 


Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gly Gln Gly Gln Gly 
                405                 410                 415     


Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala 
            420                 425                 430         


Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala Val 
        435                 440                 445             


Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln Val 
    450                 455                 460                 


Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser Val 
465                 470                 475                 480 


Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln Ala 
                485                 490                 495     


Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser Ser 
            500                 505                 510         


Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val Val 
        515                 520                 525             


Ala Asn Ala Met Ala Gln Val Met Gly 
    530                 535         


<210>  62
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  62

Met His His His His His His Gly Gln Gly Gly Tyr Gly Gly Leu Gly 
1               5                   10                  15      


Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly 
        35                  40                  45              


Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly 
65                  70                  75                  80  


Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln 
            100                 105                 110         


Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gly Gln Gly Gln 
    130                 135                 140                 


Gly Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala 
145                 150                 155                 160 


Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala 
                165                 170                 175     


Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln 
            180                 185                 190         


Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser 
        195                 200                 205             


Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln 
    210                 215                 220                 


Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser 
225                 230                 235                 240 


Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val 
                245                 250                 255     


Val Ala Asn Ala Met Ala Gln Val Met Gly Gly Asn Ser Glu Val Gln 
            260                 265                 270         


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        275                 280                 285             


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn 
    290                 295                 300                 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
305                 310                 315                 320 


Ser Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
                325                 330                 335     


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            340                 345                 350         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu 
        355                 360                 365             


Gly Tyr Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro 
                405                 410                 415     


Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly 
            420                 425                 430         


Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
        435                 440                 445             


Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
    450                 455                 460                 


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
465                 470                 475                 480 


Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                485                 490                 495     


Asp Ser Leu Ser Gly Pro Pro Cys Val Phe Gly Gly Gly Thr Lys Leu 
            500                 505                 510         


Thr Val Leu Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly 
        515                 520                 525             


Ser Ala Ala Ala 
    530         


<210>  63
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  63

Met Gly Ser Ser Gly His His His His His His Met Glu Val Gln Leu 
1               5                   10                  15      


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            20                  25                  30          


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn Trp 
        35                  40                  45              


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser 
    50                  55                  60                  


Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
65                  70                  75                  80  


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
                85                  90                  95      


Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Gly 
            100                 105                 110         


Tyr Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
145                 150                 155                 160 


Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala 
                165                 170                 175     


Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
    210                 215                 220                 


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
225                 230                 235                 240 


Ser Leu Ser Gly Pro Pro Cys Val Phe Gly Gly Gly Thr Lys Leu Thr 
                245                 250                 255     


Val Leu Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly Ser 
            260                 265                 270         


Ala Ala Ala Ser Ala Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu 
        275                 280                 285             


Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu 
    290                 295                 300                 


Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser 
305                 310                 315                 320 


Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys 
                325                 330                 335     


Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln 
            340                 345                 350         


Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn 
        355                 360                 365             


Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln Val Met Gly 
    370                 375                 380             


<210>  64
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  64

Met His His His His His His Ser Ala Ala Ser Thr Val Ala Asn Ser 
1               5                   10                  15      


Val Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala 
            20                  25                  30          


Val Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro 
        35                  40                  45              


Asn Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly 
    50                  55                  60                  


Ala Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr 
65                  70                  75                  80  


Ala Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro 
                85                  90                  95      


Ser Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln 
            100                 105                 110         


Val Met Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
        115                 120                 125             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    130                 135                 140                 


Ser Ser Tyr Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
145                 150                 155                 160 


Glu Trp Val Ser Gly Ile Ser Gly Ser Gly Gly Phe Thr Tyr Tyr Ala 
                165                 170                 175     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            180                 185                 190         


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met 
        195                 200                 205             


Tyr Tyr Cys Ala Arg Glu Gly Tyr Gln Asp Ala Phe Asp Ile Trp Gly 
    210                 215                 220                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro 
                245                 250                 255     


Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly 
            260                 265                 270         


Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln 
        275                 280                 285             


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg 
    290                 295                 300                 


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
305                 310                 315                 320 


Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr 
                325                 330                 335     


Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Pro Cys Val Phe 
            340                 345                 350         


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu Gln Lys Leu Ile Ser 
        355                 360                 365             


Glu Glu Asp Leu Ser Gly Ser Ala Ala Ala 
    370                 375             


<210>  65
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  65

Met Gly Ser Ser Gly His His His His His His Met Glu Val Gln Leu 
1               5                   10                  15      


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            20                  25                  30          


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn Trp 
        35                  40                  45              


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser 
    50                  55                  60                  


Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
65                  70                  75                  80  


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
                85                  90                  95      


Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Gly 
            100                 105                 110         


Tyr Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
145                 150                 155                 160 


Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala 
                165                 170                 175     


Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
    210                 215                 220                 


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
225                 230                 235                 240 


Ser Leu Ser Gly Pro Pro Cys Val Phe Gly Gly Gly Thr Lys Leu Thr 
                245                 250                 255     


Val Leu Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly Ser 
            260                 265                 270         


Ala Ala Ala Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu 
        275                 280                 285             


Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe 
    290                 295                 300                 


Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met Val 
305                 310                 315                 320 


Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Lys 
                325                 330                 335     


Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala 
            340                 345                 350         


Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile 
        355                 360                 365             


Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn 
    370                 375                 380                 


Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln 
385                 390                 395                 400 


Ala Gly Met Asn Asp Val Ser Ala Ser Ala Ser Ala Gly Ala Ser Ala 
                405                 410                 415     


Ala Ala Ser Ala Gly Ala Gly Ser Gly Asn Ser Gly Ile Gln Gly Tyr 
            420                 425                 430         


Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala Ser Thr 
        435                 440                 445             


Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg 
    450                 455                 460                 


Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met 
465                 470                 475                 480 


Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala 
                485                 490                 495     


Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu 
            500                 505                 510         


Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly 
        515                 520                 525             


Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn 
    530                 535                 540                 


Ala Met Ala Gln Val Met Gly 
545                 550     


<210>  66
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  66

His His His His His His Met Ser His Thr Thr Pro Trp Thr Asn Pro 
1               5                   10                  15      


Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser 
            20                  25                  30          


Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala 
        35                  40                  45              


Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr 
    50                  55                  60                  


Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met 
65                  70                  75                  80  


Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys 
                85                  90                  95      


Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr 
            100                 105                 110         


Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser 
        115                 120                 125             


Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Ser Ala Ser Ala 
    130                 135                 140                 


Gly Ala Ser Ala Ala Ala Ser Ala Gly Ala Gly Ser Gly Asn Ser Gly 
145                 150                 155                 160 


Ile Gln Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser 
                165                 170                 175     


Ala Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser 
            180                 185                 190         


Ala Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly 
        195                 200                 205             


Gln Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser 
    210                 215                 220                 


Ser Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val 
225                 230                 235                 240 


Gln Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser 
                245                 250                 255     


Ser Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn 
            260                 265                 270         


Val Val Ala Asn Ala Met Ala Gln Val Met Gly Glu Val Gln Leu Leu 
        275                 280                 285             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    290                 295                 300                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn Trp Val 
305                 310                 315                 320 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Gly 
                325                 330                 335     


Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            340                 345                 350         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        355                 360                 365             


Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Gly Tyr 
    370                 375                 380                 


Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
            420                 425                 430         


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
        435                 440                 445             


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
    450                 455                 460                 


Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
465                 470                 475                 480 


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
                485                 490                 495     


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
            500                 505                 510         


Leu Ser Gly Pro Pro Cys Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        515                 520                 525             


Leu Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly Ser Ala 
    530                 535                 540                 


Ala Ala 
545     


<210>  67
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  67

Met Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Gly Ile Ser Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Gly Tyr Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala 
    130                 135                 140                 


Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
145                 150                 155                 160 


Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro 
                165                 170                 175     


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Pro Cys Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu Gly Glu Gln Lys Leu Ile Ser Glu Glu 
                245                 250                 255     


Asp Leu Ser Gly Ser Ala Ala Ala Met Lys Ala Ser His Thr Thr Pro 
            260                 265                 270         


Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln 
        275                 280                 285             


Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met 
    290                 295                 300                 


Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala 
305                 310                 315                 320 


Gln Gly Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe 
                325                 330                 335     


Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser 
            340                 345                 350         


Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe 
        355                 360                 365             


Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr 
    370                 375                 380                 


Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala 
385                 390                 395                 400 


Ser Ala Ser Ala Gly Ala Ser Ala Ala Ala Ser Ala Gly Ala Ala Ser 
                405                 410                 415     


Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly Tyr Gly Gln Gly 
            420                 425                 430         


Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        435                 440                 445             


Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly 
    450                 455                 460                 


Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
465                 470                 475                 480 


Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Asn Ala 
                485                 490                 495     


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln 
            500                 505                 510         


Gly Gly Gln Gly Gly Tyr Gly Arg Gln Ser Gln Gly Ala Gly Ser Ala 
        515                 520                 525             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ser Gly 
    530                 535                 540                 


Gln Gly Gly Tyr Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Ser Ser 
545                 550                 555                 560 


Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala Ser Thr Val Ala Asn Ser 
                565                 570                 575     


Val Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala 
            580                 585                 590         


Val Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro 
        595                 600                 605             


Asn Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly 
    610                 615                 620                 


Ala Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr 
625                 630                 635                 640 


Ala Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro 
                645                 650                 655     


Ser Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln 
            660                 665                 670         


Val Met Gly Lys Leu Ala Ala Ala Leu Glu His His His His His His 
        675                 680                 685             


<210>  68
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  68

Met Gly Ser Ser Gly His His His His His His Met Lys Ala Ser His 
1               5                   10                  15      


Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser 
            20                  25                  30          


Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu 
        35                  40                  45              


Asp Asp Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser 
    50                  55                  60                  


Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn 
65                  70                  75                  80  


Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly 
                85                  90                  95      


Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser 
            100                 105                 110         


Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn 
        115                 120                 125             


Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp 
    130                 135                 140                 


Val Ser Ala Ser Ala Ser Ala Gly Ala Ser Ala Ala Ala Ser Ala Gly 
145                 150                 155                 160 


Ala Ala Ser Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly Tyr 
                165                 170                 175     


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln 
        195                 200                 205             


Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    210                 215                 220                 


Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly 
225                 230                 235                 240 


Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                245                 250                 255     


Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln Ser Gln Gly Ala 
            260                 265                 270         


Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Gly Ser Gly Gln Gly Gly Tyr Gly Gly Gln Gly Gln Gly Gly Tyr Gly 
    290                 295                 300                 


Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala Ser Thr Val 
305                 310                 315                 320 


Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val 
                325                 330                 335     


Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala 
            340                 345                 350         


Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser 
        355                 360                 365             


Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu 
    370                 375                 380                 


Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr 
385                 390                 395                 400 


Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala 
                405                 410                 415     


Met Ala Gln Val Met Gly Lys Leu Ala Ala Ala Leu Glu Glu Val Gln 
            420                 425                 430         


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        435                 440                 445             


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn 
    450                 455                 460                 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
465                 470                 475                 480 


Ser Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
                485                 490                 495     


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            500                 505                 510         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu 
        515                 520                 525             


Gly Tyr Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 
    530                 535                 540                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro 
                565                 570                 575     


Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly 
            580                 585                 590         


Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
        595                 600                 605             


Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
    610                 615                 620                 


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
625                 630                 635                 640 


Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
                645                 650                 655     


Asp Ser Leu Ser Gly Pro Pro Cys Val Phe Gly Gly Gly Thr Lys Leu 
            660                 665                 670         


Thr Val Leu Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly 
        675                 680                 685             


Ser Ala Ala Ala 
    690         


<210>  69
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  69

Met Gly Ser Ser Gly His His His His His His Met Glu Val Gln Leu 
1               5                   10                  15      


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            20                  25                  30          


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn Trp 
        35                  40                  45              


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser 
    50                  55                  60                  


Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
65                  70                  75                  80  


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
                85                  90                  95      


Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Gly 
            100                 105                 110         


Tyr Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
145                 150                 155                 160 


Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala 
                165                 170                 175     


Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
    210                 215                 220                 


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
225                 230                 235                 240 


Ser Leu Ser Gly Pro Pro Cys Val Phe Gly Gly Gly Thr Lys Leu Thr 
                245                 250                 255     


Val Leu Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly Ser 
            260                 265                 270         


Ala Ala Ala Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu 
        275                 280                 285             


Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe 
    290                 295                 300                 


Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met Val 
305                 310                 315                 320 


Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Lys 
                325                 330                 335     


Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala 
            340                 345                 350         


Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile 
        355                 360                 365             


Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn 
    370                 375                 380                 


Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln 
385                 390                 395                 400 


Ala Gly Met Asn Asp Gly Gly Gly Thr Pro Trp Thr Asn Pro Gly Leu 
                405                 410                 415     


Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro 
            420                 425                 430         


Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser 
        435                 440                 445             


Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro 
    450                 455                 460                 


Asn Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu 
465                 470                 475                 480 


Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser 
                485                 490                 495     


Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val 
            500                 505                 510         


Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe 
        515                 520                 525             


Ala Gln Ala Gly Met Asn Asp Val Ser Ala Leu Glu Ala Leu Phe Gln 
    530                 535                 540                 


Gly Pro Asn Ser Gly Asn Ser Gly Ile Gln Gly Tyr Gly Gln Ser Ser 
545                 550                 555                 560 


Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala Ser Thr Val Ala Asn Ser 
                565                 570                 575     


Val Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala 
            580                 585                 590         


Val Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro 
        595                 600                 605             


Asn Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly 
    610                 615                 620                 


Ala Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr 
625                 630                 635                 640 


Ala Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro 
                645                 650                 655     


Ser Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln 
            660                 665                 670         


Val Met Gly 
        675 


<210>  70
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  70

Met Gly His His His His His His Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser His His His His His His Met Ser His Thr Thr Pro Trp Thr 
            20                  25                  30          


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
        35                  40                  45              


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr 
    50                  55                  60                  


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
65                  70                  75                  80  


Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
                85                  90                  95      


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
            100                 105                 110         


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
        115                 120                 125             


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
    130                 135                 140                 


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Gly Gly Gly Thr Pro 
145                 150                 155                 160 


Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln 
                165                 170                 175     


Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met 
            180                 185                 190         


Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala 
        195                 200                 205             


Gln Gly Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe 
    210                 215                 220                 


Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser 
225                 230                 235                 240 


Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe 
                245                 250                 255     


Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr 
            260                 265                 270         


Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala 
        275                 280                 285             


Leu Glu Ala Leu Phe Gln Gly Pro Asn Ser Gly Asn Ser Gly Ile Gln 
    290                 295                 300                 


Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala 
305                 310                 315                 320 


Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala Val 
                325                 330                 335     


Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln Val 
            340                 345                 350         


Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser Val 
        355                 360                 365             


Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln Ala 
    370                 375                 380                 


Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser Ser 
385                 390                 395                 400 


Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val Val 
                405                 410                 415     


Ala Asn Ala Met Ala Gln Val Met Gly Glu Val Gln Leu Leu Glu Ser 
            420                 425                 430         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        435                 440                 445             


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn Trp Val Arg Gln 
    450                 455                 460                 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Gly Ser Gly 
465                 470                 475                 480 


Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                485                 490                 495     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            500                 505                 510         


Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Gly Tyr Gln Asp 
        515                 520                 525             


Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    530                 535                 540                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser 
545                 550                 555                 560 


Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val 
                565                 570                 575     


Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
            580                 585                 590         


Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        595                 600                 605             


Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 
    610                 615                 620                 


Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser 
625                 630                 635                 640 


Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser 
                645                 650                 655     


Gly Pro Pro Cys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            660                 665                 670         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly Ser Ala Ala Ala 
        675                 680                 685             


<210>  71
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein


<220>
<221>  misc_feature
<222>  (37)..(825)
<223>  scFv1 domain

<400>  71
atgggcagca gcggccatca tcatcatcat catatggagg tgcagctgtt ggagtctggg       60

ggaggcttgg tacagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc      120

ttcagtagtt atgaaatgaa ctgggtccgc caggctccag ggaaggggct ggagtgggtc      180

tcaggcatta gtggtagtgg tggtttcaca tactacgcag actccgtgaa gggccgattc      240

accatctcca gagacaattc caagaacacg ctgtatctgc aaatgaacag cctgagagcc      300

gaggacactg ccatgtatta ctgtgcgaga gaggggtacc aggatgcttt tgatatctgg      360

ggccagggta cactggtcac cgtgagcagc ggtggaggcg gttcaggcgg aggtggatcc      420

ggcggtggcg gatcgcagtc tgtgctgact cagccaccct cagcgtctgg gacccccggg      480

cagagggtca ccatctcctg cactgggagc agctccaaca tcggggcagg ttatgatgta      540

cactggtatc agcagctccc aggaacggcc cccaaactcc tcatctatag taataatcag      600

cggccctcag gggtccctga ccgattctct ggctccaagt ctggcacctc agcctccctg      660

gccatcagtg ggctccggtc cgaggatgag gctgattatt actgtgcagc atgggatgac      720

agcctgagtg gtccgccttg ggtgttcggc ggaggaacca agctgacggt cctaggtgaa      780

caaaaactca tctcagaaga ggatctgtct ggatcagcgg ctgcagggaa ttcaagccat      840

accaccccgt ggaccaaccc gggcctggcg gaaaacttta tgaacagctt tatgcagggc      900

ctgagcagca tgccgggctt taccgcgagc cagctggatg atatgagcac cattgcgcag      960

agcatggtgc agagcattca gagcctggcg gcgcagggcc gcaccagccc gaacaaactg     1020

caggcgctga acatggcgtt tgcgagcagc atggcggaaa ttgcggcgag cgaagaaggc     1080

ggcggcagcc tgagcaccaa aaccagcagc attgcgagcg cgatgagcaa cgcgtttctg     1140

cagaccaccg gcgtggtgaa ccagccgttt attaacgaaa ttacccagct ggtgagcatg     1200

tttgcgcagg cgggcatgaa cgatgtgagc gcgggcaatt cagggatcca aggttatggt     1260

cagagtagtg cttctgcttc agctgctgcg tcagctgcta gtactgtagc taattcggtg     1320

agtcgcctct catcgccttc cgcagtatct cgagtttctt cagcagtttc tagcttggtt     1380

tcaaatggtc aagtgaatat ggcagcgtta cctaatatca tttccaacat ttcttcttct     1440

gtcagtgcat ctgctcctgg tgcttctgga tgtgaggtca tagtgcaagc tctactcgaa     1500

gtcatcactg ctcttgttca aatcgttagt tcttctagtg ttggatatat taatccatct     1560

gctgtgaacc aaattactaa tgttgttgct aatgccatgg ctcaagtaat gggc           1614


<210>  72
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein


<220>
<221>  MISC_FEATURE
<222>  (13)..(275)
<223>  scFv1 domain

<400>  72

Met Gly Ser Ser Gly His His His His His His Met Glu Val Gln Leu 
1               5                   10                  15      


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            20                  25                  30          


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn Trp 
        35                  40                  45              


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser 
    50                  55                  60                  


Gly Ser Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
65                  70                  75                  80  


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
                85                  90                  95      


Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Gly 
            100                 105                 110         


Tyr Gln Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly 
145                 150                 155                 160 


Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala 
                165                 170                 175     


Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
    210                 215                 220                 


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
225                 230                 235                 240 


Ser Leu Ser Gly Pro Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                245                 250                 255     


Val Leu Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly Ser 
            260                 265                 270         


Ala Ala Ala Gly Asn Ser Ser His Thr Thr Pro Trp Thr Asn Pro Gly 
        275                 280                 285             


Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met 
    290                 295                 300                 


Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala Gln 
305                 310                 315                 320 


Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser 
                325                 330                 335     


Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala 
            340                 345                 350         


Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr 
        355                 360                 365             


Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly 
    370                 375                 380                 


Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met 
385                 390                 395                 400 


Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn Ser Gly Ile 
                405                 410                 415     


Gln Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala 
            420                 425                 430         


Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala 
        435                 440                 445             


Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln 
    450                 455                 460                 


Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser 
465                 470                 475                 480 


Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln 
                485                 490                 495     


Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser 
            500                 505                 510         


Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val 
        515                 520                 525             


Val Ala Asn Ala Met Ala Gln Val Met Gly 
    530                 535             


<210>  73
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein


<220>
<221>  misc_feature
<222>  (28)..(816)
<223>  scFv1 domain

<400>  73
atgggccatc atcatcatca tcatatggag gtgcagctgt tggagtctgg gggaggcttg       60

gtacagcctg gggggtccct gagactctcc tgtgcagcct ctggattcac cttcagtagt      120

tatgaaatga actgggtccg ccaggctcca gggaaggggc tggagtgggt ctcaggcatt      180

agtggtagtg gtggtttcac atactacgca gactccgtga agggccgatt caccatctcc      240

agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc cgaggacact      300

gccatgtatt actgtgcgag agaggggtac caggatgctt ttgatatctg gggccagggt      360

acactggtca ccgtgagcag cggtggaggc ggttcaggcg gaggtggatc cggcggtggc      420

ggatcgcagt ctgtgctgac tcagccaccc tcagcgtctg ggacccccgg gcagagggtc      480

accatctcct gcactgggag cagctccaac atcggggcag gttatgatgt acactggtat      540

cagcagctcc caggaacggc ccccaaactc ctcatctata gtaataatca gcggccctca      600

ggggtccctg accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt      660

gggctccggt ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt      720

ggtccgcctt gggtgttcgg cggaggaacc aagctgacgg tcctaggtga acaaaaactc      780

atctcagaag aggatctgtc tggatcagcg gctgcaggga attcagggat ccaaggttat      840

ggtcagagta gtgcttctgc ttcagctgct gcgtcagctg ctagtactgt agctaattcg      900

gtgagtcgcc tctcatcgcc ttccgcagta tctcgagttt cttcagcagt ttctagcttg      960

gtttcaaatg gtcaagtgaa tatggcagcg ttacctaata tcatttccaa catttcttct     1020

tctgtcagtg catctgctcc tggtgcttct ggatgtgagg tcatagtgca agctctactc     1080

gaagtcatca ctgctcttgt tcaaatcgtt agttcttcta gtgttggata tattaatcca     1140

tctgctgtga accaaattac taatgttgtt gctaatgcca tggctcaagt aatgggc        1197


<210>  74
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein


<220>
<221>  MISC_FEATURE
<222>  (10)..(272)
<223>  scFv1 domain

<400>  74

Met Gly His His His His His His Met Glu Val Gln Leu Leu Glu Ser 
1               5                   10                  15      


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            20                  25                  30          


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn Trp Val Arg Gln 
        35                  40                  45              


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Gly Ser Gly 
    50                  55                  60                  


Gly Phe Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
65                  70                  75                  80  


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                85                  90                  95      


Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Glu Gly Tyr Gln Asp 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser 
    130                 135                 140                 


Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val 
145                 150                 155                 160 


Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
                165                 170                 175     


Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly 
        195                 200                 205             


Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser 
225                 230                 235                 240 


Gly Pro Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                245                 250                 255     


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ser Gly Ser Ala Ala Ala 
            260                 265                 270         


Gly Asn Ser Gly Ile Gln Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser 
        275                 280                 285             


Ala Ala Ala Ser Ala Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu 
    290                 295                 300                 


Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu 
305                 310                 315                 320 


Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser 
                325                 330                 335     


Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys 
            340                 345                 350         


Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln 
        355                 360                 365             


Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn 
    370                 375                 380                 


Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln Val Met Gly 
385                 390                 395                 


