                         SEQUENCE LISTING

<110>  Genentech, Inc.
 
<120>  ANTI-PMEL17 ANTIBODIES AND IMMUNOCONJUGATES

<130>  GENE-32549/WO-1/ORD

<150>  US 61/641,074
<151>  2012-05-01

<150>  US 61/678,911
<151>  2012-08-02

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ser Ser Gly Tyr Ser Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Tyr Asp Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
        115                 120         


<210>  2
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Thr Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Gln Pro Gly Lys Thr Asn Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  3

Gly Tyr Ser Phe Thr Arg Tyr Thr Met Asn 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  4

Val Ile Asn Pro Tyr Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  5

Thr Asp Tyr Asp Gly Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  6

Arg Ala Thr Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  7

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Gln His Asn Glu Tyr Pro Tyr Thr 
1               5                   


<210>  9
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  9

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Tyr Asn Pro Tyr Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Ser Gly Gly Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys Thr 
        115                 120         


<210>  10
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Asp Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Thr Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  11

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala 
            100                 105                 110         


Lys Thr 
        


<210>  12
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  12

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Phe Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Val Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  13
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  13

Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
1               5                   10  


<210>  14
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  14

Val Tyr Asn Pro Tyr Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  15

Thr Asp Ser Gly Gly Tyr Ala Met Asp Cys 
1               5                   10  


<210>  16
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  16

Arg Ala Ser Lys Thr Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  17
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is selected from Arg, Lys, Gly, and Ala

<400>  17

Gly Tyr Ser Phe Thr Xaa Tyr Thr Met Asn 
1               5                   10  


<210>  18
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from Tyr, Trp, Phe, Thr, Ser, Ile, Leu, Val, Met,
       Ala, and Norleucine

<400>  18

Val Xaa Asn Pro Tyr Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from Ser, Thr, and Val

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is selected from Ser, Thr, and Val

<400>  19

Arg Ala Xaa Lys Xaa Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  20
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  20

Gly Phe Ser Leu Thr Lys Tyr Gly Val His 
1               5                   10  


<210>  21
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  21

Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  22
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  22

Thr Phe Asp Val 
1               


<210>  23
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  23

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Phe Leu Tyr 
1               5                   10                  15      


<210>  24
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  24

Arg Met Ser Asn Leu Val Ser 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  25

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  26
<211>  661
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Leu Val Leu Lys Arg Cys Leu Leu His Leu Ala Val Ile Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Gly Ala Thr Lys Val Pro Arg Asn Gln Asp Trp 
            20                  25                  30          


Leu Gly Val Ser Arg Gln Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu 
        35                  40                  45              


Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly 
    50                  55                  60                  


Gln Val Ser Leu Lys Val Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala 
65                  70                  75                  80  


Asn Ala Ser Phe Ser Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys Val 
                85                  90                  95      


Leu Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly 
            100                 105                 110         


Ser Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp 
        115                 120                 125             


Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser 
    130                 135                 140                 


Gln Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp 
145                 150                 155                 160 


Gln Val Leu Gly Gly Pro Val Ser Gly Leu Ser Ile Gly Thr Gly Arg 
                165                 170                 175     


Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg 
            180                 185                 190         


Gly Ser Arg Ser Tyr Val Pro Leu Ala His Ser Ser Ser Ala Phe Thr 
        195                 200                 205             


Ile Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Arg Ala 
    210                 215                 220                 


Leu Asp Gly Gly Asn Lys His Phe Leu Arg Asn Gln Pro Leu Thr Phe 
225                 230                 235                 240 


Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu 
                245                 250                 255     


Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr Leu Ile Ser Arg 
            260                 265                 270         


Ala Leu Val Val Thr His Thr Tyr Leu Glu Pro Gly Pro Val Thr Ala 
        275                 280                 285             


Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser Cys Gly Ser Ser 
    290                 295                 300                 


Pro Val Pro Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro 
305                 310                 315                 320 


Asn Thr Thr Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr 
                325                 330                 335     


Pro Gly Gln Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln 
            340                 345                 350         


Val Pro Thr Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr 
        355                 360                 365             


Ala Glu Ser Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val 
    370                 375                 380                 


Met Gly Thr Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met 
385                 390                 395                 400 


Thr Pro Ala Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
                405                 410                 415     


Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
            420                 425                 430         


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
        435                 440                 445             


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
    450                 455                 460                 


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
465                 470                 475                 480 


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala 
                485                 490                 495     


Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly Asp Ala Phe Glu Leu 
            500                 505                 510         


Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Glu Ile 
        515                 520                 525             


Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val 
    530                 535                 540                 


Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly 
545                 550                 555                 560 


Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Thr Asn Ser 
                565                 570                 575     


Leu Ala Val Val Ser Thr Gln Leu Ile Met Pro Gly Gln Glu Ala Gly 
            580                 585                 590         


Leu Gly Gln Val Pro Leu Ile Val Gly Ile Leu Leu Val Leu Met Ala 
        595                 600                 605             


Val Val Leu Ala Ser Leu Ile Tyr Arg Arg Arg Leu Met Lys Gln Asp 
    610                 615                 620                 


Phe Ser Val Pro Gln Leu Pro His Ser Ser Ser His Trp Leu Arg Leu 
625                 630                 635                 640 


Pro Arg Ile Phe Cys Ser Cys Pro Ile Gly Glu Asn Ser Pro Leu Leu 
                645                 650                 655     


Ser Gly Gln Gln Val 
            660     


<210>  27
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  27

Lys Val Pro Arg Asn Gln Asp Trp Leu Gly Val Ser Arg Gln Leu Arg 
1               5                   10                  15      


Thr Lys Ala Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln 
            20                  25                  30          


Arg Leu Asp Cys Trp Arg Gly Gly Gln Val Ser Leu Lys Val Ser Asn 
        35                  40                  45              


Asp Gly Pro Thr Leu Ile Gly Ala Asn Ala Ser Phe Ser Ile Ala Leu 
    50                  55                  60                  


Asn Phe Pro Gly Ser Gln Lys Val Leu Pro Asp Gly Gln Val Ile Trp 
65                  70                  75                  80  


Val Asn Asn Thr Ile Ile Asn Gly Ser Gln Val Trp Gly Gly Gln Pro 
                85                  90                  95      


Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp Gly Gly 
            100                 105                 110         


Pro Cys Pro Ser Gly Ser Trp Ser Gln Lys Arg Ser Phe Val Tyr Val 
        115                 120                 125             


Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro Val Ser 
    130                 135                 140                 


Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His Thr Met 
145                 150                 155                 160 


Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val Pro Leu 
                165                 170                 175     


Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro Phe Ser 
            180                 185                 190         


Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys His Phe 
        195                 200                 205             


Leu Arg Asn Gln Pro Leu Thr Phe Ala Leu Gln Leu His Asp Pro Ser 
    210                 215                 220                 


Gly Tyr Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe Gly Asp 
225                 230                 235                 240 


Ser Ser Gly Thr Leu Ile Ser Arg Ala Leu Val Val Thr His Thr Tyr 
                245                 250                 255     


Leu Glu Pro Gly Pro Val Thr Ala Gln Val Val Leu Gln Ala Ala Ile 
            260                 265                 270         


Pro Leu Thr Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr Asp Gly 
        275                 280                 285             


His Arg Pro Thr Ala Glu Ala Pro Asn Thr Thr Ala Gly Gln Val Pro 
    290                 295                 300                 


Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln Ala Pro Thr Ala Glu 
305                 310                 315                 320 


Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr Thr Glu Val Ile Ser 
                325                 330                 335     


Thr Ala Pro Val Gln Met Pro Thr Ala Glu Ser Thr Gly Met Thr Pro 
            340                 345                 350         


Glu Lys Val Pro Val Ser Glu Val Met Gly Thr Thr Leu Ala Glu Met 
        355                 360                 365             


Ser Thr Pro Glu Ala Thr Gly Met Thr Pro Ala Glu Val Ser Ile Val 
    370                 375                 380                 


Val Leu Ser Gly Thr Thr Ala Ala Gln Val Thr Thr Thr Glu Trp Val 
385                 390                 395                 400 


Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu Pro Glu Gly Pro Asp 
                405                 410                 415     


Ala Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro 
            420                 425                 430         


Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu Val Lys Arg Gln Val Pro 
        435                 440                 445             


Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr Leu Asp 
    450                 455                 460                 


Ile Val Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Ser 
465                 470                 475                 480 


Gly Glu Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu 
                485                 490                 495     


Pro Lys Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln Pro Pro 
            500                 505                 510         


Ala Gln Arg Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys Gln Leu 
        515                 520                 525             


Val Leu His Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys Leu Asn 
    530                 535                 540                 


Val Ser Leu Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr Gln Leu 
545                 550                 555                 560 


Ile Met Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val 
                565                 570                 575     


Gly Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr 
            580                 585                 590         


Arg Arg Arg Leu Met Lys Gln Asp Phe Ser Val Pro Gln Leu Pro His 
        595                 600                 605             


Ser Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Cys Ser Cys Pro 
    610                 615                 620                 


Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Gln Val 
625                 630                 635         


<210>  28
<211>  637
<212>  PRT
<213>  Macaca fascicularis

<400>  28

Lys Gly Pro Arg Asn Gln Asp Trp Leu Gly Val Ser Arg Gln Leu Arg 
1               5                   10                  15      


Thr Lys Ala Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln 
            20                  25                  30          


Arg Leu Asp Cys Trp Arg Gly Gly Gln Val Ser Leu Lys Val Ser Asn 
        35                  40                  45              


Asp Gly Pro Thr Leu Ile Gly Ala Asn Ala Ser Phe Ser Ile Ala Leu 
    50                  55                  60                  


Asn Phe Pro Gly Ser Gln Lys Val Leu Pro Asp Gly Gln Val Ile Trp 
65                  70                  75                  80  


Val Asn Asn Thr Ile Ile Asn Gly Ser Gln Val Trp Gly Gly Gln Pro 
                85                  90                  95      


Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp Gly Gly 
            100                 105                 110         


Pro Cys Pro Ser Gly Pro Trp Ser Gln Lys Arg Ser Phe Val Tyr Val 
        115                 120                 125             


Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro Val Ser 
    130                 135                 140                 


Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His Thr Met 
145                 150                 155                 160 


Glu Val Thr Val Tyr His Arg Arg Gly Ser Arg Ser Tyr Val Pro Leu 
                165                 170                 175     


Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro Phe Ser 
            180                 185                 190         


Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys His Phe 
        195                 200                 205             


Leu Arg Asn Gln Pro Leu Thr Phe Ala Leu Gln Leu His Asp Pro Ser 
    210                 215                 220                 


Gly Tyr Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe Gly Asp 
225                 230                 235                 240 


Ser Ser Gly Thr Leu Ile Ser Arg Ala Leu Val Val Thr His Thr Tyr 
                245                 250                 255     


Leu Glu Pro Gly Pro Val Thr Ala Gln Val Val Leu Gln Ala Ala Ile 
            260                 265                 270         


Pro Leu Thr Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr Asp Gly 
        275                 280                 285             


His Arg Pro Thr Ala Glu Ala Pro Asp Thr Thr Ala Gly Arg Gly Pro 
    290                 295                 300                 


Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln Val Pro Thr Thr Gln 
305                 310                 315                 320 


Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr Thr Glu Val Ile Ser 
                325                 330                 335     


Thr Thr Pro Val Gln Met Pro Thr Ala Glu Ser Thr Gly Thr Thr Pro 
            340                 345                 350         


Glu Lys Val Pro Val Ser Glu Val Met Gly Thr Thr Leu Ala Glu Met 
        355                 360                 365             


Ser Thr Pro Glu Ala Ile Gly Met Thr Pro Ala Glu Val Ser Ile Val 
    370                 375                 380                 


Val Pro Ser Gly Thr Thr Ala Ala Gln Val Thr Thr Thr Glu Trp Val 
385                 390                 395                 400 


Glu Thr Thr Ala Gly Glu Leu Pro Thr Pro Glu Pro Glu Gly Pro Asp 
                405                 410                 415     


Thr Ser Ser Ile Met Ser Thr Glu Ser Ile Thr Gly Ser Leu Gly Pro 
            420                 425                 430         


Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu Glu Lys Arg Gln Val Pro 
        435                 440                 445             


Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val Thr Leu Asp 
    450                 455                 460                 


Ile Val Gln Gly Ile Glu Ser Ala Glu Ile Leu Gln Val Val Pro Ser 
465                 470                 475                 480 


Ser Glu Gly Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu 
                485                 490                 495     


Pro Thr Glu Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln Pro Pro 
            500                 505                 510         


Ala Gln Gln Leu Cys Gln Pro Val Pro Pro Ser Pro Ala Cys Gln Leu 
        515                 520                 525             


Val Leu Tyr Gln Ile Leu Lys Gly Gly Leu Gly Thr Tyr Cys Leu Asn 
    530                 535                 540                 


Val Ser Leu Ala Asp Ala Asn Ser Leu Ala Val Val Ser Thr Gln Leu 
545                 550                 555                 560 


Ile Val Pro Gly Gln Glu Ala Gly Leu Gly Gln Ala Pro Leu Phe Val 
                565                 570                 575     


Gly Ile Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile Tyr 
            580                 585                 590         


Arg Arg Arg Leu Met Lys Gln Ala Phe Ser Ile Pro Gln Leu Pro His 
        595                 600                 605             


Gly Ser Ser His Trp Leu Arg Leu Pro Arg Ile Phe Arg Ser Cys Pro 
    610                 615                 620                 


Ile Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln Glu Val 
625                 630                 635         


<210>  29
<211>  418
<212>  PRT
<213>  Rattus rattus

<400>  29

Met Gly Val Gln Arg Arg Cys Phe Leu Pro Val Leu Val Leu Gly Ala 
1               5                   10                  15      


Leu Leu Ala Leu Gly Ser Ile Glu Gly Ser Arg Asn Gln Asn Trp His 
            20                  25                  30          


Gly Val Ser Arg Gln Leu Val Thr Lys Val Trp Asn Lys Gln Leu Tyr 
        35                  40                  45              


Pro Glu Trp Thr Glu Val Gln Gly Ser Asn Cys Trp Arg Gly Gly Gln 
    50                  55                  60                  


Val Ser Leu Lys Val Arg Asn Asp Gly Pro Thr Leu Val Gly Ala Asn 
65                  70                  75                  80  


Thr Ser Phe Ser Ile Ala Leu His Phe Pro Gly Ser Gln Lys Val Leu 
                85                  90                  95      


Pro Asp Gly Gln Val Ile Trp Val Asn Asn Thr Ile Ile Asn Gly Ser 
            100                 105                 110         


Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Arg Glu Pro Asp Asp Ala 
        115                 120                 125             


Cys Ile Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Pro Lys Pro Pro 
    130                 135                 140                 


Arg Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln 
145                 150                 155                 160 


Val Leu Gly Gly Pro Glu Ser Lys Leu Ser Ile Pro Thr Gly His Ala 
                165                 170                 175     


Arg Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg Gly 
            180                 185                 190         


Ser Gln Ser Tyr Val Pro Leu Ala His Ser Ser Ser Thr Phe Thr Ile 
        195                 200                 205             


Thr Gly Ser Val Ser Arg Leu Leu Asp Asp Thr Asp Thr Ile Met Leu 
    210                 215                 220                 


Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser 
225                 230                 235                 240 


Phe Ser Leu Thr Leu Asp Ile Val Gln Gly Ile Glu Ser Ala Glu Ile 
                245                 250                 255     


Leu Gln Ala Val Pro Ser Ser Glu Gly Asp Ala Phe Glu Leu Thr Val 
            260                 265                 270         


Ser Cys Arg Gly Gly Leu Pro Lys Glu Ala Cys Met Asp Ile Ser Ser 
        275                 280                 285             


Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Pro Val Pro Pro 
    290                 295                 300                 


Ser Pro Asp Cys Gln Leu Val Leu His Gln Ile Leu Lys Gly Gly Leu 
305                 310                 315                 320 


Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Ala Asn Ser Leu Ala 
                325                 330                 335     


Val Ala Ser Thr Gln Leu Val Val Pro Gly Gln Glu Gly Ser Leu Gly 
            340                 345                 350         


Gln Ala Pro Leu Leu Val Gly Val Leu Leu Val Leu Val Ala Val Val 
        355                 360                 365             


Leu Ala Ser Leu Ile Tyr Arg His Arg Leu Lys Lys Gln Asp Ser Val 
    370                 375                 380                 


Ser Gln Thr Pro His Gly Ser Thr His Trp Leu Arg Leu Pro Pro Val 
385                 390                 395                 400 


Phe Cys Ala Arg Arg Leu Gly Glu Ser Ser Pro Leu Leu Ser Gly Gln 
                405                 410                 415     


Gln Val 
        


<210>  30
<211>  393
<212>  PRT
<213>  Rattus rattus

<400>  30

Ser Arg Asn Gln Asn Trp His Gly Val Ser Arg Gln Leu Val Thr Lys 
1               5                   10                  15      


Val Trp Asn Lys Gln Leu Tyr Pro Glu Trp Thr Glu Val Gln Gly Ser 
            20                  25                  30          


Asn Cys Trp Arg Gly Gly Gln Val Ser Leu Lys Val Arg Asn Asp Gly 
        35                  40                  45              


Pro Thr Leu Val Gly Ala Asn Thr Ser Phe Ser Ile Ala Leu His Phe 
    50                  55                  60                  


Pro Gly Ser Gln Lys Val Leu Pro Asp Gly Gln Val Ile Trp Val Asn 
65                  70                  75                  80  


Asn Thr Ile Ile Asn Gly Ser Gln Val Trp Gly Gly Gln Pro Val Tyr 
                85                  90                  95      


Pro Arg Glu Pro Asp Asp Ala Cys Ile Phe Pro Asp Gly Gly Pro Cys 
            100                 105                 110         


Pro Ser Gly Pro Lys Pro Pro Arg Arg Ser Phe Val Tyr Val Trp Lys 
        115                 120                 125             


Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro Glu Ser Lys Leu 
    130                 135                 140                 


Ser Ile Pro Thr Gly His Ala Arg Leu Gly Thr His Thr Met Glu Val 
145                 150                 155                 160 


Thr Val Tyr His Arg Arg Gly Ser Gln Ser Tyr Val Pro Leu Ala His 
                165                 170                 175     


Ser Ser Ser Thr Phe Thr Ile Thr Gly Ser Val Ser Arg Leu Leu Asp 
            180                 185                 190         


Asp Thr Asp Thr Ile Met Leu Val Lys Arg Gln Val Pro Leu Asp Cys 
        195                 200                 205             


Val Leu Tyr Arg Tyr Gly Ser Phe Ser Leu Thr Leu Asp Ile Val Gln 
    210                 215                 220                 


Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Ser Ser Glu Gly 
225                 230                 235                 240 


Asp Ala Phe Glu Leu Thr Val Ser Cys Arg Gly Gly Leu Pro Lys Glu 
                245                 250                 255     


Ala Cys Met Asp Ile Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg 
            260                 265                 270         


Leu Cys Gln Pro Val Pro Pro Ser Pro Asp Cys Gln Leu Val Leu His 
        275                 280                 285             


Gln Ile Leu Lys Gly Gly Leu Gly Thr Tyr Cys Leu Asn Val Ser Leu 
    290                 295                 300                 


Ala Asp Ala Asn Ser Leu Ala Val Ala Ser Thr Gln Leu Val Val Pro 
305                 310                 315                 320 


Gly Gln Glu Gly Ser Leu Gly Gln Ala Pro Leu Leu Val Gly Val Leu 
                325                 330                 335     


Leu Val Leu Val Ala Val Val Leu Ala Ser Leu Ile Tyr Arg His Arg 
            340                 345                 350         


Leu Lys Lys Gln Asp Ser Val Ser Gln Thr Pro His Gly Ser Thr His 
        355                 360                 365             


Trp Leu Arg Leu Pro Pro Val Phe Cys Ala Arg Arg Leu Gly Glu Ser 
    370                 375                 380                 


Ser Pro Leu Leu Ser Gly Gln Gln Val 
385                 390             


<210>  31
<211>  626
<212>  PRT
<213>  Mus musculus

<400>  31

Met Gly Val Gln Arg Arg Ser Phe Leu Pro Val Leu Val Leu Ser Ala 
1               5                   10                  15      


Leu Leu Ala Val Gly Ala Leu Glu Gly Ser Arg Asn Gln Asp Trp Leu 
            20                  25                  30          


Gly Val Pro Arg Gln Leu Val Thr Lys Thr Trp Asn Arg Gln Leu Tyr 
        35                  40                  45              


Pro Glu Trp Thr Glu Val Gln Gly Ser Asn Cys Trp Arg Gly Gly Gln 
    50                  55                  60                  


Val Ser Leu Arg Val Ile Asn Asp Gly Pro Thr Leu Val Gly Ala Asn 
65                  70                  75                  80  


Ala Ser Phe Ser Ile Ala Leu His Phe Pro Gly Ser Gln Lys Val Leu 
                85                  90                  95      


Pro Asp Gly Gln Val Ile Trp Ala Asn Asn Thr Ile Ile Asn Gly Ser 
            100                 105                 110         


Gln Val Trp Gly Gly Gln Pro Val Tyr Pro Gln Glu Pro Asp Asp Ala 
        115                 120                 125             


Cys Val Phe Pro Asp Gly Gly Pro Cys Pro Ser Gly Pro Lys Pro Pro 
    130                 135                 140                 


Lys Arg Ser Phe Val Tyr Val Trp Lys Thr Trp Gly Lys Tyr Trp Gln 
145                 150                 155                 160 


Val Leu Gly Gly Pro Val Ser Arg Leu Ser Ile Ala Thr Gly His Ala 
                165                 170                 175     


Lys Leu Gly Thr His Thr Met Glu Val Thr Val Tyr His Arg Arg Gly 
            180                 185                 190         


Ser Gln Ser Tyr Val Pro Leu Ala His Ala Ser Ser Thr Phe Thr Ile 
        195                 200                 205             


Thr Asp Gln Val Pro Phe Ser Val Ser Val Ser Gln Leu Gln Ala Leu 
    210                 215                 220                 


Asp Gly Glu Thr Lys His Phe Leu Arg Asn His Pro Leu Ile Phe Ala 
225                 230                 235                 240 


Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala Glu Ala Asp Leu Ser 
                245                 250                 255     


Tyr Thr Trp Asp Phe Gly Asp Gly Thr Gly Thr Leu Ile Ser Arg Ala 
            260                 265                 270         


Leu Asp Val Thr His Thr Tyr Leu Glu Ser Gly Ser Val Thr Ala Gln 
        275                 280                 285             


Val Val Leu Gln Ala Ala Ile Pro Leu Val Ser Cys Gly Ser Ser Pro 
    290                 295                 300                 


Val Pro Gly Thr Thr Asp Gly Tyr Met Pro Thr Ala Glu Ala Pro Gly 
305                 310                 315                 320 


Thr Thr Ser Arg Gln Gly Thr Thr Thr Lys Val Val Gly Thr Thr Pro 
                325                 330                 335     


Gly Gln Met Pro Thr Thr Gln Pro Ser Gly Thr Thr Val Val Gln Met 
            340                 345                 350         


Pro Thr Thr Glu Val Thr Ala Thr Thr Ser Glu Gln Met Leu Thr Ser 
        355                 360                 365             


Ala Val Ile Asp Thr Thr Leu Ala Glu Val Ser Thr Thr Glu Gly Thr 
    370                 375                 380                 


Gly Thr Thr Pro Thr Arg Pro Ser Gly Thr Thr Val Ala Gln Ala Thr 
385                 390                 395                 400 


Thr Thr Glu Gly Pro Asp Ala Ser Pro Leu Leu Pro Thr Gln Ser Ser 
                405                 410                 415     


Thr Gly Ser Ile Ser Pro Leu Leu Asp Asp Thr Asp Thr Ile Met Leu 
            420                 425                 430         


Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr Gly Ser 
        435                 440                 445             


Phe Ser Leu Ala Leu Asp Ile Val Gln Gly Ile Glu Ser Ala Glu Ile 
    450                 455                 460                 


Leu Gln Ala Val Pro Phe Ser Glu Gly Asp Ala Phe Glu Leu Thr Val 
465                 470                 475                 480 


Ser Cys Gln Gly Gly Leu Pro Lys Glu Ala Cys Met Asp Ile Ser Ser 
                485                 490                 495     


Pro Gly Cys Gln Pro Pro Ala Gln Arg Leu Cys Gln Ser Val Pro Pro 
            500                 505                 510         


Ser Pro Asp Cys Gln Leu Val Leu His Gln Val Leu Lys Gly Gly Ser 
        515                 520                 525             


Gly Thr Tyr Cys Leu Asn Val Ser Leu Ala Asp Ala Asn Ser Leu Ala 
    530                 535                 540                 


Val Ala Ser Thr Gln Leu Val Val Pro Gly Gln Asp Gly Gly Leu Gly 
545                 550                 555                 560 


Gln Ala Pro Leu Leu Val Gly Ile Leu Leu Val Leu Val Ala Val Val 
                565                 570                 575     


Leu Ala Ser Leu Ile His Arg His Arg Leu Lys Lys Gln Gly Ser Val 
            580                 585                 590         


Ser Gln Met Pro His Gly Ser Thr His Trp Leu Arg Leu Pro Pro Val 
        595                 600                 605             


Phe Arg Ala Arg Gly Leu Gly Glu Asn Ser Pro Leu Leu Ser Gly Gln 
    610                 615                 620                 


Gln Val 
625     


<210>  32
<211>  601
<212>  PRT
<213>  Mus musculus

<400>  32

Ser Arg Asn Gln Asp Trp Leu Gly Val Pro Arg Gln Leu Val Thr Lys 
1               5                   10                  15      


Thr Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Val Gln Gly Ser 
            20                  25                  30          


Asn Cys Trp Arg Gly Gly Gln Val Ser Leu Arg Val Ile Asn Asp Gly 
        35                  40                  45              


Pro Thr Leu Val Gly Ala Asn Ala Ser Phe Ser Ile Ala Leu His Phe 
    50                  55                  60                  


Pro Gly Ser Gln Lys Val Leu Pro Asp Gly Gln Val Ile Trp Ala Asn 
65                  70                  75                  80  


Asn Thr Ile Ile Asn Gly Ser Gln Val Trp Gly Gly Gln Pro Val Tyr 
                85                  90                  95      


Pro Gln Glu Pro Asp Asp Ala Cys Val Phe Pro Asp Gly Gly Pro Cys 
            100                 105                 110         


Pro Ser Gly Pro Lys Pro Pro Lys Arg Ser Phe Val Tyr Val Trp Lys 
        115                 120                 125             


Thr Trp Gly Lys Tyr Trp Gln Val Leu Gly Gly Pro Val Ser Arg Leu 
    130                 135                 140                 


Ser Ile Ala Thr Gly His Ala Lys Leu Gly Thr His Thr Met Glu Val 
145                 150                 155                 160 


Thr Val Tyr His Arg Arg Gly Ser Gln Ser Tyr Val Pro Leu Ala His 
                165                 170                 175     


Ala Ser Ser Thr Phe Thr Ile Thr Asp Gln Val Pro Phe Ser Val Ser 
            180                 185                 190         


Val Ser Gln Leu Gln Ala Leu Asp Gly Glu Thr Lys His Phe Leu Arg 
        195                 200                 205             


Asn His Pro Leu Ile Phe Ala Leu Gln Leu His Asp Pro Ser Gly Tyr 
    210                 215                 220                 


Leu Ala Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe Gly Asp Gly Thr 
225                 230                 235                 240 


Gly Thr Leu Ile Ser Arg Ala Leu Asp Val Thr His Thr Tyr Leu Glu 
                245                 250                 255     


Ser Gly Ser Val Thr Ala Gln Val Val Leu Gln Ala Ala Ile Pro Leu 
            260                 265                 270         


Val Ser Cys Gly Ser Ser Pro Val Pro Gly Thr Thr Asp Gly Tyr Met 
        275                 280                 285             


Pro Thr Ala Glu Ala Pro Gly Thr Thr Ser Arg Gln Gly Thr Thr Thr 
    290                 295                 300                 


Lys Val Val Gly Thr Thr Pro Gly Gln Met Pro Thr Thr Gln Pro Ser 
305                 310                 315                 320 


Gly Thr Thr Val Val Gln Met Pro Thr Thr Glu Val Thr Ala Thr Thr 
                325                 330                 335     


Ser Glu Gln Met Leu Thr Ser Ala Val Ile Asp Thr Thr Leu Ala Glu 
            340                 345                 350         


Val Ser Thr Thr Glu Gly Thr Gly Thr Thr Pro Thr Arg Pro Ser Gly 
        355                 360                 365             


Thr Thr Val Ala Gln Ala Thr Thr Thr Glu Gly Pro Asp Ala Ser Pro 
    370                 375                 380                 


Leu Leu Pro Thr Gln Ser Ser Thr Gly Ser Ile Ser Pro Leu Leu Asp 
385                 390                 395                 400 


Asp Thr Asp Thr Ile Met Leu Val Lys Arg Gln Val Pro Leu Asp Cys 
                405                 410                 415     


Val Leu Tyr Arg Tyr Gly Ser Phe Ser Leu Ala Leu Asp Ile Val Gln 
            420                 425                 430         


Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Phe Ser Glu Gly 
        435                 440                 445             


Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu 
    450                 455                 460                 


Ala Cys Met Asp Ile Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg 
465                 470                 475                 480 


Leu Cys Gln Ser Val Pro Pro Ser Pro Asp Cys Gln Leu Val Leu His 
                485                 490                 495     


Gln Val Leu Lys Gly Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu 
            500                 505                 510         


Ala Asp Ala Asn Ser Leu Ala Val Ala Ser Thr Gln Leu Val Val Pro 
        515                 520                 525             


Gly Gln Asp Gly Gly Leu Gly Gln Ala Pro Leu Leu Val Gly Ile Leu 
    530                 535                 540                 


Leu Val Leu Val Ala Val Val Leu Ala Ser Leu Ile His Arg His Arg 
545                 550                 555                 560 


Leu Lys Lys Gln Gly Ser Val Ser Gln Met Pro His Gly Ser Thr His 
                565                 570                 575     


Trp Leu Arg Leu Pro Pro Val Phe Arg Ala Arg Gly Leu Gly Glu Asn 
            580                 585                 590         


Ser Pro Leu Leu Ser Gly Gln Gln Val 
        595                 600     


<210>  33
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  33

Gly Tyr Thr Phe Thr Ser Tyr Trp Met Gln 
1               5                   10  


<210>  34
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  34

Thr Ile Tyr Pro Gly Asp Gly Asp Thr Ser Tyr Ala Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  35

Trp Gly Tyr Ala Tyr Asp Ile Asp Asn 
1               5                   


<210>  36
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  36

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  37
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  37

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  38

Trp Gln Gly Thr His Phe Pro Tyr Thr 
1               5                   


<210>  39
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  40
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Thr Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Ala Tyr Asp Ile Asp Asn Trp Gly 
            100                 105                 


<210>  41
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  41

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Thr Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  42
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  42

Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Tyr Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Ala Tyr Asp Ile Asp Asn Trp Gly 
            100                 105                 


<210>  43
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  43

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Thr Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  44
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  44

Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Tyr Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Ala Tyr Asp Ile Asp Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  45
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  46
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Ser Thr Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Ala Tyr Asp Ile Asp Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  47
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  47

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Thr Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Gln Pro Gly Lys Thr Asn Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  48
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  48

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ser Ser Gly Tyr Ser Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Tyr Asp Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  49
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  49

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Tyr Asn Pro Tyr Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Ser Gly Gly Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  50

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ser Ser Gly Tyr Ser Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asn Gly Gly Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Tyr Asp Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  51
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  51

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110     


